TumMeta Cancer Research Results

TumMeta, Cancer Metastasis: Click to Expand ⟱
Source:
Type:
Cancer metastasis is the process by which cancer cells spread from the original (primary) tumor to other parts of the body, forming new (secondary) tumors. This occurs when cancer cells invade surrounding tissues, enter the bloodstream or lymphatic system, and travel to distant organs or tissues.


Scientific Papers found: Click to Expand⟱
7748- ISL,  GEM,    Isoliquiritigenin combined with gemcitabine inhibited lung cancer by suppressing JAK2/STAT3 signaling via lncRNA-p21/miRNA-4534 axis
- NA, Lung, NA
Dose↝, Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, P21↑, selectivity↑, JAK2↓, STAT3↓,
7762- ISL,    Isoliquiritigenin reduces brain metastasis by circNAV3-ST6GALNAC5-EGFR axis in triple-negative breast cancer
- in-vivo, BC, NA
TumMeta↓, circNAV3↓,
7735- isoFl,    Soy Isoflavones in Integrative Oncology: Increased Efficacy and Decreased Toxicity of Cancer Therapy
- Review, Var, NA
Risk↓, ChemoSen↑, chemoP↑, RadioS↑, radioP↑, NF-kB↓, DNMTs↓, TumMeta↓, angioG↓, antiOx↑, BioAv↑, toxicity↓,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
7853- isoO,    Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review
- Review, Var, NA
Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,
7796- ISQ,    Isoquercitrin restrains the proliferation and promotes apoptosis of human osteosarcoma cells by inhibiting the Wnt/β-catenin pathway
- vitro+vivo, OS, 143B - in-vitro, OS, U2OS
TumCP↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, Apoptosis↑, TumMeta↓, TumCCA↑, BAX↑, cl‑Casp3↑, Bcl-2↓,
1168- IVM,  SRF,    Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways
- in-vitro, HCC, NA
TumMeta↓, mTOR↓, EMT↓, CSCsMark↓, STAT3↓,
7896- IVT,  VT,    Molecular targets of vitexin and isovitexin in cancer therapy: a critical review
- Review, Var, NA
chemoPv↑, Dose↝, ACE/ACE1↓, Ca+2↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Stroke↓, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, TumAuto↑, HSP90↑, ER Stress↑, Hif1a↓, TumMeta↓, angioG↓, Tf↓, MAPK↓, PI3K↓, Akt↓, β-catenin/ZEB1↓, TumCCA↑, FOXO3↓, mTOR↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2909- LT,    Revisiting luteolin: An updated review on its anticancer potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, TumCP↓, chemoP↑, MDR1↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, eff↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, eff↑,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
1779- MEL,    Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review
- Review, BC, NA
QoL↑, OS↑, Dose∅, antiOx↑, ROS↑, SOD↑, Catalase↑, GPx↑, Risk↓, NK cell↑, IL1β↓, IL6↓, TNF-α↓, radioP↑, chemoP↑, TumVol↓, TumMeta↓, angioG↓, ChemoSen↑, eff↑,
517- MF,  Rad,    Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasis
- in-vivo, NA, MDA-MB-231
TumMeta↓, TumCG↓,
3500- MF,    Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS-Mediated Oxidative Stress
- in-vitro, Ovarian, SKOV3
ROS↑, CSCs↓, CD44↓, SOX2↓, cMyc↓, TumMeta↓, TumCI↓, TumCMig↓, CD133↓, Nanog↓,
3464- MF,    Progressive Study on the Non-thermal Effects of Magnetic Field Therapy in Oncology
- Review, Var, NA
AntiTum↑, TumCG↓, TumCCA↑, Apoptosis↑, TumAuto↑, Diff↑, angioG↓, TumMeta↓, EPR↑, ChemoSen↑, ROS↑, DNAdam↑, P53↑, Akt↓, MAPK↑, Casp9↑, VEGFR2/KDR/Flk1↓, P-gp/ABCB1↓,
205- MFrot,  MF,    Intermittent F-actin Perturbations by Magnetic Fields Inhibit Breast Cancer Metastasis
- vitro+vivo, BC, MDA-MB-231
OS↑, F-actin↓, TumCI↓, TumCMig↓, Rho↓, selectivity↑, TumMeta↓,
200- MFrot,  MF,    Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice
- in-vivo, BC, MDA-MB-231 - in-vivo, BC, MCF7
ALAT↓, TumVol↓, TumCCA↑, TumCG↓, TumMeta↓, Imm↑, P53↑, ALAT↓, AST↓,
198- MFrot,  MF,    Biological effects of rotating magnetic field: A review from 1969 to 2021
- Review, Var, NA
AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,
5242- MFrot,    Rotating magnetic field downregulating type XI collagen to suppress triple-negative breast cancer metastasis by inactivating the ITGB1/FAK/YAP signaling pathway
- in-vitro, BC, NA
TumCI↓, COL11A1↓, TumCG↓, TumMeta↓, ITGB1↓, FAK↓, YAP/TEAD↓, Dose↝,
2938- NAD,    NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling
- in-vivo, BC, NA
TumMeta↓, SIRT1↑,
5598- NaHCO3,    Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
- in-vivo, BC, MDA-MB-231
e-pH↑, TumMeta↓, TumCG⇅, Dose↑,
5616- NaHCO3,  DCA,    Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer
- vitro+vivo, BC, MDA-MB-231
OS↑, e-pH↑, TumMeta↓, eff↝, TumCG↝,
5612- NaHCO3,  immuno,    Neutralization of tumor acidity improves anti-tumor responses to immunotherapies
- vitro+vivo, Var, B16-F10
Imm↑, eff↑, e-pH↑, TumCG↓, TumMeta↓, eff↑,
5608- NaHCO3,    Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism
- Study, Var, NA
TumCG↓, TumMeta↓, e-pH↑, Pyro↑, Imm↑, Na+↑,
5607- NaHCO3,    Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review
- Review, Var, NA
AntiCan↑, e-pH↑, TumMeta↓, TumCI↓, TumCG↓, CD8+↑, NK cell↑, Remission↑, eff↑, ChemoSen↑, ChemoSen↓,
5604- NaHCO3,    Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity
- vitro+vivo, Melanoma, B16-BL6 - in-vitro, BC, 4T1
eff↑, eff↑, TumMeta↓, pH↑, CaMKII ↑, CREB↑, PGC-1α↑, AntiTum↑, Imm↑, CD8+↑, TAMS↑,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
6489- Nimb,    Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model
- in-vivo, Pca, DU145 - in-vivo, Pca, LNCaP
tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, STAT3↓, ROS↑, TumCG↓, TumMeta↓, TumCCA↑, DNAdam↑, Casp3↑, Casp7↑, cl‑PARP↑, p‑STAT3↓, IL6↓, GSR↓,
6488- Nimb,    Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation
- in-vitro, BC, NA
TumCP↓, AntiTum↑, TumMeta↓, selectivity↑,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4970- Nimb,    Insights into Nimbolide molecular crosstalk and its anticancer properties
- Review, Var, NA
chemoPv↑, Apoptosis↑, TumCP↓, TumCD↑, TumMeta↓, angioG↓,
4971- Nimb,    Nimbolide, a Neem Limonoid, Is a Promising Candidate for the Anticancer Drug Arsenal
- Review, Var, NA
TumCP↓, Apoptosis↓, TumCI↓, angioG↓, TumMeta↓, Inflam↓,
4974- Nimb,    Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma
- in-vitro, OS, NA
Apoptosis↑, ER Stress↑, mtDam↑, ROS↑, Casp↑, TumCMig↓, TumMeta↓,
4977- Nimb,    Nimbolide Inhibits SOD2 to Control Pancreatic Ductal Adenocarcinoma Growth and Metastasis
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, PANC1
SOD2↑, TumCG↓, TumMeta↓, ROS↑, Apoptosis↑, PI3K↓, Akt↓, EMT↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, Bcl-2↓,
4628- OLE,    Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases
- in-vitro, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumCI↓, TumMeta↓,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP/DDIT3↑, AR↓, other?,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, eff↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4918- PEITC,    Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
- Review, Var, NA
Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2/PTGS2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,
4932- PEITC,    Pharmacokinetics and Pharmacodynamics of Phenethyl Isothiocyanate: Implications in Breast Cancer Prevention
- Review, BC, NA
TumCCA↑, ROS↑, GSH↓, ERα/ESR1↓, TumMeta↓, angioG↓,
4933- PEITC,    Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification
- vitro+vivo, Lung, H1299 - vitro+vivo, SCC, H226
AntiCan↓, TumCP↓, TumMeta↓, ChemoSen↑, tumCV↓, TumCI↓, TumCMig↓, FTO↓, TLE1↓, Akt↓, NF-kB↓,
5187- PEITC,    Phenethyl Isothiocyanate Inhibits Migration and Invasion of Human Gastric Cancer AGS Cells through Suppressing MAPK and NF-κB Signal Pathways
- in-vitro, GC, AGS
TumMeta↓, ERK↓, MKK7↓, PKCδ↓, Rho↓, uPA↓, MMP2↓, MMP9↓, RAS↓, VEGF↓, FAK↓, iNOS↓, COX2/PTGS2↓, TumCP↓,
5209- PI,    Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP-9 signaling pathway in DU145 cells
- in-vitro, Pca, DU145
TumCP↓, TumCMig↓, Apoptosis↑, p‑Akt↓, MMP9↓, p‑mTOR↓, TumMeta↓, *antiOx↓, *Inflam↓, *hepatoP↑, *Imm↑, *AntiCan↑,
1945- PL,  SANG,    The Synergistic Effect of Piperlongumine and Sanguinarine on the Non-Small Lung Cancer
- in-vitro, Lung, A549
toxicity∅, Apoptosis↑, TumMeta↓, ROS↑, TumCCA↑,
2973- PL,    The Natural Alkaloid Piperlongumine Inhibits Metastatic Activity and Epithelial-to-Mesenchymal Transition of Triple-Negative Mammary Carcinoma Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1
MMP2↓, MMP9↓, IL6↓, E-cadherin↑, ROS↑, EMT↓, Zeb1↓, Slug↓, TumMeta↓, selectivity↑, MMP2↓, GSH↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,

Showing Research Papers: 201 to 250 of 317
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 317

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1,   circNAV3↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   antiOx⇅, 1,   Catalase↑, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   GPx↑, 3,   GSH↓, 5,   GSH↑, 1,   GSR↓, 1,   GSR↑, 1,   GSTA1↑, 1,   HO-1↑, 1,   lipid-P↑, 2,   MDA↑, 1,   NRF2↑, 1,   Prx4↑, 1,   ROS↓, 1,   ROS↑, 19,   SOD↑, 2,   SOD2↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   ETC↓, 1,   MKK7↓, 1,   MMP↓, 5,   mtDam↑, 2,   OCR↓, 1,   PGC-1α↑, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK?, 1,   CAIX↑, 1,   cMyc↓, 3,   CREB↑, 1,   CYP3A4↓, 1,   FASN↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   LDL↓, 1,   PPARγ↑, 2,   SIRT1↑, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 15,   p‑Akt↓, 3,   Apoptosis↓, 2,   Apoptosis↑, 22,   ASK1↑, 1,   BAX↓, 1,   BAX↑, 9,   Bax:Bcl2↑, 2,   Bcl-2↓, 9,   Bcl-2↑, 1,   Bcl-xL↓, 2,   BID↑, 1,   Casp↑, 3,   cl‑Casp↑, 1,   Casp3↑, 12,   cl‑Casp3↑, 2,   Casp7↑, 2,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 7,   Chk2↓, 1,   Cyt‑c↑, 7,   Cyt‑c↝, 1,   Diablo↑, 1,   DR4↑, 4,   DR5↑, 3,   FADD↑, 1,   Fas↑, 2,   FasL↑, 1,   iNOS↓, 1,   JNK↓, 1,   JNK↑, 3,   MAPK?, 1,   MAPK↓, 5,   MAPK↑, 2,   Mcl-1↓, 4,   MOMP↑, 1,   p27/CDKN1B↑, 4,   p‑p38↑, 1,   Pyro↑, 1,   survivin↓, 5,   Telomerase↓, 2,   TumCD↑, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↑, 1,   HER2/EBBR2↓, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

BowelM↑, 1,   ChrMod↑, 1,   other?, 1,   other↝, 1,   TLE1↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   ER Stress↓, 1,   ER Stress↑, 4,   GRP78/BiP↓, 1,   HSP27↑, 1,   HSP90↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↓, 1,   DNAdam↓, 1,   DNAdam↑, 4,   DNArepair↓, 1,   DNArepair↑, 1,   DNMTs↓, 1,   P53↓, 1,   P53↑, 9,   cl‑PARP↑, 6,   PCNA↓, 2,   γH2AX↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 7,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 6,   CycD3↓, 1,   cycE/CCNE↓, 3,   P21↑, 10,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 21,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CD44↓, 1,   CSCs↓, 1,   CSCsMark↓, 1,   Diff↑, 1,   EMT↓, 5,   ERK↓, 5,   ERK↑, 1,   p‑ERK↑, 1,   FOXO3↓, 2,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   HDAC↓, 2,   HH↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   IGFBP3↑, 1,   mTOR↓, 6,   p‑mTOR↓, 1,   Nanog↓, 1,   PI3K↓, 9,   PTEN↓, 1,   PTEN↑, 4,   p‑PTEN↓, 1,   RAS↓, 2,   SOX2↓, 1,   STAT1↓, 1,   STAT3↓, 9,   p‑STAT3↓, 1,   STAT6↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 10,   TumCG↑, 1,   TumCG⇅, 1,   TumCG↝, 1,   Wnt↓, 7,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   Ca+2↓, 1,   Ca+2↑, 1,   COL11A1↓, 1,   E-cadherin↑, 2,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↑, 1,   FTO↓, 1,   ITGB1↓, 2,   ITGB6↓, 1,   Ki-67↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 9,   MMP9↓, 11,   MMP9↑, 1,   MMPs↓, 3,   Na+↑, 1,   PDGF↓, 2,   PKCδ↓, 3,   Rho↓, 2,   Slug↓, 1,   SOX4↑, 1,   TIMP2↑, 1,   Treg lymp↓, 1,   TumCI↓, 14,   TumCMig↓, 8,   TumCP↓, 23,   TumMeta↓, 48,   TumMeta↑, 3,   Twist↓, 2,   uPA↓, 2,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 22,   ATF4↝, 1,   EGFR↓, 3,   EPR↑, 1,   Hif1a↓, 5,   NO↓, 1,   TAMS↑, 1,   VEGF↓, 7,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↑, 1,   GLUT3↑, 1,   Na+↑, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2,   COX2/PTGS2↓, 8,   CXCR2↓, 2,   CXCR4↓, 3,   DCells↑, 1,   FOXP3↓, 1,   ICAM-1↓, 2,   IKKα↓, 1,   IL1↑, 1,   IL10↑, 1,   IL1β↓, 1,   IL2↑, 2,   IL4↑, 1,   IL6↓, 7,   IL8↓, 1,   Imm↑, 5,   Inflam↓, 2,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 2,   NF-kB?, 1,   NF-kB↓, 16,   NK cell↑, 3,   p65↓, 1,   PGE2↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TNF-α↓, 3,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   e-pH↑, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 2,   ERα/ESR1↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 3,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 14,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 7,   Dose∅, 2,   eff↑, 16,   eff↝, 1,   eff∅, 1,   Half-Life↓, 1,   Half-Life↝, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P450↓, 2,   RadioS↑, 3,   selectivity↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AR↓, 1,   AST↓, 2,   EGFR↓, 3,   ERα/ESR1↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 7,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 7,   AntiTum↑, 3,   Appetite↑, 1,   breath↑, 1,   chemoP↑, 6,   chemoPv↑, 5,   ChemoSideEff↓, 2,   hepatoP↑, 1,   OS↑, 4,   OS⇅, 1,   Pain↓, 2,   QoL↑, 2,   radioP↑, 4,   Remission↑, 1,   Risk↓, 3,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 2,   toxicity∅, 1,   TumVol↓, 2,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 3,  
Total Targets: 309

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 5,   Catalase↑, 3,   GPx↑, 2,   GPx1↑, 1,   GSH↑, 2,   GSR↑, 1,   GSTA1↑, 1,   HDL↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 2,   ROS?, 1,   ROS↓, 4,   SOD↑, 2,   SOD1↑, 2,   SOD2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,   mTOR↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   MMP9↓, 1,   β-Endo↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IFN-γ↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL23↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 4,   MCP1/CCL2↓, 1,   NF-kB↓, 1,   TLR4↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   Dose↝, 2,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   hepatoP↑, 2,   neuroP↑, 1,   OS↑, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,  
Total Targets: 69

Scientific Paper Hit Count for: TumMeta, Cancer Metastasis
15 Curcumin
11 Thymoquinone
9 Nimbolide
8 Resveratrol
8 Eugenol
8 Quercetin
7 Pterostilbene
6 Chrysin
6 Magnetic Fields
6 Bicarbonate(Sodium)
5 Artemisinin
5 Aspirin
5 chitosan
5 Fisetin
5 Fucoidan
5 Gambogic Acid
5 Honokiol
5 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
5 Phenethyl isothiocyanate
4 brusatol
4 Capsaicin
4 Celastrol
4 Inositol
4 Magnetic Field Rotating
4 Piperlongumine
4 Sulforaphane (mainly Broccoli)
4 Silymarin (Milk Thistle) silibinin
3 Silver-NanoParticles
3 Melatonin
3 Baicalein
3 Berbamine
3 Biochanin A
3 Beta-Caryophyllene
3 Propolis -bee glue
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Chlorogenic acid
3 Cinnamon
3 Copper and Cu NanoParticles
3 Disulfiram
3 immunotherapy
3 EGCG (Epigallocatechin Gallate)
3 Garcinol
3 Ginkgetin
3 Ursolic acid
3 Vitamin C (Ascorbic Acid)
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Isovitexin
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Astaxanthin
2 Betulinic acid
2 Brucea javanica
2 Bromelain
2 Boswellia (frankincense)
2 Bruteridin(bergamot juice)
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Zinc
2 Coenzyme Q10
2 Vitamin K2
2 Cucurbitacin
2 Cyclopamine
2 Deguelin
2 D-limonene
2 Ellagic acid
2 Emodin
2 Sorafenib (brand name Nexavar)
2 Formononetin
2 Gallic acid
2 Ginkgo biloba
2 Isoliquiritigenin
2 isoorientin
2 Luteolin
2 Lycopene
2 Radiotherapy/Radiation
2 Rosmarinic acid
2 Selenium
2 Selenium NanoParticles
2 Urolithin
1 1,8-Cineole
1 3-bromopyruvate
1 Astragalus
1 Ajoene (compound of Garlic)
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 almonertinib
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Atorvastatin
1 beta-glucans
1 Berberine
1 Bufalin/Huachansu
1 borneol
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 urea
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Docetaxel
1 Chocolate
1 Metformin
1 Boron
1 Carica papaya leaf extract
1 Crocetin
1 Dasatinib/Phyrago
1 Diclofenac
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 Dipyridamole
1 Ginkgo biloba-EGb 761
1 Electrical Pulses
1 Ferulic acid
1 ferumoxytol
1 Shilajit/Fulvic Acid
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Inulin Prebiotic
1 capecitabine
1 Gemcitabine (Gemzar)
1 isoflavones
1 isoquercitrin
1 Ivermectin
1 Vitexin
1 Magnolol
1 nicotinamide adenine dinucleotide
1 Dichloroacetate
1 Oleuropein
1 Phenylbutyrate
1 Piperine
1 Sanguinarine
1 Psoralidin
1 salinomycin
1 Sulfasalazine
1 Shikonin
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Whole Body Vibration
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:604  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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