Risk Cancer Research Results

Risk, Risk: Click to Expand ⟱
Source:
Type:
Risk: by definition reduces risk of disease or cancer.
Down Target direction of risk indicates lower cancer risk.
ChemoPreventive also mean lower cancer risk. But for Chemopreventive an up arrow indicates more preventive. 
Cancer Risk Impact Score (CRIS)
CRIS scale:
–5 = very strong risk reduction
–4 = strong risk reduction
–3 = moderate risk reduction
–2 = modest risk reduction
–1 = weak / context-dependent
0 = neutral




CRIS Exposure / Compound Evidence Cancers Notes




-5 Exercise (overall)
VStrong Hum BC, CRC, Endo, PCa, Liv






-5 Aerobic + resistance VStrong Hum Broad inc + mort






-4 Aerobic exercise (mod–vig) VStrong Hum BC, CRC, Endo






-4 Resistance training (alone) Strong Hum BC, CRC






-3 High-intensity interval training Mod–Strong Hum BC, CRC






-2 NEAT / low-intensity activity Moderate Hum CRC






-5 Cruciferous vegetable pattern Strong Hum Lung, CRC, BC, PCa






-5 Sunlight exposure (physiologic) Strong Hum CRC, BC, PCa






-4 Fasting (metabolic pattern)
Strong Mech + Hum BC, CRC, PCa 






-4 Curcumin
Hum + Pre GI, BC, PCa






-4 Sulforaphane
Hum + Pre Lung, CRC, BC






-4 PEITC
Hum + Pre Lung, CRC, PCa






-4 EGCG (tea matrix)
Strong Hum GI, PCa, BC






-4 Lycopene
Strong Hum PCa






-4 Apigenin
Pre + Diet Hum BC, PCa, CRC 






-4 Luteolin
Pre + Diet Hum Lung, CRC, BC 






-4 Kaempferol
Diet Hum Ov, Panc, Lung






-4 Fisetin
Pre + Early Hum CRC, PCa, Mel






-4 Ellagic acid → Urolithin A
Hum (microbiome) CRC, PCa, BC






-3 Omega-3 (EPA/DHA)
Strong Hum CRC, BC






-3 Vitamin D3 (supp)
Obs + RCT CRC, BC






-3 Garlic (allicin)
Mod Hum GI






-3 Mushroom beta-glucans
Hum adjunct GI, BC






-3 Melatonin
Hum + Mech BC, PCa






-3 Coffee (whole)
Strong Hum Liv, Endo






-2 Quercetin
Limited Hum Lung, CRC






-2 Resveratrol
Limited Hum CRC, BC






-2 I3C / DIM
Mod Hum BC, Cerv






-2 Thymoquinone
Early Hum BC, CRC






-2 Beta-carotene (food)
Hum Lung






-1 Vitamin K2 (MK-4/7)
Limited Hum Liv, PCa






-1 Boron
Obs PCa, Lung






0 Vitamin C (oral)
Strong Hum —






0 Genistein (soy)
Strong Hum BC, PCa






0 Selenium (diet)
Mixed Hum PCa






0 Capsaicin
Mixed Gastric






+2 Vitamin E (alpha only)
Strong RCT PCa






+2 Green tea extract (high-dose)
Case reports Liv






+4 Beta-carotene (supplement)
Strong RCT Lung (smokers)






+5 Alcohol (ethanol)
Strong Hum BC, Liv, Eso







Evidence
Hum        human data
VStrong    very strong
Strong     strong
Mod        moderate
Obs        observational
Pre        preclinical
RCT        randomized controlled trial
Mech       mechanistic
Adjunct    adjunct clinical use


Scientific Papers found: Click to Expand⟱
8458- Mg,    Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial
- Trial, CRC, NA
*GutMicro↑, *VitD↑, Risk↓,
8461- Mg,    Effects of Salivary Mg on Head and Neck Carcinoma via TRPM7
- vitro+vivo, SCC, CAL27 - in-vitro, Laryn, FaDu
TumCP↑, TumCMig↑, TumCI↑, TumCG↑, TRPM7↑, Akt↑, mTOR↑, Risk↑, other↝,
8474- Mg,    Magnesium intake and colorectal tumor risk: a case-control study and meta-analysis
- Study, CRC, NA
Risk↓,
769- Mg,    Magnesium and cancer: more questions than answers
- Review, Var, NA
Risk↓,
770- Mg,    Magnesium and cancer: a dangerous liason
- Analysis, Var, NA
Risk↓,
776- Mg,    Magnesium intake is associated with a reduced risk of incident liver cancer, based on an analysis of the NIH-American Association of Retired Persons (NIH-AARP) Diet and Health Study prospective cohort
- Study, Liver, NA
Risk↓,
783- Mg,    Magnesium intake and incidence of pancreatic cancer: the VITamins and Lifestyle study
- Study, PC, NA
Risk↓,
784- Mg,    Direct and indirect associations between dietary magnesium intake and breast cancer risk
- Analysis, BC, NA
Risk↓, CRP↓,
785- Mg,    Magnesium: The overlooked electrolyte in blood cancers?
- Analysis, Var, NA
Risk↓,
786- Mg,  VitC,    A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer
- Review, Var, NA
Risk↓, *VitD↑, *pH↝, *ROS↓, TumCG↓, Synergy↑,
8673- MLT,    Therapeutic Potential of Melatonin in Gastrointestinal Cancers: Molecular Mechanisms, Preclinical Evidence and Clinical Implications
- Review, GC, NA
ChemoSen↑, TumVol↓, β-catenin/ZEB1↓, Risk↓, radioP↑, Mucositis↓, Dose↝, toxicity↓, BioAv↓, *antiOx↑, *SOD↑, *GPx↑, *Catalase↑, *NRF2↑, Apoptosis↑, Estro↝, Telomerase↓, *ROS↓, angioG↓, Imm↑, TumCCA↑, Glycolysis↓, OXPHOS↑, mTORC1↓, VEGF↓, Hif1a↓, ROS↓, TumAuto↓, HSP70/HSPA5↓, PI3K↓, Akt↓, mTOR↓, BAX↑, Casp↑, Cyt‑c↑, tumCV↓, TumCMig↓, TumCI↓, TumVol↓, TumW↓, P21↑, P53↑, Synergy↑, ER Stress↑, Synergy↑, RadioS↑, eff↑, eff↑, fatigue↓, Sleep↑,
7495- MLT,    Melatonin: a promising neuroprotective agent for cerebral ischemia-reperfusion injury
- Review, Stroke, NA
*other↓, *neuroP↑, *Stroke↓, *Dose↝, *Risk↓, *cognitive↑,
1779- MLT,    Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review
- Review, BC, NA
QoL↑, OS↑, Dose∅, antiOx↑, ROS↑, SOD↑, Catalase↑, GPx↑, Risk↓, NK cell↑, IL1β↓, IL6↓, TNF-α↓, radioP↑, chemoP↑, TumVol↓, TumMeta↓, angioG↓, ChemoSen↑, eff↑,
1786- MLT,    What is known about melatonin, chemotherapy and altered gene expression in breast cancer (Review)
- Review, BC, NA
AntiTum↑, Risk↓, ChemoSen↑,
4626- OLE,    A Comprehensive Review on the Anti-Cancer Effects of Oleuropein
- Review, Var, NA
Risk↓, Dose↑, TumCP↓, NF-kB↓, COX2/PTGS2↓, Akt↓, P53↑, BAX↑, Bcl-2↓, HIF-1↓, ROS↑, HO-1↑, chemoP↑, TumCCA↑, FASN↓,
4921- PEITC,    The Potential Use of Phenethyl Isothiocyanate for Cancer Prevention
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, HDAC↓, Risk↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4928- PEITC,    Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers
- vitro+vivo, Colon, SW-620
Risk↓, HDAC↓, TumW↓, TumCG↓, AP-1↓, cAMP↓, NF-kB↓, BMI1↓, SUZ12↓, EZH2↓, selectivity↑,
4931- PEITC,    Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Risk↓, miR-194↑, TumCI↓, MMP2↓, MMP9↓, BMP2↓, *chemoPv↑,
4938- PEITC,    Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers
- Trial, Nor, NA
*Risk↑, *P450↓, *BioAv↑, *BioAv↑, *BioAv↑, *Dose↝, Dose↝,
4939- PEITC,    Phenethyl Isothiocyanate Inhibits Angiogenesis In vitro and Ex vivo
- in-vitro, Pca, PC3 - ex-vivo, Nor, HUVECs
Risk↓, angioG↓, VEGF↓, TumCMig↓, Akt↓, EGF↓, TumCMig↓,
8094- QC,  KAE,    Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans
- Review, CardioV, NA
*Risk↓, *BP↓, *Dose?,
911- QC,  SFN,  Brocc,    Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) - study protocol for a randomized controlled trial
- Trial, PC, NA
TumCG↓, Risk↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
2142- Se,    A U-shaped association between selenium intake and cancer risk
- Review, Var, NA
Risk↝, Dose↝, Risk↓,
2141- Se,    Selenium and cancer risk: Wide-angled Mendelian randomization analysis
- Review, Var, NA
Dose↝, Risk↝,
2140- Se,    Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression
- Review, Var, NA
Risk↓, antiOx↑, eff↑, eff↝,
1704- Se,    Prospective study of toenail selenium levels and cancer among women
- Study, Var, NA
Risk∅,
1703- Se,    An Assessment of Serum Selenium Concentration in Women with Endometrial Cancer
- Study, EC, NA
Risk↓, selm↝,
1702- Se,    Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women
- Human, Ovarian, NA
Risk↓, eff∅,
1701- Se,    An Assessment of Serum Selenium Concentration in Women with Ovarian Cancer
- Human, Ovarian, NA
Risk↓, Risk↓, Dose∅,
1700- Se,    Metabolism of Selenium, Selenocysteine, and Selenoproteins in Ferroptosis in Solid Tumor Cancers
- Review, Var, NA
Dose↝, Risk↑, Dose↝, Risk↓,
1698- Se,    Association between Dietary Zinc and Selenium Intake, Oxidative Stress-Related Gene Polymorphism, and Colorectal Cancer Risk in Chinese Population - A Case-Control Study
- Human, CRC, NA
Risk↓,
1695- Se,    Serum Selenium Concentration as a Potential Diagnostic Marker for Early-Stage Colorectal Cancer: A Comparative Study
- Trial, CRC, NA
Risk↓, selm↑, Dose↓, antiOx↑, Dose↑, Dose↝,
1693- Se,    Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study
- Analysis, BC, NA
Risk↓, other∅,
1692- Se,    Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status
- Analysis, CRC, NA
Risk↓,
1691- Se,    The influence of selenium and selenoprotein gene variants on colorectal cancer risk
- Analysis, CRC, NA
Risk↓,
4485- Se,    Selenium stimulates the antitumour immunity: Insights to future research
- Review, Var, NA
*antiOx↑, chemoPv↑, ROS↑, Imm↑, selenoP↑, *IL2↑, *IL4↑, *TNF-α↓, *TGF-β↓, *EMT↓, Risk↓, *GPx↑, *TrxR↑,
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
4492- Se,    Selenium in cancer prevention: a review of the evidence and mechanism of action
- Review, Var, NA
Risk↓, AntiCan↑, *selenoP↑, TumMeta↓, *DNAdam↓, OS↑, *ROS↓,
4495- Se,    Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort
- Study, CRC, NA
Risk↓, Dose↝,
4496- Se,    Selenium status and survival from colorectal cancer in the European prospective investigation of cancer and nutrition
- Analysis, CRC, NA
Risk↝, OS↑,
4724- Se,    Chapter Four - Selenium in the Redox Regulation of the Nrf2 and the Wnt Pathway
- Review, Var, NA
Risk↓, *selenoP↑, other↝, Risk↓,
4744- Se,  Chemo,  antiOx,    Ingestion of selenium and other antioxidants during prostate cancer radiotherapy: A good thing?
- Review, Pca, NA
Risk↓, chemoP↑,
4711- Se,    Association of selenium status and blood glutathione concentrations in blacks and whites
- Human, Nor, NA
Risk↓, chemoP↑, *GSH↑,
4714- Se,  SSE,  SeNPs,    Selenium in cancer management: exploring the therapeutic potential
- Review, Var, NA
Risk↓, *BioAv↑, eff↝, *ROS↓, MMP↓, ROS↑, P53↑, *toxicity↓, TumCP↓, Casp↑, Apoptosis↑,
4722- Se,    The Yin and Yang of Nrf2-Regulated Selenoproteins in Carcinogenesis
- Review, Var, NA
Risk↓, *NRF2↓, NRF2↑, *NRF2↓, OS↑, eff↝, eff↝, NRF2↝,
4609- SeNPs,    Physiological Benefits of Novel Selenium Delivery via Nanoparticles
- Review, Var, NA - Review, IBD, NA - Review, Diabetic, NA
*selenoP↑, Risk↓, AntiCan↑, ROS↑, *Dose↝, *toxicity↓, *BioAv↑, *GutMicro↑, *other↓,
4603- SeNPs,    Therapeutic applications of selenium nanoparticles
- Review, Var, NA
AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, Synergy↑, *Synergy↑,
4491- SeNPs,  Chit,  VitC,    Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
- Study, Var, NA
*ROS↓, *selenoP↑, *antiOx↑, *Inflam↓, *Risk↓, *toxicity↓, AntiTum↑, Dose↝,

Showing Research Papers: 201 to 250 of 303
Prev Page 5 of 7 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 303

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 7,   ARE↑, 1,   Catalase↑, 2,   GPx↑, 1,   GSH↓, 3,   GSTs↑, 1,   GSTs↝, 1,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 2,   lipid-P↓, 2,   lipid-P↑, 1,   NRF2↓, 5,   NRF2↑, 2,   NRF2↝, 1,   PrxI↓, 1,   ROS↓, 9,   ROS↑, 31,   selenoP↑, 1,   SOD↑, 3,   SOD2↓, 1,   Trx↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

selm↑, 1,   selm↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   EGF↓, 1,   Insulin↓, 1,   mitResp↑, 1,   mtDam↑, 1,   OCR↓, 1,   OXPHOS↓, 1,   OXPHOS↑, 2,   OXPHOS↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 5,   ATP↓, 3,   Buty↑, 1,   cAMP↓, 1,   FASN↓, 2,   glucose↓, 2,   Glycolysis↓, 5,   Glycolysis↝, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   HMG-CoA↓, 3,   lactateProd↑, 1,   LDL↓, 2,   PKM2↓, 1,   SCFAs↑, 1,   SIRT1↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 33,   BAX↑, 12,   Bax:Bcl2↑, 1,   Bcl-2↓, 11,   BIM↑, 1,   Casp↑, 6,   Casp3↑, 10,   cl‑Casp3↑, 4,   pro‑Casp3↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 2,   Casp8↑, 2,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↑, 14,   DR5↑, 2,   FADD↑, 1,   Fas↑, 4,   FasL↑, 2,   Ferroptosis↑, 2,   iNOS↓, 3,   MDM2↓, 1,   MDM2↑, 1,   p‑MDM2↓, 1,   p38↑, 2,   PUMA↑, 1,   survivin↓, 4,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 1,   YAP/TEAD↓, 1,   YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ADCY4↑, 1,   Akt↓, 16,   Akt↑, 1,   p‑Akt↓, 4,   Akt2↓, 1,   cMET↓, 1,   EGFR↓, 4,   ERK↓, 3,   ERK↑, 3,   p‑ERK↓, 2,   HER2/EBBR2↓, 2,   IGFR↓, 1,   JAK1↓, 2,   JAK1↑, 1,   JNK↑, 2,   MAPK↓, 2,   MAPK↑, 1,   mTOR↓, 9,   mTOR↑, 2,   PI3K↓, 9,   PI3K↑, 1,   PKCδ↓, 1,   PTEN↑, 3,   RAS↓, 1,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↑, 2,   cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXM1↓, 2,   H3↓, 1,   HATs↑, 1,   HDAC↓, 7,   miR-194↑, 1,   miR-21↓, 1,   miR-590-3p↑, 1,   Myc↓, 1,   MYCN↓, 1,   other↓, 5,   other↑, 8,   other↝, 14,   other∅, 1,   SUZ12↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 1,   IRE1∅, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   NEU1↑, 1,   TumAuto↓, 2,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   BRCA1↓, 1,   BRCA2↓, 1,   DNAdam↑, 8,   DNArepair↑, 1,   hTERT/TERT↓, 1,   P53↑, 12,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 2,   cl‑PARP↑, 7,   PCNA↓, 4,   Telomerase↓, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 4,   CDK6↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 6,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycE/CCNE↑, 1,   GADD34↑, 2,   GADD45A↓, 1,   Ki-67↓, 6,   P21↓, 2,   P21↑, 7,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 3,   pRB↓, 1,   p‑RB1↓, 1,   cl‑RB1↓, 1,   TumCCA↓, 2,   TumCCA↑, 23,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMI1↓, 1,   BMP2↓, 1,   CSCs↓, 3,   EP300↓, 1,   GH↓, 1,   HH↝, 1,   HMGCR↓, 1,   IGF-1↓, 7,   IGFBP1↑, 1,   JAG1↑, 1,   Ki-67↓, 6,   mTORC1↓, 2,   NOTCH↓, 1,   NOTCH3↑, 1,   TumCG↓, 26,   TumCG↑, 1,   TumCP↓, 35,   TumCP↑, 1,   TumCP⇅, 1,   Wnt↓, 7,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 2,   Ca+2↓, 1,   Ca+2↑, 1,   Cdc42↓, 1,   E-cadherin↑, 1,   EMT↓, 4,   EMT↝, 1,   FAK↓, 2,   ITGB1↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   MMP2↓, 6,   MMP7↓, 1,   MMP9↓, 4,   MMPs↓, 5,   pax↓, 2,   PDGF↓, 2,   Rac1↓, 1,   Rho↓, 2,   serineP↓, 1,   Snail↓, 1,   TET1↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCA↓, 1,   TumCI↓, 11,   TumCI↑, 1,   TumCMig↓, 12,   TumCMig↑, 1,   TumMeta↓, 21,   UroPA↓, 1,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   ECM/TCF↓, 1,   HIF-1↓, 3,   Hif1a↓, 7,   VEGF↓, 10,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↑, 1,   GLUT1↓, 2,   GLUT2↓, 1,   MMP↓, 16,   MPT↑, 1,   TRPM7↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 13,   DR4↑, 3,   FOXP3↑, 1,   IL10↓, 1,   IL1β↓, 5,   IL2↑, 1,   IL6↓, 2,   Imm↑, 9,   INF-γ↑, 1,   Inflam↓, 11,   MCT1↓, 1,   Neut↑, 1,   NF-kB↓, 14,   NF-kB⇅, 1,   p‑NF-kB↓, 1,   NK cell↑, 4,   PD-L1↓, 1,   PGE2↓, 4,   PSA↓, 7,   SOCS-3↓, 1,   Th1 response↑, 1,   Th2↑, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AR↝, 1,   DHT↓, 1,   Estro↝, 1,   PPARα↓, 1,   PPARγ↑, 2,   SXR↑, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 3,   BioAv↑, 7,   BioAv↝, 1,   chemoR↓, 1,   ChemoSen↑, 40,   ChemoSen∅, 1,   CYP1A1↓, 1,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 2,   Dose↓, 4,   Dose↑, 7,   Dose⇅, 1,   Dose↝, 44,   Dose∅, 3,   eff↓, 4,   eff↑, 20,   eff↝, 11,   eff∅, 5,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   RadioS↑, 11,   selectivity↑, 16,   Synergy↑, 24,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↝, 1,   BloodF↓, 1,   BMD↑, 2,   BRCA1↓, 1,   CRP↓, 1,   EGFR↓, 4,   EZH2↓, 1,   FOXM1↓, 2,   Hcy/homoC↓, 2,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 2,   KRAS↓, 1,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 7,   SUZ12↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 24,   AntiCan∅, 2,   antiNeop↑, 1,   AntiTum↑, 7,   APG↓, 1,   cardioP↑, 3,   chemoP↑, 17,   chemoPv↑, 8,   ChemoSideEff↓, 4,   cognitive↑, 1,   fatigue↓, 1,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 2,   OS↓, 2,   OS↑, 16,   OS∅, 3,   Pain↓, 1,   PFS∅, 1,   QoL↑, 4,   radioP↑, 7,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 213,   Risk↑, 16,   Risk⇅, 3,   Risk↝, 7,   Risk∅, 18,   Sleep↑, 1,   toxicity↓, 9,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 7,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↓, 1,   GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 1,  
Total Targets: 387

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 7,   antiOx↑, 26,   Catalase↑, 6,   GPx↓, 1,   GPx↑, 10,   GPx1↑, 1,   GSH↑, 3,   GSR↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 2,   lipid-P↓, 7,   MDA↓, 4,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 6,   ROS↓, 36,   mt-ROS↓, 1,   SAM-e↑, 1,   selenoP↑, 10,   SOD↑, 9,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 2,   TrxR↑, 1,   TrxR1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   Acetyl-CoA↑, 1,   adiP↓, 1,   ALAT↓, 1,   AMPK↑, 5,   ATP↑, 2,   ATP↝, 1,   CRM↑, 2,   glucose↓, 4,   glucose↝, 1,   GlucoseCon↑, 1,   glyC↓, 1,   LDL↓, 9,   lipidLev↓, 1,   NAD↝, 1,   NADPH↑, 2,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↓, 1,   Casp3↑, 1,   Casp9↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   iNOS↑, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt2↓, 1,   IKKα↓, 1,   JNK↓, 1,   MAPK↓, 2,   mTOR↓, 2,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   other?, 3,   other↓, 8,   other↑, 12,   other↝, 18,  

Protein Folding & ER Stress(tgid=8) ⓘ

NQO2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 1,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   DNArepair↑, 1,   P53↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 9,   Ca+2↝, 1,   Cartilage↑, 2,   EMT↓, 1,   MLC2/MYL9↝, 1,   MMP-10↝, 1,   MMP9↓, 1,   MUC1↑, 1,   serineP↓, 1,   TGF-β↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 3,   TXA2↓, 1,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   BBB∅, 1,   CLDN1↑, 1,   CLDN3↑, 1,   IBI↑, 1,   MMP↑, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 7,   COX2/PTGS2↓, 5,   IFN-γ↓, 2,   IL1↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL4↑, 1,   IL6↓, 5,   Imm↑, 5,   Inflam↓, 38,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   NLRP3↓, 2,   NLRP3↑, 1,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 12,   VitD↑, 4,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↑, 3,   AChE↓, 2,   ADAM10↑, 1,   BDNF↑, 1,   BrainVol↑, 1,   BrainVol↝, 1,   BrainVol∅, 1,   GABA↓, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 2,   Aβ↓, 11,   Aβ↑, 1,   BACE/β-secretase↓, 2,   tau↓, 1,   p‑tau↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,   PPARα↑, 2,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 24,   BioAv⇅, 1,   BioAv↝, 4,   Dose?, 1,   Dose↓, 2,   Dose↑, 5,   Dose↝, 28,   eff↓, 5,   eff↑, 6,   eff↝, 3,   Half-Life↓, 3,   Half-Life↑, 2,   Half-Life↝, 5,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   BG↓, 1,   BMD↑, 4,   BP↓, 7,   Calcium↑, 2,   Calcium↝, 1,   CRP↓, 8,   Hcy/homoC↓, 3,   hs-CRP↓, 2,   IL6↓, 5,   Mag↑, 2,   TC↓, 1,   TG/TAG↓, 1,   TMAO↑, 3,   VitD↑, 4,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 3,   AntiDiabetic↑, 9,   AntiTum↓, 1,   BOLD↑, 1,   cardioP↑, 19,   chemoP↑, 3,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↓, 4,   cognitive↑, 41,   cognitive↝, 2,   cognitive∅, 1,   hepatoP↑, 5,   memory↑, 11,   Mood↑, 2,   motorD↓, 1,   motorD↑, 2,   neuroP↓, 1,   neuroP↑, 28,   Obesity↓, 4,   OS↑, 3,   Pain↓, 2,   QoL↑, 2,   radioP↑, 3,   Risk↓, 75,   Risk↑, 14,   Risk↝, 1,   Risk∅, 3,   Strength↑, 3,   Stroke↓, 5,   Stroke↑, 1,   toxicity↓, 14,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 7,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 3,   AntiViral↑, 3,   Bacteria↓, 1,   GutMicro↑, 18,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 3,   Ingr↝, 5,  
Total Targets: 236

Scientific Paper Hit Count for: Risk, Risk
23 Selenium
18 Folic Acid, Vit B9
16 Boron
15 Selenite (Sodium)
14 Lycopene
13 Aspirin
10 Vitamin D3
10 Magnesium
9 Choline
8 Vitamin B6,pyridoxine
7 Vitamin K2
7 Metformin
6 Allicin (mainly Garlic)
6 Lutein
6 Vitamin C (Ascorbic Acid)
6 diet Plant based
6 Exercise
6 Vitamin B12
6 Flaxseed/Linseed
6 Kaempferol
6 Phenethyl isothiocyanate
5 Chemotherapy
5 Hormone replacement therapy
5 Calcium
5 diet Fermented Foods
5 isoflavones
5 Selenium NanoParticles
4 beta-carotene(VitA)
4 Zeaxanthin
4 Capsaicin
4 Coenzyme Q10
4 Vitamin E
4 Sulforaphane (mainly Broccoli)
4 Melatonin
4 Vitamin B5,Pantothenic Acid
3 Aluminum
3 Radiotherapy/Radiation
3 Celecoxib
3 Chlorogenic acid
3 Chocolate
3 diet FMD Fasting Mimicking Diet
3 diet Short Term Fasting
3 Silicic Acid
3 iodine
3 Urolithin
2 5-Hydroxytryptophan
2 Anti-oxidants
2 Atorvastatin
2 Genistein (soy isoflavone)
2 Bruteridin(bergamot juice)
2 Butyrate
2 EGCG (Epigallocatechin Gallate)
2 flavonoids
2 Indole-3-carbinol
2 Inulin Prebiotic
2 phytic acid, Inositol hexakisphosphate
2 Potassium
2 Quercetin
2 chitosan
2 Taurine
2 Vitamin B1/Thiamine
1 Anthocyanins
1 alpha Linolenic acid
1 Astaxanthin
1 beta-glucans
1 Bifidobacterium
1 immunotherapy
1 selenomethionine
1 Bortezomib
1 Bullatacin
1 Carvacrol
1 Catechins
1 Chyawanprash
1 Diindolylmethane
1 Dipyridamole
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Vitamin A, Retinoic Acid
1 Fisetin
1 Fucoidan
1 Ginkgo biloba
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Graviola
1 Grapeseed extract
1 Inositol
1 isoquercitrin
1 Lactobacillus
1 Lecithin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Mung Bean Sprouts
1 Oleuropein
1 Broccoli
1 Rutin
1 buckwheat sprouts
1 Spermidine
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:785  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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