Synergy Cancer Research Results

Synergy, Synergy: Click to Expand ⟱
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Synergy — Interaction in which two or more agents, treatments, or biological interventions produce a combined effect greater than would be expected from their individual effects. In pharmacology and cancer research, synergy commonly refers to enhanced therapeutic efficacy when a compound is combined with chemotherapy, radiation, targeted therapy, or another bioactive agent.

Typical modulation in cancer: ↑ synergy is generally favorable when it increases tumor-cell killing, suppresses proliferation, enhances apoptosis or ferroptosis, or improves sensitivity to anticancer therapy. Synergy should be distinguished from simple additive effects and ideally supported by quantitative combination analysis such as combination index, Bliss independence, Loewe additivity, or related methods.

Typical modulation in Alzheimer’s disease: Context-dependent. Synergy may describe enhanced neuroprotective, anti-inflammatory, antioxidant, or cognitive effects produced by combinations of compounds or treatments, but it is not a disease-specific molecular pathway.
Scientific Papers found: Click to Expand⟱
7643- Ins,  IP6,    Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical stud
- Trial, BC, NA
RBC↑, QoL↑, Synergy↑, Imm↑, ChemoSen↑, chemoP↑, Dose↝,
7631- Ins,  IP6,    Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
- Review, Var, NA
other↑, p‑pRB↓, TumCCA↑, PI3K↓, Akt↓, ERK↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, PSEN1/PS1↓, EMT↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, N-cadherin↓, Snail↓, E-cadherin↑, fascin↓, Cofilin↓, MMPs↓, ROCK1↓, Dose↝, other↝, selectivity↑, *ROS↓, *lipid-P↓, ROS↑, NK cell↑, Imm↑, TNF-α↓, ChemoSen↑, Dose↑, toxicity↓, QoL↑, chemoP↑, OS↑, Dose↝, Insulin↓, glucose↝, lipoGen↓, Synergy↑,
7672- iod,    Adjuvant Effect of Molecular Iodine in Conventional Chemotherapy for Breast Cancer. Randomized Pilot Study
- Trial, BC, NA
Dose↝, OS↑, TumCI↓, Apoptosis↑, EstroRS/ERS↑, Synergy↑, *cardioP↑, *antiOx↑, *Inflam↓,
7653- IP,    Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel
- in-vivo, Var, NA
GutMicro↑, T-Cell↑, AntiTum↑, Synergy↑, TumCG↓,
7722- IP6,    Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic
- Review, Var, NA
Synergy↑, TumCP↓, Diff↑, TumCCA↑, Imm↑, antiOx↑, BioAv↑, toxicity↓, ChemoSen↑, TumMeta↓, QoL↑,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, Synergy↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7696- IP6,  Ins,    The Combination of Inositol Hexaphosphate and Inositol Inhibits Metastasis of Colorectal Cancer Cells by Upregulating Claudin 7
- vitro+vivo, Colon, SW48 - in-vitro, Colon, SW-620
AntiCan↑, CLDN7↑, EMT↓, E-cadherin↑, N-cadherin↓, Synergy↑, TumCG↓,
7861- isoO,    Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *GSK‐3β↓, *TNF-α↓, *IL6↓, *IL1β↓, *p‑GSK‐3β↑, *Synergy↑, *COX2/PTGS2↓, *ERK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *OCLN↑, *ZO-1↑, *BBB↝,
7835- ISQ,  QC,    Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves
- in-vitro, AD, HT22
*Apoptosis↓, *ROS↓, *SOD2↑, *Ca+2↓, *mtDam↓, *NRF2↑, *HO-1↑, *other↑, *AIF↓, *LC3‑Ⅱ/LC3‑Ⅰ↓, *Synergy↑,
7994- itraC,    From fungus fighter to cancer slayer: itraconazole as a multifaceted candidate for drug-resistant prostate cancer
- Review, Pca, NA
HH↓, Gli1↓, TumCP↓, TumCI↓, Synergy↑,
8033- IVM,  dietMet,  rMETase,    Direct comparison of efficacy of combining ivermectin versus five first-line chemotherapy drugs with recombinant methioninase against colon-cancer cells
- in-vitro, CRC, HCT116
eff↑, ChemoSen↑, Synergy↑, selectivity↑, Synergy↑, TumCCA↑,
8029- IVM,    Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?
- Review, Var, NA
TumCP↓, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓, Akt↓, mTOR↓, BBB∅, ROS↑, MMP↓, Casp3↓, Casp9↑, TumCCA↑, P53↑, cMyc↓, MMP9↓, HSP27↓, ICD↑, Synergy↑, *AntiP↑,
8026- IVM,  immuno,    Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer
- vitro+vivo, BC, 4T1
ICD↑, Imm↝, Synergy↑, TumVol↓,
7962- JG,    Peptidyl prolyl isomerase, Pin1 is a potential target for enhancing the therapeutic efficacy of etoposide
- in-vitro, Var, NA
Synergy↑, Pin1↓, *DNAdam↓,
8006- JG,  VitC,    Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCP↓, ROS↑, antiOx⇅, Bcl-2↓, survivin↓, BAX↑, Trx2↓, Synergy↑,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
8068- KAE,  TRAIL/rTRAIL,    Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis
- in-vitro, Colon, NA
Synergy↑, DR4↑, DR5↑,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8174- Lap,    Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases
EGFR↓, HER2/EBBR2↓, BioAv↝, Synergy↑, Dose↝,
8341- LDN,    Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy
- Review, Var, NA
OGFr↑, TumCP↓, TumCCA↑, Apoptosis↑, toxicity↝, Half-Life↝, *FasL↓, *Fas↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, survivin↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, ChemoSen↑, chemoP↑, Synergy↑, QoL∅,
8277- LE,    Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights
- Review, Var, NA
*antiOx↑, *AntiTum↑, HMGB1↓, COX2/PTGS2↓, PGE2↓, TumCP↓, TumCCA↑, Synergy↑, MMP↓, p‑P53↑, BAX↑, cl‑PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, ROS↑, TumAuto↑, MMP9↓, TumMeta↓, PI3K↓, Akt↓, eff↑, *chemoP↑, *NRF2↑, *NF-kB↓,
1790- LEC,  DHA,    Dietary Crude Lecithin Increases Systemic Availability of Dietary Docosahexaenoic Acid with Combined Intake in Rats
- in-vivo, Nor, NA
*Synergy↑, other↑,
1795- LEC,  Chit,    Self-assembled lecithin-chitosan nanoparticles improve the oral bioavailability and alter the pharmacokinetics of raloxifene
- in-vivo, Nor, NA
Synergy↑, BioAv↑,
6464- LIN,  1,8-Cin,    Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
- in-vitro, NSCLC, A549 - in-vitro, Nor, WI38
TumCP↓, TumCCA↑, selectivity↑, ROS↑, MMP↓, eff↓, TumCMig↓, Synergy↑,
8386- LT,    Luteolin induces apoptosis in Philadelphia chromosome-positive acute lymphoblastic leukemia cell by regulating the PI3K/AKT signaling pathway
- in-vitro, ALL, SUP-B15
tumCV↓, ROS↑, MMP↓, ATP↓, p‑PI3K↓, p‑Akt↓, p‑STAT3↓, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, TumCP↓, eff↓, ChemoSen↑, FAK↓, Synergy↑, BioAv↓, BioAv↑,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE/β-secretase↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *Synergy↑,
3982- Lut,  Zeax,    Nutritional Intervention to Prevent Alzheimer's Disease: Potential Benefits of Xanthophyll Carotenoids and Omega-3 Fatty Acids Combined
- Trial, AD, NA
*memory↑, *Synergy↑, *Mood↑,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2/PTGS2↓, *LDL↓, *Synergy↑, *ER Stress↓, *BioAv↑, *Synergy↑, *MMPs↓, *COX2/PTGS2↓, *RAGE↓,
3285- Lyco,    Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study
- in-vitro, Nor, NA
*AntiAg↑, *Synergy↑,
1715- Lyco,    Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence
- Review, Var, NA
antiOx↑, ROS↑, ChemoSen↑, selectivity↑, eff↓, Casp3↑, Casp7↑, Casp9↑, P53↑, BAX↑, DNAdam↑, mtDam↑, Synergy↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, Synergy↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4798- Lyco,    Enhancing Anticancer Treatment Efficacy With Lycopene: A Comprehensive Review of Clinical and Preclinical Evidence
- Review, Var, NA
AntiCan↑, ChemoSen↑, eff↑, Synergy↑,
4792- Lyco,    A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy
- Review, Var, NA
*AntiCan↑, *antiOx↑, Inflam↓, Wnt↓, β-catenin/ZEB1↓, *ROS↓, BioAv↑, ROS↓, Risk↓, PGE2↓, COX2/PTGS2↓, p‑ERK↓, P21↑, MMP7↓, MMP9↓, ChemoSen↑, Synergy↑,
8414- Lyco,    Exploring the Therapeutic Potential of Lycopene: Mechanisms, Biological Activities, and Health Benefits
- Review, Var, NA - Review, AD, NA
*ROS↓, *Inflam↓, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiArt↑, *Obesity↓, *Wound Healing↑, *BioAv↑, *GSTs↑, *Trx1↑, *SOD↑, *Catalase↑, *ALAT↓, *LDH↓, *AST↓, *MDA↓, *cognitive↑, *memory↑, *NeuroI↓, *Aβ↓, *LRP1↑, *RAGE↓, *NRF2↑, *HO-1↑, tumCV?, Bax:Bcl2↑, DNAdam↑, Apoptosis↑, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, ROS↓, TumCCA↑, Akt↓, *Synergy↑, *MDA↓, *NF-kB↓, *TGF-β↓, *Casp3↓, *Catalase↑, *GSH↑, *Bcl-2↑, *IL10↑, *MUC1↑, *IBI↑, *RenoP↑, *ChemoSen↑, *Synergy↑, *Synergy↑, *BMD↑,
8413- Lyco,  VitE,    Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation
- in-vivo, AD, NA
*memory↑, *MDA↓, *GPx↑, *tau↓, *Synergy↑,
8415- Lyco,  CUR,    Combination of Lycopene and Curcumin Synergistically Alleviates Testosterone-Propionate-Induced Benign Prostatic Hyperplasia in Sprague Dawley Rats via Modulating Inflammation and Proliferation
- in-vivo, BPH, NA
*Dose↝, *Synergy↑, *Ki-67↓, *testos↓, *DHT↓, *PSA↓, *IL1β↓, *IL6↓, *AKT1↓, *TNF-α↓, *EGFR↓, *STAT3↓, *COX2/PTGS2↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, Synergy↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, Synergy↑, survivin↓, XIAP↓, Synergy↑,
8538- Matr,    Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling
- in-vitro, BC, MDA-MB-231 - ex-vivo, BC, MDA-MB-231
TumCP↓, Synergy↑, Apoptosis?, Bax:Bcl2↑, TumCI↓, MMP9↓, MMP2↓, Akt↓, NF-kB↓, VEGFR1↓, BioAv↝,
8527- Matr,    Matrine Promotes Human Myeloid Leukemia Cells Apoptosis Through Warburg Effect Mediated by Hexokinase 2
- in-vitro, AML, K562
TumCP↓, Apoptosis↑, Warburg↓, HK2↓, Synergy↑, Glycolysis↓,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
1777- MEL,    Melatonin as an antioxidant: under promises but over delivers
- Review, NA, NA
*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, Synergy↑,
6418- MEL,  RES,    Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1-PGC-1α pathway activation
- in-vivo, AD, NA
*neuroP↑, *DRP1/DNM1L↓, *FIS1↓, *ROS↓, *MMP↑, *SIRT1↑, *PGC-1α↑, *Synergy↑,
1043- MET,  immuno,    Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy
- in-vitro, NA, NA
Synergy↑, PD-L1↓, Ki-67↑, TIM-3↑, L-sel↑,
2379- MET,    Down‐regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer
- in-vitro, Bladder, T24/HTB-9 - in-vitro, BC, UMUC3
PKM2↓, p‑STAT3↓, TumCG↓, Synergy↑, chemoP↑, AMPK↑,
2387- MET,  GEM,    Metformin Increases the Response of Cholangiocarcinoma Cells to Gemcitabine by Suppressing Pyruvate Kinase M2 to Activate Mitochondrial Apoptosis
- in-vitro, CCA, HCC9810
Synergy↑, tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, PKM2↓, PDHB↓,

Showing Research Papers: 251 to 300 of 415
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 415

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

APE1/APEX1↓, 1,   AURKB↓, 1,   CBR1↓, 1,   CD47↓, 1,   CLDN7↑, 1,   compV↓, 1,   ERCC3↑, 1,   H3K9↓, 3,   IRes↓, 1,   KAI1/CD82↑, 1,   miR-107↑, 1,   miR-124-3p↓, 1,   miR-224↓, 1,   miR-375↑, 1,   miR-422a↑, 1,   MMP16↓, 1,   MYCN↑, 1,   NA↑, 2,   OGFr↑, 1,   OLIG2↓, 1,   ORR↑, 1,   PFS↓, 1,   PFS↑, 1,   PLA2↓, 1,   PSEN1/PS1↓, 1,   PTN↓, 1,   RBC↑, 1,   SUV39H↓, 3,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   antiOx⇅, 1,   ATF3↑, 1,   Catalase↓, 3,   Catalase↑, 2,   compI↓, 2,   CYP1A1↑, 1,   Fenton↑, 5,   Ferroptosis↓, 1,   Ferroptosis↑, 14,   frataxin↑, 1,   GPx↓, 3,   GPx↑, 2,   GPx4↓, 4,   GPx4↑, 1,   GSH↓, 20,   GSH↑, 1,   GSH↝, 1,   GSR↑, 1,   GSSG↑, 1,   GSTP1/GSTπ↓, 2,   GSTs↓, 1,   GSTZ1↓, 1,   H2O2↑, 5,   HK1↓, 1,   HO-1↓, 3,   HO-1↑, 10,   hyperG↓, 1,   ICD↑, 2,   Iron↑, 5,   i-Iron↑, 1,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 10,   MDA↓, 1,   MDA↑, 4,   Mets↑, 1,   MFN2↑, 1,   NQO1↑, 3,   NRF2↓, 10,   NRF2↑, 13,   OXPHOS↓, 6,   OXPHOS↑, 4,   OXPHOS↝, 2,   PARK2↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROS?, 2,   ROS↓, 18,   ROS↑, 174,   ROS⇅, 3,   i-ROS↑, 1,   mt-ROS↑, 3,   SIRT3↓, 1,   SIRT3↑, 2,   SOD↓, 4,   SOD↑, 3,   Trx↓, 3,   Trx1↓, 1,   Trx2↓, 1,   TrxR↓, 4,   TrxR1?, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 4,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   KLF5↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   AIF↑, 2,   ATP↓, 14,   ATP↑, 1,   mt-ATP↓, 1,   BCR-ABL↓, 1,   CDC2↓, 3,   CDC25↓, 1,   compIII↓, 1,   EGF↓, 2,   ETC↓, 1,   ETC↑, 1,   ETC↝, 1,   FGFR1↓, 1,   Insulin↓, 2,   MEK↓, 5,   mitResp↓, 1,   mitResp↑, 3,   MMP↓, 56,   MMP↑, 3,   Mortalin↓, 1,   MPT↑, 4,   mtDam↑, 10,   OCR↓, 2,   OCR↑, 2,   PGC-1α↑, 1,   PINK1↑, 1,   Raf↓, 2,   c-Raf↓, 1,   SDH↓, 1,   XIAP↓, 12,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 3,   ACLY↓, 4,   p‑ACLY↓, 1,   ACSL4↑, 2,   adiP↑, 1,   ALAT↓, 4,   ALAT↑, 1,   AMP↑, 1,   AMPK↑, 17,   ATG7↑, 2,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 2,   cMyc↓, 23,   CPT1A↓, 1,   CYP3A4↓, 1,   ECAR↓, 1,   FASN↓, 4,   FASN↑, 1,   FGF21↓, 1,   glucoNG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 6,   GlucoseCon↑, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 33,   Glycolysis↑, 1,   Histones↝, 1,   HK2↓, 16,   HMG-CoA↓, 9,   KeyT↑, 1,   lactateProd↓, 11,   lactateProd↑, 1,   LDH↓, 10,   p‑LDH↓, 1,   LDHA↓, 6,   LDL↓, 3,   lipoGen↓, 2,   NADH:NAD↓, 1,   NADPH↓, 4,   NADPH↑, 2,   PDH↓, 1,   PDH↑, 5,   p‑PDH↑, 1,   PDHB↓, 1,   PDK1 / PDPK1↓, 8,   PDK3↑, 1,   PDKs↓, 10,   PFK↓, 2,   PFK2?, 1,   PFKFB2↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 11,   PKM2↑, 1,   POLD1↓, 1,   PPARα↓, 2,   PPARγ↓, 1,   PPARγ↑, 3,   p‑S6K↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 4,   SIRT2↓, 2,   SREBP2↓, 2,   STK11/LKB1↑, 1,   TCA↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 10,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 119,   ASK1↑, 1,   BAD↑, 4,   BAD↝, 1,   Bak↑, 4,   BAX↓, 3,   BAX↑, 59,   BAX↝, 2,   Bax:Bcl2↑, 16,   Bcl-2↓, 67,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 15,   Bcl-xL↑, 1,   BID↑, 1,   BIM↑, 6,   Casp↑, 18,   Casp1↑, 1,   Casp12?, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 3,   Casp3↑, 77,   cl‑Casp3↑, 11,   cl‑Casp3⇅, 1,   proCasp3↑, 2,   pro‑Casp3↑, 1,   Casp7↑, 6,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 8,   cl‑Casp8↑, 2,   proCasp8↑, 2,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 42,   cl‑Casp9↑, 6,   proCasp9↑, 2,   cFLIP↓, 2,   Chk2↓, 1,   CK2↓, 4,   Cupro↑, 1,   Cyt‑c↑, 35,   Diablo↑, 4,   DR4↑, 5,   DR5↑, 14,   FADD↑, 2,   Fas↑, 10,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 14,   GSDME-N↑, 1,   HEY1↓, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 10,   IAP1↓, 3,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 6,   iNOS↑, 2,   JNK↓, 3,   JNK↑, 9,   p‑JNK↓, 3,   p‑JNK↑, 1,   MAPK↓, 8,   MAPK↑, 5,   MAPK↝, 1,   p‑MAPK↓, 1,   Mcl-1↓, 16,   Mcl-1↑, 1,   MDM2↓, 3,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↑, 2,   Myc↓, 4,   Myc↑, 1,   Necroptosis↑, 3,   necrosis↑, 2,   NOXA↑, 1,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 7,   p38↓, 2,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 2,   Paraptosis↑, 2,   Proteasome?, 1,   Proteasome↓, 3,   PUMA↑, 3,   Pyro↑, 3,   survivin↓, 24,   Telomerase↓, 6,   TRAIL↑, 1,   TRPV1↑, 1,   TumCD↓, 2,   TumCD↑, 18,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 67,   Akt↑, 11,   p‑Akt↓, 17,   Akt2↓, 1,   AMPKα↑, 1,   cSrc↓, 1,   EF-1α↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 7,   miR-25-5p↓, 1,   p70S6↓, 1,   SOX9?, 1,   SOX9↓, 1,   Sp1/3/4↓, 7,   TRPV2↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↝, 1,   cJun↓, 7,   cJun↑, 3,   EZH2↓, 3,   H3↑, 2,   ac‑H3↑, 3,   H3K4↓, 1,   H4↑, 1,   ac‑H4↑, 3,   HATs↓, 3,   HATs↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   other↓, 5,   other↑, 9,   other↝, 11,   PCAF↓, 1,   PhotoS↑, 3,   pRB↓, 1,   p‑pRB↓, 2,   sonoS↑, 2,   tumCV?, 1,   tumCV↓, 31,   tumCV↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 9,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↑, 2,   ER Stress↑, 34,   GRP78/BiP↓, 2,   GRP78/BiP↑, 9,   GRP78/BiP↝, 1,   GRP94↑, 1,   HSP27↓, 4,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 4,   HSP72↑, 1,   HSP90↓, 9,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 3,   PERK↑, 4,   UPR↑, 9,   XBP-1↓, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 2,   autoF↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   p‑Beclin-1/ATG6↑, 1,   BNIP3↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 9,   LC3s↓, 1,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 6,   SESN2↑, 1,   TumAuto↑, 32,   TumAuto⇅, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   DNA-PK↑, 2,   DNAdam↑, 38,   DNArepair↓, 2,   DNArepair↑, 1,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMT3B↓, 1,   DNMTs↓, 5,   m-FAM72A↓, 1,   GADD45A↑, 1,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 35,   p‑P53↓, 1,   p‑P53↑, 3,   PARP↑, 9,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 35,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 13,   SIRT6↓, 1,   TP53↓, 2,   TP53↑, 3,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK2↓, 20,   CDK4↓, 27,   CDK4↑, 3,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   CycB/CCNB1↓, 12,   cycD1/CCND1↓, 41,   CycD3↓, 3,   cycE/CCNE↓, 13,   cycE1↓, 1,   E2Fs↓, 2,   mitA↑, 1,   P21?, 2,   P21↓, 3,   P21↑, 21,   RB1↑, 1,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 4,   TumCCA↑, 87,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 5,   ALDH1A1↓, 1,   CD133↓, 3,   CD133↑, 1,   CD24↓, 1,   CD44↓, 7,   cFos↓, 7,   cMYB↓, 2,   CSCs↓, 35,   CSCsMark↓, 1,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   Diff↓, 3,   Diff↑, 6,   EMT↓, 47,   EMT↑, 2,   ERK↓, 13,   ERK↑, 5,   ERK↝, 1,   p‑ERK↓, 11,   FGF↓, 1,   FOXM1↓, 3,   FOXO↑, 1,   FOXO1↓, 2,   FOXO3↓, 1,   FOXO3↑, 7,   FOXO4↓, 1,   FOXO4↑, 1,   Gli↓, 1,   Gli1↓, 4,   GSK‐3β↓, 4,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   HDAC↓, 19,   HDAC1↓, 2,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC8↓, 1,   HH↓, 6,   HMGCR↓, 1,   HMGCR↑, 1,   HMGCR⇅, 1,   HMTs↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGF-1R↓, 3,   IGF-1R↑, 1,   IGFBP1↑, 2,   IGFBP3↑, 1,   KLF4↓, 1,   Let-7↑, 2,   LRP6↓, 1,   p‑MAP2K1/MEK1↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   mTOR↓, 41,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   mTORC1↓, 4,   p‑mTORC1↓, 1,   mTORC2↓, 1,   n-MYC↓, 2,   Nanog↓, 9,   Nestin↓, 3,   NOTCH↓, 6,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↑, 4,   NOTCH3↓, 3,   OCT4↓, 7,   p300↓, 1,   P70S6K↓, 3,   p‑P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 51,   PI3K↑, 4,   p‑PI3K↓, 3,   PTCH1↓, 2,   PTCH2↓, 1,   PTEN↑, 11,   RAS↓, 6,   SAL↑, 1,   Shh↓, 3,   SHP1↑, 2,   Smo↓, 1,   SOX2↓, 4,   Src↓, 1,   STAT↓, 2,   STAT3↓, 41,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 4,   STAT4↓, 1,   STAT5↓, 1,   STAT6↓, 2,   TCF↓, 1,   TCF↑, 1,   TCF-4↓, 1,   TOP1↓, 5,   TOP2↓, 2,   TOP2↑, 1,   TRPM7↓, 1,   TumCG↓, 71,   TumCG↑, 2,   tyrosinase↓, 1,   Wnt↓, 22,   Wnt↑, 2,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 5,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 5,   AXL↓, 1,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 13,   CAFs/TAFs↓, 1,   cal2↑, 1,   CC(CDKs/cyclins)↓, 1,   CD11b↑, 2,   CDKN1C/p57↑, 1,   CLDN1↓, 3,   CLDN2↓, 1,   CLDN2↑, 1,   Cofilin↓, 1,   CXCL12↓, 2,   E-cadherin↓, 4,   E-cadherin↑, 25,   ER-α36↓, 2,   FAK↓, 5,   p‑FAK↓, 2,   fascin↓, 2,   Fibronectin↓, 5,   GLI2↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   ITGB4↓, 1,   Ki-67↓, 17,   Ki-67↑, 1,   KLF2↓, 1,   KRAS↓, 2,   L-sel↑, 1,   LAMs↓, 2,   MALAT1↓, 3,   MET↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-29b↓, 1,   miR-340↓, 1,   miR-384↑, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP13↓, 1,   MMP15↓, 1,   MMP2↓, 40,   MMP2↑, 1,   MMP3↓, 2,   MMP7↓, 6,   MMP9↓, 49,   MMP9↑, 2,   MMPs↓, 19,   MUC1↑, 1,   MUC4↓, 1,   N-cadherin↓, 16,   PAK1↓, 1,   PDGF↓, 2,   PKA↓, 1,   PKA↑, 1,   PKCδ↓, 5,   RECK↑, 1,   Rho↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   ROCK1↓, 3,   Slug↓, 9,   Smad1↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 13,   SOX4↓, 2,   STAC2↓, 1,   TET1↑, 4,   TGF-β↓, 11,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 4,   Treg lymp↓, 2,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 51,   TumCMig↓, 36,   TumCMig↑, 1,   TumCP?, 1,   TumCP↓, 69,   TumCP↑, 2,   TumMeta↓, 36,   TumMeta↑, 2,   Twist↓, 7,   uPA↓, 9,   uPAR↓, 1,   VEGFR1↓, 1,   Vim?, 1,   Vim↓, 19,   Zeb1↓, 10,   Zeb1↑, 1,   ZEB2↓, 2,   ZO-1↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 28,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 53,   angioG↑, 2,   ATF4↓, 1,   ATF4↑, 7,   ECM/TCF↓, 1,   EGFR↓, 19,   eNOS↓, 2,   eNOS↑, 1,   EPR↓, 1,   EPR↑, 1,   HIF-1↓, 4,   Hif1a↓, 34,   Hif1a↑, 1,   Hypoxia↓, 1,   miR-126↑, 1,   NO↓, 4,   NO↑, 2,   PDGFR-BB↓, 2,   p‑PDGFR-BB↓, 1,   VEGF↓, 58,   VEGFR2/KDR/Flk1↓, 7,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   BBB∅, 1,   CellMemb↑, 1,   GLUT1↓, 6,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↝, 1,   P-gp/ABCB1∅, 1,   SMCT1∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 45,   COX2/PTGS2↑, 3,   CRP↓, 2,   CXCR4↓, 9,   FOXP3↓, 1,   HCAR2↑, 1,   HMGB1↓, 3,   IFN-γ↓, 1,   IFN-γ↑, 3,   IKKα↓, 3,   IL1↓, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 9,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL6↓, 21,   IL8↓, 5,   Imm↑, 16,   Imm↝, 3,   INF-γ↑, 1,   Inflam↓, 19,   IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK2↓, 7,   M2 MC↓, 3,   MCP1/CCL2↓, 4,   MIP2↓, 1,   MyD88↑, 1,   NF-kB↓, 65,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 1,   NK cell↑, 9,   p65↓, 4,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 6,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 19,   PSA↓, 5,   PSA∅, 1,   T-Cell↑, 2,   T-Cell↝, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 2,   TLR4↑, 1,   TNF-α↓, 15,   TNF-α↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,   pH↑, 1,   e-pH↑, 4,   i-pH↓, 1,   TIM-3↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,   PP2A↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 10,   CDK6↓, 8,   CDK6↑, 4,   COMT↓, 2,   CYP19↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   GR↑, 1,   RANKL↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 19,   BioAv↑, 33,   BioAv↝, 13,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↓, 3,   ChemoSen↑, 137,   ChemoSen⇅, 2,   CYP1A2↓, 1,   CYP2C9↓, 1,   DDS↑, 1,   Dose?, 1,   Dose↓, 5,   Dose↑, 9,   Dose↝, 50,   Dose∅, 15,   eff↓, 32,   eff↑, 87,   eff↝, 5,   eff∅, 1,   Half-Life↓, 7,   Half-Life↑, 4,   Half-Life↝, 6,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 1,   P450↓, 1,   RadioS↑, 45,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 71,   Synergy↑, 434,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 4,   ALAT↑, 1,   ALP↓, 2,   AR↓, 10,   ascitic↓, 1,   AST↓, 2,   AST↑, 1,   BG↓, 3,   BRCA1↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 19,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 3,   Ferritin↓, 2,   FOXM1↓, 3,   GutMicro↑, 6,   HER2/EBBR2↓, 7,   hTERT/TERT↓, 10,   IL6↓, 21,   Ki-67↓, 17,   Ki-67↑, 1,   KRAS↓, 2,   LDH↓, 10,   p‑LDH↓, 1,   Myc↓, 4,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 5,   PSA∅, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 3,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 32,   AntiCan∅, 1,   antiNeop↑, 3,   AntiTum↓, 2,   AntiTum↑, 17,   cachexia↓, 1,   cardioP↑, 5,   CardioT↓, 1,   chemoP↑, 19,   chemoPv↑, 7,   ChemoSideEff↓, 11,   fatigue↓, 2,   hepatoP↓, 1,   hepatoP↑, 5,   memory↑, 1,   NDRG1↑, 1,   neuroP↑, 5,   NP/CIPN↓, 3,   OS↑, 30,   PDE4↓, 1,   Pin1↓, 2,   QoL↑, 7,   QoL∅, 1,   radioP↑, 7,   Remission↑, 3,   RenoP↑, 3,   Risk↓, 20,   Risk↑, 2,   Risk∅, 1,   toxicity↓, 20,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 5,   TumVol↓, 17,   TumW↓, 8,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↑, 7,   Sepsis↓, 2,  
Total Targets: 887

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 6,   compII↑, 1,   diuretic↑, 2,   NA↑, 1,   NeuroI↓, 1,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   Stress↓, 1,   Stroke↓, 3,   TRPA1↑, 1,   UFR↑, 1,   UR↓, 1,   β-HEX↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 5,   antiOx↑, 65,   Catalase↑, 26,   Copper↓, 1,   Fenton↓, 1,   Ferroptosis↓, 3,   GPx↑, 20,   GPx4↑, 1,   GSH↑, 24,   GSR↑, 3,   GSSG↓, 1,   GSSG∅, 1,   GSTA1↑, 1,   GSTs↑, 9,   H2O2↓, 1,   H2O2↑, 1,   H2O2∅, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 20,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↝, 1,   lipid-P↓, 23,   MDA↓, 19,   MDA↑, 1,   MPO↓, 4,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 38,   PARK2↑, 1,   Prx↑, 1,   RNS↓, 2,   ROS?, 1,   ROS↓, 73,   ROS↝, 1,   mt-ROS?, 1,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 35,   SOD2↑, 2,   TAC↑, 5,   TBARS↓, 1,   Trx↑, 1,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 2,   ATP↓, 1,   ATP↑, 7,   ATP↝, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   FIS1↓, 2,   Insulin↑, 1,   MMP↑, 5,   mtDam↓, 2,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   adiP↑, 1,   ALAT↓, 10,   AMPK↓, 1,   AMPK↑, 8,   p‑cMyc↑, 1,   CREB↑, 1,   CYP3A2↓, 1,   cytoP450↓, 1,   FASN↓, 1,   glucose↓, 5,   glucose↝, 1,   GlucoseCon↑, 2,   GLUT2↑, 1,   H2S↑, 1,   LDH↓, 3,   LDL↓, 6,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   PONs↑, 1,   PPARγ↓, 2,   PPARγ↑, 2,   p‑PPARγ↓, 1,   SIRT1↑, 6,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 2,   BAX↑, 1,   Bax:Bcl2↓, 2,   Bcl-2↓, 2,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 7,   Casp3↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 2,   Casp9↑, 1,   Cyt‑c↓, 3,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 3,   GADD34↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 10,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 7,   MAPK↑, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 2,   AKT1↓, 1,   TRPV3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 2,   other↓, 3,   other↑, 14,   other↝, 8,   other∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   GADD45A↑, 1,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   Diff↝, 1,   ERK↓, 3,   ERK↑, 2,   GH↑, 1,   GSK‐3β↓, 6,   p‑GSK‐3β↑, 1,   HDAC↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↓, 3,   mTOR↑, 1,   neuroG↑, 1,   PI3K↓, 5,   PI3K↑, 2,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 1,   TumCG∅, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 3,   AntiAg↑, 8,   AP-1↓, 3,   APP↓, 1,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 3,   Cartilage↑, 2,   Ki-67↓, 1,   LRP1↑, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 3,   MUC1↑, 1,   PKCδ?, 1,   PKCδ↓, 2,   PKCδ↑, 2,   RAGE↓, 2,   serineP↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   VCAM-1↓, 4,   ZO-1↑, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 2,   ATF4↓, 2,   EGFR↓, 1,   eNOS↓, 1,   EPR↑, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO?, 1,   NO↓, 9,   NO↑, 1,   TXA2↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 12,   BBB↝, 1,   GastroP↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 2,   OCLN↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 17,   COX2/PTGS2↑, 1,   CRP↓, 6,   ICAM-1↓, 3,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1?, 1,   IL1↓, 3,   IL10↓, 3,   IL10↑, 3,   IL12↓, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 20,   IL2↓, 2,   IL33↓, 1,   IL4↓, 2,   IL6?, 1,   IL6↓, 32,   IL8↓, 3,   Imm↓, 1,   Imm↑, 7,   Inflam↓, 86,   Inflam↑, 2,   LPS↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   MCP1/CCL2↝, 1,   MUC2↓, 1,   MyD88↓, 1,   NF-kB↓, 28,   PGE2↓, 8,   PSA↓, 2,   TLR2↓, 2,   TLR4↓, 2,   TLR4↑, 1,   TNF-α↓, 38,   TNF-α↑, 1,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   AChE↓, 8,   BChE↓, 2,   BDNF↓, 1,   BDNF↑, 5,   GABA↑, 2,   MAOA↓, 2,   NGF↑, 1,   tau↓, 6,   p‑tau↓, 6,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 16,   BACE/β-secretase↓, 7,   NLRP3↓, 8,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   DHT↓, 1,   Leptin↓, 1,   testos↓, 1,   testos↑, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 23,   BioAv↑, 45,   BioAv⇅, 2,   BioAv↝, 15,   BioEnh↑, 3,   ChemoSen↑, 1,   Dose↑, 4,   Dose↝, 25,   eff↓, 1,   eff↑, 15,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   MRP1/ABCC1↓, 1,   P450↓, 2,   selectivity↑, 2,   Synergy↑, 73,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 10,   ALP↓, 2,   AST↓, 13,   BloodF↑, 2,   BMD↑, 3,   BMPs↑, 1,   BP↓, 7,   BP↝, 1,   Calcium↑, 1,   creat↓, 2,   CRP↓, 6,   EGFR↓, 1,   GutMicro↑, 14,   Hcy/homoC↝, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 32,   Ki-67↓, 1,   LDH↓, 3,   Mag↑, 1,   MUC19↓, 1,   PSA↓, 2,   RAGE↓, 2,   Urea↓, 1,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 4,   antiAll↑, 9,   AntiArt↑, 4,   AntiCan↑, 10,   AntiDiabetic↑, 13,   AntiP↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP↓, 1,   cardioP↑, 31,   CardioT↓, 1,   chemoP↑, 10,   chemoPv↑, 5,   ChemoSideEff↓, 1,   cognitive↑, 24,   cognitive↝, 1,   hepatoP↑, 24,   memory↑, 20,   Mood↑, 1,   motorD↑, 3,   neuroP↓, 1,   neuroP↑, 55,   Obesity↓, 8,   Pain↓, 4,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 10,   Risk↓, 4,   Sleep↑, 2,   Strength↑, 1,   toxicity↓, 28,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 6,   toxicity∅, 6,   Weight↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1,   AntiFungal↑, 3,   AntiViral↑, 5,   Bacteria↓, 15,   Diar↓, 2,   IRF3↓, 1,   Sepsis↓, 1,  
Total Targets: 383

Scientific Paper Hit Count for: Synergy, Synergy
23 Curcumin
15 Vitamin C (Ascorbic Acid)
14 Quercetin
13 Chrysin
12 Sulforaphane (mainly Broccoli)
12 Dichloroacetate
11 Metformin
11 Lycopene
10 EGCG (Epigallocatechin Gallate)
9 Chemotherapy
9 Resveratrol
8 Silver-NanoParticles
8 Artemisinin
8 Ashwagandha(Withaferin A)
8 Fisetin
7 Atorvastatin
7 Berberine
7 immunotherapy
6 Radiotherapy/Radiation
6 Hyperthermia
6 Magnetic Fields
6 Apigenin (mainly Parsley)
6 Vitamin K2
6 Silymarin (Milk Thistle) silibinin
6 Inositol
6 Bicarbonate(Sodium)
6 Thymoquinone
5 Melatonin
5 Dipyridamole
5 Carvacrol
5 diet FMD Fasting Mimicking Diet
5 Fenbendazole
5 Formononetin
5 Gambogic Acid
5 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
5 Rosmarinic acid
4 3-bromopyruvate
4 Auranofin
4 Alpha-Lipoic-Acid
4 Gemcitabine (Gemzar)
4 Propolis -bee glue
4 Capsaicin
4 salinomycin
4 diet Methionine-Restricted Diet
4 Dandelion Root
4 Disulfiram
4 Hydrogen Gas
4 Phenethyl isothiocyanate
4 Piperlongumine
4 Urolithin
4 VitK3,menadione
3 1,8-Cineole
3 Photodynamic Therapy
3 Astaxanthin
3 beta-carotene(VitA)
3 borneol
3 Caffeic acid
3 Carnosic acid
3 chaetocin
3 chitosan
3 5-fluorouracil
3 Copper and Cu NanoParticles
3 Piperine
3 Emodin
3 Eugenol
3 Genistein (soy isoflavone)
3 Honokiol
3 Ivermectin
3 Juglone
3 Kaempferol
3 Luteolin
3 Matrine
3 Terpinen-4-ol / Tea Tree Oil
3 Selenium NanoParticles
2 2-DeoxyGlucose
2 cetuximab
2 Vitamin B12
2 Folic Acid, Vit B9
2 chemodynamic therapy
2 Trichostatin A
2 Allicin (mainly Garlic)
2 Andrographis
2 isoquercitrin
2 Aspirin
2 Baicalein
2 Biochanin A
2 Betulinic acid
2 Lutein
2 Zeaxanthin
2 hydroxychloroquine
2 Thymol-Thymus vulgaris
2 Sorafenib (brand name Nexavar)
2 Chlorogenic acid
2 Citric Acid
2 Coenzyme Q10
2 Ellagic acid
2 Bortezomib
2 Docosahexaenoic Acid
2 Oxygen, Hyperbaric
2 Vitamin A, Retinoic Acid
2 erastin
2 Exercise
2 Ferulic acid
2 ferumoxytol
2 Fucoidan
2 Gallic acid
2 Cisplatin
2 Gamma-aminobutyric acid
2 doxorubicin
2 Ginkgetin
2 Gossypol/AT-101
2 HydroxyCitric Acid
2 Spermidine
2 Lecithin
2 Niclosamide (Niclocide)
2 Phenylbutyrate
2 Shikonin
2 Selenite (Sodium)
2 Vitamin D3
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 EMF
1 SonoDynamic Therapy UltraSound
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anti-oxidants
1 Acer okamotoanum
1 5-Aminolevulinic acid
1 almonertinib
1 D-limonene
1 Huperzine A/Huperzia serrata
1 Bufalin/Huachansu
1 Bifidobacterium
1 Boron
1 Boswellia (frankincense)
1 Butyrate
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Beta‐Lapachone
1 Chlorophyllin
1 Rutin
1 Trastuzumab
1 Cinnamon
1 Hydroxycinnamic-acid
1 Selenium
1 Cucurbitacin
1 Dasatinib/Phyrago
1 Diclofenac
1 diet Ketogenic
1 Docetaxel
1 Ascorbyl Palmitate
1 Mistletoe/Viscum album Extracts
1 Echinacea
1 Electrical Pulses
1 Beta-Caryophyllene
1 temozolomide
1 Geldanamycin
1 Radicicol/monorden
1 Arsenic trioxide
1 olaparib/LYNPARZA
1 Galloflavin
1 verapamil
1 Garcinol
1 Ginkgo biloba
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginkgolide B
1 Gold NanoParticles
1 Calorie Restriction Mimetics
1 iodine
1 Inulin Prebiotic
1 isoorientin
1 itraconazole
1 Recombinant Methioninase
1 tumor necrosis factor-related apoptosis-inducing ligand
1 lambertianic acid
1 Lapatinib
1 low dose naltrexone
1 Licorice
1 Linalool
1 Vitamin E
1 Magnolol
1 methotrexate
1 Magnetic Field Rotating
1 Magnesium
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Naringin
1 Marjoram (Origanum majorana)
1 Paclitaxel/Taxol
1 Phosphatidylserine
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 Sulfasalazine
1 acetaminophen
1 acetazolamide
1 statins
1 triptolide
1 Turmerones
1 Vitexin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1849  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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