TumCD Cancer Research Results

TumCD, Tumor Cell Death: Click to Expand ⟱

Source:

Type:

Tumor Cell Death

Scientific Papers found: Click to Expand⟱

3381-

QC,

Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase

-

in-vitro,

Cerv,

HeLa

SREBP1/SREBF1↓, TumCP↓, TumCD↑, AMPK↑, SREBP1/SREBF1↓, FASN↓, ACC↓,

3378-

QC,

CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia

-

in-vitro,

AML,

NA

CK2↓, PI3K↓, TumCD↑, Akt↓, Mcl-1↓, PTEN↑,

73-

QC,

The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90

-

in-vitro,

Pca,

LNCaP

5, 10, 25, 50, 100 uM

 Normal prostate epithelial cells

-

in-vitro,

Pca,

DU145

-

in-vitro,

Pca,

PC3

HSP90↓, Casp3↑, Casp9↑, TumCG↓, TumCD↑, selectivity↑, toxicity↓,

93-

QC,

Chemical Proteomics Identifies Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A1 as the Molecular Target of Quercetin in Its Anti-cancer Effects in PC-3 Cells

-

in-vitro,

Pca,

PC3

 30 nM: 25, 50, 75, 100 uM

hnRNPA1↓, Casp3↑, Casp7↑, TumCD↑, IAP1↓,

884-

RES,

PTS,

Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells

-

in-vitro,

Cerv,

HeLa

pterostilbene displayed a 1.97-fold lower IC50 when compared to resveratrol (42.3 µM vs. 83.5 µM

TumCD↑, TumCCA↑, E6↓, Casp3↑, P53↑,

3017-

RosA,

Per,

Molecular Mechanism of Antioxidant and Anti-Inflammatory Effects of Omega-3 Fatty Acids in Perilla Seed Oil and Rosmarinic Acid Rich Fraction Extracted from Perilla Seed Meal on TNF-α Induced A549 Lung Adenocarcinoma Cells

-

in-vitro,

Lung,

A549

TumCD∅, ROS↓, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2/PTGS2↓, SOD2↓, FOXO1↓, NF-kB↓, JNK↓, antiOx↑, tumCV∅,

323-

Sal,

AgNPs,

Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy

-

in-vitro,

BC,

MDA-MB-231

 Sal (3 µM), AgNPs (4 µg/mL)

 IC25 values of both Sal and AgNPs (3.0 µM and 4 µg/mL)

-

in-vitro,

Ovarian,

A2780S

TumCD↑, LDH↓, MDA↑, SOD↓, ROS↑, GSH↓, Catalase↓, MMP↓, P53↑, P21↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Apoptosis↑, TumAuto↑,

4909-

Sal,

Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model

-

vitro+vivo,

CRC,

NA

AntiTum↑, Apoptosis↑, mtDam↑, ROS↑, SOD1↓, ChemoSen↑, CSCs↑, ALDH↓, TumCG↓, TumCP↓, TumCD↑, ATP↓,

4912-

Sal,

Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells

-

in-vitro,

Lung,

A549

2.5 μM

-

in-vitro,

Lung,

H460

-

in-vitro,

Lung,

Calu-1

-

in-vitro,

Lung,

H157

CSCs↓, TumAuto↑, ER Stress↑, TumCD↑, ATF4↑, CHOP/DDIT3↑, AKT1↓, mTOR↓,

6220-

Se,

CUR,

Rad,

Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy

-

in-vitro,

Lung,

A549

RadioS↑, TumCD↑, ROS↑, Imm↑, angioG↓, BioAv↑, TumCP↓, Apoptosis↓, TumMeta↓, CompStab↑,

4745-

SeNPs,

Chemo,

Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation

-

Study,

NSCLC,

NA

Risk↓, TumCD↑, mTOR↑, AntiTum↑, ChemoSen↑,

1732-

SFN,

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

-

in-vitro,

BC,

MCF7

1~5 μM

16 μM

-

in-vitro,

BC,

SUM159

10 μM

-

in-vivo,

NA,

NA

Daily injection with 50 mg/kg

mice

TumCD↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, *BioAv↑, angioG↓, VEGF↓, Hif1a↓, MMP2↓, MMP9↓, Casp3↑, *Half-Life∅,

3323-

SIL,

Anticancer therapeutic potential of silibinin: current trends, scope and relevance

-

Review,

Var,

NA

Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2/PTGS2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,

2227-

SK,

Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species

-

in-vitro,

GC,

BGC-823

13.35uM

-

in-vitro,

GC,

SGC-7901

9.63uM

-

in-vitro,

Nor,

GES-1

>20 μM

selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,

4891-

Sper,

Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms

-

Review,

Var,

NA

-

Review,

AD,

NA

TumCCA↑, TumCP↓, TumCG↓, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *mitResp↑, AntiCan↑, TumCD↑, TumAuto↑, *AntiAge↑, LC3B-II↑, ATG5↑, Beclin-1/ATG6↑, mt-ROS↑, H2O2↑, Apoptosis↑, *ROS↑, ChemoSen↑, MMP↓, Cyt‑c↑,

5077-

SSE,

Antitumor effects of sodium selenite on acute lymphocytic leukemia

-

in-vitro,

AML,

NA

TumCD↑, Apoptosis↑,

5091-

SSE,

Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite

-

in-vitro,

GBM,

U87MG

-

in-vitro,

Cerv,

HeLa

-

in-vitro,

BC,

MCF7

-

in-vitro,

Pca,

PC3

-

in-vitro,

CRC,

HT-29

-

in-vitro,

Nor,

SVGp12

Ferroptosis↑, xCT/SLC7A11↓, GSH↓, GPx4↓, Iron↑, lipid-P↑, ROS↑, eff↓, TumCP↓, TumCD↑,

5105-

SSE,

Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells

-

in-vitro,

Pca,

LNCaP

0, 0.5, 1.0, 1.5, 2.0, or 2.5 μM selenite for 5 days

TumCD↑, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, necrosis↑, chemoPv↑,

5089-

SSE,

Se,

Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line

-

in-vitro,

Pca,

LNCaP

ROS↑, mtDam↑, TumCD↑, Apoptosis↑, TumCCA↑, Trx↓, angioG↓, GSH⇅, NADPH↓, GPx↑,

5086-

SSE,

Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells

-

in-vitro,

GBM,

U87MG

-

in-vitro,

GBM,

T98G

-

in-vitro,

GBM,

A172

TumAuto↑, ROS↑, TumCD↑, tumCV↓, selectivity↑, MMP↓, eff↓, MitoP↑,

2093-

TQ,

Regulation of NF-κB Expression by Thymoquinone; A Role in Regulating Pro-Inflammatory Cytokines and Programmed Cell Death in Hepatic Cancer Cells

-

in-vitro,

Liver,

HepG2

TQ (125–1000 ug/mL).

-

in-vitro,

Nor,

NA

TumCD↑, selectivity↑, Casp3↑, DLC1↑, NF-kB↑, LDH↑, *toxicity↓,

4835-

Uro,

Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway

-

in-vitro,

SCC,

NA

TumCD↑, ER Stress↑, Akt↓, mtDam↓, p‑mTOR↓, *BioAv↝, ROS↑, TumCCA↑, Apoptosis↑, ERK↓,

1819-

VitC,

VitK3,

The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy

-

Review,

Var,

NA

Dose?, TumCD↑, selectivity↑, H2O2↑, ROS↑, DNAdam↑,

3136-

VitC,

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer

-

in-vitro,

Colon,

SW48

-

in-vitro,

Colon,

LoVo

ERK↓, p‑PKM2↓, GLUT1↓, Warburg↓, TumCD↑, eff↑, ROS↓, cMyc↓,

4468-

VitC,

SSE,

Selenium modulates cancer cell response to pharmacologic ascorbate

-

in-vivo,

GBM,

U87MG

-

in-vitro,

CRC,

HCT116

eff↓, TumCD↑, ChemoSen↑, ROS⇅, DNAdam↑, PARP↑, NAD↓, Glycolysis↓, Fenton↑, lipid-P↑, eff↓, H2O2↑, other↝,

611-

VitC,

Characterization of a new malignant human T-cell line (PFI-285) sensitive to ascorbic acid

-

in-vitro,

Var,

NA

50 mumol/l

TumCD↑,

600-

VitC,

VitK3,

Serum markers variation consistent with autoschizis induced by ascorbic acid-menadione in patients with prostate cancer

-

in-vitro,

Pca,

NA

autoS↑, TumCD↑,

628-

VitC,

Mg,

Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation

-

in-vivo,

Colon,

CT26

mouse

-

in-vitro,

NA,

MCF7

 1–10 mM(Mg)

(MgSO4 and MgCl2) no cytotoxicity at any of the tested concentrations.

-

in-vitro,

NA,

SkBr3

AntiCan↑, SVCT-2↝, TumCD↑, ROS↑, P21↑, proCasp3↑, TumVol↓, DNAdam↑, NAD↓,

1835-

VitK3,

VitC,

Potential therapeutic application of the association of vitamins C and K3 in cancer treatment

-

Review,

Var,

NA

ROS↑, TumCD↑, TumCG↓, OS↑,

1821-

VitK3,

Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration

-

in-vitro,

Oral,

NA

-

in-vitro,

Nor,

HEK293

-

in-vitro,

Nor,

HaCaT

selectivity↑, TumCD↓, BAX↑, P53↑, Bcl-2↓, p65↓, E-cadherin↑, EMT↓, Vim↓, Fibronectin↓, TumCG↓, TumCMig↓,

7919-

VT,

Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway

-

in-vitro,

AML,

U937

TumCD↑, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, chemoPv↑,

1760-

WBV,

Molecular jackhammers eradicate cancer cells by vibronic-driven action

-

in-vitro,

Melanoma,

NA

TumCD↑,

Showing Research Papers: 201 to 232 of 232
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 232

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5, Catalase↓, 3, Catalase↑, 2, Fenton↑, 2, GPx↓, 1, GPx↑, 1, GPx4↓, 2, GPx4↑, 1, GSH↓, 16, GSH↑, 1, GSH⇅, 1, GSH/GSSG↓, 2, GSR↓, 1, GSR↑, 1, H2O2↑, 11, i-H2O2↑, 1, mt-H2O2↑, 1, HO-1↓, 3, HO-1↑, 1, Iron↑, 4, Keap1↓, 1, lipid-P↓, 1, lipid-P↑, 9, MDA↑, 4, NOX2↑, 1, NQO1↑, 1, NRF2↓, 5, NRF2↑, 2, ROS↓, 8, ROS↑, 102, ROS⇅, 3, ROS↝, 1, ROS∅, 1, i-ROS↑, 2, mt-ROS↑, 7, SOD↓, 1, SOD↑, 1, SOD1↓, 1, SOD2↓, 1, SOD2↑, 1, Thiols↓, 1, Trx↓, 3, TrxR↓, 1, TrxR1?, 1, TrxR1↓, 2, xCT/SLC7A11↓, 4,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2, CDC25↓, 3, compI↓, 3, compIII↓, 1, ETC↓, 4, ETC↝, 1, Insulin↓, 1, mitResp↓, 4, mtDam↓, 1, mtDam↑, 12, OCR↓, 4, OXPHOS↓, 1, OXPHOS↑, 1, PDH↓, 2, PINK1↑, 1, SDH↓, 1, SIRT3↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1, ACC↓, 1, ACC↑, 1, ACLY↓, 1, ALAT↓, 1, AMPK↑, 4, p‑AMPK↑, 1, ATP↓, 9, ATP↑, 1, FASN↓, 2, GLS↓, 1, GlucoseCon↓, 4, Glycolysis↓, 7, Glycolysis↑, 1, GSK‐3β↑, 1, HK2?, 1, HK2↓, 4, lactateProd↓, 3, LDHA↓, 3, MCT4↓, 1, NAD↓, 2, NADPH↓, 2, NADPH↑, 1, PDK1 / PDPK1↓, 2, PFK↓, 1, PKM2↓, 2, p‑PKM2↓, 1, SIRT1↑, 1, SREBP1/SREBF1↓, 2, Warburg↓, 2,

Cell Death(tgid=5) ⓘ

AIF↑, 3, APAF1↑, 1, Apoptosis↓, 5, Apoptosis↑, 78, mt-Apoptosis↑, 1, autoS↑, 1, BAD↑, 2, Bak↑, 1, BAX?, 1, BAX↓, 1, BAX↑, 26, Bax:Bcl2↓, 1, Bax:Bcl2↑, 2, Bcl-2↓, 31, Bcl-xL↓, 5, BID↑, 2, BIM↑, 1, BNIP3?, 1, Casp↑, 8, Casp1↑, 1, Casp12↑, 1, Casp3↑, 40, cl‑Casp3↑, 12, proCasp3↓, 1, proCasp3↑, 1, pro‑Casp3↑, 1, Casp6↑, 1, Casp7↑, 6, cl‑Casp7↑, 1, Casp8↑, 7, Casp9↓, 1, Casp9↑, 19, cl‑Casp9↑, 6, pro‑Casp9↑, 1, cFLIP↓, 2, Cupro↑, 1, Cyt‑c↓, 1, Cyt‑c↑, 27, Endon↑, 1, Fas↑, 3, FasL↑, 1, Ferroptosis↑, 6, HEY1↓, 1, IAP1↓, 1, ICD↑, 1, iNOS↓, 1, Mcl-1↓, 6, MDM2↓, 1, MOMP↓, 1, MOMP↑, 5, Necroptosis↑, 2, necrosis↑, 5, p38↓, 1, p38↑, 7, p‑p38↑, 2, Paraptosis↑, 2, survivin↓, 1, TumCD?, 1, TumCD↓, 11, TumCD↑, 215, TumCD∅, 4, XIAP↓, 1, YAP/TEAD↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 23, Akt↑, 1, p‑Akt↓, 6, p‑Akt↑, 2, AKT1↓, 1, CK2↓, 1, EGFR↓, 2, p‑EGFR↓, 1, ERK↓, 7, ERK↑, 1, p‑ERK↑, 2, HER2/EBBR2↓, 1, Hippo↓, 1, IKKα↓, 1, p‑IKKα↓, 1, p‑IκB↓, 1, JAK↓, 1, JAK1↓, 1, JAK2↓, 1, JNK↓, 4, JNK↑, 5, p‑JNK↑, 2, MAPK↓, 3, MAPK↑, 2, p‑MAPK↓, 1, Mst1↑, 1, mTOR↓, 9, mTOR↑, 1, p‑mTOR↓, 3, mTORC2↓, 1, p‑p70S6↑, 1, P70S6K↓, 2, PDGFR-BB↓, 1, PI3K↓, 14, PI3K↑, 2, PKCδ↓, 1, PTEN↑, 1, STAT↓, 1, STAT3↓, 9, STAT3↑, 1, p‑STAT3↓, 3, STAT5↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1, ATF4↑, 3, ChrMod↑, 2, cMyc↓, 3, FOXM1↓, 1, FOXO1↓, 1, FOXO3↑, 1, FOXO4↑, 1, H3↑, 1, H3K4↓, 1, H3K9↓, 1, HDAC↓, 2, OCT4↓, 2, other?, 1, other↓, 2, other↑, 4, other↝, 10, PhotoS↑, 3, sonoS↑, 1, SOX2↓, 1, SOX4↓, 1, SUV39H↓, 1, TFE3↑, 1, tumCV↓, 19, tumCV↑, 1, tumCV∅, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑ATF6↑, 1, CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 5, eIF2α↑, 1, p‑eIF2α↑, 1, ER Stress↑, 16, GRP78/BiP↓, 1, GRP78/BiP↑, 4, GRP94↑, 1, HSP27↓, 1, HSP70/HSPA5↑, 2, HSP90↓, 5, IRE1↑, 1, p‑IRE1↑, 1, PERK↑, 1, p‑PERK↑, 1, Proteasome?, 1, UPR↑, 2, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2, ATG5↑, 3, Beclin-1/ATG6↑, 3, CTSB↓, 1, CTSD↓, 1, LAMP2↑, 1, LC3B-II↑, 2, LC3II↑, 1, MitoP↑, 2, p62↑, 1, p‑p62↑, 1, PARK2↑, 1, TumAuto↓, 1, TumAuto↑, 18,

DNA Damage & Repair(tgid=10) ⓘ

BRCA2↓, 2, DNAdam↑, 31, hTERT/TERT↓, 1, p16↑, 2, P53↓, 1, P53↑, 23, PARP↓, 3, PARP↑, 4, cl‑PARP↑, 17, PCNA↓, 3, γH2AX↑, 5, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5, CDK2↓, 8, CDK4↓, 7, CDK6↓, 2, CDKN2C/p18↑, 1, cellSen↑, 1, CHK1↓, 1, Chk2↓, 1, cycA1/CCNA1↓, 2, CycB/CCNB1↓, 9, cycD1/CCND1↓, 11, cycE/CCNE↓, 3, E2Fs↓, 2, Ki-67↓, 2, mitA↓, 1, mitA↑, 1, P21↓, 2, P21↑, 10, p27/CDKN1B↓, 1, p27/CDKN1B↑, 3, p‑RB1↓, 1, TumCCA↓, 2, TumCCA↑, 69,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4, CD133↓, 2, cFos↑, 1, CSCs↓, 13, CSCs↑, 1, CSCs↝, 1, Diff↓, 1, Diff↑, 2, IGF-1↓, 2, IGF-2↑, 1, Ki-67↓, 2, mTORC1↓, 1, NOTCH↓, 1, NOTCH↑, 1, NOTCH1↓, 2, TumCG?, 1, TumCG↓, 29, TumCP?, 1, TumCP↓, 37, TumCP↑, 2, TumCP∅, 1, Wnt↓, 4,

Migration(tgid=13) ⓘ

AP-1↓, 1, ATPase↓, 1, BACH1↓, 1, Ca+2↓, 1, Ca+2↑, 13, i-Ca+2↑, 1, CD11b↑, 1, i-Chl↑, 1, Cofilin↓, 1, DLC1↑, 1, E-cadherin↓, 1, E-cadherin↑, 4, EMT↓, 7, EpCAM↓, 2, FAK↓, 1, Fibronectin↓, 1, hnRNPA1↓, 1, LAMs↓, 1, LIMK2↓, 1, MMP1↓, 1, MMP15↓, 1, MMP2↓, 9, MMP9↓, 8, MMPs↓, 5, N-cadherin↓, 4, PAK1↑, 1, ROCK1↓, 1, Slug?, 1, Slug↓, 4, Snail?, 1, Snail↓, 6, TGF-β↓, 1, TIMP1↑, 1, TIMP2↓, 1, TIMP2↑, 1, TumCA↓, 1, TumCI↓, 12, TumCMig↓, 16, TumMeta↓, 18, Twist↓, 1, TXNIP↑, 1, uPA↓, 1, Vim↓, 3, Zeb1↓, 2, α-SMA↓, 1, α-tubulin↓, 2, β-catenin/ZEB1↓, 5, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 16, angioG↑, 1, HIF-1↓, 1, Hif1a↓, 4, NO↑, 2, VEGF↓, 7,

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1, CellMemb↑, 4, CLDN1↓, 1, EPR↑, 2, GLUT1↓, 3, GLUT3↓, 1, GLUT4↓, 1, MMP?, 1, MMP↓, 44, MMP↝, 1, MPT↑, 2, SVCT-2↝, 1, TRPM7↑, 1, TRPV1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2, CD44↓, 3, CD8+↑, 2, COX2/PTGS2↓, 7, COX2/PTGS2↑, 1, DCells↑, 1, DR4↑, 1, FOXP3↑, 1, HMGB1↓, 1, ICAM-1↓, 1, IL1β↓, 1, IL2↓, 1, IL6↓, 6, IL8↓, 3, Imm↑, 10, Imm↝, 1, Inflam↓, 6, M2 MC↓, 1, NF-kB↓, 21, NF-kB↑, 3, p‑NF-kB↓, 1, p65↓, 2, PD-1↓, 1, PD-L1↓, 1, PGE2↓, 1, TCF↝, 1, TNF-α↓, 3, Treg lymp↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

i-pH↓, 1, Temp↓, 1, Temp∅, 1,

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↑, 1, ER-α36↓, 1, PPARγ↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1, BioAv↑, 7, BioAv↝, 5, ChemoSen↑, 35, CompStab↑, 2, CYP3A4↓, 1, Dose?, 3, Dose↓, 2, Dose↑, 1, Dose↝, 30, Dose∅, 1, eff↓, 39, eff↑, 42, eff↝, 4, eff∅, 1, GSTP1/GSTπ↓, 1, Half-Life↓, 1, Half-Life↑, 1, Half-Life↝, 1, P-gp/ABCB1↓, 1, P-gp/ABCB1∅, 1, RadioS↑, 14, selectivity↓, 1, selectivity↑, 53, Synergy↑, 27,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AR↑, 1, BG↓, 1, BloodF↑, 1, E6↓, 2, E7↓, 1, EGFR↓, 2, p‑EGFR↓, 1, Ferritin↓, 1, FOXM1↓, 1, HER2/EBBR2↓, 1, hTERT/TERT↓, 1, IL6↓, 6, LDH?, 1, LDH↓, 3, LDH↑, 2, PD-L1↓, 1, Polyps↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 13, AntiCan⇅, 1, antiNeop↑, 1, AntiTum↑, 8, Appetite↑, 1, BowelM↑, 1, breath↑, 1, cardioP↑, 2, chemoP↑, 8, chemoPv↑, 4, ChemoSideEff↓, 2, hepatoP↑, 4, MusCon↓, 2, NP/CIPN↓, 1, OS↑, 8, OS⇅, 1, Pain↓, 2, PFS↑, 1, QoL↑, 2, radioP↑, 1, Remission↑, 1, RenoP↑, 1, Risk↓, 3, Sleep↑, 1, Strength↑, 2, toxicity↓, 7, toxicity↑, 1, toxicity↝, 3, toxicity∅, 1, TumVol↓, 13, TumW↓, 2, Weight↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1, Bacteria↓, 2, GutMicro↑, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 498

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 13, Catalase↑, 5, GPx↑, 3, GPx1↑, 1, GSH↑, 1, GSTs↑, 3, HDL↑, 1, HO-1↓, 1, HO-1↑, 1, hyperG↝, 1, Keap1↝, 1, lipid-P↓, 2, MDA↓, 2, NRF2↑, 3, Prx↑, 1, RNS↓, 2, ROS↓, 12, ROS↑, 1, ROS∅, 2, mt-ROS?, 1, SOD↓, 1, SOD↑, 2, SOD1↑, 2, SOD2↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↝, 1, Insulin↑, 1, mitResp↑, 1, PGC-1α↝, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2, AMPK↑, 1, ATP↑, 1, DGAT1↓, 1, FASN↓, 1, glucose↓, 1, LDL↓, 1, lipidLev↓, 1, SIRT1↑, 1,

Cell Death(tgid=5) ⓘ

AIF↓, 1, BAX↓, 1, Casp1↓, 1, Casp3?, 1, Casp3↓, 2, cl‑Casp3↓, 1, cl‑Casp8↓, 1, Cyt‑c↓, 1, iNOS↓, 1, TumCD↑, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

MAPK↓, 1, mTOR↓, 1, PI3K↓, 1, RIP1↓, 1, STAT3↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2, RUNX2↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1, LC3II↑, 1, p62↑, 2,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3, P53↓, 1, PARP1↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1, BMP2↑, 1, neuroG↑, 1, TumCG∅, 1,

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 1, VCAM-1↓, 2,

Barriers & Transport(tgid=15) ⓘ

MMP↑, 2, MMP∅, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2, COX2/PTGS2↑, 1, IL18↓, 1, IL1β↓, 2, IL6↓, 4, Inflam↓, 10, pol-M2 MC↑, 1, NF-kB↓, 3, PGE2↓, 1, PSA∅, 1, TNF-α↓, 4,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, 5HT↑, 1, AChE↓, 1, BDNF↑, 2, MAOA↓, 1, NGF↑, 2, β-Endo↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 1, p‑tau↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3, BioAv↑, 10, BioAv↝, 2, CompStab↝, 1, CYP2E1↓, 1, Dose↝, 1, Half-Life∅, 1, selectivity↑, 1, Synergy↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2, AST↓, 2, BMD↑, 1, BP↓, 2, HOMA↓, 1, hs-CRP↓, 1, IL6↓, 4, PSA∅, 1, TC↓, 1, TG/TAG↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 5, antiAll↑, 2, AntiCan↑, 4, antiCG↑, 1, AntiDiabetic↑, 5, antiPs↑, 1, AntiTum↓, 1, AntiTum↑, 2, cardioP↑, 1, chemoP↑, 1, cognitive↑, 3, hepatoP↑, 2, memory↑, 1, neuroP↑, 5, Obesity↓, 2, OS↑, 1, radioP↑, 1, RenoP↑, 1, Stroke↓, 2, toxicity↓, 15, toxicity↑, 2, toxicity↝, 5, toxicity∅, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1, AntiP↑, 2, AntiViral↑, 2, Bacteria↓, 4, GutMicro↑, 2,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1, Ingr↝, 2,
Total Targets: 143

Scientific Paper Hit Count for: TumCD, Tumor Cell Death

23 Silver-NanoParticles
12 Magnetic Fields
9 Vitamin C (Ascorbic Acid)
9 Magnetic Field Rotating
6 Electrical Pulses
6 Phenethyl isothiocyanate
6 Selenite (Sodium)
5 Curcumin
5 Copper and Cu NanoParticles
5 Dandelion Root
5 Disulfiram
5 Ivermectin
4 Radiotherapy/Radiation
4 Chemotherapy
4 Photodynamic Therapy
4 Metformin
4 Eugenol
4 Quercetin
4 VitK3,menadione
3 Rosmarinic acid
3 Hyperthermia
3 Astaxanthin
3 Melatonin
3 Chrysin
3 Date Fruit Extract
3 Eurycomanone
3 Fisetin
3 salinomycin
2 3-bromopyruvate
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Berberine
2 Betulinic acid
2 Benzyl isothiocyanate
2 Boron
2 α-Bisabolol / Chamomile oil
2 Caffeic acid
2 chaetocin
2 Coenzyme Q10
2 diet FMD Fasting Mimicking Diet
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Fenbendazole
2 Ginkgetin
2 Gossypol/AT-101
2 Honokiol
2 Isobavachalcone
2 phytic acid, Inositol hexakisphosphate
2 isoorientin
2 Sulforaphane (mainly Broccoli)
2 Kaempferol
2 lambertianic acid
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Methylene blue
2 Matrine
2 mebendazole
2 Magnesium
2 Methylglyoxal
2 Phenylbutyrate
2 Selenium
1 1,8-Cineole
1 2-DeoxyGlucose
1 Auranofin
1 Gold NanoParticles
1 Allyl isothiocyanate
1 Anethole/trans-Anethole
1 Anti-oxidants
1 Aloe anthraquinones
1 Baicalein
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Bullatacin
1 Carnosic acid
1 Capsaicin
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chitosan
1 Chlorophyllin
1 Docetaxel
1 Zinc
1 Cranberry
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Deguelin
1 Diclofenac
1 Echinacea
1 Cannabichromene
1 Bortezomib
1 eicosapentaenoic acid
1 ferumoxytol
1 Formononetin
1 Flaxseed/Linseed
1 Galloflavin
1 Ginkgo biloba
1 Graviola
1 Grapeseed extract
1 Hydrogen Gas
1 Hibiscus sabdariffa
1 Indole-3-carbinol
1 Inositol
1 iodine
1 Paclitaxel/Taxol
1 Isothiocyanates
1 Lactobacillus
1 Laetrile B17 Amygdalin
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lasiodin
1 Linalool
1 Luteolin
1 SonoDynamic Therapy UltraSound
1 Magnolol
1 MCT, metronomic chemo
1 Methyl Jasmonate
1 Caffeine
1 methotrexate
1 Morin
1 Mucuna pruriens/Velvet Bean
1 Mistletoe/Viscum album Extracts
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Mushroom Maitake
1 Nimbolide
1 Propyl gallate
1 Phycocyanin
1 Piperlongumine
1 Resveratrol
1 Pterostilbene
1 Perilla
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spermidine
1 Thymoquinone
1 Urolithin
1 Vitexin
1 Whole Body Vibration

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:619  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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