toxicity Cancer Research Results

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Type:
Toxicity
Scientific Papers found: Click to Expand⟱
1446- Deg,    Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells
- in-vitro, BC, 4T1
cMET↓, p‑ERK↓, p‑Akt↓, TumCMig↓, TumCG↓, Weight∅, *toxicity∅, Hif1a↓, TumMeta↓,
6676- Deg,    Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry
- Review, Var, NA
TumCP↓, Apoptosis↑, NF-kB↓, Wnt↓, TumCCA↑, TumMeta↑, antiOx↑, Inflam↓, angioG↓, Half-Life↑, MMP2↓, MMP9↓, Casp9↑, Casp3↑, EMT↓, PTEN↑, ChemoSen↑, toxicity↑, *BBB↑,
6671- Deg,    A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy
- in-vitro, Nor, BEAS-2B - in-vitro, Lung, H1299 - in-vitro, Lung, H460
HSP90↓, toxicity↝, eff↑, chemoPv↑, p53 Wildtype↓, CDK4↓, MAPK↓, Hif1a↓, selectivity↑, compI↓, TumCP↓, BioAv↑,
6705- DFC,    Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases
- Review, Var, NA
*Inflam↓, *Pain↓, *COX1↓, *COX2/PTGS2↓, *toxicity↝, *BioAv↑, *AntiAg↑, *neuroP↑, ROS↑, p73↑, Myc↓, lactateProd↓, TumCCA↑, PI3K↓, Akt↓, NF-kB↓, SOD2↓, *neuroP↑,
6688- DFC,    New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells
- in-vivo, lymphoma, U937
AntiCan↑, COX2/PTGS2↓, Myc↓, GLUT1↓, LDHA↓, MCT1↓, GlucoseCon↓, lactateProd↓, TumCP↓, other∅, toxicity↝,
6694- DFC,    Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, angioG↓, ChemoSen↑, RadioS↑, Dose↝, toxicity↝, toxicity↝, BioAv↑, Half-Life↝, lactateProd↓, eff↑, *AntiAg↑,
6745- DHA,    Omega-3 fatty acid DHA induces ferroptosis in colorectal cancer patient-derived organoids and drug-tolerant cells
- in-vitro, CRC, HT29
tumCV↓, selectivity↑, Ferroptosis↑, lipid-P↑, mt-ROS↑, ChemoSen↑, *toxicity↓, TumCG↓, eff↑, eff↑, Dose↝, mtDam↑, *Inflam↓, *chemoP↑, Dose↑,
6758- DHA,  Chemo,    Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial
- Trial, BC, NA
ChemoSen↑, selectivity↑, ROS↑, *toxicity↓, Dose↝,
951- DHA,    Docosahexaenoic Acid Attenuates Breast Cancer Cell Metabolism and the Warburg Phenotype by Targeting Bioenergetic Function
- in-vitro, BC, BT474 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Hif1a↓, GLUT1↓, LDH↓, GlucoseCon↓, lactateProd↓, ATP↓, p‑AMPK↑, ECAR↓, OCR↓, *toxicity↓,
6710- dietF,    The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on fermented foods
- Review, Nor, NA
*other↝, *toxicity↓, *toxicity↓, *Obesity↓, *AntiDiabetic↑, *cardioP↑, *GutMicro↑, *Imm↑,
1849- dietFMD,    The emerging role of fasting-mimicking diets in cancer treatment
- Review, Var, NA
TumCG↓, toxicity∅, BG↓, IGF-1↓, mTOR↓, M2 MC↓, eff↑, ChemoSen↑, QoL↑, RadioS↑, selectivity↑,
1852- dietFMD,  Chemo,    Starvation Based Differential Chemotherapy: 
A Novel Approach for Cancer Treatment
- Review, Var, NA
ChemoSideEff↓, *toxicity↓, mTOR↓, IGF-1↓, IGFBP1↑, BG↓, ROS↑,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
1810- dietKeto,  Oxy,    The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer
- in-vivo, Var, NA
BG↓, TumCG↓, OS↑, eff↑, Dose∅, KeyT↑, eff↑, cachexia↓, ChemoSen↑, *ROS↓, ROS↑, lipid-P↑, selectivity↑, toxicity∅,
5193- dietMet,  Rad,    A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy
- Trial, Var, NA
toxicity↝, other↝,
6278- DL,    Safety evaluation and risk assessment of d-Limonene
- Review, Nor, NA
*toxicity↓,
6265- DL,    Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee
- Trial, Var, NA
toxicity↓, Dose↑, OS↑,
6267- DL,    Effect of d-limonene and its derivatives on breast cancer in human trials: a scoping review and narrative synthesis
- Review, BC, NA
*toxicity↓, cycD1/CCND1↓, TumCP↓, other↑,
6277- DL,  docx,    d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
- in-vitro, Pca, DU145 - in-vitro, Nor, PZ-HPV-7
ChemoSen↑, selectivity↑, ROS↑, GSH↓, Casp↑, eff↓, TumCP↓, cl‑Casp9↑, cl‑Casp3↑, P21↑, BAD↑, cl‑PARP↑, Bcl-xL↓, P53↑, mtDam↑, *toxicity↓,
6288- DL,    From Citrus to Clinic: Limonene’s Journey Through Preclinical Research, Clinical Trials, and Formulation Innovations
- Review, Var, NA - Review, AD, NA
other↑, DDS↑, *antiOx↑, *Inflam↓, *AntiDiabetic↑, *neuroP↑, *Imm↑, *Wound Healing↑, *other↑, *BioAv↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *DNAdam↓, *AntiDiabetic↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, *AChE↓, *BChE↓, *Aβ↓, *ROS↓, *toxicity?,
6281- DL,    Applications of Limonene in Neoplasms and Non-Neoplastic Diseases
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
*antiOx↑, AntiTum↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *ROS↓, *toxicity↓, *BioAv↑, ChemoSen↑, BAX↑, P53↓, Bcl-2↓, iNOS↓, COX2/PTGS2↓, eff↑, ROS↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, TumCMig↓, *lipid-P↓, *GSH↑, *SOD↑, *GPx↑, *hepatoP↑, *glucose↓, *AGEs↓, *Obesity↓, *Aβ↓, *AChE↓,
6348- DRE,    New prospects in oncotherapy: bioactive compounds from Taraxacum officinale
- Review, Var, NA
Dose↝, TumCP↓, toxicity↓, *AntiDiabetic↑, *antiOx↑, *hepatoP↑, *diuretic↑, *Inflam↓, *neuroP↑, *Imm↑, eff↑, Apoptosis↑, tumCV↓, selectivity↑, TumCMig↓, EMT↓, MMP2↓, MMP9↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, JNK↓, ERK↓,
6317- DRE,    The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells
- in-vitro, Melanoma, A375
Apoptosis↑, selectivity↑, Casp8↑, mt-ROS↑, eff↑, *toxicity↓, Diff↑, TumCP↓, chemoPv↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *RNS↓, TumCI↓, MMP2↓, MMP9↓, p‑Src↓, p‑FAK↓,
6318- DRE,    Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways
- vitro+vivo, CRC, HCT116 - NA, Nor, NCM460
TumCD↑, Apoptosis↑, Casp8↑, selectivity↑, TumCMig↓, selectivity↑, Dose↝, toxicity↓, TumCG↓, MMP↓, mt-ROS↑, *ROS↓, BID↑, Bcl-2↓, PARP↓, NF-kB↑, *NF-kB↓, Casp1↑, *Casp1↓, COX2/PTGS2↑, OXPHOS↓, ETC↓,
6319- DRE,    Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells
- in-vitro, AML, MV411 - in-vitro, AML, HL-60
Apoptosis↑, TumAuto↑, *toxicity↓, selectivity↑, Casp8↑, MMP↓, *Inflam↓, *antiOx↑, *AntiCan↑, DNAdam↑, cl‑Casp3↑, tumCV↓, ROS↑,
6322- DRE,  LGE,    Dandelion Root and Lemongrass Extracts Induce Apoptosis, Enhance Chemotherapeutic Efficacy, and Reduce Tumour Xenograft Growth In Vivo in Prostate Cancer
- vitro+vivo, Pca, DU145
AntiCan↑, ChemoSen↑, Dose↝, *ROS↓, Apoptosis↑, selectivity↑, *toxicity↓, *chemoP↑, eff↓, ROS↑,
6357- DRE,    New Perspectives on the Effect of Dandelion, Its Food Products and Other Preparations on the Cardiovascular System and Its Diseases
- Review, Nor, NA
*cardioP↑, *Dose↝, *Dose↝, *toxicity∅, *toxicity↓, *BP↓, *Inflam↓, *Bacteria↓, *Imm↑, *lipid-P↓, *AST↓, *ALAT↓, *AntiAg↑, *ROS↓, *AntiThr↑,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
4913- DSF,    Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
- Review, Var, NA
Apoptosis↑, tumCV↑, eff↑, toxicity↓, antiNeop↑, ChemoSen↑, RadioS↑, OS↑, ROS↑, SOD↓, MMP1↓, eff↑, Half-Life↓,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp/ABCB1↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
4917- DSF,  Chemo,  Cu,    Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients With Recurrent Glioblastoma
- Trial, GBM, NA
OS∅, toxicity↑,
5013- DSF,  Cu,  Z,    Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
- vitro+vivo, Melanoma, NA - Case Report, Melanoma, NA
P-gp/ABCB1↓, NF-kB↓, ChemoSen↑, angioG↓, TumCG↓, TumMeta↓, Remission↑, toxicity↓, ATF2↓, CREB↓, cycA1/CCNA1↓, TumCG↓, angioG↓, Dose↝, toxicity↝,
6803- EA,    Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial
- Trial, IBD, NA
*Dose↝, *MDA↓, *TAC↑, *CRP↓, *IL6↓, *Inflam↓, *ROS↓, *QoL↑, *toxicity↓,
6802- EA,    Support ellagic acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard chemotherapy using vinorelbine and estramustine phosphate
- Human, Pca, NA
*toxicity↓, chemoP↑, Neut↑, PSA↓, Dose↝,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, eff↑, COX2/PTGS2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2/KDR/Flk1↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
6634- Ech,    Echinacea purpurea: Pharmacology, phytochemistry and analysis methods
- Review, Var, NA
AntiArt↑, *Imm↑, *Neut↑, *NK cell↑, *COX1↓, *COX2/PTGS2↓, *Inflam↓, TumCG↑, *toxicity↓,
6617- Ech,    Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
Dose↝, selectivity↑, TumCCA↑, Apoptosis↑, toxicity↓, ChemoSen↑, other↝, *antiOx↑,
7209- EGb 761,    Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review
- Review, AD, NA
*cognitive↑, *toxicity↓,
7202- EGb 761,    Ginkgo biloba leaf extract EGb 761® for the treatment of various diseases: Overview of systematic reviews
- Review, AD, NA
*cognitive↑, *Tinn↓, *toxicity↓,
7200- EGb 761,  PCA,    Optimized Ginkgo biloba extract EGb 761®: boosted therapeutic benefits with minimized CYP enzyme interference
*Dose↝, *AChE↓, *GSK‐3β↝, *eff↑, *cognitive↑, *toxicity↓,
7196- EGb 761,    Ginkgo biloba extract EGb 761 in patients with dementia and a history of cerebral infarction-meta-analysis of pooled data from randomised clinical trials
- Review, AD, NA - Review, Stroke, NA
*neuroP↑, *cognitive↑, *Stroke↓, *toxicity↓, Dose↝,
7232- EGb 761,    Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial
- Trial, AD, NA
*cognitive↑, *toxicity↓,
7231- EGb 761,    Efficacy and tolerability of Ginkgo biloba extract EGb 761® in dementia: a systematic review and meta-analysis of randomized placebo-controlled trials
- Review, AD, NA
*toxicity↓, *eff↑, *cognitive↑, *other↑, *eff↑,
7229- EGb 761,    Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia
- Review, AD, NA
*toxicity↓, *Dose↝, *ROS↓, *PAF↓, *memory↑, *BloodF↑, *antiOx↑, *Inflam↓, *Tinn↓,
7222- EGb 761,    Ginkgo biloba extract EGb 761® in the symptomatic treatment of mild-to-moderate dementia: a profile of its use
- Review, AD, NA
*cognitive↑, *toxicity↓, *Dose↝, *BioAv↑, *Half-Life↑, *neuroP↑, *Half-Life↝, *Dose↝, *other↝, *eff↑,
3208- EGCG,    Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α
- in-vitro, Colon, HT29 - in-vitro, Nor, 3T3
TumCD↓, ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑, Casp3↑, Casp7↑, Wnt↓, β-catenin/ZEB1↓, *toxicity∅, UPR↑,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *eff↑, *BioAv↑, eff↑, ChemoSen↑, *toxicity↝,
6785- EGCG,    Epigallocatechin-3-gallate at the nanoscale: a new strategy for cancer treatment
- Review, Var, NA
AntiCan↑, BioAv↓, BioAv↑, EPR↑, TumCG↓, *Half-Life↝, BioAv↑, eff↑, eff↑, eff↑, NF-kB↓, ROS↑, ChemoSen↑, *toxicity↝,

Showing Research Papers: 251 to 300 of 698
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 698

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   compI↓, 1,   Ferroptosis↑, 1,   GSH↓, 1,   lipid-P↑, 2,   NRF2↓, 1,   OXPHOS↓, 1,   ROS↑, 14,   mt-ROS↑, 3,   SOD↓, 2,   SOD2↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ETC↓, 1,   Insulin↓, 1,   MMP↓, 2,   mtDam↑, 3,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   p‑AMPK↑, 1,   cMyc↓, 1,   CREB↓, 1,   ECAR↓, 1,   GlucoseCon↓, 2,   KeyT↑, 1,   lactateProd↓, 4,   LDH↓, 1,   LDHA↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   p‑Akt↓, 1,   Apoptosis↑, 12,   mt-Apoptosis↑, 1,   ATF2↓, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 4,   Bcl-2↓, 5,   Bcl-xL↓, 2,   BID↑, 1,   Casp↑, 1,   Casp1↑, 1,   Casp3↑, 4,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 5,   Casp9↑, 3,   cl‑Casp9↑, 1,   Ferroptosis↑, 1,   iNOS↓, 1,   JNK↓, 1,   MAPK↓, 3,   MCT1↓, 1,   Myc↓, 2,   TumCD↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

miR-25-5p↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 2,   other∅, 1,   tumCV↓, 4,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSP90↓, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 4,   P53↓, 1,   P53↑, 2,   p53 Wildtype↓, 1,   p73↑, 1,   PARP↓, 1,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE1↓, 1,   P21↑, 2,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CDK8↓, 1,   cMET↓, 1,   CSCs↓, 2,   Diff↑, 1,   EMT↓, 5,   ERK↓, 1,   p‑ERK↓, 1,   IGF-1↓, 2,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↓, 3,   NOTCH↓, 1,   P90RSK↓, 1,   PI3K↓, 5,   PTEN↑, 1,   Shh↓, 1,   p‑Src↓, 1,   STAT3↓, 3,   TumCG↓, 10,   TumCG↑, 1,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

FAK↓, 1,   p‑FAK↓, 1,   MMP1↓, 1,   MMP2↓, 4,   MMP9↓, 3,   NEDD9↓, 1,   Smad1↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 3,   TumCI↓, 3,   TumCMig↓, 6,   TumCP↓, 9,   TumMeta↓, 4,   TumMeta↑, 1,   Twist↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   ATF4↑, 1,   EGFR↓, 1,   EPR↑, 1,   Hif1a↓, 4,   VEGF↓, 3,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 5,   COX2/PTGS2↑, 1,   IL6↓, 1,   Imm↑, 3,   Inflam↓, 1,   M2 MC↓, 1,   Neut↑, 1,   NF-kB↓, 7,   NF-kB↑, 1,   PGE2↓, 1,   PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 5,   BioAv↝, 1,   ChemoSen↑, 18,   DDS↑, 1,   Dose↑, 3,   Dose↝, 12,   Dose∅, 1,   eff↓, 2,   eff↑, 25,   eff↝, 2,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 1,   RadioS↑, 7,   selectivity↑, 15,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BG↓, 4,   EGFR↓, 1,   IL6↓, 1,   LDH↓, 1,   Myc↓, 2,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   antiNeop↑, 1,   AntiTum↑, 2,   cachexia↓, 1,   chemoP↑, 1,   chemoPv↑, 2,   ChemoSideEff↓, 2,   OS↑, 3,   OS∅, 1,   QoL↑, 1,   QoL∅, 1,   Remission↑, 1,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 8,   toxicity∅, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 192

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   diuretic↑, 1,   PAF↓, 1,   Stroke↓, 1,   Tinn↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 3,   lipid-P↓, 2,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 1,   OXPHOS↑, 1,   RNS↓, 1,   ROS↓, 11,   SOD↑, 3,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   glucose↓, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Casp1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↑, 2,   other↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↝, 1,   mTOR↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 3,   CRP↓, 1,   IL6↓, 2,   Imm↑, 5,   Inflam↓, 12,   Neut↑, 1,   NF-kB↓, 1,   NK cell↑, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BChE↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 3,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 6,   Dose↝, 7,   eff↑, 5,   Half-Life↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BloodF↑, 1,   BP↓, 1,   CRP↓, 1,   GutMicro↑, 3,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 5,   cardioP↑, 4,   chemoP↑, 2,   cognitive↑, 7,   hepatoP↑, 4,   memory↑, 1,   neuroP↑, 9,   Obesity↓, 3,   Pain↓, 1,   QoL↑, 1,   toxicity?, 1,   toxicity↓, 26,   toxicity↝, 3,   toxicity∅, 8,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 2,  
Total Targets: 79

Scientific Paper Hit Count for: toxicity, toxicity
31 Silver-NanoParticles
21 Selenium NanoParticles
17 chitosan
16 Magnetic Fields
13 Chemotherapy
13 Dichloroacetate
12 Selenite (Sodium)
12 Sulforaphane (mainly Broccoli)
11 5-Hydroxytryptophan
11 Radiotherapy/Radiation
10 3-bromopyruvate
10 Curcumin
10 EGCG (Epigallocatechin Gallate)
10 Hydrogen Gas
9 Honokiol
9 Phenylbutyrate
8 Cisplatin
8 Copper and Cu NanoParticles
8 Ginkgo biloba-EGb 761
8 Fenbendazole
8 itraconazole
7 Ashwagandha(Withaferin A)
7 Baicalein
7 Berberine
7 Carvacrol
7 Dandelion Root
7 Graviola
6 Apigenin (mainly Parsley)
6 borneol
6 Boron
6 Metformin
6 D-limonene
6 Emodin
6 Eugenol
6 Germanium inorganic
6 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
6 Resveratrol
6 Magnetic Field Rotating
6 Piperlongumine
6 Pterostilbene
6 Selenium
5 Auranofin
5 Allicin (mainly Garlic)
5 HydroxyCitric Acid
5 Artemisinin
5 Capsaicin
5 Ellagic acid
5 Hyperthermia
5 Inositol
5 Lactoferrin/Talactoferrin
5 Shikonin
5 Urolithin
5 Vitamin K2
4 Gold NanoParticles
4 Alpha-Lipoic-Acid
4 beta-glucans
4 Betulinic acid
4 α-Bisabolol / Chamomile oil
4 Celastrol
4 Chlorogenic acid
4 chaetocin
4 Chrysin
4 Cucurbitacin
4 salinomycin
4 Deguelin
4 Disulfiram
4 Folic Acid, Vit B9
4 Fucoidan
4 Gambogic Acid
4 Garcinol
4 Ginkgolic acids
4 Ginkgo biloba
4 Germanium Organic/Ge-132 / propagermanium (organogermanium)
4 Ginger/6-Shogaol/Gingerol
4 isoorientin
4 Kaempferol
4 Propolis -bee glue
4 Phenethyl isothiocyanate
4 Silymarin (Milk Thistle) silibinin
4 Thymoquinone
3 Vitamin C (Ascorbic Acid)
3 SonoDynamic Therapy UltraSound
3 Anti-oxidants
3 doxorubicin
3 Atorvastatin
3 Baicalin
3 Beta-Caryophyllene
3 Bullatacin
3 Carnosine
3 Centella asiatica / Gotu kola → asiaticoside
3 Chlorophyllin
3 Cinnamon
3 Diclofenac
3 Docosahexaenoic Acid
3 diet FMD Fasting Mimicking Diet
3 Oxygen, Hyperbaric
3 Ivermectin
3 Gallic acid
3 Geldanamycin
3 Genistein (soy isoflavone)
3 Ginkgetin
3 Gossypol/AT-101
3 HydroxyTyrosol
3 Indole-3-carbinol
3 Isoliquiritigenin
3 Licochalcone A
3 Magnolol
3 Melatonin
3 Bicarbonate(Sodium)
3 Niclosamide (Niclocide)
3 Quercetin
3 Rosmarinic acid
3 Sulfasalazine
2 Astragalus
2 Zinc
2 Ascorbyl Palmitate
2 Paclitaxel/Taxol
2 Arsenic trioxide
2 Aloe anthraquinones
2 Berbamine
2 brusatol
2 Bacopa monnieri
2 Boswellia (frankincense)
2 Thymol-Thymus vulgaris
2 carboplatin
2 Hydroxycinnamic-acid
2 Coenzyme Q10
2 Vitamin E
2 CUSP9
2 Docetaxel
2 Lemongrass Extract/Citral
2 immunotherapy
2 Echinacea
2 Estragole
2 Fennel Oil/Foeniculum vulgare
2 Evodiamine
2 Ferulic acid
2 Flickering Light Stimulation
2 Formononetin
2 Shilajit/Fulvic Acid
2 Gamma-aminobutyric acid
2 Germanium-Spirogermanium
2 Germacranolide sesquiterpene lactone
2 Hibiscus sabdariffa
2 Hyperoside
2 isoflavones
2 isoquercitrin
2 Laetrile B17 Amygdalin
2 Lapatinib
2 Luteolin
2 Lycopene
2 metronomic chemo
2 Propyl gallate
2 Piperine
2 Psoralidin
2 Ramucirumab (CYRAMZA)
2 EMF
2 Terpinen-4-ol / Tea Tree Oil
2 tetrathiomolybdate
2 Whole Body Vibration
1 1,8-Cineole
1 Resiquimod
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 5-Aminolevulinic acid
1 Aspirin
1 Astaxanthin
1 Dipyridamole
1 Biochanin A
1 Bufalin/Huachansu
1 Brucea javanica
1 Bromelain
1 Bruteridin(bergamot juice)
1 Butyrate
1 Carnosic acid
1 Catechins
1 Cat’s Claw
1 Celecoxib
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Citric Acid
1 Carica papaya leaf extract
1 Camptothecin
1 irinotecan
1 Crocetin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Black phosphorus
1 chemodynamic therapy
1 Cynaropicrin
1 Cysteamine
1 diet Fermented Foods
1 diet Ketogenic
1 diet Methionine-Restricted Diet
1 Protocatechuic acid
1 ferumoxytol
1 Fisetin
1 Auditory Gamma Stimulation / 40 Hz Auditory Stimulation
1 Vitamin D3
1 Ginkgolide B
1 Grapeseed extract
1 hydroxychloroquine
1 Isobavachalcone
1 imatinib
1 Inulin Prebiotic
1 Isovitexin
1 Juglone
1 L-ornithine
1 Trastuzumab
1 Lapachol
1 Lasiodin
1 Linalool
1 MCToil
1 Methyl Jasmonate
1 Methyl salicylate / Sweet Birch oil
1 magnetic nanoparticles
1 Moringa oleifera
1 Mushroom Lion’s Mane
1 nicotinamide adenine dinucleotide
1 Naringin
1 Oleuropein
1 Peppermint
1 5-fluorouracil
1 sericin
1 Sanguinarine
1 Plumbagin
1 probiotics
1 Bifidobacterium
1 benzo(a)pyrene
1 Rauwolfia serpentina/Indian Snakeroot
1 Rutin
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Date Fruit Extract
1 Taurine
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin B1/Thiamine
1 Vitexin
1 Wogonin
1 Xylitol
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1025  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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