Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
1398- BBR,    Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage
- in-vitro, Kidney, NA
TumCP↓, TumCMig↓, ROS↑, Apoptosis↑, BAX↑, BAD↑, Bak↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, E-cadherin↑, TIMP1↑, γH2AX↑, Bcl-2↓, N-cadherin↓, Vim↓, Snail↓, RAD51↓, PCNA↓,
1395- BBR,    Analysis of the mechanism of berberine against stomach carcinoma based on network pharmacology and experimental validation
- in-vitro, GC, NA
Apoptosis↑, ROS↑, MMP↓, ATP↓, AMPK↑, TP53↑, p‑MAPK↓, p‑ERK↓,
1393- BBR,  EPI,    Berberine promotes antiproliferative effects of epirubicin in T24 bladder cancer cells by enhancing apoptosis and cell cycle arrest
- in-vitro, Bladder, T24/HTB-9
ChemoSen↑, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, P53↑, P21↑, Bcl-2↓, ROS↑,
1390- BBR,  Rad,    Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells
- in-vitro, Pca, PC3
RadioS↑, Apoptosis↑, ROS↑, eff↑, BAX↑, Casp3↑, P53↑, p38↑, JNK↑, Bcl-2↓, ERK↓, HO-1↓,
1389- BBR,  Lap,    Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS
- in-vitro, BC, BT474 - in-vitro, BC, AU-565
ChemoSen↑, Apoptosis↑, ROS↑, NRF2↓,
1387- BBR,    Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines
- in-vitro, Thyroid, CAL-62
TumCG↓, Apoptosis↑, LC3B↑, ROS↑, PI3K↓, Akt↓, mTOR↓,
1384- BBR,    Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines
- in-vitro, PC, PANC1
TumCCA↑, ROS↑, Apoptosis↑,
1374- BBR,  PDT,    Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells
- in-vitro, RCC, 786-O - in-vitro, RCC, HK-2
ROS↑, TumAuto↑, Apoptosis↑, Casp3↑, eff↑,
1377- BBR,    Berberine inhibits autophagy and promotes apoptosis of fibroblast-like synovial cells from rheumatoid arthritis patients through the ROS/mTOR signaling pathway
- in-vitro, Arthritis, NA
Apoptosis↑, MMP↓, Bax:Bcl2↑, LC3‑Ⅱ/LC3‑Ⅰ↓, p62↑, *ROS↓,
1378- BBR,    Berberine induces non-small cell lung cancer apoptosis via the activation of the ROS/ASK1/JNK pathway
- in-vitro, Lung, NA
Apoptosis↑, Casp3↑, Cyt‑c↑, MMP↓, p‑JNK↑, eff↓,
1379- BBR,    Berberine derivative DCZ0358 induce oxidative damage by ROS-mediated JNK signaling in DLBCL cells
- in-vitro, lymphoma, NA
TumCP↓, CDK4↓, CDK6↓, cycD1/CCND1↓, TumCCA↑, MMP↓, Ca+2↑, ATP↓, mtDam↑, Apoptosis↑, ROS↑, JNK↑, eff↓,
1381- BBR,  Rad,    Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3)
- in-vitro, Ovarian, SKOV3
RadioS↑, ROS↑, GSH↓, Apoptosis↑,
1382- BBR,    Berberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cells
- in-vitro, Melanoma, SK-MEL-28
Apoptosis↑, necrosis↑, DNAdam↑, TumCCA↑, ROS↑, Casp3↑, p‑P53↑, ERK↑,
1400- BBR,    Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells
- in-vitro, Melanoma, U266
ROS↑, TumCCA↑, Apoptosis↑, miR-21↓, Bcl-2↓, NF-kB↓, Set9↑,
1401- BBR,    Berberine induces apoptosis in glioblastoma multiforme U87MG cells via oxidative stress and independent of AMPK activity
- in-vitro, GBM, U87MG
TumCP↓, Apoptosis↑, ROS↑,
1399- BBR,  Rad,    Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review
- Review, NA, NA
*ROS↓, *MDA↓, *TNF-α↓, *TGF-β↓, *IL10↑, ROS↑, DNAdam↑, mtDam↑, MMP↓, Apoptosis↑, TumCCA↑, Hif1a↓, VEGF↓, RadioS↑,
1404- BBR,    Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation
- in-vitro, Pca, PC3
Apoptosis↑, *Apoptosis∅, MMP↓, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, ROS↑, eff↓, Cyt‑c↑,
2692- BBR,    Berberine affects osteosarcoma via downregulating the caspase-1/IL-1β signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, SaOS2 - in-vivo, NA, NA
Casp1↓, IL1β↓, TumCG↓, Dose↝, Apoptosis↑, Inflam↓,
2709- BBR,    Berberine inhibits the glycolysis and proliferation of hepatocellular carcinoma cells by down-regulating HIF-1α
- in-vitro, HCC, HepG2
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Glycolysis↓, Hif1a↓, GLUT1↓, HK2↓, PKM2↓, LDHA↓,
2711- BBR,    Berberine inhibits the progression of breast cancer by regulating METTL3-mediated m6A modification of FGF7 mRNA
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, FGF↓, IGFBP3↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2681- BBR,  PDT,    Berberine-photodynamic induced apoptosis by activating endoplasmic reticulum stress-autophagy pathway involving CHOP in human malignant melanoma cells
- in-vitro, Melanoma, NA
Apoptosis↑, cl‑Casp3↑, LC3s↑, ER Stress↑, ROS↑, CHOP↑,
2682- BBR,    Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480 - in-vitro, CRC, HCT116
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, necrosis↑, AQPs↓, PTEN↑, PI3K↓, Akt↓, p‑Akt↓, mTOR↓, p‑mTOR↓,
2685- BBR,    Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells
- in-vitro, neuroblastoma, NA
CSCs↓, CD133↓, β-catenin/ZEB1↓, n-MYC↓, SOX2↓, NOTCH2↓, Nestin↓, TumCCA↑, TumCP↓, CDK1↓, Cyc↓, Apoptosis↑, Bax:Bcl2↑, NCAM↓, MMP2↓, MMP9↓, *Smad1↑, *HSP70/HSPA5↑, *LAMs↑,
3678- BBR,    Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
- Review, AD, NA
*APP↓, *PPARγ↑, *NF-kB↓, *Aβ↓, *cognitive↑, *antiOx↑, *Inflam↓, *Apoptosis↓, *BioAv↑, *BioAv↝, *BBB↑, *motorD↑, *NRF2↑, *HO-1↑, *ROS↓, *p‑Akt↑, *p‑ERK↑,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
3682- BBR,    Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *Apoptosis↓, *CD31↑, *VEGF↑, *N-cadherin↑, *angioG↑, *neuroP↑, *p‑tau↓, *antiOx↑, *AChE↓, *MAOB↓, *lipid-P↓,
1092- BBR,    Berberine as a Potential Anticancer Agent: A Comprehensive Review
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumAuto↑, TumCI↓, IL1↓, IL6↓, TNF-α↓, LDH↓, P2X7↓, proCasp1↓, Casp1↓, ASC↓,
5548- BBR,    Berbamine induces SMMC-7721 cell apoptosis via upregulating p53, downregulating survivin expression and activating mitochondria signaling pathway
- in-vitro, HCC, SMMC-7721 cell
TumCG↓, Apoptosis↑, Cyt‑c↑, BAX↑, P53↑, Bcl-2↓, survivin↓,
4658- BBR,    Berberine Suppresses Stemness and Tumorigenicity of Colorectal Cancer Stem-Like Cells by Inhibiting m6A Methylation
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
CSCs↓, TumCP↓, cycD1/CCND1↓, p27↑, P21↑, TumCCA↑, Apoptosis↑, ChemoSen↑, β-catenin/ZEB1↓, FTO↑, CD44↓, CD133↓, ChemoSen↑,
5178- BBR,    Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, Apoptosis↑, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, PARP↑, DNAdam↑, selectivity↑, Cyt‑c↑,
5177- BBR,    Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway
- in-vitro, Oral, HMC3
TumCCA↑, Apoptosis↑, TumCG↓, Casp3↑, TumCCA↑, ROS↑, Ca+2↑, MMP↓, ER Stress↑, Cyt‑c↑,
5180- BBR,    Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth
- in-vitro, NSCLC, NA
TumCMig↓, TumCP↓, Apoptosis↑, TFAP2A↓, hTERT/TERT↓, NF-kB↓, COX2↓, Hif1a↓, VEGF↓, Akt↓, p‑ERK↓, Cyt‑c↑, cl‑Casp↑, cl‑PARP↑, PI3K↓, Akt↓, Raf↓, MEK↓, ERK↓,
1473- BCA,  SFN,    An Insight on Synergistic Anti-cancer Efficacy of Biochanin A and Sulforaphane Combination Against Breast Cancer
- in-vitro, BC, MCF-7
eff↑, ROS↑, other↑, ERK↓, Apoptosis↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE↓, *memory↑, *BioAv↓,
5634- BCA,    Molecular Mechanisms of Biochanin A in AML Cells: Apoptosis Induction and Pathway-Specific Regulation in U937 and THP-1
- in-vitro, AML, U937 - in-vitro, AML, THP1
Apoptosis↑, Casp7↑, PARP1↑, Bcl-2↓, Myc↓, CHOP↑, P21↑, p62↑, TumCCA↑, TXNIP↑, ROS↑, *antiOx↑, *Inflam↓, *neuroP↑, AntiCan↑, TumCP↓, angioG↓, TumMeta↓, VEGF↓, MMPs↓, tumCV↓, DNAdam↑, CHOP↑, cMyc↓, BioAv↓, Half-Life↓, BioAv↑,
5636- BCA,    Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells
- vitro+vivo, Lung, A549
tumCV↓, TumCCA↑, Apoptosis↑, MMP↓, TumCG↓, P21↑, Casp3↑, Bcl-2↑,
5637- BCA,  ATV,    Combination Treatment of Biochanin A and Atorvastatin Alters Mitochondrial Bioenergetics, Modulating Cell Metabolism and Inducing Cell Cycle Arrest in Pancreatic Cancer Cells
- in-vitro, PC, AsPC-1 - in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2
eff↑, TumCI↓, STAT3↓, Apoptosis↑,
5638- BCA,    Investigating the Anticancer Potential of Biochanin A in KB Oral Cancer Cells Through the NFκB Pathway
- in-vitro, Oral, NA
tumCV↓, ROS↑, MMP↓, TumCMig↓, TAC↓, lipid-P↓, NF-kB↓, Apoptosis↑,
5639- BCA,    Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition
- in-vitro, BC, NA
TumCP↓, ROS↑, Apoptosis↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, CycD3↓, CycB/CCNB1↓, CDK1↓, CDK2↓, CDK4↓, P21↑, p27↑, P53↑, tumCV↓, PI3K↓, Akt↓,
6513- BCP,    β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products
Apoptosis↑, TumCG↓, TumMeta↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, IAP1↓, IAP2↓, Bcl-2↓, Bcl-xL↓, survivin↓, COX2↓, cycD1/CCND1↓, cMyc↓, TumCI↓, MMP9↓, ICAM-1↓, angioG↓, VEGF↓, NF-kB↓,
6517- BCP,    β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways
- in-vivo, Nor, NA
*cardioP↑, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *TLR4↓, *NF-kB↓, *Inflam↓, *Apoptosis↓,
6512- BCP,    Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells
- in-vitro, MM, NA
CB2 / CNR2↑, BAX↑, Bcl-2↓, Casp3↑, TumCP↓, Apoptosis↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Inflam↓, chemoPv↑, neuroP↑, *BioAv↝, CB2 / CNR2↑, tumCV↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
6499- BCP,    JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation
- in-vitro, OS, MG63
ROS↑, Apoptosis↑, TumCP↓, BAX↑, Casp3↑, Bcl-2↓, MMP↓, DNAdam↑, TNF-α↓, COX2↓, NF-kB↓, IL6↓, Inflam↓, JAK1↑, STAT3↑,
6500- BCP,    Beta-Caryophyllene Suppresses Ovarian Cancer Proliferation by Inducing Cell Cycle Arrest and Apoptosis
- in-vitro, Ovarian, NA
TumCP↓, TumCCA↑, Apoptosis↑, Casp3↑, cl‑PARP↑,
6501- BCP,    β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study
- in-vitro, Oral, KB
TumCG↓, Apoptosis↑, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, ROS↑, MMP↓, DNAdam↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, PCNA↓, cycD1/CCND1↓, TNF-α↓, COX2↓, iNOS↓, IL6↓, VEGF↓,
6498- BCP,    β-Caryophyllene induces apoptosis and inhibits cell proliferation by deregulation of STAT-3/mTOR/AKT signaling in human bladder cancer cells: An in vitro study
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, 5637
tumCV↓, ROS↑, Apoptosis↑, MMP↓, TumCMig↓, STAT3↓, mTOR↓, Akt↓,
6497- BCP,  Cisplatin,    Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules
- in-vitro, Lung, NA
TumCG↓, TumCP↓, Apoptosis↑, toxicity↓, ChemoSen↑, P21↑, Bcl-xL↑, Bcl-2↓, EMT↓, E-cadherin↑, eff↑, MMP↓,
6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, VEGF↓, TumVol↓, Apoptosis↑, HSPD1 / HSP60↓, HTRA↓, survivin↓, XIAP↓, P21↑, *toxicity↓, *neuroP↑, *ROS↓, *COX2↓, *Inflam↓, *cardioP↑, AntiCan↑, ChemoSen↑, ROS↑, MMP↑, Bax:Bcl2↑, TumCG↓,

Showing Research Papers: 251 to 300 of 1398
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1398

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

AntiBio↓, 1,   CB2 / CNR2↑, 3,   HSPD1 / HSP60↓, 1,   HTRA↓, 1,  

Redox & Oxidative Stress ⓘ

GSH↓, 1,   HO-1↓, 1,   lipid-P↓, 1,   NRF2↓, 1,   ROS↑, 30,   TAC↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   CDC25↓, 2,   MEK↓, 1,   MMP↓, 15,   MMP↑, 1,   mtDam↑, 2,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   cMyc↓, 2,   Glycolysis↓, 1,   HK2↓, 1,   LDH↓, 1,   LDHA↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 9,   p‑Akt↓, 3,   Apoptosis↑, 46,   BAD↑, 1,   Bak↑, 1,   BAX↑, 10,   Bax:Bcl2↑, 4,   Bcl-2↓, 14,   Bcl-2↑, 2,   Bcl-xL↓, 2,   Bcl-xL↑, 1,   Casp↑, 1,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   proCasp1↓, 1,   Casp3↓, 1,   Casp3↑, 13,   cl‑Casp3↑, 4,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 4,   cl‑Casp9↑, 3,   Cyt‑c↑, 9,   Fas↑, 1,   FasL↑, 1,   hTERT/TERT↓, 1,   IAP1↓, 2,   IAP2↓, 1,   iNOS↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 2,   p‑MAPK↓, 1,   MDM2↓, 1,   Myc↓, 1,   necrosis↑, 2,   p27↑, 3,   P2X7↓, 1,   p38↑, 1,   p‑p38↓, 1,   Set9↑, 1,   survivin↓, 4,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,   other↓, 1,   other↑, 1,   tumCV↓, 6,  

Protein Folding & ER Stress ⓘ

CHOP↑, 3,   ER Stress↑, 2,  

Autophagy & Lysosomes ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3B↑, 1,   LC3II↑, 1,   LC3s↑, 1,   p62↑, 2,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↑, 6,   DNArepair↓, 1,   P53↑, 5,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 4,   PARP1↑, 1,   PCNA↓, 2,   RAD51↓, 1,   TP53↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK2↓, 2,   CDK4↓, 3,   Cyc↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 5,   CycD3↓, 1,   cycE/CCNE↓, 1,   P21↑, 9,   RB1↑, 1,   TFAP2A↓, 1,   TumCCA↑, 19,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 2,   CD44↓, 1,   CSCs↓, 2,   EMT↓, 1,   EMT↑, 1,   ERK↓, 4,   ERK↑, 1,   p‑ERK↓, 3,   FGF↓, 1,   GSK‐3β↓, 1,   IGFBP3↑, 1,   mTOR↓, 6,   p‑mTOR↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH2↓, 1,   PI3K↓, 7,   p‑PI3K↓, 1,   PTEN↑, 1,   RAS↓, 1,   SOX2↓, 1,   STAT3↓, 4,   STAT3↑, 1,   TumCG↓, 9,   Wnt↓, 1,  

Migration ⓘ

Ca+2↑, 2,   E-cadherin↓, 1,   E-cadherin↑, 2,   FAK↓, 1,   FTO↑, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 4,   MMP3↓, 1,   MMP9↓, 4,   MMPs↓, 2,   N-cadherin↓, 1,   NCAM↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TumCI↓, 8,   TumCMig↓, 7,   TumCP↓, 16,   TumCP↑, 2,   TumMeta↓, 6,   TXNIP↑, 1,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 1,   EPR↑, 1,   Hif1a↓, 4,   VEGF↓, 8,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

AQPs↓, 1,   GLUT1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   CD4+↓, 1,   COX2↓, 6,   ICAM-1↓, 1,   IL1↓, 2,   IL1β↓, 2,   IL6↓, 5,   Inflam↓, 5,   JAK1↑, 1,   MCP1↓, 1,   NF-kB↓, 9,   PGE2↓, 1,   TNF-α↓, 5,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 1,   ChemoSen↑, 10,   Dose↝, 2,   eff↓, 3,   eff↑, 8,   Half-Life↓, 1,   MRP1/ABCC1↓, 1,   RadioS↑, 5,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   hTERT/TERT↓, 1,   IL6↓, 5,   LDH↓, 1,   Myc↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 2,   chemoP↑, 1,   chemoPv↑, 1,   neuroP↑, 1,   Pain↓, 1,   RenoP↑, 1,   toxicity↓, 1,   TumVol↓, 1,  
Total Targets: 204

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 6,   Catalase↑, 1,   GPx↑, 2,   HO-1↑, 2,   lipid-P↓, 3,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 4,   ROS↓, 8,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

PPARγ↑, 1,  

Cell Death ⓘ

Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↓, 4,   Apoptosis∅, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,   HSP90↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 2,   mTOR↓, 1,   P70S6K↓, 1,  

Migration ⓘ

APP↓, 2,   CD31↑, 2,   LAMs↑, 1,   N-cadherin↑, 2,   Smad1↑, 1,   TGF-β↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   VEGF↑, 2,  

Barriers & Transport ⓘ

BBB↑, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL10↑, 1,   Inflam↓, 6,   NF-kB↓, 3,   TLR4↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 3,   BACE↓, 1,   MAOB↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 2,   BioEnh↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALP↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 3,   cognitive↑, 3,   hepatoP↑, 1,   memory↑, 2,   motorD↑, 1,   neuroP↑, 6,   Obesity↓, 1,   toxicity↓, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 58

Scientific Paper Hit Count for: Apoptosis, Apoptosis
68 Curcumin
67 Silver-NanoParticles
43 Magnetic Fields
41 Quercetin
36 Thymoquinone
34 Berberine
31 Sulforaphane (mainly Broccoli)
31 EGCG (Epigallocatechin Gallate)
29 Baicalein
25 Ashwagandha(Withaferin A)
25 Capsaicin
25 Shikonin
23 Betulinic acid
23 Phenethyl isothiocyanate
22 Resveratrol
20 Radiotherapy/Radiation
19 Artemisinin
19 Apigenin (mainly Parsley)
19 Boron
19 Chrysin
19 Selenite (Sodium)
18 Dandelion Root
18 Honokiol
18 Lycopene
18 Urolithin
17 Garcinol
16 Eugenol
15 Chemotherapy
15 Carvacrol
15 Nimbolide
14 Cisplatin
14 Astaxanthin
14 chitosan
14 Crocetin
14 Luteolin
13 Beta-Caryophyllene
13 salinomycin
13 Magnolol
12 Allicin (mainly Garlic)
12 Graviola
12 Selenium NanoParticles
11 Propolis -bee glue
11 Silymarin (Milk Thistle) silibinin
11 Gambogic Acid
10 Copper and Cu NanoParticles
10 Vitamin C (Ascorbic Acid)
10 Alpha-Lipoic-Acid
10 Metformin
10 Chlorogenic acid
10 Phenylbutyrate
10 Piperlongumine
9 α-Bisabolol / Chamomile oil
9 Selenium
9 Cucurbitacin
9 Fisetin
9 Juglone
9 Rosmarinic acid
8 Photodynamic Therapy
8 5-fluorouracil
8 Coenzyme Q10
8 Auranofin
8 Paclitaxel
8 Bufalin/Huachansu
8 Citric Acid
8 Carvone
8 Electrical Pulses
8 Ursolic acid
8 Dichloroacetate
8 Magnetic Field Rotating
7 Gemcitabine (Gemzar)
7 Atorvastatin
7 doxorubicin
7 Biochanin A
7 borneol
7 Boswellia (frankincense)
7 Caffeic acid
7 Carnosic acid
7 Cinnamon
7 Emodin
7 HydroxyTyrosol
7 Vitamin K2
6 Astragalus
6 Andrographis
6 Celecoxib
6 D-limonene
6 Ellagic acid
6 Hydrogen Gas
6 Piperine
6 Parthenolide
6 Terpinen-4-ol / Tea Tree Oil
5 Anethole/trans-Anethole
5 immunotherapy
5 Melatonin
5 Thymol-Thymus vulgaris
5 Celastrol
5 Chlorophyllin
5 Aflavin-3,3′-digallate
5 Genistein (soy isoflavone)
5 Plumbagin
5 Pterostilbene
4 1,8-Cineole
4 3-bromopyruvate
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Disulfiram
4 Eurycomanone
4 Ferulic acid
4 Ginkgo biloba
4 Geraniol
4 γ-linolenic acid (Borage Oil)
4 Linalool
4 Spermidine
3 2-DeoxyGlucose
3 tamoxifen
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Cat’s Claw
3 Cannabidiol
3 Cyclopamine
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Fennel Oil/Foeniculum vulgare
3 Galloflavin
3 Orlistat
3 Hyperthermia
3 Methyl salicylate / Sweet Birch oil
3 Magnesium
3 Naringin
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 α-Santalol/Sandalwood oil
3 Taurine
3 VitK3,menadione
3 Zerumbone
2 cetuximab
2 5-Aminolevulinic acid
2 Fenbendazole
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 DTS(dibenzyl trisulphide) from Anamu
2 Aspirin
2 Sorafenib (brand name Nexavar)
2 Dipyridamole
2 Aloe anthraquinones
2 beta-glucans
2 Docetaxel
2 Bortezomib
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Chocolate
2 irinotecan
2 CUSP9
2 Deguelin
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 Fucoidan
2 Shilajit/Fulvic Acid
2 Ginger/6-Shogaol/Gingerol
2 HydroxyCitric Acid
2 Methylglyoxal
2 Oleuropein
2 Oleocanthal
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Rutin
2 Sulfasalazine
2 polyethylene glycol
2 Vitamin D3
1 5-Hydroxytryptophan
1 Glucose
1 entinostat
1 Trichostatin A
1 Radio Frequency
1 Acetyl-l-carnitine
1 Amodiaquine
1 temozolomide
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Beta‐Lapachone
1 Selenate
1 Prebiotic
1 Choline
1 Hydroxycinnamic-acid
1 Vitamin E
1 Carica papaya leaf extract
1 Camptothecin
1 chemodynamic therapy
1 methylseleninic acid
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 Mistletoe
1 Lemongrass Extract/Citral
1 Evodiamine
1 Exercise
1 Gallic acid
1 carboplatin
1 gefitinib, erlotinib
1 Grapeseed extract
1 hydrogen sulfide
1 Rapamycin
1 Huperzine A/Huperzia serrata
1 Indole-3-carbinol
1 Inoscavin A
1 Ivermectin
1 Licorice
1 Lutein
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Lion’s Mane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Proanthocyanidins
1 isoflavones
1 Vorinostat
1 Oxaliplatin
1 Scoulerine
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Turmerones
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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