| 3636- | Cro, | Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies |
| - | in-vitro, | AD, | NA |
| 3624- | Cro, | Crocus Sativus L. (Saffron) in Alzheimer's Disease Treatment: Bioactive Effects on Cognitive Impairment |
| - | Review, | AD, | NA |
| 3625- | Cro, | Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial |
| - | Trial, | AD, | NA |
| 3626- | Cro, | Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trial |
| - | Trial, | AD, | NA |
| 3627- | Cro, | The effects of Crocus sativus (saffron) and its constituents on nervous system: A review |
| - | Review, | AD, | NA | - | Review, | Stroke, | NA |
| 3628- | Cro, | VitE, | CUR, | Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 3629- | Cro, | Studying saffron nanopowder (Crocus Sativus L.) on the temporal memory of rats suffering Parkinson's disease |
| - | in-vivo, | Park, | NA |
| 3630- | Cro, | Crocin Improves Cognitive Behavior in Rats with Alzheimer's Disease by Regulating Endoplasmic Reticulum Stress and Apoptosis |
| - | in-vivo, | AD, | NA |
| 3631- | Cro, | Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease |
| - | in-vitro, | AD, | HT22 | - | in-vivo, | AD, | NA |
| 3634- | Cro, | A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease |
| - | Trial, | AD, | NA |
| 3635- | Cro, | A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures |
| - | Review, | NA, | NA |
| 3637- | Cro, | Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment |
| - | NA, | AD, | NA |
| 3832- | Cro, | Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 4158- | Cro, | Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus |
| - | in-vivo, | AD, | NA |
| 945- | Cro, | Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer |
| - | in-vitro, | Lung, | A549 | - | in-vitro, | Cerv, | HeLa |
| 6291- | Cro, | Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model |
| - | vitro+vivo, | PC, | MIA PaCa-2 | - | vitro+vivo, | PC, | Bxpc-3 | - | vitro+vivo, | PC, | Capan1 | - | vitro+vivo, | PC, | AsPC-1 |
| 6316- | Cro, | Crocin suppresses prostate cancer progression via TLR4/NF-κB and NLRP3 pathway inhibition |
| - | vitro+vivo, | Pca, | LNCaP | - | in-vitro, | Pca, | 22Rv1 |
| 6315- | Cro, | Functional Mechanisms of Dietary Crocin Protection in Cardiovascular Models under Oxidative Stress |
| - | in-vivo, | NA, | NA |
| 6314- | Cro, | Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway |
| - | in-vitro, | GC, | NA |
| 6313- | Cro, | Crocetin and related oxygen diffusion‐enhancing compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications |
| - | Review, | Covid, | NA | - | Review, | Var, | NA | - | Review, | Stroke, | NA |
| 6312- | Cro, | Crocin from Crocus Sativus Possesses Significant Anti-Proliferation Effects on Human Colorectal Cancer Cells |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | SW48 | - | in-vitro, | CRC, | HT29 |
| 6311- | Cro, | Intestinal Metabolism of Crocin and a Pharmacokinetics and Pharmacodynamics Study in the Chronic Social Defeat Stress Mouse Model |
| - | in-vivo, | Nor, | NA |
| 6310- | Cro, | Characterization of Crocetin Isomers in Serum Samples via UHPLC-DAD-MS/MS and NMR after Saffron Extract (Safr’Inside™) Consumption |
| - | in-vivo, | Nor, | NA |
| 6309- | Cro, | Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway |
| - | in-vitro, | CRC, | HCT116 |
| 6308- | Cro, | Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage |
| - | vitro+vivo, | PC, | Bxpc-3 |
| 6307- | Cro, | Effects of Intestinal Microbiota on Pharmacokinetics of Crocin and Crocetin in Male Sprague-Dawley Rats |
| - | in-vivo, | Nor, | NA |
| 6306- | Cro, | Crocetin induces apoptosis of BGC-823 human gastric cancer cells |
| - | in-vitro, | GC, | BGC-823 |
| 6305- | Cro, | Bridging Preclinical and Clinical Evidence on Crocin in Breast Cancer |
| - | Review, | BC, | NA |
| 6304- | Cro, | Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ |
| - | in-vitro, | BC, | NA |
| 6334- | Cro, | Eug, | Rad, | Crocin and eugenol enhance radiosensitivity in oral squamous cell carcinoma cells via apoptotic pathways and cell cycle regulation. Type of study: in vitro |
| - | in-vitro, | OS, | NA |
| 6303- | Cro, | Crocetin treatment inhibits proliferation of colon cancer cells through down-regulation of genes involved in the inflammation |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | DU145 |
| 6302- | Cro, | Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases |
| - | Review, | NA, | NA |
| 6301- | Cro, | Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways |
| - | vitro+vivo, | Colon, | HT29 | - | in-vitro, | Colon, | Caco-2 |
| 6300- | Cro, | Interaction of saffron and its constituents with Nrf2 signaling pathway: A review |
| - | Review, | Nor, | NA | - | Review, | Arthritis, | NA |
| - | in-vivo, | Nor, | NA |
| 6298- | Cro, | Crocetin Prevents RPE Cells from Oxidative Stress through Protection of Cellular Metabolic Function and Activation of ERK1/2 |
| - | in-vitro, | AMD, | RPE-1 |
| 6297- | Cro, | Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-κB/iNOS Pathway and Nrf2/HO-1 Pathway |
| - | in-vitro, | Nor, | RAW264.7 |
| 6296- | Cro, | Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats |
| - | in-vivo, | Nor, | NA |
| 6295- | Cro, | Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract |
| - | Human, | Nor, | NA |
| 6294- | Cro, | Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention |
| - | Review, | Var, | NA |
| 6293- | Cro, | Crocetin: an agent derived from saffron for prevention and therapy for cancer |
| - | Review, | Var, | NA |
| 6292- | Cro, | Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53-dependent and -independent mechanisms |
| - | in-vitro, | Cerv, | HeLa | - | in-vitro, | Lung, | A549 | - | in-vitro, | Ovarian, | SKOV3 |
| 4208- | Cro, | Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus |
| - | in-vivo, | NA, | NA |
| 6522- | CRV, | l-carvone decreases breast cancer cells adhesion, migration, and invasion by suppressing FAK activation |
| - | in-vivo, | Var, | NA |
| 6521- | CRV, | L-carvone induces p53, caspase 3 mediated apoptosis and inhibits the migration of breast cancer cell lines |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | Nor, | MCF10 |
| 6527- | CRV, | Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events |
| - | in-vivo, | Melanoma, | NA |
| 6520- | CRV, | Health Benefits and Pharmacological Properties of Carvone |
| - | Review, | Nor, | NA |
| 6523- | CRV, | Anticancer effects of Carvone in myeloma cells is mediated through the inhibition of p38 MAPK signalling pathway, apoptosis induction and inhibition of cell invasion |
| - | NA, | Melanoma, | NA |
| 6524- | CRV, | d-Carvone inhibits the JAK/STAT3 signaling pathway and induced the apoptotic cell death in the human gastric cancer AGS cells |
| - | in-vitro, | GC, | AGS |
| 6525- | CRV, | D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4) |
| - | in-vitro, | AML, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:% State#:% Dir#:%
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