Catalase Cancer Research Results

Catalase, Catalase: Click to Expand ⟱
Source:
Type:
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Caspase-1 may have both tumorigenic or antitumorigenic effects on cancer development and progression, but it depends on the type of inflammasome, methodology, and cancer.
Catalase is an enzyme found in nearly all living cells exposed to oxygen. Its primary role is to protect cells from oxidative damage by catalyzing the conversion of hydrogen peroxide (H₂O₂), a potentially damaging byproduct of metabolism, into water (H₂O) and oxygen (O₂). This detoxification process is crucial because excess H₂O₂ can lead to the formation of reactive oxygen species (ROS) that damage proteins, lipids, and DNA.

Catalase and Cancer
Oxidative Stress and Cancer:
Cancer cells often experience increased levels of oxidative stress due to rapid proliferation and metabolic changes. This stress can lead to DNA damage, promoting tumorigenesis.
Catalase helps mitigate oxidative stress, and its expression can influence the survival and proliferation of cancer cells.
Expression Levels in Different Cancers:
Overexpression: In some cancers, such as breast cancer and certain types of leukemia, catalase may be overexpressed. This overexpression can help cancer cells survive in oxidative environments, potentially leading to more aggressive tumor behavior.
Downregulation: Conversely, in other cancers, such as colorectal cancer, reduced catalase expression has been observed. This downregulation can lead to increased oxidative stress, contributing to tumor progression and metastasis.
Prognostic Implications:
Survival Rates: Studies have shown that high levels of catalase expression can be associated with poor prognosis in certain cancers, as it may enable cancer cells to resist apoptosis (programmed cell death) induced by oxidative stress.

Some types of cancer cells have been reported to exhibit lower catalase activity, possibly increasing their vulnerability to oxidative damage under certain conditions. This vulnerability has even been exploited in some therapeutic strategies (for example, approaches that generate excess H₂O₂ or other ROS specifically targeting cancer cells have been researched).
Scientific Papers found: Click to Expand⟱
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1/SREBF1↓, *FASN↓, *ACC↓,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2/PTGS2↓, *LDL↓, *Synergy↑, *ER Stress↓, *BioAv↑, *Synergy↑, *MMPs↓, *COX2/PTGS2↓, *RAGE↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
1709- Lyco,    Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
- in-vitro, Nor, JB6
*antiOx↑, *NRF2↑, *GSH/GSSG↓, *Catalase↝, *GR↝, *SOD↝, *GPx↝, *GSH↑, *Keap1↓, *p62↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
8421- Lyco,    Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *AntiMyl↑, *ROS↓, *MMP↑, *NGF↑, *BDNF↑, *VEGF↑, *Aβ42↓, *PI3K↑, *Akt↑, *NRF2↑, *lipid-P↓, *GSH↑, *Catalase↑, *SOD↑, *cognitive↑, *Learn↑, *memory↑, *APP↓, *BACE/β-secretase↓, *ADAM10↑, *NF-kB↓, *AChE↓, *MAOA↓, *BioAv↝,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
4801- Lyco,    Lycopene in the Prevention of Cardiovascular Diseases
- Review, CardioV, NA
*BioAv↝, *cardioP↑, *BioAv↑, *BioAv↑, *antiOx↑, *ROS↓, *ARE↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *COX2/PTGS2↓, *Inflam↓, *IL1β↓, *IL6↓, *IL8↑, *TNF-α↓, *NF-kB↓, *BP↓,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↑, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27/CDKN1B↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,
8503- MAG,    Magnolol mitigates neuroinflammation via NF-κB/IL-6/IL-1β pathways in AlCl₃-induced Alzheimer's disease: insights from in-vivo and in-silico investigations
- in-vivo, AD, NA
*Dose↝, *LDH↓, *NO↓, *cognitive↑, *GSH↑, *Catalase↑, *SOD↑, *neuroP↑, *NF-kB↓, *IL6↓, *IL1β↓, *neuroP↑, *ROS↓, *Inflam↓,
4529- MAG,    Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review
- Review, Diabetic, NA
*AntiDiabetic↑, *glucose↓, *SOD↑, *Catalase↑, *ROS↓, *MDA↓, *GPx↑, *CYP2E1↓, *AGEs↓, *IL10↑, *neuroP↑, *GutMicro↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8553- Matr,    Research progress on the pharmacological effects of matrine
- Review, Nor, NA
*AntiCan↑, *antiAll↑, *Stroke↓, TumCI↓, TumCMig↓, TumCP↓, TumCCA↑, *AGEs↓, *Inflam↓, *antiOx↑, *neuroP↑, *Apoptosis↓, *IBI↑, *GutMicro↑, EGFR↓, *HSP60/HSPD1↓, *antiOx↑, *GSH↑, *Catalase↑, *AChE↓, *BChE↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *cognitive↑, *ROS↓, *toxicity↑,
8924- MBS,    Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits
- Review, Var, NA
*hepatoP↑, *AntiCan↑, *Ingr↝, *NO↓, *TNF-α↓, *IL6↓, *IL1β↓, *TG/TAG↓, *BG↓, *LDL↓, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *mt-ROS↓, *Ingr?, Risk↓,
8723- MeJa,    Methyl Jasmonate Reduces Inflammation and Oxidative Stress in the Brain of Arthritic Rats
- in-vivo, Arthritis, NA
*Dose?, *lipid-P↓, *ROS↓, *Catalase↑, *SOD↑, *GSH↑, *IDH1↑, *NADPH↑, *HK2↑,
1204- MET,    Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
MDA↑, ROS↑, Iron↑, GSH↓, T-SOD↓, Catalase↓, GPx4↓, xCT/SLC7A11↓, NRF2↓, HO-1↓,
5241- MF,    A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment
- Review, Var, NA
other↑, BloodF↑, Glycolysis↓, ATP↓, VEGF↓, ROS↑, P-gp/ABCB1↓, Apoptosis↑, selectivity↑, Ca+2↑, Catalase↑,
2253- MF,    Low-frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury
- in-vivo, Nor, NA
*Inflam↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *iNOS↓, *ROS↓, Catalase↑, *SOD↑, *HSP70/HSPA5↑, *neuroP↑, *motorD↑, *antiOx↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, RadioS↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
4092- MF,    Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncology
- Review, Var, NA
Apoptosis↑, selectivity↑, ROS↑, Catalase↓, TumVol↓, angioG↓, Ca+2↝, eff↝, angioG↓, Imm↝, TNF-α↑, Casp8↑,
4147- MF,    PEMFs Restore Mitochondrial and CREB/BDNF Signaling in Oxidatively Stressed PC12 Cells Targeting Neurodegeneration
- in-vitro, AD, PC12
*ROS↓, *Catalase↑, *MMP↑, *Casp3↓, *p‑ERK↓, *cAMP↑, *p‑CREB↑, *BDNF↑, *neuroP↑,
4102- MF,    Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients
- Human, Stroke, NA
*Catalase↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *Dose↝,
4111- MF,    Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell
- Review, Arthritis, NA
*Inflam↓, *Cartilage↑, *Pain↓, *QoL↑, *Dose↝, *VEGF↑, *NO↑, *TGF-β↑, *MMP9↓, *PGE2↑, *GPx3↑, *SOD2↑, *Catalase↑, *GSR↑, *Ca+2↑,
4116- MF,    Low‑frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury
- in-vivo, Nor, NA
*Inflam↓, *TNF-α↓, *IL1β↓, *iNOS↓, *ROS↓, *Catalase↑, *SOD↑, HSP70/HSPA5↑,
3498- MF,    Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues
- in-vitro, GC, NA
*SOD↑, *MDA↓, SOD↓, GPx↓, MDA↑, Catalase↑,
3484- MF,    Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O2 − and H2O2
- in-vitro, Nor, NA
*GPx↑, *SOD2↑, *Catalase↑, *GSR↑, *ROS↓,
3567- MFrot,  MF,    The Effect of Extremely Low-Frequency Magnetic Field on Stroke Patients: A Systematic Review
- Review, Stroke, NA
*Stroke↓, *ROS↓, *Inflam↓, *cognitive↑, *Catalase↑, *SOD↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *IL1β↑, *neuroP↑, *toxicity∅,
209- MFrot,  MF,    The effect of a rotating magnetic field on the antioxidant system in healthy volunteers - preliminary study
- Human, NA, NA
*SOD↑, *Catalase↑, *ROMO1↑, *MDA↓, *TAC↑, *ROS↓,
8455- Mg,    Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis
- in-vivo, AD, NA
*Learn↑, *memory↑, *cognitive↑, *ROS↓, *Inflam↓, *GutMicro↑, *IBI↑, *MDA↓, *SOD↑, *Catalase↑, *TNF-α↓, *IL1β↓, *IL10↑,
8672- MLT,    Glioblastoma and Melatonin’s Effects: A Narrative Review
- Review, GBM, NA
selectivity↑, *ROS↓, *DNAdam↓, *SOD↑, *Catalase↑, *GPx↑, *Inflam↓, *EGF↓, *HIF-1↓, Pyruv↓, Glycolysis↓, ROS↑, TumCG↓, IL1β↓, ICAM-1↓, VCAM-1↓, NRF2↓, RadioS↑, OS↑, NAD↓, LDHA↓, MCT4↓, pH↝, ChemoSen↑, Synergy↑, TRPV1↓, Pain↓, Synergy↑, Dose↑,
8670- MLT,    Antitumor Effects of Melatonin in Luminal and Triple-Negative Breast Cancer Cells: Metabolic Reprogramming, Redox Regulation, and Cellular Dynamics
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, TumCMig↓, TumCI↓, GAPDH↓, Hif1a↓, citrate↓, ROS↑, lipid-P↑, LDH↓, G6PD↓, MDA?, Catalase↓, GPx↑, GSH↑, *ROS↓,
8663- MLT,    Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
- vitro+vivo, RCC, 786-O
TumCG↓, ROS↑, TAC↓, TCA↑, Glycolysis↓, OCR↑, ATP↑, MMP↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, VEGFR1↓, eff↓, Synergy↑, Warburg↓, TumCP↓, SOD↓, GSH↓, Catalase↓, GPx↑, Warburg↓, OXPHOS↑, Hif1a↓, VEGF↓, Ki-67↓, Akt↓, mTOR↓,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
6419- MLT,    The potential influence of melatonin on mitochondrial quality control: a review
- Review, Nor, NA
*mt-ACC⇅, *PKM1↑, *PKM2↑, *Glycolysis↝, *PDKs↑, *FAO↑, *ETC↑, *OXPHOS↑, *ATP↑, Glycolysis↓, OXPHOS↑, *Ca+2↓, *ROS↓, *antiOx↑, *SOD2↑, *GPx↑, *Catalase↑, *MFN1↑, *MFN2↑, *OPA1↑, *YAP/TEAD↑, *Hippo↑, *SIRT1↑, *PGC-1α↑, *DRP1/DNM1L↓,
1779- MLT,    Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review
- Review, BC, NA
QoL↑, OS↑, Dose∅, antiOx↑, ROS↑, SOD↑, Catalase↑, GPx↑, Risk↓, NK cell↑, IL1β↓, IL6↓, TNF-α↓, radioP↑, chemoP↑, TumVol↓, TumMeta↓, angioG↓, ChemoSen↑, eff↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
3844- MO,    Review of the Safety and Efficacy of Moringa oleifera
- Review, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
3840- MO,    Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia
- in-vivo, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *cognitive↑, *ROS↓, *Ach↑,
3839- MO,    Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation
- in-vitro, AD, NA
*eff↑, *ROS↓, *lipid-P↓, *GSH↑, *antiOx↑, *Ca+2↓, *MMP↑, *neuroP↑, *BBB↑, *Catalase↑, *SOD↑, GPx↑,
3838- MO,    Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves
- in-vitro, AD, PC12 - Review, Stroke, NA
*Inflam↓, *neuroP↑, *antiOx↑, *ROS↓, *memory↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *eff↑,
8613- MO,    Unraveling the Effects of Melissa officinalis L. on Cognition and Sleep Quality: A Narrative Review
- Review, AD, NA
*Sleep↑, *Mood↑, *Synergy↑, *QoL↑, *cognitive↑, *ROS↓, *NRF2↑, *HO-1↑, *NF-kB↓, *TNF-α↓, *COX2/PTGS2↓, *MDA↓, *Catalase↑, *SOD↑, *BDNF↑, *Dose↝,
8915- MO,    Therapeutic Potential of Moringa oleifera in Alzheimer’s Disease: A Review of Neuroprotective Mechanisms
- Review, AD, NA
*Ingr↝, *antiOx↑, *Inflam↓, *NRF2↑, *ARE↑, *AChE↓, *Aβ42↓, *cognitive↑, *BACE/β-secretase↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *Learn↑, *memory↑, *ATP↑, *SOD↑, *Catalase↑, *p‑tau↓,
8908- MO,    Water Extracts of Moringa oleifera Leaves Alter Oxidative Stress-Induced Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells
- in-vitro, AD, SH-SY5Y
*antiOx↑, *ROS↓, *GPx↑, *Catalase↑, *SOD↑, *Bcl-2↓, *BAX↓, *Casp3↓, *BDNF↑, *p‑Akt↑, *p‑CREB↑, *neuroP↑,
8875- MOR,    Neuroprotective Effect of Morin Against Chemical-Induced Neurotoxicities and Neurodegenerative Disease Models
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *chemoP↑, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *ROS↓, *MDA↓, *NO↓, *TLR4↓, *NF-kB↓, *ERK↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓,
8872- MOR,    Morin attenuates memory deficits in a rat model of Alzheimer's disease by ameliorating oxidative stress and neuroinflammation
- in-vivo, AD, NA
*Dose↝, *MDA↓, *NO↓, *GSH↑, *Catalase↑, *TNF-α↓, *IL1β↓, *IL6↓, *NF-kB↓, *BDNF↑, *antiOx↑, *NeuroI↓, *memory↑,
8863- MOR,    Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect
- in-vitro, Colon, SW48
TumCP↓, Apoptosis↑, ROS↑, MMP↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, ATP↓, GlucoseCon↓, GLUT1↓, Warburg↓, Dose↝, Catalase↓, GSH↓, ADP:ATP↑, AMP↑,
8879- MOR,  doxoR,    Synergistic Effects of Morin and Doxorubicin Overcome Chemoresistance in Ovarian Cancer: Preclinical Insights From in vitro and in vivo Models
- vitro+vivo, Ovarian, OVCAR-3 - NA, Melanoma, A2780S
Dose↝, ChemoSen↑, cycA1/CCNA1↓, cycD1/CCND1↓, TumVol↓, Apoptosis↑, TumCCA↑, ROS↝, chemoP↑, TumAuto↑, ROS↓, SOD↑, Catalase↑, GSH↑, MDA↓, cardioP↑, mTOR↓, PI3K↓, Akt↓, Bcl-2↓, Casp3↑, Casp9↑, LC3A↑, ATG5↑, Beclin-1/ATG6↑,

Showing Research Papers: 201 to 250 of 346
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 346

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 11,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 44,   Catalase↑, 34,   Catalase↝, 1,   Catalase∅, 2,   GCLM↑, 2,   GPx↓, 8,   GPx↑, 19,   GPx1⇅, 1,   GPx1∅, 1,   GPx4↓, 4,   GSH↓, 30,   GSH↑, 15,   GSH/GSSG↓, 2,   GSR↓, 1,   GSR↑, 4,   GSS↑, 1,   GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 4,   GSTs∅, 1,   H2O2↓, 3,   H2O2↑, 2,   HO-1↓, 6,   HO-1↑, 12,   Iron↑, 1,   i-Iron↑, 1,   lipid-P↓, 5,   lipid-P↑, 9,   MDA?, 1,   MDA↓, 8,   MDA↑, 12,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 3,   NRF2↓, 12,   NRF2↑, 18,   NRF2↝, 1,   Prx↓, 2,   PrxII↓, 1,   ROS↓, 27,   ROS↑, 97,   ROS⇅, 2,   ROS↝, 1,   i-ROS↑, 1,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 27,   SOD↑, 25,   SOD∅, 1,   SOD1↓, 2,   SOD1↑, 3,   SOD2↓, 7,   SOD2↑, 2,   T-SOD↓, 1,   TAC↓, 3,   TBARS↑, 1,   Thiols↓, 1,   TOS↑, 1,   Trx↓, 2,   Trx1↓, 1,   Trx1↑, 1,   TrxR↓, 1,   uricA↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 1,   CDC25↓, 4,   compI↓, 1,   compIII↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 7,   OCR↑, 2,   OXPHOS↑, 4,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↓, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 2,   ALAT↓, 3,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 5,   ATP↓, 7,   ATP↑, 2,   mt-ATP↓, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 1,   FAO↑, 1,   FASN↓, 3,   G6PD↓, 1,   GAPDH↓, 1,   GLO-I↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 12,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 4,   HK2↓, 4,   lactateProd↓, 4,   LDHA↓, 4,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 2,   NADPH↑, 4,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PKM2↓, 3,   Pyruv↓, 1,   SCD1↓, 1,   SIRT1↓, 4,   SIRT1↑, 4,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 7,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 5,   Apoptosis↓, 5,   Apoptosis↑, 74,   ASC↓, 1,   BAD↓, 1,   BAD↑, 4,   Bak↓, 1,   Bak↑, 2,   BAX↓, 4,   BAX↑, 47,   Bax:Bcl2↑, 6,   Bcl-2↓, 48,   Bcl-2↑, 3,   Bcl-xL↓, 9,   Bcl-xL↑, 1,   BID↑, 2,   BIM↑, 1,   BNIP3↑, 1,   Casp↑, 10,   Casp↝, 1,   Casp1↓, 1,   Casp3↓, 2,   Casp3↑, 53,   cl‑Casp3↑, 7,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 17,   cl‑Casp8↑, 1,   Casp9↑, 37,   cl‑Casp9↑, 6,   proCasp9↓, 1,   cFLIP↓, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 26,   mt-Cyt‑c↓, 1,   Diablo↑, 1,   DR5↑, 6,   FADD↑, 1,   Fas↑, 10,   FasL↑, 2,   Ferroptosis↑, 1,   GSDMD↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 4,   iNOS↑, 1,   Mcl-1↓, 1,   MDM2↓, 3,   p‑MDM2↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 7,   p‑p38↑, 3,   pS2/TFF1↑, 1,   PUMA↑, 3,   survivin↓, 9,   TumCD↑, 9,   XIAP↓, 9,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 44,   Akt↑, 5,   p‑Akt↓, 12,   AMPKα↑, 1,   BRAF↑, 1,   BRAF↝, 1,   CK2↓, 2,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 9,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 16,   ERK↑, 1,   p‑ERK↓, 4,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   IGF-1R↓, 3,   IKKα↓, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 2,   JNK↓, 2,   JNK↑, 9,   p‑JNK↓, 1,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 9,   MAPK↑, 11,   MAPK↝, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   p‑MEK↓, 2,   MKK4↓, 1,   mTOR↓, 25,   mTOR↝, 1,   p‑mTOR↓, 4,   P70S6K↓, 3,   p‑P70S6K↓, 1,   PI3K↓, 33,   PI3K↑, 3,   p‑PI3K↓, 2,   p‑PI3K↑, 1,   PI3K/Akt↓, 2,   PI3K/Akt↝, 1,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 5,   PTEN↝, 1,   Raf↓, 2,   RAS↓, 5,   RAS↑, 1,   Sp1/3/4↓, 4,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 24,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3,   cJun↓, 1,   cMyc↓, 8,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 2,   EZH2↓, 2,   FOXM1↓, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 3,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HATs↓, 1,   HDAC↓, 8,   HDAC1↓, 3,   HDAC2↓, 5,   HDAC3↓, 3,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-21↓, 1,   miR-22↑, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   OCT4↓, 4,   other?, 1,   other↓, 5,   other↑, 7,   other↝, 1,   PAX2↓, 1,   PhotoS↑, 1,   SOX2↓, 1,   SOX9↓, 1,   TET3↑, 1,   tumCV?, 1,   tumCV↓, 19,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 5,   eIF2α↑, 3,   p‑eIF2α↑, 1,   ER Stress↑, 14,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 5,   HSPs↑, 2,   NQO2↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 7,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 3,   MitoP↑, 1,   p62↓, 2,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 14,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↓, 2,   DNAdam↑, 22,   DNArepair↑, 1,   hTERT/TERT↓, 2,   P53↓, 2,   P53↑, 40,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 8,   cl‑PARP↓, 1,   cl‑PARP↑, 16,   PCNA↓, 13,   SIRT6↓, 1,   Telomerase↓, 3,   TOP1↓, 3,   TOP2↓, 3,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 1,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 12,   CDK2↑, 2,   CDK4↓, 16,   CDK6↓, 3,   CDK6↑, 1,   CDKN1C/p57↑, 1,   CHK1↓, 1,   Chk2↓, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 21,   cycE/CCNE↓, 4,   cycE/CCNE↑, 1,   E2Fs↓, 2,   GADD45A↑, 1,   Ki-67↓, 8,   mitA↑, 1,   P21↓, 2,   P21↑, 21,   p27/CDKN1B↑, 10,   pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 63,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs↓, 5,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 2,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 6,   IGFBP3↑, 1,   Ki-67↓, 8,   mTORC1↓, 1,   Nanog↓, 2,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↓, 4,   NOTCH1↑, 1,   Shh↓, 2,   Smo↓, 1,   TumCG↓, 17,   TumCG↑, 2,   TumCP↓, 44,   tyrosinase↓, 1,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   ATPase↓, 1,   AXL↓, 2,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↑, 6,   Ca+2↝, 1,   i-Ca+2↑, 2,   cal2↓, 1,   CD11b↑, 1,   Cdc42↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 12,   EMT↓, 19,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 1,   FAK↓, 5,   p‑FAK↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   LAMs↓, 1,   LRP1↓, 1,   LRP1↑, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 2,   MMP13↓, 2,   MMP2↓, 23,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 28,   MMP9↑, 2,   MMPs↓, 10,   MTA1↓, 1,   N-cadherin↓, 11,   PDGF↓, 2,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   Rho↝, 1,   ROCK1↓, 2,   Slug?, 1,   Slug↓, 1,   Smad1↓, 1,   Smad1↑, 1,   Snail?, 1,   Snail↓, 3,   TET1↑, 3,   TGF-β↓, 3,   TIMP1↑, 4,   TIMP2↓, 2,   TIMP2↑, 4,   TIMP3↑, 1,   TumCI↓, 21,   TumCMig↓, 21,   TumMeta↓, 21,   TumMeta↑, 2,   Twist↓, 6,   Tyro3↓, 1,   uPA↓, 2,   uPAR↓, 1,   Vim↓, 10,   Vim↑, 1,   Zeb1↓, 2,   ZEB2↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 27,   angioG↑, 1,   CD31/PECAM-1↓, 2,   HIF-1↓, 2,   Hif1a↓, 21,   Hif1a↑, 1,   NO↓, 4,   NO↑, 3,   VCAM-1↓, 1,   VEGF↓, 35,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB∅, 1,   CLDN1↓, 2,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   MMP↓, 39,   MMP↑, 2,   NHE1↓, 1,   TRPM7↓, 1,   TRPV1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 4,   CD47↓, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 32,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCR4↓, 4,   DR4↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 4,   IFN-γ↓, 3,   IL1↓, 4,   IL1↑, 1,   IL10↑, 2,   IL1β↓, 6,   IL2↓, 2,   IL2↑, 3,   IL4↓, 2,   IL4↑, 2,   IL6↓, 22,   IL8↓, 6,   Imm↑, 3,   Imm↝, 1,   Inflam↓, 11,   Inflam↑, 1,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MIP2↓, 1,   NF-kB↓, 42,   NF-kB↑, 2,   p‑NF-kB↑, 1,   NK cell↑, 6,   NLRP3↓, 2,   NLRP3↑, 2,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 6,   PGE1↓, 1,   PGE2↓, 10,   PSA↓, 3,   PSA∅, 1,   RAGE↓, 1,   Resistin↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 3,   TNF-α↓, 20,   TNF-α↑, 3,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,   pH∅, 1,   e-pH↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   PRNP↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6,   ERα/ESR1↓, 2,   Estro↝, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARγ↓, 1,   PPARγ↑, 3,   PPARγ↝, 1,   PR↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12,   BioAv↑, 8,   BioAv↝, 5,   ChemoSen↑, 52,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A2↓, 1,   DDS↑, 1,   Dose↑, 2,   Dose↝, 22,   Dose∅, 3,   eff↓, 12,   eff↑, 29,   eff↝, 3,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P-gp/ABCB1↑, 1,   P450↓, 2,   RadioS↑, 17,   selectivity↓, 1,   selectivity↑, 34,   Synergy↑, 38,   TET2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 3,   AR↓, 6,   AST↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 1,   BRAF↑, 1,   BRAF↝, 1,   BRCA1↑, 1,   BUN↓, 1,   CEA↓, 2,   creat↓, 1,   CRP↓, 1,   EGFR↓, 9,   EGFR↑, 2,   p‑EGFR↓, 1,   ERα/ESR1↓, 2,   EZH2↓, 2,   FOXM1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 2,   IL6↓, 22,   KRAS↓, 1,   LDH↓, 2,   LDH↝, 1,   NSE↓, 1,   PD-L1↓, 6,   PSA↓, 3,   PSA∅, 1,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 28,   antiNeop↑, 1,   AntiTum↑, 5,   Appetite↑, 1,   BowelM↑, 1,   cachexia↓, 2,   cardioP↑, 10,   chemoP↑, 19,   chemoPv↑, 5,   ChemoSideEff↓, 1,   cognitive↑, 3,   fatigue↓, 1,   hepatoP↑, 10,   Mucositis↓, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   OS↑, 9,   Pain↓, 3,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 6,   radioP↑, 10,   RenoP↑, 5,   Risk↓, 6,   Sleep↑, 2,   toxicity↓, 4,   toxicity↝, 2,   TumVol↓, 12,   TumW↓, 2,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 671

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx?, 2,   antiOx↓, 2,   antiOx↑, 128,   ARE↑, 5,   Bil↓, 1,   Bil↑, 1,   Catalase↓, 9,   Catalase↑, 265,   Catalase↝, 2,   Copper↓, 1,   Fenton↓, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 5,   GPx↑, 120,   GPx↝, 1,   GPx1↑, 5,   GPx3↑, 1,   GPx4↓, 1,   GPx4↑, 5,   GSH↓, 4,   GSH↑, 131,   GSH∅, 1,   GSH/GSSG↓, 1,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 25,   GSTs↓, 1,   GSTs↑, 36,   H2O2↓, 11,   HDL↓, 1,   HDL↑, 5,   HO-1↓, 3,   HO-1↑, 74,   HO-1⇅, 1,   Iron↓, 2,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 5,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 88,   MDA↓, 108,   MDA↑, 4,   MPO↓, 6,   MPO↑, 1,   NADH↓, 1,   NOX↓, 3,   NOX4↓, 3,   NQO1↑, 15,   Nrf1↑, 2,   NRF2↓, 4,   NRF2↑, 112,   Prx↑, 4,   RNS↓, 5,   ROMO1↑, 1,   ROS?, 2,   ROS↓, 220,   ROS↑, 4,   ROS⇅, 1,   ROS∅, 2,   mt-ROS?, 1,   mt-ROS↓, 3,   SAM-e↑, 1,   SOD?, 2,   SOD↓, 7,   SOD↑, 220,   SOD↝, 2,   SOD1↑, 9,   SOD2↑, 7,   TAC↑, 18,   TBARS↓, 5,   TBARS↑, 1,   Thiols↑, 3,   TOS↓, 1,   Trx↓, 1,   Trx↑, 3,   Trx1↑, 3,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 8,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   EGF↓, 1,   ETC↑, 1,   HSP60/HSPD1↓, 1,   Insulin↑, 3,   MFN1↑, 1,   MFN2↑, 1,   mtDam↓, 7,   NGB↑, 1,   OCR↑, 1,   OPA1↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 3,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 6,   ACC↓, 1,   ACC↑, 1,   mt-ACC⇅, 1,   ACSL4↓, 1,   ALAT↓, 35,   ALAT↑, 1,   ALAT∅, 1,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 9,   ATP↑, 13,   ATP↝, 1,   Buty↑, 1,   cAMP↑, 1,   CRM↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 2,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 6,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 3,   Glycolysis↝, 1,   GSK‐3β↓, 12,   GSK‐3β↑, 1,   H2S↑, 2,   HK2↓, 1,   HK2↑, 1,   HMG-CoA↓, 2,   IDH1↑, 1,   LDL↓, 14,   NAD↑, 2,   NAD↝, 1,   NADPH↓, 8,   NADPH↑, 7,   NADPH∅, 1,   PDKs↑, 1,   PFK↓, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↑, 15,   SREBP1/SREBF1↓, 1,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 22,   ASC↓, 1,   ASK1↓, 1,   BAD↓, 1,   BAX↓, 19,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-2↑, 16,   Bcl-2↝, 1,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 28,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp8↓, 1,   Casp9↓, 9,   Cyt‑c↓, 4,   Fas↓, 1,   Ferroptosis↓, 5,   GranB/GZMB↓, 1,   iNOS↓, 32,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 6,   p38↑, 1,   p‑p38↓, 1,   survivin↓, 1,   TUNEL↓, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 14,   p‑Akt↓, 1,   p‑Akt↑, 3,   CREB↑, 1,   p‑CREB↑, 3,   ERK↓, 6,   ERK↑, 4,   p‑ERK↓, 2,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   Hippo↑, 1,   IKKα↓, 1,   IKKα↑, 1,   IκB?, 1,   JAK2↓, 2,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 9,   JNK↑, 1,   p‑JNK↓, 5,   MAPK↓, 12,   MAPK↑, 2,   MAPK↝, 1,   p‑MAPK↓, 1,   mTOR↓, 4,   mTOR↑, 6,   p‑mTOR↓, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PFKFB2↓, 1,   PI3K↓, 4,   PI3K↑, 13,   p‑PI3K↓, 1,   PKCδ↑, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 2,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF4↓, 2,   cJun↓, 1,   cMyc↓, 1,   FOXO1↝, 1,   FOXO3?, 1,   FOXO3↑, 3,   HDAC↓, 1,   miR-34a↓, 1,   other↓, 6,   other↑, 14,   other↝, 5,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 4,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 5,   HSPs↑, 1,   PERK↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 1,   p62↑, 4,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 14,   P53↓, 2,   PARP↓, 1,   PARP1↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↑, 1,   Diff↝, 1,   IGF-1↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 1,   NOTCH1↑, 1,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 3,   AP-1↑, 1,   BACH1↓, 1,   Ca+2↓, 10,   Ca+2↑, 1,   Ca+2↝, 1,   i-Ca+2↓, 1,   Cartilage↑, 2,   COL1↓, 2,   COL1↑, 2,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 7,   MMPs↓, 5,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   serineP↓, 1,   TGF-β↓, 5,   TGF-β↑, 3,   TGF-β1↓, 2,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 2,   TXNIP↑, 1,   Vim↓, 2,   α-SMA↓, 6,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 2,   LOX1↓, 2,   NO↓, 33,   NO↑, 6,   TXA2↓, 1,   VCAM-1↓, 5,   VEGF↓, 4,   VEGF↑, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 2,   BBB↑, 19,   BBB↝, 1,   CLDN1↓, 1,   GastroP↑, 5,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 6,   MMP↓, 2,   MMP↑, 24,   OCLN↓, 1,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 3,   TRPM7⇅, 1,   TRPV3↑, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2↓, 58,   COX2/PTGS2↑, 2,   CXCc↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 6,   IFN-γ↓, 5,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 10,   IL10↑, 14,   IL12↓, 4,   IL12↑, 1,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 70,   IL1β↑, 1,   IL2↓, 4,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL4↓, 8,   IL4↑, 4,   IL5↓, 2,   IL6↓, 64,   IL6↑, 5,   IL8↓, 7,   IL8↑, 1,   Imm↑, 10,   INF-γ↓, 2,   Inflam↓, 148,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MyD88↓, 2,   NeuroI↓, 4,   NF-kB↓, 78,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 15,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 19,   PGE2↑, 3,   RAGE↓, 4,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 19,   TNF-α↓, 95,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 2,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 6,   Ach↑, 5,   AChE↓, 40,   AChE↑, 1,   ADAM10↑, 2,   BChE↓, 8,   BDNF↑, 26,   BDNF∅, 1,   ChAT↑, 5,   EndoR↑, 1,   GABA↓, 2,   GABA↑, 3,   MAOA↓, 5,   MAOB↓, 1,   monoA↓, 1,   monoA↑, 1,   NGF↑, 5,   PSD95↑, 2,   RELN↑, 1,   SNAP25↑, 2,   TPH1↓, 1,   TrkB↑, 4,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   APP↓, 6,   Aβ↓, 42,   Aβ42↓, 3,   BACE/β-secretase↓, 10,   PSEN1/PS1↓, 1,   tau↓, 8,   p‑tau↓, 10,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,   cortisol↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 4,   GR↝, 1,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 5,   testos↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 22,   BioAv↑, 50,   BioAv⇅, 1,   BioAv↝, 21,   BioEnh↑, 3,   ChemoSen↑, 1,   CompStab↑, 3,   CYP2D6↓, 1,   CYP2E1↓, 2,   CYP3A2↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose↝, 29,   eff↑, 21,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 6,   Half-Life↓, 1,   Half-Life↑, 2,   Half-Life↝, 8,   P-gp/ABCB1↓, 2,   P450↓, 2,   P450↑, 2,   selectivity↑, 1,   Synergy↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 35,   ALAT↑, 1,   ALAT∅, 1,   ALP↓, 14,   AST↓, 37,   AST↑, 1,   AST∅, 1,   BG↓, 4,   Bil↓, 1,   Bil↑, 1,   BloodF↑, 2,   BMD↑, 3,   BP↓, 11,   BP∅, 1,   BUN?, 1,   BUN↓, 5,   Calcium↑, 1,   creat↓, 10,   CRP↓, 7,   hs-CRP↓, 1,   IL6↓, 64,   IL6↑, 5,   LDH↓, 12,   LDH↑, 2,   Mag↑, 1,   NOS2↓, 2,   RAGE↓, 4,   SpO2↑, 1,   TG/TAG↓, 2,   Urea↓, 4,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll?, 1,   antiAll↑, 17,   AntiArt↑, 8,   AntiCan↑, 18,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 25,   antiM↑, 1,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 3,   antiPy↑, 1,   AntiTum↑, 1,   ANXi↓, 1,   cardioP?, 1,   cardioP↑, 54,   CardioT↓, 1,   chemoP↑, 11,   chemoPv↑, 2,   ChemoSideEff↓, 1,   cognitive↓, 2,   cognitive↑, 53,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 58,   Learn↑, 6,   memory↑, 50,   Mood↑, 1,   motorD↓, 1,   motorD↑, 10,   Mucositis↓, 2,   neuroP?, 1,   neuroP↑, 110,   NP/CIPN↓, 1,   Obesity↓, 10,   OS↑, 2,   Pain↓, 7,   QoL↑, 2,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 26,   Risk↓, 3,   Sleep↑, 3,   Strength↑, 3,   Stroke↓, 9,   toxicity?, 2,   toxicity↓, 23,   toxicity↑, 4,   toxicity↝, 6,   toxicity∅, 5,   Weight↓, 2,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 9,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 12,   AntiFungal↑, 4,   AntiP↑, 2,   AntiViral↑, 8,   Bacteria↓, 17,   Diar↓, 3,   GutMicro↑, 26,   Inf↓, 1,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 1,   Ingr↝, 4,   Phen↑, 1,   QC↑, 1,  
Total Targets: 602

Scientific Paper Hit Count for: Catalase, Catalase
18 Thymoquinone
13 Magnetic Fields
13 Curcumin
12 Hydrogen Gas
11 Luteolin
10 Silver-NanoParticles
10 Lycopene
9 Melatonin
9 Quercetin
8 Resveratrol
8 Carvacrol
8 Ferulic acid
7 Boron
7 Chrysin
7 Silymarin (Milk Thistle) silibinin
6 Selenium NanoParticles
6 Moringa oleifera
6 Rosmarinic acid
5 Apigenin (mainly Parsley)
5 Propolis -bee glue
5 Crocetin
5 EGCG (Epigallocatechin Gallate)
5 Hyperoside
4 Alpha-Lipoic-Acid
4 Radiotherapy/Radiation
4 Betulinic acid
4 Chlorogenic acid
4 Chemotherapy
4 Eugenol
4 Gallic acid
4 Morin
4 Sulforaphane (mainly Broccoli)
4 Urolithin
4 Vitamin C (Ascorbic Acid)
3 Ascorbyl Palmitate
3 Capsaicin
3 doxorubicin
3 D-limonene
3 Fisetin
3 Isoliquiritigenin
3 Licorice
3 Pterostilbene
3 Shikonin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 Selenium
2 Boswellia (frankincense)
2 α-Bisabolol / Chamomile oil
2 buckwheat sprouts
2 Thymol-Thymus vulgaris
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Carvone
2 Copper and Cu NanoParticles
2 Date Fruit Extract
2 Sesame seeds and Oil
2 Shilajit/Fulvic Acid
2 Cisplatin
2 Graviola
2 HydroxyCitric Acid
2 Hibiscus sabdariffa
2 Honokiol
2 isoquercitrin
2 Kaempferol
2 Magnolol
2 Matrine
2 Magnetic Field Rotating
2 Methylsulfonylmethane
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Piperine
2 Piperlongumine
2 salinomycin
2 Selenite (Sodium)
1 1,8-Cineole
1 5-Aminolevulinic acid
1 Annona atemoya Seed Extract
1 Photodynamic Therapy
1 Allicin (mainly Garlic)
1 Andrographis
1 Astaxanthin
1 Aloe anthraquinones
1 Beta-Caryophyllene
1 Bacopa monnieri
1 Bromelain
1 Caffeic acid
1 chaetocin
1 Ginkgo biloba-EGb 761
1 Emodin
1 Exercise
1 Formononetin
1 Fucoidan
1 Germanium inorganic
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Zinc
1 Germacranolide sesquiterpene lactone
1 Orlistat
1 Hydroxycinnamic-acid
1 Isobavachalcone
1 Inositol
1 Butein
1 Scopoletin
1 isoorientin
1 Ivermectin
1 Juglone
1 Linalool
1 Mung Bean Sprouts
1 Methyl Jasmonate
1 Metformin
1 Magnesium
1 Lemon Balm/Melissa officinalis
1 Oleuropein
1 HydroxyTyrosol
1 Propyl gallate
1 Parthenolide
1 Oxygen, Hyperbaric
1 Taurine
1 5-fluorouracil
1 Turmerones
1 Ursolic acid
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:46  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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