E-cadherin Cancer Research Results

E-cadherin, E-cadherin: Click to Expand ⟱
Source: HalifaxProj(restore)
Type:
Also known as Cadherin1 (CDH1)
E-cadherin, is a type of cell adhesion molecule that plays a crucial role in maintaining tissue structure and cell-cell interactions. In the context of cancer, E-cadherin has been found to be a tumor suppressor gene.

E-cadherin is a transmembrane protein that mediates cell-cell adhesion through its extracellular domain, which interacts with other E-cadherin molecules on adjacent cells. This interaction helps to maintain tissue integrity and prevent cancer cells from invading surrounding tissues.

In many types of cancer, including breast, colon, and prostate cancer, E-cadherin expression is often reduced or lost.
cell adhesion molecules spanning four families of 1) Integrins (α2β1, α5/β1, αL/β2); 2) Cadherins (E-cad, P-cad, N-cad); 3) Ig-CAMs (VCAM, NCAM, ICAM, Nectins, Necl); and 4) Selectins (E-selectin, P-selectin, L-selectin).
Scientific Papers found: Click to Expand⟱
878- RES,    Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression
- vitro+vivo, CRC, LoVo
TumMeta↓, E-cadherin↑, Vim↓, TGF-β↓, SMAD2↓, EMT↓, SMAD3↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,
3078- RES,    The Effects of Resveratrol on Prostate Cancer through Targeting the Tumor Microenvironment
- Review, Pca, NA
*ROS↓, ROS↑, DNAdam↑, Apoptosis↑, Hif1a↑, Casp3↑, Casp9↑, Cyt‑c↑, Dose↝, MMPs↓, MMP2↓, MMP9↓, EMT↓, E-cadherin↑, N-cadherin↓, AR↓,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2/PTGS2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3098- RES,    Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers
- Review, Var, NA
NOTCH2↓, Wnt↓, β-catenin/ZEB1↓, p‑SMAD2↓, p‑SMAD3↓, PTCH1↓, Smo↓, Gli1↓, E-cadherin↑, NOTCH⇅, TAC?, NKG2D↑, DR4↑, survivin↓, DR5↑, BAX↑, p27/CDKN1B↑, cycD1/CCND1↓, Bcl-2↓, STAT3↓, STAT5↓, JAK↓, DNAdam↑, γH2AX↑,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
1745- RosA,    Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
- Review, Var, NA - Review, AD, NA
ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2/PTGS2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,
3025- RosA,    Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota
- in-vivo, IBD, NA
*GutMicro↑, *ROCK1↓, *Rho↓, *CaMKII ↓, *Zeb1↓, *ZO-1↓, *E-cadherin↓, *IL1β↓, *IL6↓, *TNF-α↓, *GRP78/BiP↓, *PERK↓, *IRE1↓, *ATF6↓, *CHOP/DDIT3↓, *Casp12↓, *Casp9↓, *BAX↓, *Casp3↓, *Cyt‑c↓, *RIP1↓, *MLKL↓, *IL10↑, *Bcl-2↑, *ER Stress↓,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
1132- RT,    Rutin Promotes Proliferation and Orchestrates Epithelial–Mesenchymal Transition and Angiogenesis in MCF-7 and MDA-MB-231 Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
Vim↑, N-cadherin↑, E-cadherin↓, TumCP↑, TumCMig↑, tumCV↑, MKI67↑,
5127- Sal,    Salinomycin repressed the epithelial–mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway
- in-vitro, Ovarian, NA
TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Wnt↓, β-catenin/ZEB1↓, TumCP↓, TumCMig↓, EMT↓,
1135- Selenate,    Selenate induces epithelial-mesenchymal transition in a colorectal carcinoma cell line by AKT activation
- in-vitro, CRC, DLD1
EMT↑, Akt↑, Twist↑, Vim↑, E-cadherin↓,
9277- SES, SSM,    Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinoma
- vitro+vivo, Gall, SGC996
AntiCan↑, CSCs↓, NF-kB↓, IL5↓, p‑STAT3↓, Twist↓, Vim↓, E-cadherin↑, Dose↝,
3198- SFN,    Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells
- in-vitro, Pca, NA
Nanog↓, SOX2↓, E-cadherin↓, Snail↓, VEGFR2/KDR/Flk1↓, Diff↓, TumCMig↓, EMT↓, CXCR4↓, NOTCH1↓, ALDH1A1↓, CSCs↓, Synergy↑,
1136- SFN,    Sulforaphane inhibits epithelial-mesenchymal transition by activating extracellular signal-regulated kinase 5 in lung cancer cells
- in-vitro, Lung, NA - in-vivo, NA, NA
TumCMig↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Snail↓, ERK5↑, EMT↓,
110- SFN,    Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
- in-vivo, PC, NA
HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, VEGF↓, PDGFRA↓, EMT↓, Zeb1↓, Bcl-2↓, XIAP↓, E-cadherin↑, OCT4↓, Nanog↓, TumCG↑,
1462- SFN,    Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
EMT↓, TumCI↓, TumCMig↓, E-cadherin↑, Zeb1↓, Snail↓, COX2/PTGS2↝, MMP2↝, MMP9↝,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3296- SIL,    Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway
- in-vitro, Oral, Ca9-22 - in-vivo, Oral, YD10B
TumCP↓, TumCCA↑, ROS↑, SOD1↓, SOD2↓, *JNK↑, toxicity?, TumCMig↓, TumCI↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, P53↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, SOD↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3322- SIL,    Therapeutic intervention of silymarin on the migration of non-small cell lung cancer cells is associated with the axis of multiple molecular targets including class 1 HDACs, ZEB1 expression, and restoration of miR-203 and E-cadherin expression
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460
HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, HATs↑, Zeb1↓, E-cadherin↑, TumCMig↓,
2357- SK,    GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism
- Study, HCC, NA - in-vivo, NA, NA
AntiTum↑, GTPBP4↓, PKM2↓, lactateProd↓, GlucoseCon↓, Glycolysis↓, E-cadherin↑, TumCG↓,
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
5080- SSE,    Sodium Selenite Regulates the Proliferation and Apoptosis of Gastric Cancer Cells by Suppressing the Expression of LncRNA HOXB-AS1
- in-vitro, GC, HGC27 - in-vitro, GC, NCI-N87
AntiTum↑, HOXB-AS1↓, TumCP↓, TumCI↓, Apoptosis↑, BAD↓, Bcl-2↓, cl‑Casp3↑, MMP2↓, E-cadherin↑, N-cadherin↓, ROS↑, NF-kB↓,
5075- SSE,    Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma
- vitro+vivo, RCC, 786-O
TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, NF-kB↓, eff↓, E-cadherin↑, cl‑Casp3↑, VEGF↓, MMP9↓, EMT↓, MMP↓, mtDam↑, BAX↑, Bcl-2↓,
1575- statins,  Citrate,    Inhibition of Lung Cancer Growth: ATP Citrate Lyase Knockdown and Statin Treatment Leads to Dual Blockade of Mitogen-Activated Protein Kinase (MAPK) and Phosphatidylinositol-3-Kinase (PI3K)/AKT Pathways
- in-vitro, NSCLC, A549
Synergy↑, HMG-CoA↓, eff↑, AntiTum↑, EGFR↓, eff↑, ROS↑, EMT↓, E-cadherin↑, MUC1↑, p‑ACLY↓, p‑Akt↓, eff↑,
6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,
1137- Taur,    Taurine Attenuates Epithelial-Mesenchymal Transition-Related Genes in Human Prostate Cancer Cells
- in-vitro, Pca, NA
N-cadherin↓, Twist↓, Zeb1↓, Snail↓, Vim↓, E-cadherin↑,
1138- TQ,    Thymoquinone inhibits epithelial-mesenchymal transition in prostate cancer cells by negatively regulating the TGF-β/Smad2/3 signaling pathway
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumMeta↓, EMT↓, E-cadherin↑, Vim↓, Slug↓, TGF-β↓, SMAD2↓, SMAD3↓,
1935- TQ,    Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
- Review, OS, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, ROS↑, P53↑, Twist↓, E-cadherin↑, N-cadherin↓, NF-kB↓, IL8↓, XIAP↓, Bcl-2↓, STAT3↓, MAPK↓, PI3K↓, Akt↓, ERK↓, MMP2↓, MMP9↓, *ROS↓, HO-1↑, selectivity↑, TumCG↓,
3411- TQ,    Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
- Review, Var, NA
p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3431- TQ,    PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Glycolysis↓, Warburg↓, HK2↓, ATP↓, NADPH↓, PI3K↓, Akt↓, TumCP↓, E-cadherin↑, N-cadherin↓, Hif1a↓, PKM2↓, GlucoseCon↓, lactateProd↓, EMT↓,
1139- UA,    Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells
- in-vitro, Lung, A549
TumMeta↓, AEG1↓, E-cadherin↑, N-cadherin↓, Vim↓, EMT↓,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4838- Uro,    The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
- Review, Var, NA
BioAv↑, Inflam↓, IL6↓, IL1β↓, NOS2↓, p53 Wildtype↑, MDM2↑, Snail↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓, mTOR↓, p‑Akt↓, selectivity↑, EMT↓,
4844- Uro,    Urolithin A Inhibits Epithelial–Mesenchymal Transition in Lung Cancer Cells via P53-Mdm2-Snail Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H460
TumCMig↓, TumCI↓, EMT↓, Snail↓, MDM2↑, P53↑, E-cadherin↑, N-cadherin↓, Vim↓,
1217- VitC,    High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
- in-vitro, BC, Bcap37 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCMig↓, E-cadherin↑, Vim↓, EMT↓,
1740- VitD3,    Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms
- Review, Var, NA
Risk↓, eff↑, eff↑, Risk↓, Risk↓, ChemoSen↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp9↑, hTERT/TERT↓, Synergy↑, E-cadherin↑, CLDN2↑, ZO-1↑, Snail↓, Zeb1↓, Vim↓, VEGF↓, NK cell↑, Risk↓, eff↑,
2366- VitD3,    Vitamin D3 decreases glycolysis and invasiveness, and increases cellular stiffness in breast cancer cells
- in-vitro, BC, MCF7
Glycolysis↓, tumCV↓, Apoptosis↑, mTOR↓, AMPK↑, EMT↓, E-cadherin↑, F-actin↑, Vim↓,
1820- VitK3,    Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,
1821- VitK3,    Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration
- in-vitro, Oral, NA - in-vitro, Nor, HEK293 - in-vitro, Nor, HaCaT
selectivity↑, TumCD↓, BAX↑, P53↑, Bcl-2↓, p65↓, E-cadherin↑, EMT↓, Vim↓, Fibronectin↓, TumCG↓, TumCMig↓,

Showing Research Papers: 201 to 248 of 248
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 248

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ARE↑, 1,   Catalase↓, 5,   Catalase↑, 1,   Copper↑, 1,   ENOX2↓, 1,   GPx↓, 3,   GPx4↓, 4,   GSH↓, 12,   GSH↑, 2,   GSR↓, 1,   GSTs↓, 2,   GSTs↑, 2,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 8,   Iron↑, 1,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 1,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 9,   NRF2↑, 7,   p‑NRF2↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 12,   ROS↑, 85,   ROS⇅, 3,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 3,   SOD↓, 9,   SOD↑, 3,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TAC?, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↓, 2,   TrxR↑, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 6,   CDC25↓, 5,   compI↓, 2,   compIII↓, 2,   compV↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   Insulin↓, 1,   MFN2↓, 1,   mitResp↓, 3,   MKK7↓, 1,   mtDam↑, 13,   OCR↓, 4,   OXPHOS↓, 1,   OXPHOS↝, 1,   PDH↓, 1,   PDH↑, 1,   PDH↝, 1,   PINK1↑, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↑, 2,   ACC-α↓, 1,   ACC1↓, 1,   ACLY↓, 2,   p‑ACLY↓, 1,   adiP↑, 1,   ALAT↓, 2,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 15,   AMPK↝, 1,   p‑AMPK↑, 2,   ATP↓, 8,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   ECAR↓, 1,   FASN↓, 3,   GAPDH↓, 1,   glucose↝, 1,   GlucoseCon↓, 5,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 14,   GSK‐3β↓, 6,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 6,   HK1↓, 1,   HK2↓, 11,   HMG-CoA↓, 1,   lactateProd↓, 5,   LDHA↓, 4,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 2,   NADPH↓, 4,   NADPH↑, 1,   PCK1↓, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 2,   PFK↓, 1,   PFK1↓, 2,   PFK2↓, 1,   PIP3↑, 1,   PKM2↓, 5,   Pyruv↑, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   SIRT1↓, 7,   SIRT1↑, 3,   SIRT2↓, 1,   SREBP1/SREBF1↓, 3,   TCA↑, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 80,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 6,   Bak↑, 4,   BAX↓, 1,   BAX↑, 55,   Bax:Bcl2↑, 10,   Bcl-2↓, 63,   Bcl-2↑, 2,   Bcl-xL↓, 11,   Bcl-xL↑, 1,   BID↑, 2,   BIM↑, 8,   BNIP3↑, 2,   BOK↑, 1,   Casp↑, 12,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 1,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp2↑, 1,   Casp3↓, 2,   Casp3↑, 55,   cl‑Casp3↑, 16,   Casp6↑, 1,   Casp7↑, 7,   cl‑Casp7↑, 2,   Casp8↑, 11,   cl‑Casp8↑, 3,   Casp9↓, 1,   Casp9↑, 40,   p‑Casp9↑, 1,   cl‑Casp9↑, 5,   proCasp9↓, 1,   CellShr↑, 2,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 41,   mt-Cyt‑c↓, 1,   Diablo↑, 7,   DR5↑, 11,   FADD↑, 3,   Fas?, 1,   Fas↑, 13,   FasL↑, 1,   Ferroptosis↑, 3,   GSDMD↑, 1,   HEY1↓, 1,   IAP1↓, 3,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 7,   Mcl-1↓, 9,   MDM2↓, 6,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↑, 1,   NAIP↓, 1,   NOXA↑, 1,   oncosis↑, 1,   p38↓, 3,   p38↑, 4,   p‑p38↓, 4,   p‑p38↑, 2,   PUMA↓, 2,   PUMA↑, 2,   Pyro↑, 1,   survivin↓, 16,   survivin↝, 1,   TNFR 1↑, 2,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 4,   XIAP↓, 13,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 64,   Akt↑, 3,   p‑Akt↓, 23,   AKT1↓, 3,   Akt2↓, 1,   CIP2A↓, 1,   CK2↓, 5,   cMET↓, 2,   p‑cMET↓, 1,   cSrc↓, 1,   EGFR↓, 20,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 20,   ERK↑, 3,   p‑ERK↓, 9,   ERK5↑, 1,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 2,   IGFR↓, 1,   IKKα↓, 4,   p‑IκB↓, 2,   JAK↓, 2,   p‑JAK↓, 1,   JAK1↓, 2,   JAK2↓, 3,   p‑JAK2↓, 2,   JAK3↓, 1,   p‑JAK3↓, 1,   JNK↓, 1,   JNK↑, 4,   p‑JNK↓, 2,   p‑JNK↑, 1,   LIMK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 12,   MAPK↑, 5,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MARK4↓, 2,   MEK↓, 1,   MKK4↓, 1,   mTOR↓, 42,   mTOR↑, 1,   mTOR↝, 1,   p‑mTOR↓, 7,   mTORC2↓, 2,   p42↑, 1,   p70S6↓, 1,   PDGFRA↓, 2,   PI3K↓, 58,   PI3K↑, 1,   p‑PI3K↓, 5,   p‑PI3K↑, 1,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 16,   Raf↓, 1,   RAS↓, 4,   SHP1↑, 1,   Sp1/3/4↓, 5,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 1,   p‑STAT2↓, 1,   STAT3↓, 39,   p‑STAT3↓, 8,   p‑STAT3↑, 1,   STAT5↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 7,   p‑ATF4↝, 1,   cJun↓, 6,   cMyc↓, 26,   p‑cMyc↑, 1,   CREBBP↓, 1,   DNMT1↓, 3,   DNMT3A↓, 3,   DNMTs↓, 4,   EZH2↓, 7,   FOXM1↓, 4,   FOXO1↓, 3,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 2,   p‑FOXO3↓, 1,   FOXO4↓, 2,   FOXO4↑, 1,   H19↓, 1,   H3↓, 2,   p‑H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 1,   H3K27ac↓, 1,   H4↓, 1,   ac‑H4↓, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 12,   HDAC1↓, 4,   HDAC2↓, 4,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 1,   HES1↓, 1,   HOXB-AS1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-139-5p↑, 2,   miR-140↑, 1,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-19b↓, 2,   miR-200b↑, 1,   miR-200c↑, 2,   miR-203↑, 1,   miR-205↑, 1,   miR-21↓, 3,   miR-224↓, 1,   miR-29b↓, 1,   miR-301a-3p↓, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 2,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-448↑, 1,   miR-592↑, 1,   MTA2↓, 2,   Myc↓, 2,   NDRG1↑, 2,   OCT4↓, 12,   OCT4↑, 1,   other↓, 3,   other↑, 2,   other↝, 4,   other∅, 2,   PAX2↓, 1,   SOX2↓, 9,   SOX4↓, 2,   SOX4↑, 1,   TCF-4↓, 1,   tumCV↓, 16,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 9,   p‑CHOP/DDIT3↝, 1,   eIF2α↑, 2,   p‑eIF2α↑, 5,   p‑eIF2α↝, 1,   ER Stress↓, 1,   ER Stress↑, 14,   Erlin1↑, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP27↓, 5,   HSP70/HSPA5↓, 5,   HSP90↓, 3,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 5,   p‑PERK↝, 1,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 8,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 2,   LC3B↑, 1,   LC3B-II↑, 2,   LC3II↓, 1,   LC3II↑, 8,   LC3s↑, 1,   LysoPr↑, 1,   MitoP↑, 1,   p62↓, 8,   PARK2↑, 2,   TumAuto↓, 1,   TumAuto↑, 13,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 1,   BRCA1↓, 2,   DFF45↑, 2,   DNAdam↑, 20,   DNAdam⇅, 1,   mt-DNAdam↑, 1,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   hTERT/TERT↓, 9,   p16↑, 1,   P53?, 1,   P53↓, 1,   P53↑, 32,   p‑P53↑, 1,   ac‑P53↑, 1,   p53 Wildtype↑, 1,   PARP↓, 1,   PARP↑, 9,   cl‑PARP↑, 27,   PARP1↑, 2,   cl‑PARP1↑, 2,   PCNA↓, 18,   PCNA↑, 1,   POLD1↓, 1,   RAD51↓, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP2↓, 6,   TP53↑, 2,   XRCC1↓, 1,   γH2AX↑, 6,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 8,   CDK1/2/5/9↓, 1,   CDK2↓, 22,   CDK2↑, 2,   CDK4↓, 26,   CDK4↑, 1,   CDK6↓, 11,   CDK6↑, 1,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 2,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 13,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 41,   CycD3↓, 1,   cycE/CCNE↓, 8,   E2Fs↓, 1,   E2Fs↑, 1,   Ki-67↓, 17,   MAD↓, 1,   MKI67↑, 1,   P21↑, 26,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 13,   pRB↓, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   Securin↓, 1,   TAp63α↑, 1,   TumCCA↓, 4,   TumCCA↑, 79,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   ALDH1A1↓, 2,   AXIN1↓, 1,   AXIN1↑, 1,   Axin2↓, 1,   BMI1↓, 2,   BMPs↑, 1,   CD133↓, 4,   CD24↓, 2,   CD34↓, 1,   CDX2↓, 1,   cFos↓, 6,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 30,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 9,   GTPBP4↓, 1,   HH↓, 8,   IGF-1↓, 6,   IGFBP1↑, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Ki-67↓, 17,   Let-7↓, 1,   Let-7↑, 5,   LRP6↓, 1,   p‑LRP6↓, 1,   MSCmark↓, 1,   mTORC1↓, 2,   Nanog↓, 10,   Nanog↑, 1,   Nestin↓, 1,   NICD↓, 1,   NKD2↑, 1,   NOTCH↓, 8,   NOTCH⇅, 1,   NOTCH1↓, 13,   NOTCH1↑, 2,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH2↑, 1,   NOTCH3↓, 1,   p300↓, 1,   Piezo1↑, 1,   Pirin↓, 1,   PTCH1↓, 1,   SFRP5↑, 1,   Shh↓, 6,   Smo↓, 4,   p‑STAT1↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG↓, 45,   TumCG↑, 3,   TumCP?, 1,   TumCP↓, 70,   TumCP↑, 4,   tyrosinase↓, 1,   Wnt↓, 29,   Wnt/(β-catenin)↓, 4,   Wnt/(β-catenin)↑, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 2,   AEG1↑, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 4,   AP-1↝, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↑, 20,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↑, 2,   Cal9↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 5,   COL1A1↓, 1,   COL3A1↓, 1,   COL4↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 30,   E-cadherin↑, 211,   E-cadherin↝, 1,   EM↑, 1,   EMT↓, 148,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 2,   F-actin↑, 1,   FAK↓, 7,   FAK↑, 1,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 15,   Fibronectin↑, 1,   Galectin-9↓, 1,   GIT1↓, 1,   GLI2↓, 2,   ITGA5↑, 1,   ITGB1↓, 1,   ITGB1↑, 1,   ITGB4↓, 1,   LAMA5↑, 1,   LEF1↓, 1,   MALAT1↓, 3,   MET↓, 3,   MET↑, 2,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 3,   MMP1:TIMP1↑, 1,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 88,   MMP2↝, 1,   MMP3↓, 6,   MMP7↓, 10,   MMP9↓, 88,   MMP9↝, 1,   pro‑MMP9↓, 1,   MMPs↓, 17,   MTA1↓, 1,   MUC1↑, 1,   N-cadherin↓, 107,   N-cadherin↑, 3,   N-cadherin↝, 1,   p44↑, 1,   p‑pax↓, 1,   PDGF↓, 2,   PIR↓, 1,   Rac1↓, 1,   Rho↓, 4,   ROCK1↓, 3,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 31,   Smad1↓, 3,   SMAD2↓, 4,   p‑SMAD2↓, 7,   SMAD3↓, 5,   p‑SMAD3↓, 6,   Snail?, 1,   Snail↓, 74,   Snail↑, 4,   TET1↑, 3,   TGF-β↓, 14,   TGF-β↑, 2,   TGF-β1↓, 2,   TIMP1↓, 2,   TIMP1↑, 5,   TIMP2↓, 3,   TIMP2↑, 5,   TIMP3↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI?, 2,   TumCI↓, 83,   TumCI↑, 1,   TumCMig?, 1,   TumCMig↓, 90,   TumCMig↑, 1,   TumMeta↓, 53,   TumMeta↑, 2,   Twist↓, 34,   Twist↑, 2,   Tyro3↓, 1,   uPA↓, 15,   uPAR↓, 2,   Vim?, 1,   Vim↓, 128,   Vim↑, 6,   vinculin↓, 1,   Zeb1↓, 31,   Zeb1↑, 2,   ZEB2↓, 3,   ZEB2↑, 2,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 55,   β-catenin/ZEB1↑, 1,   p‑β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 34,   angioG↑, 3,   CD31/PECAM-1↓, 3,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 29,   Hif1a↑, 1,   Hif1a↝, 1,   NO↓, 3,   NO↑, 1,   NO↝, 1,   TXA2↓, 1,   VCAM-1↓, 2,   VEGF↓, 59,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 10,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,   CLDN1↓, 4,   CLDN2↓, 1,   CLDN2↑, 1,   CLDN7↑, 1,   GLUT1↓, 2,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↑, 1,   MMP↓, 42,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 1,   OCLN↑, 1,   TRPV1↑, 1,   ZO-1↑, 10,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↓, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 10,   CD44↑, 1,   CD59↑, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 37,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 2,   CXCL12↓, 1,   CXCR4↓, 9,   DR4↑, 2,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   FoxP3+↓, 1,   HMGB1↓, 3,   ICAM-1↓, 4,   IFN-γ↓, 3,   IFN-γ↑, 2,   Igs↑, 1,   IL1↓, 2,   IL10↓, 3,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 9,   IL2↓, 2,   IL2↑, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 21,   IL6↑, 1,   IL8↓, 11,   IL8↑, 1,   Imm↑, 4,   Imm↝, 1,   Inflam↓, 8,   IRAK1↓, 2,   pol-M1↑, 1,   MCP1/CCL2↓, 2,   MIP-1β↑, 1,   Neut↑, 1,   NF-kB↓, 65,   NF-kB↑, 2,   p‑NF-kB↑, 2,   NK cell↑, 4,   NLRP3↓, 3,   p50↓, 2,   p65↓, 4,   p65↑, 1,   p‑p65↓, 3,   PD-1↓, 4,   PD-L1↓, 6,   PD-L1↑, 1,   PD-L2↓, 1,   PGE2↓, 13,   PSA↓, 6,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 3,   TCF↑, 1,   Th1 response↑, 3,   Th17↑, 1,   TILs↑, 1,   TIM-3↓, 1,   TLR4↓, 2,   TNF-α↓, 12,   TNF-α↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↓, 1,   AR↓, 7,   AR↑, 1,   ER(estro)↓, 1,   FGF21↓, 1,   PPARα↓, 1,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 2,   RANKL↓, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 13,   BioAv↝, 5,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 59,   ChemoSen⇅, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP3A4↓, 1,   Dose↑, 3,   Dose↝, 21,   Dose∅, 5,   eff↓, 9,   eff↑, 21,   eff↝, 7,   eff∅, 1,   Half-Life↓, 6,   Half-Life↑, 1,   Half-Life↝, 3,   MDR1↓, 5,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 4,   P450↓, 3,   RadioS↑, 23,   selectivity↑, 27,   selectivity↝, 1,   Synergy?, 1,   Synergy↑, 56,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 7,   AR↑, 1,   AST↓, 1,   BRCA1↓, 2,   CEA↓, 1,   CRP↓, 1,   EGFR↓, 20,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 7,   Ferritin↓, 1,   FOXM1↓, 4,   HER2/EBBR2↓, 6,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 9,   IL6↓, 21,   IL6↑, 1,   LDH↓, 6,   LDH↑, 1,   Myc↓, 2,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 6,   RAGE↓, 1,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 21,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↓, 1,   AntiTum↑, 12,   cachexia↓, 3,   cardioP↑, 6,   chemoP↑, 12,   chemoPv↑, 6,   ChemoSideEff↓, 5,   fatigue↓, 1,   hepatoP↑, 5,   neuroP↑, 4,   NKG2D↑, 1,   OS↑, 11,   Pain↓, 1,   Pin1↓, 1,   QoL↑, 1,   radioP↑, 4,   RenoP↑, 3,   Risk↓, 5,   toxicity?, 1,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 2,   TumVol↓, 10,   TumW↓, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 6,  
Total Targets: 891

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 31,   Catalase↑, 18,   GPx↓, 1,   GPx↑, 12,   GSH↑, 12,   GSR↑, 2,   GSTs↑, 6,   HDL↑, 1,   HO-1↑, 8,   Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 14,   MDA↓, 8,   MPO↓, 1,   NQO1↑, 3,   NRF2↑, 18,   RNS↓, 1,   ROS↓, 39,   SOD↓, 1,   SOD↑, 19,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,   ALAT↓, 5,   AMPK↑, 2,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   GSK‐3β↓, 1,   LDHA↑, 1,   lipidLev↓, 1,   NAD↑, 1,   NH3↓, 1,   PLA2↓, 1,   SIRT1↑, 5,  

Cell Death(tgid=5) ⓘ

BAX↓, 3,   Bcl-2↑, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 6,   Casp9↓, 3,   Cyt‑c↓, 3,   Ferroptosis↓, 1,   iNOS↓, 3,   MLKL↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 4,   p‑Akt↓, 1,   p‑Akt↑, 1,   CaMKII ↓, 1,   CREB↑, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   IκB?, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 5,   mTOR↑, 3,   p‑mTOR↓, 1,   PI3K↓, 3,   PI3K↑, 4,   PKCδ↓, 1,   PTEN↑, 1,   RAS↓, 1,   RIP1↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4,   p‑cMyc↑, 1,   HDAC↓, 1,   HOTAIR↑, 1,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   IRE1↓, 1,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 3,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↝, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 1,   Ca+2↝, 1,   cal2↓, 1,   COL1↓, 3,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 7,   EMT↓, 4,   EMT↑, 1,   F-actin↓, 1,   Fibronectin↓, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Smad7↑, 2,   Snail↓, 1,   TGF-β↓, 2,   TGF-β1↓, 1,   TIMP1↓, 1,   TregCell↑, 1,   TumCMig↓, 1,   TumMeta↓, 1,   Vim↓, 6,   Zeb1↓, 1,   α-SMA↓, 6,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   Hif1a↓, 1,   NO↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   IBI↑, 2,   MMP↑, 3,   TRPC1↓, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 8,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 2,   IL12↓, 1,   IL1RL1/ST2↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL33↓, 1,   IL4↓, 1,   IL5↓, 2,   IL6↓, 11,   IL8↓, 2,   ILC2↓, 1,   Imm↑, 2,   Inflam↓, 31,   Inflam↑, 1,   LPS↓, 1,   NeuroI↓, 1,   NF-kB↓, 10,   NK cell↑, 1,   PGE2↓, 7,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 4,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 5,   BDNF↑, 1,   MAOA↓, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   BACE/β-secretase↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,   CYP19↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 18,   BioAv↑, 5,   BioAv↝, 5,   BioEnh↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose↝, 1,   eff↑, 2,   GSTA1↑, 1,   Half-Life↝, 3,   P450↓, 2,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 3,   AST↓, 7,   BP↓, 1,   BUN↓, 1,   creat↓, 2,   CRP↓, 1,   IL6↓, 11,   LDH↓, 2,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 7,   AntiArt↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 6,   AntiTum↑, 4,   cardioP↑, 13,   CardioT↓, 1,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 4,   hepatoP↑, 13,   Learn↑, 1,   memory↑, 7,   motorD↑, 1,   Mucositis↓, 2,   neuroP↑, 19,   Obesity↓, 2,   radioP↑, 1,   RenoP↑, 3,   Stroke↓, 3,   toxicity↓, 10,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   GutMicro↑, 3,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 228

Scientific Paper Hit Count for: E-cadherin, E-cadherin
16 Curcumin
11 Resveratrol
11 Luteolin
8 Sulforaphane (mainly Broccoli)
7 Fisetin
7 Quercetin
6 Pterostilbene
6 Thymoquinone
5 Honokiol
5 Matrine
4 Astragalus
4 Cisplatin
4 Apigenin (mainly Parsley)
4 Artemisinin
4 Berberine
4 Benzyl isothiocyanate
4 Chrysin
4 Inositol
4 Piperine
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
3 Baicalein
3 Propolis -bee glue
3 Cinnamon
3 5-fluorouracil
3 Cyclopamine
3 Eugenol
3 phytic acid, Inositol hexakisphosphate
3 Isorhamnetin
3 Magnolol
3 Urolithin
2 Allicin (mainly Garlic)
2 Baicalin
2 Biochanin A
2 Betulinic acid
2 Boron
2 Capsaicin
2 Carvacrol
2 Chlorogenic acid
2 Hydroxycinnamic-acid
2 Citric Acid
2 Diindolylmethane
2 Ellagic acid
2 Emodin
2 Fucoidan
2 Garcinol
2 Grapeseed extract
2 Hydrogen Gas
2 Isoliquiritigenin
2 Isothiocyanates
2 Phenethyl isothiocyanate
2 Juglone
2 Kaempferol
2 Laetrile B17 Amygdalin
2 Lycopene
2 Marjoram (Origanum majorana)
2 Phycocyanin
2 Piperlongumine
2 Shikonin
2 Selenite (Sodium)
2 Ursolic acid
2 Vitamin D3
2 VitK3,menadione
1 1,8-Cineole
1 3-bromopyruvate
1 Alpha-Lipoic-Acid
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Aspirin
1 Astaxanthin
1 Beta-Caryophyllene
1 Boswellia (frankincense)
1 brusatol
1 Butyrate
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cannabidiol
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Crocetin
1 Oxaliplatin
1 diet FMD Fasting Mimicking Diet
1 Indole-3-carbinol
1 Ginkgo biloba-EGb 761
1 EGCG (Epigallocatechin Gallate)
1 Eurycomanone
1 Evodiamine
1 Ferulic acid
1 Sorafenib (brand name Nexavar)
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Paclitaxel/Taxol
1 Ginkgo biloba
1 Ginkgolide B
1 Proanthocyanidins
1 Chemotherapy
1 HydroxyTyrosol
1 capecitabine
1 Allyl isothiocyanate
1 L-Theanine
1 Licorice
1 Metformin
1 Mangiferin
1 Melatonin
1 Morin
1 Naringin
1 Oroxylin-A
1 Oleuropein
1 Phenylbutyrate
1 Docetaxel
1 Rutin
1 salinomycin
1 Selenate
1 Sesamin
1 Spirulina(Arthrospira/Limnospira)
1 statins
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:89  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page