IL6 Cancer Research Results

IL6, Interleukin-6: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Interleukin-6 (IL-6) is a cytokine that plays a significant role in inflammation and the immune response. It is produced by various cell types, including T cells, B cells, macrophages, and fibroblasts.
IL-6 can promote tumor cell proliferation and survival. Many cancer cells produce IL-6, which can create an autocrine loop that supports their growth.
IL-6 is a high-value inflammatory biomarker in cancer, reporting cytokine burden, catabolic stress, and STAT3-linked survival signaling. While not tumor-specific, elevated and rising IL-6 strongly predicts poor prognosis and limited treatment tolerance, making it an important system-state indicator alongside CRP and ferritin.


Scientific Papers found: Click to Expand⟱
7629- Ins,    Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol
- in-vivo, Lung, NA
AntiCan↑, TumVol↓, PI3K↓, IL6↓, p‑STAT3↓, chemoPv↑,
7702- IP6,  Ins,  capec,    Inositol Hexakisphosphate and Inositol Enhance the Inhibition of Colorectal Cancer Growth and Liver Metastasis by Capecitabine in a Mouse Model
- in-vivo, CRC, NA
Dose↝, AntiTum↑, OS↑, TumW↓, TumMeta↓, E-cadherin↑, N-cadherin↓, Vim↓, TNF-α↓, IL6↓, IL8↓, ChemoSen↑,
7760- ISL,    Pharmacological Potentials and Delivery Strategies of Isoliquiritigenin: Challenges and Advances in Enhancing Bioavailability
- Review, Nor, NA
*BioAv↓, GlucoseCon↓, LDH↓, PDK1 / PDPK1↓, Glycolysis↓, mt-OXPHOS↓, Bax:Bcl2↓, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, Hif1a↓, ROS↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *ROS↓, *NF-kB↓, *NLRP3↓, *Pyro↓, *antiPs↑, *IL6↓, *IL8↓, CompStab↑, BioAv↑, BioAv↑,
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7780- ISL,    Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response
- in-vivo, Nor, NA
*hepatoP↑, *ROS↓, *PGC-1α↝, *NRF2↑, *HO-1↑, *NQO1↝, *Keap1↝, *GCLC↝, *GCLM↝, *NLRP3↓, *IL1β↓, *IL6↓, *TNF-α↓, *MIP2↓, *Bax:Bcl2↓, *cl‑Casp3↓, *Inflam↓, *Apoptosis↓,
7779- ISL,    Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury
- in-vivo, Alcohol, NA
*hepatoP↑, *FAM↑, *PGC-1α↑, *PPARα↑, *CPT1A↑, *ACADS/SCAD↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *miR-23a-3p↓,
7861- isoO,    Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *GSK‐3β↓, *TNF-α↓, *IL6↓, *IL1β↓, *p‑GSK‐3β↑, *Synergy↑, *COX2/PTGS2↓, *ERK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *OCLN↑, *ZO-1↑, *BBB↝,
7864- isoO,    Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
- in-vitro, AD, BV2
*iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *ROS↓, *NF-kB↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *cl‑Casp9↓, *cl‑Casp3↓, *cl‑PARP↓, *NeuroI↓,
7883- isoO,    Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *5LO↓, *IL1β↓, *Catalase↑, *GSTs↑,
7884- isoO,    Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome
- in-vitro, Nor, RAW264.7
*TNF-α↓, *IL6↓, *IL1β↓, *IL18↓, *PGE2↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓,
7886- isoO,    Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo
- vitro+vivo, Nor, NA
*TNF-α↓, *IL6↓, *NF-kB↓, *ERK↓,
7875- isoO,    Isoorientin Inhibits Amyloid β25–35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
- in-vitro, Nor, BV2
*iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *ROS↓, *NF-kB↓,
7874- isoO,    Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways
- in-vivo, Nor, NA
*ROS↓, *IL6↓, *NRF2↑, *HO-1↑, *Keap1↓, *NOD1↓, *NLRP3↓, *Casp1↓, *ASC↓, *IL1β↓, *Apoptosis↓,
7837- ISQ,    Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation
- in-vivo, Nor, NA
*Dose↝, *autophagy↓, *ATG7↓, *BNIP3↓, *LC3B↓, *PINK1↓, *ROS↓, *SOD1↑, *SOD2↑, *NRF2↑, *NQO1↑, *HO-1↑, *NOX2↓, *NOX4↓, *DUOX1↓, *IL1β↓, *IL6↓, *TNF-α↓, *JAK↓, *STAT3↓, *Inflam↓,
8034- IVM,  doxoR,    Synergistic potential of Ivermectin and doxorubicin in oral squamous cell carcinoma: an in vitro investigation
- in-vitro, Oral, NA
tumCV↓, selectivity↑, TumCCA↑, Apoptosis↓, BAX↑, Casp3↑, P53↑, Bcl-2↓, Ki-67↓, IL6↓, ROS↑, mtDam↑,
7917- IVT,    A review on the pharmacological effects of vitexin and isovitexin
- Review, Nor, NA - Review, AD, NA
*antiOx↑, *AntiCan↑, *Inflam↓, *neuroP↑, *AChE↓, *BChE↓, *BACE/β-secretase↓, *Stroke↓, *AntiAg↓, *AntiDiabetic↑, *AGEs↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *Obesity↓, *BioAv↝, *BioAv↓,
7904- IVT,    Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress
- in-vivo, Nor, NA
*cardioP↑, *IL1β↓, *IL6↓, *TNF-α↓, *NQO1↑, *NRF2↑, *SIRT3↑, *NOX2↓, *ROS↓,
7890- IVT,    Isovitexin protects against cisplatin-induced kidney injury in mice through inhibiting inflammatory and oxidative responses
- in-vivo, Nor, NA
RenoP↑, *BUN↓, *creat↓, *TNF-α↓, *IL1β↓, *IL6↓, *MDA↓, *ROS↓, *NF-kB↓, *NRF2↑, *HO-1↑,
5119- JG,    Juglone Suppresses Inflammation and Oxidative Stress in Colitis Mice
- in-vivo, Nor, NA
*antiOx↑, *OS↑, *IL6↓, *IL12↓, *IL23↓, *TNF-α↓, *Inflam↓, *NF-kB↓, *NFE2L2↓, *ROS↓,
4007- K+,    The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease
- in-vivo, AD, NA
*p‑tau↓, *cognitive↑, *Inflam↓, *ROS↓, *IL6↓, *4-HNE↓, *other↝,
8104- KAE,    A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF-κB inhibition and Nrf2 activation
- Review, Nor, NA
*ROS↓, *Inflam↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *NF-kB↓, *hepatoP↑, *RenoP↑, *cardioP↑, *neuroP↑,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
9007- L-THE,    L-theanine's therapeutic effects on colorectal cancer: Mechanistic insights from a 1,2-dimethylhydrazine-induced rat model
- in-vivo, CRC, NA
CRP↓, AFP↓, CEA↓, CA19-9↓, Ki-67↓, Apoptosis↑, Casp3↑, cl‑Casp3↑, BAX↑, Bcl-2↓, *ROS↓, *Inflam↓, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *IL1β↓, *TNF-α↓, *IL6↓, *IL10↓, *COX2/PTGS2↓, *NF-kB↓, *NLRP3↓, *GutMicro↑, *chemoPv↑, *Dose↝, Ki-67↓,
8154- lamb,    Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells
- in-vitro, Nor, NA
*IL6↓, *PGD2↓, *LTC4↓, *COX2/PTGS2↓, *β-HEX↓, *antiAll↑,
8151- lamb,    Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid
- in-vitro, BC, MCF7 - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCCA↑, cl‑PARP↑, p‑STAT3↓, NF-kB↓, XIAP?, survivin↓, Bcl-2↓, Bcl-xL↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ac‑p65↑, Obesity↓, miR-134↑,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8157- lamb,    Pinus koraiensis leaf extract and lambertianic acid attenuate fatigue and improve endurance capacity via PI3K-mediated regulation of oxidative stress and mitochondrial biogenesis
- in-vivo, Nor, NA
*fatigue↓, *ROS↓, *NF-kB↓, *IL6↓, *SOD↑, *PI3K↑, *NRF2↑, *HO-1↑, *SIRT1↑, *PGC-1α↑, *Nrf1↑, *Strength↑,
8221- LCA,    Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects
- in-vitro, Nor, NA
*Inflam↓, *AntiBio↑, *PGE2↓, *IL6↓, *TNF-α↓,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
8268- LE,    Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer
- vitro+vivo, CRC, NA
AntiTum↑, IL6↓, CCN2/CTGF↓, Inflam↓, HMGB1↓, DNAdam↓, CSCs↓, TLR4↓, NF-kB↓,
8145- LF,    Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review
- Review, AD, NA - Review, Park, NA
*AntiBio↑, *Imm↑, *AntiCan↑, *neuroP↑, *BBB↑, *APOE4↓, *ROS↓, *Inflam↓, *Apoptosis↓, *Learn↑, *memory↑, *ADAM10↑, *PSEN1/PS1↑, *cl‑APP↑, *BACE/β-secretase↓, *cognitive↑, *MDA↓, *IL6↓, *TNF-α↓, *neuroP↑, *Dose↝, *IronCh↑, *SOD↑, *BioAv↝,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8144- LF,    A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway
- Human, AD, NA
*Ach↑, *5HT↑, *TAC↑, *Inflam↓, *Akt↑, *PI3K↑, *Aβ42↓, *LDL↓, *ROS↓, *IL6↓, *HSP90↓, *Casp3↓, *tau↓, *MAPK↓, *PTEN↓, *cognitive↑, *Dose↝,
8311- lign,    The Power of Lignans: Plant Compounds with Multifaceted Health-Promoting Effects
- Review, Nor, NA
*cardioP↑, *AntiDiabetic↑, *Obesity↓, *Bacteria↓, *AntiFungal↑, *AntiViral↑, *neuroP↑, *antiOx↑, *lipid-P↓, *memory↑, *CREB↑, *BDNF↑, *PSD95↑, *β-Amyloid↓, *TNF-α↓, *IL6↓, *IL10↓, *GutMicro↑, *Endoglin↑, *END↑, *cognitive↑, *Akt↓, *IκB↓, *NF-kB↓, *HO-1↑, *VEGF↑, *p‑eNOS↑, *GRP78/BiP↓, *PERK↓, *ATF4↓, *CHOP/DDIT3↓, *SREBP1/SREBF1↓, *ROS↓, TumVol↓,
8320- LIN,    Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways
- in-vivo, Nor, NA
RenoP↑, Dose↝, *TLR4↓, *MyD88↓, *TRIF↓, *TNF-α↓, *IL1β↓, *IL6↓, *NF-kB↓, *chemoP↑, *Casp3↓, *Casp9↓, *BAX↓, *Bcl-2↑, ChemoSen↑, *cardioP?, *hepatoP↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *ROS↓, *BUN?, *creat↓, *GSH↑, *SOD↑, *Catalase↑, *MDA↓, *NADPH↓, *NRF2↑, *HO-1↑,
8318- LIN,    Linalool Exhibits Cytotoxic Effects by Activating Antitumor Immunity
- in-vitro, BC, T47D - NA, CRC, SW-620 - NA, Liver, HepG2
TumCCA↑, IFN-γ↓, IL13↓, IL2↓, IL4↓, IL6↓, TNF-α↓, Th1 response?,
6482- LIN,    Pharmacological and molecular insights into linalool-rich Coriandrum sativum essential oil: Anticonvulsant, analgesic, anti-inflammatory, and antioxidant potential in rodent models
- Review, Nor, NA
IL1β↓, IL6↓, hepatoP↑, Inflam↓,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,
8385- LT,    Luteolin regulates pyroptosis of triple-negative breast cancer cells through AKT signaling
- vitro+vivo, BC, MDA-MB-231
Pyro↑, Akt↓, GSDMD↑, NLRP3↑, IL1β↓, IL6↓, TNF-α↓, PCNA↓, Ki-67↓,
8390- LT,    Luteolin in Inflammatory Bowel Disease and Colorectal Cancer: A Disease Continuum Perspective
- Review, IBD, NA - Review, CRC, NA
*Diff↝, *Inflam↓, *ROS↓, *GutMicro↑, *IBI↑, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, *BioAv↑, *iNOS↓, *TNF-α↓, *IL6↓, *MDA↓, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *Catalase↑, *5HT↓, *TPH1↓, *MAPK↓, *ERK↓, *Inflam↓, cycD1/CCND1↓, CDK4↓, TumCCA↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, E-cadherin↑, N-cadherin↓, Vim↓,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2911- LT,    Luteolin targets MKK4 to attenuate particulate matter-induced MMP-1 and inflammation in human keratinocytes
- in-vitro, Nor, HaCaT
*MMP1↓, *COX2/PTGS2↓, *IL6↓, *AP-1↓, *NF-kB↓, *ROS↓, *p‑MKK4↑, *p‑JNK↓, *p‑p38↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE/β-secretase↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *Synergy↑,
3531- Lyco,    Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *ROS↓, *mtDam↓, *Bcl-2↑, *BAX↓, *Casp9↓, *Casp3↓, *Apoptosis↓, *RenoP↑, *lipid-P↓, *SOD↑, *GPx↑, *Inflam↓, *TNF-α↓, *IL6↓, *IL10↓,

Showing Research Papers: 251 to 300 of 474
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 474

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 7,   ARE↓, 1,   Catalase↓, 8,   Catalase↑, 5,   Ceru↓, 1,   GPx↓, 1,   GPx↑, 7,   GPx4↓, 1,   GSH↓, 17,   GSH↑, 6,   GSR↓, 2,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 2,   H2O2↑, 4,   HO-1↓, 3,   HO-1↑, 15,   Iron↑, 1,   Iron↝, 1,   Keap1↓, 1,   lipid-P↓, 2,   lipid-P↑, 4,   MDA↓, 4,   MDA↑, 4,   MPO↓, 4,   NQO1↓, 2,   NQO1↑, 4,   NRF2↓, 9,   NRF2↑, 18,   NRF2↝, 1,   p‑NRF2↓, 1,   Prx↓, 1,   Prx↑, 1,   Prx4↑, 1,   PrxII↓, 1,   ROS?, 1,   ROS↓, 21,   ROS↑, 102,   ROS⇅, 4,   ROS↝, 2,   i-ROS↑, 1,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 10,   SOD↑, 9,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   TAC↓, 1,   TBARS↑, 1,   Thiols↓, 1,   Trx1↓, 1,   Trx1↑, 1,   TrxR↓, 5,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 2,   CDC25↓, 6,   compIII↓, 1,   compIV↓, 1,   EGF↓, 1,   ETC↓, 3,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 11,   OCR↓, 1,   OXPHOS↓, 3,   mt-OXPHOS↓, 1,   PDH↑, 1,   PGC-1α↑, 1,   SDH↓, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 5,   ACC↓, 1,   ACC↑, 1,   ACLY↓, 1,   ALAT↓, 5,   ALAT↝, 1,   AMPK↓, 2,   AMPK↑, 10,   p‑AMPK↑, 1,   ATP↓, 8,   ATP↑, 1,   BHB↑, 1,   CAIX/CA9↑, 1,   ECAR↓, 1,   FASN↓, 3,   FDG↓, 1,   GlucoseCon↓, 6,   GlutMet↓, 1,   Glycolysis↓, 19,   GSK‐3β↓, 7,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   Histones↝, 1,   HK2↓, 10,   HMG-CoA↓, 1,   HMGCS2↑, 1,   lactateProd↓, 6,   LDHA↓, 4,   LDL↓, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 2,   PDK1 / PDPK1↓, 5,   PFK↓, 2,   PKM2↓, 9,   p‑PKM2↓, 1,   PLA2↓, 1,   p‑S6↓, 1,   SCD1↓, 2,   SIRT1↓, 5,   SIRT1↑, 5,   SIRT2↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 4,   Apoptosis?, 3,   Apoptosis↓, 5,   Apoptosis↑, 89,   Apoptosis↝, 1,   ASC↓, 2,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 2,   Bak↓, 1,   Bak↑, 3,   BAX↓, 2,   BAX↑, 51,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 9,   Bcl-2↓, 68,   Bcl-2↑, 1,   Bcl-2↝, 1,   Bcl-xL↓, 18,   Bcl-xL↝, 2,   BID↓, 1,   BID↑, 4,   BIM↑, 2,   BNIP3↑, 2,   BNIP3↝, 1,   Casp↓, 2,   Casp↑, 13,   Casp1↓, 3,   proCasp1↓, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp3↓, 3,   Casp3↑, 83,   Casp3↝, 1,   cl‑Casp3↑, 9,   pro‑Casp3↝, 1,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 18,   cl‑Casp8↑, 2,   Casp9↑, 45,   cl‑Casp9↑, 7,   proCasp9↓, 1,   cFLIP↓, 5,   Cyt‑c↑, 33,   Cyt‑c↝, 1,   Diablo↑, 3,   DR5↓, 1,   DR5↑, 9,   FADD↑, 2,   Fas↓, 2,   Fas↑, 13,   FasL↓, 1,   FasL↑, 5,   Ferroptosis↑, 3,   GranB/GZMB↝, 1,   GSDMD↑, 1,   HEY1↓, 1,   IAP1↓, 6,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 23,   Mcl-1↓, 10,   MDM2↓, 7,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↑, 1,   necrosis↑, 4,   NOXA↑, 1,   oncosis↑, 1,   P2X7↓, 1,   p38↓, 5,   p38↑, 6,   p‑p38↓, 2,   p‑p38↑, 1,   Perforin↝, 1,   PUMA↑, 2,   Pyro↑, 3,   survivin↓, 29,   survivin↝, 1,   TNFR 1↑, 1,   TRAIL↑, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 8,   TumCD∅, 1,   XIAP?, 1,   XIAP↓, 17,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 71,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 20,   Akt2↓, 1,   BRAF↝, 1,   CaMKII ↓, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 1,   cSrc↓, 2,   EGFR↓, 17,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 2,   ERK↓, 25,   ERK↑, 3,   ERK↝, 1,   p‑ERK↓, 8,   p‑ERK↑, 1,   FGFR1↓, 1,   HCAR2↑, 2,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↑, 1,   IGF-1R↓, 3,   IKKα↓, 5,   IKKα↑, 1,   p‑IKKα↓, 2,   IR↓, 1,   IκB↑, 1,   JAK↓, 4,   JAK1?, 1,   JAK1↓, 7,   JAK1↑, 1,   p‑JAK1↓, 1,   JAK2↓, 18,   p‑JAK2↓, 1,   JNK↓, 5,   JNK↑, 7,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 2,   MAPK↓, 18,   MAPK↑, 6,   MAPK↝, 3,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 1,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 44,   mTOR↝, 1,   p‑mTOR↓, 4,   P70S6K↓, 5,   p‑P70S6K↓, 1,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PAK↓, 1,   PI3K↓, 57,   PI3K↝, 2,   p‑PI3K↓, 2,   PI3K/Akt↓, 2,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 1,   PKA↓, 2,   PKCδ↓, 2,   PTEN↓, 1,   PTEN↑, 16,   PTEN↝, 2,   Raf↓, 2,   RAS↓, 6,   RAS↑, 1,   RCC1↓, 1,   p‑S6K↓, 1,   SHP1↑, 2,   Sp1/3/4↓, 7,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 4,   STAT3↓, 66,   STAT3↑, 1,   p‑STAT3↓, 15,   i-STAT3↓, 1,   STAT4↓, 3,   STAT5↓, 2,   STAT6↓, 1,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   SYK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 4,   ATF4↝, 1,   ChrMod↑, 1,   cJun↓, 3,   p‑cJun↓, 1,   cMyc↓, 27,   cMyc↑, 2,   DNMT1↓, 8,   DNMT3A↓, 2,   DNMT3B↓, 1,   DNMTs↓, 6,   EZH2↓, 4,   FOXM1↓, 3,   FOXO↑, 2,   FOXO1↓, 2,   FOXO1↑, 2,   FOXO3↓, 1,   FOXO3↑, 3,   FOXO3↝, 1,   p‑FOXO3↓, 1,   H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 3,   H4↓, 1,   ac‑H4↓, 1,   ac‑H4↑, 3,   HATs↓, 4,   HDAC↓, 16,   HDAC1↓, 4,   HDAC10↓, 1,   HDAC2↓, 5,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC6↓, 2,   miR-107↑, 1,   miR-124-3p↓, 1,   miR-134↑, 1,   miR-139-5p↑, 1,   miR-148a↑, 1,   miR-155↓, 2,   miR-21↓, 3,   miR-21↑, 1,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 3,   miR-422a↑, 1,   Myc↓, 1,   n-MYC↓, 1,   OCT4↓, 8,   other?, 1,   other↓, 2,   other↑, 2,   other↝, 6,   SOX2↓, 7,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   tumCV↓, 27,   tumCV∅, 1,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 10,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 3,   p‑eIF2α↑, 5,   ER Stress↑, 16,   GRP78/BiP↑, 6,   HSP27↓, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 9,   HSPs↑, 1,   NQO2↑, 1,   PERK↑, 2,   p‑PERK↑, 1,   UPR↑, 2,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↑, 7,   CTSB↓, 1,   CTSD↓, 1,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B-II↑, 1,   LC3II↓, 1,   LC3II↑, 4,   p62↓, 2,   TumAuto↑, 20,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↑, 1,   BRCA2↑, 1,   DFF45↑, 1,   DNAdam↓, 3,   DNAdam↑, 29,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC1↓, 2,   ERCC4/XPF↓, 1,   HR↓, 1,   hTERT/TERT↓, 8,   Ku70/XRCC6↓, 1,   p16↑, 3,   P53?, 1,   P53↓, 3,   P53↑, 42,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 1,   i-P53↓, 1,   p53 Wildtype↑, 1,   PARP↓, 2,   PARP↑, 10,   cl‑PARP↓, 1,   cl‑PARP↑, 25,   PARP1↑, 1,   PCNA↓, 24,   RAD51↓, 1,   SIRT6↓, 1,   Telomerase↓, 4,   TOP1↓, 1,   TOP2↓, 4,   TOP2↑, 1,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 7,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 14,   CDK2↑, 1,   CDK4↓, 23,   CDK4↑, 1,   CDK4/6↓, 1,   CDK6↓, 12,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   Chk2↓, 1,   p‑Chk2↑, 1,   Cyc↓, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 4,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 13,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 52,   cycD1/CCND1↑, 1,   cycD1/CCND1↝, 1,   CycD3↓, 1,   cycE/CCNE↓, 8,   cycE1↓, 2,   E2Fs↓, 5,   Ki-67↓, 16,   mitA↑, 1,   P21↓, 3,   P21↑, 23,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 10,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA↓, 1,   TumCCA↑, 85,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 5,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 3,   CD133↑, 1,   CD34↓, 1,   cFos↓, 4,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 25,   Diff↓, 2,   EP2↓, 1,   FGF↓, 3,   Gli↓, 1,   Gli1↓, 4,   HH↓, 2,   HH↝, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGFBP3↑, 2,   Ki-67↓, 16,   Let-7↑, 2,   LRP6↓, 1,   mTORC1↓, 1,   p‑mTORC1↓, 1,   Nanog↓, 5,   Nestin↓, 3,   NOTCH↓, 10,   NOTCH↑, 1,   NOTCH↝, 1,   NOTCH1↓, 13,   NOTCH1↑, 2,   NOTCH3↓, 2,   PTCH1↓, 1,   Shh↓, 9,   Smo↓, 1,   STAT1↓, 3,   TumCG?, 1,   TumCG↓, 37,   TumCG↑, 1,   TumCP↓, 69,   TumCP↑, 1,   TumCP∅, 1,   Wnt↓, 19,   Wnt↝, 2,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AP-1↓, 5,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 1,   BACH1↓, 1,   Ca+2↑, 9,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↓, 1,   CCN2/CTGF↓, 3,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 4,   E-cadherin↑, 26,   EMT↓, 41,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 3,   FAK↓, 7,   FAK↝, 1,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB1↑, 1,   LAMs↓, 2,   LEF1↓, 1,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MET↓, 1,   p‑MET↓, 1,   MMP-10↓, 2,   MMP1↓, 5,   MMP13↓, 2,   MMP16↓, 1,   MMP2↓, 61,   MMP2↝, 1,   MMP3↓, 4,   MMP7↓, 8,   MMP9↓, 67,   MMP9:TIMP1↓, 1,   MMPs↓, 17,   MTA1↓, 1,   N-cadherin↓, 20,   NCAM↑, 1,   PAK1↓, 1,   PDGF↓, 3,   PGF↓, 1,   Rac1↓, 1,   RECK↑, 2,   Rho↓, 2,   ROCK1↓, 3,   Slug?, 1,   Slug↓, 8,   Smad1↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 17,   TET1↑, 2,   TGF-β↓, 17,   TGF-β1↓, 1,   TIMP1↓, 2,   TIMP1↑, 6,   TIMP2↓, 3,   TIMP2↑, 7,   TRIB3↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI↓, 41,   TumCMig↓, 35,   TumMeta↓, 42,   TumMeta↑, 4,   Twist↓, 12,   Tyro3↓, 1,   uPA↓, 9,   uPA↝, 1,   uPAR↓, 4,   Vim↓, 23,   Vim↑, 1,   Zeb1↓, 7,   ZEB2↓, 1,   α-SMA↓, 4,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 24,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 46,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 2,   EGR4↓, 1,   HIF-1↓, 3,   Hif1a↓, 35,   NO↓, 10,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 74,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 13,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CellMemb↑, 1,   CLDN1↓, 2,   CLDN2↓, 1,   CX43/GJA1↓, 1,   EPR↑, 1,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   MMP↓, 42,   MMP↑, 1,   MMP↝, 1,   MPT↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 3,   CD44↓, 6,   CD47↓, 1,   CD8+↑, 4,   COX1↓, 2,   COX2/PTGS2↓, 82,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCL1↓, 1,   CXCL12↓, 3,   CXCR4↓, 15,   CXCR4↑, 1,   DCells↑, 2,   FOXP3↓, 1,   FOXP3↑, 1,   GM-CSF↓, 3,   HCAR2↑, 2,   HLA-I/II↑, 1,   HMGB1↓, 4,   ICAM-1↓, 5,   IFN-γ↓, 10,   IFN-γ↑, 4,   IL1↓, 13,   IL1↑, 2,   IL10↓, 11,   IL10↑, 4,   IL12↓, 6,   IL12↑, 1,   IL13↓, 1,   IL17↓, 3,   IL17↑, 1,   IL18↓, 4,   IL1α↓, 1,   IL1β↓, 51,   IL2↓, 6,   IL2↑, 6,   IL22↓, 2,   IL23↓, 1,   IL4↓, 3,   IL4↑, 3,   IL5↓, 2,   IL6?, 1,   IL6↓, 179,   IL6↑, 6,   IL6↝, 1,   IL8↓, 25,   IL8↑, 2,   Imm↑, 12,   Imm↝, 2,   INF-γ↓, 1,   Inflam↓, 50,   Inflam↑, 1,   IRAK4↓, 1,   LPS↓, 1,   M1↓, 1,   Macrophages↑, 1,   MCP1/CCL2↓, 7,   MDSCs↓, 1,   MIP2↓, 2,   MyD88↓, 1,   NF-kB↓, 109,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↓, 2,   NK cell↑, 6,   NK cell⇅, 1,   NLRP3↓, 9,   NLRP3↑, 2,   p50↓, 1,   p65↓, 3,   p‑p65↓, 2,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 2,   PD-L1↓, 7,   PGE1↓, 1,   PGE2↓, 19,   PSA↓, 4,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 1,   RANTES?, 1,   Resistin↓, 1,   T-Cell↑, 2,   TCF↓, 1,   Th1 response?, 1,   Th1 response↑, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↓, 9,   TLR4↑, 1,   TNF-α?, 1,   TNF-α↓, 84,   TNF-α↑, 6,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 8,   AR↝, 1,   ER-α36↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARα↓, 1,   PPARγ↓, 4,   PPARγ↑, 6,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 19,   BioAv↑, 21,   BioAv↝, 9,   BioEnh↑, 2,   ChemoSen↑, 76,   ChemoSen⇅, 1,   ChemoSen↝, 1,   CompStab↓, 2,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 1,   CYP1B1↑, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 7,   Dose↝, 35,   Dose∅, 5,   eff↓, 7,   eff↑, 30,   eff⇅, 1,   eff↝, 6,   eff∅, 2,   GSTA1↑, 1,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 5,   MDR1↓, 5,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   P450↓, 2,   RadioS↑, 24,   selectivity↑, 25,   Synergy↑, 58,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 5,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 8,   AR↝, 1,   AST↓, 3,   AST↝, 1,   BMD↑, 1,   BRAF↝, 1,   BRCA1↑, 1,   CA125↓, 1,   CA19-9↓, 1,   CEA↓, 4,   CRP↓, 9,   CYFRA21-1↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 17,   EGFR↑, 2,   EGFR↝, 1,   p‑EGFR↓, 2,   ERα/ESR1↓, 1,   EZH2↓, 4,   FOXM1↓, 3,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 8,   IL6?, 1,   IL6↓, 179,   IL6↑, 6,   IL6↝, 1,   LDH↓, 6,   LDH↑, 3,   i-LDH↓, 1,   Myc↓, 1,   NLR↓, 1,   NOS2↓, 3,   NSE↓, 1,   PD-L1↓, 7,   PSA↓, 4,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↑, 3,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 28,   antiNeop↑, 2,   AntiTum↑, 10,   AntiTum∅, 1,   Appetite↑, 2,   BowelM↑, 2,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 9,   CardioT↑, 1,   chemoP?, 1,   chemoP↑, 28,   chemoPv↑, 8,   ChemoSideEff↓, 2,   cognitive?, 1,   cognitive↑, 4,   hepatoP↓, 1,   hepatoP↑, 7,   K17↓, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   Obesity↓, 1,   OS↑, 15,   OS⇅, 1,   Pain↓, 5,   PFS↑, 1,   QoL↑, 9,   radioP↑, 13,   RenoP↑, 6,   Risk↓, 8,   Sleep↑, 2,   Strength↑, 2,   Symptoms∅, 1,   toxicity↓, 14,   toxicity↑, 1,   toxicity⇅, 1,   toxicity↝, 1,   TumVol↓, 16,   TumVol∅, 1,   TumW↓, 6,   TumW∅, 1,   Weight↓, 1,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   Bacteria↓, 2,   GutMicro↑, 8,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 3,  
Total Targets: 917

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 5,   antiOx↑, 113,   ARE↑, 3,   Bil↑, 1,   Catalase↑, 84,   DUOX1↓, 1,   Fenton↓, 3,   GCLC↑, 1,   GCLC↝, 1,   GCLM↑, 1,   GCLM↝, 1,   GPx↓, 2,   GPx↑, 54,   GPx1↑, 2,   GPx4↓, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 81,   GSR↓, 2,   GSR↑, 5,   GSSG↓, 2,   GSTs↓, 1,   GSTs↑, 17,   H2O2↓, 4,   HDL↓, 1,   HDL↑, 4,   HDL∅, 1,   HNE↓, 2,   HO-1?, 1,   HO-1↓, 3,   HO-1↑, 72,   HO-1↝, 1,   hyperG↝, 1,   Iron↓, 2,   Keap1↓, 4,   Keap1↑, 1,   Keap1↝, 2,   lipid-P↓, 59,   lipid-P↑, 2,   MDA↓, 81,   MPO↓, 15,   NFE2L2↓, 1,   NOX↓, 2,   NOX1↓, 1,   NOX2↓, 3,   NOX4↓, 6,   NQO1↑, 17,   NQO1↝, 1,   Nrf1↑, 3,   NRF2?, 1,   NRF2↓, 4,   NRF2↑, 102,   RNS↓, 6,   ROS?, 4,   ROS↓, 204,   ROS↑, 3,   ROS⇅, 1,   ROS↝, 1,   ROS∅, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   selenoP↑, 2,   SOD?, 1,   SOD↓, 1,   SOD↑, 114,   SOD1↑, 5,   SOD2↑, 4,   TAC↑, 14,   TBARS↓, 5,   Thiols↑, 1,   TOS↓, 1,   Trx↑, 1,   TrxR↑, 2,   UCPs↑, 1,   uricA↓, 3,   VitC↑, 2,   VitE↓, 1,   VitE↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   IronCh↓, 1,   IronCh↑, 7,   NCOA4↝, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   FIS1↓, 1,   Insulin↓, 2,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OXPHOS↑, 1,   PGC-1α↓, 2,   PGC-1α↑, 5,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 1,   SIRT3↑, 2,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 9,   ACADS/SCAD↑, 1,   ACC↑, 1,   ACSL4↓, 1,   adiP↑, 2,   ALAT↓, 30,   AMPK↓, 1,   AMPK↑, 19,   ATP↓, 1,   ATP↑, 10,   cAMP↑, 4,   CPT1A↑, 1,   CRM↑, 2,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FAM↑, 1,   FASN↓, 2,   glucose↓, 7,   GlucoseCon↑, 2,   GSK‐3β↓, 13,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   H2S↑, 2,   KeyT↝, 1,   LDL↓, 12,   lipidLev↓, 3,   LTC4↓, 1,   NAD↓, 1,   NAD↑, 2,   NADPH↓, 5,   NADPH↑, 3,   PKM2↓, 1,   SIRT1↑, 22,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 27,   ASC↓, 3,   BAD↓, 1,   BAX↓, 18,   BAX↑, 1,   Bax:Bcl2↓, 4,   Bcl-2↓, 5,   Bcl-2↑, 13,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 1,   Casp1↓, 5,   Casp12↓, 2,   Casp3↓, 34,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 4,   proCasp3↓, 1,   Casp6↓, 1,   Casp8↓, 2,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 14,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 6,   Cyt‑c∅, 1,   Ferroptosis↓, 3,   GranB/GZMB↓, 1,   iNOS↓, 67,   iNOS↑, 4,   MLKL↓, 1,   necrosis↓, 3,   p38↓, 10,   p‑p38↓, 3,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 11,   Akt↑, 14,   p‑Akt↓, 1,   p‑Akt↑, 4,   AKT1↓, 1,   AMPKα↑, 1,   CaMKII ↓, 1,   CREB↓, 1,   CREB↑, 4,   p‑CREB↑, 2,   EGFR↓, 2,   ERK↓, 15,   ERK↑, 3,   p‑ERK↓, 1,   HCAR2↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 3,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 2,   p‑JAK1↓, 1,   JAK2↓, 2,   JAK2↑, 2,   p‑JAK2↓, 1,   JNK↓, 12,   JNK↑, 1,   p‑JNK↓, 6,   MAPK?, 1,   MAPK↓, 22,   MAPK↑, 3,   p‑MAPK↓, 1,   p‑MKK4↑, 1,   mTOR↓, 6,   mTOR↑, 5,   mTOR↝, 1,   p‑mTOR↓, 2,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 9,   PI3K↑, 9,   PKA↑, 1,   PKCδ↓, 2,   PKCδ↑, 1,   PP2A↑, 2,   PTEN↓, 3,   PTEN↑, 1,   RIP1↓, 2,   STAT↓, 2,   STAT3↓, 7,   STAT3↑, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ARNT↑, 1,   ATF4↓, 4,   cJun↓, 2,   p‑cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   FOXO↑, 1,   FOXO3↑, 1,   HDAC↑, 1,   miR-23a-3p↓, 1,   miR-34a↓, 1,   other↓, 4,   other↑, 15,   other↝, 17,   other∅, 1,   RUNX2↑, 1,   SOX18↑, 1,   SOX9↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 2,   CHOP/DDIT3↓, 9,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 11,   GRP78/BiP↓, 8,   GRP78/BiP↑, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 6,   HSP90↓, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 2,   PERK↓, 2,   UPR↑, 1,   XBP-1↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 2,   MitoP↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 3,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   DNAdam↓, 7,   P53↓, 4,   PARP∅, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   PCNA↓, 1,   RAD51↓, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CD133↑, 1,   CEBPA↓, 1,   cFos↓, 1,   Choline↑, 2,   Diff↑, 1,   Diff↝, 1,   FGF↑, 1,   IGF-1↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   IGFBP3↑, 1,   Jun↑, 1,   Ki-67↓, 1,   MSCs↑, 1,   neuroG↑, 5,   p‑STAT1↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 3,   AntiAg↑, 6,   AP-1↓, 6,   ARG1/2↑, 2,   mt-ATPase↑, 1,   BACH1↓, 1,   Ca+2↓, 5,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 6,   COL1↓, 2,   COL1↑, 3,   COL2A1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibronectin↓, 1,   Fibronectin↑, 1,   ITGA5↓, 1,   ITGB1↓, 1,   LRP1↑, 1,   MMP-10↓, 1,   MMP-10↝, 1,   MMP1↓, 2,   MMP13↓, 3,   MMP2↓, 7,   MMP2↑, 1,   MMP3↓, 4,   MMP9↓, 14,   MUC1↑, 3,   Na+↑, 1,   NFAM1↑, 1,   NFAT↑, 2,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 2,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 5,   TGF-β↑, 7,   TGF-β1↓, 1,   TGF-β1↑, 2,   TIMP1↓, 1,   TIMP1↑, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 2,   uPA↑, 1,   Vim↓, 1,   Zeb1↓, 1,   α-SMA↓, 5,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 4,   angioG↝, 1,   E-sel↓, 2,   Endoglin↑, 1,   eNOS↓, 1,   p‑eNOS↑, 1,   Hif1a↓, 2,   Hif1a↑, 1,   NO↓, 51,   NO↑, 3,   REL↑, 1,   VCAM-1↓, 9,   VEGF↓, 5,   VEGF↑, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 25,   BBB↝, 4,   BBB∅, 2,   CLDN1↓, 1,   CLDN1↑, 4,   CLDN3↑, 1,   CLDN4↑, 1,   EPR↑, 1,   GastroP↑, 2,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 6,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 14,   MUC19↓, 1,   MUC2↓, 1,   MUC2↑, 1,   Na+↑, 1,   OCLN↓, 1,   OCLN↑, 5,   TJ↑, 4,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   VGSC↓, 1,   ZO-1↓, 2,   ZO-1↑, 9,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 3,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 88,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCc↑, 1,   CXCR4↓, 2,   FOXP3↑, 1,   HCAR2↑, 1,   HMGB1↓, 5,   ICAM-1↓, 10,   IFN-γ↓, 17,   IFN-γ↑, 4,   IL1?, 1,   IL1↓, 15,   IL10↓, 17,   IL10↑, 28,   IL12↓, 11,   IL12↑, 1,   IL17↓, 11,   IL17↑, 1,   IL18↓, 6,   IL1β↓, 141,   IL2↓, 9,   IL2↑, 3,   IL22↓, 1,   IL23↓, 2,   IL33↓, 2,   IL4↓, 5,   IL4↑, 7,   IL5↓, 2,   IL5↑, 1,   IL6?, 4,   IL6↓, 283,   IL6↑, 12,   IL8?, 1,   IL8↓, 33,   IL8↑, 1,   Imm↓, 1,   Imm↑, 11,   Imm↝, 1,   INF-γ↓, 2,   Inflam?, 1,   Inflam↓, 211,   Inflam↑, 2,   IP-10/CXCL-10↓, 3,   IRF3↓, 2,   LIF↑, 1,   LPS↓, 2,   LTA/TNF-β↑, 1,   M1↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 15,   MCP1/CCL2↑, 1,   MCP1/CCL2↝, 1,   MIP‑1α/CCL3?, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 3,   MyD88↓, 5,   NeuroI↓, 6,   NF-kB↓, 121,   NF-kB↑, 2,   p‑NF-kB↓, 1,   NK cell↑, 1,   NLRP3↓, 32,   NOD1↓, 1,   OSM↑, 1,   p65↓, 2,   p‑p65↓, 1,   PGD2↓, 1,   PGE1↓, 1,   PGE2↓, 38,   PGE2↑, 1,   PSA↓, 1,   RAGE↓, 1,   RANTES↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 4,   TLR4↓, 21,   TLR4↑, 1,   TNF-α?, 1,   TNF-α↓, 233,   TNF-α↑, 4,   Treg lymp↝, 1,   TRIF↓, 2,   β-HEX↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 4,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   5HT↑, 6,   Ach↑, 8,   AChE↓, 23,   ADAM10↑, 1,   BChE↓, 6,   BDNF↓, 2,   BDNF↑, 31,   BrainVol↑, 1,   ChAT↑, 4,   ChE↓, 1,   DA↑, 1,   EndoR↑, 1,   GABA↓, 1,   GABA↑, 1,   GABA↝, 1,   MAOA↓, 4,   MAOB↓, 1,   monoA↑, 1,   NGF↑, 6,   PSD95?, 1,   PSD95↑, 4,   RELN↑, 1,   SNAP25↑, 2,   SYN1↑, 1,   SYP↑, 1,   SYT1↑, 1,   TPH1↓, 1,   TrkB↑, 5,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APOE4↓, 1,   APP↓, 5,   cl‑APP↑, 1,   Aβ↓, 40,   Aβ42↓, 3,   BACE/β-secretase↓, 16,   PSEN1/PS1↓, 1,   PSEN1/PS1↑, 1,   tau↓, 12,   p‑tau↓, 15,   XO↓, 1,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 2,   ARNT↑, 1,   BNP↓, 1,   DHT↓, 1,   END↑, 1,   NR1H4↑, 1,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 8,   p‑PPARγ↓, 1,   testos↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 27,   BioAv↑, 54,   BioAv⇅, 1,   BioAv↝, 29,   BioEnh↑, 5,   ChemoSen↑, 2,   CompStab↑, 2,   CompStab↝, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 3,   Dose↓, 1,   Dose↑, 3,   Dose⇅, 2,   Dose↝, 52,   eff↓, 2,   eff↑, 36,   eff↝, 2,   GSTP1/GSTπ↑, 1,   Half-Life↓, 4,   Half-Life↑, 3,   Half-Life↝, 12,   MRP↓, 1,   P-gp/ABCB1↓, 2,   P450↓, 1,   P450↑, 1,   P450↝, 1,   selectivity↑, 2,   Synergy↑, 26,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 30,   ALB↑, 1,   ALP↓, 5,   anemia↓, 1,   AST↓, 31,   BG↓, 3,   Bil↑, 1,   BloodF↑, 2,   BMD↑, 6,   BP↓, 11,   BUN?, 1,   BUN↓, 5,   colonLen↑, 1,   creat↓, 13,   CRP↓, 13,   EGFR↓, 2,   Ferritin↓, 1,   Hcy/homoC↓, 2,   Hcy/homoC↝, 1,   HemoG↑, 2,   hs-CRP↓, 1,   IL6?, 4,   IL6↓, 283,   IL6↑, 12,   KeyT↝, 1,   LDH↓, 11,   LDH↑, 1,   NOS2↓, 1,   PSA↓, 1,   RAGE↓, 1,   RBC↑, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 3,   TMAO↓, 1,   Urea↓, 3,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 6,   antiAll?, 1,   antiAll↑, 17,   AntiArt↑, 7,   AntiCan↑, 20,   antiCG↑, 2,   antiD↓, 1,   AntiDiabetic↑, 24,   antiPs↑, 4,   AntiTum↑, 1,   cardioP?, 1,   cardioP↑, 58,   chemoP↑, 12,   chemoPv↑, 3,   cognitive↓, 2,   cognitive↑, 59,   cognitive↝, 1,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 1,   hepatoP↑, 62,   Learn↑, 6,   memory↑, 40,   Mood↑, 2,   motorD↓, 1,   motorD↑, 7,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 129,   NP/CIPN↓, 1,   Obesity↓, 14,   OS↑, 6,   Pain↓, 11,   QoL↑, 2,   radioP↑, 7,   RenoP↓, 1,   RenoP↑, 27,   Risk↓, 3,   Sleep↑, 4,   Strength↑, 4,   Stress↓, 1,   Stroke↓, 16,   toxicity↓, 23,   toxicity↑, 1,   toxicity↝, 7,   toxicity∅, 4,   Weight↓, 1,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 12,   AntiFungal↓, 1,   AntiFungal↑, 6,   AntiP↑, 1,   AntiViral↑, 9,   Bacteria↓, 15,   Diar↓, 2,   GutMicro↑, 34,   Inf↓, 1,   Sepsis↓, 10,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↑, 1,   Ingr↝, 10,  
Total Targets: 702

Scientific Paper Hit Count for: IL6, Interleukin-6
19 Hydrogen Gas
16 Curcumin
15 Quercetin
13 Lycopene
13 Sulforaphane (mainly Broccoli)
11 Magnetic Fields
9 EGCG (Epigallocatechin Gallate)
9 Luteolin
8 Propolis -bee glue
8 Resveratrol
8 Silymarin (Milk Thistle) silibinin
8 Shikonin
8 Thymoquinone
7 Baicalein
7 Beta-Caryophyllene
7 Celastrol
7 isoorientin
7 Urolithin
6 Silver-NanoParticles
6 Artemisinin
6 Melatonin
6 Cisplatin
6 Berberine
6 Boron
6 Morin
6 Rosmarinic acid
5 Alpha-Lipoic-Acid
5 Ashwagandha(Withaferin A)
5 Crocetin
5 Eugenol
5 Honokiol
5 Hyperoside
5 Isoliquiritigenin
4 Apigenin (mainly Parsley)
4 Isovitexin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Chemotherapy
4 Chlorogenic acid
4 Piperine
4 Ellagic acid
4 Emodin
4 Folic Acid, Vit B9
4 Fisetin
4 lambertianic acid
4 Matrine
4 Piperlongumine
4 Vitamin C (Ascorbic Acid)
3 Açaí, Euterpe oleracea
3 Allicin (mainly Garlic)
3 Butyrate
3 Caffeic acid
3 Ferulic acid
3 Inositol
3 Kaempferol
3 Lactoferrin/Talactoferrin
3 Linalool
3 5-fluorouracil
3 Magnolol
3 Magnetic Field Rotating
3 Mushroom Lion’s Mane, Hericium erinaceus
3 Pterostilbene
3 Selenite (Sodium)
2 Auranofin
2 Astragalus
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Anethole/trans-Anethole
2 Ascorbyl Palmitate
2 Astaxanthin
2 Aloe anthraquinones
2 beta-glucans
2 Baicalin
2 Betulinic acid
2 Benzyl isothiocyanate
2 Phenethyl isothiocyanate
2 Allyl isothiocyanate
2 borneol
2 Selenium
2 Black Rice, Oryza sativa
2 Capsaicin
2 Carvacrol
2 Chrysin
2 Coenzyme Q10
2 Ursolic acid
2 eicosapentaenoic acid
2 diet Fermented Foods
2 Dandelion Root
2 Radiotherapy/Radiation
2 Vitamin B12
2 Formononetin
2 Flaxseed/Linseed
2 Gallic acid
2 Paclitaxel/Taxol
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 Licochalcone A
2 Licorice
2 Moringa oleifera
2 Methylsulfonylmethane
2 Nimbolide
2 Rutin
2 Selenium NanoParticles
1 1,8-Cineole
1 2-DeoxyGlucose
1 Annona atemoya Seed Extract
1 alpha Linolenic acid
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Atorvastatin
1 immunotherapy
1 Berbamine
1 Biochanin A
1 xanthohumol
1 Isothiocyanates
1 Bacopa monnieri
1 Beetroot
1 Bruteridin(bergamot juice)
1 buckwheat sprouts
1 Carnosine
1 Camu camu
1 Centella asiatica / Gotu kola → asiaticoside
1 Chyawanprash
1 Cinnamon
1 Cranberry
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Oxygen, Hyperbaric
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Docosahexaenoic Acid
1 diet Short Term Fasting
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Ginkgo biloba-EGb 761
1 Tetrahydroxystilbene glucoside
1 Electrical Pulses
1 Exercise
1 Sesame seeds and Oil
1 Flaxseed Oil
1 Gamma-aminobutyric acid
1 Galloflavin
1 Gambogic Acid
1 Garcinol
1 Ginkgo biloba
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 HydroxyCitric Acid
1 Orlistat
1 Hops (Humulus lupulus)
1 phytic acid, Inositol hexakisphosphate
1 capecitabine
1 isoquercitrin
1 Ivermectin
1 doxorubicin
1 Juglone
1 Potassium
1 L-Theanine
1 SDG/lignans
1 Mung Bean Sprouts
1 mebendazole
1 gefitinib, erlotinib
1 methylseleninic acid
1 Moringin
1 Mangiferin
1 Methylene blue
1 Mushroom Maitake
1 Naringin
1 Niclosamide (Niclocide)
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 Phycocyanin
1 probiotics
1 Bifidobacterium
1 Phosphatidylserine
1 Perilla
1 Rauwolfia serpentina/Indian Snakeroot
1 Docetaxel
1 Salvia miltiorrhiza
1 Spirulina(Arthrospira/Limnospira)
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin B3,Niacin
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:158  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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