IL1β Cancer Research Results

IL1β, interleukin-1 beta: Click to Expand ⟱
Source:
Type:
The term "IL-1" is often used as an umbrella term for the interleukin-1 family, which includes multiple cytokines. The two best-known members are IL-1α and IL-1β.
IL-1β is secreted from cells and plays a major systemic role in inflammation. It is a crucial mediator in the inflammatory response and is involved in the fever response, activation of endothelial cells, and leukocyte recruitment.
Its increased expression is commonly linked to:
  – Promotion of a pro-inflammatory microenvironment that supports tumor growth.
  – Enhanced angiogenesis, invasion, and metastasis.
  – Recruitment of myeloid cells that may further suppress antitumor immunity.

High expression of either tends to be associated with a more aggressive phenotype and worse prognosis in many cancer types.
Scientific Papers found: Click to Expand⟱
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3570- TQ,    Thymoquinone alleviates the experimentally induced Alzheimer's disease inflammation by modulation of TLRs signaling
- in-vivo, AD, NA
*Inflam↓, *Aβ↓, *TNF-α↓, *IL1β↓, *TLR2↓, *IRF3↓, *TLR4↓, *memory↑, *NF-kB↓, *MyD88↓, *TRIF↓, *BBB↑, *cognitive↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,
5934- TV,    Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties
- Review, Var, NA
*Inflam↓, *antiOx↑, *Bacteria↓, AntiTum↑, *toxicity∅, *IBI↑, *ZO-1↑, *OCLN↑, *COX1↑, *TLR4↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *TAC↑, *NRF2↑, *GutMicro↑,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *eff↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑,
4877- Uro,    Urolithin-A Derivative UAS03 Improves Cognitive Deficits and Memory by Activating Nrf2 Pathways to Alleviate Oxidative Stress and Neuroinflammation
- in-vivo, AD, NA
*cognitive↑, *memory↑, *neuroP↑, *NRF2↑, *ROS↓, *Inflam↓, *IL1β↓, *TNF-α↓, *COX2↓,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
4838- Uro,    The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
- Review, Var, NA
BioAv↑, Inflam↓, IL6↓, IL1β↓, NOS2↓, p53 Wildtype↑, MDM2↑, Snail↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓, mTOR↓, p‑Akt↓, selectivity↑, EMT↓,
4311- VitB1/Thiamine,    Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *ROS↓, *cognitive↑, *OS↑, *Mood↑, *neuroP↑, *Inflam↓, *NRF2↑, *PGC-1α↑, *AGEs↓, *4-HNE↓, *NQO1↑, *COX2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *GSK‐3β↓,
4330- VitB5,    Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *ATP↑, *G6PD↑, *NADPH↑, *IL1β↓, *other↝,
596- VitC,    High-Dose Vitamin C in Advanced-Stage Cancer Patients
- Review, NA, NA
ChemoSideEff↓, ROS↑, H2O2↑, Fenton↑, Hif1a↝, Dose↑, BioAv↓, Dose↝, Half-Life↝, IL1β↓, IL2↓, IL8↓, TNF-α↓,
3127- VitC,    Vitamin C inhibits the activation of the NLRP3 inflammasome by scavenging mitochondrial ROS
- in-vitro, Nor, NA - in-vivo, Nor, NA
*NLRP3↓, *AIM2↓, *mt-ROS↓, *IL1β↓,
3131- VitC,    Antioxidant Vitamin C attenuates experimental abdominal aortic aneurysm development in an elastase-induced rat model
- in-vivo, Nor, NA
*MMP2↓, *MMP9↓, *TNF-α↓, *IL1β↓, *TIMP2↑, *TIMP1↓, *antiOx↑, *Inflam↓,
2368- VitD3,    Vitamin D3 supplementation shapes the composition of gut microbiota and improves some obesity parameters induced by high-fat diet in mice
- in-vivo, Obesity, NA
*Weight↓, *TNF-α↓, *IL1β↓, LPS↓, *ZO-1↑, *GutMicro↑,
2277- VitK2,    Vitamin K2 suppresses rotenone-induced microglial activation in vitro
- in-vitro, Nor, BV2 - NA, AD, NA - NA, Park, NA
*p38↓, *ROS↓, *Casp1↓, *MMP↑, *NF-kB↓, *IL1β↓, *iNOS↓, *COX2↓, *TNF-α↓,
4191- Zeax,  Lut,    Effects of macular xanthophyll supplementation on brain-derived neurotrophic factor, pro-inflammatory cytokines, and cognitive performance
- Trial, AD, NA
*BDNF↑, *IL1β↓, *cognitive↑, *memory↑,

Showing Research Papers: 201 to 217 of 217
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 217

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 1,   H2O2↑, 1,   ROS↓, 1,   ROS↑, 2,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↑, 3,   Casp3↑, 1,   MDM2↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   p53 Wildtype↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 2,   ERK↓, 1,   mTOR↓, 1,   PI3K↓, 2,   RAS↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   Hif1a↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 1,   LPS↓, 1,   NF-kB↓, 3,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   IL6↓, 2,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   ChemoSideEff↓, 1,   toxicity↓, 1,  
Total Targets: 57

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

4-HNE↓, 1,   antiOx↑, 5,   Catalase↑, 2,   Ferroptosis↓, 1,   GPx↑, 1,   GSH↑, 2,   GSTs↑, 1,   H2O2↓, 1,   HO-1↑, 1,   lipid-P↓, 3,   MDA↓, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 6,   PARK2↑, 2,   ROS↓, 6,   mt-ROS↓, 1,   SOD↑, 2,   TAC↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 2,   MMP↑, 3,   PGC-1α↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 1,   G6PD↑, 1,   LDH↓, 1,   NADPH↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 1,   BAX↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp1↓, 1,   Casp3↓, 1,   Casp3↑, 1,   Ferroptosis↓, 1,   iNOS↓, 2,   iNOS↑, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Autophagy & Lysosomes ⓘ

MitoP↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   mTOR↓, 1,   neuroG↑, 1,   PI3K↓, 1,  

Migration ⓘ

Cartilage↑, 2,   MMP2↓, 1,   MMP9↓, 2,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCP↓, 1,   ZO-1↑, 2,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,   IBI↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling ⓘ

AIM2↓, 1,   COX1↑, 1,   COX2↓, 6,   CRP↓, 2,   IFN-γ↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 14,   IL6↓, 4,   Inflam↓, 11,   MyD88↓, 3,   NF-kB↓, 7,   TLR2↓, 3,   TLR4↓, 4,   TNF-α↓, 10,   TRIF↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BDNF↑, 1,   p‑tau↓, 3,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 5,   BACE↓, 1,   NLRP3↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   Dose↝, 1,   eff↑, 3,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

CRP↓, 2,   GutMicro↑, 3,   IL6↓, 4,   LDH↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 3,   cognitive↑, 5,   hepatoP↑, 1,   memory↑, 5,   Mood↑, 1,   motorD↑, 1,   neuroP↑, 6,   OS↑, 2,   radioP↑, 1,   RenoP↑, 3,   Risk↓, 1,   Strength↑, 2,   toxicity∅, 1,   Weight↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   IRF3↓, 3,  
Total Targets: 115

Scientific Paper Hit Count for: IL1β, interleukin-1 beta
18 Thymoquinone
12 Sulforaphane (mainly Broccoli)
10 Propolis -bee glue
9 Quercetin
8 Curcumin
8 Lycopene
7 Hydrogen Gas
7 Magnetic Fields
7 Silymarin (Milk Thistle) silibinin
6 Alpha-Lipoic-Acid
6 Resveratrol
6 Shikonin
5 Silver-NanoParticles
5 Urolithin
4 Ashwagandha(Withaferin A)
4 Baicalein
4 Berberine
4 Chrysin
4 Honokiol
4 Rosmarinic acid
3 Carvacrol
3 Celastrol
3 Chlorogenic acid
3 Ferulic acid
3 Fisetin
3 Luteolin
3 Piperine
3 Rutin
3 Vitamin C (Ascorbic Acid)
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Artemisinin
2 Baicalin
2 Betulinic acid
2 borneol
2 Boron
2 Boswellia (frankincense)
2 Butyrate
2 Capsaicin
2 Thymol-Thymus vulgaris
2 EGCG (Epigallocatechin Gallate)
2 Phosphatidylserine
2 5-fluorouracil
2 Chemotherapy
2 Melatonin
2 Phenylbutyrate
2 Piperlongumine
2 Pterostilbene
1 Anthocyanins
1 alpha Linolenic acid
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 Selenium
1 Bruteridin(bergamot juice)
1 Carnosic acid
1 Carnosine
1 chitosan
1 Ginkgo biloba
1 Ginseng
1 Cisplatin
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Vitamin B3,Niacin
1 Naringin
1 Oleuropein
1 Oleocanthal
1 Psoralidin
1 Radiotherapy/Radiation
1 Perilla
1 Selenium NanoParticles
1 Sesame seeds and Oil
1 acetaminophen
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 Vitamin K2
1 Zeaxanthin
1 Lutein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:978  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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