MDA Cancer Research Results

MDA, Serum malondialdehyde: Click to Expand ⟱
Source:
Type:
MDA : malondialdehyde. The level of oxidative stress can be measured by assessing the MDA levels.
Since MDA is highly cytotoxic and carcinogenic agent it is frequently used as a biomarker of oxidative stress during major health problems such as cancer, etc.
Malondialdehyde (MDA) is the most widely used agent to estimate the extent of lipid peroxidation. Timely diagnosis of the condition followed by supplementation with antioxidants like beta-carotene, pro-vitamin A, vitamin A, vitamin C, vitamin E, lipoic acid, zinc, selenium, and spirulina can prevent potentially malignant disorders.
MDA is a lipid peroxidation marker
Scientific Papers found: Click to Expand⟱
8069- KAE,    Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *Learn↑, *memory↑, *SOD↑, *GSH↑, *TNF-α↓, *MDA↓,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8054- KAE,    Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway
- vitro+vivo, AD, NA
*AKR1B10↝, *MDA↓, *ROS↓, *GSH↑, *SOD↑, *GPx4↑, *NQO1↑, *xCT/SLC7A11↑, *NRF2↑, *HO-1↑, *cognitive↑, *Aβ↓, *p‑tau↓, *Ferroptosis↓, *AKR1C3/17β-HSD5/PGF Synthase↑, *AKR1B1/ALR2↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
9062- L-THE,    Therapeutic Role of l‑Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *AntiAge↑, *Dose?, *AMPK↑, *LC3II↑, *Beclin-1/ATG6↑, *p‑Akt↓, *p‑mTOR↓, *BDNF↑, *Casp3↓, *GSH↑, *MDA↓, *TNF-α↓, *Aβ↓, *Learn↑, *memory↑, *ROS↓,
9064- L-THE,    L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice
- in-vivo, Stroke, NA
*Stroke↓, *Bcl-2↑, *BAX↓, *Casp3↓, *ROS?, *MDA?, *NO?, *TAC↑, *GSH↑, *SOD↑, *cardioP↑, *JAK2↑, *STAT3↑,
9066- L-THE,    Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters
- in-vivo, CRC, NA
*antiOx↑, *Inflam↓, Dose↝, Weight↑, TumVol↓, PGE2↓, COX2/PTGS2↓, MPO↓, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↑, *LDH↓, *CEA↓, *MAPK↓, *Casp3↓, *Casp9↓, *Casp8↓, chemoP↑,
9009- L-THE,    Therapeutic Role of l-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *AntiAge↑, *Dose↝, *AMPK↑, *LC3II↑, *Beclin-1/ATG6↑, *p‑Akt↓, *p‑mTOR↓, *BDNF↑, *Casp3↓, *GSH↑, *MDA↓, *TNF-α↓, *Aβ↓, *Learn↑, *memory↑, *ROS↓,
9007- L-THE,    L-theanine's therapeutic effects on colorectal cancer: Mechanistic insights from a 1,2-dimethylhydrazine-induced rat model
- in-vivo, CRC, NA
CRP↓, AFP↓, CEA↓, CA19-9↓, Ki-67↓, Apoptosis↑, Casp3↑, cl‑Casp3↑, BAX↑, Bcl-2↓, *ROS↓, *Inflam↓, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *IL1β↓, *TNF-α↓, *IL6↓, *IL10↓, *COX2/PTGS2↓, *NF-kB↓, *NLRP3↓, *GutMicro↑, *chemoPv↑, *Dose↝, Ki-67↓,
8245- LCA,    Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity
- in-vivo, LiverDam, NA
*hepatoP↑, *Apoptosis↓, *mtDam↓, *ROS↓, *NRF2↑, *Keap1↓, *ARE↑, *ALAT↓, *AST↓, *MDA↓, *MPO↓, *SOD↑, *GSH/GSSG↑, *Bcl-2↑, *BAX↓, *cl‑Casp3↓, *p‑cJun↓, *AIF↓, *Cyt‑c↓,
8206- LCA,    Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways
- in-vivo, GC, BGC-823
ROS?, Casp3↑, cl‑PARP↑, eff↓, ERK↑, JNK↑, MAPK↑, AntiP↑, AntiTum↑, TumCP↓, selectivity↑, GSH/GSSG↓, MDA↑, lipid-P↑, PI3K↓, Akt↓,
8287- LE,    New insights into the antioxidant and apoptotic potential of Glycyrrhiza glabra L. during hydrogen peroxide mediated oxidative stress: An in vitro and in silico evaluation
- in-vitro, Nor, NA
*antiOx↑, *MDA↓, *lipid-P↓, *SOD?, *Catalase↑, *GSTs↑, *GPx↑, *GR↑, selectivity↑, tumCV↓, Casp8↑, Casp3↑, Bcl-2↓,
8274- LE,    Research on the Antiaging Activity of Licorice Water Extract in Aging Mice via Antioxidation, Neuronal Protection, Gut Microbiota Restoration, and PI3K/AKT/mTOR Modulation
- in-vivo, Nor, NA
*AntiAge↑, *GutMicro↑, *p‑PI3K↓, *p‑Akt↓, *p‑mTOR↓, *antiOx?, *cognitive↑, *Dose↝, *GPx↑, *Catalase↑, *SOD↑, *MDA↓, *memory↑,
8145- LF,    Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review
- Review, AD, NA - Review, Park, NA
*AntiBio↑, *Imm↑, *AntiCan↑, *neuroP↑, *BBB↑, *APOE4↓, *ROS↓, *Inflam↓, *Apoptosis↓, *Learn↑, *memory↑, *ADAM10↑, *PSEN1/PS1↑, *cl‑APP↑, *BACE/β-secretase↓, *cognitive↑, *MDA↓, *IL6↓, *TNF-α↓, *neuroP↑, *Dose↝, *IronCh↑, *SOD↑, *BioAv↝,
8295- lign,    Distribution, biosynthesis and therapeutic potential of lignans
- Review, Var, NA
*Ingr?, *BioAv↝, *antiOx↑, *AntiCan↑, *Inflam↓, *other?, Dose↝, AntiTum↑, pS2/TFF1↓, Bcl-2↓, IGF-1R↓, *radioP↑, *HO-1↑, GSTM1↑, NQO1↑, ChemoSen↑, *AntiDiabetic↑, *glucose↓, *GSH↑, *SOD↑, *MDA↓, *NO↓, *Bacteria↓, *AntiFungal↑,
8327- LIN,    Recent updates on bioactive properties of linalool
- Review, Var, NA
*AntiCan↑, *AntiBio↑, *neuroP↑, *Stress↓, *hepatoP↑, *RenoP↑, *ROS↓, ROS↑, *Inflam↓, *toxicity↓, TumCP↓, TumCCA↑, mtDam↑, MMP↓, compI↓, compII↓, ETC↓, ATP↓, angioG↓, ChemoSen↑, *GSH↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ALAT↓, *AST↓, chemoP↑,
8320- LIN,    Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways
- in-vivo, Nor, NA
RenoP↑, Dose↝, *TLR4↓, *MyD88↓, *TRIF↓, *TNF-α↓, *IL1β↓, *IL6↓, *NF-kB↓, *chemoP↑, *Casp3↓, *Casp9↓, *BAX↓, *Bcl-2↑, ChemoSen↑, *cardioP?, *hepatoP↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *ROS↓, *BUN?, *creat↓, *GSH↑, *SOD↑, *Catalase↑, *MDA↓, *NADPH↓, *NRF2↑, *HO-1↑,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
8370- LT,    Luteolin Induces GPX4-dependent Ferroptosis and Enhances Immune Activation in Colon Cancer
- vitro+vivo, Colon, NA
TumCP↓, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, Ferroptosis↑, pol-M1↑, CD8+↑, Imm↑,
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,
8398- LT,    Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiCan↑, *hepatoP↑, *neuroP↑, *cardioP↑, *neuroG↑, *BBB↑, *ROS↓, *AChE↓, *p‑T-cadherin↓, *Aβ↓, *memory↑, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *RANTES↓, *BioAv↑, *Half-Life↝, *toxicity↓, *BACE/β-secretase↓, *Aβ42↓, *COX2/PTGS2↓, *Bcl-2↓, *Casp3↓, *BAX↓, *GSTs↓, *lipid-P↓, *Casp3↓, *Casp9↓, *memory↑, *GSK‐3β↓, *ChAT↑, *SOD↑, *GPx↑, *MDA↓, *ER Stress↓, *GRP78/BiP↓, *NRF2↑, *motorD↑, *antiAll↑,
1275- LT,    Mechanism of luteolin induces ferroptosis in nasopharyngeal carcinoma cells
- in-vitro, Laryn, NA
Ferroptosis↑, MDA↑, Iron↑, SOD↓, GSH↓, GPx4↓, SOX4↓, GDF15↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
4231- LT,    Luteolin and its antidepressant properties: From mechanism of action to potential therapeutic application
- Review, AD, NA
*PSD95↑, *BDNF↑, *SOD↑, *GSTA1↑, *MDA↑, *Casp3↓, *Mood↑, *antiOx↑, *Apoptosis↓, *Inflam↓, *ER Stress↓,
3828- Lyco,    Lycopene alleviates oxidative stress via the PI3K/Akt/Nrf2pathway in a cell model of Alzheimer's disease
- in-vitro, AD, M146L
*ROS↓, *PI3K↑, *Akt↑, *NRF2↓, *antiOx↑, *BACE/β-secretase↓, *MDA↓,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1/SREBF1↓, *FASN↓, *ACC↓,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
8419- Lyco,    Brain-targeted lycopene-loaded microemulsion modulates neuroinflammation, oxidative stress, apoptosis and synaptic plasticity in β-amyloid-induced Alzheimer’s disease mice
- in-vivo, AD, NA
*neuroP↑, *Aβ↓, *MDA↓, *Astr↓, *MGlio↓, *antiOx↑,
8412- Lyco,    Brain-targeted lycopene-loaded microemulsion modulates neuroinflammation, oxidative stress, apoptosis and synaptic plasticity in β-amyloid-induced Alzheimer's disease mice
- in-vivo, AD, NA
*MDA↓, *antiOx↑, *eff↑,
8416- Lyco,    Lycopene alleviates cognitive dysfunctions in an Alzheimer's disease rat model via suppressing the oxidative and neuroinflammatory signaling
- in-vivo, AD, NA
*Inflam↓, *ROS↓, *Dose↝, *Aβ42↓, *IL1β↓, *TNF-α↓, *MDA↓, *Ach↑, *MAOA↓, *LDH↓, *AChE↓, *NRF2↑, *5HT↑, *TGF-β1↑, *IL10↑, *Ki-67↓, *PCNA↓,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
8413- Lyco,  VitE,    Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation
- in-vivo, AD, NA
*memory↑, *MDA↓, *GPx↑, *tau↓, *Synergy↑,
4228- Lyco,    A review for the pharmacological effect of lycopene in central nervous system disorders
- Review, AD, NA - Review, Park, NA
*cognitive↑, *memory↑, *Inflam↓, *Apoptosis↓, *ROS↓, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *MDA↓, *GPx↑,
4803- Lyco,    Enhanced cytotoxic and apoptosis inducing activity of lycopene oxidation products in different cancer cell lines
- in-vitro, Pca, PC3 - in-vitro, BC, MCF7 - in-vitro, Melanoma, A431 - in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa - in-vitro, Lung, A549
tumCV↓, GSH↓, MDA↑, ROS↑, Apoptosis↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
8522- MAG,    Effects of magnolol on impairment of learning and memory abilities induced by scopolamine in mice
- in-vivo, AD, NA
*Learn↑, *memory↑, AChE↓, NOS2↑, SOD↑, MDA↓,
4529- MAG,    Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review
- Review, Diabetic, NA
*AntiDiabetic↑, *glucose↓, *SOD↑, *Catalase↑, *ROS↓, *MDA↓, *GPx↑, *CYP2E1↓, *AGEs↓, *IL10↑, *neuroP↑, *GutMicro↑,
8541- Matr,    Matrine induces ferroptosis and suppresses colorectal cancer through targeting the STAT3/SLC7A11 pathway
- in-vivo, CRC, NA
TumCP↓, necrosis↑, Ferroptosis↑, TumCD↑, lipid-P↑, MDA↑, GSH↓, xCT/SLC7A11↓, P53↑, p‑STAT3↓,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8552- Matr,    Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways
- Review, AD, NA
*BBB↑, *neuroP↑, *HMGB1↓, *NF-kB↓, *MyD88↓, *TLR4↓, *TRAF6↓, *Cyt‑c↓, *MDA↓, *Beclin-1/ATG6↑, *GPx↑, *IL23↓, *IL17↓, *NRF2↑, *HO-1↑, *SOD↑, *GSH↑, *Stroke↓, *BACE/β-secretase↓, *Aβ↓, *BDNF↑, *AChE↓, *BChE↓, *ROS↓, *memory↑, *NP/CIPN↓,
8549- Matr,    Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis
- in-vitro, Var, NA
toxicity↑, *hepatoP↓, *SOD↓, *GSH↓, *MDA↑, *ROS↑, *lipid-P↑, *Iron↝, *Ferroptosis↑, *FTH1↓, *NRF2↓, *xCT/SLC7A11↓, *GPx4↓, *HO-1↓, *toxicity↝,
1204- MET,    Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
MDA↑, ROS↑, Iron↑, GSH↓, T-SOD↓, Catalase↓, GPx4↓, xCT/SLC7A11↓, NRF2↓, HO-1↓,
8489- MF,    Pulsed electromagnetic fields induce ferroptosis in osteosarcoma cells and promote osteogenic differentiation
- in-vitro, OS, U2OS - in-vitro, OS, MG63
TumCP↓, TumCMig↓, Ferroptosis↑, GPx4↓, xCT/SLC7A11↓, BMD↑, selectivity↑, Dose↝, TumCG↓, Dose↝, OS↑, ROS↑, MDA↑, Iron↑, ChemoSen↑, TOP2↑, radioP↑,
4103- MF,    Comparing the Effects of Long-term Exposure to Extremely Low-frequency Electromagnetic Fields With Different Values on Learning, Memory, Anxiety, and β-amyloid Deposition in Adult Rats
- in-vivo, Nor, NA
*Dose↝, *memory↑, *ROS↑, *MDA↑,
3462- MF,    The Effect of a Static Magnetic Field on microRNA in Relation to the Regulation of the Nrf2 Signaling Pathway in a Fibroblast Cell Line That Had Been Treated with Fluoride Ions
- in-vitro, Nor, NA
*NRF2↑, *Keap1↓, *SOD↑, *GPx↑, *ROS↓, *MDA↓, *SOD1↑, *SOD2↑, *GSR↑,
3463- MF,    Pulsed Electromagnetic Fields Alleviates Hepatic Oxidative Stress and Lipids Accumulation in db/db mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *GSSG↓, *GSH↑, *GPx↑, *antiOx↑, *SREBP1/SREBF1↓,
3498- MF,    Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues
- in-vitro, GC, NA
*SOD↑, *MDA↓, SOD↓, GPx↓, MDA↑, Catalase↑,
209- MFrot,  MF,    The effect of a rotating magnetic field on the antioxidant system in healthy volunteers - preliminary study
- Human, Nor, NA
*SOD↑, *Catalase↑, *ROMO1↑, *MDA↓, *TAC↑, *ROS↓,

Showing Research Papers: 201 to 250 of 363
Prev Page 5 of 8 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 363

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↓, 11,   Catalase↑, 12,   Fenton↑, 2,   GCLM↓, 1,   GPx↓, 3,   GPx↑, 7,   GPx4↓, 30,   GPx4↑, 1,   GSH↓, 50,   GSH↑, 10,   GSH/GSSG↓, 2,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 3,   HO-1↓, 6,   HO-1↑, 11,   Iron↑, 25,   Iron↝, 1,   i-Iron↑, 3,   Keap1↑, 3,   lipid-P↓, 3,   lipid-P↑, 23,   MDA?, 1,   MDA↓, 23,   MDA↑, 63,   i-MDA↑, 4,   MPO↓, 2,   NADH↓, 1,   NADPH/NADP+↓, 1,   NFE2L2↑, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 2,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 14,   NRF2↑, 11,   OSI↑, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 14,   ROS↑, 94,   ROS⇅, 1,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 14,   SOD↑, 17,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   T-SOD↓, 1,   TAC↓, 2,   TAC↑, 1,   TBARS↓, 1,   TOS↑, 2,   TrxR↓, 2,   uricA↓, 1,   xCT/SLC7A11↓, 8,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FTH1↓, 6,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   NCOA4↑, 3,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   compI↓, 1,   compII↓, 1,   compIV↓, 1,   EGF↓, 1,   ETC↓, 2,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mtDam↑, 11,   OXPHOS↓, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACSL4↑, 3,   ALAT↓, 4,   AMPK↓, 1,   AMPK↑, 8,   p‑AMPK↑, 2,   ATP↓, 7,   mt-ATP↓, 1,   citrate↓, 1,   FASN↓, 3,   G6PD↓, 2,   GAPDH↓, 1,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 9,   GSK‐3β↓, 1,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   HK2↓, 6,   lactateProd↓, 4,   lactateProd↑, 1,   LDHA↓, 3,   NAD↝, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFKP↓, 1,   PKM2↓, 2,   PKM2↑, 1,   Pyruv↓, 1,   SCD1↓, 2,   SIRT1↓, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 2,   Apoptosis↓, 3,   Apoptosis↑, 56,   mt-Apoptosis↑, 1,   BAD↑, 1,   Bak↓, 1,   Bak↑, 2,   BAX↓, 1,   BAX↑, 34,   Bax:Bcl2↑, 10,   Bcl-2↓, 36,   Bcl-xL↓, 3,   BID↑, 3,   BIM↑, 1,   Casp↑, 5,   cl‑Casp↑, 1,   Casp12↑, 1,   Casp3↓, 2,   Casp3↑, 46,   cl‑Casp3↑, 6,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp7↑, 7,   Casp8↑, 14,   Casp9↑, 25,   cl‑Casp9↑, 2,   CellShr↑, 1,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 22,   mt-Cyt‑c↓, 1,   DR5↓, 1,   DR5↑, 5,   Endon↑, 1,   FADD↑, 3,   Fas↑, 5,   FasL↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 35,   GranB/GZMB↝, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 4,   Mcl-1↓, 1,   MDM2↓, 2,   MOMP↑, 2,   necrosis↑, 2,   p38↑, 5,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 1,   Pyro↑, 2,   survivin↓, 6,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↑, 6,   XIAP↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 37,   Akt↑, 4,   p‑Akt↓, 6,   AMPKα↑, 1,   BRAF↑, 1,   BRAF↝, 1,   CaMKII ↓, 1,   cMET↓, 2,   cSrc↓, 1,   EGFR↓, 5,   EGFR↑, 1,   ERK↓, 9,   ERK↑, 3,   p‑ERK↓, 1,   ERK5↓, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 2,   IKKα↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 5,   JNK↓, 1,   JNK↑, 4,   p‑JNK↑, 1,   LIMK1↓, 1,   MAPK↓, 10,   MAPK↑, 4,   MAPK↝, 2,   p‑MEK↓, 1,   mTOR↓, 23,   mTOR↑, 1,   mTOR↝, 1,   p‑mTOR↓, 4,   P70S6K↓, 1,   PI3K↓, 31,   PI3K↑, 1,   PI3K/Akt↝, 1,   PKCδ↓, 3,   PTEN↓, 1,   PTEN↑, 3,   PTEN↝, 1,   Raf↓, 2,   RAS↓, 1,   p‑S6K↓, 2,   Sp1/3/4↓, 4,   STAT↓, 2,   STAT3↓, 22,   p‑STAT3↓, 3,   TSC2↑, 1,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 5,   ATFs↑, 1,   cJun↓, 1,   cMyc↓, 10,   DLEU1↓, 1,   DNMT1↓, 3,   DNMT1↑, 1,   DNMTs↓, 1,   EZH2↓, 3,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   FOXO4↑, 1,   HDAC↓, 2,   HDAC1↓, 2,   HDAC2↓, 2,   HDAC3↓, 2,   miR-124-3p↓, 1,   miR-21↓, 1,   miR-21↑, 1,   miR-27a-3p↓, 1,   miR-34a↓, 1,   MYCN↓, 1,   OCT4↓, 4,   other↓, 1,   other↑, 2,   other↝, 2,   PAX2↓, 1,   PhotoS↑, 1,   SOX2↓, 3,   SOX4↓, 2,   SOX9?, 1,   tumCV?, 1,   tumCV↓, 15,   USF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 6,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 11,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 2,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 5,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 10,   p‑Beclin-1/ATG6↑, 1,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 1,   LC3B↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 1,   p62↓, 1,   p62↑, 1,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↑, 12,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 18,   p16↑, 1,   P53↓, 1,   P53↑, 29,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 6,   cl‑PARP↑, 7,   cl‑PARP1↑, 1,   PCNA↓, 8,   SIRT6↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TOP2↑, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK1↑, 1,   CDK2↓, 9,   CDK2↑, 2,   CDK4↓, 11,   CDK6↓, 3,   CDK6↑, 1,   CHK1↓, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 16,   cycE/CCNE↓, 1,   Ki-67↓, 10,   mitA↑, 1,   P21↓, 1,   P21↑, 16,   p27/CDKN1B↑, 3,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   TumCCA↑, 51,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 1,   BMP7/OP1↓, 2,   CD133↑, 1,   cFos↓, 2,   CSCs↓, 7,   EIF4E↓, 1,   FGF↓, 2,   FOSL1↑, 1,   GDF15↓, 1,   Gli↓, 1,   HH↓, 2,   IGF-1↓, 3,   IGFBP3↑, 1,   Ki-67↓, 10,   Nanog↓, 4,   NOTCH↓, 2,   NOTCH↑, 1,   NOTCH1↓, 1,   NOTCH1↑, 1,   Shh↓, 1,   STAT1↓, 1,   TumCG↓, 21,   TumCP↓, 42,   Wnt↓, 8,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   AXL↓, 1,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 2,   Ca+2↑, 4,   i-Ca+2↑, 1,   COL1↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 6,   EMT↓, 19,   EMT↝, 1,   F-actin↓, 1,   FAK↓, 1,   p‑FAK↓, 2,   Fibronectin↓, 1,   LAMs↓, 2,   LRP1↑, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP2↓, 16,   MMP2↑, 1,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 23,   MMP9↑, 2,   MMPs↓, 4,   N-cadherin↓, 6,   NeuroT↓, 1,   PCBP1↓, 1,   PDGF↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug?, 1,   Slug↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 3,   TET1↑, 1,   TGF-β↓, 3,   TGF-β1↓, 1,   THBS1↓, 1,   TIMP2↓, 2,   TIMP2↑, 1,   TSP-1↑, 1,   TumCI↓, 20,   TumCMig↓, 20,   TumMeta↓, 10,   TumMeta↑, 1,   Twist↓, 3,   uPA↓, 3,   uPAR↓, 1,   Vim↓, 7,   Zeb1↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 10,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 17,   EGR1↓, 1,   Hif1a↓, 16,   Hypoxia↓, 1,   NO↓, 2,   NO↑, 3,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 25,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   BBB∅, 1,   GLUT1↓, 4,   MMP↓, 24,   MPT↑, 1,   SLC12A5↓, 1,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   CD47↓, 1,   CD8+↑, 3,   COX2/PTGS2↓, 17,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCL12↓, 1,   CXCR2↓, 1,   CXCR4↓, 3,   DR4↑, 3,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   IFN-γ↓, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL1β↓, 4,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 13,   IL8↓, 3,   Imm↑, 5,   Imm↝, 1,   Inflam↓, 5,   pol-M1↑, 2,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   NF-kB?, 1,   NF-kB↓, 25,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 4,   PGE2↓, 4,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 3,   TNF-α↓, 10,   TNF-α↑, 3,   TRADD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 4,   BNP↓, 1,   ER-α36↓, 1,   GR↑, 1,   PPARγ↓, 1,   PPARγ↑, 3,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 6,   BioAv↑, 8,   BioAv↝, 2,   BioEnh↑, 2,   chemoR↓, 1,   ChemoSen↑, 40,   CompStab↓, 1,   CompStab↝, 1,   Dose↑, 1,   Dose↝, 17,   eff↓, 13,   eff↑, 12,   eff↝, 1,   eff∅, 1,   GSTA1↓, 1,   GSTM1↑, 1,   Half-Life↓, 1,   Half-Life↝, 2,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 4,   P-gp/ABCB1⇅, 1,   RadioS↑, 10,   selectivity↑, 22,   Synergy?, 1,   Synergy↑, 24,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 4,   ALAT↓, 4,   AR↓, 4,   AST↓, 2,   BMD↑, 1,   BRAF↑, 1,   BRAF↝, 1,   BUN↓, 1,   CA19-9↓, 1,   CEA↓, 2,   creat↓, 2,   CRP↓, 2,   EGFR↓, 5,   EGFR↑, 1,   EZH2↓, 3,   Ferritin↓, 1,   Ferritin↑, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   IL6↓, 13,   LDH↓, 6,   LDH↑, 1,   NOS2↑, 1,   PD-L1↓, 4,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 1,   TP53↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 18,   antiCG↓, 1,   antiNeop↑, 1,   AntiTum↑, 5,   cachexia↓, 1,   cardioP↑, 7,   chemoP↑, 13,   chemoPv↑, 4,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 8,   memory↑, 1,   neuroP↑, 1,   NP/CIPN↓, 2,   OS↓, 1,   OS↑, 5,   Pain↓, 1,   PFS↑, 1,   QoL↑, 3,   radioP↑, 8,   RenoP↑, 8,   Risk↓, 3,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 2,   TumVol↓, 9,   TumW↓, 6,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 6,  
Total Targets: 602

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx?, 2,   antiOx↓, 6,   antiOx↑, 113,   ARE↑, 2,   Bil↑, 2,   Catalase↓, 5,   Catalase↑, 108,   Catalase↝, 1,   Copper↓, 1,   Fenton↓, 3,   GCLC↑, 3,   GCLM↑, 3,   GPx↓, 5,   GPx↑, 81,   GPx∅, 1,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 6,   GPx4∅, 1,   GSH↓, 6,   GSH↑, 136,   GSH⇅, 1,   GSH∅, 2,   GSH/GSSG↑, 2,   GSR↓, 3,   GSR↑, 9,   GSSG↓, 6,   GSTs↓, 2,   GSTs↑, 13,   H2O2↓, 9,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 5,   HDL∅, 1,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 5,   HO-1↑, 79,   HO-1⇅, 1,   HO-1∅, 1,   Iron↓, 4,   Iron↝, 1,   i-Iron↓, 3,   i-Iron↑, 1,   Keap1↓, 7,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 61,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA?, 1,   MDA↓, 269,   MDA↑, 12,   MDA∅, 1,   MPO↓, 17,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 3,   NQO1↑, 21,   NQO1↝, 1,   Nrf1↑, 1,   NRF2↓, 5,   NRF2↑, 119,   NRF2∅, 1,   p‑NRF2↑, 1,   ONOO↓, 1,   Prx↑, 3,   RNS↓, 3,   ROMO1↑, 1,   ROS?, 2,   ROS↓, 217,   ROS↑, 7,   ROS⇅, 3,   i-ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   selenoP↑, 1,   SOD?, 2,   SOD↓, 9,   SOD↑, 183,   SOD↝, 1,   mt-SOD↑, 1,   SOD1↑, 4,   SOD2↑, 2,   TAC↑, 24,   TBARS↓, 5,   Thiols↑, 2,   TOS↓, 2,   Trx↑, 2,   Trx1↑, 2,   TrxR↑, 1,   uricA↓, 3,   VitC↑, 3,   VitE↓, 1,   VitE↑, 1,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 1,   FTH1↑, 1,   FTL↓, 1,   IronCh↓, 1,   IronCh↑, 7,   Mets↝, 1,   TfR1/CD71↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   Insulin↓, 1,   Insulin↑, 2,   mtDam↓, 7,   NGB↑, 1,   OCR↑, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   ACC↓, 1,   ACSL4↓, 2,   ACSL4∅, 1,   adiP↓, 1,   ALAT↓, 38,   ALAT↑, 1,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 13,   ATP↓, 1,   ATP↑, 8,   Buty↑, 1,   cAMP↑, 2,   CRM↑, 2,   DGAT1↓, 1,   FASN↓, 4,   glucose↓, 8,   glucose↝, 1,   GlucoseCon↑, 2,   Glycolysis↑, 1,   GSK‐3β↓, 15,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 3,   HK2↑, 1,   HMG-CoA↓, 2,   LDL↓, 10,   lipidLev↓, 2,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 4,   NADPH↑, 3,   PFK↓, 1,   PFK↑, 1,   PKM2↓, 2,   PKM2↑, 1,   PLA2↓, 1,   SCFAs↑, 2,   SIRT1↓, 1,   SIRT1↑, 17,   SREBP1/SREBF1↓, 3,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 3,   APAF1↓, 1,   Apoptosis↓, 30,   Apoptosis∅, 1,   ASC↓, 1,   BAX↓, 22,   BAX↑, 2,   Bax:Bcl2↓, 2,   Bcl-2↓, 3,   Bcl-2↑, 19,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3↓, 36,   Casp3↑, 2,   cl‑Casp3↓, 5,   proCasp3↓, 1,   Casp8↓, 2,   Casp9↓, 12,   Casp9↑, 1,   Cyt‑c↓, 6,   Cyt‑c∅, 1,   Fas↓, 1,   Ferroptosis↓, 10,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   iNOS↓, 42,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 6,   p38↑, 1,   p‑p38↓, 2,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 12,   p‑Akt↓, 4,   p‑Akt↑, 2,   CREB↑, 3,   p‑CREB↑, 2,   ERK↓, 6,   ERK↑, 3,   p‑ERK↓, 2,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 2,   JAK2↓, 3,   JAK2↑, 3,   p‑JAK2↓, 1,   JNK↓, 12,   JNK↑, 1,   p‑JNK↓, 3,   MAPK?, 1,   MAPK↓, 15,   MAPK↑, 4,   p‑MAPK?, 1,   p‑MAPK↓, 2,   mTOR↓, 3,   mTOR↑, 3,   p‑mTOR↓, 4,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 13,   p‑PI3K↓, 1,   PKA↑, 1,   PKCδ↑, 1,   PP2A↑, 2,   PTEN↓, 1,   STAT↓, 1,   STAT3?, 1,   STAT3↓, 5,   STAT3↑, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   ATF4↑, 1,   cJun↓, 1,   p‑cJun↓, 1,   cMyc↓, 1,   FOXO↑, 1,   FOXO1↑, 1,   FOXO3↑, 2,   HDAC↓, 1,   other?, 3,   other↓, 7,   other↑, 14,   other↝, 5,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 7,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 11,   GRP78/BiP↓, 10,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 6,   HSP70/HSPA5↝, 1,   IRE1↓, 3,   PDI↓, 1,   PERK↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   ATG5↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3II↑, 4,   MitoP↑, 1,   p62↓, 1,   p62↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10,   P53↓, 2,   PARP1↓, 1,   PCNA↓, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 2,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↝, 1,   IGF-1↓, 1,   Ki-67↓, 2,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   TumCG↓, 1,   TumCP↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 7,   AP-1↓, 1,   BACH1↓, 1,   Ca+2↓, 9,   cal2↓, 1,   COL1↓, 3,   COL1↑, 2,   COL3A1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 2,   MMP13↓, 1,   MMP2↓, 2,   MMP2↑, 1,   MMP9↓, 8,   MMP9↑, 1,   MMPs↓, 1,   MUC1↑, 1,   ROCK1↓, 1,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TGF-β1↓, 3,   TGF-β1↑, 2,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   TXNIP↓, 3,   Vim↓, 2,   α-SMA↓, 7,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   eNOS↓, 1,   Hif1a↓, 5,   LOX1↓, 1,   NO?, 1,   NO↓, 43,   NO↑, 3,   VCAM-1↓, 8,   VEGF↓, 4,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 17,   BBB↝, 1,   BBB∅, 2,   GastroP↑, 4,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 5,   MMP↓, 1,   MMP↑, 15,   NHE3↑, 1,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 3,   TRPM7⇅, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

BALF-Infl↓, 2,   BALF-Lym↓, 1,   CD25+↑, 1,   CD4+↑, 3,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 2,   CXCL15↓, 1,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 9,   IFN-γ↓, 6,   IFN-γ↑, 2,   IgE↓, 2,   IL1↓, 3,   IL10↓, 7,   IL10↑, 17,   IL12↓, 4,   IL13↓, 2,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 73,   IL1β↑, 1,   IL2↓, 4,   IL22↓, 1,   IL23↓, 2,   IL33↓, 1,   IL4↓, 8,   IL4↑, 5,   IL5↓, 3,   IL5↑, 1,   IL6?, 1,   IL6↓, 72,   IL6↑, 3,   IL8↓, 11,   Imm↑, 10,   INF-γ↓, 3,   Inflam↓, 147,   Inflam↑, 5,   IP-10/CXCL-10↓, 2,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MIP2↓, 1,   MyD88↓, 4,   NeuroI↓, 7,   Neut↓, 1,   NF-kB↓, 77,   NK cell↑, 1,   NLRP3↓, 18,   p65↓, 4,   PGE2↓, 18,   PGE2↑, 2,   RAGE↓, 3,   RANTES↓, 2,   SOCS-3↓, 1,   Th2↓, 1,   TLR2↓, 3,   TLR4↓, 25,   TNF-α↓, 104,   TNF-α↑, 3,   TRAF1↓, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,   GFAP↓, 3,   GGT/CD224↓, 1,   MGlio↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 5,   Ach↑, 6,   AChE↓, 42,   AChE↝, 1,   ADAM10↑, 1,   BChE↓, 7,   BDNF↑, 30,   BDNF⇅, 1,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 8,   ChE↓, 1,   GABA↑, 2,   GDNF↑, 1,   MAOA↓, 4,   MAOB↓, 2,   monoA↑, 1,   NGF↑, 6,   PSD95↑, 5,   RELN↑, 1,   SNAP25↑, 2,   TPH1↓, 1,   TrkB↑, 5,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APOE4↓, 1,   APP↓, 7,   cl‑APP↑, 1,   Aβ↓, 42,   Aβ42↓, 2,   BACE/β-secretase↓, 19,   PSEN1/PS1↓, 1,   PSEN1/PS1↑, 1,   tau↓, 11,   p‑tau↓, 10,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   BNP↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↑, 2,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 25,   BioAv↑, 38,   BioAv⇅, 1,   BioAv↝, 12,   BioEnh↑, 1,   ChemoSen↑, 1,   CompStab↝, 1,   CYP2D6↓, 1,   CYP2E1↓, 3,   Dose?, 5,   Dose↓, 1,   Dose↑, 5,   Dose↝, 37,   eff↓, 4,   eff↑, 29,   eff↝, 3,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↑, 1,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 38,   ALAT↑, 1,   ALB↑, 1,   ALP↓, 6,   AST↓, 39,   AST↑, 1,   BG↓, 1,   Bil↑, 2,   BloodF↑, 1,   BMD↑, 3,   BP↓, 6,   BP↝, 1,   BP∅, 1,   BUN?, 1,   BUN↓, 6,   CEA↓, 2,   CK/CK-MB↓, 1,   creat↓, 13,   CRP↓, 13,   Ferritin↑, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 72,   IL6↑, 3,   LDH↓, 14,   LDH↑, 2,   LDH∅, 1,   NOS2↓, 3,   RAGE↓, 3,   SpO2↑, 1,   TC↓, 2,   TG/TAG↓, 3,   Urea↓, 3,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 3,   AirwayM↓, 1,   AntiAge↑, 3,   antiAll?, 1,   antiAll↑, 18,   AntiArt↑, 5,   AntiCan↑, 14,   antiCG↑, 1,   AntiDiabetic↑, 23,   antiPs↑, 3,   AntiTum↑, 1,   ANXi↓, 1,   BOLD↑, 1,   cardioP?, 1,   cardioP↑, 40,   CardioT↓, 1,   chemoP↑, 13,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 56,   cognitive∅, 1,   diuretic↑, 1,   hepatoP↓, 3,   hepatoP↑, 63,   Learn↑, 10,   memory↑, 63,   Mood↑, 4,   motorD↑, 6,   Mucositis↓, 1,   neuroP↑, 109,   NP/CIPN↓, 1,   Obesity↓, 10,   OS↑, 4,   Pain↓, 5,   QoL↑, 2,   radioP↑, 7,   RenoP↓, 1,   RenoP↑, 28,   Risk↓, 5,   Sleep↑, 3,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 13,   toxicity↓, 27,   toxicity↑, 2,   toxicity↝, 7,   toxicity∅, 5,   Weight↓, 1,   Weight↑, 3,   Weight∅, 1,   Wound Healing↑, 8,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 4,   AntiP↑, 1,   AntiViral↑, 6,   Bacteria↓, 11,   Diar↓, 3,   GutMicro↑, 28,   Inf↓, 1,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 3,   Ingr↝, 4,  
Total Targets: 611

Scientific Paper Hit Count for: MDA, Serum malondialdehyde
17 Curcumin
14 Thymoquinone
12 Hydrogen Gas
11 Silver-NanoParticles
11 Boron
11 Lycopene
11 Quercetin
10 Silymarin (Milk Thistle) silibinin
9 Luteolin
8 Magnetic Fields
7 Propolis -bee glue
6 doxorubicin
6 Betulinic acid
6 Carvacrol
6 Chlorogenic acid
6 Ferulic acid
5 Cisplatin
5 Baicalein
5 Crocetin
5 isoorientin
5 Sulforaphane (mainly Broccoli)
5 Kaempferol
5 L-Theanine
5 Matrine
5 Moringa oleifera
5 Morin
5 Shikonin
4 Resveratrol
4 Alpha-Lipoic-Acid
4 Astaxanthin
4 Berberine
4 Vitamin C (Ascorbic Acid)
4 Chrysin
4 Hyperoside
4 Rosmarinic acid
4 Rutin
3 Allicin (mainly Garlic)
3 Apigenin (mainly Parsley)
3 Melatonin
3 Radiotherapy/Radiation
3 Benzyl isothiocyanate
3 Phenethyl isothiocyanate
3 α-Bisabolol / Chamomile oil
3 Centella asiatica / Gotu kola → asiaticoside
3 Chemotherapy
3 Spirulina(Arthrospira/Limnospira)
3 EGCG (Epigallocatechin Gallate)
3 Selenium NanoParticles
3 Selenite (Sodium)
3 Vitexin
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Allyl isothiocyanate
2 borneol
2 Selenium
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Carvone
2 Copper and Cu NanoParticles
2 Chlorella (Chlorella vulgaris)
2 Dandelion Root
2 Emodin
2 Sesame seeds and Oil
2 Gallic acid
2 Graviola
2 HydroxyCitric Acid
2 Isoliquiritigenin
2 Isovitexin
2 Juglone
2 Licochalcone A
2 Licorice
2 Linalool
2 Magnolol
2 Lemon Balm/Melissa officinalis
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Piperlongumine
2 Pterostilbene
1 3-bromopyruvate
1 cetuximab
1 5-Hydroxytryptophan
1 Anthocyanins
1 Paclitaxel/Taxol
1 Baicalin
1 Biochanin A
1 Bromelain
1 Boswellia (frankincense)
1 Caffeic acid
1 Carnosic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celastrol
1 chitosan
1 Chlorophyllin
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Citric Acid
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Galantamine
1 Diclofenac
1 Docosahexaenoic Acid
1 diet Methionine-Restricted Diet
1 Diindolylmethane
1 D-limonene
1 Ellagic acid
1 Eurycomanone
1 Eugenol
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 Fucoidan
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Huperzine A/Huperzia serrata
1 Isobavachalcone
1 isoquercitrin
1 Isothiocyanates
1 Ivermectin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Vitamin E
1 Metformin
1 Magnetic Field Rotating
1 Magnesium
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 Oleuropein
1 HydroxyTyrosol
1 Aromatherapy
1 buckwheat sprouts
1 Orlistat
1 salinomycin
1 Sulfasalazine
1 Anti-oxidants
1 Date Fruit Extract
1 Sesamin
1 Lignans
1 Shankhpushpi
1 Silicic Acid
1 Safflower yellow
1 Taurine
1 5-fluorouracil
1 Urolithin
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:570  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page