cycD1/CCND1 Cancer Research Results

cycD1/CCND1, cyclin D1 pathway: Click to Expand ⟱
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Type:
Also called CCND1 Gatekeeper of Cell-Cycle Commitment
The main function of cyclin D1 is to maintain cell cycle and to promote cell proliferation. Cyclin D1 is a key regulatory protein involved in the cell cycle, particularly in the transition from the G1 phase to the S phase. It is part of the cyclin-dependent kinase (CDK) complex, where it binds to CDK4 or CDK6 to promote cell cycle progression.
Cyclin D1 is crucial for the regulation of the cell cycle. Overexpression or dysregulation of cyclin D1 can lead to uncontrolled cell proliferation, a hallmark of cancer.
Cyclin D1 is often found to be overexpressed in various cancers.
Cyclin D1 can interact with tumor suppressor proteins, such as retinoblastoma (Rb). When cyclin D1 is overexpressed, it can lead to the phosphorylation and inactivation of Rb, releasing E2F transcription factors that promote the expression of genes required for DNA synthesis and cell cycle progression.
Cyclin D1 is influenced by various signaling pathways, including the PI3K/Akt and MAPK pathways, which are often activated in cancer.
In some cancers, high levels of cyclin D1 expression have been associated with poor prognosis, making it a potential biomarker for cancer progression and treatment response.
Scientific Papers found: Click to Expand⟱
7604- I3C,    Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent
2/16-OHE1↑, CYP1B1↓, 4-OHE1↓, Apoptosis↑, cycD1/CCND1↓, TumCCA↑, AntiTum↑,
7582- I3C,    Indole-3-Carbinol Promotes Apoptosis and Inhibits the Metastasis of Esophageal Squamous Cell Carcinoma by Downregulating the Wnt/β-Catenin Signaling Pathway
- vitro+vivo, ESCC, NA
Apoptosis↑, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7718- IP6,    Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes
- in-vitro, Pca, DU145
chemoPv↑, TumCG↓, TumCCA↑, P21↓, p27/CDKN1B↑, CDK2↓, CDK4↓, CDK6↓, cycE/CCNE↓, cycD1/CCND1↓, pRB↑, Apoptosis↑, cl‑PARP↑, Casp3↑,
7691- IP6,    Inositol Hexaphosphate Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target
- vitro+vivo, Pca, PC3 - in-vitro, Pca, C4-2B
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, Akt↓, PI3K↓, p‑GSK‐3β↓, cycD1/CCND1↓, TumVol↓, TumW↓, PCNA↓, angioG↓, CD31/PECAM-1↓, ILK↓, VEGF↓, eNOS↓, Hif1a↓,
1293- IP6,    Inositol Hexaphosphate Inhibits Growth and Induces G1 Arrest and Apoptotic Death of Androgen-Dependent Human Prostate Carcinoma LNCaP Cells
- vitro+vivo, Pca, LNCaP
TumCG↓, TumCCA↑, P21↑, CDK4↓, cycD1/CCND1↓, RB1↑, E2Fs↓,
7747- ISL,    Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells
- in-vitro, Melanoma, SK-MEL-28
*Inflam↓, *AntiViral↑, *AntiTum↑, *antiOx↑, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Cyt‑c↑, cycD1/CCND1↓, cycD1/CCND1↓, survivin↓, ROS↓, eff↓, p‑mTOR↓, p‑STAT3↓, p‑MAPK↓,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7786- ISL,    Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function
AntiTum↑, TumCP⇅, cycD1/CCND1↓, cycE/CCNE↓, P21↑,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
1167- IVM,    The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer
- vitro+vivo, NA, NA
Wnt↓, TCF↓, TumCP↓, Apoptosis↑, β-catenin/ZEB1↓, cycD1/CCND1↓,
2351- lamb,    Anti-Warburg effect via generation of ROS and inhibition of PKM2/β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
proCasp3↓, proPARP↓, LDHA↓, Glycolysis↓, HK2↓, PKM2↓, lactateProd↓, p‑STAT3↓, cycD1/CCND1↓, cMyc↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, ROS↑, eff↓,
1040- LE,    Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration
- in-vivo, Lung, H1975
TumCCA↑, CDK4↓, cycD1/CCND1↓, PD-L1↑, TumVol↓,
2928- LT,    Luteolin-mediated increase in miR-26a inhibits prostate cancer cell growth and induces cell cycle arrest targeting EZH2
EZH2↓, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
1171- LT,    The inhibition of β-catenin activity by luteolin isolated from Paulownia flowers leads to growth arrest and apoptosis in cholangiocarcinoma
- in-vitro, CCA, NA
Wnt↓, TumCCA↑, Apoptosis↑, TumCMig↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27/CDKN1B↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2/PTGS2↓, lipid-P↓, GSH↑, NRF2↑,
3276- Lyco,    Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma
- in-vivo, HCC, NA
G6PD↓, PCNA↓, cycD1/CCND1↓, P21↑, Hif1a↓, Glycolysis↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
1013- Lyco,    Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells
- in-vitro, GC, AGS
Apoptosis↑, DNAdam↑, Bax:Bcl2↑, ROS↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, APC↑, β-TRCP↑, cMyc↓, cycD1/CCND1↓,
4778- Lyco,    Lycopene exerts cytotoxic effects by mitochondrial reactive oxygen species–induced apoptosis in glioblastoma multiforme
- in-vitro, GBM, GBM8401
BBB↑, Apoptosis↑, TumCP↑, P53↑, CycB/CCNB1↓, cycD1/CCND1↓, TumCCA↓, mt-ROS↑, TumCG↓,
4780- Lyco,    Potential inhibitory effect of lycopene on prostate cancer
- Review, Pca, NA
TumCP↓, TumCCA↑, Apoptosis↑, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *Ca+2↝, *antiOx↑, *AntiCan↑, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *TNF-α↓, NF-kB↓, DNAdam↓, PSA↓, P53↓, cycD1/CCND1↓, NRF2↓, Akt2↓, PPARγ↓,
4784- Lyco,    Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives
- Review, Diabetic, NA - Review, CardioV, NA
*antiOx↑, *IL8↓, *IL6↓, *IL1↓, *NF-kB↓, Inflam↓, cycD1/CCND1↓, MMP2↓, MMP9↓, Bcl-2↓, NF-kB↓, *Nrf1↑, *antiOx↑, *BDNF↑, *neuroP↑, *cardioP↑, ROS↑, Dose↝,
4786- Lyco,    Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MCF7 - in-vitro, BC, SkBr3
TumCP↓, TumCCA↑, cl‑PARP↑, ERK↑, cycD1/CCND1↓, P21↓, p‑Akt↓, mTOR↓, BAX↑, AntiCan↑, Risk↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, eff↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, eff↑,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↓, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27/CDKN1B↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,
4795- Lyco,    Updates on the Anticancer Profile of Lycopene and its Probable Mechanism against Breast and Gynecological Cancer
- Review, BC, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↝, BAX↝, cycD1/CCND1↓, ERK↓, Akt↓, STAT3↓, NRF2↝, NF-kB↓, ITGB1↓, ITGA5↓, FAK↓, MMP9↓, EMT↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4516- MAG,    Magnolol Induces Apoptosis and Suppresses Immune Evasion in Non-small Cell Lung Cancer Xenograft Models
- in-vivo, NSCLC, NA
selectivity↑, Apoptosis↑, TumCCA↑, Casp3↑, cycD1/CCND1↓, CDK4↓, VEGF↓, FOXP3↓, IDO1↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, eff↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
5800- MET,    Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
- Review, Var, NA
ChemoSen↑, RadioS↑, Imm↑, *AntiDiabetic↑, *AMPK↑, TumCP↓, hepatoP↑, ATP↓, AMP↑, glucoNG↓, ROS↑, compI↓, DNAdam↑, CSCs↓, NP/CIPN↓, chemoP↑, toxicity↓, Trx↓, eff↑, cycD1/CCND1↓, CDK4↓, CDK6↓, cycE/CCNE↓, CDK2↓,
1182- MushCha,    Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29 - in-vitro, CRC, SW-620 - in-vitro, CRC, DLD1
Apoptosis↑, TumCG↓, FASN↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, CDK8↓, Ki-67↓,
930- MushShi,    Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation
- in-vitro, Ovarian, NA
p‑STAT3↓, PTPN6↑, cycD1/CCND1↓, Bcl-2↓, Mcl-1↓, survivin↓, VEGF↓,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, NA, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2/PTGS2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
1805- NarG,    Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota
- in-vitro, Ovarian, A2780S - in-vivo, NA, NA
TumCP↓, TumCMig↓, PI3K↓, TumVol↓, TumW↓, BioAv↑, GutMicro↑, Dose∅, eff↑, EGFR↓, cycD1/CCND1↓, toxicity∅,
1269- NCL,    Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway
- in-vitro, Pca, DU145
STAT3↓, TumCG↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cMyc↓, Bcl-xL↓,
1267- NCL,    Niclosamide suppresses migration of hepatocellular carcinoma cells and downregulates matrix metalloproteinase-9 expression
- in-vitro, HCC, NA
TumCP↓, cycD1/CCND1↓, MMP9↓, TumCMig↓,
6493- Nimb,    Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment
- in-vivo, CRC, HCT116 - vitro+vivo, CRC, HT29
TumCP↓, Apoptosis↑, NF-kB↓, IKKα↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, cMyc↓, cycD1/CCND1↓, MMP9↓, CXCR4↓, ICAM-1↓, VEGF↓, angioG↓, TumCG↓,
1227- OLST,    Anti-Obesity Drug Orlistat Alleviates Western-Diet-Driven Colitis-Associated Colon Cancer via Inhibition of STAT3 and NF-κB-Mediated Signaling
- in-vivo, CRC, NA
OS↑, Inflam↓, TumCG↓, STAT3↓, NF-kB↓, β-catenin/ZEB1↓, Slug↓, XIAP↓, CDK4↓, cycD1/CCND1↓, Bcl-2↓,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1676- PBG,    Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
- Review, Var, NA
ROS↑, MMP↓, Bcl-2↓, eff↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
4940- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G 0/G 1 Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, tumCV↓, ROS↑, Ca+2↑, CDC25↓, CDK6↓, cycD1/CCND1↓, CDK2↓, cycE/CCNE↓, P53↑, p27/CDKN1B↑, P21↑, Casp9↑, Casp3↑, GRP78/BiP↑,
5185- PEITC,  SFN,    Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
NF-kB↓, p65↓, VEGF↓, cycD1/CCND1↓, Bcl-xL↓, IKKα↓,
1938- PL,    Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation
- Study, PSA, NA - in-vivo, NA, NA
ROS↑, Apoptosis↑, MMP↓, TumCCA↑, DNAdam↑, STAT3↓, Akt↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, Bcl-2↓, K17↓, HDAC↓, ROS↑, *IL1β↓, *IL6↓, *TNF-α↓, *IL17↓, *IL22↓,
2940- PL,    Piperlongumine Induces Reactive Oxygen Species (ROS)-dependent Downregulation of Specificity Protein Transcription Factors
- in-vitro, PC, PANC1 - in-vitro, Lung, A549 - in-vitro, Kidney, 786-O - in-vitro, BC, SkBr3
ROS↑, TumCP↓, Apoptosis↑, eff↓, Sp1/3/4↓, cycD1/CCND1↓, survivin↓, cMyc↓, EGFR↓, cMET↓,

Showing Research Papers: 201 to 250 of 335
Prev Page 5 of 7 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 335

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,   CTSK↓, 1,   ILK↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   ARE↑, 1,   Catalase↑, 2,   compI↓, 1,   CYP1A1↓, 1,   GPx↑, 2,   GSH↑, 2,   GSR↑, 1,   GSTA1↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↓, 1,   lipid-P↓, 1,   lipid-P↑, 1,   NRF2↓, 2,   NRF2↑, 3,   NRF2↝, 1,   ROS↓, 6,   ROS↑, 20,   mt-ROS↑, 1,   SIRT3↑, 1,   SOD↑, 2,   Trx↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 3,   CDC2↓, 1,   CDC25↓, 1,   MEK↓, 1,   MKK4↓, 1,   MMP↓, 9,   mtDam↑, 3,   OCR↓, 1,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMP↑, 1,   CAIX↑, 1,   cMyc↓, 9,   p‑cMyc↑, 1,   FASN↓, 1,   G6PD↓, 1,   glucoNG↓, 1,   Glycolysis↓, 4,   HK2↓, 3,   IDO1↓, 1,   lactateProd↓, 1,   LDH↓, 4,   LDHA↓, 2,   LDL↓, 1,   PFK↓, 2,   PKM2↓, 3,   PPARγ↓, 1,   PPARγ↑, 3,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 13,   p‑Akt↓, 2,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 26,   BAX↓, 2,   BAX↑, 9,   BAX↝, 1,   Bax:Bcl2↑, 3,   Bcl-2↓, 11,   Bcl-2↑, 1,   Bcl-xL↓, 3,   BID↑, 1,   BMP2↓, 1,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 9,   cl‑Casp3↑, 4,   proCasp3↓, 1,   cl‑Casp7↑, 1,   cl‑Casp8↑, 3,   Casp9↑, 4,   cl‑Casp9↑, 2,   Chk2↓, 1,   Cyt‑c↑, 5,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 2,   hTERT/TERT↓, 2,   iNOS↓, 1,   iNOS↑, 1,   JNK↑, 3,   MAPK↓, 1,   MAPK↑, 2,   p‑MAPK↓, 1,   Mcl-1↓, 3,   MDM2↓, 1,   NICD↓, 1,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 8,   p38↓, 2,   p38↑, 1,   PUMA↑, 1,   survivin↓, 6,   Telomerase↓, 1,   YAP/TEAD↓, 1,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   H3↓, 1,   pRB↓, 1,   pRB↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 2,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3B-II↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   BRCA2↑, 1,   CHK1↓, 1,   CYP1B1↓, 1,   DNAdam↓, 2,   DNAdam↑, 6,   DNArepair↑, 1,   P53↓, 2,   P53↑, 9,   P53↝, 1,   cl‑PARP↑, 9,   proPARP↓, 1,   PCNA↓, 8,   TP53↓, 1,   γH2AX↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   p‑CDK1↓, 1,   CDK2↓, 9,   CDK2↑, 1,   CDK4↓, 14,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 5,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 50,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 11,   cycE/CCNE↑, 1,   E2Fs↓, 1,   P21?, 1,   P21↓, 3,   P21↑, 15,   RB1↑, 1,   TumCCA↓, 2,   TumCCA↑, 22,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CDK8↓, 1,   cFos↓, 1,   cMET↓, 1,   CSCs↓, 2,   EMT↓, 3,   ERK↓, 3,   ERK↑, 1,   p‑ERK↓, 1,   FOXO3↓, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 4,   HDAC↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC8↓, 1,   HH↓, 1,   IGF-1R↓, 1,   mTOR↓, 8,   p‑mTOR↓, 1,   NOTCH1↓, 1,   P70S6K↓, 1,   PI3K↓, 8,   PTEN↓, 1,   PTEN↑, 1,   PTPN6↑, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 9,   p‑STAT3↓, 3,   TAZ↓, 1,   TCF↓, 1,   TOP2↑, 1,   TumCG↓, 11,   TumCG↑, 1,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   Akt2↓, 1,   APC↑, 1,   Ca+2↑, 3,   i-Ca+2↑, 1,   CD31/PECAM-1↓, 1,   CLDN2↓, 1,   E-cadherin↑, 3,   ER-α36↓, 1,   F-actin↓, 1,   FAK↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   Ki-67↓, 5,   MMP13↓, 1,   MMP2↓, 10,   MMP7↓, 2,   MMP9↓, 13,   MMP9↑, 1,   MMPs↓, 1,   N-cadherin↓, 1,   PAK1↓, 1,   PDGF↓, 1,   Slug↓, 1,   TIMP1↓, 2,   TIMP1↑, 1,   TIMP2↑, 1,   Treg lymp↓, 1,   TumCI↓, 6,   TumCMig↓, 9,   TumCP↓, 19,   TumCP↑, 1,   TumCP⇅, 1,   TumMeta↓, 3,   TumMeta↑, 2,   Vim↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   EGFR↓, 3,   eNOS↓, 1,   eNOS↑, 1,   Hif1a↓, 4,   NO↓, 1,   VEGF↓, 10,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 6,   CXCR4↓, 2,   FOXP3↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 1,   IKKα↓, 2,   IL1↑, 1,   IL10↓, 3,   IL1β↓, 1,   IL2↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 3,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 3,   JAK↓, 1,   JAK1↓, 1,   NF-kB↓, 19,   p‑NF-kB↑, 1,   NK cell↑, 1,   p65↓, 3,   PD-L1↑, 1,   PGE2↓, 1,   PSA↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 2,   TNF-α↓, 3,   TNF-α↑, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 5,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↓, 2,   ChemoSen↑, 12,   Dose↝, 2,   Dose∅, 4,   eff↓, 3,   eff↑, 19,   MDR1↓, 1,   RadioS↑, 6,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BRCA1↑, 1,   EGFR↓, 3,   EZH2↓, 1,   GutMicro↑, 1,   hTERT/TERT↓, 2,   IL6↓, 3,   Ki-67↓, 5,   LDH↓, 4,   PD-L1↑, 1,   PSA↓, 1,   TP53↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↑, 3,   chemoP↑, 2,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 1,   K17↓, 1,   NP/CIPN↓, 1,   OS↑, 3,   radioP↑, 1,   Risk↓, 3,   toxicity↓, 2,   toxicity∅, 1,   TumVol↓, 3,   TumW↓, 2,  
Total Targets: 317

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 10,   ARE↑, 1,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 1,   HO-1↑, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 3,   ROS↓, 4,   SOD↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   CRM↑, 1,   glucose↓, 1,   glyC↓, 1,   NADPH↑, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   iNOS↓, 2,   JNK↓, 1,   MAPK↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1↓, 2,   IL17↓, 1,   IL1β↓, 1,   IL22↓, 1,   IL6↓, 3,   IL8↓, 2,   Inflam↓, 6,   Inflam↑, 1,   NF-kB↓, 4,   PGE2↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↑, 1,   BDNF↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 2,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 4,   hepatoP↑, 1,   neuroP↑, 6,   Risk↓, 1,   toxicity↓, 3,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 2,  
Total Targets: 62

Scientific Paper Hit Count for: cycD1/CCND1, cyclin D1 pathway
20 Quercetin
19 Thymoquinone
16 Curcumin
14 Fisetin
11 Lycopene
10 Resveratrol
9 Boswellia (frankincense)
8 Garcinol
7 Berberine
7 Chrysin
7 Ferulic acid
7 Honokiol
6 Sulforaphane (mainly Broccoli)
5 Silver-NanoParticles
5 Apigenin (mainly Parsley)
5 Artemisinin
5 Baicalein
5 D-limonene
5 Ellagic acid
5 Eugenol
5 Gallic acid
5 Magnolol
5 salinomycin
5 Silymarin (Milk Thistle) silibinin
5 Shikonin
4 Caffeic acid
4 Metformin
4 Formononetin
4 HydroxyTyrosol
4 Isoliquiritigenin
4 Piperlongumine
3 Cisplatin
3 Beta-Caryophyllene
3 Betulinic acid
3 Capsaicin
3 Carvacrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Ursolic acid
3 EGCG (Epigallocatechin Gallate)
3 Gambogic Acid
3 Ginkgetin
3 Indole-3-carbinol
3 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
3 Luteolin
3 Propolis -bee glue
3 Vitamin K2
2 Sorafenib (brand name Nexavar)
2 Astragalus
2 Allicin (mainly Garlic)
2 Anethole/trans-Anethole
2 Astaxanthin
2 Berbamine
2 Bufalin/Huachansu
2 Chemotherapy
2 Carnosic acid
2 Celastrol
2 Cucurbitacin
2 Cyclopamine
2 Ginger/6-Shogaol/Gingerol
2 Graviola
2 Hibiscus sabdariffa
2 Niclosamide (Niclocide)
2 Phenethyl isothiocyanate
2 VitK3,menadione
2 Rosmarinic acid
1 2-DeoxyGlucose
1 Alpha-Lipoic-Acid
1 Andrographis
1 Gemcitabine (Gemzar)
1 Fennel Oil/Foeniculum vulgare
1 Isovitexin
1 Ashwagandha(Withaferin A)
1 Radiotherapy/Radiation
1 borneol
1 Boron
1 Butyrate
1 Caffeine
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chlorogenic acid
1 Chlorophyllin
1 Crocetin
1 Dihydrocaffeic Acid
1 Docosahexaenoic Acid
1 diet Methionine-Restricted Diet
1 tamoxifen
1 Dandelion Root
1 Disulfiram
1 Copper and Cu NanoParticles
1 Emodin
1 Evodiamine
1 Fenbendazole
1 Fucoidan
1 chitosan
1 Geraniol
1 Ginseng
1 5-fluorouracil
1 Grapeseed extract
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 chaetocin
1 Baicalin
1 isoorientin
1 Ivermectin
1 lambertianic acid
1 Licorice
1 Melatonin
1 Mushroom Chaga
1 Mushroom Shiitake, AHCC
1 Myricetin
1 Naringin
1 Nimbolide
1 Orlistat
1 Plumbagin
1 Pterostilbene
1 doxorubicin
1 Paclitaxel/Taxol
1 Rauwolfia serpentina/Indian Snakeroot
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Urolithin
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:73  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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