AMPK Cancer Research Results

AMPK, adenosine monophosphate-activated protein kinase: Click to Expand ⟱
Source:
Type:
AMPK: guardian of metabolism and mitochondrial homeostasis; Upon changes in the ATP-to-AMP ratio, AMPK is activated. (AMPK) is a key metabolic sensor that is pivotal for the maintenance of cellular energy homeostasis. It is well documented that AMPK possesses a suppressor role in the context of tumor development and progression by modulating the inflammatory and metabolic pathways.

-Activating AMPK can inhibit anabolic processes and the PI3K/Akt/mTOR pathway reducing glycolysis shifting toward Oxidative Phosphorlylation.


AMPK activators:
-metformin or AICAR
-Resveratrol: activate AMPK indirectly
-Berberine
-Quercetin: may stimulate AMPK
-EGCG: thought to activate AMPK
-Curcumin: may activate AMPK

-Ginsenosides: Some ginsenosides have been associated with AMPK activation -Beta-Lapachone: A natural naphthoquinone compound found in the bark of Tabebuia avellanedae (also known as lapacho or taheebo). It has been observed to activate AMPK in certain models.
-Alpha-Lipoic Acid (ALA): associated with AMPK activation
Scientific Papers found: Click to Expand⟱
3612- RES,    Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential
- Review, AD, NA
*other↑, *Aβ↓, *Inflam↓, *NF-kB↓, *neuroP↑, *HO-1↑, *lipid-P↓, *COX2/PTGS2↓, *AMPK↑, *Catalase↑, *SOD↑, *GSR↑, *ROS↓, *MMP9↓, *cognitive↑, *SIRT1↑, *IL1β↓, *IL6↓,
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
Glycolysis↓, GLUT1↓, PFK1↓, Hif1a↓, ROS↑, PDH↑, AMPK↑, TumCG↓, TumCI↓, TumCP↓, p‑NF-kB↓, SIRT1↑, SIRT3↑, LDH↓, PI3K↓, mTOR↓, PKM2↓, R5P↝, G6PD↓, TKT↝, talin↓, HK2↓, GRP78/BiP↑, GlucoseCon↓, ER Stress↑, Warburg↓, PFK↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
2443- RES,    Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review
- Review, Var, NA
*antiOx↑, *ROS↓, *PTEN↑, *Akt↓, *Catalase↑, *SOD↑, *ERK↓, *GSH↑, *AMPK↑, *FOXO1↝, *RNS↓, *Catalase↑, *cardioP↑, *PI3K↑, *eNOS↑, hepatoP↑,
3080- RES,    Resveratrol: A miraculous natural compound for diseases treatment
- Review, Var, NA
SIRT1↑, ROCK1↓, AMPK↑, *lipid-P↓, Aβ↓, COX2/PTGS2↓, angioG↓, Hif1a↓, VEGF↓,
3100- RES,    Neuroprotective effects of resveratrol in Alzheimer disease pathology
- Review, AD, NA
*neuroP↑, *BioAv↓, *Half-Life↓, *BioAv↑, *BBB↑, *NRF2↑, *BioAv↓, *BioAv↑, *SIRT1↑, *cognitive↑, *lipid-P↓, *HO-1↑, *SOD↑, *GSH↑, *GPx↑, *G6PD↑, *PPARγ↑, *AMPK↑, *Aβ↓,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
3056- RES,    Less is more for cancer chemoprevention: evidence of a non-linear dose response for the protective effects of resveratrol in humans and mice
- in-vivo, Nor, NA
*AMPK↑, *P21↑, *Dose↓, *chemoPv↑,
3069- RES,    Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway
- in-vitro, Nor, N9
*antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *AMPK↑, *SIRT1↑, *miR-155↓, *NLRP3↓,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
1745- RosA,    Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
- Review, Var, NA - Review, AD, NA
ChemoSideEff↓, ChemoSen↑, antiOx↑, MMP2↓, MMP9↓, p‑AMPK↑, DNMTs↓, tumCV↓, COX2/PTGS2↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, Casp3↑, Casp9↓, ROS↓, GSH↑, ERK↓, Akt↓, ROS↓, NF-kB↓, p‑IκB↓, p50↓, p65↓, neuroP↑, Dose↝,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp/ABCB1↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
4735- SeNPs,    Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum
- in-vivo, Nor, NA
*MDA↓, *H2O2↓, *Catalase↑, *SOD↑, *GSTs↑, *GSH↑, *NRF2↓, *ATG3↓, *AMPK↓, *ROS↓,
3186- SFN,    A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet
- in-vivo, Nor, NA
*NLRP3↓, *ASC↓, *Casp1↓, *IL1β↓, *ALAT↓, *AST↓, *AMPK↑, *mTOR↓, *P70S6K↓,
2445- SFN,    Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCCA↑, P21↑, p27/CDKN1B↑, NO↑, Akt↓, ATP↓, AMPK↑, TumAuto↑, DNMT1↓, HK2↓, PKM2↓, HDAC3↓, HDAC4↓, HDAC8↓,
1471- SFN,    ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells
- in-vitro, GC, AGS
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↑, P21↑, p‑H3↑, p‑AMPK↑, eff↓, MMP↓, Cyt‑c↑, ROS↑, eff↓,
1479- SFN,    Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5'-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway
- in-vitro, CRC, HCT116
Ferroptosis↑, SIRT3↑, AMPK↑, mTOR↑, tumCV↓, ROS↑, MDA↑, Iron↑,
1723- SFN,    Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review
- Review, Var, NA
*NRF2↑, ROS↑, MMP↓, Cyt‑c↑, cl‑PARP↑, Apoptosis↑, AMPK↑, GSH↓,
4203- SIL,    Unlocking the Neuroprotective Potential of Silymarin: A Promising Ally in Safeguarding the Brain from Alzheimer’s Disease and Other Neurological Disorders
- Review, AD, NA
*MAPK↝, *AMPK↝, *NF-kB↓, *mTOR↝, *PI3K↝, *Akt↝, *BioAv↝, *memory↑, *BDNF↑, *TNF-α↓,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
2232- SK,    Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis
- in-vitro, ESCC, EC9706
tumCV↓, TumCMig↓, TumCI↓, TumAuto↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, AMPK↑, mTOR↑, TumVol↓, OS↑, LC3I↑,
2218- SK,    Shikonin Alleviates Endothelial Cell Injury Induced by ox-LDL via AMPK/Nrf2/HO-1 Signaling Pathway
- in-vitro, Nor, HUVECs
*Dose↝, *Apoptosis↓, *Casp3↓, *Bcl-2↑, *Inflam↓, *VCAM-1↓, *ICAM-1↓, *E-sel↓, *ROS↓, *SOD↑, *AMPK↑, *NRF2↑, *HO-1↑, *TNF-α↓, *IL1β↓, *IL6↓,
1193- SM,    Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways
- in-vivo, Alcohol, NA - in-vitro, Liver, HepG2
*p‑AMPK↑, *SIRT1↑, *NRF2↑, *CYP2E1↓, *lipoGen↓, *ROS↓, *Inflam↓,
7036- TBE,  GA,    Terminalia bellirica (Gaertn.) Roxb. Extract and Gallic Acid Attenuate LPS-Induced Inflammation and Oxidative Stress via MAPK/NF-κB and Akt/AMPK/Nrf2 Pathways
- in-vitro, Nor, THP1 - in-vitro, Nor, RAW264.7
*ROS↓, *MAPK↓, *NF-kB↓, *TAC↑, *NRF2↑, *Akt↑, *AMPK↑, *Inflam↓,
3401- TQ,    Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review
- Review, Var, NA
TumCP↓, *antiOx↑, *ROS↓, NRF2↑, NF-kB↓, TumCCA↑, *GABA↑, P53↑, P21↑, AMPK↑, neuroP↑, cardioP↑, hepatoP↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
- in-vitro, Var, NA
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
2350- UA,    Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,
119- UA,  CUR,  RES,    Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ROS⇅, p‑STAT3↓, Src↓, AMPK↑, GlutMet↑, TCA↑, glut↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *Synergy↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE/β-secretase↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1/ATG6↑, *ROS↓, *GutMicro↑, *Risk↓,
4862- Uro,    Neuroprotective effect of Urolithin A via downregulating VDAC1-mediated autophagy in Alzheimer's disease
- in-vivo, AD, NA - in-vitro, Nor, PC12
*cognitive↑, *p‑PI3K↓, *p‑Akt↓, *AMPK↑, *VDAC1↓, *neuroP↑, *PARK2↑, *PTEN↑, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p62↓, *Aβ↓, *Apoptosis↓,
4870- Uro,    Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
- in-vivo, AD, NA
*cognitive↑, *Apoptosis↓, *neuroP↑, *Aβ↓, *AMPK↑, *NF-kB↓, *MAPK↓, *BACE/β-secretase↑, *neuroG↑, *Inflam↓, *memory↑,
3141- VitC,    High-dose Vitamin C inhibits PD-L1 expression by activating AMPK in colorectal cancer
- in-vitro, CRC, HCT116
Glycolysis↓, Synergy↑, PD-L1↓, AMPK↑, HK2↓, NF-kB↓, Warburg↓, tumCV↓, GLUT1↓, PKM2↓, LDHA↓, CD4+↑, CD8+↑,
2366- VitD3,    Vitamin D3 decreases glycolysis and invasiveness, and increases cellular stiffness in breast cancer cells
- in-vitro, BC, MCF7
Glycolysis↓, tumCV↓, Apoptosis↑, mTOR↓, AMPK↑, EMT↓, E-cadherin↑, F-actin↑, Vim↓,
1818- VitK2,    New insights on vitamin K biology with relevance to cancer
- Review, Var, NA
TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,
7921- VT,    Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches
- in-vitro, Colon, Caco-2
Dose↝, tumCV↓, SOD↓, Catalase↓, MDA↑, P53↑, BAX↓, TSC2↑, SESN2↑, PUMA↑, AMPK↑, PI3K↑, Akt↑, mTOR↓,
7887- VT,  IVT,    Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,

Showing Research Papers: 201 to 241 of 241
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 241

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↓, 2,   Catalase↑, 1,   Fenton↑, 1,   GPx4↓, 4,   GSH↓, 5,   GSH↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 2,   HO-1↓, 4,   HO-1↑, 5,   Iron↑, 5,   i-Iron↓, 1,   lipid-P↑, 8,   MDA↑, 5,   i-MDA↑, 1,   MPO↓, 1,   NADH↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 5,   NRF2↑, 9,   Prx↓, 1,   ox-PrxI↑, 1,   RNS↑, 1,   ROS↓, 8,   ROS↑, 74,   ROS⇅, 3,   mt-ROS↑, 8,   SOD?, 1,   SOD↓, 2,   SOD↑, 1,   SOD2↓, 1,   TKT↝, 1,   Trx↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   NCOA4↑, 1,   Tf↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 5,   compI↓, 3,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   ETC↑, 1,   Insulin↓, 1,   MFN2↓, 1,   mitResp↓, 4,   mtDam↑, 8,   OCR↓, 4,   OCR↑, 1,   OXPHOS↓, 4,   OXPHOS↑, 2,   OXPHOS↝, 1,   mt-OXPHOS↑, 1,   PDH↓, 2,   PDH↑, 2,   PDH↝, 1,   PINK1↑, 2,   SIRT3↑, 3,   VDAC1↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↓, 5,   ACC↑, 5,   p‑ACC↑, 2,   p‑ACC-α↑, 1,   ACLY↓, 5,   adiP↑, 1,   AMP↑, 2,   AMPK?, 1,   AMPK↓, 6,   AMPK↑, 128,   AMPK↝, 2,   p‑AMPK↑, 20,   ATP↓, 17,   mt-ATP↓, 1,   CRM↑, 2,   ECAR↓, 3,   FAO↑, 1,   FASN↓, 9,   FDG↓, 1,   G6PD↓, 3,   GLS↓, 3,   glucoNG↓, 1,   glucose↓, 2,   GlucoseCon↓, 7,   GlucoseCon↑, 1,   glut↓, 1,   GlutaM↓, 1,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 23,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   HK2↓, 15,   HK2↑, 1,   lactateProd↓, 8,   lactateProd↑, 3,   LDHA↓, 6,   LDHA↑, 1,   LDL↓, 1,   lipidLev↓, 2,   lipoGen↓, 2,   NAD↓, 1,   NADH:NAD↓, 1,   NADPH↓, 4,   NPC1L1↓, 1,   PDK1 / PDPK1↓, 2,   PFK↓, 3,   PFK1↓, 1,   PKM2↓, 11,   PKM2↑, 1,   PPP↓, 2,   R5P↝, 1,   SCD1↓, 1,   SIRT1↓, 5,   SIRT1↑, 8,   SIRT2↓, 1,   SREBP1/SREBF1↓, 5,   SREBP2↓, 1,   TCA↓, 2,   TCA↑, 2,   Warburg↓, 11,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 3,   Apoptosis?, 1,   Apoptosis↑, 58,   ASC↑, 1,   BAD↓, 1,   BAD↑, 4,   Bak↑, 4,   BAX↓, 2,   BAX↑, 28,   Bax:Bcl2↑, 7,   Bcl-2↓, 37,   Bcl-xL↓, 11,   BID↓, 1,   BID↑, 4,   BIM↑, 3,   BNIP3↑, 2,   BOK↑, 1,   Casp↑, 10,   Casp1↓, 1,   Casp10↑, 1,   Casp3↓, 1,   Casp3↑, 36,   cl‑Casp3↑, 10,   Casp7↑, 4,   Casp8↑, 11,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 23,   cl‑Casp9↑, 1,   cFLIP↓, 4,   Cyt‑c↑, 26,   Cyt‑c↝, 1,   Diablo↑, 6,   DR5↑, 10,   FADD↑, 6,   Fas↓, 1,   Fas↑, 9,   FasL↑, 7,   Ferroptosis↑, 9,   IAP1↓, 2,   ICAD↓, 1,   iNOS↓, 4,   Mcl-1↓, 7,   Mcl-1↑, 1,   MDM2↓, 3,   MOMP↑, 1,   NAIP↓, 1,   p38↓, 1,   p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 12,   TRAIL↑, 2,   TumCD↑, 6,   XIAP↓, 7,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 46,   Akt↑, 5,   p‑Akt↓, 11,   p‑Akt↑, 1,   CaMKII ↑, 1,   CIP2A↓, 1,   cMET↓, 2,   CREB↓, 1,   EF-1α↓, 1,   EGFR↓, 12,   ERK↓, 12,   ERK↑, 3,   p‑ERK↓, 3,   IGF-1R↓, 1,   IKKα↓, 2,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK2↓, 3,   p‑JAK2↓, 1,   JNK↓, 1,   JNK↑, 10,   MAPK?, 1,   MAPK↓, 9,   MAPK↑, 4,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 1,   mTOR↓, 58,   mTOR↑, 11,   mTOR↝, 1,   mTOR∅, 1,   p‑mTOR↓, 6,   mTORC2↓, 1,   p70S6↓, 1,   p70S6↑, 1,   P70S6K↓, 5,   P70S6K↑, 1,   P90RSK↓, 1,   PDGFRA↓, 1,   PDGFRB↓, 1,   PI3K↓, 30,   PI3K↑, 5,   PI3K↝, 1,   p‑PI3K↓, 2,   PI3K/Akt↓, 1,   PKCδ↓, 2,   PP2A↑, 1,   PTEN↑, 5,   Raf↓, 1,   c-Raf↓, 1,   RAS↓, 2,   p‑S6K↓, 4,   Sp1/3/4↓, 3,   Src↓, 1,   STAT↓, 3,   STAT3↓, 24,   STAT3↑, 1,   p‑STAT3↓, 6,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 2,   TSC2↑, 2,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 4,   ChrMod↑, 1,   cJun↓, 4,   cJun↑, 1,   cMyc↓, 12,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMTs↓, 2,   FOXM1↓, 4,   FOXO↑, 1,   FOXO1↑, 1,   FOXO3↑, 1,   H3↑, 1,   p‑H3↑, 1,   H4↑, 1,   HATs↑, 1,   HDAC↓, 4,   HDAC∅, 1,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 3,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-122-5p↑, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-182-5p↓, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-206↑, 1,   miR-21↓, 2,   miR-21↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-29b↓, 1,   miR-326-5p↑, 1,   miR-34a↓, 1,   miR-34a↑, 3,   miR-34b-5p↑, 1,   miR-592↑, 1,   Myc↓, 3,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   OCT4↓, 3,   other↓, 3,   other↑, 1,   other↝, 3,   SOX2↓, 3,   SOX4↓, 2,   SOX9↓, 1,   TCF-4↓, 1,   tumCV↓, 24,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 4,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   ER Stress↑, 17,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 2,   HSP90↓, 5,   IRE1↑, 2,   PERK↑, 2,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   ATG7↑, 4,   autoF↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 3,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 10,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 6,   PARK2↑, 2,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 27,   p‑ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   DNAdam↑, 22,   DNArepair↓, 1,   NBR2↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 30,   p‑P53↓, 1,   p‑P53↑, 2,   PARP↓, 1,   PARP↑, 6,   cl‑PARP↑, 20,   cl‑PARP1↑, 1,   PCNA↓, 6,   Telomerase↓, 2,   TOP1↓, 2,   TOP2↓, 4,   TP53↑, 2,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 9,   CDK2↑, 2,   CDK4↓, 16,   CDK4↑, 2,   CDK6↓, 5,   CDK6↑, 2,   CDK7↓, 1,   Chk2↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 24,   cycE/CCNE↓, 7,   cycE/CCNE↑, 1,   cycE1↓, 1,   E2Fs↓, 2,   Ki-67↓, 8,   MAD↓, 1,   P21?, 1,   P21↓, 2,   P21↑, 15,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 6,   pRB↓, 1,   RB1↑, 2,   p‑RB1↓, 2,   Securin↓, 1,   TAp63α↑, 1,   TumCCA↓, 1,   TumCCA↑, 52,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↑, 1,   p‑4E-BP1↓, 1,   ALDH↓, 4,   BMI1↓, 2,   BMP7/OP1↓, 1,   CD133↓, 3,   CD133↑, 1,   CD24↓, 2,   cFos↓, 5,   CSCs?, 1,   CSCs↓, 16,   Diff↓, 1,   Diff↑, 2,   Gli1↓, 4,   HH↓, 3,   IGF-1↓, 4,   IGFBP1↑, 2,   Ki-67↓, 8,   Let-7↑, 2,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 4,   Nestin↓, 3,   NOTCH↓, 6,   NOTCH1↓, 3,   NOTCH3↓, 3,   Piezo1↑, 1,   PTCH1↓, 3,   Shh↓, 3,   Smo↓, 1,   Sufu↓, 1,   TumCG↓, 34,   TumCG↑, 1,   TumCP↓, 49,   TumCP↑, 1,   TumCP⇅, 1,   Wnt↓, 17,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 4,   ASAP2↓, 1,   Ca+2↑, 7,   CAFs/TAFs↝, 1,   cal2↓, 1,   DLC1↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 18,   EMT↓, 27,   EMT↑, 1,   EMT↝, 1,   F-actin↑, 1,   FAK↓, 3,   Fibronectin↓, 1,   Furin↓, 1,   GIT1↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   MALAT1↓, 2,   MET↓, 1,   MET↑, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 24,   MMP3↓, 2,   MMP7↓, 5,   MMP9↓, 27,   MMPs↓, 7,   N-cadherin↓, 10,   Rho↓, 2,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 4,   p‑SMAD2↓, 1,   Snail↓, 7,   talin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TIMP2↓, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI?, 1,   TumCI↓, 31,   TumCMig↓, 24,   TumMeta↓, 22,   TumMeta↑, 1,   Twist↓, 5,   TXNIP↓, 1,   uPA↓, 6,   Vim↓, 14,   Zeb1↓, 5,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 21,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 18,   angioG↑, 1,   CD31/PECAM-1↓, 1,   EGR4↓, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 21,   Hif1a↑, 2,   Hypoxia↓, 1,   LOX1↓, 1,   NO↑, 4,   PHDs↓, 1,   PHDs↑, 1,   TXA2↓, 1,   VEGF↓, 27,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 7,   GLUT1↑, 2,   GLUT2↓, 1,   GLUT3↓, 1,   MMP↓, 40,   MPT↑, 2,   TRPV1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 2,   CD44↓, 5,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 28,   CXCL1↓, 1,   CXCR4↓, 4,   DCells↑, 1,   DR4↑, 2,   DR4∅, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 4,   IL10↓, 1,   IL12↓, 2,   IL1β↓, 2,   IL2↓, 1,   IL2↑, 1,   IL6↓, 11,   IL6↑, 1,   IL8↓, 3,   Imm↑, 4,   Imm↝, 1,   Inflam↓, 7,   LRIG1↑, 1,   pol-M1↝, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 1,   NF-kB?, 1,   NF-kB↓, 40,   NF-kB↑, 3,   p‑NF-kB↓, 2,   NK cell↑, 1,   NLRP3↓, 1,   p50↓, 1,   p65↓, 4,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 6,   PGE2↓, 9,   PSA↓, 2,   TCF↓, 2,   TLR4↓, 1,   TNF-α↓, 8,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↑, 1,   Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   ER(estro)↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 10,   BioAv↑, 5,   BioAv↝, 4,   ChemoSen↑, 45,   ChemoSen⇅, 1,   CYP1B1↑, 1,   Dose?, 3,   Dose↓, 1,   Dose↑, 3,   Dose↝, 14,   Dose∅, 4,   eff↓, 21,   eff↑, 24,   eff↝, 6,   Half-Life↓, 3,   Half-Life↝, 5,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 6,   P450↓, 1,   RadioS↑, 20,   selectivity↑, 17,   Synergy↑, 28,   Synergy↝, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   BMD↑, 1,   EGFR↓, 12,   Ferritin↓, 1,   FOXM1↓, 4,   IL6↓, 11,   IL6↑, 1,   KRAS↓, 1,   LDH↓, 5,   p‑LDH↓, 1,   Myc↓, 3,   PD-L1↓, 6,   PSA↓, 2,   TG/TAG↓, 1,   TP53↑, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 11,   AntiCan⇅, 1,   antiNeop↑, 1,   AntiTum↑, 7,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 3,   chemoP↑, 5,   chemoPv↑, 7,   ChemoSideEff↓, 3,   hepatoP↑, 4,   neuroP↑, 6,   NP/CIPN↓, 1,   OS?, 1,   OS↑, 7,   OS⇅, 1,   OS∅, 1,   Pain↓, 2,   PFS∅, 1,   QoL↑, 3,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 7,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 3,   toxicity↝, 2,   toxicity∅, 1,   TumVol↓, 5,   TumW↓, 1,   Weight↑, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 658

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 45,   mt-antiOx↑, 1,   Catalase↑, 15,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 9,   GPx4↑, 2,   GSH↑, 25,   GSR↑, 1,   GSTs↑, 3,   H2O2↓, 2,   H2O2∅, 1,   HO-1↑, 20,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 19,   mt-lipid-P↓, 1,   lipidDe↓, 1,   MDA↓, 16,   MPO↓, 3,   NQO1↑, 5,   NRF2↓, 1,   NRF2↑, 36,   RNS↓, 1,   ROS↓, 68,   ROS↑, 1,   SOD↑, 22,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 3,   TOS↓, 1,   Trx1↑, 1,   TrxR1↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   Insulin↓, 4,   Insulin↑, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↓, 2,   OCR↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 7,   PINK1↑, 1,   SIRT3↑, 2,   TFAM↑, 1,   UCP1↓, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 2,   ACC↓, 1,   ACC↑, 1,   p‑ACC↑, 1,   Acetyl-CoA↓, 2,   adiP↓, 1,   adiP↑, 1,   ALAT↓, 13,   AMPK↓, 4,   AMPK↑, 77,   AMPK⇅, 1,   AMPK↝, 1,   p‑AMPK↑, 8,   ATP↓, 1,   ATP↑, 8,   cAMP↑, 1,   CRM↓, 1,   CRM↑, 4,   ECAR↓, 1,   ECAR↑, 1,   FAO↑, 4,   FASN↓, 1,   G6PD↑, 1,   glucoNG↓, 1,   glucose↓, 9,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 7,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↓, 1,   Glycolysis↑, 2,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   H2S↑, 1,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 4,   lipidLev↓, 2,   lipoGen↓, 1,   NAD↓, 1,   NADH:NAD↑, 1,   NADPH↓, 5,   NADPH↑, 1,   PDKs↓, 1,   PGM1?, 1,   PKM2↓, 2,   PKM2↑, 1,   SIRT1↑, 27,   SIRT1↝, 1,   SREBP1/SREBF1↓, 3,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 10,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 6,   BAX↑, 1,   Bcl-2↓, 3,   Bcl-2↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp3↓, 10,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp8↓, 1,   Casp9↓, 4,   cl‑Casp9↓, 1,   Cyt‑c↓, 3,   Cyt‑c∅, 1,   Fas↓, 2,   Ferroptosis↓, 4,   iNOS↓, 9,   necrosis↓, 1,   p38↓, 3,   p38↑, 1,   p‑p38↓, 2,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 5,   Akt↑, 9,   Akt↝, 1,   p‑Akt↓, 2,   p‑Akt↑, 2,   p‑CREB↑, 2,   ERK↓, 2,   ERK↑, 4,   p‑ERK↓, 1,   p‑ERK↑, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↓, 2,   JNK↓, 6,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAPK↓, 11,   MAPK↑, 2,   MAPK↝, 1,   mTOR↓, 12,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   p‑mTOR↑, 1,   P70S6K↓, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 5,   PI3K↝, 1,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↑, 2,   PP2A↑, 3,   PTEN↓, 2,   PTEN↑, 2,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   STAT5↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF2↑, 1,   ATF4↓, 2,   p‑cMyc↑, 1,   FOXO↑, 2,   FOXO1↝, 1,   FOXO3↑, 4,   miR-155↓, 1,   other↓, 1,   other↑, 2,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 4,   ER Stress↓, 4,   ER Stress↑, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   IRE1↓, 2,   NQO2↑, 1,   PDI↓, 1,   PERK↓, 1,   p‑PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 3,   MitoP↑, 2,   p62↓, 4,   p62↑, 1,   PARK2↑, 4,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,   P53↓, 3,   cl‑PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   GADD34↓, 1,   P21↓, 2,   P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   HH↓, 1,   HMGCR↓, 1,   IGF-1↓, 1,   mTORC1↓, 1,   neuroG↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Cartilage↑, 2,   COL1↓, 1,   COL1↑, 1,   MMP3↓, 2,   MMP9↓, 6,   PDGF↓, 1,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 3,   TGF-β↑, 2,   TGF-β1↓, 1,   TXNIP↓, 3,   α-SMA↓, 2,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 4,   E-sel↓, 1,   eNOS↑, 3,   Hif1a↓, 3,   NO↓, 7,   NO↑, 1,   VCAM-1↓, 4,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 10,   BBB↝, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 4,   H+/K+-ATPase↓, 1,   MMP↓, 1,   MMP↑, 11,   TRPC1↓, 1,   TRPV1↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 14,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IL10↓, 1,   IL10↑, 3,   IL17↓, 2,   IL18↓, 2,   IL1β↓, 17,   IL2↓, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 21,   IL8↓, 2,   Imm↓, 1,   Imm↑, 1,   Inflam↓, 61,   MCP1/CCL2↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↓, 1,   NF-kB↓, 33,   NLRP3↓, 18,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 7,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 1,   TLR4↓, 6,   TNF-α↓, 23,   TNF-α↑, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   Ach↑, 1,   AChE↓, 8,   ADAM10↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 10,   ChAT↑, 1,   GABA↑, 1,   NGF↑, 1,   TrkB↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 17,   BACE/β-secretase↓, 5,   BACE/β-secretase↑, 1,   tau↓, 1,   p‑tau↓, 9,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 4,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 15,   BioAv↝, 12,   BioEnh↑, 3,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 13,   eff↓, 1,   eff↑, 8,   eff↝, 1,   Half-Life↓, 4,   Half-Life↑, 1,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 13,   ALP↓, 2,   AST↓, 11,   BG↓, 1,   BloodF↑, 1,   BMD↑, 4,   BP↓, 5,   BP↝, 1,   BP∅, 1,   CRP↓, 3,   IL6↓, 21,   IRes↑, 1,   IRes↝, 1,   LDH↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 12,   antiAll↑, 6,   AntiCan↑, 4,   antiCG↑, 1,   AntiDiabetic↑, 9,   AntiTum↑, 2,   cardioP↑, 18,   chemoP↑, 2,   chemoPv↑, 4,   cognitive↑, 21,   diuretic↑, 1,   hepatoP↑, 23,   Learn↑, 1,   memory↑, 22,   motorD↑, 5,   neuroP↑, 47,   NP/CIPN↓, 1,   Obesity↓, 8,   OS↑, 4,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 3,   Strength↑, 4,   Stress↓, 1,   Stroke↓, 3,   toxicity↓, 15,   toxicity⇅, 1,   toxicity↝, 4,   toxicity∅, 2,   Weight↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 2,   AntiP↑, 1,   AntiViral↑, 2,   Bacteria↓, 4,   Diar↓, 1,   GutMicro↑, 11,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 407

Scientific Paper Hit Count for: AMPK, adenosine monophosphate-activated protein kinase
17 Resveratrol
14 Metformin
12 Berberine
10 Capsaicin
9 Alpha-Lipoic-Acid
8 Fisetin
7 Curcumin
6 EGCG (Epigallocatechin Gallate)
5 Baicalein
5 Hydrogen Gas
5 Sulforaphane (mainly Broccoli)
4 Artemisinin
4 Betulinic acid
4 Caffeic acid
4 diet Short Term Fasting
4 lambertianic acid
4 Morin
4 Quercetin
4 Urolithin
3 HydroxyCitric Acid
3 Aspirin
3 Ashwagandha(Withaferin A)
3 Chrysin
3 Calorie Restriction Mimetics
3 diet FMD Fasting Mimicking Diet
3 Emodin
3 Honokiol
3 Inositol
3 isoorientin
3 isoquercitrin
3 itraconazole
3 Kaempferol
3 Magnolol
3 Magnetic Field Rotating
3 Ursolic acid
2 2-DeoxyGlucose
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Baicalin
2 bempedoic acid
2 Boron
2 Boswellia (frankincense)
2 Chlorogenic acid
2 Gambogic Acid
2 Juglone
2 Luteolin
2 Methylene blue
2 Methyl salicylate / Sweet Birch oil
2 Magnetic Fields
2 Rosmarinic acid
2 Silymarin (Milk Thistle) silibinin
2 Shikonin
2 Thymoquinone
2 Vitamin K2
2 Vitexin
1 Astragalus
1 Andrographis
1 Radiotherapy/Radiation
1 Berbamine
1 Beta-Caryophyllene
1 Cannabidiol
1 Chemotherapy
1 Butyrate
1 Propolis -bee glue
1 Sorafenib (brand name Nexavar)
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Hydroxycinnamic-acid
1 Spermidine
1 Garcinol
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Dandelion Root
1 Ellagic acid
1 Ginkgolic acids
1 Ginkgo biloba
1 Hibiscus sabdariffa
1 Hyperoside
1 Isobavachalcone
1 Isoliquiritigenin
1 L-Theanine
1 Licochalcone A
1 Licorice
1 Lycopene
1 Matrine
1 MCT oil
1 doxorubicin
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Niclosamide (Niclocide)
1 Piperine
1 Pterostilbene
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Selenium NanoParticles
1 Salvia miltiorrhiza
1 Terminalia bellirica
1 Gallic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:9  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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