cycD1/CCND1 Cancer Research Results

cycD1/CCND1, cyclin D1 pathway: Click to Expand ⟱
Source:
Type:
Also called CCND1 Gatekeeper of Cell-Cycle Commitment
The main function of cyclin D1 is to maintain cell cycle and to promote cell proliferation. Cyclin D1 is a key regulatory protein involved in the cell cycle, particularly in the transition from the G1 phase to the S phase. It is part of the cyclin-dependent kinase (CDK) complex, where it binds to CDK4 or CDK6 to promote cell cycle progression.
Cyclin D1 is crucial for the regulation of the cell cycle. Overexpression or dysregulation of cyclin D1 can lead to uncontrolled cell proliferation, a hallmark of cancer.
Cyclin D1 is often found to be overexpressed in various cancers.
Cyclin D1 can interact with tumor suppressor proteins, such as retinoblastoma (Rb). When cyclin D1 is overexpressed, it can lead to the phosphorylation and inactivation of Rb, releasing E2F transcription factors that promote the expression of genes required for DNA synthesis and cell cycle progression.
Cyclin D1 is influenced by various signaling pathways, including the PI3K/Akt and MAPK pathways, which are often activated in cancer.
In some cancers, high levels of cyclin D1 expression have been associated with poor prognosis, making it a potential biomarker for cancer progression and treatment response.
Scientific Papers found: Click to Expand⟱
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,
4523- HNK,  MAG,  BA,    Honokiol-Magnolol-Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti-PD-1 Immunotherapy in Colorectal Cancer by Triggering GSDME-Dependent Pyroptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, LoVo - in-vivo, CRC, HCT116
AntiCan↑, eff↑, TumCP↓, TumCCA↓, cycD1/CCND1↓, Pyro↑, Apoptosis↑, cl‑GSDME↑, Bcl-2↓, Cyt‑c↑, Casp9↑, TumCG↓,
7542- HT,    Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Nor, RWPE-1
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,
4636- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/ß-catenin and TGFß signaling
- in-vitro, BC, SUM159 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, BC, BT549
Wnt↓, β-catenin/ZEB1↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, TGF-β↓, CSCs↓, TumCMig↓, chemoP↑,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
4632- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, SUM159
CSCs↓, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, Wnt↓, p‑LRP6↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, SMAD2↓, SMAD3↓, TGF-β↓,
7604- I3C,    Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent
- in-vitro, Var, NA
2/16-OHE1↑, CYP1B1↓, 4-OHE1↓, Apoptosis↑, cycD1/CCND1↓, TumCCA↑, AntiTum↑,
7582- I3C,    Indole-3-Carbinol Promotes Apoptosis and Inhibits the Metastasis of Esophageal Squamous Cell Carcinoma by Downregulating the Wnt/β-Catenin Signaling Pathway
- vitro+vivo, ESCC, NA
Apoptosis↑, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7718- IP6,    Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes
- in-vitro, Pca, DU145
chemoPv↑, TumCG↓, TumCCA↑, P21↓, p27/CDKN1B↑, CDK2↓, CDK4↓, CDK6↓, cycE/CCNE↓, cycD1/CCND1↓, pRB↑, Apoptosis↑, cl‑PARP↑, Casp3↑,
7691- IP6,    Inositol Hexaphosphate Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target
- vitro+vivo, Pca, PC3 - in-vitro, Pca, C4-2B
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, Akt↓, PI3K↓, p‑GSK‐3β↓, cycD1/CCND1↓, TumVol↓, TumW↓, PCNA↓, angioG↓, CD31/PECAM-1↓, ILK↓, VEGF↓, eNOS↓, Hif1a↓,
1293- IP6,    Inositol Hexaphosphate Inhibits Growth and Induces G1 Arrest and Apoptotic Death of Androgen-Dependent Human Prostate Carcinoma LNCaP Cells
- vitro+vivo, Pca, LNCaP
TumCG↓, TumCCA↑, P21↑, CDK4↓, cycD1/CCND1↓, RB1↑, E2Fs↓,
7747- ISL,    Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells
- in-vitro, Melanoma, SK-MEL-28
*Inflam↓, *AntiViral↑, *AntiTum↑, *antiOx↑, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Cyt‑c↑, cycD1/CCND1↓, cycD1/CCND1↓, survivin↓, ROS↓, eff↓, p‑mTOR↓, p‑STAT3↓, p‑MAPK↓,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7786- ISL,    Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function
- in-vitro, Var, NA
AntiTum↑, TumCP⇅, cycD1/CCND1↓, cycE/CCNE↓, P21↑,
7866- isoO,    Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,
8009- itraC,    Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways
- vitro+vivo, Melanoma, SK-MEL-28 - vitro+vivo, Melanoma, A375
OS↑, TumCP↓, Ki-67↓, TumCP↓, Gli1↓, GLI2↓, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, AXIN1↑, GLI3↑, AXIN1↑, HH↓, PI3K↓, Akt↓, *toxicity↓,
1167- IVM,    The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer
- vitro+vivo, Var, NA
Wnt↓, TCF↓, TumCP↓, Apoptosis↑, β-catenin/ZEB1↓, cycD1/CCND1↓,
8038- IVM,    Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction
- in-vitro, PC, NA
*AntiP↑, AntiTum↑, ChemoSen↑, TumCP↓, TumCCA↑, cycD1/CCND1↓, mTOR↓, STAT3↑, Apoptosis↑, mtDam↑, ROS↑, MMP↓, OCR↓, MitoP↓,
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,
7965- JG,    Mechanistic investigation of Juglone (5-hydroxy-1,4-naphthoquinone) as an anti-cancer agent in human colorectal cancer HCT116 and HT-29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
Apoptosis↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Bcl-2↓, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, ERK↓, AKT1↓, p38↑, JNK↑, TumCMig↓, TumCI↓, TumMeta↓,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8148- lamb,    Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
- in-vitro, Pca, LNCaP
*antiAll↑, *Bacteria↓, AR↓, PSA↓, TumCCA↑, CDK4↓, CDK6↓, cycD1/CCND1↓, P53↑, P21↑, p27/CDKN1B↓, Apoptosis↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Dose↝,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
2351- lamb,    Anti-Warburg effect via generation of ROS and inhibition of PKM2/β-catenin mediates apoptosis of lambertianic acid in prostate cancer cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
proCasp3↓, proPARP↓, LDHA↓, Glycolysis↓, HK2↓, PKM2↓, lactateProd↓, p‑STAT3↓, cycD1/CCND1↓, cMyc↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, ROS↑, eff↓, Warburg↓,
8161- LapC,    Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells
- in-vitro, ESCC, KYSE-30 - in-vitro, ESCC, KYSE450 - in-vitro, ESCC, KYSE-510
RSK2/RPS6KA3/p90RSK2↓, TumCG↓, Apoptosis↑, Casp3↑, Casp7↑, PARP↑, Cyt‑c↑, BAX↑, p‑CREB↓, ATF1↓, H3↓, CycB/CCNB1↓, cycD1/CCND1↓, p‑CDK2↓,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,
8244- LCA,    Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest
- in-vitro, Liver, HepG2
TumCP↓, ROS↑, TumCCA↑, Apoptosis↑, survivin↓, CycB/CCNB1↓, CDK1↓, WEE1↑, P21↑, cycD1/CCND1↑, JNK↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR5↑, Casp3↑, Casp8↑, Casp10↑, Fas↑, BAD↑, BAX↑, PUMA↑, PKCδ↓, P70S6K↓, Akt↓,
8253- LCA,    Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma
- in-vitro, SCC, HSC4
*AntiTum↑, *angioG↓, *AntiP↑, *antiOx↑, *Bacteria↓, *Inflam↓, tumCV↓, Sp1/3/4↓, p27/CDKN1B↑, P21↑, cycD1/CCND1↓, Mcl-1↓, survivin↓, Apoptosis↑,
8233- LCA,    Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
- in-vitro, Lung, NA
TumCP↓, selectivity↑, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, BAX↑, PARP1↑, Casp3↑, Bcl-2↓, MAPK↓, FBXO5/EMI1↓, TumVol↓, TumW↓, toxicity↓,
8232- LCA,    Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study
- vitro+vivo, ESCC, NA
TumCP↓, TumCMig↓, TumCI↓, MMPs↓, ROS↑, MMP↓, BAX↑, Casp3↑, Casp9↑, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK1↓, P53↑, TumCG↓, toxicity↓,
8222- LCA,    Licochalcone A Induces Cholangiocarcinoma Cell Death Via Suppression of Nrf2 and NF-κB Signaling Pathways
- in-vitro, CCA, KKU-100 - in-vitro, CCA, KKU-213 - in-vitro, CCA, KKU-214 - in-vitro, CCA, KKU-156 - in-vitro, 0-Reserved, KKU-452
TumCP?, TumCD?, ROS↑, NRF2↓, BAX↑, Cyt‑c↑, TumCMig↓, TumCCA↑, NF-kB↓, STAT3↓, cycD1/CCND1↓, VEGF↓, ICAM-1↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8265- LE,    Glycyrrhizin ameliorates colorectal cancer progression by regulating NHEJ pathway through inhibiting HMGB1-induced DNA damage response
- vitro+vivo, CRC, NA
TumCG↓, Inflam↓, tumCV↓, DNAdam↑, Apoptosis↑, Casp3↑, TumCCA↑, cycD1/CCND1↓, HMGB1↓, NHEJ↓, TumCP↓,
8282- LE,    Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, GC, MGC803 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901
Ingr↝, TumCP↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, BAX↑, PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, Bcl-2↓, survivin↓, p65↓, p‑PI3K↓, p‑Akt↓,
8272- LE,    Glycyrrhizin upregulates PTEN and suppresses oncogenic signaling in breast cancer
- in-vitro, BC, NA
PTEN↑, cycD1/CCND1↓, α-tubulin↓, TumCCA↑, AntiCan↑,
1040- LE,    Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration
- in-vivo, Lung, H1975
TumCCA↑, CDK4↓, cycD1/CCND1↓, PD-L1↑, TumVol↓,
8197- LGE,    Citral induced apoptosis in MDA-MB-231 spheroid cells
- in-vitro, BC, MDA-MB-231
eff↓, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓,
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,
2928- LT,    Luteolin-mediated increase in miR-26a inhibits prostate cancer cell growth and induces cell cycle arrest targeting EZH2
- in-vitro, Pca, NA
EZH2↓, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
1171- LT,    The inhibition of β-catenin activity by luteolin isolated from Paulownia flowers leads to growth arrest and apoptosis in cholangiocarcinoma
- in-vitro, CCA, NA
Wnt↓, TumCCA↑, Apoptosis↑, TumCMig↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓,
8343- Lut,    Association of Lutein with Cancer: A Systematic Review of the Lutein Effects on Cellular Processes Involved in Cancer Progression
- Review, Var, NA
*antiOx↑, *Inflam↓, Risk↓, AntiCan∅, Apoptosis↑, ROS↓, NRF2↓, Akt↓, ERK↓, NF-kB↓, Bcl-2↓, BAX↑, Casp3↑, DNAdam↑, ROS↓, P53↑, PCNA↓, cycD1/CCND1↓, TumCP↓, Hif1a↓, NOTCH↓, miR-590-3p↑, TumCMig↓, TumCI↓, TumMeta↓, TumCA↓, *BioAv↓,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27/CDKN1B↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2/PTGS2↓, lipid-P↓, GSH↑, NRF2↑,
3276- Lyco,    Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma
- in-vivo, HCC, NA
G6PD↓, PCNA↓, cycD1/CCND1↓, P21↑, Hif1a↓, Glycolysis↓,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
1013- Lyco,    Lycopene induces apoptosis by inhibiting nuclear translocation of β-catenin in gastric cancer cells
- in-vitro, GC, AGS
Apoptosis↑, DNAdam↑, Bax:Bcl2↑, ROS↓, β-catenin/ZEB1↓, p‑GSK‐3β↓, APC↑, β-TRCP↑, cMyc↓, cycD1/CCND1↓,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
8407- Lyco,    Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines
- in-vitro, Pca, LNCaP
CholSyn↓, HMGCR↓, RAS↓, NF-kB↓, ROS↓, p‑Jun↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, p‑Akt↓, P21↑, p27/CDKN1B↑, P53↑, Bax:Bcl2↑,

Showing Research Papers: 201 to 250 of 381
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 381

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 6,   ARE↑, 1,   Catalase↑, 3,   ENOX2↓, 1,   Fenton↑, 1,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 3,   GSH↓, 14,   GSH↑, 6,   GSH/GSSG↓, 2,   GSR↓, 1,   GSR↑, 1,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 8,   HO-2↓, 1,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   MPO↓, 1,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 12,   NRF2↝, 2,   Prx4↑, 1,   PYCR1↓, 1,   ROS↓, 20,   ROS↑, 148,   ROS⇅, 6,   ROS↝, 2,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 2,   mt-ROS↑, 2,   SOD↓, 3,   SOD↑, 5,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 3,   TAC?, 1,   Thiols↓, 1,   Trx↓, 1,   TrxR↓, 2,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   BCR↓, 1,   Bfl-1↓, 1,   CDC16↓, 1,   CDC2↓, 6,   CDC25↓, 11,   compI↓, 2,   EGF↓, 2,   ETC↓, 1,   mitResp↓, 2,   MKK7↓, 1,   mtDam↑, 14,   OCR↓, 5,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 1,   PDH↝, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 6,   ACC↑, 4,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 3,   ALAT↝, 1,   ALDOA↓, 1,   AMACR↓, 1,   AMP↑, 1,   AMPK↓, 3,   AMPK↑, 15,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 12,   ATP↑, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   CholSyn↓, 1,   ECAR↓, 3,   ECAR↝, 1,   FAO↑, 1,   FASN↓, 4,   G6PD↓, 1,   GLS↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 6,   GlucoseCon∅, 1,   Glycolysis↓, 19,   GSK‐3β↓, 11,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 8,   H2S↑, 1,   Histones↑, 1,   HK1↓, 1,   HK2↓, 15,   IDO1↓, 1,   lactateProd↓, 8,   lactateProd∅, 1,   LDHA↓, 4,   LDL↓, 3,   NADPH↓, 3,   NADPH↑, 1,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   PFK↓, 3,   PKM2↓, 11,   PPP↓, 1,   SIRT1↓, 5,   SIRT1↑, 4,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 11,   APAF1↑, 6,   Apoptosis?, 3,   Apoptosis↓, 6,   Apoptosis↑, 173,   Apoptosis↝, 1,   Apoptosis∅, 1,   mt-Apoptosis↑, 3,   ASC↑, 1,   aSmase↝, 1,   BAD↓, 3,   BAD↑, 7,   Bak↑, 5,   BAX↓, 5,   BAX↑, 106,   BAX⇅, 1,   BAX↝, 3,   Bax:Bcl2↑, 30,   Bcl-2↓, 138,   Bcl-2↑, 3,   Bcl-2↝, 2,   Bcl-xL↓, 56,   Bcl-xL↑, 1,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 7,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 7,   BNIP3↑, 2,   BOK↑, 1,   Casp↓, 1,   Casp↑, 22,   Casp1↓, 1,   Casp1↑, 2,   Casp10↓, 1,   Casp10↑, 3,   Casp10∅, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 133,   Casp3↝, 2,   cl‑Casp3↑, 18,   proCasp3↓, 1,   proCasp3↑, 1,   Casp7?, 1,   Casp7↑, 19,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 28,   Casp8∅, 1,   cl‑Casp8↑, 5,   proCasp8↑, 2,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 73,   cl‑Casp9↑, 9,   proCasp9↑, 1,   cFLIP↓, 6,   CSR1↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 66,   Cyt‑c↝, 2,   mt-Cyt‑c↓, 1,   Diablo↑, 15,   DR5↓, 1,   DR5↑, 18,   DR5∅, 1,   FADD↑, 2,   FADD∅, 1,   Fas↓, 1,   Fas↑, 11,   FasL↓, 1,   FasL↑, 3,   Ferroptosis↑, 4,   cl‑GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 13,   IAP2/BIRC3↓, 6,   IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 1,   iNOS↓, 17,   iNOS↑, 1,   Mcl-1↓, 28,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 10,   MDM2↑, 1,   NAIP↓, 1,   necrosis↑, 1,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 6,   p38↑, 14,   p‑p38↓, 2,   p‑p38↑, 1,   PUMA↓, 1,   PUMA↑, 6,   Pyro↑, 2,   RIP1↓, 1,   survivin↓, 81,   TNFR 1↑, 1,   TRAIL↑, 5,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 1,   TumCD↑, 8,   XIAP↓, 29,   XIAP↝, 1,   YAP/TEAD↓, 4,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 100,   Akt↑, 4,   Akt↝, 2,   p‑Akt↓, 32,   AKT1↓, 3,   Akt2↓, 2,   CaMKII ↓, 1,   CDC7↓, 1,   CIP2A↓, 1,   CK2↓, 2,   cMET↓, 4,   CREB↓, 1,   p‑CREB↓, 1,   cSrc↓, 3,   EF-1α↓, 1,   EGFR↓, 36,   EGFR↝, 1,   p‑EGFR↓, 3,   EphB4↓, 1,   ERK↓, 31,   ERK↑, 7,   p‑ERK↓, 15,   p‑ERK↑, 1,   FGFR1↓, 1,   FLT4↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   IGF-1R↓, 8,   IGFR↓, 1,   IKKα↓, 10,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 2,   p‑IκB↓, 1,   JAK↓, 5,   JAK1?, 1,   JAK1↓, 7,   p‑JAK1↓, 1,   JAK2↓, 22,   p‑JAK2↓, 3,   JNK↓, 5,   JNK↑, 16,   JNK↝, 1,   p‑JNK↓, 2,   MAPK↓, 20,   MAPK↑, 6,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   MEK↓, 4,   MKK4↓, 2,   mTOR↓, 49,   mTOR↝, 2,   p‑mTOR↓, 8,   mTORC2↓, 3,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 4,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 75,   PI3K↝, 2,   p‑PI3K↓, 5,   PI3K/Akt↓, 2,   PKA↓, 1,   PKCδ↓, 7,   PTEN↓, 1,   PTEN↑, 18,   PTEN↝, 1,   PTPN6↑, 1,   Raf↓, 5,   c-Raf↓, 1,   RAS↓, 8,   RSK2/RPS6KA3/p90RSK2↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 13,   Src↓, 2,   c-Src↓, 1,   STAT↓, 4,   STAT3↓, 70,   STAT3↑, 2,   p‑STAT3↓, 21,   p‑STAT3↑, 2,   STAT4↓, 1,   STAT5↓, 6,   STAT6↓, 3,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 7,   ATF4↝, 1,   ATFs↑, 1,   CBP↓, 1,   CBP↑, 1,   cJun↓, 6,   cJun↑, 2,   p‑cJun↑, 1,   cMyc↓, 63,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 2,   DNMTs↓, 2,   EZH2↓, 5,   FOXM1↓, 7,   FOXO↑, 3,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 2,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 3,   H4↑, 1,   ac‑H4↑, 2,   ac‑H4∅, 1,   HATs↓, 4,   HATs↑, 2,   HDAC↓, 17,   HDAC1↓, 6,   HDAC10↓, 1,   HDAC2↓, 5,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 2,   IRF1↑, 1,   miR-130a↓, 2,   miR-149↑, 1,   miR-155↓, 1,   miR-192-5p↑, 1,   miR-200b↑, 2,   miR-200c↑, 1,   miR-21↓, 4,   miR-27a-3p↓, 3,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-34a↑, 9,   miR-590-3p↑, 1,   miR-99↑, 1,   MTA2↓, 1,   Myc↓, 4,   n-MYC↓, 2,   OCT4↓, 11,   other↓, 3,   other↑, 2,   other↝, 2,   PAX2↓, 1,   PCAF↓, 2,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 9,   SOX4↓, 2,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   SPP1↓, 1,   SUV39H↓, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV?, 1,   tumCV↓, 47,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

c-ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 16,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 4,   p‑eIF2α↑, 4,   ER Stress↓, 1,   ER Stress↑, 32,   GRP78/BiP↓, 1,   GRP78/BiP↑, 12,   GRP78/BiP↝, 1,   Hsc70↓, 1,   HSF1↓, 1,   HSP27↓, 4,   HSP27↝, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 3,   HSP70/HSPA5↝, 1,   HSP90↓, 8,   IRE1↑, 4,   PERK↑, 4,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 5,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   ATG5↑, 3,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 2,   LC3II↓, 2,   LC3II↑, 8,   LC3s↑, 1,   MitoP↓, 1,   p62↓, 3,   p62↑, 2,   PARK2↑, 1,   TumAuto↓, 1,   TumAuto↑, 16,   TumAuto⇅, 1,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 6,   p‑ATM↑, 1,   ATR↑, 2,   p‑ATR↑, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↑, 1,   DNA-PK↓, 1,   DNAdam↓, 3,   DNAdam↑, 53,   DNArepair↓, 3,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC4/XPF↓, 1,   FEN1↓, 1,   HR↓, 1,   hTERT/TERT↓, 14,   Ku70/XRCC6↓, 1,   MSH2↑, 1,   NHEJ↓, 1,   p16↑, 6,   P53?, 1,   P53↓, 5,   P53↑, 83,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 4,   ac‑P53↑, 1,   PARP↓, 2,   PARP↑, 10,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 67,   proPARP↓, 1,   PARP1↓, 2,   PARP1↑, 4,   PCNA↓, 42,   PCNA↑, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 7,   TOP1↓, 3,   TOP2↓, 5,   TOP2↑, 2,   TP53↓, 1,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 7,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK1↑, 1,   p‑CDK1↓, 2,   CDK1/2/5/9↓, 1,   CDK1/2/5/9∅, 1,   CDK2↓, 75,   CDK2↑, 4,   p‑CDK2↓, 1,   CDK4↓, 106,   CDK4↑, 2,   CDK4∅, 1,   p‑CDK4↓, 1,   CDK4/6↓, 4,   CDK6↓, 39,   CDK6↑, 3,   CDK6∅, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 1,   CHK1↓, 2,   CHK1↑, 3,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 4,   p‑Chk2↑, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 3,   CycB/CCNB1↓, 26,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 366,   cycD1/CCND1↑, 8,   cycD1/CCND1↝, 2,   cycD1/CCND1∅, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 64,   cycE/CCNE↑, 5,   cycE1↓, 5,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 10,   FBXO5/EMI1↓, 1,   Ki-67↓, 25,   MAD↓, 1,   mitA↓, 1,   mitA↑, 1,   P21?, 2,   P21↓, 8,   P21↑, 108,   P21↝, 2,   p27/CDKN1B↓, 6,   p27/CDKN1B↑, 56,   pRB↓, 2,   pRB↑, 2,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 4,   p‑RB1↓, 8,   Securin↓, 2,   TumCCA?, 1,   TumCCA↓, 8,   TumCCA↑, 220,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 5,   ALDH1A1↓, 4,   AXIN1↑, 2,   Axin2↓, 1,   BMP2↓, 1,   BMPs↑, 1,   CD133↓, 9,   CD24↓, 1,   cFos↓, 7,   CSCs↓, 33,   Diff↓, 2,   Diff↑, 2,   EIF4E↓, 1,   EP300↑, 1,   FBXW7↝, 1,   FGF↓, 1,   Gli↓, 2,   Gli1↓, 10,   HH↓, 9,   HMGCR↓, 1,   IGF-1↓, 6,   IGF-1↑, 1,   IGF-2↓, 1,   IGFBP3↑, 1,   Jun↓, 1,   p‑Jun↓, 1,   Ki-67↓, 25,   Let-7↑, 4,   LGR5↓, 1,   LRP6↓, 3,   p‑LRP6↓, 1,   mTORC1↓, 8,   p‑mTORC1↓, 1,   Nanog↓, 11,   Nestin↓, 2,   NF2↑, 1,   NICD↓, 1,   NOTCH↓, 12,   NOTCH⇅, 1,   NOTCH1↓, 11,   NOTCH1↑, 2,   NOTCH2↓, 1,   NOTCH3↓, 2,   p300↓, 3,   PTCH1↓, 4,   SCF↓, 1,   SFRP5↑, 1,   Shh↓, 9,   Smo↓, 3,   STAT1↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG?, 1,   TumCG↓, 73,   TumCG↑, 1,   TumCP?, 1,   TumCP↓, 140,   TumCP↑, 2,   TumCP⇅, 1,   tyrosinase↓, 1,   URGCP/URG4↓, 1,   Wnt↓, 35,   Wnt↑, 1,   Wnt/(β-catenin)↓, 7,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↓, 1,   AP-1↓, 9,   AP-1↝, 1,   APC↑, 1,   ATPase↓, 1,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↑, 21,   Ca+2↝, 3,   i-Ca+2↑, 2,   cal2↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   Cdc42↑, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 36,   EMT↓, 49,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 6,   p‑FAK↓, 3,   Fibronectin↓, 5,   GIT1↓, 1,   GLI2↓, 4,   GLI3↑, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 2,   ITGB1↓, 1,   ITGB1↑, 1,   LAMs↓, 2,   LEF1↓, 2,   MALAT1↓, 1,   MET↓, 3,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 2,   MMP2↓, 70,   MMP2↝, 1,   MMP3↓, 5,   MMP7↓, 14,   MMP9↓, 88,   MMP9↑, 1,   MMPs↓, 18,   MUC4↓, 2,   N-cadherin↓, 21,   NCAM↑, 1,   NM23↑, 1,   p44↓, 1,   PAK1↓, 1,   PAK1↑, 1,   p‑pax↓, 1,   PDGF↓, 3,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Slug↓, 10,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 3,   SMAD3↑, 1,   p‑SMAD3↓, 2,   p‑SMAD4↓, 1,   Snail↓, 21,   TET1↑, 2,   TGF-β↓, 13,   TGF-β↑, 1,   TIMP1↓, 2,   TIMP1↑, 9,   TIMP2↑, 7,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 2,   TumCI↓, 54,   TumCI↑, 2,   TumCMig↓, 58,   TumCMig↑, 1,   TumMeta↓, 45,   TumMeta↑, 4,   Twist↓, 19,   uPA↓, 17,   uPAR↓, 1,   Vim↓, 28,   Zeb1↓, 13,   α-SMA↓, 3,   α-tubulin↓, 3,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 56,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 55,   angioG↑, 1,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 7,   Endoglin↑, 1,   eNOS↓, 2,   eNOS↑, 1,   HIF-1↓, 2,   Hif1a↓, 42,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 5,   NO↑, 2,   VCAM-1↓, 1,   VEGF↓, 84,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 13,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 2,   CLDN2↓, 2,   EPR↑, 2,   GLUT1↓, 6,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 3,   MMP↓, 79,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 2,   SLC12A5↝, 1,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD44↓, 9,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 72,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCR4↓, 17,   CXCR4↑, 1,   DR4↑, 6,   DR4∅, 1,   FOXP3↓, 3,   FOXP3↑, 1,   Gal-3↓, 1,   HCAR2↑, 1,   HLA↑, 1,   HMGB1↓, 2,   ICAM-1↓, 8,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 8,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 1,   IL4↑, 1,   IL6↓, 37,   IL6↑, 1,   IL6↝, 1,   IL7↓, 1,   IL8↓, 8,   Imm↑, 5,   Imm↝, 1,   Inflam↓, 26,   Inflam↝, 1,   IRAK1↓, 1,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   MIP2↓, 2,   NF-kB↓, 125,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 2,   p65↓, 9,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 2,   PD-L1↓, 5,   PD-L1↑, 1,   PGE2↓, 15,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 1,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 2,   TCF↓, 4,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 1,   TLR4↓, 5,   TLR4↝, 1,   TNF-α↓, 26,   TNF-α↑, 6,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,   TRAF1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   PLC↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 14,   AR↝, 1,   ER-α36↓, 2,   ER(estro)↓, 2,   ERα/ESR1↓, 1,   PPARα↓, 2,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 6,   PRL↓, 1,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 20,   BioAv↑, 24,   BioAv↝, 5,   BioEnh↑, 4,   ChemoSen↓, 3,   ChemoSen↑, 104,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 3,   CYP1B1↓, 1,   CYP1B1↑, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 26,   Dose∅, 10,   DrugR↓, 1,   eff↓, 26,   eff↑, 38,   eff↝, 7,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↝, 7,   MDR1↓, 5,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 12,   P450↓, 3,   RadioS↑, 27,   selectivity?, 1,   selectivity↑, 52,   Synergy↑, 68,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 3,   ALAT↝, 1,   ALP↓, 3,   ALP↝, 1,   AR↓, 14,   AR↝, 1,   ascitic↓, 2,   AST↓, 1,   AST↝, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   CRP↓, 2,   EGFR↓, 36,   EGFR↝, 1,   p‑EGFR↓, 3,   ERα/ESR1↓, 1,   EZH2↓, 5,   Ferritin↓, 1,   FOXM1↓, 7,   HEC1↓, 1,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 14,   IL6↓, 37,   IL6↑, 1,   IL6↝, 1,   LDH↓, 10,   Myc↓, 4,   NOS2↓, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 1,   TP53↓, 1,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 26,   AntiCan∅, 1,   antiNeop↑, 2,   AntiTum↑, 11,   cachexia↓, 1,   cardioP↑, 7,   CardioT↓, 1,   chemoP↑, 15,   chemoPv↑, 15,   ChemoSideEff↓, 4,   FTO↑, 1,   hepatoP↑, 10,   IMPDH1↓, 1,   IMPDH2↓, 1,   K17↓, 1,   neuroP↑, 7,   NKG2D↑, 1,   NP/CIPN↓, 2,   OS↑, 9,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 5,   TGFβR1↑, 1,   toxicity↓, 9,   toxicity↑, 2,   toxicity↝, 1,   toxicity∅, 2,   TumVol↓, 24,   TumVol↑, 1,   TumW↓, 9,   Weight↓, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 1007

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 46,   ARE↑, 1,   Catalase↑, 20,   GPx↑, 16,   GSH↑, 20,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 8,   H2O2↓, 2,   HDL↑, 2,   HO-1↓, 1,   HO-1↑, 11,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 13,   MDA↓, 14,   MDA↑, 1,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↑, 23,   RNS↓, 1,   ROS↓, 45,   mt-ROS?, 1,   SOD↓, 1,   SOD↑, 23,   Trx↑, 1,   Trx1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   Insulin↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 4,   adiP↑, 1,   ALAT↓, 5,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP↑, 1,   CRM↑, 1,   ECAR∅, 1,   FASN↓, 1,   glucose↓, 5,   glucose↝, 1,   glyC↓, 1,   LDL↓, 1,   lipidLev↓, 2,   NAD↑, 1,   NADPH↑, 2,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 2,   BAX↓, 2,   Bcl-2↑, 1,   Casp↓, 1,   Casp3↓, 4,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 9,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 1,   CREB↑, 1,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 3,   IκB?, 1,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 4,   MAPK↑, 2,   PI3K↓, 3,   PI3K↑, 1,   PTEN↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other?, 1,   other↝, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   p16↓, 1,   P53↓, 1,   P53↑, 1,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   Ki-67↓, 1,   P21↓, 1,   P21↑, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

ACTA2↓, 1,   AntiAg↑, 6,   Ca+2↓, 1,   Ca+2↝, 2,   COL1A1↓, 1,   LRP1↑, 1,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MUC1↑, 1,   Rho↓, 1,   TGF-β↓, 2,   TumCI↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   E-sel↓, 1,   Hif1a↓, 2,   NO↓, 3,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   GastroP↑, 1,   IBI↑, 2,   MMP↑, 3,   MUC5AC↓, 1,   TRPC1↓, 1,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 15,   COX2/PTGS2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 2,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL22↓, 1,   IL6↓, 16,   IL8↓, 3,   Imm↑, 2,   Inflam↓, 50,   Inflam↑, 1,   IRF3↓, 1,   pol-M2 MC↑, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 23,   NLRP3↓, 1,   PGE2↓, 6,   PGE2↑, 1,   RAGE↓, 2,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 3,   TNF-α↓, 14,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 5,   AChE↑, 1,   BDNF↑, 5,   GABA↑, 2,   MAOA↓, 1,   NGF↑, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 8,   BACE/β-secretase↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   FGF21↑, 1,   GPER↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 15,   BioAv↑, 16,   BioAv↝, 6,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↝, 1,   eff↑, 3,   GSTA1↑, 1,   Half-Life↝, 4,   Half-Life∅, 1,   P450↓, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   AST↓, 7,   BMD↑, 2,   BP↓, 4,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6↓, 16,   LDH↓, 4,   LDH↑, 1,   RAGE↓, 2,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 10,   AntiArt↑, 6,   AntiCan↑, 8,   AntiDiabetic↑, 10,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP?, 1,   cardioP↑, 21,   chemoP↑, 2,   chemoPv↑, 4,   cognitive↑, 9,   hepatoP↑, 15,   Learn↑, 1,   memory↑, 12,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 37,   Obesity↓, 5,   OS↑, 1,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 5,   Risk↓, 1,   Stroke↓, 4,   toxicity↓, 13,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 4,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiP↑, 4,   AntiViral↑, 3,   Bacteria↓, 9,   GutMicro↑, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 263

Scientific Paper Hit Count for: cycD1/CCND1, cyclin D1 pathway
20 Quercetin
19 Thymoquinone
16 Curcumin
14 Fisetin
13 Lycopene
10 Resveratrol
9 Boswellia (frankincense)
8 Garcinol
7 Berberine
7 Chrysin
7 Sulforaphane (mainly Broccoli)
7 Ferulic acid
7 Honokiol
7 Magnolol
6 Silver-NanoParticles
6 Licochalcone A
5 Apigenin (mainly Parsley)
5 Artemisinin
5 Baicalein
5 D-limonene
5 Ellagic acid
5 Eugenol
5 Gallic acid
5 Licorice
5 Morin
5 salinomycin
5 Silymarin (Milk Thistle) silibinin
5 Shikonin
4 Cisplatin
4 Caffeic acid
4 Metformin
4 Indole-3-carbinol
4 Formononetin
4 HydroxyTyrosol
4 Isoliquiritigenin
4 Luteolin
4 doxorubicin
4 Piperlongumine
3 Beta-Caryophyllene
3 Betulinic acid
3 Capsaicin
3 Carvacrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Ursolic acid
3 Diindolylmethane
3 EGCG (Epigallocatechin Gallate)
3 Gambogic Acid
3 Ginkgetin
3 phytic acid, Inositol hexakisphosphate
3 Ivermectin
3 lambertianic acid
3 Propolis -bee glue
3 Vitamin K2
2 Sorafenib (brand name Nexavar)
2 Astragalus
2 Allicin (mainly Garlic)
2 Anethole/trans-Anethole
2 Astaxanthin
2 Berbamine
2 Bufalin/Huachansu
2 Chemotherapy
2 Carnosic acid
2 Celastrol
2 Cucurbitacin
2 Cyclopamine
2 tamoxifen
2 Flaxseed/Linseed
2 Ginger/6-Shogaol/Gingerol
2 Graviola
2 Hibiscus sabdariffa
2 Melatonin
2 Methylsulfonylmethane
2 Mushroom Chaga, Inonotus obliquus
2 Niclosamide (Niclocide)
2 Phenethyl isothiocyanate
2 VitK3,menadione
2 Rosmarinic acid
1 2-DeoxyGlucose
1 Alpha-Lipoic-Acid
1 Andrographis
1 Gemcitabine (Gemzar)
1 Fennel Oil/Foeniculum vulgare
1 Isovitexin
1 Ashwagandha(Withaferin A)
1 Radiotherapy/Radiation
1 borneol
1 Boron
1 Butyrate
1 Caffeine
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chlorogenic acid
1 Chlorophyllin
1 Crocetin
1 Dihydrocaffeic Acid
1 Docosahexaenoic Acid
1 diet Methionine-Restricted Diet
1 Dandelion Root
1 Disulfiram
1 Copper and Cu NanoParticles
1 Emodin
1 Evodiamine
1 Fenbendazole
1 SDG/lignans
1 Fucoidan
1 chitosan
1 Geraniol
1 Ginseng
1 5-fluorouracil
1 Grapeseed extract
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 chaetocin
1 Baicalin
1 isoorientin
1 itraconazole
1 Juglone
1 Kaempferol
1 Lapachol
1 Lemongrass Extract/Citral
1 Lutein
1 Matrine
1 Modified Citrus Pectin
1 Lemon Balm/Melissa officinalis
1 Mucuna pruriens/Velvet Bean
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Mushroom Shiitake, AHCC
1 Myricetin
1 Naringin
1 Nimbolide
1 Orlistat
1 Plumbagin
1 Pterostilbene
1 Paclitaxel/Taxol
1 Rauwolfia serpentina/Indian Snakeroot
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Urolithin
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:73  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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