DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱
Source: HalifaxProj(prevent)
Type:
DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.
Scientific Papers found: Click to Expand⟱
5492- EP,    Nano-Pulse Stimulation Therapy in Oncology
- in-vivo, PC, Panc02 - in-vivo, BC, 4T1
CellMemb↑, Ca+2↑, DNAdam↑, eff↝, Imm↑,
5519- EP,    Nanosecond Pulsed Electric Fields (nsPEFs) for Precision Intracellular Oncotherapy: Recent Advances and Emerging Directions
- Review, Var, NA
MMP↓, Ca+2↑, eff↑, ER Stress↑, selectivity↑, CSCs↓, CD44↓, CD133↓, ROS↑, Imm↑, DNAdam↑, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp9↑, TumCD↑, Fas↑, UPR↑, Dose↝, Dose↝, Dose↓, Dose↑, HMGB1↓, eff↑, EPR↑, ChemoSen↑, ETC↝, *AntiAge↑, *Hif1a↑, *SIRT1↑,
5520- EP,    Nanosecond Pulsed Electric Field (nsPEF): Opening the Biotechnological Pandora’s Box
- Review, Var, NA
Ca+2↑, Apoptosis↑, Diff↑, TumCP↓, Wound Healing↑, CellMemb↑, VGCC↑, VGSC↑, DNAdam↑, selectivity↑,
6576- EU,    Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53
- in-vitro, HCC, HepG2
TumCD↑, selectivity↑, Apoptosis↓, ChrMod↑, DNAdam↑, P53↑, BAX↑, Bcl-2↓, Cyt‑c↑, eff↑, TumCCA↑,
6585- EU,    Anti-Tumor Activity of Eurycoma longifolia Root Extracts against K-562 Cell Line: In Vitro and In Vivo Study
- vitro+vivo, AML, K562
Dose↝, TumCG↓, Apoptosis↑, TumCCA↑, DNAdam↑, Akt↓, Bcl-2↓, PCNA↓,
6586- EU,    Unfermented Freeze-Dried Leaf Extract of Tongkat Ali (Eurycoma longifolia Jack.) Induced Cytotoxicity and Apoptosis in MDA-MB-231 and MCF-7 Breast Cancer Cell Lines
TumCD↑, DNAdam↑, TumCCA↑, Cyt‑c↑, Casp3↑,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *eff↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6330- Eug,    Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement
- Review, Var, NA
TumCD↑, TumCCA↑, AntiCan↑, Apoptosis↑, angioG↓, TumCI↓, TumMeta↓, ChemoSen↑, ALDH↓, NF-kB↓, IL6↓, IL8↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Snail↓, E-cadherin↑, SOX2↓, ROS↑, PCNA↓, MMP1↓, Cyt‑c↑, LDH↑, CSCs↓, OCT4↓, NOTCH1↓, EpCAM↓, CD44↓, HER2/EBBR2↓, VEGF↓, TIMP2↑, eff↑, Ca+2↑, TumVol↓, DNAdam↑, GSH↓, H2O2↑, lipid-P↑,
6871- FA,  Sesame,    Nano-encapsulated ferulic acid in sesame protein isolate alleviates acrylamide-induced liver toxicity and genotoxicity in rats via oxidative stress and DNA damage modulation
- in-vivo, Nor, NA
*GSH↑, *GPx↑, *SOD↓, *Catalase↑, *MDA↓, *IL6↓, *TNF-α↑, *DNAdam↓, *hepatoP↑, *BioAv↓, *BioAv↑,
6877- FA,    The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *hepatoP↑, *DNAdam↓, *Sepsis↓, *MDA↓, *GSH↑, *GPx↑, *ROS↓,
7518- FA,  Rad,    Radiosensitizing effect of ferulic acid on human cervical carcinoma cells in vitro
- in-vitro, Cerv, HeLa - in-vitro, Cerv, ME-180
lipid-P↑, ROS↑, DNAdam↑, RadioS↑,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
2846- FIS,    Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity
- in-vitro, Nor, NA
*cardioP↑, *ROS↓, *Casp↓, *DNAdam↓,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, eff↑, ChemoSen↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2826- FIS,    Fisetin induces apoptosis in breast cancer MDA-MB-453 cells through degradation of HER2/neu and via the PI3K/Akt pathway
- in-vitro, BC, MDA-MB-453
Apoptosis↑, p‑ENO1↓, DNAdam↑, PI3K↑, p‑Akt↑, HER2/EBBR2↓,
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
2842- FIS,    Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cells
- in-vitro, GC, AGS
TumCCA↑, CDK2↓, P53↑, selectivity↑, MMP↓, DNAdam↑, cl‑PARP↑, mt-ROS↑, eff↓, survivin↓,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2/PTGS2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
6901- FIS,    Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
- in-vivo, HNSCC, CAL33
TumCG↓, TumCD↑, selectivity↑, TumCCA↑, CDC25↓, CDK1↓, CycB/CCNB1↓, P53↑, DNAdam↑, Apoptosis↑, γH2AX↑, cl‑PARP↑, other↝, JNK↑, PI3K↓, Akt↓, ERK↓, EGFR↓, STAT3↓, TumAuto↑, Dose↝, TumVol↓, Ki-67↓, cl‑Casp3↑, P21↓, p27/CDKN1B↓,
6900- FIS,    Fisetin targets phosphatidylinositol-3-kinase and induces apoptosis of human B lymphoma Raji cells
- in-vitro, lymphoma, NA
PI3K↓, Apoptosis↑, IAP2/BIRC3↓, mTOR↓, γH2AX↑, DNAdam↑,
6976- Form,    Study on the Mechanism of Formononetin Against Hepatocellular Carcinoma: Regulating Metabolic Pathways of Ferroptosis and Cell Cycle
- vitro+vivo, HCC, HepG2
ROS↑, DNAdam↑, TumCCA↑, CHK1↝, CDC25↝, CDK1↝, CycB/CCNB1↝, GSH↓, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, P53↓, GPx4↓, other↝, TumCP↓, γH2AX↑, TumCG↓, Ki-67↓, PCNA↓, MMP↓,
7011- Fuc,  ATO,  VitA,RetA,    Fucoidan enhances the therapeutic potential of arsenic trioxide and all-trans retinoic acid in acute promyelocytic leukemia, in vitro and in vivo
- NA, APL, APL NB4 - vitro+vivo, NA, NA
TumCCA↑, DNAdam↑, TumCP↓, Apoptosis↑, Diff↑, CD11b↑, eff↑, Dose↝,
7012- Fuc,    Fucoidan: A promising natural therapeutic agent for protecting human kidney health
- Review, EC, NA
*RenoP↑, *Inflam↓, *antiOx↑, *ROS↓, *BloodF↑, *diuretic↑, *BioAv↓, *BioAv↑, *MAPK↓, *ERK↑, *NLRP3↓, *NRF2↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *lipid-P↓, *DNAdam↓, *Fibrosis↓, *JAK2↓, *STAT3↓, *uricA↓, *COL1↓, *α-SMA↓, *SIRT1↑, *HO-1↑, *GLP-1R↑, *HMGB1↓, *RAGE↓, *NF-kB↓, *TGF-β1↓, *PI3K↓, *Akt↓, *GutMicro↑, *SCFAs↑, *Buty↑, *IBI↑, *TJ↑, *Dose↝,
1086- GA,    Anti-leukemic effects of gallic acid on human leukemia K562 cells: downregulation of COX-2, inhibition of BCR/ABL kinase and NF-κB inactivation
- in-vitro, AML, K562
tumCV↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Cyt‑c↑, cl‑PARP↓, DNAdam↑, Casp3↑, FASN↓, Casp8↑,
1065- GA,    Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression
- vitro+vivo, Pca, NA
tumCV↓, MMP↓, DNAdam↑, HDAC1↓, HDAC2↓, PCNA↓, cycD1/CCND1↓, cycE1↓, P21↑, TumVol↓,
7037- GA,  Chit,    Gallic acid-loaded chitosan nanoparticles enhance the DNA damage and apoptotic features through inhibiting flap endonuclease-1 in triple-negative breast cancer cells
- in-vitro, BC, MDA-MB-231
DNAdam↑, Apoptosis↑, FEN1↓, selectivity↑, ROS↑, DNAdam↑, PARP1↑, TumCP↓, p‑PI3K↓, Akt↓, cycD1/CCND1↓, BAX↑, Casp3↑,
7048- GA,    Natural bioactive gallic acid shows potential anticancer effects by inhibiting the proliferation and invasiveness behavior in human embryonic carcinoma cells
- in-vitro, Var, NA
AntiCan↑, TumCCA↑, angioG↓, TumCMig↓, TumMeta↓, CSCs↓, Apoptosis↑, P21↑, P53↑, p27/CDKN1B↑, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, SOX2↓, Nanog↓, OCT4↓, ROS↑, DNAdam↑, BRCA1↑, ATM↑, CHK1↑, Chk2↑, Histones↑, TumCI↓, MMPs↓, EGFR↓, JAK2↓, STAT5↓,
7033- GA,  OL,    Gallic Acid Enhances Olaparib-Induced Cell Death and Attenuates Olaparib Resistance in Human Osteosarcoma U2OS Cell Line
- in-vitro, OS, U2OS
tumCV↓, angioG↓, DNAdam↑, Apoptosis↑, cl‑PARP↓, Bcl-2↓, BAX↑, ROS↓, eff↑, TumCMig↓, VEGF↓, Casp9↑, P53↑, selectivity↑,
5205- Gallo,    Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
- in-vitro, Endo, ISH
LDH↓, TumCG↓, LDHA↓, Apoptosis↑, cl‑Casp3↑, Mcl-1↓, Bcl-2↓, TumCCA↑, ROS↑, mt-DNAdam↑, GlucoseCon↓, ATP↓, PDH↑, Pyruv↑, Glycolysis↓, TCA↑, cMyc↓, E-cadherin↑, Slug↓,
7064- GamB,    Gambogic acid inhibits the catalytic activity of human topoisomerase IIα by binding to its ATPase domain
- in-vitro, GC, SGC-7901 - in-vitro, Liver, Bel-7402 - in-vitro, HCC, SMMC-7721 cell - in-vitro, Ovarian, HO-8910
TOP2↓, DNAdam↑, MDR1↓,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
7087- GAR,    Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential
- Review, Var, NA
HATs↓, p300↓, CBP↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, Inflam↓, angioG↓, TumCP↓, TumMeta↓, TumCCA↑, EMT↓, CSCs↓, P53↑, TrxR↓, ROS↑, JNK↑, DNAdam↑, mt-Apoptosis↑, ER Stress↑, CHOP/DDIT3↑, DDIT4↑, TRIB3↑, SESN2↑, miR-218↑, eff↑, ChemoSen↑, BioAv↓, Half-Life↓, BioAv↑,
7090- GAR,    Garcinol
AChE↓, BChE↓, *Inflam↓, *5LO↓, *PGE2↓, *antiOx↑, FAK↓, DNAdam↑, MMP↓, Casp↑, NF-kB↓, HATs↓, *toxicity↓,
831- GAR,  CUR,    Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, Casp3↑, MMP↓, Cyt‑c↑, proCasp9↑, Bcl-2↓, BAX↑, PARP↓, DNAdam↑, DFF45↓,
797- GAR,  CUR,    Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
- in-vitro, BC, MCF7 - in-vitro, OS, U2OS - in-vitro, OS, SaOS2
TumCP↓, H3K18↓, DNAdam↑,
7119- GEO2,    Germanium oxide enhances the radiosensitivity of cells
- in-vitro, Nor, CHO K1
RadioS↑, ROS↑, eff↓, DNAdam↓, Catalase∅, GSTs∅,
6565- Ger,    Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest
- in-vitro, CRC, COLO205
AntiCan↑, mt-Apoptosis↑, BAX↑, Bcl-2↓, DNAdam↑, TumCCA↑,
6569- Ger,    Geraniol inhibits cell growth and promotes caspase-dependent apoptosis in nasopharyngeal cancer C666-1 cells via inhibiting PI3K/Akt/mTOR signaling pathway
- in-vitro, NPC, C666-1
tumCV↓, MMP↓, Apoptosis↑, TBARS↑, GSH↓, SOD↓, BAX↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, mTOR↓, DNAdam↑, ROS↑,
7253- Gink,    Ginkgetin Alleviates Inflammation and Senescence by Targeting STING
*cGAS–STING↓, *Inflam↓, *antiOx↑, *AntiAge↑, *DNAdam↓, *cellSen↓,
4513- GLA,    Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines
- in-vitro, Liver, HUH7
TumCP↓, ROS↑, Apoptosis↑, HO-1↑, Trx↑, lipid-P↑, eff↓, MMP↓, DNAdam↑, selectivity↑,
4511- GLA,    Gamma-Linolenic Acid (GLA) Protects against Ionizing Radiation-Induced Damage: An In Vitro and In Vivo Study
- vitro+vivo, Nor, RAW264.7
*radioP↑, *ROS↓, *DNAdam↓, *IL6↓, *TNF-α↓, *IL10↓, *NF-kB↓, *SOD↑, *Catalase↑, *GSH↑,
7332- GSE,    The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials
- Review, Nor, NA
*BP↓, *eff↑, *ROS↓, *DNAdam↓, *cardioP↑, *eff↝,
7330- GSE,    Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
- Review, Var, NA
*BioAv↑, *ROS↓, AntiCan↑, selectivity↑, RenoP↑, *hepatoP↑, *DNAdam↓, *Stroke↓, *Bcl-2↑, cMyc↓,
7487- H2,    A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives
- Review, Nor, NA
*Inflam↓, *antiOx↓, *Stress↓, *Dose↝, *cardioP↑, *GastroP↑, *BBB↑, *eff↑, *toxicity↓, *Dose↝, *hepatoP↑, *ROS↓, *SOD↑, *TBARS↓, *HDL↑, *LDL↓, *Obesity↓, *GSH↑, *TNF-α↓, *GutMicro↑, *DNAdam↓, *γH2AX↓, *p‑p38↓, *NF-kB↓,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓,
292- HCA,    Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway
- in-vitro, AML, K562
ACLY↓, TumCG↓, AMPK↑, mTOR↑, UPR↑, eIF2α↑, ATF4↑, TumCCA↑, DNAdam↑,

Showing Research Papers: 201 to 250 of 402
Prev Page 5 of 9 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 402

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

DDIT4↑, 1,   FEN1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Catalase∅, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 3,   GSTs↓, 1,   GSTs∅, 1,   H2O2↑, 1,   HO-1↑, 3,   lipid-P↓, 1,   lipid-P↑, 5,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 5,   ROS↑, 22,   mt-ROS↑, 1,   SOD↓, 2,   TBARS↑, 1,   Thiols↓, 1,   Trx↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   CDC2↓, 2,   CDC25↓, 4,   CDC25↝, 1,   EGF↓, 2,   ETC↝, 1,   FGFR1↓, 2,   MEK↓, 1,   MMP↓, 16,   mtDam↑, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 2,   ACLY↓, 1,   ALAT↓, 1,   AMPK↑, 5,   cMyc↓, 3,   p‑ENO1↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   Histones↑, 1,   LDH↓, 1,   LDH↑, 1,   LDHA↓, 1,   PDH↑, 1,   PDK1↓, 1,   Pyruv↑, 1,   SIRT1↓, 1,   TCA↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 15,   p‑Akt↑, 1,   APAF1↑, 2,   Apoptosis↓, 2,   Apoptosis↑, 20,   mt-Apoptosis↑, 2,   BAD↓, 1,   BAD↑, 3,   Bak↑, 1,   BAX↓, 1,   BAX↑, 12,   Bax:Bcl2↑, 2,   Bcl-2↓, 15,   Bcl-xL↓, 2,   BID↑, 1,   BIM↑, 3,   Casp↑, 4,   Casp3↑, 15,   cl‑Casp3↑, 4,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 10,   cl‑Casp9↑, 2,   proCasp9↑, 1,   CBP↓, 1,   Chk2↑, 1,   CK2↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 13,   Diablo↑, 4,   DR5↑, 1,   FADD↑, 1,   Fas↓, 1,   Fas↑, 3,   FasL↑, 1,   Ferroptosis↑, 1,   IAP2/BIRC3↓, 1,   JNK↑, 3,   MAPK↓, 5,   Mcl-1↓, 4,   MDM2↓, 1,   MOMP↑, 1,   Myc↓, 1,   NOXA↑, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 5,   p38↓, 2,   PUMA↑, 1,   survivin↓, 4,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↑, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

H3K18↓, 1,   HER2/EBBR2↓, 4,   p70S6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 1,   cJun↓, 5,   HATs↓, 2,   miR-218↑, 1,   other↝, 2,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP27↓, 2,   HSP70/HSPA5↓, 3,   HSP90↓, 1,   IRE1↑, 3,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↓, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   SESN2↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↑, 1,   CHK1↑, 1,   CHK1↝, 1,   DFF45↓, 1,   DNAdam↓, 1,   DNAdam↑, 38,   mt-DNAdam↑, 1,   P53↓, 1,   P53↑, 14,   PARP↓, 1,   PARP↑, 2,   cl‑PARP↓, 2,   cl‑PARP↑, 10,   PARP1↑, 1,   PCNA↓, 4,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↝, 1,   CDK2↓, 9,   CDK4↓, 9,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 11,   cycE/CCNE↓, 5,   cycE1↓, 1,   E2Fs↓, 1,   P21↓, 1,   P21↑, 9,   Securin↓, 1,   TumCCA↓, 1,   TumCCA↑, 24,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD133↓, 2,   CD44↓, 4,   cFos↓, 6,   CSCs↓, 6,   Diff↑, 2,   EMT↓, 9,   EpCAM↓, 2,   ERK↓, 3,   p‑ERK↓, 1,   FGF↓, 1,   FGFR2↓, 1,   FOXO3↝, 1,   HDAC1↓, 1,   HDAC2↓, 1,   mTOR↓, 11,   mTOR↑, 1,   mTORC1↓, 2,   mTORC2↓, 1,   Nanog↓, 1,   NOTCH1↓, 2,   OCT4↓, 3,   p300↓, 1,   PI3K↓, 11,   PI3K↑, 1,   p‑PI3K↓, 1,   PTEN↑, 2,   SOX2↓, 2,   STAT3↓, 3,   p‑STAT3↓, 1,   STAT5↓, 1,   TCF↑, 1,   TCF-4↓, 2,   TOP1↓, 1,   TOP2↓, 2,   TumCG↓, 8,   tyrosinase↓, 1,   VGCC↑, 1,   VGSC↑, 1,   Wnt↓, 6,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   Ca+2↑, 5,   CD11b↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 6,   FAK↓, 1,   Fibronectin↓, 2,   Ki-67↓, 2,   MET↓, 1,   MMP1↓, 2,   MMP2↓, 8,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 8,   MMPs↓, 2,   N-cadherin↓, 4,   PDGF↓, 1,   PKCδ↓, 1,   RECK↑, 1,   Slug↓, 2,   Snail↓, 4,   TET1↓, 1,   TGF-β↓, 1,   TIMP1↑, 2,   TIMP2↑, 2,   TRIB3↑, 1,   TumCA↓, 1,   TumCI↓, 5,   TumCMig↓, 4,   TumCP↓, 9,   TumMeta↓, 8,   Twist↓, 2,   uPA↓, 6,   VEGFR1↓, 1,   Vim↓, 5,   Zeb1↓, 2,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   ATF4↓, 1,   ATF4↑, 4,   EGFR↓, 6,   eNOS↓, 1,   EPR↑, 1,   NO↑, 1,   VEGF↓, 7,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 2,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 7,   HMGB1↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 2,   JAK2↓, 1,   NF-kB↓, 13,   NF-kB↑, 1,   p65↓, 1,   PGE2↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   ChemoSen↑, 10,   Dose↓, 1,   Dose↑, 1,   Dose↝, 6,   eff↓, 4,   eff↑, 15,   eff↝, 1,   Half-Life↓, 2,   Half-Life↝, 1,   MDR1↓, 1,   RadioS↑, 6,   selectivity↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AR↓, 1,   AST↓, 1,   BRCA1↑, 1,   EGFR↓, 6,   HER2/EBBR2↓, 4,   IL6↓, 1,   Ki-67↓, 2,   LDH↓, 1,   LDH↑, 1,   Myc↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   antiNeop↑, 1,   chemoP↑, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   TumVol↓, 4,   TumW↓, 1,   Wound Healing↑, 1,  
Total Targets: 305

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   Buty↑, 1,   diuretic↑, 1,   GLP-1R↑, 1,   SCFAs↑, 1,   SpO2↑, 1,   Stress↓, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 7,   Catalase↑, 6,   Fenton↓, 1,   GPx↑, 4,   GSH↑, 5,   GSTs↑, 2,   HDL↑, 1,   HO-1↑, 3,   lipid-P↓, 3,   MDA↓, 4,   MPO↓, 1,   NOX4↓, 1,   NRF2↑, 4,   RNS↓, 2,   ROS↓, 10,   SOD↓, 2,   SOD↑, 5,   TBARS↓, 2,   uricA↓, 1,   VitE↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑cMyc↑, 1,   LDL↓, 1,   NADPH↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 1,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp↓, 1,   Casp3↓, 1,   Casp9↓, 1,   iNOS↓, 1,   MAPK↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 11,   γH2AX↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 2,   PI3K↓, 1,   PI3K↑, 1,   STAT3↓, 1,   STAT3↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   COL1↓, 1,   Fibrosis↓, 1,   RAGE↓, 1,   TGF-β1↓, 1,   TJ↑, 1,   Treg lymp↝, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   cellSen↓, 1,   COX2/PTGS2↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 1,   IL4↑, 1,   IL6↓, 4,   Inflam↓, 8,   JAK2↓, 1,   JAK2↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 4,   PGE2↓, 2,   TNF-α↓, 4,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

cGAS–STING↓, 1,   NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 4,   Dose↓, 1,   Dose↑, 1,   Dose↝, 4,   eff↑, 4,   eff↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   BP↓, 1,   GutMicro↑, 2,   IL6↓, 4,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↑, 1,   cardioP↑, 4,   hepatoP↑, 4,   neuroP↑, 3,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 2,   toxicity↝, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 118

Scientific Paper Hit Count for: DNAdam, DNA damage
31 Silver-NanoParticles
18 Radiotherapy/Radiation
17 Vitamin C (Ascorbic Acid)
12 Magnetic Fields
12 Curcumin
11 Fisetin
7 Chemotherapy
7 Cisplatin
7 Ashwagandha(Withaferin A)
7 Chrysin
7 Quercetin
7 Lycopene
7 salinomycin
7 Selenium NanoParticles
6 Artemisinin
6 Apigenin (mainly Parsley)
6 Berberine
6 Carvacrol
6 Emodin
6 Piperlongumine
6 Sulforaphane (mainly Broccoli)
5 Copper and Cu NanoParticles
5 Allicin (mainly Garlic)
5 Baicalein
5 Betulinic acid
5 Ellagic acid
5 diet FMD Fasting Mimicking Diet
5 Dandelion Root
5 Gallic acid
5 nicotinamide adenine dinucleotide
5 Selenite (Sodium)
5 Thymoquinone
4 Auranofin
4 doxorubicin
4 Beta-Caryophyllene
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Echinacea
4 Electrical Pulses
4 Ferulic acid
4 Garcinol
4 Magnetic Field Rotating
4 Vitamin B3,Niacin
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
3 chitosan
3 Anethole/trans-Anethole
3 borneol
3 Boron
3 Boswellia (frankincense)
3 Rosmarinic acid
3 Cat’s Claw
3 Cynaropicrin
3 Disulfiram
3 EGCG (Epigallocatechin Gallate)
3 Eurycomanone
3 Eugenol
3 Hibiscus sabdariffa
3 Magnolol
3 Nimbolide
3 Phenethyl isothiocyanate
3 α-Santalol/Sandalwood oil
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Vitamin K2
2 1,8-Cineole
2 Moringa oleifera
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Metformin
2 Melatonin
2 Astaxanthin
2 Aloe anthraquinones
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Crocetin
2 diet Short Term Fasting
2 Fucoidan
2 Gambogic Acid
2 Geraniol
2 γ-linolenic acid (Borage Oil)
2 Grapeseed extract
2 Hydrogen Gas
2 Hydroxycinnamic-acid
2 isoorientin
2 Juglone
2 Propyl gallate
2 Ursolic acid
2 VitK3,menadione
1 3-bromopyruvate
1 5-Hydroxytryptophan
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Fennel Oil/Foeniculum vulgare
1 Ascorbyl Palmitate
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 Zinc
1 carboplatin
1 Catechins
1 chaetocin
1 Chlorophyllin
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Dichloroacetate
1 Deguelin
1 Diclofenac
1 Date Fruit Extract
1 D-limonene
1 immunotherapy
1 Butyrate
1 Sesame seeds and Oil
1 Formononetin
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 olaparib/LYNPARZA
1 Galloflavin
1 Germanium inorganic
1 Ginkgetin
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Honokiol
1 Hyperthermia
1 HydroxyTyrosol
1 Isobavachalcone
1 isoquercitrin
1 Licorice
1 Luteolin
1 Methyl salicylate / Sweet Birch oil
1 Piperine
1 Plumbagin
1 Rauwolfia serpentina/Indian Snakeroot
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 temozolomide
1 triptolide
1 Urolithin
1 Iron
1 Magnesium
1 Vitexin
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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