RadioS Cancer Research Results

RadioS, RadioSensitizer: Click to Expand ⟱
Source:
Type:
A radiosensitizer is an agent that makes cancer cells more sensitive to the damaging effects of radiation therapy. By using a radiosensitizer, clinicians aim to enhance the effectiveness of radiation treatment by either increasing the damage incurred by tumor cells or by interfering with the cancer cells’ repair mechanisms. This can potentially allow for lower doses of radiation, reduced side effects, or improved treatment outcomes.
Pathways that help Radiosensitivity: downregulating HIF-1α, increase SIRT1, Txr

List of Natural Products with radiosensitizing properties:
-Curcumin:modulate NF-κB, STAT3 and has been shown in preclinical studies to enhance the effects of radiation by inhibiting cell survival pathways.
-Resveratrol:
-EGCG:
-Quercetin:
-Genistein:
-Parthenolide:

How radiosensitizers inhibit the thioredoxin (Trx) system in cellular contexts. Notable radiosensitizers, including:
-gold nanoparticles (GNPs),
-gold triethylphosphine cyanide ([Au(SCN) (PEt3)]),
-auranofin, ceria nanoparticles (CONPs),
-curcumin and its derivatives,
-piperlongamide,
-indolequinone derivatives,
-micheliolide,
-motexafin gadolinium, and
-ethane selenide selenidazole derivatives (SeDs)
Scientific Papers found: Click to Expand⟱
2043- PB,  Cisplatin,    Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin
- in-vitro, HNSCC, UM-SCC-1
ChemoSen↑, eff↑, HDAC↓, BRCA1↓, RadioS↑,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, Synergy↑, Synergy↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1673- PBG,    An Insight into Anticancer Effect of Propolis and Its Constituents: A Review of Molecular Mechanisms
- Review, Var, NA
TumCP↓, Apoptosis↑, TumCCA↑, MALAT1↓, P53↑, RadioS↑, OS↑, ROS↑, NF-kB↓, p65↑, MMP↓, ROS↑, MMP9↓, β-catenin/ZEB1↓, Vim↓, E-cadherin↓, VEGF↓, EMT↓,
1683- PBG,  Rad,    Protective effect of propolis in protecting against radiation-induced oxidative stress in the liver as a distant organ
- in-vivo, Nor, NA
GPx↑, SOD↓, RadioS↑,
1661- PBG,    Propolis: a natural compound with potential as an adjuvant in cancer therapy - a review of signaling pathways
- Review, Var, NA
JNK↓, ERK↓, Akt↓, NF-kB↓, FAK↓, MAPK↓, PI3K↓, Akt↓, P21↑, p27/CDKN1B↑, TRAIL↑, BAX↑, P53↑, ERK↓, ChemoSen↑, RadioS↑, Glycolysis↓, HK2↓, PKM2↓, LDHA↓, PFK↓,
1662- PBG,    The immunomodulatory and anticancer properties of propolis
- Review, Var, NA
IL6↓, IL12↓, IL10↑, CSCs↓, PAK1↓, VEGF↓, MMP2↓, MMP9↓, NF-kB↓, Hif1a↓, ChemoSen↑, RadioS↑,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2/PTGS2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27/CDKN1B↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
5208- PI,    Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
- in-vitro, GC, SNU16 - in-vitro, Nor, GES-1
TumCP↓, Apoptosis↑, BAX↑, BAD↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, Bcl-2↓, Bcl-xL↓, p‑PI3K↓, p‑Akt↓, Ki-67↓, toxicity↓, RadioS↑,
2942- PL,    Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems
- in-vitro, CRC, CT26 - in-vitro, CRC, DLD1 - in-vivo, CRC, CT26
ROS↑, GSH↓, TrxR↓, RadioS↑, DNAdam↑, TumCCA↑, mitResp↓, GSTs↓, OS↑,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31/PECAM-1↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,
1985- PTL,    KEAP1 Is a Redox Sensitive Target That Arbitrates the Opposing Radiosensitive Effects of Parthenolide in Normal and Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Nor, PrEC - in-vivo, NA, NA
ROS↑, NADPH↑, RadioS↑, radioP↑, Trx↓, *ox-Keap1↑, ox-Keap1↓, rd-Keap1↑, *NRF2↑, NRF2∅, NF-kB↓,
1987- PTL,  Rad,    A NADPH oxidase dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Nor, PrEC
selectivity↑, RadioS↑, ROS↑, *ROS∅, NADPH↑, Trx↓, PI3K↑, Akt↑, p‑FOXO3↓, SOD2↓, Catalase↓, radioP↑, *NADPH∅, *GSH↑, *GSH/GSSG↑, *NRF2↑,
1983- PTL,    Targeting thioredoxin reductase by micheliolide contributes to radiosensitizing and inducing apoptosis of HeLa cells
- in-vitro, Cerv, HeLa
CompStab↑, TrxR↓, ROS↑, RadioS↑,
1493- QC,  Rad,    New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer
- in-vivo, Bladder, NA
RadioS↑, ChemoSen↑,
97- QC,  HPT,    Effects of the flavonoid drug Quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo
- in-vitro, Pca, PC3
HSP72↑, TumCG↓, Synergy↑, ChemoSen↑, RadioS↑,
7576- Rad,  HPT,    Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group
- Trial, Nor, NA
RadioS↑,
5857- RES,  CAP,  Rad,    Resveratrol and capsaicin as safer radiosensitizers for colorectal cancer compared to 5-fluorouracil
- in-vivo, Var, NA
RadioS↑, hepatoP↝, toxicity↓,
4667- RES,  CUR,  SFN,    Physiological modulation of cancer stem cells by natural compounds: Insights from preclinical models
- Review, Var, NA
CSCs↓, ChemoSen↑, RadioS↑, ALDH↓, CD44↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, HH↓, NF-kB↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2/PTGS2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, Synergy↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
1492- RES,    Resveratrol: Biological and pharmaceutical properties as anticancer molecule
- Review, Var, NA
RadioS↑, ChemoSen↑,
1491- RES,  doxoR,  Cisplatin,    Resveratrol Augments Doxorubicin and Cisplatin Chemotherapy: A Novel Therapeutic Strategy
- in-vivo, Var, NA
RadioS↑, ChemoSen↑,
1489- RES,    Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer
- Review, Var, NA
RadioS↑, ChemoSen↑, *BioAv↓, *BioAv↑, Ferroptosis↑, lipid-P↑, xCT/SLC7A11↓, GPx4↓, *BioAv↑, COX2/PTGS2↓, cycD1/CCND1↓, FasL↓, FOXP3↓, HLA↑, p‑NF-kB↓, BAX↑, Bcl-2↓, MALAT1↓,
1747- RosA,    Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
- Review, BC, MDA-MB-231 - Review, BC, MDA-MB-468
TumCCA↑, TNF-α↑, GADD45A↑, BNIP3↑, survivin↓, Bcl-2↓, BAX↑, HH↓, Synergy↑, ChemoSen↑, RadioS↑, TumCP↓, TumCMig↓, Apoptosis↑, RenoP↑, CardioT↓,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp/ABCB1↓, Synergy↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
4898- Sal,    Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
- Review, Var, NA
CSCs↓, AntiCan↑, ChemoSen↑, RadioS↑, Wnt↓, MAPK↓, TumAuto↑, ATP↓, ROS↑, DNAdam↑, ER Stress↑, CSCsMark↓, Iron↑, *toxicity↝,
4902- Sal,  OXA,    Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, NA
RadioS↑, ChemoSen↑, TumCP↓, Apoptosis↑, ROS↑, MMP↓, MAPK↑, eff↓, TumCG↓, TumCCA↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp/ABCB1↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
4994- Sal,  Rad,    Salinomycin overcomes radioresistance in nasopharyngeal carcinoma cells by inhibiting Nrf2 level and promoting ROS generation
- in-vitro, NPC, NA
AntiCan↑, RadioS↓, Apoptosis↑, NRF2↓, ROS↑, DNAdam↑,
4910- Sal,    A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent
- Review, Var, NA
Apoptosis↑, CSCs↓, ChemoSen↑, RadioS↑, selectivity↑, Wnt↓, toxicity⇅,
5042- SAS,    xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling
- Review, Var, NA
xCT/SLC7A11↓, GSH↓, TumCG↓, TumCI↓, ROS↑, RadioS↑, eff↓,
5138- SAS,  Rad,    Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion
- vitro+vivo, GBM, NA
cystine↓, GSH↓, ROS↑, RadioS↑, eff↓, DNAdam↑, OS↑,
5038- SAS,  Rad,    Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma
- in-vivo, Melanoma, B16-F10
xCT/SLC7A11↓, ROS↑, RadioS↓, GSH↓, selectivity↑, DNArepair↓, TumCCA↑, H2O2↑, Dose↝,
6220- Se,  CUR,  Rad,    Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy
- in-vitro, Lung, A549
RadioS↑, TumCD↑, ROS↑, Imm↑, angioG↓, BioAv↑, TumCP↓, Apoptosis↓, TumMeta↓, CompStab↑,
4615- Se,  Rad,    Selenium as an adjuvant for modification of radiation response
- Review, Nor, NA
*antiOx↑, *radioP↑, *GSH↑, *GPx↑, *Dose↝, selectivity↑, RadioS↑,
4756- SeNPs,    Selenium‐Containing Nanoparticles Combine the NK Cells Mediated Immunotherapy with Radiotherapy and Chemotherapy
- in-vitro, Var, NA
ChemoSen↑, RadioS↓,
4611- SeNPs,  Rad,    Radioprotective Effect of Selenium Nanoparticles: A Mini Review
- Review, Var, NA
*antiOx↑, *Inflam↓, *radioP↑, *ROCK1↓, *DNAdam↓, *Apoptosis↓, *RadioS↑, *Dose↝,
4472- SeNPs,    Therapeutic potential of selenium nanoparticles
- Review, Var, NA
*ROS↓, *BioAv↑, *antiOx↑, toxicity↓, eff↑, *other↝, EPR↑, selectivity↑, eff↑, RadioS↑, eff↑, *Bacteria↓,
4469- SeNPs,    Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
- Review, Var, NA
antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,
3183- SFN,    Sulforaphane potentiates the efficacy of chemoradiotherapy in glioblastoma by selectively targeting thioredoxin reductase 1
- in-vitro, GBM, NA
RadioS↑, TrxR1↓, ROS↑, ChemoSen↑, Prx↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1484- SFN,    Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
- Review, Var, NA - Review, AD, NA
neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,
3306- SIL,  Rad,    Radioprotective and radiosensitizing properties of silymarin/silibinin in response to ionizing radiation
- Review, Var, NA
radioP↑, RadioS↑, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, DNAdam↓, ROS↑, *ROS↓, *Inflam↓,
3297- SIL,  Rad,    Studies on radiation sensitization efficacy by silymarin in colon carcinoma cells
- in-vitro, CRC, HCT15 - in-vitro, CRC, RKO
TumCP↓, RadioS↑, TumCCA↑, DNAdam↓, MMP↓, ROS↓, *radioP↑,
2197- SK,    Shikonin derivatives for cancer prevention and therapy
- Review, Var, NA
ROS↑, Ca+2↑, BAX↑, Bcl-2↓, MMP9↓, NF-kB↓, PKM2↓, Hif1a↓, NRF2↓, P53↑, DNMT1↓, MDR1↓, COX2/PTGS2↓, VEGF↓, EMT↓, MMP7↓, MMP13↓, uPA↓, RIP1↑, RIP3↑, Casp3↑, Casp7↑, Casp9↑, P21↓, DFF45↓, TRAIL↑, PTEN↑, mTOR↓, AR↓, FAK↓, Src↓, Myc↓, RadioS↑,
1706- SSE,    Selenium in Prostate Cancer: Prevention, Progression, and Treatment
- Review, Pca, NA
Risk∅, ChemoSen↑, Risk↓, toxicity↝, Risk↑, Synergy↑, *toxicity↑, RadioS↑, eff↓, eff↑, ChemoSen↑, ChemoSideEff↓,

Showing Research Papers: 251 to 300 of 314
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 314

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 10,   Catalase↓, 6,   Catalase↑, 1,   Catalase∅, 1,   cystine↓, 1,   Fenton↑, 4,   GPx↓, 2,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 4,   GSH↓, 25,   GSH↑, 2,   GSH/GSSG↓, 1,   GSR↓, 1,   GSTs↓, 2,   GSTs↝, 1,   GSTs∅, 1,   H2O2↓, 2,   H2O2↑, 4,   HO-1↓, 9,   HO-1↑, 4,   HO-2↓, 1,   Iron↓, 1,   Iron↑, 2,   i-Iron↑, 1,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↓, 3,   lipid-P↑, 9,   MDA↓, 1,   MDA↑, 2,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 14,   NRF2↑, 11,   NRF2∅, 1,   Prx↓, 1,   Prx4↑, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 12,   ROS↑, 163,   ROS⇅, 5,   ROS↝, 1,   mt-ROS↑, 3,   RPM↑, 1,   SOD↓, 7,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 5,   SOD2↑, 1,   TBARS↑, 1,   Thiols↓, 1,   Trx↓, 3,   TrxR↓, 12,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   CDC2↓, 2,   CDC25↓, 1,   compI↓, 2,   EGF↓, 2,   ETC↓, 1,   ETC↑, 1,   Insulin↓, 4,   mitResp↓, 2,   mitResp↑, 1,   mtDam↑, 7,   OCR↓, 4,   OCR↑, 3,   mt-OCR↓, 1,   OXPHOS↓, 3,   OXPHOS↑, 6,   p‑PDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 2,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 3,   ALAT↑, 1,   ALDOA↓, 1,   AMP↑, 1,   AMPK↑, 16,   ATP↓, 10,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   CRM↑, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FASN↓, 2,   GAPDH↓, 1,   glucoNG↓, 1,   glucose↓, 2,   GlucoseCon↓, 5,   GlutMet↓, 1,   Glycolysis↓, 26,   Glycolysis↝, 1,   Glycolysis∅, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   H2S↑, 1,   HK2↓, 11,   HMG-CoA↓, 2,   lactateProd↓, 9,   LDHA↓, 4,   LDL↓, 1,   lipoGen↓, 1,   MCT4↓, 2,   MethCyc↓, 1,   NAD↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   NADPH↑, 2,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 4,   PDKs↓, 1,   PDKs↑, 1,   PFK↓, 4,   PKM2↓, 9,   polyA↓, 1,   PPP↓, 1,   PPP↑, 1,   Pyruv↓, 2,   SIRT1↓, 4,   SIRT1↑, 5,   SIRT2↓, 1,   TCA↓, 1,   TCA↑, 1,   TS↓, 2,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 102,   ASC↓, 1,   BAD↓, 1,   BAD↑, 3,   Bak↓, 1,   Bak↑, 3,   BAX↓, 3,   BAX↑, 34,   Bax:Bcl2↑, 11,   Bcl-2↓, 41,   Bcl-2↑, 1,   Bcl-xL↓, 8,   BID↓, 1,   BID↑, 2,   BIM↑, 2,   BNIP3↑, 1,   BNIP3↝, 1,   Casp↑, 17,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp12?, 1,   Casp3↓, 2,   Casp3↑, 45,   cl‑Casp3↑, 10,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp6↑, 1,   Casp7↑, 5,   Casp8↑, 11,   cl‑Casp8↑, 4,   Casp9↓, 1,   Casp9↑, 29,   cl‑Casp9↑, 5,   cFLIP↓, 1,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 36,   Diablo↑, 3,   DR5↑, 7,   Fas↑, 7,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 8,   GSDME↑, 1,   IAP1↓, 3,   IAP2/BIRC3↑, 1,   iNOS↓, 4,   iNOS↑, 1,   Mcl-1↓, 8,   MDM2↓, 5,   p‑MDM2↓, 1,   MOMP↑, 3,   Necroptosis↑, 1,   NOXA↑, 2,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 3,   Paraptosis↑, 1,   PUMA↑, 4,   Pyro↑, 1,   RIP1↑, 1,   RIP3↑, 1,   survivin↓, 15,   TRAIL↑, 3,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 12,   XIAP↓, 9,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 50,   Akt↑, 2,   p‑Akt↓, 13,   AMPKα↑, 1,   BRAF↓, 1,   p‑CaMKII ↓, 1,   CK2↓, 2,   cMET↓, 1,   cSrc↓, 2,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 14,   EGFR↑, 2,   ERK↓, 20,   ERK↑, 3,   p‑ERK↓, 4,   FGFR1↓, 3,   FGFR2↓, 1,   FOXD3↑, 2,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   IGF-1R↓, 2,   IKKα↓, 2,   IκB↓, 2,   IκB↑, 1,   JAK↓, 1,   JAK↝, 1,   JAK1↓, 4,   JAK2↓, 8,   JNK↓, 2,   JNK↑, 12,   p‑JNK↑, 2,   MAPK↓, 16,   MAPK↑, 6,   MEK↓, 3,   mTOR↓, 36,   mTOR↑, 1,   mTORC2↓, 2,   p70S6↓, 1,   P70S6K↓, 1,   P90RSK↓, 2,   PAK↓, 1,   PI3K↓, 38,   PI3K↑, 2,   p‑PI3K↓, 2,   PI3K/mTOR/ETS2↓, 1,   PIK3CA↓, 1,   PKCδ↓, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 13,   Raf↓, 3,   RAS↓, 6,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 7,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 27,   STAT3↑, 1,   p‑STAT3↓, 9,   STAT6↓, 2,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 6,   ATF4↝, 1,   cJun↓, 5,   cMyc↓, 15,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 5,   DNMT3A↓, 1,   DNMTs↓, 2,   EZH2↓, 1,   FOXO↑, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 1,   p‑FOXO3↓, 3,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 2,   H4↓, 1,   HDAC↓, 9,   HDAC1↓, 1,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC8↓, 1,   miR-143↑, 1,   miR-21↓, 1,   miR-30a-5p↑, 1,   miR-34a↑, 2,   miR-375↑, 1,   Myc↓, 4,   Myc↑, 1,   n-MYC↓, 2,   OCT4↓, 2,   other↓, 1,   other↑, 5,   other↝, 8,   PhotoS↑, 5,   Prot↓, 1,   sonoS↑, 2,   SOX2↓, 4,   SOX4↑, 1,   TCF-4↓, 2,   tumCV↓, 17,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 6,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↑, 25,   GRP78/BiP↓, 1,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 3,   HSP72↑, 1,   HSP90↓, 8,   HSPs↑, 2,   IRE1↑, 3,   PERK↑, 4,   Proteasome?, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 5,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 4,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 3,   LC3s↓, 1,   lysoMP↑, 1,   p62↓, 2,   p62↑, 2,   TumAuto↓, 2,   TumAuto↑, 21,   TumAuto↝, 2,   mt-TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BRCA2↓, 5,   BRCA2↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 4,   DNAdam↑, 51,   DNArepair↓, 8,   DNArepair↑, 1,   hTERT/TERT↓, 8,   P53↓, 1,   P53↑, 35,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 8,   cl‑PARP↑, 21,   PCNA↓, 5,   POLD1↓, 1,   SIRT6↑, 1,   Telomerase↓, 11,   TOP1↓, 6,   TOP2↓, 4,   TP53↓, 1,   TP53↑, 1,   γH2AX↑, 8,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 14,   CDK2↑, 1,   CDK4↓, 16,   CDK4↑, 1,   CDK6↓, 12,   CDK6↑, 1,   CDK8↓, 2,   Cyc↓, 2,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 26,   cycE/CCNE↓, 9,   E2Fs↓, 2,   GADD45A↑, 1,   Ki-67↓, 11,   mitA↑, 4,   P21↓, 2,   P21↑, 26,   p27/CDKN1B↑, 14,   RB1↓, 1,   p‑RB1↓, 4,   Securin↓, 2,   TubPol↓, 1,   TumCCA↓, 4,   TumCCA↑, 82,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   ALDH1A1↓, 1,   CD133↓, 2,   CD34↓, 1,   cFos↓, 5,   cFos↑, 1,   cMYB↓, 1,   CSCs?, 1,   CSCs↓, 28,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 5,   EIF4E↓, 1,   FGF↓, 2,   Gli1↓, 3,   HH↓, 5,   HMGCR↓, 2,   IGF-1↓, 5,   IGF-1↑, 1,   Ki-67↓, 11,   Let-7↑, 1,   LRP6↓, 1,   mTORC1↓, 7,   p‑mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 9,   NOTCH1↓, 3,   NOTCH1↑, 2,   NOTCH3↓, 1,   PTCH1↓, 1,   PTCH2↓, 1,   Shh↓, 6,   Smo↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG↓, 46,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 61,   TumCP↑, 1,   tyrosinase↓, 1,   Wnt↓, 19,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 4,   AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 16,   Ca+2↝, 1,   i-Ca+2↑, 1,   Cav1↓, 1,   Cdc42↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 16,   EMT↓, 37,   EMT↝, 1,   FAK↓, 3,   p‑FAK↓, 1,   Fibronectin↓, 1,   Furin↓, 1,   IQGAP3↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   KRAS↓, 1,   MALAT1↓, 4,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 3,   MMP13↓, 2,   MMP2↓, 32,   MMP7↓, 5,   MMP9↓, 33,   MMP9↑, 1,   MMPs↓, 8,   MUC4↓, 1,   N-cadherin↓, 10,   NEDD9↓, 1,   PAK1↓, 1,   PDGF↓, 1,   Rac1↓, 3,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 4,   Smad1↑, 1,   SMAD2↓, 1,   SMAD3↓, 3,   Snail↓, 8,   TET1↑, 2,   TGF-β↓, 8,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↑, 2,   TumCA↓, 1,   TumCI↓, 33,   TumCMig↓, 27,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 27,   TumMeta↑, 1,   Twist↓, 9,   Tyro3↓, 1,   uPA↓, 6,   Vim?, 1,   Vim↓, 13,   Vim↑, 1,   Zeb1↓, 4,   ZEB2↓, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 26,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 48,   angioG↑, 1,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 3,   Hif1a↓, 32,   Hif1a↑, 1,   Hypoxia↓, 7,   LOX1↓, 1,   NO↓, 1,   NO↑, 3,   NO↝, 1,   PHDs↓, 1,   TXA2↓, 1,   VCAM-1↓, 3,   VEGF↓, 46,   VEGFR2/KDR/Flk1↓, 7,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   CellMemb↑, 2,   CLDN1↓, 1,   CLDN2↓, 1,   CLDN2↑, 1,   EPR↑, 5,   EPR↝, 1,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   MMP↓, 41,   MMP↑, 2,   MPT↑, 3,   NHE1↓, 1,   TRPM7↓, 1,   TRPV1↓, 1,   TRPV1↝, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↑, 1,   CD44↓, 7,   CD8+↑, 1,   p‑cDC2↓, 1,   COX1↓, 4,   COX2/PTGS2↓, 39,   COX2/PTGS2↑, 3,   CXCR4↓, 5,   DCells↑, 1,   DR4↑, 1,   FOXP3↓, 2,   FOXP3↑, 1,   Gal-3↓, 1,   HCAR2↑, 1,   HLA↑, 1,   ICAM-1↓, 3,   IFN-γ↓, 2,   IFN-γ↑, 1,   Igs↑, 1,   IL1↑, 1,   IL10↓, 3,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 10,   IL2↓, 2,   IL2↑, 2,   IL4↓, 2,   IL6↓, 17,   IL8↓, 4,   IL8↑, 1,   Imm↑, 19,   Inflam↓, 21,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 74,   NF-kB↑, 5,   p‑NF-kB↓, 3,   p‑NF-kB↑, 1,   NK cell↑, 4,   NLRP3↓, 3,   p65↓, 4,   p65↑, 1,   p‑p65↓, 2,   PD-1↓, 3,   PD-1↝, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PGE2↓, 10,   PSA↓, 2,   RANTES↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   TCF↓, 2,   Th1 response↑, 2,   TLR4↓, 2,   TNF-α↓, 10,   TNF-α↑, 2,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,   pH↝, 3,   e-pH↓, 1,   e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   AKR1C3/17β-HSD5/PGF Synthase↓, 1,   AR↓, 7,   ER-α36↓, 2,   ER(estro)↓, 1,   Estro↝, 1,   PPARγ↓, 1,   PPARγ↑, 2,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 31,   BioAv↑, 30,   BioAv↝, 8,   BioEnh↑, 1,   CBR1↓, 1,   chemoR↓, 2,   ChemoSen?, 1,   ChemoSen↓, 5,   ChemoSen↑, 153,   ChemoSen⇅, 1,   ChemoSen∅, 2,   CompStab?, 1,   CompStab↓, 3,   CompStab↑, 4,   CompStab↝, 2,   CYP1A1↓, 1,   CYP3A4↓, 1,   Dose?, 4,   Dose↓, 2,   Dose↑, 9,   Dose↝, 36,   Dose∅, 8,   eff↓, 27,   eff↑, 85,   eff⇅, 1,   eff↝, 10,   GSTZ1↓, 1,   GSTZ1↝, 1,   Half-Life↓, 9,   Half-Life↑, 3,   Half-Life↝, 8,   MDR1↓, 7,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 9,   P450↓, 1,   P450↝, 1,   RadioS?, 3,   RadioS↓, 6,   RadioS↑, 304,   RadioS↝, 2,   RadioS∅, 2,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 64,   Synergy↑, 72,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALAT↑, 1,   ALP↓, 1,   AR↓, 7,   AST↓, 2,   AST↑, 1,   BG↓, 2,   BloodF↑, 4,   BRAF↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   CEA↓, 3,   CRP↓, 1,   EGFR↓, 14,   EGFR↑, 2,   EZH2↓, 1,   Ferritin↓, 2,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 8,   IL6↓, 17,   KRAS↓, 1,   LDH↓, 5,   LDH↑, 1,   LDH↝, 1,   Myc↓, 4,   Myc↑, 1,   NSE↓, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 2,   TP53↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↓, 1,   AntiCan↑, 23,   antiNeop↑, 1,   AntiTum↑, 13,   cachexia↓, 1,   cardioP↑, 5,   CardioT↓, 2,   chemoP↑, 20,   chemoPv↑, 7,   ChemoSideEff↓, 6,   CR↑, 1,   fatigue↓, 2,   hepatoP↑, 3,   hepatoP↝, 1,   LC↑, 1,   Mucositis↓, 1,   neuroP↑, 3,   NP/CIPN↓, 1,   NP/CIPN↑, 1,   OS↑, 20,   OS∅, 2,   Pain↓, 3,   PFS↓, 1,   PFS∅, 1,   QoL↑, 5,   QoL∅, 1,   radioP↑, 17,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 13,   Risk↑, 1,   Risk∅, 1,   Sleep↑, 1,   toxicity↓, 23,   toxicity↑, 3,   toxicity⇅, 1,   toxicity↝, 10,   toxicity∅, 5,   TumVol↓, 8,   TumW↓, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 2,   GutMicro↝, 2,   Sepsis↓, 1,  
Total Targets: 777

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 22,   Catalase↑, 12,   GPx↑, 10,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 17,   GSH/GSSG↑, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↑, 5,   Keap1↓, 1,   Keap1↑, 1,   ox-Keap1↑, 1,   lipid-P↓, 9,   MDA↓, 6,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 12,   ROS?, 1,   ROS↓, 34,   ROS↑, 2,   ROS↝, 1,   ROS∅, 2,   SOD↓, 1,   SOD↑, 13,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1,   OCR↑, 1,   OXPHOS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AMPK↑, 3,   ATP↑, 2,   glucose↓, 1,   GlucoseCon↑, 1,   LDL↓, 1,   lipidLev↓, 1,   NAD↑, 1,   NADPH↑, 1,   NADPH∅, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 3,   Casp9↓, 1,   Cyt‑c↓, 2,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   JNK↓, 1,   MAPK↓, 1,   PI3K↓, 2,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cMyc↑, 1,   other↑, 4,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   p300↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   Cartilage↑, 1,   FAK↑, 1,   MMP13↓, 1,   MMP9↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   HIF-1↓, 1,   NO↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   GastroP↑, 1,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 5,   CXCR4↓, 1,   IL10↑, 3,   IL17↓, 2,   IL18↓, 2,   IL1β↓, 6,   IL2↓, 1,   IL6↓, 7,   IL6↑, 1,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 28,   NF-kB↓, 3,   NLRP3↑, 1,   PGE2↓, 1,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 1,   GABA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 3,   BACE/β-secretase↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   GR↑, 1,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 13,   BioAv↑, 10,   BioAv↝, 4,   BioEnh↑, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 7,   eff↑, 4,   eff↝, 1,   GSTA1↓, 1,   Half-Life↓, 2,   Half-Life↝, 4,   Half-Life∅, 1,   RadioS↑, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↓, 1,   AST↓, 1,   creat↓, 1,   CRP↓, 3,   IL6↓, 7,   IL6↑, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 6,   AntiTum↓, 1,   cardioP↑, 13,   CardioT↓, 1,   chemoP↑, 3,   chemoPv↑, 6,   cognitive↑, 4,   hepatoP↑, 8,   memory↑, 4,   motorD↑, 2,   neuroP↑, 18,   Obesity↓, 2,   Pain↓, 2,   radioP↑, 8,   RenoP↑, 3,   Risk↓, 1,   Stroke↓, 1,   toxicity?, 1,   toxicity↓, 15,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 5,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 7,   Diar↓, 1,   GutMicro↑, 3,   Inf↓, 1,  
Total Targets: 175

Scientific Paper Hit Count for: RadioS, RadioSensitizer
93 Radiotherapy/Radiation
19 Curcumin
18 Hyperthermia
11 Silver-NanoParticles
9 Fisetin
8 Betulinic acid
8 Propolis -bee glue
8 Resveratrol
7 Baicalein
7 Magnetic Fields
6 Chemotherapy
6 Cisplatin
6 Berberine
6 salinomycin
6 diet Methionine-Restricted Diet
6 Ellagic acid
5 Copper and Cu NanoParticles
5 Dichloroacetate
5 Disulfiram
5 Gold NanoParticles
5 mebendazole
5 Melatonin
5 Thymoquinone
4 Atorvastatin
4 Chrysin
4 Honokiol
4 Oxygen, Hyperbaric
4 Luteolin
4 Phenylbutyrate
4 Sulforaphane (mainly Broccoli)
4 Selenium NanoParticles
4 Selenite (Sodium)
3 Selenium
3 Apigenin (mainly Parsley)
3 Ashwagandha(Withaferin A)
3 brusatol
3 Crocetin
3 Eugenol
3 diet FMD Fasting Mimicking Diet
3 Ferulic acid
3 Gambogic Acid
3 Kaempferol
3 Quercetin
3 Metformin
3 Piperlongumine
3 Parthenolide
3 Sulfasalazine
2 3-bromopyruvate
2 Auranofin
2 Allicin (mainly Garlic)
2 Anti-oxidants
2 Vitamin C (Ascorbic Acid)
2 Astaxanthin
2 Beta-Caryophyllene
2 Brucea javanica
2 Caffeic acid
2 Capsaicin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 chemodynamic therapy
2 Celastrol
2 diet Short Term Fasting
2 Diindolylmethane
2 immunotherapy
2 EGCG (Epigallocatechin Gallate)
2 Geldanamycin
2 Gossypol/AT-101
2 Magnolol
2 Methyl Jasmonate
2 methylseleninic acid
2 Niclosamide (Niclocide)
2 Oleuropein
2 Rosmarinic acid
2 Silymarin (Milk Thistle) silibinin
2 Vitamin D3
1 2-DeoxyGlucose
1 Astragalus
1 Alpha-Lipoic-Acid
1 Vitamin A, Retinoic Acid
1 Artemisinin
1 Aspirin
1 Baicalin
1 Berbamine
1 Biochanin A
1 Bromelain
1 borneol
1 Boron
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Zinc
1 Carvacrol
1 Thymol-Thymus vulgaris
1 carboplatin
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Coenzyme Q10
1 Cucurbitacin
1 Diclofenac
1 Electrical Pulses
1 Fenbendazole
1 Formononetin
1 Fucoidan
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Genistein (soy isoflavone)
1 Germanium inorganic
1 Ginkgolide B
1 Ginkgetin
1 Hydroxycinnamic-acid
1 Hyperoside
1 Indole-3-carbinol
1 Isoliquiritigenin
1 isoflavones
1 low dose naltrexone
1 Lycopene
1 Mung Bean Sprouts
1 MCT, metronomic chemo
1 Modified Citrus Pectin
1 Methylglyoxal
1 HydroxyTyrosol
1 Piperine
1 Psoralidin
1 doxorubicin
1 Oxaliplatin
1 Shikonin
1 Urolithin
1 Vitamin K2
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1107  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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