TumMeta Cancer Research Results

TumMeta, Cancer Metastasis: Click to Expand ⟱
Source:
Type:
Cancer metastasis is the process by which cancer cells spread from the original (primary) tumor to other parts of the body, forming new (secondary) tumors. This occurs when cancer cells invade surrounding tissues, enter the bloodstream or lymphatic system, and travel to distant organs or tissues.


Scientific Papers found: Click to Expand⟱
7617- Ins,    miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting
- in-vitro, BC, NA
PI3K↓, Akt↓, TumMeta↓, miR-125b↝, IP6K1↓,
7660- IP,    Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans
- Review, CRC, NA
SCFAs↑, Buty↑, PA↑, TumCG↓, HDAC↓, Apoptosis↑, TumMeta↓,
7697- IP6,  Ins,    Combination of Inositol Hexaphosphate and Inositol Inhibits Liver Metastasis of Colorectal Cancer in Mice Through the Wnt/β-Catenin Pathway
- in-vivo, CRC, NA
TumMeta↓, OS↑, TumW↓, Wnt↓, TCF7/TCF1↓, cMyc↓,
7722- IP6,    Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic
- Review, Var, NA
Synergy↑, TumCP↓, Diff↑, TumCCA↑, Imm↑, antiOx↑, BioAv↑, toxicity↓, ChemoSen↑, TumMeta↓, QoL↑,
7646- IP6,  Ins,    Protection against cancer by dietary IP6 and inositol
- Review, Var, NA
*antiOx↑, TumCG↓, TumMeta↓, Imm↑, kidSt↓, LDL↓, TumCCA↑, TumCP↓, Diff↑, ChemoSen↑, QoL↑,
7699- IP6,    IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise
- Review, Var, NA
*Iron∅, ChemoSen↑, *cardioP↑, neuroP↑, IronCh∅, P21↓, p27/CDKN1B↓, p‑pRB↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TumW↓, TumCI↓, TumMeta↓, Imm↑, Diff↑, selectivity↑, toxicity↓, RenoP↑, QoL↑,
7702- IP6,  Ins,  capec,    Inositol Hexakisphosphate and Inositol Enhance the Inhibition of Colorectal Cancer Growth and Liver Metastasis by Capecitabine in a Mouse Model
- in-vivo, CRC, NA
Dose↝, AntiTum↑, OS↑, TumW↓, TumMeta↓, E-cadherin↑, N-cadherin↓, Vim↓, TNF-α↓, IL6↓, IL8↓, ChemoSen↑,
7748- ISL,  GEM,    Isoliquiritigenin combined with gemcitabine inhibited lung cancer by suppressing JAK2/STAT3 signaling via lncRNA-p21/miRNA-4534 axis
- in-vitro, Lung, NA
Dose↝, Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, P21↑, selectivity↑, JAK2↓, STAT3↓,
7762- ISL,    Isoliquiritigenin reduces brain metastasis by circNAV3-ST6GALNAC5-EGFR axis in triple-negative breast cancer
- in-vivo, BC, NA
TumMeta↓, circNAV3↓,
7735- isoFl,    Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy
- Review, Var, NA
Risk↓, ChemoSen↑, chemoP↑, RadioS↑, radioP↑, NF-kB↓, DNMTs↓, TumMeta↓, angioG↓, antiOx↑, BioAv↑, toxicity↓,
7853- isoO,    Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review
- Review, Var, NA
Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
7796- ISQ,    Isoquercitrin restrains the proliferation and promotes apoptosis of human osteosarcoma cells by inhibiting the Wnt/β-catenin pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
TumCP↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, Apoptosis↑, TumMeta↓, TumCCA↑, BAX↑, cl‑Casp3↑, Bcl-2↓,
7993- itraC,    Preclinical evaluation of itraconazole in docetaxel-resistant prostate cancer xenograft models
- in-vivo, Pca, NA
TumCG∅, TumMeta↓, Ki-67↓, Gli1↓, HH↓,
1168- IVM,  SRF,    Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways
- in-vitro, HCC, NA
TumMeta↓, mTOR↓, EMT↓, CSCsMark↓, STAT3↓,
8037- IVM,    Ivermectin inhibits tumor metastasis by regulating the Wnt/β-catenin/integrin β1/FAK signaling pathway
- in-vitro, Var, NA
Wnt↓, β-catenin/ZEB1↓, ITGB1↓, FAK↓, TumCMig↓, TumMeta↓, GSK‐3β↓, other↝,
8028- IVM,    Ivermectin as an Alternative Anticancer Agent: A Review of Its Chemical Properties and Therapeutic Potential
- Review, Var, NA
*BioAv↝, Apoptosis↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, TumPF↓, CSCs↓, eff↑, ChemoSen↑, mtDam↑, MMP↓, ATP↓, ROS↑, NF-kB↓, BAX↑, Casp3↑, Casp9↑, ICD↑, Ki-67↓, PSA↓, YAP/TEAD↓,
8043- IVM,    Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma
- vitro+vivo, ESCC, KYSE-30 - in-vitro, ESCC, KYSE70 - in-vitro, ESCC, KYSE150
tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, PAK1↓, ChemoSen↑, cl‑PARP↑, Casp3↑, TumMeta↓,
7896- IVT,  VT,    Molecular targets of vitexin and isovitexin in cancer therapy: a critical review
- Review, Var, NA
chemoPv↑, Dose↝, ACE/ACE1↓, Ca+2↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Stroke↓, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, TumAuto↑, HSP90↑, ER Stress↑, Hif1a↓, TumMeta↓, angioG↓, Tf↓, MAPK↓, PI3K↓, Akt↓, β-catenin/ZEB1↓, TumCCA↑, FOXO3↓, mTOR↓,
7961- JG,    Juglone Inhibits Tumor Metastasis by Regulating Stemness Characteristics and the Epithelial-to-Mesenchymal Transition in Cancer Cells both in Vitro and in Vivo
- vitro+vivo, BC, MCF7 - in-vitro, BC, 4T1 - vitro+vivo, CRC, HCT116
EMT↓, CSCs↓, TumMeta↓, Pin1↓, TumCCA↑, angioG↓, Apoptosis↑, BAX↑, Bcl-2↓,
7965- JG,    Mechanistic investigation of Juglone (5-hydroxy-1,4-naphthoquinone) as an anti-cancer agent in human colorectal cancer HCT116 and HT-29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
Apoptosis↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Bcl-2↓, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, ERK↓, AKT1↓, p38↑, JNK↑, TumCMig↓, TumCI↓, TumMeta↓,
8087- KAE,    Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways
- Review, Var, NA
TumCCA↓, ROS↝, Apoptosis↑, TumCP↑, TumMeta↓, angioG↓, PI3K↓, EMT↓, Snail↓, E-cadherin↓, N-cadherin↓, MMP2↓, Casp9↑, Casp7↑, PARP↑, Apoptosis↑, *ROS↓, Hif1a↓, p‑Akt↓, P53↑, cMyc↓, Glycolysis↓, PKM2↓, miR-339-5p↝, BioAv↓,
8089- KAE,    Kaempferol impairs aerobic glycolysis against melanoma metastasis via inhibiting the mitochondrial binding of HK2 and VDAC1
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, B16-F10
TumCMig↓, TumCI↓, TumMeta↓, ECAR↓, GlucoseCon↓, ATP↓, Pyruv↓, lactateProd↓, HK2↓, VDAC1↓, Akt↓, GSK‐3β↝, Glycolysis↓,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8071- KAE,    Cellular reprogramming and signaling control by kaempferol in colorectal cancer
- Review, CRC, NA
*toxicity↓, Risk↓, MMPs↓, VEGF↓, VEGFR1↓, Wnt↓, β-catenin/ZEB1↑, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, *BioAv↓, TumCCA↑, Apoptosis↑, Hif1a↓, ROS↑, TumCMig↓, TumMeta↓, PKM2↓, Glycolysis↓, DNAdam↑, HO-1↑, Ferroptosis↑, eff↑, Dose↝, BioAv↑,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
8168- LapC,  VitK3,    Promotion or suppression of experimental metastasis of B16 melanoma cells after oral administration of lapachol
- in-vitro, Melanoma, B16-BL6
TumMeta↑, eff↑, TumMeta↓,
8176- Las,    In Vitro and In Vivo Anti-Cancer Activity of Lasiokaurin in a Triple-Negative Breast Cancer Model
- vitro+vivo, BC, NA
TumCCA↑, Apoptosis↑, DNAdam↑, TumMeta↓, PI3K↓, Akt↓, mTOR↓, STAT3↓, TumVol↓, toxicity↓,
8255- LCA,    Antitumor and antimetastatic effects of licochalcone A in mouse models
- in-vivo, Colon, NA
COX2/PTGS2↓, iNOS↓, NF-kB↓, AP-1↓, AntiTum↑, β-catenin/ZEB1↓, OS↑, TumMeta↓, MMP9↓,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
8267- LE,    Glycyrrhizin Attenuates the Process of Epithelial-to-Mesenchymal Transition by Modulating HMGB1 Initiated Novel Signaling Pathway in Prostate Cancer Cells
- in-vitro, Pca, DU145
HMGB1↓, TumMeta↓, EMT↓,
8277- LE,    Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights
- Review, Var, NA
*antiOx↑, *AntiTum↑, HMGB1↓, COX2/PTGS2↓, PGE2↓, TumCP↓, TumCCA↑, Synergy↑, MMP↓, p‑P53↑, BAX↑, cl‑PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, ROS↑, TumAuto↑, MMP9↓, TumMeta↓, PI3K↓, Akt↓, eff↑, *chemoP↑, *NRF2↑, *NF-kB↓,
8278- LE,    Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
- Review, Var, NA
*Ingr↝, *AntiCan↑, *AntiDiabetic↑, *AntiBio↑, *Inflam↓, *antiAll↑, *hepatoP↑, *cough?, *SoreThr?, *toxicity↝, *cardioP↑, *BioAv↝, *PGE2↓, *COX2/PTGS2↓, *AntiAg↑, *ROS↓, *NLRP3↓, *NF-kB↓, *AP-1↓, TumCCA↑, Apoptosis↑, TumMeta↑, *Dose↝, *Dose↝, Ingr↝, TumAuto↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, *cognitive↑, *BloodF↑, ChemoSen↑, ROS↓, *chemoP↑, ROS↑, tumCV↓, MMP↓, *AntiBio↑, *toxicity↝,
8141- LF,    Controversial role of lactoferrin in cancer: A narrative review
- Review, Var, NA
*AntiBio↑, *antiOx↑, *Inflam↓, *Imm↑, *AntiCan↑, TumMeta↑,
8292- lign,    Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives
- Review, Var, NA
*BioAv↝, chemoPv↑, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, *AntiDiabetic↑, *antiOx↑, *AntiCan↑, *Inflam↓, *cardioP↑, TumCCA↑, PSA↓, miR-106b↓, IGF-1↓, ERK↓, Akt↓, Bcl-2↓, p‑FAK↓, radioP↑, P-gp/ABCB1↓, ChemoSen↑, MMP↓, ROS↑, BioAv↓, *toxicity↓, chemoP↑,
8393- LT,    Progress, pharmacokinetics and future perspectives of luteolin modulating signaling pathways to exert anticancer effects: A review
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, EMT↓, Imm↝, ChemoSen↑, *Inflam↓, *COX2/PTGS2↓, *NF-kB↓, MMP2↓, MMP9↓, p‑Akt↓, p‑PI3K↓, IGF-2↓, IGF-1R↓, CXCL16↓, NOTCH1↓, HES1↓, VEGF↓, ROS↑,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
8371- LT,    Study on the regulatory mechanism of luteolin inhibiting WDR72 on the proliferation and metastasis of non small cell lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Nor, BEAS-2B
TumCP↓, TumCI↓, TumCMig↓, TumVol↓, p‑Akt↓, Apoptosis↓, EMT↓, Dose↝, Akt↓, WDR72↓, TumMeta↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2909- LT,    Revisiting luteolin: An updated review on its anticancer potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, TumCP↓, chemoP↑, MDR1↓,
8343- Lut,    Association of Lutein with Cancer: A Systematic Review of the Lutein Effects on Cellular Processes Involved in Cancer Progression
- Review, Var, NA
*antiOx↑, *Inflam↓, Risk↓, AntiCan∅, Apoptosis↑, ROS↓, NRF2↓, Akt↓, ERK↓, NF-kB↓, Bcl-2↓, BAX↑, Casp3↑, DNAdam↑, ROS↓, P53↑, PCNA↓, cycD1/CCND1↓, TumCP↓, Hif1a↓, NOTCH↓, miR-590-3p↑, TumCMig↓, TumCI↓, TumMeta↓, TumCA↓, *BioAv↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
8513- MAG,    Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I
- vitro+vivo, Oral, SCC4 - in-vitro, Tong, SCC9 - in-vitro, SCC, CAL27
TumCG↓, TumMeta↓, *toxicity↓, Ingr?, chemoPv↑, compI↓, mitResp↓, ETC↓, AMPK↑, STAT3↓, ox-PrxI↑, Dose↝, Ki-67↓, STAT3↓, P70S6K↓, HK2↓, survivin↓, BioAv↝, Half-Life↝, ROS↑,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
8566- Matr,    Matrine suppresses lung metastasis of human hepatocellular carcinoma by directly targeting matrix metalloproteinase-9
- vitro+vivo, HCC, MHCC-97H
TumCMig↓, TumCI↓, Dose↓, MMP9↓, TumMeta↓,
8569- Matr,    Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway
- vitro+vivo, Cerv, NA
TumCG↓, Apoptosis↑, TumCI↓, TumCMig↓, MMP2↓, MMP9↓, p38↓, TumCG↓, TumMeta↓,
8576- Matr,    Matrine reduces the proliferation and invasion of colorectal cancer cells via reducing the activity of p38 signaling pathway
- vitro+vivo, CRC, NA
TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑p38↓, TumMeta↓,
8626- MBZ,    The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells
- in-vitro, Lung, NA
mitA↑, Apoptosis↑, Casp↑, Cyt‑c↑, AntiTum↑, TumMeta↓, toxicity↓,
8643- MBZ,    Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, BC, SUM159
*toxicity↓, TumCP↓, Apoptosis↑, TumCCA↑, TumVol↓, TumMeta↓, ITGB4↓, CSCs↓, Dose↝, TumCMig↓,

Showing Research Papers: 201 to 250 of 371
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 371

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 16,   antiOx⇅, 1,   Catalase↑, 3,   Fenton↑, 2,   GPx↑, 3,   GPx1↓, 1,   GPx4↓, 5,   GSH↓, 20,   GSH↑, 4,   GSH/GSSG↓, 1,   GSR↓, 2,   GSR↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 3,   HO-1↑, 9,   Iron↑, 2,   lipid-P↓, 2,   lipid-P↑, 9,   MDA↓, 2,   MDA↑, 5,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 1,   NRF2↓, 12,   NRF2↑, 10,   NRF2↝, 1,   Prx↓, 2,   Prx4↑, 1,   ox-PrxI↑, 1,   PrxII↓, 1,   RNS↑, 1,   ROS↓, 17,   ROS↑, 140,   ROS⇅, 4,   ROS↝, 1,   i-ROS↓, 1,   mt-ROS↑, 2,   SOD↓, 1,   SOD↑, 6,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 3,   Thiols↓, 1,   Trx↓, 1,   TrxR↓, 6,   TrxR1↓, 1,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC25↓, 4,   compI↓, 1,   EGF↓, 1,   ETC↓, 5,   mitResp↓, 3,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↑, 9,   OCR↓, 5,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   PDH↝, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 2,   ACC↑, 1,   ALAT↓, 3,   AMPK?, 1,   AMPK↓, 1,   AMPK↑, 14,   p‑AMPK↑, 1,   ATP↓, 14,   ATP↑, 1,   mt-ATP↓, 1,   Buty↑, 1,   CAIX/CA9↑, 1,   ECAR↓, 3,   ENO1↓, 1,   FAO↓, 1,   FASN↓, 5,   G6PD↓, 3,   GAPDH↓, 1,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 12,   GlutMet↓, 1,   Glycolysis↓, 31,   GSK‐3β↓, 11,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   Histones↑, 1,   HK2↓, 13,   HMG-CoA↓, 1,   lactateProd↓, 10,   lactateProd↑, 1,   LDHA↓, 6,   LDL↓, 3,   NADPH↓, 3,   NADPH↑, 1,   PA↑, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 10,   PPP↓, 1,   Pyruv↓, 1,   SCD1↓, 1,   SCFAs↑, 1,   SIRT1↓, 5,   SIRT1↑, 8,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 7,   Apoptosis↑, 154,   m-Apoptosis↑, 1,   mt-Apoptosis↑, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 3,   BAD↑, 2,   Bak↑, 4,   BAX↓, 1,   BAX↑, 57,   Bax:Bcl2↑, 11,   Bcl-2↓, 65,   Bcl-2↑, 4,   Bcl-xL↓, 18,   BID↓, 1,   BID↑, 3,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 6,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 24,   Casp↝, 1,   Casp∅, 1,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 76,   cl‑Casp3↑, 7,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 13,   cl‑Casp7↑, 2,   Casp8↑, 11,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↑, 44,   cl‑Casp9↑, 3,   proCasp9↑, 1,   cFLIP↓, 2,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 46,   Cyt‑c↝, 1,   Diablo↑, 6,   DR5↑, 10,   Endon↑, 1,   FADD↑, 5,   Fas↓, 1,   Fas↑, 10,   FasL↑, 4,   Ferroptosis↑, 11,   GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 5,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 8,   Mcl-1↓, 14,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 6,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 1,   p38↓, 4,   p38↑, 11,   p‑p38↓, 3,   p‑p38↑, 2,   Paraptosis↑, 1,   PUMA↑, 2,   Pyro↑, 3,   survivin↓, 37,   TRAIL↑, 1,   TumCD↑, 14,   TumCD∅, 1,   XIAP↓, 13,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 111,   Akt↑, 1,   p‑Akt↓, 16,   p‑Akt↑, 1,   AKT1↓, 3,   Akt2↓, 1,   BRAF↓, 1,   CaMKII ↑, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   CREB↓, 1,   CREB↑, 1,   cSrc↓, 2,   DDIT4↑, 1,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 27,   p‑EGFR↓, 1,   ERK↓, 30,   ERK↑, 4,   ERK↝, 1,   p‑ERK↓, 8,   p‑ERK↑, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↝, 1,   IGF-1R↓, 4,   IGFR↓, 1,   IKKα↓, 5,   IP6K1↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 4,   JAK1↓, 3,   JAK2↓, 8,   JNK↓, 4,   JNK↑, 13,   p‑JNK↓, 3,   p‑JNK↑, 2,   MAPK?, 1,   MAPK↓, 34,   MAPK↑, 7,   MARK4↓, 1,   MEK↓, 3,   mTOR↓, 50,   mTOR↑, 1,   p‑mTOR↓, 3,   mTORC2↓, 1,   p42↑, 1,   P70S6K↓, 2,   PI3K↓, 78,   p‑PI3K↓, 2,   PKA↓, 1,   PKCδ↓, 7,   PTEN↓, 1,   PTEN↑, 17,   p‑PTEN↓, 1,   Raf↓, 2,   c-Raf↓, 1,   RAS↓, 6,   SHP1↑, 2,   Sp1/3/4↓, 10,   Src↓, 2,   STAT↓, 4,   STAT3↓, 51,   STAT3↑, 1,   STAT3↝, 1,   p‑STAT3↓, 7,   STAT5↓, 2,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↓, 1,   ATF4↑, 4,   ATF4↝, 1,   CBP↓, 3,   ChrMod↑, 1,   circNAV3↓, 1,   cJun↓, 3,   cJun↑, 2,   cMyc↓, 23,   cMyc↑, 1,   DNMT1↓, 5,   DNMT3A↓, 2,   DNMTs↓, 5,   EZH2↓, 2,   FOXM1↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   GATA2↑, 1,   H3↑, 1,   ac‑H3↑, 2,   H4↑, 2,   ac‑H4↑, 2,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 16,   HDAC1↓, 5,   HDAC2↓, 2,   HDAC4↓, 3,   HDAC8↓, 1,   HES1↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-125b↝, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 1,   miR-200b↑, 1,   miR-205↑, 1,   miR-21↓, 4,   miR-218↑, 1,   miR-224↓, 1,   miR-29b↑, 2,   miR-30a-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-422a↑, 1,   miR-590-3p↑, 1,   Myc↓, 4,   NDRG1↑, 2,   OCT4↓, 9,   other?, 3,   other↓, 1,   other↑, 8,   other↝, 12,   PCAF↓, 1,   SD↝, 1,   SOX2↓, 7,   SOX4↓, 1,   SOX4↑, 1,   TCF-4↓, 1,   TLE1↓, 1,   tumCV↓, 26,   tumCV∅, 1,   YMcells↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 11,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↓, 2,   ER Stress↑, 23,   GRP78/BiP↓, 2,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 3,   e-HSP70/HSPA5↓, 1,   HSP90↓, 8,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 2,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 3,   LC3B-II↑, 1,   LC3II↑, 10,   LC3s↓, 1,   LC3s↑, 1,   p62↓, 4,   p62↑, 1,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 34,   TumAuto↝, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 2,   BRCA1↑, 2,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 38,   DNArepair↓, 2,   DNArepair↑, 1,   m-FAM72A↓, 1,   G9a↓, 1,   hTERT/TERT↓, 5,   P53?, 1,   P53↓, 2,   P53↑, 59,   P53↝, 2,   p‑P53↑, 3,   PARP↑, 5,   cl‑PARP↓, 1,   cl‑PARP↑, 38,   PARP1↑, 3,   PCNA↓, 20,   POLD1↓, 1,   SIRT6↓, 1,   Telomerase↓, 5,   TOP1↓, 5,   TOP2↓, 4,   TP53↑, 1,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 5,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK2↓, 21,   CDK2↑, 1,   CDK4↓, 29,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 9,   CDK6↑, 1,   CDK7↓, 1,   CHK1↓, 2,   CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 2,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 12,   cycD1/CCND1↓, 47,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 11,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   Ki-67↓, 22,   Ki-67↑, 1,   MAD↓, 1,   mitA↑, 2,   P21?, 1,   P21↓, 3,   P21↑, 40,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 15,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   RRM2↓, 1,   Securin↓, 1,   TubPol↓, 1,   TumCCA?, 1,   TumCCA↓, 8,   TumCCA↑, 132,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 8,   ALDH1A1↓, 1,   AXIN1↑, 1,   Axin2↑, 1,   BMI1↓, 1,   BMPs↑, 2,   CD133↓, 5,   CD133↑, 1,   CD24↓, 3,   CD34↓, 2,   cFos↓, 5,   cMYB↓, 1,   CSCs↓, 35,   CSCsMark↓, 1,   Diff↑, 4,   Gli1↓, 7,   HH↓, 7,   HMGCR↓, 1,   IGF-1↓, 5,   IGF-2↓, 1,   IGFBP3↑, 2,   Jun↓, 1,   Ki-67↓, 22,   Ki-67↑, 1,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 7,   Nestin↓, 1,   NOTCH↓, 9,   NOTCH1↓, 9,   NOTCH1↑, 2,   NOTCH1↝, 1,   NOTCH3↓, 2,   p300↓, 3,   Piezo1↑, 1,   PTCH1↓, 1,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 3,   Smo↓, 2,   STAT1↓, 1,   TumCG?, 1,   TumCG↓, 86,   TumCG↑, 4,   TumCG⇅, 1,   TumCG↝, 1,   TumCG∅, 2,   TumCP↓, 133,   TumCP↑, 4,   WDR72↓, 1,   Wnt↓, 29,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 10,   AP-1↝, 1,   ASAP2↓, 1,   AXL↓, 2,   BACH1↑, 1,   Ca+2↓, 2,   Ca+2↑, 14,   CAFs/TAFs↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   Cdc42↑, 1,   COL11A1↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 45,   EMT↓, 80,   EMT↑, 2,   EpCAM↓, 3,   F-actin↓, 2,   FAK↓, 15,   p‑FAK↓, 4,   p‑FAK↑, 1,   Fibronectin↓, 4,   GIT1↓, 1,   GLI2↓, 1,   ITGB1↓, 4,   ITGB4↓, 2,   ITGB6↓, 1,   LAMs↓, 1,   LEF1↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP1↓, 5,   MMP13↓, 5,   MMP15↓, 1,   MMP16↓, 1,   MMP2↓, 76,   MMP3↓, 6,   MMP7↓, 4,   MMP9↓, 95,   MMP9↑, 3,   MMPs↓, 40,   MUC4↓, 2,   N-cadherin↓, 29,   Na+↑, 1,   NEDD9↓, 1,   p44↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 4,   Rac1↓, 2,   RECK↑, 2,   Rho↓, 7,   ROCK1↓, 4,   Slug↓, 14,   SMAD2↓, 3,   SMAD3↓, 4,   SMAD4↓, 2,   Snail?, 1,   Snail↓, 27,   TET1↑, 2,   TGF-β↓, 15,   TGF-β↑, 2,   TIMP1↑, 8,   TIMP2↑, 9,   TIMP3↑, 1,   pol-TregCell↓, 1,   TRIB3↑, 2,   TSP-1↑, 2,   TumCA↓, 1,   TumCI?, 1,   TumCI↓, 116,   TumCI↑, 3,   TumCMig↓, 64,   TumCMig↑, 2,   TumMeta?, 1,   TumMeta↓, 354,   TumMeta↑, 20,   TumMeta∅, 1,   TumPF↓, 1,   Twist↓, 18,   TXNIP↑, 1,   uPA↓, 12,   uPAR↓, 2,   Vim?, 1,   Vim↓, 34,   Vim↑, 1,   Zeb1↓, 15,   ZEB2↓, 3,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 40,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 125,   angioG↑, 5,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   ECM/TCF↓, 1,   eNOS↓, 1,   HIF-1↓, 5,   Hif1a↓, 41,   Hif1a↝, 1,   NO↓, 4,   TXA2↓, 2,   VCAM-1↓, 1,   VEGF↓, 76,   VEGFR1↓, 4,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 9,   CellMemb↑, 1,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN2↓, 1,   EPR↑, 9,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↑, 1,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 59,   MPT↑, 2,   Na+↑, 1,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPM7↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 11,   CD8+↑, 6,   COX1↓, 5,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 1,   CXCL12↓, 1,   CXCL16↓, 1,   CXCR2↓, 2,   CXCR4↓, 13,   DCells↑, 1,   DR4↑, 5,   FOXP3↓, 1,   Gal-3↓, 2,   HMGB1↓, 2,   ICAM-1↓, 6,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 4,   IL1↑, 1,   IL10↓, 3,   IL10↑, 1,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL6↓, 33,   IL6↑, 1,   IL8↓, 9,   IL8↑, 1,   Imm↑, 23,   Imm↝, 3,   Inflam↓, 30,   Inflam↝, 1,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   mPGES-1↓, 1,   NF-kB?, 1,   NF-kB↓, 100,   NF-kB↑, 2,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 7,   NLRP3↓, 5,   NLRP3↑, 1,   p65↓, 4,   p‑p65↓, 2,   PD-1↓, 2,   PD-L1↓, 3,   PGE2↓, 14,   PSA↓, 6,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 1,   TCF7/TCF1↓, 1,   Th1 response↑, 2,   TLR4↓, 2,   TLR4↝, 1,   TNF-α↓, 20,   TNF-α↑, 4,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   e-pH↑, 5,   TAMS↑, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 7,   ERα/ESR1↓, 1,   FGF21↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 38,   BioAv↑, 40,   BioAv↝, 8,   BioEnh↑, 2,   ChemoSen?, 1,   ChemoSen↓, 2,   ChemoSen↑, 119,   ChemoSen∅, 1,   CompStab?, 1,   CompStab↓, 3,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 4,   Dose?, 2,   Dose↓, 2,   Dose↑, 3,   Dose↝, 37,   Dose∅, 6,   DrugR↓, 1,   eff↓, 15,   eff↑, 73,   eff↝, 4,   eff∅, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 12,   Half-Life↑, 3,   Half-Life↝, 8,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 14,   P-gp/ABCB1↑, 1,   P-gp/ABCB1↝, 1,   P450↓, 2,   RadioS?, 1,   RadioS↑, 27,   selectivity?, 1,   selectivity↑, 45,   Synergy↑, 63,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 3,   ALP↓, 1,   AR↓, 7,   ascitic↓, 1,   AST↓, 2,   BP↓, 1,   BRAF↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   p‑BRCA1↑, 1,   CRP↓, 1,   CTC↓, 1,   EGFR↓, 27,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 2,   FOXM1↓, 2,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 5,   IL6↓, 33,   IL6↑, 1,   LDH↓, 2,   LDH↑, 2,   e-LDH↑, 1,   Maspin↑, 1,   Myc↓, 4,   NOS2↓, 1,   PD-L1↓, 3,   PSA↓, 6,   PSADT↓, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 2,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 39,   AntiCan∅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 2,   AntiTum↑, 27,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 21,   chemoPv↑, 20,   ChemoSideEff↓, 3,   fatigue↓, 1,   FTO↓, 1,   hepatoP↓, 1,   hepatoP↑, 6,   kidSt↓, 1,   neuroP↑, 7,   OS↑, 20,   OS⇅, 1,   Pain↓, 3,   Pin1↓, 1,   QoL↑, 8,   radioP↑, 11,   Remission↑, 3,   RenoP↑, 3,   Risk↓, 21,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 14,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 26,   TumVol∅, 1,   TumW↓, 7,   TumW∅, 1,   Weight↓, 1,   Weight↑, 2,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 2,   GutMicro↑, 6,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 2,   Ingr↝, 3,  
Total Targets: 883

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 50,   Catalase↑, 19,   GPx↑, 16,   GPx1↑, 2,   GSH↑, 12,   GSR↑, 4,   GSTs↑, 10,   H2O2↓, 1,   HDL↓, 1,   HO-1↑, 10,   Iron∅, 1,   Keap1↓, 1,   lipid-P↓, 18,   MDA↓, 6,   NRF2↑, 19,   RNS↓, 1,   ROS?, 2,   ROS↓, 50,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 19,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 1,   VitC↑, 1,   VitE↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↓, 1,   AMPK↑, 4,   ATP↓, 1,   cytoP450↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   LDL↓, 2,   lipidLev↓, 2,   NAD↓, 1,   NADPH↑, 1,   SIRT1↑, 2,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↓, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 7,   p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt2↓, 1,   CREB↑, 1,   ERK↑, 1,   IKKα↓, 1,   p‑JNK↓, 1,   MAPK↓, 3,   mTOR↓, 1,   PI3K↓, 1,   PKCδ↓, 2,   STAT↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   other↓, 2,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   GADD34↓, 1,   P21↓, 2,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,   TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 7,   AP-1↓, 2,   Ca+2↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 1,   MMP9↓, 1,   TGF-β↓, 1,   TumMeta↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 5,   TXA2↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   GastroP↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   MMP↓, 1,   MMP↑, 1,   MMP∅, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 13,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL17↓, 2,   IL1β↓, 8,   IL2↓, 1,   IL23↓, 1,   IL6?, 1,   IL6↓, 10,   Imm↓, 1,   Imm↑, 5,   Imm⇅, 1,   Inflam?, 1,   Inflam↓, 53,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB?, 1,   NF-kB↓, 15,   NLRP3↓, 3,   PGE2↓, 6,   TLR4↓, 1,   TLR4↑, 1,   TNF-α?, 1,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 6,   AChE↝, 1,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 2,   MAOA↓, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   Estro↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 17,   BioAv↑, 23,   BioAv↝, 6,   BioEnh↑, 1,   CompStab↑, 2,   Dose?, 1,   Dose↝, 4,   eff↑, 3,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↝, 2,   Half-Life∅, 1,   P450↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 3,   AST↓, 4,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 1,   CRP↓, 4,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 10,   IRes↑, 1,   LDH↓, 2,   TC↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 4,   antiAll↑, 2,   AntiArt↑, 4,   AntiCan↑, 11,   AntiDiabetic↑, 12,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP↑, 23,   chemoP↑, 4,   cognitive↓, 1,   cognitive↑, 7,   cough?, 1,   hepatoP↑, 18,   memory↑, 8,   Mood↑, 1,   motorD↓, 1,   neuroP↑, 32,   Obesity↓, 4,   OS↑, 1,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   SoreThr?, 1,   Stroke↓, 1,   toxicity↓, 19,   toxicity↑, 1,   toxicity↝, 6,   toxicity∅, 4,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↑, 3,   AntiP↑, 1,   AntiViral↑, 6,   Bacteria↓, 8,   GutMicro↑, 9,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↑, 3,   Ingr↝, 8,   Phen↑, 1,   QC↑, 1,  
Total Targets: 224

Scientific Paper Hit Count for: TumMeta, Cancer Metastasis
15 Curcumin
11 Thymoquinone
9 Nimbolide
8 Resveratrol
8 Eugenol
8 Quercetin
7 Melatonin
7 Pterostilbene
6 Chrysin
6 Magnetic Fields
6 Bicarbonate(Sodium)
5 Artemisinin
5 Aspirin
5 chitosan
5 Fisetin
5 Fucoidan
5 Gambogic Acid
5 Honokiol
5 phytic acid, Inositol hexakisphosphate
5 Kaempferol
5 Luteolin
5 Phenethyl isothiocyanate
4 Silver-NanoParticles
4 brusatol
4 Capsaicin
4 Celastrol
4 Flaxseed/Linseed
4 Inositol
4 Ivermectin
4 Magnetic Field Rotating
4 Marjoram (Origanum majorana)
4 Piperlongumine
4 Sulforaphane (mainly Broccoli)
4 Silymarin (Milk Thistle) silibinin
3 Baicalein
3 Berbamine
3 Biochanin A
3 Beta-Caryophyllene
3 Propolis -bee glue
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Chlorogenic acid
3 Cinnamon
3 Copper and Cu NanoParticles
3 Disulfiram
3 immunotherapy
3 EGCG (Epigallocatechin Gallate)
3 Garcinol
3 Ginkgetin
3 Licorice
3 Matrine
3 mebendazole
3 Modified Citrus Pectin
3 Ursolic acid
3 Vitamin C (Ascorbic Acid)
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Isovitexin
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Astaxanthin
2 Betulinic acid
2 Brucea javanica
2 Bromelain
2 Boswellia (frankincense)
2 Bruteridin(bergamot juice)
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Zinc
2 Coenzyme Q10
2 Vitamin K2
2 Cucurbitacin
2 Cyclopamine
2 Deguelin
2 D-limonene
2 Ellagic acid
2 Emodin
2 Sorafenib (brand name Nexavar)
2 Formononetin
2 Gallic acid
2 Ginkgo biloba
2 Isoliquiritigenin
2 isoorientin
2 Juglone
2 Licochalcone A
2 Lycopene
2 Magnolol
2 Radiotherapy/Radiation
2 Rosmarinic acid
2 Selenium
2 Selenium NanoParticles
2 Urolithin
1 1,8-Cineole
1 3-bromopyruvate
1 Astragalus
1 Ajoene (compound of Garlic)
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 almonertinib
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Atorvastatin
1 beta-glucans
1 Berberine
1 Bufalin/Huachansu
1 borneol
1 Butyrate
1 Carnosic acid
1 Caffeic acid
1 urea
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Docetaxel
1 Chocolate
1 Metformin
1 Boron
1 Carica papaya leaf extract
1 Crocetin
1 Dasatinib/Phyrago
1 Diclofenac
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 Dipyridamole
1 Ginkgo biloba-EGb 761
1 Electrical Pulses
1 Ferulic acid
1 ferumoxytol
1 Flaxseed Oil
1 Shilajit/Fulvic Acid
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Inulin Prebiotic
1 capecitabine
1 Gemcitabine (Gemzar)
1 isoflavones
1 isoquercitrin
1 itraconazole
1 Vitexin
1 Lapachol
1 VitK3,menadione
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Lutein
1 MCT oil
1 Magnesium
1 Moringa oleifera
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Dichloroacetate
1 Oleuropein
1 Aromatherapy
1 Phenylbutyrate
1 Piperine
1 Sanguinarine
1 Psoralidin
1 salinomycin
1 Sulfasalazine
1 Shikonin
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Whole Body Vibration
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:604  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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