Cyt‑c Cancer Research Results

Cyt‑c, cyt-c Release into Cytosol: Click to Expand ⟱
Source:
Type:
Cytochrome c
** The term "release of cytochrome c" ** an increase in level for the cytosol.
Small hemeprotein found loosely associated with the inner membrane of the mitochondrion where it plays a critical role in cellular respiration. Cytochrome c is highly water-soluble, unlike other cytochromes. It is capable of undergoing oxidation and reduction as its iron atom converts between the ferrous and ferric forms, but does not bind oxygen. It also plays a major role in cell apoptosis.

The term "release of cytochrome c" refers to a critical step in the process of programmed cell death, also known as apoptosis.
In its new location—the cytosol—cytochrome c participates in the apoptotic signaling pathway by helping to form the apoptosome, which activates caspases that execute cell death.
Cytochrome c is a small protein normally located in the mitochondrial intermembrane space. Its primary role in healthy cells is to participate in the electron transport chain, a process that helps produce energy (ATP) through oxidative phosphorylation.
Mitochondrial outer membrane permeability leads to the release of cytochrome c from the mitochondria into the cytosol.
The release of cytochrome c is a pivotal event in apoptosis where cytochrome c moves from the mitochondria to the cytosol, initiating a chain reaction that leads to programmed cell death.

On the one hand, cytochrome c can promote cancer cell survival and proliferation by regulating the activity of various signaling pathways, such as the PI3K/AKT pathway. This can lead to increased cell growth and resistance to apoptosis, which are hallmarks of cancer.
On the other hand, cytochrome c can also induce apoptosis in cancer cells by interacting with other proteins, such as Apaf-1 and caspase-9. This can lead to the activation of the intrinsic apoptotic pathway, which can result in the death of cancer cells.
Overexpressed in Breast, Lung, Colon, and Prostrate.
Underexpressed in Ovarian, and Pancreatic.
Scientific Papers found: Click to Expand⟱
2496- FBZ,    Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2/PTGS2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, eff↑, ChemoSen↑,
2844- FIS,    Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells
- in-vitro, OS, U2OS
tumCV↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, BAD↑, Bcl-2↓, Bcl-xL↓, PI3K↓, Akt↓, ERK↓, p‑JNK↑, p‑cJun↑, p‑p38↑, ROS↑, MMP↓, mTORC1↓, PTEN↑, p‑GSK‐3β↓, GSK‐3β↑, NF-kB↓, IKKα↑, Cyt‑c↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2828- FIS,    Fisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
- Review, Var, NA
*neuroP↑, *antiOx↑, *Inflam↓, RenoP↑, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, Casp3↑, Ca+2↑, Casp8↑, TumCCA↑, CDK1↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, *P53↓, *P21↓, *p16↓, mTORC1↓, mTORC2↓, P53↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, BAX↑, Bcl-2↓, PCNA↓, HER2/EBBR2↓, Cyt‑c↑, MMP↓, cl‑Casp9↑, MMP2↓, MMP9↓, cl‑PARP↑, uPA↓, DR4↑, DR5↑, ROS↓, AIF↑, CDC25↓, Dose↑, CHOP/DDIT3↑, ROS↑, cMyc↓, cardioP↑,
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,
2838- FIS,    Fisetin induces apoptosis in colorectal cancer cells by suppressing autophagy and down-regulating nuclear factor erythroid 2-related factor 2 (Nrf2)
cl‑Casp3↑, cl‑PARP↑, MMP↓, Cyt‑c↑, ROS↑, NRF2↓,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6917- FIS,    Dietary flavonoid fisetin regulates aluminium chloride-induced neuronal apoptosis in cortex and hippocampus of mice brain
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *Dose↝, *Aβ↓, *ASK1↓, *p‑JNK↓, *P53↓, *Cyt‑c↓, *Casp9↓, *Bax:Bcl2↝,
6899- FIS,    Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1
Dose↝, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↑, CDK4↑, CDK6↑, P21↑, p27/CDKN1B↑, Apoptosis↑, cl‑PARP↑, Cyt‑c↑, XIAP↓, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, PI3K↓, Akt↓,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, eff↑, *toxicity↓, *BioAv↑, *BioAv↑, *eff↑,
6986- Form,    Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway
- in-vitro, NA, NA
other↝, AntiCan↑, VEGF↓, Apoptosis↑, Bax:Bcl2↑, cl‑Casp3↑, cl‑Casp9↑, Cyt‑c↑, Hif1a↓, MEK↓, ERK↓, VEGFR2/KDR/Flk1↓, angioG↓,
6969- Form,    Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer
- vitro+vivo, NSCLC, HCC827 - in-vitro, NSCLC, A549 - in-vitro, Lung, H1299
EGFR↓, Akt↓, GSK‐3β↑, TumCG↓, ChemoSen↑, Mcl-1↓, RadioS↑, tumCV↓, selectivity↑, Dose↝, Cyt‑c↑, BAX↑, Apoptosis↑, Ki-67↓, toxicity↓, chemoPv↑,
7005- Fuc,    Fucoidan and cancer: a multifunctional molecule with anti-tumor potential
- Review, Var, NA
AntiCan↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, MMP↓, Casp9↑, survivin↓, IAP1↓, Cyt‑c↑, Diablo↑, Bak↑, XIAP↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, Akt↓, eff↝, TumMeta↓,
4028- FulvicA,    Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells
- in-vitro, Liver, HUH7
Apoptosis↑, TumCP↓, ROS↑, NO↑, Dose↝, MMP↓, Cyt‑c↑, SOD↓, Catalase↓, GSH↑, lipid-P↑, miR-21↓, miR-22↑,
1086- GA,    Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation
- in-vitro, AML, K562
tumCV↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,
7059- GamB,    Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells
- in-vitro, CRC, HCT15
TumCP↓, Apoptosis↑, JNK↑, TumCCA↑, cycD1/CCND1↓, P53↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, MMP↓, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓,
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, PI3K↓, Akt↓, STAT3↓, STAT5↓, IL6↓, COX2/PTGS2↓, iNOS↓, MMPs↓, Src↓, PKA↓, CXCR4↑, VEGF↓, Bcl-2↓, Bcl-xL↓, IAP1↓, Mcl-1↓, survivin↓, cycD1/CCND1↓, HSP90↓, HSP70/HSPA5↓, MAPK↓, HATs↓, HDAC↓, FAK↓, ROS↑, MMP7↓, MMP9↓, α-tubulin↑, cl‑PARP↑, TNF-α↓, BID↑, BAD↑, Cyt‑c↑, Casp3↑, Casp9↑, *AntiArt↑, *antiPs↑,
1959- GamB,    Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells
- in-vitro, Ovarian, NA - in-vivo, NA, NA
AntiCan↑, Pyro↑, tumCV?, CellMemb↓, cl‑Casp3↑, GSDME-N↑, ROS?, p‑P53↑, eff↓, MMP↓, Bcl-2↓, BAX↑, mtDam↑, Cyt‑c↑, TumCG↓, CD4+↑, CD8+↑,
1967- GamB,    Gambogic acid induces apoptotic cell death in T98G glioma cells
- in-vitro, GBM, T98G
BAX↑, AIF↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↓, Bcl-2↓, ROS↑,
1969- GamB,    Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells
- in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
AntiTum↑, TumCI↓, Apoptosis↑, ROS↑, Cyt‑c↑, Akt↓, mTOR↓, TumCG↓, TumMeta↓,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,
831- GAR,  CUR,    Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, Casp3↑, MMP↓, Cyt‑c↑, proCasp9↑, Bcl-2↓, BAX↑, PARP↓, DNAdam↑, DFF45↓,
830- GAR,    Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells
- in-vitro, CRC, HT-29
TumCI↓, TumCMig↓, Apoptosis↑, p‑FAK↓, Src↓, MAPK↓, ERK↓, PI3K/Akt↓, Bax:Bcl2↑, Cyt‑c↑, MMP7↓,
7226- GBE,    Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells involving MAPK signaling pathways
- vitro+vivo, Lung, NA
TumCP↓, selectivity↑, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, Casp3↑, Fas↑, FasL↑, Dose↝, TumCG↓,
7217- GGB,    Role of Ginkgolides in the Inflammatory Immune Response of Neurological Diseases: A Review of Current Literatures
- Review, AD, NA
*eff↑, *AntiAg↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *MAPK↓, *NF-kB↓, *PAF↓, *TLR1↓, *MyD88↓, *BDNF↑, *ROS↓, *PARP↓, *Cyt‑c↓,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
7264- Gink,    Anti-tumor effect of ginkgetin on human hepatocellular carcinoma cell lines by inducing cell cycle arrest and promoting cell apoptosis
- vitro+vivo, HCC, HepG2 - NA, HCC, SK-HEP-1
tumCV↓, TumCCA↓, Casp3↑, Cyt‑c↑, TumCG↓, Dose↝,
7266- Gink,    Ginkgo biloba derivative ginkgetin inhibits breast cancer growth by regulating the miRNA-122-5p/GALNT10 axis
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453 - in-vitro, BC, MCF7
Casp3↑, BAX↑, Cyt‑c↑, Bcl-2↓, TumCP↓, TumCMig↓, Apoptosis↑, miR-122-5p↑, GALNT10↓, TumCG↓,
7315- Gos,    Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells
- vitro+vivo, CRC, HT29 - in-vitro, CRC, COLO205
TumCD↑, Casp3↑, Casp6↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-xL↓, ROS↑, i-H2O2↑, eff↓, mtDam↑, MMP↓, Cyt‑c↑, AIF↑, TumCG↓,
7310- Gos,    Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells
- in-vitro, AML, NA
TumCD↑, MOMP↑, ROS↑, ATP↓, BAX↑, Cyt‑c↑, AIF↑,
7335- Gra,    Effect of Annona muricata (Soursop) on Patients with Cancer: A Systematic Review
- Review, Var, NA
TumCG↓, Casp↑, Inflam↓, toxicity↓, other↑, TumCCA↑, Apoptosis↑, TumAuto↑, ATP↓, AIF↑, MMP↓, MOMP↑, Cyt‑c↑, selectivity↑, hepatoP∅,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
835- Gra,    Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB
- in-vitro, Lung, A549
ROS↑, MMP↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, Apoptosis↑, TumCCA↑,
858- Gra,    Annona muricata leaves induce G₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑, BAX↑, Bcl-2↓, TumCMig↓, TumCI↓,
1232- Gra,    Graviola: A Systematic Review on Its Anticancer Properties
- Review, NA, NA
EGFR↓, cycD1/CCND1↓, Bcl-2↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, BAX↑, Cyt‑c↑, Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ATP↓,
1657- HCAs,    Anticancer Activity of Sinapic Acid by Inducing Apoptosis in HT-29 Human Colon Cancer Cell Line 2023
- in-vitro, CRC, HT-29
cl‑Casp3↑, BAX↑, cl‑PARP↑, γH2AX↑, Cyt‑c↑,
7370- HibSad,    Hibiscus sabdariffa leaf induces apoptosis of human prostate cancer cells in vitro and in vivo
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, DU145
eff↑, Dose↝, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, FasL↑, eff↑, TumW↓, TumVol↓, other↝,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
7363- HibSad,    Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation
Apoptosis↑, selectivity↑, p‑p38↑, JNK↑, cJun↑, Cyt‑c↑, Fas↑, FasL↑,
7357- HibSad,    Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells
- in-vitro, CRC, LoVo
Apoptosis↑, AMPK↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑Casp3↑, Dose↝, mtDam↑, MMP↓, Akt↓,
7350- HibSad,    Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway
- in-vitro, GC, AGS
TumCD↑, DNAdam↑, P53↑, Bcl-2↓, Mcl-1↓, Cyt‑c↑, FasL↑, Fas↑, p38↑, BAX↑, Dose↝, TumCCA↑,
7463- HNK,    Honokiol Inhibits Colorectal Cancer Cell Growth: Involvement of Hsp27 as a Molecular Target
- in-vitro, CRC, NA
TumCG↓, TumCCA↑, Cyt‑c↑, Apoptosis↑, cl‑PARP↑, Bcl-2↓, HSP27↓,
2879- HNK,    Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function
- in-vitro, Lung, H226 - in-vivo, NA, NA
tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,

Showing Research Papers: 201 to 250 of 408
Prev Page 5 of 9 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 408

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

GALNT10↓, 1,   miR-122-5p↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ATF3↑, 1,   Catalase↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   GSH↑, 1,   GSTs↓, 1,   GSTs↝, 1,   i-H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 2,   Keap1↓, 1,   lipid-P↓, 2,   lipid-P↑, 1,   NRF2↓, 4,   NRF2↑, 3,   ROS?, 1,   ROS↓, 5,   ROS↑, 25,   mt-ROS↑, 2,   SOD↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 6,   ATP↓, 4,   CDC2↓, 3,   CDC25↓, 4,   EGF↓, 2,   MEK↓, 2,   mitResp↓, 1,   MMP↓, 24,   mtDam↑, 4,   OCR↓, 1,   XIAP↓, 5,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 2,   AMP↑, 1,   AMPK↑, 6,   cMyc↓, 1,   CYP3A4↓, 1,   FASN↓, 1,   HK2↓, 1,   LDH↓, 1,   LDHA↓, 1,   PCK1↓, 1,   PI3K/Akt↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 16,   APAF1↑, 1,   Apoptosis↑, 25,   BAD↑, 4,   Bak↑, 2,   BAX↑, 22,   Bax:Bcl2↑, 5,   Bcl-2↓, 24,   Bcl-xL↓, 5,   BID↑, 2,   BIM↑, 3,   Casp↑, 7,   Casp3↑, 23,   cl‑Casp3↑, 8,   Casp6↑, 1,   Casp7↑, 2,   Casp8↑, 11,   cl‑Casp8↑, 2,   Casp9↑, 16,   cl‑Casp9↑, 5,   proCasp9↑, 1,   cFLIP↓, 1,   Chk2↑, 1,   Cyt‑c↑, 48,   Diablo↑, 6,   DR4↑, 1,   DR5↑, 5,   FADD↑, 1,   Fas↓, 1,   Fas↑, 8,   FasL↑, 6,   Ferroptosis↑, 1,   GSDME-N↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 2,   JNK↑, 4,   p‑JNK↑, 1,   MAPK↓, 7,   Mcl-1↓, 10,   MDM2↓, 2,   MOMP↑, 3,   Myc↓, 1,   NOXA↑, 1,   p27/CDKN1B↑, 4,   p38↓, 2,   p38↑, 2,   p‑p38↓, 1,   p‑p38↑, 2,   Pyro↑, 1,   survivin↓, 7,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↑, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 2,   p70S6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 5,   cJun↑, 2,   p‑cJun↑, 1,   p‑H3↓, 1,   HATs↓, 1,   miR-21↓, 1,   other↑, 1,   other↝, 2,   tumCV?, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   ER Stress↑, 4,   GRP78/BiP↑, 4,   HSF1↓, 1,   HSP27↓, 3,   HSP27↝, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↝, 1,   HSP90↓, 3,   IRE1↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1↑, 2,   LC3II↑, 1,   LC3s↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   CHK1↑, 1,   DFF45↓, 1,   DNAdam↑, 10,   P53?, 1,   P53↓, 1,   P53↑, 11,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 17,   PCNA↓, 4,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 10,   CDK2↑, 1,   CDK4↓, 11,   CDK4↑, 1,   cycA1/CCNA1↓, 2,   cycD1/CCND1↓, 15,   cycE/CCNE↓, 7,   mitA↑, 1,   P21↑, 9,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↓, 1,   TumCCA↑, 25,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CD44↓, 1,   cFos↓, 6,   CSCs↓, 1,   EMT↓, 5,   ERK↓, 7,   p‑ERK↓, 1,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   IGF-1↓, 1,   mTOR↓, 10,   mTORC1↓, 5,   mTORC2↓, 3,   PI3K↓, 9,   PTEN↑, 2,   RAS↓, 1,   Src↓, 2,   STAT3↓, 3,   STAT5↓, 1,   TCF↑, 1,   TCF-4↓, 2,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 13,   Wnt↓, 7,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   BACH1↓, 1,   Ca+2↑, 3,   CCN2/CTGF↓, 1,   CD31/PECAM-1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 4,   FAK↓, 1,   p‑FAK↓, 1,   Fibronectin↓, 2,   Ki-67↓, 2,   LAMs↓, 1,   MET↓, 1,   miR-22↑, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 9,   MMP3↓, 2,   MMP7↓, 7,   MMP9↓, 10,   MMPs↓, 2,   N-cadherin↓, 3,   PKA↓, 1,   PKCδ↓, 1,   RAGE↓, 1,   Rho↓, 1,   Snail↓, 2,   TET1↓, 1,   TGF-β↓, 1,   TIMP2↑, 1,   TumCA↓, 1,   TumCI↓, 7,   TumCMig↓, 4,   TumCP↓, 7,   TumMeta↓, 6,   Twist↓, 2,   uPA↓, 9,   Vim↓, 4,   Zeb1↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   ATF4↓, 1,   ATF4↑, 3,   EGFR↓, 10,   eNOS↓, 1,   Hif1a↓, 3,   NO↓, 1,   NO↑, 2,   VEGF↓, 9,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↓, 1,   GLUT1↓, 1,   GLUT4↓, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 10,   CXCR4↑, 1,   IKKα↑, 2,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 2,   JAK1↓, 1,   NF-kB↓, 16,   NF-kB↑, 1,   p65↓, 1,   PD-1↓, 1,   PGE2↓, 4,   TNF-α↓, 3,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 4,   CDK6↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↝, 2,   ChemoSen↑, 10,   Dose↑, 1,   Dose↝, 11,   eff↓, 2,   eff↑, 11,   eff↝, 2,   Half-Life↓, 1,   Half-Life↝, 1,   P450↝, 1,   RadioS↑, 6,   selectivity↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 10,   HER2/EBBR2↓, 2,   IL6↓, 2,   Ki-67↓, 2,   LDH↓, 1,   Myc↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 2,   hepatoP↑, 1,   hepatoP∅, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 3,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 293

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   PAF↓, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   HO-1↓, 1,   HO-1↑, 1,   Keap1↝, 1,   MDA↓, 2,   NRF2↑, 3,   ROS↓, 3,   mt-ROS?, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↑, 1,   Insulin↑, 1,   MMP↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   p‑cMyc↑, 1,   glucose↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   ASK1↓, 1,   Bax:Bcl2↝, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   p‑JNK↓, 1,   MAPK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p16↓, 1,   P53↓, 2,   PARP↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   VCAM-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↑, 1,   IL18↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 5,   pol-M2 MC↑, 1,   MyD88↓, 1,   NF-kB↓, 3,   TLR1↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 2,   NGF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   Dose↝, 1,   eff↓, 1,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   antiPs↑, 2,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 4,   Obesity↓, 1,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,  
Total Targets: 80

Scientific Paper Hit Count for: Cyt‑c, cyt-c Release into Cytosol
16 Betulinic acid
15 Curcumin
15 Fisetin
14 Silver-NanoParticles
14 Baicalein
14 Sulforaphane (mainly Broccoli)
12 Apigenin (mainly Parsley)
12 Quercetin
11 Thymoquinone
10 Berberine
10 Emodin
9 Allicin (mainly Garlic)
9 Capsaicin
9 Phenethyl isothiocyanate
8 Carvacrol
8 Chrysin
7 Honokiol
7 Magnetic Fields
6 EGCG (Epigallocatechin Gallate)
6 Eugenol
6 Gambogic Acid
6 Juglone
6 Luteolin
6 Silymarin (Milk Thistle) silibinin
5 Artemisinin
5 Graviola
5 Hibiscus sabdariffa
5 isoorientin
5 Resveratrol
5 Vitamin K2
4 3-bromopyruvate
4 Cisplatin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Thymol-Thymus vulgaris
4 Magnolol
4 Nimbolide
4 Shikonin
4 Selenite (Sodium)
3 Ashwagandha(Withaferin A)
3 Photodynamic Therapy
3 Crocetin
3 Dichloroacetate
3 D-limonene
3 Dandelion Root
3 Ellagic acid
3 Formononetin
3 Garcinol
3 Ginkgetin
3 Indole-3-carbinol
3 Lycopene
3 Magnetic Field Rotating
3 Propolis -bee glue
3 Rosmarinic acid
3 Spermidine
2 Chemotherapy
2 Celastrol
2 Citric Acid
2 Copper and Cu NanoParticles
2 Ursolic acid
2 Cynaropicrin
2 salinomycin
2 Diclofenac
2 Electrical Pulses
2 Eurycomanone
2 Radiotherapy/Radiation
2 Evodiamine
2 Gossypol/AT-101
2 Hyperthermia
2 HydroxyTyrosol
2 Hyperoside
2 Isoliquiritigenin
2 Phenylbutyrate
2 Piperine
2 Piperlongumine
2 Plumbagin
2 Aflavin-3,3′-digallate
1 1,8-Cineole
1 5-fluorouracil
1 Coenzyme Q10
1 Astragalus
1 chemodynamic therapy
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 Gemcitabine (Gemzar)
1 Ajoene (compound of Garlic)
1 Alpha-Lipoic-Acid
1 alpha Linolenic acid
1 Andrographis
1 Metformin
1 2-DeoxyGlucose
1 Biochanin A
1 Bufalin/Huachansu
1 Bromelain
1 Boron
1 Butyrate
1 Cat’s Claw
1 chaetocin
1 Chlorophyllin
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Cinnamon
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Fenbendazole
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Ginkgo biloba
1 Ginkgolide B
1 Hydroxycinnamic-acid
1 Baicalin
1 Isobavachalcone
1 iodine
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Isovitexin
1 Methylene blue
1 Iron
1 Methylglyoxal
1 Pterostilbene
1 Kaempferol
1 Paclitaxel/Taxol
1 Rauwolfia serpentina/Indian Snakeroot
1 α-Santalol/Sandalwood oil
1 Selenium
1 chitosan
1 Selenium NanoParticles
1 Docetaxel
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 VitK3,menadione
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:77  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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