Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
827- GAR,    Garcinol Is an HDAC11 Inhibitor
- in-vitro, NA, NA
HDAC11↓,
826- GAR,    Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
- vitro+vivo, HCC, HepG2 - vitro+vivo, Liver, HUH7
STAT3↓, TumCP↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCCA↑, TumVol↓,
793- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC9 - in-vitro, SCC, SCC4 - in-vitro, SCC, SCC25
TumCG↓, Apoptosis↑, TumCCA↑, NF-kB↓, COX2↓, VEGF↓,
794- GAR,    Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
- in-vitro, RCC, NA - in-vitro, Lung, A549 - in-vitro, Nor, NA
DR5↑, cFLIP↓, *toxicity↓,
795- GAR,    Garcinol—A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, NA, NA
HATs↓, BAX↑, PARP↑, Bcl-2↓, Casp3↑, Casp9↑, DR5↑, cFLIP↓, MMP2↓, MMP9↓, STAT3↓, p‑Akt↓,
797- GAR,  CUR,    Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
- in-vitro, BC, MCF-7 - in-vitro, OS, U2OS - in-vitro, OS, SaOS2
TumCP↓, H3K18↓, DNAdam↑,
1636- GAR,    Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation
- Case Report, Obesity, NA
*Dose∅, *other↑,
1632- GAR,    Garcinia Cambogia, Either Alone or in Combination with Green Tea Causes Moderate to Severe Liver Injury
- Human, LiverDam, NA
HLA↑, other↑,
1190- Gb,    Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model
- in-vivo, CRC, SW-620
TumMeta↑, Ki-67↑,
1189- Gb,    New insight into the mechanisms of Ginkgo biloba leaves in the treatment of cancer
- Review, NA, NA
Apoptosis↑, TumCP↓, TumCI↓, TumCMig↓, Inflam↓, antiOx↑, angioG↓,
1188- Gb,    The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2-mediated antioxidant protection
- Review, NA, NA
*NRF2↑, *ROS↓,
1187- Gb,    Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase
- in-vitro, Melanoma, U251 - in-vitro, Melanoma, MM.1S
STAT3↓, PTEN↑, Apoptosis↑, PTPN6↑,
1186- Gb,    Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis
- in-vitro, PC, NA - in-vitro, Nor, HUVECs - in-vivo, PC, NA
tumCV↓, *toxicity∅, TumCMig↓, TumCI↓, Apoptosis↑, AMPK↑, lipoGen↓, ACC↓, FASN↓,
4245- Gb,    Standardized extract of Ginkgo biloba enhances memory persistence over time
- in-vivo, NA, NA
*memory↑, *BDNF↑,
4244- Gb,    Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men
- Human, Nor, NA
*BDNF∅,
1117- Gb,    Ginkgobiloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways
- vitro+vivo, Kidney, HK-2
α-SMA↓, COL1↓, TGF-β↓, SMAD2↓, SMAD3↓, p‑SMAD2↓, p‑SMAD3↓, p38↓, p‑p38↓, Vim↓, TIMP1↓, CTGF↓, E-cadherin↑, MMP1:TIMP1↑,
3722- Gb,    Alzheimer's disease: Research summaries – Do Ginkgo products help?
- Review, AD, NA
*memory↑, *AntiAg↑,
3723- Gb,    Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies
- Review, AD, NA
*memory↑, *antiOx↑, *Casp3↓, *APP↓, *AChE↓, *Aβ↓, *5HT↑, *SOD↓, *MDA↓, *NO↓, *GSH↑, *Bcl-2↑, *BAX↑, *TNF-α↓, *IL1β↑, *iNOS↓, *IL10↓, *p‑tau↓, *ROS↓, *MAOB↓, *cognitive↑, *neuroP↑, *Apoptosis↓,
3721- Gb,    Ginkgo biloba Extract in Alzheimer’s Disease: From Action Mechanisms to Medical Practice
- Review, AD, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSR↑, *MMP↑, *Inflam↓, *Aβ↓, *memory↑, *Dose↝, *BBB↑, *neuroP↑,
790- GE,    A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)
- vitro+vivo, NA, NA
other↓,
791- GE,    Germanium Sesquioxide Organic Germanium
other↝,
792- GE,    The role of germanium in diseases: exploring its important biological effects
other↓,
789- GE,    Complete remission of pulmonary spindle cell carcinoma after treatment with oral germanium sesquioxide
- Case Report, SCC, NA
Remission↑,
927- GEN,  PacT,    Bioenhancers from mother nature and their applicability in modern medicine
- Review, Nor, NA
*BioAv↑,
28- GEN,    Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway
- in-vivo, BC, MCF-7
HH↓, Smo↓, Gli1↓, TumCG↓, TumCP↓, Apoptosis↑, CSCs↓,
29- GEN,    Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog-Gli1 pathway
- in-vivo, Pca, 22Rv1 - in-vivo, Pca, DU145
HH↓, Gli1↓, CSCs↓, TumCI↓, EMT↓, TumCG↓, CD44↓,
166- GEN,  EGCG,  RES,  CUR,    Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer
- in-vivo, Pca, NA
HH↓, Gli1↓,
1504- GEN,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
DNMTs↓, P21↑, p16↑, ac‑H3↑, ac‑H4↑, TumCCA↑, Casp↑, Apoptosis↑, hTERT/TERT↓, BTG3↑,
1435- GEN,  SFN,    The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
DNMTs↓, HDAC↓, eff↑, TumCCA↑, HMTs↓, HDAC2↓, HDAC3↓, KLF4↓, hTERT/TERT↓,
2998- GEN,    Cellular and Molecular Mechanisms Modulated by Genistein in Cancer
- Review, Var, NA
Hif1a↓, VEGF↓, PDGF↓, uPA↓, MMP2↓, MMP9↓, chemoPv↑, TumCI↓, TumMeta↓, NF-kB↓, AP-1↓, IKKα↓, PI3K↓, Akt↓, EMT↓, CSCs↓,
2997- GEN,    Genistein Inhibition of Topoisomerase IIα Expression Participated by Sp1 and Sp3 in HeLa Cell
- in-vitro, Cerv, HeLa
TOP2↓, Sp1/3/4↓, Apoptosis↑, TumCCA↑,
4664- GEN,  CUR,  RES,  EGCG,  SFN  Targeting cancer stem cells by nutraceuticals for cancer therapy
- Review, Var, NA
CSCs↓, other↝, eff↑, CD44↓, p‑STAT3↓,
30- Ger,    A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, AsPC-1
HH↓, Gli1↓, Shh↓, cycD1/CCND1↓, TumCP↓,
1116- GI,    6-Shogaol Inhibits the Cell Migration of Colon Cancer by Suppressing the EMT Process Through the IKKβ/NF-κB/Snail Pathway
- in-vitro, Colon, Caco-2 - in-vitro, CRC, HCT116
TumCG↓, Apoptosis↑, TumCMig↓, MMP2↓, N-cadherin↓, IKKα↓, p‑NF-kB↓, Snail↓, VEGF↓,
1005- GI,    Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
- vitro+vivo, Nor, HUVECs
*NF-kB↓, *p65↓, *TLR4∅, *angioG↓, *TumCP↓, *VEGF↓, *Inflam↓, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *p‑JNK↓, *HO-1↑,
4246- GI,    Ginger oil-loaded transdermal adhesive patch treats post-traumatic stress disorder
- in-vivo, NA, NA
*BDNF↑, *Inflam↓,
4247- GI,    6-Shogaol from Dried Ginger Protects against Intestinal Ischemia/Reperfusion by Inhibiting Cell Apoptosis via the BDNF/TrkB/PI3K/AKT Pathway
- vitro+vivo, NA, NA
*BDNF↑, *TrkB↑, *PI3K↑, *Akt↑, *Apoptosis↓, *Inflam↓, *antiOx↑,
2464- GI,    The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *LDL↓, *AntiAg↑, *AntiAg∅,
2465- GI,    Effect of daily ginger consumption on platelet aggregation
- Trial, Nor, NA
AntiAg↝, Dose∅,
4242- Gins,    Ginseng Extract G115 Attenuates Ethanol-Induced Depression in Mice by Increasing Brain BDNF Levels
- in-vivo, NA, NA
*BDNF↑, *Mood↑, *neuroP↑,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
4301- Gins,    Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation In Vitro
- in-vitro, AD, NA
*p‑tau↓, *eff↑, *Inflam↓,
4243- Gins,    Effects of Ginseng on Neurological Disorders
- Review, Stroke, NA - Review, AD, NA - Review, Park, NA
*BDNF↑, *TrkB↑, *neuroP↑, *VEGF↑, *p‑tau↓, *memory↑,
4004- Gins,    Effects of fermented ginseng on memory impairment and β-amyloid reduction in Alzheimer’s disease experimental models
- in-vivo, AD, NA
*memory↑, *Aβ↓,
3998- Gins,    Ginseng for Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Trial, AD, NA
*other↝,
4003- Gins,    Neuroprotective Potentials of Panax Ginseng Against Alzheimer's Disease: A Review of Preclinical and Clinical Evidences
- Review, adrenal, NA
*neuroP↑, *Inflam↓, *ROS↓, *BACE↓, *PPARγ↑, *Aβ↓, *p‑tau↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓, *CREB↓, *BDNF↑, *memory↑,
4002- Gins,    Improvement of cognitive deficit in Alzheimer's disease patients by long term treatment with korean red ginseng
- Trial, AD, NA
*cognitive↑, *other↑,
4001- Gins,    An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's disease
- Human, AD, NA
*cognitive↑,
4000- Gins,    Heat-processed ginseng enhances the cognitive function in patients with moderately severe Alzheimer's disease
- Human, AD, NA
*cognitive↑,
3999- Gins,    Panax ginseng enhances cognitive performance in Alzheimer disease
- Trial, NA, NA
*cognitive↑,

Showing Research Papers: 2901 to 2950 of 5859
Prev Page 59 of 118 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5859

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   AMPK↑, 1,   FASN↓, 1,   lipoGen↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 8,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-xL↓, 1,   BTG3↑, 1,   Casp↑, 1,   Casp3↑, 1,   Casp9↑, 1,   cFLIP↓, 2,   DR5↑, 2,   hTERT/TERT↓, 2,   Mcl-1↓, 1,   p38↓, 1,   p‑p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

H3K18↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   other↓, 2,   other↑, 1,   other↝, 2,   tumCV↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNMTs↓, 2,   p16↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 2,   P21↑, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 2,   CSCs↓, 4,   EMT↓, 2,   Gli1↓, 4,   HDAC↓, 1,   HDAC11↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HH↓, 4,   HMTs↓, 1,   KLF4↓, 1,   PI3K↓, 1,   PTEN↑, 1,   PTPN6↑, 1,   Shh↓, 1,   Smo↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   TOP2↓, 1,   TumCG↓, 4,  

Migration ⓘ

AntiAg↝, 1,   AP-1↓, 1,   COL1↓, 1,   CTGF↓, 1,   E-cadherin↑, 1,   HLA↑, 1,   Ki-67↑, 1,   MMP1:TIMP1↑, 1,   MMP2↓, 3,   MMP9↓, 2,   N-cadherin↓, 1,   PDGF↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumCP↓, 5,   TumMeta↓, 1,   TumMeta↑, 1,   uPA↓, 1,   Vim↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 4,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IKKα↓, 2,   Inflam↓, 1,   NF-kB↓, 2,   p‑NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,   eff↑, 2,  

Clinical Biomarkers ⓘ

hTERT/TERT↓, 2,   Ki-67↑, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,   Remission↑, 1,   TumVol↓, 1,  
Total Targets: 100

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 4,   Catalase↑, 1,   GSH↑, 1,   GSR↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 2,   ROS↓, 5,   SOD↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↓, 1,   CREB↑, 1,   LDL↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↑, 2,   Apoptosis↓, 2,   BAX↑, 1,   Bcl-2↑, 1,   Casp3↓, 1,   iNOS↓, 1,   p‑JNK↓, 1,   MAPK↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 2,   other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   PI3K↑, 2,  

Migration ⓘ

AntiAg↑, 2,   AntiAg∅, 1,   APP↓, 2,   E-sel↓, 1,   PKA↑, 1,   TumCP↓, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   NO↓, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

ICAM-1↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL1β↑, 1,   IL6↓, 1,   Inflam↓, 7,   NF-kB↓, 2,   p65↓, 1,   TLR4∅, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 1,   ADAM10↑, 1,   BDNF↑, 6,   BDNF∅, 1,   p‑tau↓, 5,   TrkB↑, 2,  

Protein Aggregation ⓘ

Aβ↓, 5,   BACE↓, 2,   IDE↑, 1,   MAOB↓, 1,   PP2A↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Dose↝, 1,   Dose∅, 1,   eff↑, 2,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 6,   memory↑, 8,   Mood↑, 1,   neuroP↑, 6,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 73

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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