EMT Cancer Research Results

EMT, Epithelial-Mesenchymal Transition: Click to Expand ⟱
Source:
Type:
Biological process in which epithelial cells lose their cell polarity and cell-cell adhesion properties and gain mesenchymal traits, such as increased motility and invasiveness. This process is pivotal during embryogenesis and wound healing. Hh signaling pathway is able to regulate the EMT. Snail, E-cadherin and N-cadherin, key components of EMT; EMT-related factors, E-cadherin, N-cadherin, vimentin; The hallmark of EMT is the upregulation of N-cadherin followed by the downregulation of E-cadherin.
EMT is regulated by various signaling pathways, including TGF-β, Wnt, Notch, and Hedgehog pathways. Transcription factors such as Snail, Slug, Twist, and ZEB play critical roles in repressing epithelial markers (like E-cadherin) and promoting mesenchymal markers (like N-cadherin and vimentin).
EMT is associated with increased tumor aggressiveness, enhanced migratory and invasive capabilities, and resistance to apoptosis.
Scientific Papers found: Click to Expand⟱
7961- JG,    Juglone Inhibits Tumor Metastasis by Regulating Stemness Characteristics and the Epithelial-to-Mesenchymal Transition in Cancer Cells both in Vitro and in Vivo
- vitro+vivo, BC, MCF7 - in-vitro, BC, 4T1 - vitro+vivo, CRC, HCT116
EMT↓, CSCs↓, TumMeta↓, Pin1↓, TumCCA↑, angioG↓, Apoptosis↑, BAX↑, Bcl-2↓,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
8087- KAE,    Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways
- Review, Var, NA
TumCCA↓, ROS↝, Apoptosis↑, TumCP↑, TumMeta↓, angioG↓, PI3K↓, EMT↓, Snail↓, E-cadherin↓, N-cadherin↓, MMP2↓, Casp9↑, Casp7↑, PARP↑, Apoptosis↑, *ROS↓, Hif1a↓, p‑Akt↓, P53↑, cMyc↓, Glycolysis↓, PKM2↓, miR-339-5p↝, BioAv↓,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8095- KAE,    Kaempferol: A Key Emphasis to Its Anticancer Potential
- Review, Var, NA
*AntiBio↑, *Inflam↓, *AntiTum↓, *antiOx↑, *cardioP↑, *neuroP↑, *AntiDiabetic↑, Risk↓, TumCCA↑, EMT↓, PI3K↓, Akt↓, MMP2↓, Casp3↑, Casp7↑, Casp9↑, PARP↑, *ROS↓, angioG↓, *BioAv↑, BioAv↑, selectivity↑, GLUT1↓, MCT1↓, ROS↓, ROS↑, Trx↓, Cyt‑c↑, MMP↓, miR-21↓, SOCS-3↓, STAT3↓, CDK1↓, CycB/CCNB1↑, HIF-1↓, JAK1↑, PTEN↑,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8070- KAE,    Kaempferol: Paving the path for advanced treatments in aging-related diseases
- Review, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *NF-kB↓, *Akt↝, *β-catenin/ZEB1↝, *Aβ↓, *BDNF↑, Apoptosis↑, TumCCA↑, EMT↓, PI3K↓,
8075- KAE,  QC,    Systematic review on anticancer potential of Kaempferol and quercetin against lung, breast, and colorectal cancers with emphasis on in vitro and in vivo studies
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, P53↑, Bcl-2↓, PARP↑, ERK↓, IQGAP3↓, γH2AX↑, cl‑Casp3↑, cl‑Casp9↑, Rho↓, Rac1↓, MMP2↓, MMP9↓, CTSB↓, CTSD↓, O-Glc↓, SERPINH1/HSP47↓, EMT↓, angioG↓, EGF↓, VEGFR2/KDR/Flk1↓, RadioS↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8267- LE,    Glycyrrhizin Attenuates the Process of Epithelial-to-Mesenchymal Transition by Modulating HMGB1 Initiated Novel Signaling Pathway in Prostate Cancer Cells
- in-vitro, Pca, DU145
HMGB1↓, TumMeta↓, EMT↓,
1266- LE,    Glycyrrhizin suppresses epithelial-mesenchymal transition by inhibiting high-mobility group box1 via the TGF-β1/Smad2/3 pathway in lung epithelial cells
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B
HMGB1↓, EMT↓, TumCMig↓, p‑SMAD2↓, p‑SMAD3↓,
8143- LF,    Lactoferrin mediates epithelial-mesenchymal transformation by regulating the PI3K/AKT/mTOR pathway to inhibit nasopharyngeal carcinoma metastasis
- in-vitro, NPC, NA
TumCP↓, TumCI↓, TumCMig↓, EMT↓, NA?,
1122- LF,  MTX,    Lactoferrin Reverses Methotrexate Driven Epithelial Barrier Defect by Inhibiting TGF-β Mediated Epithelial to Mesenchymal Transition
- in-vivo, Colon, Caco-2
TGF-β↓, EMT↓,
8395- LT,  PacT,    Luteolin enhances drug chemosensitivity by downregulating the FAK/PI3K/AKT pathway in paclitaxel‑resistant esophageal squamous cell carcinoma
- in-vitro, ESCC, NA
*AntiTum↑, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, EMT↓, ChemoSen↑, PI3K↓, Akt↓, FAK↓,
8378- LT,    Luteolin and its derivatives: modulation of epithelial-mesenchymal transition in fibrosis and cancer
- Review, Var, NA
EMT↓, TGF-β1↓, Smad1↓, PI3K↓, Akt↓, Hippo↝, YAP/TEAD↓, *NRF2↑, *HO-1↑, *ROS↓, E-cadherin↑, ZO-1↑, Vim↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, TCF↓, Zeb1↓, angioG↓, eff↑, ROS↑, mtDam↑, MMP↓, ETC↓,
8377- LT,    Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases
- Review, Asthma, NA
*PI3K↑, *Akt↑, *Inflam↓, *ROS↓, *BioAv↓, *RenoP↑, *cardioP↑, *neuroP↑, *antiAll↑, *AntiDiabetic↑, *hepatoP↑, *AntiThr↑, *toxicity↓, *IL10↓, *Sepsis↓, *TNF-α↓, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *lipid-P↓, *IL4↓, *IL5↓, *PGE2↓, *PI3K↑, *Akt↑, *mTOR↑, *Beclin-1/ATG6↓, *Mucositis↓, *PLA2↓, STAT3↓, PD-L1↓, miR-34a↓, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Bax:Bcl2↑, Apoptosis↑, ROS↑, EMT↓, E-cadherin↓, DR5↑, LIMK1↓, Pain↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8393- LT,    Progress, pharmacokinetics and future perspectives of luteolin modulating signaling pathways to exert anticancer effects: A review
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, EMT↓, Imm↝, ChemoSen↑, *Inflam↓, *COX2/PTGS2↓, *NF-kB↓, MMP2↓, MMP9↓, p‑Akt↓, p‑PI3K↓, IGF-2↓, IGF-1R↓, CXCL16↓, NOTCH1↓, HES1↓, VEGF↓, ROS↑,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,
8371- LT,    Study on the regulatory mechanism of luteolin inhibiting WDR72 on the proliferation and metastasis of non small cell lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Nor, BEAS-2B
TumCP↓, TumCI↓, TumCMig↓, TumVol↓, p‑Akt↓, Apoptosis↓, EMT↓, Dose↝, Akt↓, WDR72↓, TumMeta↓,
1100- LT,    Luteolin, a flavonoid, as an anticancer agent: A review
- Review, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, ROS↑, ER Stress↑, mtDam↑, p‑eIF2α↝, p‑PERK↝, p‑CHOP/DDIT3↝, p‑ATF4↝, cl‑Casp12↝,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
4687- LT,  QC,    Dietary Flavonoids Luteolin and Quercetin Suppressed Cancer Stem Cell Properties and Metastatic Potential of Isolated Prostate Cancer Cells
- in-vitro, Pca, DU145
CSCs↓, EMT↓, MMPs↓, TumCMig↓, TumCI↓,
8348- Lut,    Lutein inhibits proliferation, invasion and migration of hypoxic breast cancer cells via downregulation of HES1
- in-vitro, BC, MCF7 - in-vitro, BC, MDA‑MB‑157
TumCP↓, Apoptosis↑, Hif1a↓, NOTCH↓, HES1↓, EMT↓, TumCI↓, TumCMig↓, ROS↓,
1714- Lyco,    Lycopene reduces ovarian tumor growth and intraperitoneal metastatic load
- in-vitro, Ovarian, OV-MZ-6 - in-vivo, NA, NA
ChemoSen↑, CA125↓, ITGA5↓, ITGB1↓, MMP9↓, FAK↓, EMT↓, MAPK↓, MMP9↓, antiOx↑, Ki-67↓, MAPK↓,
1126- Lyco,    Lycopene Inhibits Epithelial–Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway
- vitro+vivo, Oral, NA
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, PI3K↓, Akt↓, mTOR↓, E-cadherin↓, BAX↑, N-cadherin↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, Bcl-2↓,
4795- Lyco,    Updates on the Anticancer Profile of Lycopene and its Probable Mechanism against Breast and Gynecological Cancer
- Review, BC, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↝, BAX↝, cycD1/CCND1↓, ERK↓, Akt↓, STAT3↓, NRF2↝, NF-kB↓, ITGB1↓, ITGA5↓, FAK↓, MMP9↓, EMT↓,
8500- MAG,    Magnolol Induces Apoptosis Through Extrinsic/intrinsic Pathways and Attenuates NF-κB/STAT3 Signaling in Non-small-cell Lung Cancer Cells
- in-vitro, NSCLC, A549
NF-kB↓, STAT3↓, EMT↓,
8505- MAG,    Role of magnolol in gastrointestinal cancers: Recent trends and future perspectives
- Review, GC, NA
TumCP↓, TumCI↓, TumCMig↓, angioG↓, EMT↓, TumCCA↑, Apoptosis↑, PI3K↝, Akt↝, NF-kB↝, MAPK↝, JNK↝, ERK↝, TGF-β↝, Smad1↝,
4520- MAG,    Magnolol Suppresses Pancreatic Cancer Development In Vivo and In Vitro via Negatively Regulating TGF-β/Smad Signaling
- vitro+vivo, PC, PANC1
Vim↓, E-cadherin↑, EMT↓, N-cadherin↓, p‑SMAD2↓, p‑SMAD3↓, TumCP↓, TumCMig↓, TumCI↓, TGF-β↓,
8563- Matr,    Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition
- in-vitro, BC, MDA-MB-231
TumCP↓, Apoptosis↑, EMT↓, ITGB1↓,
8530- Matr,    Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition
- in-vitro, HCC, NA
TumCP↓, TumCMig↓, TumCI↓, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, EMT↓, PIP3↑, PTEN↑, p‑Akt↓,
8529- Matr,    Matrine targets β-catenin and blocks the formation of β-catenin/TCF7L2 complex to promote ferroptosis and inhibit metastasis in triple-negative breast cancer
- in-vitro, BC, NA
β-catenin/ZEB1↓, Wnt↓, TCF7/TCF1↓, GPx4↝, Ferroptosis↑, EMT↓,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8550- Matr,    Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/β-catenin signaling pathway
- vitro+vivo, Liver, HUH7
other↝, Wnt↓, β-catenin/ZEB1↓, EMT↓, TumCMig↓, TumCI↓, Inflam↓, hepatoP↑, AST?, ALB↑, ALAT↓, ALP↓, GGT/CD224↓, TBIL↓, DBIL↓, IBIL↓,
8628- MBZ,    Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H460
TumCP↓, TumCMig↓, Apoptosis↑, ROS↑, p‑JAK2↓, p‑STAT3↓, eff↓, TumCG?, Bcl-xL↓, EMT↓, Snail↓, Twist↓,
8786- mCHEMO,    Metronomic chemotherapy in cancer treatment: new wine in an old bottle
- Review, Var, NA
eff↑, ChemoSideEff↓, angioG↓, *toxicity↓, PFS↑, Hif1a↓, TumCD↑, CSCs↓, EMT↓, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, CD133↓, TumCCA↑, P21↓, DNAdam↑, Imm↑, Synergy↑, Synergy↑,
2384- MET,    Integration of metabolomics and transcriptomics reveals metformin suppresses thyroid cancer progression via inhibiting glycolysis and restraining DNA replication
- in-vitro, Thyroid, BCPAP - in-vivo, NA, NA - in-vitro, Thyroid, TPC-1
Glycolysis↓, OXPHOS↑, tumCV↓, TumCI↓, TumCMig↓, EMT↓, Apoptosis↑, TumCCA↑, LDHA↓, PKM2↓, IDH1↑, TumCG↓,
2378- MET,    Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1α/PKM2/STAT3 pathway
- in-vitro, SCC, CAL27 - in-vivo, NA, NA
TumCP↓, TumCMig↓, TumCI↓, EMT↓, mTOR↓, Hif1a↓, PKM2↓, STAT3↓, E-cadherin↑, Vim↓, Snail↓, STAT3↓,
2377- MET,    Metformin Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition via PKM2 Relative-mTOR/p70s6k Signaling Pathway in Cervical Carcinoma Cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa
EMT↓, P70S6K↓, mTOR↓, PKM2↓, Warburg↓, AMPK↑,
2376- MET,    Metformin Inhibits Epithelial-to-Mesenchymal Transition of Keloid Fibroblasts via the HIF-1α/PKM2 Signaling Pathway
- in-vitro, Nor, NA
*Hif1a↓, *EMT↓, *p‑P70S6K↓, *PKM2↓,
2386- MET,    Mechanisms of metformin inhibiting cancer invasion and migration
- Review, Var, NA
OS↑, AMPK↑, EMT↓, TGF-β↓, mTOR↓, P70S6K↓, PKM2↓, Hif1a↓, ChemoSen↑,
2371- MET,    The role of pyruvate kinase M2 in anticancer therapeutic treatments
- Review, Var, NA
ChemoSen↑, PKM2↓, Hif1a↓, EMT↓,
8483- MF,    Magnetic Fields in Cancer Therapy: Mechanistic Insights, Signaling Pathways, and Evidence from Clinical and In Vitro Studies
- Review, Var, NA
Apoptosis↑, TumCP↓, Ferroptosis↑, TumCMig↓, EMT↓, ROS↝, ChemoSen↑, RadioS↑, Telomerase↓, selectivity↑, ROS↑, DNAdam↑, Casp↑, Ca+2↑, MMP↓, lysoMP↑, lipid-P↑, NA↑, other↑, ChemoSen↑, P53↑,
8662- MLT,    Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis
- vitro+vivo, Bladder, 5637 - in-vitro, CRC, T24/HTB-9 - in-vitro, HNSCC, UM-SCC-1
Glycolysis↓, ENO1↓, ROS↑, TumCP↓, TumMeta↓, TumCCA↑, Casp3↑, BIM↑, Bcl-2↓, γH2AX↑, EMT↓, N-cadherin↓, MMP9↓, Snail↓, Akt↓, eff↓, TumVol↓, PPARγ↓,
8683- MLT,    Intra-tumor ROS amplification by melatonin interferes in the apoptosis-autophagy-inflammation-EMT collusion in the breast tumor microenvironment
- in-vivo, BC, NA
ROS↑, SIRT1↑, IL6↓, STAT3↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, tumCV↓, JNK↑, P53↑, Bax:Bcl2↑, cl‑Casp3↑, Apoptosis↑, eff∅, TumAuto↑, EMT↓, Half-Life↓, CompStab↓, BioAv↓, Dose↝, TumW↓, TumVol↓, Ki-67↓, PTEN↑,

Showing Research Papers: 201 to 250 of 366
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 366

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 7,   Catalase↓, 7,   ENOX2↓, 1,   Fenton↑, 1,   frataxin↑, 1,   GPx↓, 3,   GPx1↓, 1,   GPx4↓, 8,   GPx4↝, 1,   GSH↓, 21,   GSH↑, 4,   GSH/GSSG↓, 1,   GSR↓, 2,   GSR↑, 1,   ox-GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 8,   HO-1↑, 13,   Iron↑, 3,   c-Iron↑, 1,   Keap1↑, 1,   lipid-P↓, 2,   lipid-P↑, 8,   MDA↓, 1,   MDA↑, 4,   NQO1?, 1,   NQO1↓, 3,   NQO1↑, 4,   NRF2↓, 20,   NRF2↑, 14,   NRF2↝, 1,   PYCR1↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 20,   ROS↑, 140,   ROS⇅, 4,   ROS↝, 2,   i-ROS↓, 1,   mt-ROS↑, 2,   selenoP↑, 1,   SOD↓, 11,   SOD↑, 3,   SOD1↓, 3,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 2,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 2,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   STEAP3↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 6,   CDC25↓, 6,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   EGF↓, 6,   ETC↓, 3,   Insulin↓, 1,   mitResp↓, 4,   mitResp↑, 1,   Mortalin↓, 1,   mtDam↑, 13,   OCR↓, 4,   OXPHOS↓, 1,   OXPHOS↑, 2,   mt-OXPHOS↓, 1,   PDH↝, 1,   SIRT3↓, 1,   SIRT3↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   AApath↓, 1,   ACADS/SCAD↓, 1,   ACC↑, 1,   ACLY↓, 1,   p‑ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 4,   AMPK↓, 1,   AMPK↑, 22,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 15,   mt-ATP↓, 1,   CAIX/CA9↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FABP4↑, 1,   FASN↓, 2,   GAPDH↓, 1,   glucoNG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 9,   GlutMet↓, 1,   Glycolysis↓, 27,   GSK‐3β↓, 9,   GSK‐3β↑, 2,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 8,   HK1↓, 1,   HK2↓, 11,   HMG-CoA↓, 4,   IDH1↑, 1,   lactateProd↓, 9,   LDHA↓, 4,   LDL↓, 1,   lipoGen↓, 1,   NAD↓, 1,   NADPH↓, 4,   NADPH↑, 1,   O-Glc↓, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PDKs↓, 1,   PFK↓, 1,   PFK1↓, 1,   PIP3↑, 1,   PKM2↓, 15,   PKM2↑, 1,   RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,   SIRT1↓, 10,   SIRT1↑, 4,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   TCA↓, 1,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 3,   Apoptosis↓, 6,   Apoptosis↑, 124,   mt-Apoptosis↑, 1,   ASC↓, 1,   ASC↑, 1,   BAD↓, 1,   BAD↑, 3,   Bak↑, 7,   BAX↓, 1,   BAX↑, 59,   BAX↝, 1,   Bax:Bcl2↑, 16,   Bcl-2↓, 69,   Bcl-2↑, 1,   Bcl-xL↓, 18,   Bcl-xL↑, 1,   BID↑, 4,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 6,   BNIP3↑, 2,   BOK↑, 1,   Casp↑, 17,   Casp1↓, 3,   Casp10↑, 1,   Casp12↑, 1,   cl‑Casp12↑, 2,   cl‑Casp12↝, 1,   Casp3↓, 3,   Casp3↑, 71,   cl‑Casp3↑, 16,   Casp6↑, 1,   Casp7↑, 15,   Casp8↑, 14,   cl‑Casp8↑, 2,   Casp9↓, 1,   Casp9↑, 45,   cl‑Casp9↑, 5,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↓, 2,   Cyt‑c↑, 42,   mt-Cyt‑c↓, 1,   Diablo↑, 4,   DR5↑, 19,   Endon↑, 1,   FADD↑, 4,   Fas↓, 1,   Fas↑, 15,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 13,   GSDMD↑, 1,   HEY1↓, 1,   IAP1↓, 5,   IAP2/BIRC3↓, 1,   IAP2/BIRC3↑, 1,   iNOS↓, 5,   Mcl-1?, 1,   Mcl-1↓, 15,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 7,   MDM2↑, 2,   p‑MDM2↓, 1,   NAIP↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↓, 5,   p38↑, 9,   p‑p38↓, 2,   p‑p38↑, 1,   PUMA↓, 1,   PUMA↑, 2,   Pyro↑, 2,   RIP1↑, 1,   RIP3↑, 1,   survivin↓, 32,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD↓, 1,   TumCD↑, 5,   TUNEL↑, 1,   XIAP↓, 19,   YAP/TEAD↓, 4,   YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 109,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 30,   AKT1↓, 2,   Akt2↓, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 3,   cSrc↓, 1,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 28,   ERK↑, 7,   ERK↝, 1,   p‑ERK↓, 10,   ERK5↑, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↑, 1,   Hippo↝, 1,   IGF-1R↓, 1,   IKKα↓, 7,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↓, 1,   p‑IκB↓, 1,   JAK↓, 3,   p‑JAK↓, 1,   JAK1↓, 2,   JAK1↑, 1,   JAK2↓, 6,   p‑JAK2↓, 3,   p‑JAK3↓, 1,   JNK↓, 5,   JNK↑, 12,   JNK↝, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   LIMK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 28,   MAPK↑, 9,   MAPK↝, 1,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 4,   MKK4↓, 1,   mTOR↓, 63,   mTOR↝, 1,   p‑mTOR↓, 6,   mTORC2↓, 2,   p70S6↓, 1,   P70S6K↓, 2,   P90RSK↓, 2,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 94,   PI3K↝, 1,   p‑PI3K↓, 7,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   PKA↓, 1,   PKCδ↓, 5,   PTEN↓, 2,   PTEN↑, 19,   Raf↓, 4,   c-Raf↓, 1,   RAS↓, 4,   RET↓, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 12,   Src↓, 3,   p‑Src↓, 1,   STAT↓, 2,   p‑STAT2↓, 1,   STAT3↓, 54,   STAT3↑, 1,   STAT3↝, 1,   p‑STAT3↓, 12,   p‑STAT3↑, 2,   STAT6↓, 1,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 10,   p‑ATF4↝, 1,   CBP↓, 1,   cJun↓, 7,   cJun↑, 1,   cMyc↓, 29,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 5,   DNMTs↓, 2,   EZH2↓, 6,   FOXM1↓, 3,   FOXO1↓, 3,   FOXO3↓, 2,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 2,   H3↓, 2,   H3↑, 2,   ac‑H3↑, 2,   H3K27ac↓, 1,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 3,   HDAC↓, 14,   HDAC1↓, 3,   HDAC10↓, 1,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC4↓, 2,   HES1↓, 3,   HOTAIR↓, 1,   miR-107↑, 1,   miR-10a-5p↝, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-141↑, 1,   miR-145↑, 1,   miR-155↓, 1,   miR-155↝, 1,   miR-19b↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   miR-205↑, 1,   miR-21↓, 4,   miR-21↑, 1,   miR-218↑, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-29b↑, 1,   miR-301a-3p↓, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↓, 3,   miR-34a↑, 4,   miR-34a↝, 1,   miR-34b-5p↑, 1,   miR-384↑, 2,   miR-422a↑, 1,   MTA2↓, 1,   Myc↓, 2,   n-MYC↓, 1,   NDRG1↑, 1,   OCT4↓, 18,   other↓, 3,   other↑, 4,   other↝, 6,   PAX2↓, 1,   PhotoS↑, 1,   SOX2↓, 9,   SOX4↓, 4,   SOX9?, 1,   SOX9↓, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV↓, 31,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 16,   p‑CHOP/DDIT3↝, 1,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 3,   p‑eIF2α↑, 4,   p‑eIF2α↝, 1,   ER Stress↑, 32,   GRP78/BiP↓, 2,   GRP78/BiP↑, 12,   HSF1↓, 1,   HSP27↓, 6,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 1,   HSP90↓, 11,   IRE1↑, 5,   PDI↑, 1,   PERK↑, 7,   p‑PERK↝, 1,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↓, 1,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 9,   CTSB↓, 2,   CTSD↓, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3B-II↑, 2,   LC3II↓, 2,   LC3II↑, 10,   LC3s↓, 1,   lysoMP↑, 1,   p62↓, 3,   p62↑, 2,   SESN2↑, 1,   TumAuto↑, 28,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DFF45↑, 2,   DNAdam↑, 33,   DNArepair↓, 1,   ERCC1↓, 1,   ERCC3↑, 1,   m-FAM72A↓, 1,   hTERT/TERT↓, 9,   MGMT↓, 1,   p16↑, 2,   P53?, 1,   P53↓, 1,   P53↑, 55,   P53↝, 1,   p‑P53↑, 1,   ac‑P53↑, 1,   p53 Wildtype↑, 1,   p53 Wildtype∅, 1,   PARP↓, 1,   PARP↑, 15,   cl‑PARP↑, 25,   PARP1↑, 2,   PCNA↓, 21,   PCNA↑, 1,   POLD1↓, 1,   SIRT6↓, 1,   Telomerase↓, 9,   TOP1?, 1,   TOP1↓, 6,   TOP2↓, 4,   TP53↑, 2,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↑, 7,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 9,   CDK1↑, 1,   CDK2↓, 25,   CDK2↑, 2,   CDK4↓, 29,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK6↓, 10,   CDK6↑, 1,   CDK8↓, 1,   CDKN1C/p57↑, 1,   CHK1↓, 1,   p‑CHK1↑, 1,   Chk2↓, 1,   p‑Chk2↑, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 14,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 48,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 9,   E2Fs↓, 1,   Ki-67↓, 22,   MAD↓, 1,   P21?, 1,   P21↓, 3,   P21↑, 33,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 14,   pRB↓, 1,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   TumCCA↓, 4,   TumCCA↑, 105,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 7,   ALDH1A1↓, 6,   AXIN1↓, 1,   AXIN1↑, 1,   BMI1↓, 1,   BMP2↓, 1,   BMPs↑, 1,   CD133↓, 15,   CD133↑, 1,   CD24↓, 1,   CD34↓, 1,   CDX2↓, 1,   CEBPB↓, 1,   cFos↓, 7,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 69,   CSCsMark↓, 2,   Diff↓, 2,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 2,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 13,   GREM1↓, 1,   HH↓, 15,   HH↝, 1,   IGF-1↓, 1,   IGF-2↓, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   Ki-67↓, 22,   Let-7↓, 1,   Let-7↑, 2,   LRP6↓, 3,   p‑LRP6↓, 1,   MSCmark↓, 1,   mTORC1↓, 4,   p‑mTORC1↓, 1,   Nanog↓, 17,   Nestin↓, 3,   NICD↓, 1,   NKD2↑, 1,   NOTCH↓, 18,   NOTCH↑, 1,   NOTCH1↓, 18,   NOTCH1↑, 3,   NOTCH1↝, 1,   NOTCH3↓, 3,   p300↓, 2,   Pirin↓, 1,   PTCH1↓, 4,   PTCH2↓, 1,   SFRP5↑, 1,   Shh↓, 13,   Smo↓, 6,   p‑STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG?, 2,   TumCG↓, 62,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 112,   TumCP↑, 3,   tyrosinase↓, 1,   WDR72↓, 1,   Wnt↓, 44,   Wnt/(β-catenin)↓, 7,  

Migration(tgid=13) ⓘ

ACTA2↓, 1,   AEG1↓, 2,   AEG1↑, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 7,   AP-1↝, 1,   AXL↓, 2,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 21,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 2,   cal2↑, 1,   Cdc42↓, 1,   Chl↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL1A1↓, 1,   COL3A1↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 19,   E-cadherin↑, 123,   EM↑, 2,   EMT?, 1,   EMT↓, 349,   EMT↑, 7,   EMT↝, 2,   EpCAM↓, 1,   F-actin↓, 2,   F-actin↑, 1,   FAK↓, 16,   FAK↑, 1,   p‑FAK↓, 3,   fascin↓, 1,   Fibronectin↓, 11,   Galectin-9↓, 1,   GIT1↓, 1,   GLI2↓, 3,   IQGAP3↓, 1,   ITGA5↓, 2,   ITGA5↑, 1,   ITGB1↓, 7,   ITGB1↑, 1,   ITGB3↓, 1,   ITGB6↓, 1,   LAMA5↑, 1,   LAMs↓, 2,   LEF1↓, 4,   MALAT1↓, 4,   MET↓, 2,   MET↑, 1,   p‑MET↓, 2,   MMP-10↓, 2,   MMP1↓, 4,   MMP13↓, 3,   MMP16↓, 2,   MMP2↓, 97,   MMP2↝, 1,   MMP3↓, 6,   MMP7↓, 7,   MMP9↓, 99,   MMP9↑, 2,   MMP9↝, 1,   MMPs↓, 28,   MUC1↑, 1,   MUC4↓, 1,   N-cadherin↓, 87,   PAK1↓, 1,   p‑pax↓, 1,   PDGF↓, 5,   PIR↓, 1,   Rac1↓, 3,   RHBDD1↓, 1,   Rho↓, 6,   ROCK1↓, 9,   Slug?, 1,   Slug↓, 41,   Smad1↓, 4,   Smad1↝, 1,   SMAD2↓, 5,   p‑SMAD2↓, 10,   SMAD3↓, 7,   p‑SMAD3↓, 8,   SMAD4↓, 2,   Snail?, 2,   Snail↓, 75,   Snail↑, 2,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 31,   TGF-β↑, 1,   TGF-β↝, 1,   TGF-β1↓, 3,   TIMP1↑, 6,   TIMP2↓, 2,   TIMP2↑, 2,   TRIB3↑, 2,   TSP-1↑, 4,   TumCA↓, 2,   TumCI↓, 128,   TumCI↑, 3,   TumCMig↓, 129,   TumCMig↑, 3,   TumMeta↓, 77,   TumMeta↑, 5,   Twist↓, 30,   Twist↑, 2,   Tyro3↓, 1,   uPA↓, 22,   uPAR↓, 2,   Vim?, 1,   Vim↓, 103,   Vim↑, 3,   Zeb1↓, 32,   Zeb1↑, 2,   ZEB2↓, 2,   ZEB2↑, 2,   α-SMA↓, 3,   α-SMA↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 65,   β-catenin/ZEB1↑, 2,   p‑β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 64,   angioG↑, 2,   CD31/PECAM-1↓, 3,   eNOS↓, 3,   HIF-1↓, 5,   Hif1a↓, 49,   Hif1a↑, 1,   Hif1a↝, 1,   NO↓, 1,   NO↑, 1,   NO↝, 1,   TXA2↓, 1,   VEGF↓, 76,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 14,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 4,   CLDN1↓, 6,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN7↑, 1,   EPR↑, 1,   GLUT1↓, 6,   GLUT2↓, 1,   MMP↓, 62,   MMP↑, 1,   MPT↑, 4,   NHE1↓, 1,   TRPV2↑, 1,   ZO-1↓, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↓, 1,   CD4+↓, 2,   CD4+↑, 1,   CD44↓, 18,   CD8+↑, 4,   COX1↓, 2,   COX2/PTGS2↓, 47,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL12↓, 4,   CXCL16↓, 1,   CXCR4↓, 10,   DR4↑, 3,   FOXP3↑, 1,   FoxP3+↓, 1,   HMGB1↓, 6,   ICAM-1↓, 2,   IFN-γ↓, 2,   IFN-γ↑, 2,   Igs↑, 1,   IL1↓, 4,   IL10↓, 4,   IL12↓, 1,   IL12↑, 1,   IL18↓, 2,   IL1β↓, 13,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL6↓, 32,   IL6↑, 1,   IL8↓, 7,   Imm↑, 9,   Imm↝, 3,   Inflam↓, 22,   IRAK1↓, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   NF-kB↓, 101,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 3,   p50↓, 1,   p65↓, 6,   p65↑, 1,   p‑p65↓, 5,   PD-1↓, 4,   PD-L1↓, 9,   PD-L2↓, 1,   PGE2↓, 19,   PSA↓, 4,   RAGE↓, 1,   SOCS-3↓, 1,   T-Cell↑, 1,   TCF↓, 5,   TCF7/TCF1↓, 2,   Th1 response↑, 1,   TILs↑, 1,   TIM-3↓, 1,   TLR4↓, 3,   TNF-α↓, 23,   TNF-α↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,   IM↓, 1,   pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

MAOA↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↓, 2,   AR↓, 12,   ER-α36↓, 1,   ER-α36↝, 1,   FGF21↓, 1,   PPARα↓, 1,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B10↓, 1,   BioAv↓, 26,   BioAv↑, 26,   BioAv↝, 7,   ChemoSen↓, 1,   ChemoSen↑, 111,   ChemoSen⇅, 1,   CompStab↓, 2,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   Dose?, 1,   Dose↓, 3,   Dose↑, 4,   Dose↝, 19,   Dose∅, 6,   DrugR↓, 1,   eff↓, 15,   eff↑, 38,   eff↝, 6,   eff∅, 2,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 8,   Half-Life↑, 1,   Half-Life↝, 7,   Half-Life∅, 1,   MDR1↓, 7,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 15,   P450↓, 4,   RadioS↑, 37,   selectivity?, 1,   selectivity↑, 38,   Synergy↑, 83,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   ALAT↓, 4,   ALB↑, 1,   ALP↓, 3,   AR↓, 12,   AST?, 1,   AST↓, 2,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CA125↓, 1,   CEA↓, 1,   CRP↓, 2,   DBIL↓, 1,   E6↓, 3,   E7↓, 3,   EGFR↓, 31,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 6,   Ferritin↓, 2,   FOXM1↓, 3,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 9,   IBIL↓, 1,   IL6↓, 32,   IL6↑, 1,   IRes↓, 1,   LDH↓, 5,   LDH↑, 3,   Maspin↑, 1,   Myc↓, 2,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 4,   RAGE↓, 1,   TBIL↓, 1,   TG/TAG↓, 1,   TP53↑, 2,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 24,   antiNeop↑, 1,   AntiTum↓, 2,   AntiTum↑, 15,   cachexia↓, 2,   cardioP↑, 6,   chemoP?, 1,   chemoP↑, 11,   chemoPv↑, 10,   ChemoSideEff↓, 4,   fatigue↓, 1,   hepatoP↑, 6,   neuroP↑, 5,   OS↑, 12,   Pain↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 3,   radioP↑, 2,   RenoP↑, 4,   Risk↓, 6,   Symptoms∅, 1,   toxicity?, 1,   toxicity↓, 8,   toxicity↑, 4,   toxicity↝, 7,   toxicity∅, 2,   TumVol↓, 15,   TumW↓, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 958

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 43,   Catalase↑, 18,   DPPH↓, 1,   GPx↓, 1,   GPx↑, 13,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 16,   GSR↑, 2,   GSTs↑, 7,   HDL↓, 1,   HDL↑, 1,   HO-1?, 1,   HO-1↑, 8,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 11,   MDA↓, 13,   MDA↑, 1,   MPO↓, 2,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 20,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 56,   SOD↓, 1,   SOD↑, 18,   SOD1↑, 2,   SOD2↑, 2,   TAC↑, 1,   TrxR↑, 1,   uricA↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 3,   ATP↓, 1,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   LDHA↑, 1,   LDL↓, 2,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   PKM2↓, 1,   PLA2↓, 1,   SIRT1↑, 4,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↓, 1,   Casp↓, 1,   Casp3?, 1,   Casp3↓, 4,   Casp9↓, 2,   Cyt‑c↓, 2,   Ferroptosis↓, 1,   iNOS↓, 4,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 1,   mTOR↓, 1,   mTOR↑, 2,   p‑mTOR↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 1,   PI3K↑, 4,   PTEN↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 1,   p‑cMyc↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other↝, 2,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4,   LC3II↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   Ki-67↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Ki-67↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   COL1↓, 3,   COL1↑, 1,   COL3A1↓, 1,   E-cadherin↑, 4,   EMT↓, 7,   EMT↑, 2,   Fibronectin↓, 1,   MMP13↓, 2,   MMP2↓, 1,   MMP9↓, 2,   Smad7↑, 2,   Snail↑, 1,   TGF-β↓, 3,   TGF-β1↓, 1,   TIMP1↓, 1,   TregCell↑, 1,   Twist↑, 1,   Vim↓, 4,   Vim↑, 1,   α-SMA↓, 6,   β-catenin/ZEB1↓, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   Hif1a↓, 2,   NO↓, 4,   NO↑, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   MMP↑, 3,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 10,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL10↓, 3,   IL10↑, 1,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 12,   IL2↓, 1,   IL2↑, 1,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 2,   IL6↓, 14,   IL8↓, 3,   Imm↓, 1,   Imm↑, 3,   Inflam?, 2,   Inflam↓, 43,   IRF3↓, 1,   LPS↓, 1,   MCP1/CCL2↓, 1,   MyD88↓, 1,   NF-kB↓, 17,   NLRP3↓, 2,   PGE2↓, 8,   RAGE↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 5,   TNF-α↓, 17,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 9,   BACE/β-secretase↓, 2,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,   PPARα↝, 1,   p‑PPARγ↓, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 24,   BioAv↑, 8,   BioAv↝, 3,   CYP2E1↓, 1,   Dose↑, 1,   Dose↝, 3,   eff↑, 3,   GSTA1↑, 1,   Half-Life↝, 6,   Half-Life∅, 1,   P450↓, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   AST↓, 7,   BMD↑, 1,   BP↓, 1,   BUN↓, 1,   creat↓, 1,   CRP↓, 2,   IL6↓, 14,   LDH↓, 2,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 5,   AntiArt↑, 2,   AntiCan↑, 5,   AntiDiabetic↑, 10,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 19,   chemoP↑, 2,   chemoPv↑, 5,   cognitive↑, 4,   diuretic↑, 1,   hepatoP↑, 19,   Learn↑, 1,   memory↑, 6,   motorD↑, 1,   Mucositis↓, 2,   neuroP↑, 34,   Obesity↓, 2,   PDE4↓, 1,   radioP↑, 2,   RenoP↑, 5,   Stroke↓, 2,   toxicity↓, 15,   toxicity↑, 1,   toxicity↝, 4,   toxicity∅, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 4,   GutMicro↑, 5,   GutMicro↝, 1,   Sepsis↓, 2,  
Total Targets: 244

Scientific Paper Hit Count for: EMT, Epithelial-Mesenchymal Transition
19 Curcumin
17 Resveratrol
16 Quercetin
13 Honokiol
13 Luteolin
10 Sulforaphane (mainly Broccoli)
9 Ashwagandha(Withaferin A)
9 EGCG (Epigallocatechin Gallate)
9 Fisetin
9 Thymoquinone
7 Kaempferol
6 Astragalus
6 Berberine
6 Matrine
6 Metformin
6 Piperine
6 Rosmarinic acid
5 Apigenin (mainly Parsley)
5 Betulinic acid
5 Chrysin
5 Emodin
5 Eugenol
5 Silymarin (Milk Thistle) silibinin
4 Alpha-Lipoic-Acid
4 Baicalein
4 Propolis -bee glue
4 Chlorogenic acid
4 Diindolylmethane
4 Inositol
4 Morin
4 Pterostilbene
4 Shikonin
3 Artemisinin
3 Atorvastatin
3 5-fluorouracil
3 Cyclopamine
3 salinomycin
3 Genistein (soy isoflavone)
3 Ferulic acid
3 Fucoidan
3 Garcinol
3 HydroxyTyrosol
3 Lycopene
3 Magnolol
3 Melatonin
3 Nimbolide
3 Piperlongumine
3 Urolithin
2 Anethole/trans-Anethole
2 Cisplatin
2 Astaxanthin
2 Beta-Caryophyllene
2 brusatol
2 Capsaicin
2 Cannabidiol
2 Celecoxib
2 Centella asiatica / Gotu kola → asiaticoside
2 Crocetin
2 Radiotherapy/Radiation
2 Deguelin
2 Dandelion Root
2 Disulfiram
2 Ellagic acid
2 Sorafenib (brand name Nexavar)
2 Paclitaxel/Taxol
2 Ginkgetin
2 Grapeseed extract
2 phytic acid, Inositol hexakisphosphate
2 Isoliquiritigenin
2 isoflavones
2 isoorientin
2 isoquercitrin
2 Ivermectin
2 Juglone
2 Licorice
2 Lactoferrin/Talactoferrin
2 Naringin
2 Phenethyl isothiocyanate
2 Vitamin C (Ascorbic Acid)
2 Vitamin D3
2 VitK3,menadione
1 1,8-Cineole
1 Anthocyanins
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Aspirin
1 Baicalin
1 Berbamine
1 Biochanin A
1 Brucea javanica
1 Boron
1 Carnosic acid
1 Caffeic acid
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cucurbitacin
1 Oxaliplatin
1 Dichloroacetate
1 Docosahexaenoic Acid
1 immunotherapy
1 Copper and Cu NanoParticles
1 Ginkgo biloba-EGb 761
1 Eurycomanone
1 Cinnamon
1 Evodiamine
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Ginkgolide B
1 Proanthocyanidins
1 Hydrogen Gas
1 Chemotherapy
1 Hydroxycinnamic-acid
1 Hyperoside
1 Isovitexin
1 methotrexate
1 Lutein
1 mebendazole
1 MCT, metronomic chemo
1 Magnetic Fields
1 Lemon Balm/Melissa officinalis
1 Myricetin
1 Niclosamide (Niclocide)
1 Oleocanthal
1 Plumbagin
1 Psoralidin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Selenium
1 Selenate
1 Gemcitabine (Gemzar)
1 Selenite (Sodium)
1 statins
1 Citric Acid
1 Terpinen-4-ol / Tea Tree Oil
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Vitamin K2
1 Vitexin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:96  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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