tumCV Cancer Research Results

tumCV, Cell Viability: Click to Expand ⟱
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Cell Viability
Scientific Papers found: Click to Expand⟱
6319- DRE,    Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells
- in-vitro, AML, MV411 - in-vitro, AML, HL-60
Apoptosis↑, TumAuto↑, *toxicity↓, selectivity↑, Casp8↑, MMP↓, *Inflam↓, *antiOx↑, *AntiCan↑, DNAdam↑, cl‑Casp3↑, tumCV↓, ROS↑,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
6352- DRE,    Investigation of the Anti-Lung Cancer Mechanisms of Taraxacum officinale Based on Network Pharmacology and Multidimensional Experimental Validation
- in-vitro, Lung, A549 - in-vitro, Nor, L929
other↝, other↝, tumCV↑, selectivity?, EGFR↓, AKT1↓, NQO1↓,
6358- DRE,    Dandelion root extracts and taraxasterol inhibit LPS‑induced colorectal cancer cell viability by blocking TLR4‑NFκB‑driven ACE2 and TMPRSS2 pathways
- in-vitro, CRC, NA
TLR4↓, NF-kB↓, TNF-α↓, IL4↓, IL6↓, tumCV↓,
6367- DRE,    Antioxidant and antimicrobial activities of Dandelion root extract (Taraxacum officinale) and its cytotoxic effect on MDA-MB-231 breast cancer cells
- in-vitro, BC, MDA-MB-231
TumCD↑, *antiOx↑, *ROS↓, tumCV↓, Apoptosis↑, ROS↑, TumCCA↑, MOMP↑, ROS↑,
6361- DRE,    Taraxacum officinale Seed Extract Inhibits HeLa Cell Migration at Sub-cytotoxic Concentrations
- in-vitro, Cerv, HeLa
tumCV↓, TumCMig↓,
6362- DRE,    Taraxacum spp. in vitro and in vivo anticancer activity – A review
- Review, Var, NA
tumCV↓, *AntiDiabetic↑, *Imm↑,
4913- DSF,    Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
- Review, Var, NA
Apoptosis↑, tumCV↑, eff↑, toxicity↓, antiNeop↑, ChemoSen↑, RadioS↑, OS↑, ROS↑, SOD↓, MMP1↓, Synergy↑, Half-Life↓,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
6607- Ech,    Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines
- in-vitro, PC, MIA PaCa-2 - in-vitro, CRC, Colo320
tumCV↓, eff↑, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, Imm↑, NK cell↑, PGE2↓, COX1↓, COX2/PTGS2↓, 5LO↓,
6608- Ech,  CBC,    The pro-apoptosis effects of Echinacea purpurea and Cannabis sativa extracts in human lung cancer cells through caspase-dependent pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, ROS↑, Casp3↑, TumCD↑,
6620- Ech,    Echinacea purpurea diminishes neovascular reaction induced in mice skin by human cancer cells and stimulates non-specific cellular immunity in humans
- in-vivo, Var, NA
angioG↓, *NK cell↑, Imm↑, Inflam↓, tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, MMPs↓, other↑,
7237- EGb 761,    Ginkgo biloba Extract Mechanism Inhibits Hepatocellular Carcinoma through the Nuclear Factor-κB/p53 Signaling Pathway
- in-vitro, HCC, HepG2
TumCG↓, tumCV↓, Apoptosis↑, P53↑, NF-kB↓,
3241- EGCG,    Epigallocatechin gallate triggers apoptosis by suppressing de novo lipogenesis in colorectal carcinoma cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↓, mtDam↑, Apoptosis↑, ATP↓, lipoGen↓, ChemoSen↑,
5223- EMD,    Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
- in-vitro, CRC, DLD1 - in-vitro, Nor, CCD841
tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6815- EMD,    NMR-based Metabolomic Techniques Identify the Toxicity of Emodin in HepG2 Cells
- in-vitro, Liver, HepG2
AntiCan↑, *hepatoP↑, *Inflam↓, *antiOx↑, *AntiBio↑, *toxicity↝, tumCV↓, TumCP↓, Apoptosis↑, ALAT↓, glucose↓, GSH↓, ATP↓,
1332- EMD,    Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway
- in-vivo, Nor, HepaRG
*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,
1321- EMD,    Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model
- in-vitro, CRC, LS1034 - in-vivo, NA, NA
tumCV↓, TumCCA↑, ROS↑, Ca+2↑, MMP↓, Apoptosis↑, Cyt‑c↑, Casp9↑, Bax:Bcl2↑,
1330- EMD,    Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway
- in-vitro, Var, NA
tumCV↓, Casp3↑, Casp9↑, MMP↓, Cyt‑c↑, BAX↑, Bax:Bcl2↑,
3460- EP,    Picosecond pulsed electric fields induce apoptosis in HeLa cells via the endoplasmic reticulum stress and caspase-dependent signaling pathways
- in-vitro, Cerv, HeLa
tumCV↓, Apoptosis↑, TumCCA↑, GRP78/BiP↑, GRP94↑, CEBPA↑, CHOP/DDIT3↑, Ca+2↑, Casp12↑, Casp9↑, Casp3↑, Cyt‑c↑, BAX↑, Bcl-2↓, ER Stress↑, MMP↓,
6793- EPA,    Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells
- in-vitro, Pca, PC3
tumCV↓, ERK↓, PTK2B / PYK2↓, TumCG↓, ROS↑, TumCMig↓, TumCI↓,
6796- EPA,    Effect of eicosapentaenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines
- in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, PANC1
TumCG↓, eff↓, lipid-P↑, tumCV↓, ROS↑,
6797- EPA,    Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocarcinoma cells and rat colon in vivo
- in-vivo, Colon, HT29
tumCV↓, Casp3↑, eff↓, eff↑, Apoptosis↑, ROS↑,
975- Est,    Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism
- vitro+vivo, UEC, NA
GLS↑, cMyc↑, GlutMet↑, tumCV↑, TumAuto↓,
6578- EU,    Eurycomanol and eurycomanone as potent inducers for cell-cycle arrest and apoptosis in small and large human lung cancer cell lines
- in-vitro, Lung, H460 - in-vitro, Lung, A549
Dose↝, selectivity↑, tumCV↓, TumCCA↓, Apoptosis↑,
6579- EU,    Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation
- in-vitro, AML, K562
tumCV↓, TumCP↓, selectivity↑, NF-kB↓, IKKα↓, MAPK↓,
6583- EU,    Inactivation of AKT/NF-κB signaling by eurycomalactone decreases human NSCLC cell viability and improves the chemosensitivity to cisplatin
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, Calu-1
tumCV↓, TumCCA↑, Casp3↑, PARP↑, Bcl-xL↓, survivin↓, Akt↓, NF-kB↓, ChemoSen↑,
6584- EU,    Eurycoma longifolia: an overview on the pharmacological properties for the treatment of common cancer
- Review, Var, NA
*AntiAge↑, *Inflam↓, *antiOx↑, TumCD↑, Bcl-2↓, cl‑Casp7↑, cl‑PARP↑, BAX↑, P53↑, tumCV↓, selectivity↑, *testos↑, *PSA∅,
6390- Eug,    Molecular mechanisms of eugenol as an antitumour bioactive compound: A comprehensive review
- Review, Var, NA
TumCCA↑, angioG↓, TumMeta↓, tumCV↓, Casp3↑, Casp6↑, DFF45↑, PARP↑, ROS↑, Cyt‑c↑, MPT↑, *ROS↓, NF-kB↓, COX2/PTGS2↓, 5LO↓, EMT↓, Snail↓, E-cadherin↑, Vim↓, PI3K↓, Akt↓, mTORC2↓, TumAuto↑, FOXO3↓, Apoptosis↑, ChemoSen↑, RadioS↑, DNMT1↓, DNMT3A↓,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *CompStab↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *Synergy↑, NF-kB↓, PGE2↓, COX2/PTGS2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑, *antiAll↑,
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,
6338- Eug,    Tumor suppressive roles of eugenol in human lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCMig↓, TumCI↓, Akt↓, MMP2↓, *lipid-P↓, *COX2/PTGS2↓, *ROS↓, PI3K↓,
6340- Eug,    Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
tumCV↓, E2Fs↓, survivin↓, NF-kB↓, cycD1/CCND1↓, P21↑, TumCP↓, Apoptosis↑, TumCI↓, angioG↓,
6341- Eug,    A Metabolomic Investigation of Eugenol on Colorectal Cancer Cell Line HT-29 by Modifying the Expression of APC, p53, and KRAS Genes
- in-vitro, Colon, HT29
*antiOx↑, ROS↑, tumCV↓, P53↑, APC↑, KRAS↓, FAO↓, Glycolysis↓,
6845- EVO,    Evodiamine, a Novel NOTCH3 Methylation Stimulator, Significantly Suppresses Lung Carcinogenesis in Vitro and in Vivo
- vitro+vivo, NSCLC, A549 - in-vitro, Lung, H1299
AntiCan↑, TumVol↓, NOTCH3↓, tumCV↓, TumCCA↑, TumCMig↓, CSCs↓, TumCP↓, Apoptosis↑, TumCI↓, ROS↑, TumCG↓, selectivity↑, DNMT1↓,
6839- EVO,    Activation of JNK Contributes to Evodiamine-Induced Apoptosis and G2/M Arrest in Human Colorectal Carcinoma Cells: A Structure-Activity Study of Evodiamine
- in-vitro, CRC, COLO205 - in-vitro, Colon, HT29
tumCV↓, cl‑Casp3↑, PARP↑, MMP↓, BAX↑, Casp9↑, Cyt‑c↑, TumCCA↑, JNK↑,
6840- EVO,    Evodiamine Induces G2/M Arrest and Apoptosis via Mitochondrial and Endoplasmic Reticulum Pathways in H446 and H1688 Human Small-Cell Lung Cancer Cells
- in-vitro, Lung, H446 - in-vitro, Lung, H1688
tumCV↓, TumCCA↑, Apoptosis↑, Casp12↑, Cyt‑c↑, BAX↑, Bcl-2↓, selectivity↑, ROS↑, Ca+2↑, MMP↓,
1112- FA,    Ferulic acid exerts antitumor activity and inhibits metastasis in breast cancer cells by regulating epithelial to mesenchymal transition
- in-vitro, BC, MDA-MB-231 - in-vivo, BC, NA
tumCV↓, Apoptosis↑, AntiTum↑, TumMeta↓, EMT↓, TumVol↓, TumW↓,
6857- FBZ,    Fenbendazole induces pyroptosis in breast cancer cells through HK2/caspase-3/GSDME signaling pathway
- vitro+vivo, BC, NA
tumCV↓, Pyro↑, cl‑Casp3↑, GSDME↑, IL1β↑, Glycolysis↓, HK2↓, TumVol↓, TumW↓, toxicity↓,
6427- FEO,    Foeniculum vulgare seed extract exerts anti-cancer effects on hepatocellular carcinoma
- vitro+vivo, HCC, NA
tumCV↓, Apoptosis↑, TumCMig↓, TumCG↓, survivin↓, mtDam↑, Casp3↑,
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
6909- FIS,    Modulation of PI3K/ AKT/ mTOR and apoptosis pathway in colon cancer cells by the plant flavonoid fisetin
- in-vitro, Colon, Caco-2
AntiCan↑, tumCV↓, Bcl-2↓, PI3K↓, mTOR↓, NF-kB↓, BAX↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *antiOx↑, *neuroP↑,
6899- FIS,    Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1
Dose↝, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↑, CDK4↑, CDK6↑, P21↑, p27/CDKN1B↑, Apoptosis↑, cl‑PARP↑, Cyt‑c↑, XIAP↓, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, PI3K↓, Akt↓,
2847- FIS,    Fisetin-induced cell death, apoptosis, and antimigratory effects in cholangiocarcinoma cells
- in-vitro, CCA, NA
tumCV↓, ChemoSen↑, TumCMig↓, ROS↑, TumCI↓, angioG↓, CDK2↓, PI3K↓, Akt↓, mTOR↓, EGFR↓, Casp↑, mTORC1↓, mTORC2↑, cycD1/CCND1↓, cycE/CCNE↓, MMP2↓, MMP9↓, ER Stress↑, Ca+2↑, eff↓,
2851- FIS,    Apoptosis induction in breast cancer cell lines by the dietary flavonoid fisetin
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, SkBr3 - in-vitro, Nor, NA
tumCV↓, selectivity↑, TumCCA↑, Apoptosis↑, ROS∅,
2856- FIS,    N -acetyl- L -cysteine enhances fisetin-induced cytotoxicity via induction of ROS-independent apoptosis in human colonic cancer cells
- in-vitro, Colon, COLO205
Synergy↑, ROS↑, tumCV↓, Casp3↑, Bcl-2↓, MMP↓, eff↑,
2844- FIS,    Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells
- in-vitro, OS, U2OS
tumCV↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, BAD↑, Bcl-2↓, Bcl-xL↓, PI3K↓, Akt↓, ERK↓, p‑JNK↑, p‑cJun↑, p‑p38↑, ROS↑, MMP↓, mTORC1↓, PTEN↑, p‑GSK‐3β↓, GSK‐3β↑, NF-kB↓, IKKα↑, Cyt‑c↑,
2841- FIS,    Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer
- in-vitro, Nor, RAW264.7 - in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B - in-vitro, Liver, HUH7
*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP/DDIT3↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,

Showing Research Papers: 201 to 250 of 622
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 622

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 2,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 2,   antiOx↑, 10,   ARE/EpRE↑, 1,   Catalase↓, 7,   Catalase↑, 5,   Fenton↑, 2,   GPx↓, 2,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 9,   GPx4↑, 1,   GPx4∅, 1,   GSH↓, 22,   GSH↑, 4,   GSH⇅, 1,   GSH∅, 1,   GSH/GSSG↓, 2,   GSR↓, 2,   GSS↑, 1,   GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 2,   e-H2O2↓, 1,   i-H2O2∅, 1,   HO-1↓, 6,   HO-1↑, 7,   HO-2↓, 1,   HO-2↑, 1,   Iron↑, 5,   Iron↝, 1,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 7,   lipid-P↑, 10,   MDA?, 1,   MDA↑, 8,   NOX↓, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 12,   NRF2↑, 9,   p‑NRF2↑, 2,   p66Shc↓, 1,   p66Shc↑, 1,   Prx↓, 1,   ROS?, 3,   ROS↓, 31,   ROS↑, 232,   ROS⇅, 1,   ROS↝, 1,   ROS∅, 3,   i-ROS↑, 1,   mt-ROS↑, 13,   SOD↓, 8,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 4,   TAC↓, 1,   TAC↑, 2,   TBARS↑, 2,   Thiols↓, 2,   Thiols↝, 1,   TKT↓, 1,   Trx↓, 2,   Trx1↑, 1,   TrxR↓, 2,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   STEAP3↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 7,   compI↓, 3,   compII↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 2,   ETC↓, 2,   KIF2C↓, 1,   MFN2↓, 1,   mitResp↓, 3,   mitResp↑, 1,   mtDam↑, 28,   OCR↓, 4,   OXPHOS↓, 3,   OXPHOS↑, 3,   PDH↓, 1,   PDH↑, 1,   PINK1↑, 3,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACC↓, 2,   p‑ACC↑, 1,   ACLY↓, 1,   ALAT↓, 3,   AMP↑, 1,   AMPK↑, 18,   p‑AMPK↑, 4,   ATP↓, 17,   citrate↓, 1,   ECAR↓, 2,   ECAR↝, 1,   FAO↓, 1,   FASN↓, 3,   FASN↑, 1,   i-FASN↓, 1,   FBPase↑, 1,   G6PD↓, 1,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↑, 1,   glucoNG↑, 1,   glucose↓, 2,   GlucoseCon↓, 9,   GlucoseCon∅, 1,   GlutMet↓, 1,   GlutMet↑, 1,   Glycolysis↓, 25,   GSK‐3β↓, 2,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 4,   Histones↑, 1,   HK2↓, 7,   HMG-CoA↓, 1,   IDH1↑, 1,   lactateProd↓, 12,   lactateProd∅, 1,   LDHA↓, 4,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 2,   NADPH↓, 1,   O-Glc↓, 1,   PDHB↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 4,   PDKs↓, 1,   PFK↓, 2,   PGK1↓, 1,   PKM2↓, 11,   p‑S6↓, 1,   SIRT1↓, 1,   SIRT1↑, 3,   SIRT2↓, 1,   TCA↓, 1,   TS↓, 1,   Warburg↓, 1,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 13,   AIF↝, 1,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 8,   Apoptosis↑, 288,   Apoptosis∅, 1,   mt-Apoptosis↑, 2,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 7,   Bak↑, 3,   BAX↓, 2,   BAX↑, 107,   Bax:Bcl2↑, 26,   Bcl-2↓, 112,   Bcl-2↑, 2,   Bcl-xL↓, 20,   Bcl-xL↑, 2,   BID↑, 3,   BIM↑, 2,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 27,   cl‑Casp↑, 2,   proCasp↑, 1,   cl‑Casp1↑, 1,   Casp12↑, 6,   Casp3↓, 1,   Casp3↑, 155,   cl‑Casp3↓, 1,   cl‑Casp3↑, 40,   proCasp3↓, 1,   proCasp3↑, 1,   pro‑Casp3↓, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 2,   Casp7↑, 22,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 30,   Casp8∅, 1,   cl‑Casp8↑, 4,   Casp9↓, 2,   Casp9↑, 82,   cl‑Casp9↑, 17,   cFLIP↓, 3,   Cyt‑c↓, 1,   Cyt‑c↑, 70,   Diablo↑, 1,   DR5↑, 3,   Endon↑, 2,   FADD↑, 2,   Fas↑, 7,   FasL↑, 9,   Ferroptosis↓, 1,   Ferroptosis↑, 16,   cl‑GSDMD↑, 1,   GSDME↑, 1,   GSDME-N↑, 1,   IAP1↓, 1,   iNOS↓, 4,   Mcl-1↓, 14,   MDM2↓, 8,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 2,   NAIP↓, 1,   Necroptosis↑, 3,   necrosis↑, 4,   NOXA↑, 2,   p38↓, 4,   p38↑, 6,   p‑p38↓, 3,   p‑p38↑, 6,   PDCD4↑, 1,   proApCas↑, 1,   PUMA↑, 4,   Pyro↑, 4,   RIP3↑, 1,   p‑RIP3↑, 2,   survivin↓, 40,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 19,   TumCD∅, 1,   TUNEL↑, 1,   XIAP↓, 12,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 82,   Akt↑, 4,   p‑Akt↓, 37,   AKT1↓, 2,   Brk/PTK6↓, 1,   CaMKII ↓, 1,   CaMKII ↑, 1,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 1,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 19,   p‑EGFR↓, 2,   ERK↓, 23,   ERK↑, 6,   ERK↝, 1,   p‑ERK↓, 12,   p‑ERK↑, 3,   GRB2↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   HRAS↓, 1,   IGF-1R↓, 5,   IKKα↓, 3,   IKKα↑, 1,   p‑IκB↓, 1,   JAK↓, 1,   JAK1↓, 4,   JAK2↓, 9,   p‑JAK2↓, 1,   JNK↓, 4,   JNK↑, 12,   p‑JNK↓, 1,   p‑JNK↑, 6,   LIFR/CD118↓, 1,   MAPK↓, 10,   MAPK↑, 10,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 2,   MEK↓, 5,   p‑MEK↑, 1,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 47,   mTOR↑, 2,   p‑mTOR↓, 12,   mTORC2↓, 1,   mTORC2↑, 1,   p‑p70S6↓, 1,   P70S6K↓, 1,   p‑P70S6K↓, 2,   PI3K?, 1,   PI3K↓, 54,   PI3K↑, 1,   p‑PI3K↓, 13,   PI3k/Akt/mTOR↓, 2,   PKA↓, 2,   PKCδ↓, 3,   PKCδ↑, 1,   PRKCQ/PKCθ↓, 1,   PTEN↑, 8,   PTK2B / PYK2↓, 1,   e-Raf↓, 1,   RAS↓, 4,   RAS↑, 1,   RCC1↓, 1,   RIP1↓, 1,   Sp1/3/4↓, 6,   Src↓, 1,   STAT↓, 3,   STAT3↓, 40,   STAT3↑, 1,   p‑STAT3↓, 15,   STAT4↓, 1,   STAT4↑, 1,   STAT5↓, 4,   p‑STK11/LKB1↑, 2,   TK1↓, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 4,   ChrMod↝, 1,   cJun↓, 1,   p‑cJun↑, 1,   cMyc↓, 16,   cMyc↑, 2,   DNMT1↓, 6,   DNMT3A↓, 4,   DNMT3B↓, 2,   DNMTs↓, 2,   FOXM1↓, 1,   FOXO1↓, 1,   FOXO3↓, 2,   p‑FOXO3↓, 1,   FOXO4↓, 1,   GATA3↑, 1,   ac‑H3↑, 3,   ac‑H3↝, 1,   ac‑H4↑, 3,   HATs↓, 1,   HDAC↓, 8,   HDAC1↓, 4,   HDAC2↓, 4,   HDAC3↓, 2,   HDAC6↓, 1,   HMTs↓, 2,   JHDM1D-AS1↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-148a↑, 1,   miR-149↑, 1,   miR-155↓, 2,   miR-21↓, 2,   miR-22↑, 1,   miR-224↓, 1,   miR-27a-3p↓, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-422a↑, 1,   miR-542↓, 1,   Myc↓, 2,   OCT4↓, 6,   other↓, 1,   other↑, 3,   other↝, 9,   SALL4↓, 1,   SBF2-AS1↓, 1,   sonoS↑, 1,   SOX2↓, 6,   SOX4↓, 1,   SUV39H↓, 2,   TBX15↑, 1,   TET3↑, 1,   TLE1↓, 1,   tumCV?, 6,   tumCV↓, 593,   tumCV↑, 11,   tumCV∅, 7,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 4,   c-ATF6↑, 1,   CHOP/DDIT3↑, 20,   eIF2α↑, 3,   p‑eIF2α↑, 5,   ER Stress↓, 1,   ER Stress↑, 32,   ERStress↑, 1,   GRP78/BiP↑, 16,   GRP94↑, 4,   HSF1↓, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP70/HSPA5⇅, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 4,   IRE1↑, 2,   PERK↑, 3,   p‑PERK↑, 4,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 4,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 11,   CTSB↓, 2,   CTSD↓, 2,   LC3A↑, 1,   LC3B↑, 5,   LC3B-II↑, 2,   LC3I↑, 2,   LC3II↑, 11,   LC3s↑, 1,   MitoP↑, 3,   p62↓, 6,   p62↑, 4,   PARK2↑, 3,   SESN2↑, 1,   TumAuto↓, 4,   TumAuto↑, 41,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 1,   ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 1,   DNAdam↑, 65,   DNArepair↓, 1,   hTERT/TERT↓, 3,   Ku70/XRCC6↓, 1,   NHEJ↓, 1,   P53?, 1,   P53↓, 2,   P53↑, 57,   P53⇅, 1,   P53↝, 1,   p‑P53↑, 3,   p53 Wildtype↓, 1,   PARP↓, 5,   PARP↑, 15,   p‑PARP↑, 1,   cl‑PARP↓, 3,   cl‑PARP↑, 54,   PARP1↑, 2,   cl‑PARP1↑, 3,   PCNA↓, 14,   POLD1↓, 1,   SIRT6↑, 1,   Telomerase↓, 5,   TOP1↓, 1,   TOP2↓, 3,   TP53↑, 1,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↑, 7,   p‑γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 10,   CDK1↑, 1,   p‑CDK1↑, 1,   CDK2↓, 11,   CDK2↑, 1,   CDK4↓, 16,   CDK4↑, 1,   CDK6↓, 9,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   ChrCon↑, 2,   cycA1/CCNA1↓, 6,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 11,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 48,   CycD3↓, 3,   CycD3↑, 1,   cycE/CCNE↓, 14,   cycE1↓, 2,   E2Fs↓, 2,   Ki-67↓, 19,   mitA↑, 2,   MKI67↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 35,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 13,   PLK1↓, 1,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 2,   RB1↑, 1,   p‑RB1↓, 2,   Securin↓, 1,   TumCCA?, 3,   TumCCA↓, 2,   TumCCA↑, 157,   TumCCA⇅, 1,   TumCCA∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 2,   ALDH↓, 3,   ALDH1A1↓, 1,   Axin2↓, 1,   BMI1↓, 1,   BMPs↑, 1,   CD133↓, 5,   CD24↓, 2,   CEBPA↑, 1,   cFos↓, 2,   CSCs↓, 17,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 1,   HH↓, 3,   HMGCR↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   Ki-67↓, 19,   LRP6↓, 1,   mTORC1↓, 4,   Nanog↓, 4,   Nestin↓, 2,   NOTCH↓, 3,   NOTCH1↓, 3,   NOTCH3↓, 1,   Piezo1↑, 1,   Shh↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG?, 2,   TumCG↓, 81,   TumCG↑, 2,   TumCG∅, 1,   TumCP↓, 116,   TumCP↑, 2,   Wnt↓, 14,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AKR1C2↓, 1,   Alix/AIP‑1↓, 1,   annexin II↓, 1,   AntiAg↑, 1,   AP-1↓, 1,   APC↑, 1,   Ca+2↓, 2,   Ca+2↑, 20,   Ca+2↝, 5,   i-Ca+2↓, 1,   i-Ca+2↑, 4,   Cal1↑, 2,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 2,   COL1↓, 1,   COL4↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 14,   EMT?, 1,   EMT↓, 31,   F-actin↓, 1,   F-actin↑, 1,   FAK↓, 3,   p‑FAK↓, 1,   Fibronectin↓, 2,   IQGAP3↓, 1,   KRAS↓, 4,   LEF1↓, 1,   MET↑, 1,   MMP1↓, 4,   MMP16↓, 1,   MMP2↓, 37,   MMP3↓, 3,   MMP7↓, 4,   MMP7∅, 1,   MMP9↓, 32,   MMP9:TIMP1↓, 1,   MMPs↓, 12,   N-cadherin↓, 8,   N-cadherin↑, 2,   PAK1↓, 2,   proline↓, 1,   Rac1↓, 2,   Rho↓, 1,   Rho↑, 1,   Slug?, 1,   Slug↓, 7,   SMAD2↓, 1,   SMAD3↓, 3,   Snail?, 1,   Snail↓, 9,   Snail↑, 1,   TET1↑, 3,   TGF-β↓, 3,   TIMP1↑, 3,   TIMP2↓, 1,   TIMP2↑, 2,   TRIB3↑, 1,   TumCA↓, 1,   TumCI↓, 78,   TumCMig↓, 98,   TumCMig↑, 1,   TumCMig⇅, 1,   TumMeta↓, 28,   TumMeta↑, 3,   Twist↓, 7,   TXNIP↑, 1,   uPA↓, 2,   Vim?, 1,   Vim↓, 12,   Vim↑, 2,   Zeb1↓, 2,   α-SMA↓, 1,   α-SMA↑, 2,   β-catenin/ZEB1↓, 24,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 27,   angioG↑, 1,   CD31/PECAM-1↓, 1,   Endoglin↑, 2,   eNOS↓, 1,   HIF-1↓, 4,   Hif1a↓, 17,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 1,   VCAM-1↓, 1,   VEGF↓, 34,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 2,   BBB↑, 1,   BBB∅, 1,   CellMemb↓, 1,   EPR↑, 4,   GLUT1↓, 5,   MMP?, 1,   MMP↓, 105,   MMP↑, 2,   MMP∅, 1,   MPT↑, 5,   NHE1↓, 1,   SLC6A3?, 1,   sonoP↑, 2,   TRPM7↓, 3,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CCR7↓, 1,   CD4+↑, 6,   CD44↓, 4,   CD8+↑, 7,   cDC2↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 2,   DR4↑, 3,   FOXP3↑, 1,   Gal-3↓, 1,   HMGB1↓, 2,   IFN-γ↓, 2,   IL1↓, 1,   IL1↑, 1,   IL10↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 8,   IL1β↑, 1,   IL4↓, 1,   IL6↓, 21,   IL8↓, 4,   Imm↑, 10,   Inflam↓, 22,   MCP1/CCL2↓, 1,   MIP2↓, 1,   MyD88↑, 1,   NF-kB↓, 66,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 2,   NLRP3↑, 2,   p50↓, 1,   p65↓, 4,   p‑p65↓, 3,   PD-1↓, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PGE2↓, 5,   PSA↓, 2,   T-Cell↑, 1,   TCF↓, 2,   Th1 response↑, 1,   TLR4↓, 3,   TLR4↑, 1,   TNF-α↓, 16,   TNF-α↑, 5,   TRAF2↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   GGT/CD224↑, 1,   pH↓, 1,   pH↑, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 3,   CYP11A1↓, 1,   DHT↓, 1,   ER-α36↓, 2,   ER-α36↝, 1,   ERβ/ESR2↑, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   HSD3B↓, 1,   PPARγ↑, 6,   RANKL↓, 1,   SRD5A1↑, 1,   StAR↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 13,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↑, 85,   CompStab↓, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1B1↓, 1,   Dose?, 2,   Dose↓, 3,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 60,   Dose∅, 6,   eff?, 2,   eff↓, 75,   eff↑, 52,   eff⇅, 1,   eff↝, 5,   eff∅, 2,   Half-Life↓, 4,   Half-Life↝, 1,   MDR1↓, 2,   MDR1↑, 1,   MRP1/ABCC1↓, 1,   MRP5↓, 1,   P-gp/ABCB1↓, 8,   RadioS↑, 19,   selectivity?, 4,   selectivity↓, 2,   selectivity↑, 120,   selectivity∅, 1,   Synergy↑, 46,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AR↓, 3,   AST↓, 2,   BRCA1↓, 2,   BRCA1↑, 1,   CRP↓, 1,   EGFR↓, 19,   p‑EGFR↓, 2,   EstroRS/ERS↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 3,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 21,   KRAS↓, 4,   LDH↓, 5,   LDH↑, 6,   Myc↓, 2,   PD-L1↓, 5,   PD-L1↑, 1,   PSA↓, 2,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 37,   AntiCan⇅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 3,   AntiTum↑, 14,   AntiTum⇅, 1,   cardioP↑, 5,   chemoP↓, 1,   chemoP↑, 10,   chemoPv↑, 13,   ChemoSideEff↓, 2,   fatigue↓, 1,   FTO↓, 1,   hepatoP↑, 2,   Mucositis↓, 1,   neuroP↑, 5,   OS↑, 9,   Pain↓, 1,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 1,   Risk↓, 3,   Sleep↑, 1,   TGFβR1↓, 1,   toxicity↓, 16,   toxicity↝, 3,   toxicity∅, 1,   TumNum↓, 1,   TumVol↓, 34,   TumVol↑, 1,   TumVol∅, 1,   TumW↓, 17,   TumW∅, 1,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 8,  
Total Targets: 843

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 46,   Bil↓, 1,   Catalase↑, 14,   Fenton↓, 1,   GPx↑, 10,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 15,   GSR↑, 1,   GSTs↑, 6,   HO-1↓, 1,   HO-1↑, 7,   Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 11,   MDA↓, 9,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   Nrf1↑, 1,   NRF2↑, 13,   RNS↓, 2,   ROS↓, 32,   ROS↑, 5,   ROS⇅, 1,   ROS∅, 1,   SOD?, 1,   SOD↑, 13,   SOD1↑, 1,   TAC↑, 1,   TBARS↓, 1,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↓, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↓, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ALAT↓, 7,   AMPK↓, 1,   ATP↓, 1,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   Glycolysis↑, 1,   GSK‐3β↓, 1,   HK2↑, 1,   NAD↓, 1,   NADPH↓, 2,   PFKL↑, 1,   PFKM↑, 1,   PKM2↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   Apoptosis↑, 1,   BAX↓, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp3↓, 7,   Casp3↑, 1,   proCasp3↓, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 3,   Casp9↑, 1,   Cyt‑c↓, 2,   Fas↑, 1,   Ferroptosis↑, 1,   iNOS↓, 3,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   e-Akt↑, 1,   AMPKα↑, 1,   p‑CREB↑, 1,   ERK↑, 1,   e-ERK↑, 1,   IKKα↑, 1,   JAK2↑, 1,   PI3K↑, 1,   STAT↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   other↝, 3,   RUNX2↑, 1,   tumCV↓, 5,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 1,   P53↓, 1,   P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   GADD34↓, 1,   P21↓, 1,   P21↑, 3,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 1,   Ca+2↓, 1,   Cartilage↑, 1,   COL1↑, 1,   LRP1↑, 1,   MUC1↑, 1,   p‑Rac1↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCMig↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   GastroP↑, 1,   GLUT1↑, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 7,   FOXP3↑, 1,   HMGB1↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL10↓, 3,   IL10↑, 2,   IL17↓, 2,   IL1β↓, 6,   IL4↑, 1,   IL6↓, 8,   Imm↓, 1,   Imm↑, 2,   Inflam↓, 39,   Inflam↑, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 8,   NK cell↑, 1,   NLRP3↓, 3,   PGE2↓, 5,   PSA∅, 1,   RAGE↓, 1,   TNF-α↓, 12,   Treg lymp↝, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↓, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 2,   testos↑, 1,   VDR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 5,   BioAv↝, 3,   ChemoSen↑, 1,   CompStab↝, 1,   CYP2E1↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 6,   eff↓, 1,   eff↑, 6,   Half-Life↑, 1,   Half-Life↝, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALP↓, 3,   AST↓, 6,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 2,   CEA↓, 1,   creat↓, 1,   IL6↓, 8,   LDH↓, 1,   PSA∅, 1,   RAGE↓, 1,   SpO2↑, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↑, 5,   AntiDiabetic↑, 11,   antiNeop↑, 1,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP↑, 11,   chemoP↑, 5,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 2,   cough?, 1,   diuretic↑, 1,   hepatoP↑, 13,   memory↑, 3,   neuroP↑, 17,   Obesity↓, 3,   OS↑, 1,   Pain↓, 3,   RenoP↑, 2,   SoreThr?, 1,   Stress↓, 1,   toxicity↓, 21,   toxicity↑, 1,   toxicity↝, 6,   toxicity∅, 5,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 1,   AntiP↑, 3,   AntiViral↑, 3,   Bacteria↓, 8,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 241

Scientific Paper Hit Count for: tumCV, Cell Viability
22 Silver-NanoParticles
17 Quercetin
14 Cisplatin
14 Sulforaphane (mainly Broccoli)
14 Thymoquinone
12 Curcumin
11 Honokiol
10 doxorubicin
10 Licochalcone A
9 Dandelion Root
9 Fisetin
9 Kaempferol
9 Magnetic Fields
9 Methylsulfonylmethane
9 Phenethyl isothiocyanate
8 Betulinic acid
8 Marjoram (Origanum majorana)
7 SonoDynamic Therapy UltraSound
7 Berberine
7 Capsaicin
7 Carvacrol
7 Eugenol
7 Cynaropicrin
7 Gallic acid
7 Luteolin
7 Shikonin
6 Cynara scolymus/Globe Artichoke/Artichoke Extract
6 Allicin (mainly Garlic)
6 Radiotherapy/Radiation
6 Chrysin
6 Resveratrol
6 Emodin
6 Hyperoside
6 Ivermectin
6 Morin
5 Allyl isothiocyanate
5 Melatonin
5 5-fluorouracil
5 chaetocin
5 Crocetin
5 Formononetin
5 Ginkgetin
5 isoquercitrin
5 Licorice
5 Linalool
5 Matrine
5 Magnetic Field Rotating
5 Phycocyanin
5 Rosmarinic acid
4 Apigenin (mainly Parsley)
4 Metformin
4 Artemisinin
4 Baicalein
4 Berbamine
4 Biochanin A
4 Gemcitabine (Gemzar)
4 Benzyl isothiocyanate
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Chlorogenic acid
4 Carvone
4 Eurycomanone
4 Shilajit/Fulvic Acid
4 Graviola
4 Magnolol
4 iodine
4 Juglone
4 Lycopene
4 Terpinen-4-ol / Tea Tree Oil
4 Propolis -bee glue
4 α-Santalol/Sandalwood oil
4 Silymarin (Milk Thistle) silibinin
4 Vitamin C (Ascorbic Acid)
4 Vitexin
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 Beta-Caryophyllene
3 Carnosic acid
3 chitosan
3 Selenium
3 Citric Acid
3 CUSP9
3 Chlorella (Chlorella vulgaris)
3 Dichloroacetate
3 tamoxifen
3 Echinacea
3 eicosapentaenoic acid
3 Evodiamine
3 Fucoidan
3 Gambogic Acid
3 Hibiscus sabdariffa
3 Hyperthermia
3 HydroxyTyrosol
3 Methylene blue
3 mebendazole
3 Mushroom Chaga, Inonotus obliquus
3 Nimbolide
3 Piperlongumine
3 Plumbagin
3 Parthenolide
3 Selenite (Sodium)
3 Urolithin
2 3-bromopyruvate
2 Alpha-Lipoic-Acid
2 Anethole/trans-Anethole
2 Aloe anthraquinones
2 Bacopa monnieri
2 Boswellia (frankincense)
2 Beetroot
2 brusatol
2 Caffeic acid
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Coenzyme Q10
2 Polyphenols
2 Copper and Cu NanoParticles
2 Hydroxycinnamic-acid
2 Indole-3-carbinol
2 D-limonene
2 EGCG (Epigallocatechin Gallate)
2 Garcinol
2 Ginkgolic acids
2 Ginkgo biloba
2 Geraniol
2 Helleborus niger extracts – Christmas Rose
2 Rutin
2 Isoliquiritigenin
2 Isorhamnetin
2 isoorientin
2 Lasiodin
2 SDG/lignans
2 Lutein
2 Gold NanoParticles
2 Iron
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Mushroom Maitake
2 Naringin
2 Purple Corn / Purple Maize
2 Piperine
2 salinomycin
2 polyethylene glycol
2 Selenium NanoParticles
2 Chemotherapy
2 Photodynamic Therapy
2 Aflavin-3,3′-digallate
2 Ursolic acid
2 VitK3,menadione
2 Zerumbone
1 1,8-Cineole
1 Resiquimod
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 Bevacizumab (brand Avastin)
1 borneol
1 Boron
1 α-Bisabolol / Chamomile oil
1 Bullatacin
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 hydroxychloroquine
1 Catechins
1 Cannabidiol
1 Selenate
1 Vitamin E
1 Cranberry
1 Docosahexaenoic Acid
1 Diindolylmethane
1 Disulfiram
1 Ellagic acid
1 Cannabichromene
1 Ginkgo biloba-EGb 761
1 Electrical Pulses
1 Estrogen
1 Ferulic acid
1 Fenbendazole
1 Fennel Oil/Foeniculum vulgare
1 olaparib/LYNPARZA
1 Genistein (soy isoflavone)
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Hydrogen Gas
1 HydroxyCitric Acid
1 Paclitaxel/Taxol
1 Isobavachalcone
1 Inositol
1 MCT, metronomic chemo
1 capecitabine
1 Isothiocyanates
1 itraconazole
1 L-Theanine
1 Lactobacillus
1 lambertianic acid
1 Lapachol
1 Lemongrass Extract/Citral
1 Folic Acid, Vit B9
1 MBE, Maqui berry
1 gefitinib, erlotinib
1 Modified Citrus Pectin
1 irinotecan
1 Methyl Jasmonate
1 methylseleninic acid
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 immunotherapy
1 Magnesium
1 Mangiferin
1 magnetic nanoparticles
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Bicarbonate(Sodium)
1 Niclosamide (Niclocide)
1 Oleuropein
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Propyl gallate
1 Pterostilbene
1 Perilla
1 Scoulerine
1 Sesamin
1 acetazolamide
1 triptolide
1 Triphala
1 Turmerones
1 Vitamin D3
1 Vitamin K2
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:897  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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