MMP Cancer Research Results

MMP, ΔΨm, mitochondrial membrane potential: Click to Expand ⟱
Source:
Type:
Destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Mitochondria are organelles within eukaryotic cells that produce adenosine triphosphate (ATP), the main energy molecule used by the cell. For this reason, the mitochondrion is sometimes referred to as “the powerhouse of the cell”.
Mitochondria produce ATP through process of cellular respiration—specifically, aerobic respiration, which requires oxygen. The citric acid cycle, or Krebs cycle, takes place in the mitochondria.
The mitochondrial membrane potential is widely used in assessing mitochondrial function as it relates to the mitochondrial capacity of ATP generation by oxidative phosphorylation. The mitochondrial membrane potential is a reliable indicator of mitochondrial health.
In cancer cells, ΔΨm is often decreased, which can lead to changes in cellular metabolism, increased glycolysis, increased reactive oxygen species (ROS) production, and altered cell death pathways.

The membrane of malignant mitochondria is hyperpolarized (−220 mV) in comparison to their healthy counterparts (−160 mV), which facilitates the penetration of positively charged molecules to the cancer cells mitochondria.
The MMP is a critical indicator of mitochondrial function, directly reflecting the organelle's capacity to generate ATP through oxidative phosphorylation.


Scientific Papers found: Click to Expand⟱
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
6364- DRE,    Dandelion Root Extract Sensitizes Leukemia Cells to VP-16 Induced Cell Death
- in-vitro, CLL, NA
TumCP↓, MMP↓, ROS↑, TumCD↑, ChemoSen↑, chemoP↑, QoL↑,
5012- DSF,  Cu,    Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems
ROS↑, ALDH↓, TumCP↓, CSCs↓, angioG↓, TumMeta↓, DNAdam↑, Proteasome↓, SOD1↓, GSR↓, ox-GSSG↑, GSH/GSSG↓, MMP↓, Akt↓, cycD1/CCND1↓, NF-kB↓, CSCs↓, MAPK↓, angioG↓, DrugR↓, EMT↓, Vim↓, BioAv↑, eff↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
989- EGCG,  Citrate,    In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
- in-vitro, HCC, NA - in-vivo, NA, NA
PFK↓, Glycolysis↓, lactateProd↓, GlucoseCon↓, TumCP↓, TumCCA↑, Casp3↑, cl‑PARP↑, Apoptosis↑, Casp8↑, Casp9↑, Cyt‑c↝, MMP↓, BAD↑, GLUT2↓, PKM2∅,
655- EGCG,    A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells
- in-vitro, HCC, HepG2
AFP↓, TumAuto↑, LC3II↑, TumCG↓, MMP↓,
3219- EGCG,    Nano-chemotherapeutic efficacy of (−) -epigallocatechin 3-gallate mediating apoptosis in A549 cells: Involvement of reactive oxygen species mediated Nrf2/Keap1signaling
- in-vitro, Lung, A549
ROS↑, RNS↓, MMP↓, NRF2↑, Keap1↓,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, eff↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
3207- EGCG,    EGCG Enhances the Chemosensitivity of Colorectal Cancer to Irinotecan through GRP78-MediatedEndoplasmic Reticulum Stress
- in-vitro, CRC, RKO - in-vitro, CRC, HCT116
GRP78/BiP↑, MMP↓, ER Stress↑, ROS↓, UPR↑,
1974- EGCG,    Protective Effect of Epigallocatechin-3-Gallate in Hydrogen Peroxide-Induced Oxidative Damage in Chicken Lymphocytes
- in-vitro, Nor, NA
*ROS↓, *NO↓, *MMP↑, *i-Ca+2↓, *HO-1↑, *Catalase↑, *NRF2↑, *Trx1↑, *antiOx↑, *SOD↑, *Apoptosis↓,
1976- EGCG,    Epigallocatechin-3-gallate exhibits anti-tumor effect by perturbing redox homeostasis, modulating the release of pro-inflammatory mediators and decreasing the invasiveness of glioblastoma cells
- in-vitro, GBM, U87MG
ROS↑, MMP↓, Casp3↑, Cyt‑c↑, Trx1↓, Ceru↓, IL6↓, IL8↓, MCP1↓, RANTES?, uPA↝, ROS↑,
5223- EMD,    Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
- in-vitro, CRC, DLD1 - in-vitro, Nor, CCD841
tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,
1245- EMD,    Emodin Exhibits Strong Cytotoxic Effect in Cervical Cancer Cells by Activating Intrinsic Pathway of Apoptosis
- in-vitro, Cerv, HeLa
TumCG↓, TumCP↓, Apoptosis↑, ROS↑, Casp3↑, Casp9↑, MMP↓, DNAdam↑, GSH↓,
1332- EMD,    Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway
- in-vivo, Nor, HepaRG
*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,
1327- EMD,    Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway
- in-vitro, Lung, A549
Cyt‑c↑, Casp2↑, Casp3↑, Casp9↑, ERK↓, Akt↓, ROS↑, MMP↓, Bcl-2↓, BAX↑,
1323- EMD,    Anticancer action of naturally occurring emodin for the controlling of cervical cancer
- Review, Cerv, NA
TumCCA↑, DNAdam↑, mTOR↓, Casp3↑, Casp8↑, Casp9↑, TGF-β↑, SMAD3↓, p‑SMAD4↓, ROS↑, MMP↓, CXCR4↓, HER2/EBBR2↓, ER Stress↓, TumAuto↑, NOTCH1↓,
1324- EMD,    Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin
- Review, Var, NA
*toxicity↑, *BioAv↓, Akt↓, ERK↓, ROS↑, MMP↓, Bcl-2↓, BAX↑, TumCCA↑,
1321- EMD,    Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model
- in-vitro, CRC, LS1034 - in-vivo, NA, NA
tumCV↓, TumCCA↑, ROS↑, Ca+2↑, MMP↓, Apoptosis↑, Cyt‑c↑, Casp9↑, Bax:Bcl2↑,
1318- EMD,    Aloe-emodin Induces Apoptosis in Human Liver HL-7702 Cells through Fas Death Pathway and the Mitochondrial Pathway by Generating Reactive Oxygen Species
- in-vitro, Nor, HL7702
*TumCCA↑, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↓, *Bax:Bcl2↑, *cl‑Casp3↑, *cl‑Casp8↑, *cl‑Casp9↑, *cl‑PARP↑,
1328- EMD,    Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways
- in-vitro, Tong, SCC4
TumCCA↑, P21↑, Chk2↑, CycB/CCNB1↓, cDC2↓, Apoptosis↑, Cyt‑c↑, Casp9↑, Casp3↑, ROS↑, MMP↓, Bax:Bcl2↑, ER Stress↑,
1329- EMD,    Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells
- in-vitro, Tong, SCC4
TumCCA↑, eff↓, P53↑, P21↑, p27↑, cycA1/CCNA1↓, cycE/CCNE↓, TS↓, CDC25↓, AIF↑, proCasp9↓, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp9↑,
1331- EMD,    Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway
- in-vitro, NPC, NA
TumCCA↑, CycB/CCNB1↑, DNAdam↑, Casp3↑, cl‑PARP↑, MMP↓, Ca+2↑, ROS↑,
1296- EMD,    Emodin inhibits LOVO colorectal cancer cell proliferation via the regulation of the Bcl-2/Bax ratio and cytochrome c
- in-vitro, CRC, LoVo
BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑,
1330- EMD,    Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway
- in-vitro, NA, NA
tumCV↓, Casp3↑, Casp9↑, MMP↓, Cyt‑c↑, BAX↑, Bax:Bcl2↑,
3460- EP,    Picosecond pulsed electric fields induce apoptosis in HeLa cells via the endoplasmic reticulum stress and caspase-dependent signaling pathways
- in-vitro, Cerv, HeLa
tumCV↓, Apoptosis↑, TumCCA↑, GRP78/BiP↑, GRP94↑, CEBPA↑, CHOP↑, Ca+2↑, Casp12↑, Casp9↑, Casp3↑, Cyt‑c↑, BAX↑, Bcl-2↓, ER Stress↑, MMP↓,
5256- EP,    Pulsed electric fields: a sharp sword in the battle against cancers
- Review, Var, NA
BioAv↑, TumCD↑, MMP↓, Apoptosis↑, TumCCA↑, Imm↑, RadioS↑, ChemoSen↑,
5525- EP,    Cell responses without receptors and ligands, using nanosecond pulsed electric fields (nsPEFs)
- Review, Var, NA
CellMemb↑, Ca+2↑, ER Stress↑, ROS↑, MMP↓, VGCC↓, VGSC↓, Dose↝,
5530- EP,    Expression of voltage-gated calcium channels augments cell susceptibility to membrane disruption by nanosecond pulsed electric field
- in-vitro, Nor, HEK293
*CellMemb↑, *VGCC↑, *Ca+2↑, *MMP↓, *VGCC⇅, eff↑,
5526- EP,    Nanosecond Pulsed Electric Field Modulates Electron Transport and Mitochondrial Structure and Function
- Review, Var, NA
CellMemb↑, ROS↑, ETC↝, OCR↓, MMP↓,
5529- EP,    Effects of nsPEFs on Electron Transport and Mitochondrial Structures and Functions
- Review, Var, NA
ETC↓, OCR↓, CellMemb↑, mt-ROS↑, MMP↓,
5494- EP,    An Overview of Subnanosecond Pulsed Electric Field Biological Effects: Toward Contactless Technologies for Cancer Treatment
- Review, Var, NA
other↝, ROS↑, Temp∅, CellMemb↑, Ca+2↑, Apoptosis↑, TumCD↑, MMP↓, necrosis↑, TumVol↓, Remission↑,
5519- EP,    Nanosecond Pulsed Electric Fields (nsPEFs) for Precision Intracellular Oncotherapy: Recent Advances and Emerging Directions
- Review, Var, NA
MMP↓, Ca+2↑, eff↑, ER Stress↑, selectivity↑, CSCs↓, CD44↓, CD133↓, ROS↑, Imm↑, DNAdam↑, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp9↑, TumCD↑, Fas↑, UPR↑, Dose↝, Dose↝, Dose↓, Dose↑, HMGB1↓, eff↑, EPR↑, ChemoSen↑, ETC↝, *AntiAge↑, *Hif1a↑, *SIRT1↑,
5522- EP,    Nanosecond pulsed electric field suppresses growth and reduces multi-drug resistance effect in pancreatic cancer
- in-vitro, PC, NA
AntiCan↑, Dose↝, CellMemb↑, ChemoSen↑, MMP↓,
5523- EP,    Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication
- vitro+vivo, Nor, HUVECs
*MMP↑, *Hif1a↑, *SIRT1↑, *ROS↓, *AntiAge↑, *Dose↝, *angioG↑,
6355- Eug,    Pharmacological and Toxicological Properties of Eugenol
- Review, Var, NA
*Inflam↓, *antiOx↑, *NF-kB↓, *AntiArt↑, *lipid-P↓, *GSH↑, ROS↑, GSH↓, ChemoSen↑, Apoptosis↑, MMP↓, TumCG↓, TumCCA↑,
6377- Eug,    Pharmacological Properties and Health Benefits of Eugenol: A Comprehensive Review
- Review, Var, NA - Review, AD, NA
*Inflam↓, *Bacteria↓, ChemoSen↑, *selectivity↑, ROS⇅, TumCG↓, MMP↓, antiOx⇅, *antiOx↑, *BBB↑, *neuroP↑, *BDNF↑, *Aβ↓, *Ca+2↓, *5LO↓, *MAOA↓, other↑,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27↑, NF-kB↓, COX2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *eff↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6325- Eug,    Anticancer Properties of Eugenol: A Review
- Review, Var, NA
*antiOx↑, *AntiCan↑, *Inflam↓, TumCD↑, TumCCA↑, TumCMig↓, TumMeta↓, angioG↓, ChemoSen↑, chemoP↑, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *Bacteria↓, *ROS↓, *IL6↓, *COX2↓, *TNF-α↓, *lipid-P↓, *SOD1↑, *Catalase↑, *GPx1↑, *GSTs↑, ROS↑, MMP↓, Apoptosis↑, COX2↓, TumCCA↑, E2Fs↓, PI3K↓, Akt↓, MMPs↓, CSCs↓, OCT4↓, CD44↓, EpCAM↓, NOTCH1↓, TumVol↓, Casp3↑, P53↑, cl‑PARP↑, MMP2↓, MMP9↓, TIMP1↑, ALDH↓, NF-kB↓, *toxicity↓,
3783- FA,    Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer’s Disease
- NA, AD, NA
*ROS↓, *IronCh↑, *NLRP3↓, *Aβ↓, *AChE↓, *BChE↓, *antiOx↑, *BBB↑, *MMP↑, *memory↑, *SOD↑, *Catalase↑,
3780- FA,    Ferulic Acid: A Natural Antioxidant with Application Towards Neuroprotection Against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑, *AChE↓, *MMP↑,
3713- FA,    Protective Effect of Ferulic Acid on Acetylcholinesterase and Amyloid Beta Peptide Plaque Formation in Alzheimer’s Disease: An In Vitro Study
- Review, AD, NA
*AChE↓, *antiOx↑, *neuroP↑, *Aβ↓, *MMP↓, *XO↓, *SOD↑, *lipid-P↑, *ROS↓,
2496- Fenb,    Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H460
TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,
2853- FIS,    Fisetin Inhibits Cell Proliferation and Induces Apoptosis via JAK/STAT3 Signaling Pathways in Human Thyroid TPC 1 Cancer Cells
- in-vitro, Thyroid, TPC-1
Apoptosis↑, ROS↑, MMP↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, JAK1↓, STAT3↓,
2856- FIS,    N -acetyl- L -cysteine enhances fisetin-induced cytotoxicity via induction of ROS-independent apoptosis in human colonic cancer cells
- in-vitro, Colon, COLO205
eff↑, ROS↑, tumCV↓, Casp3↑, Bcl-2↓, MMP↓, eff↑,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP↑, eff↑, ChemoSen↑,
2844- FIS,    Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells
- in-vitro, OS, U2OS
tumCV↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, BAD↑, Bcl-2↓, Bcl-xL↓, PI3K↓, Akt↓, ERK↓, p‑JNK↑, p‑cJun↑, p‑p38↑, ROS↑, MMP↓, mTORC1↓, PTEN↑, p‑GSK‐3β↓, GSK‐3β↑, NF-kB↓, IKKα↑, Cyt‑c↑,

Showing Research Papers: 251 to 300 of 599
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 599

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx⇅, 1,   ATF3↑, 1,   Ceru↓, 1,   GSH↓, 3,   GSH/GSSG↓, 1,   GSR↓, 1,   ox-GSSG↑, 1,   GSTs↑, 1,   GSTs↝, 1,   HO-1↓, 2,   HO-2↓, 1,   Keap1↓, 1,   MAD↓, 1,   NRF2↓, 1,   NRF2↑, 1,   RNS↓, 1,   ROS↓, 1,   ROS↑, 31,   ROS⇅, 1,   mt-ROS↑, 1,   SOD1↓, 1,   TBARS↑, 1,   Thiols↓, 1,   Trx1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   CDC2↓, 1,   CDC25↓, 2,   ETC↓, 1,   ETC↝, 2,   MEK↓, 1,   MMP↓, 41,   MMP↑, 1,   mtDam↑, 1,   OCR↓, 3,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   AMPK↑, 1,   cMyc↓, 1,   ECAR↝, 1,   GlucoseCon↓, 2,   GLUT2↓, 1,   Glycolysis↓, 2,   lactateProd↓, 3,   LDH↓, 1,   PDH↝, 1,   PDK1?, 2,   PDK1↓, 1,   PFK↓, 1,   PKM2∅, 1,   SIRT1↓, 2,   TS↓, 1,  

Cell Death ⓘ

Akt↓, 10,   Akt↑, 1,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 19,   BAD↓, 1,   BAD↑, 5,   Bak↑, 1,   BAX↑, 11,   Bax:Bcl2↑, 6,   Bcl-2↓, 12,   Bcl-xL↓, 3,   BIM↑, 1,   Casp↑, 1,   Casp1↑, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↑, 23,   Casp8↓, 1,   Casp8↑, 6,   cl‑Casp8↑, 1,   Casp9↑, 15,   proCasp9↓, 1,   Chk2↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 15,   Cyt‑c↝, 1,   Diablo↑, 2,   DR4↑, 1,   DR5↑, 3,   Fas↑, 4,   iNOS↓, 2,   JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 4,   Mcl-1↓, 2,   MDM2↓, 2,   MOMP↑, 1,   Myc↓, 2,   necrosis↑, 1,   NOXA↑, 2,   p27↑, 2,   p‑p38↑, 1,   Proteasome↓, 1,   PUMA↑, 1,   survivin↓, 3,   Telomerase↓, 1,   TRAIL↑, 2,   TumCD↑, 7,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   p‑cJun↑, 1,   other↑, 1,   other↝, 1,   tumCV↓, 7,  

Protein Folding & ER Stress ⓘ

CHOP↑, 6,   eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 9,   GRP78/BiP↑, 4,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 3,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3B↑, 1,   LC3II↑, 3,   TumAuto↑, 4,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNAdam↑, 7,   P53↑, 10,   PARP↓, 2,   PARP↑, 2,   cl‑PARP↑, 7,   PCNA↓, 1,   SIRT6↑, 1,   TP53↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 3,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 7,   cycE/CCNE↓, 3,   E2Fs↓, 2,   P21↓, 1,   P21↑, 5,   p‑RB1↓, 2,   Securin↓, 1,   TumCCA↓, 1,   TumCCA↑, 19,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 2,   CD133↓, 1,   CD44↓, 3,   cDC2↓, 1,   CDK8↓, 1,   CEBPA↑, 1,   cFos↓, 1,   CIP2A↓, 1,   CSCs↓, 5,   Diff↓, 1,   EMT↓, 3,   EpCAM↓, 2,   ERK↓, 3,   p‑ERK↓, 2,   FOXO3↝, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   IGF-1R↑, 1,   mTOR↓, 4,   mTORC1↓, 1,   NOTCH↓, 3,   NOTCH1↓, 3,   NOTCH3↓, 1,   OCT4↓, 2,   PI3K↓, 6,   PTEN↑, 2,   STAT↓, 1,   STAT3↓, 2,   p‑STAT3↓, 2,   TCF↑, 1,   TumCG↓, 6,   VGCC↓, 1,   VGSC↓, 1,   Wnt↓, 2,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

Ca+2↑, 6,   Ca+2↝, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   p‑FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   MMP2↓, 5,   MMP9↓, 5,   MMPs↓, 2,   N-cadherin↓, 1,   PKCδ↓, 2,   RECK↑, 1,   Slug↓, 1,   SMAD3↓, 2,   p‑SMAD4↓, 1,   Snail↓, 4,   TGF-β↓, 1,   TGF-β↑, 2,   TIMP1↑, 2,   TIMP2↑, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 6,   TumMeta↓, 5,   Twist↓, 1,   uPA↓, 1,   uPA↝, 1,   VEGFR1↓, 1,   Vim↓, 3,   Zeb1↓, 1,   Zeb1↑, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 6,   ATF4↑, 2,   EGFR↓, 3,   Endoglin↑, 1,   EPR↑, 1,   Hif1a↓, 2,   VEGF↓, 3,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

CellMemb↑, 5,   GLUT1↓, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 7,   CXCR4↓, 1,   HMGB1↓, 1,   IKKα↑, 2,   IL6↓, 2,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 3,   JAK↓, 1,   JAK1↓, 1,   MCP1↓, 1,   NF-kB↓, 11,   NF-kB↑, 1,   p‑NF-kB↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 2,   RANTES?, 1,   TLR4↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Cellular Microenvironment ⓘ

Temp∅, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 11,   Dose↓, 1,   Dose↑, 1,   Dose↝, 6,   Dose∅, 1,   DrugR↓, 1,   eff↓, 2,   eff↑, 10,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 1,   P450↝, 1,   RadioS↑, 5,   selectivity↑, 9,  

Clinical Biomarkers ⓘ

AFP↓, 1,   EGFR↓, 3,   HER2/EBBR2↓, 2,   IL6↓, 2,   Ki-67↓, 1,   LDH↓, 1,   Myc↓, 2,   PD-L1↓, 1,   TP53↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   antiNeop↑, 1,   chemoP↑, 2,   ChemoSideEff↓, 1,   QoL↑, 1,   Remission↑, 1,   Risk↓, 1,   TumVol↓, 3,  
Total Targets: 284

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiArt↑, 2,  

Redox & Oxidative Stress ⓘ

antiOx↑, 9,   Catalase↑, 6,   GPx↑, 1,   GPx1↑, 1,   GSH↑, 1,   GSTs↑, 3,   HO-1↑, 2,   lipid-P↓, 3,   lipid-P↑, 1,   MPO↓, 1,   NRF2↑, 1,   RNS↓, 1,   ROS↓, 9,   ROS↑, 2,   SOD↓, 1,   SOD↑, 5,   SOD1↑, 1,   Trx1↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 4,   MMP↑, 4,  

Core Metabolism/Glycolysis ⓘ

glucose↓, 1,   LDL↓, 1,   SIRT1↑, 2,  

Cell Death ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bax:Bcl2↑, 2,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Fas↑, 2,   iNOS↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   P53↑, 2,   cl‑PARP↑, 2,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   P21↓, 1,   P21↑, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

VGCC↑, 1,   VGCC⇅, 1,  

Migration ⓘ

5LO↓, 1,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 1,   i-Ca+2↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   Hif1a↑, 2,   NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,   CellMemb↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL6↓, 2,   Inflam↓, 6,   NF-kB↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   BChE↓, 1,   BDNF↑, 1,   MAOA↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 3,   NLRP3↓, 1,   XO↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioAv↝, 1,   Dose↝, 1,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

AntiAge↑, 2,   AntiCan↑, 1,   cardioP↑, 2,   memory↑, 2,   neuroP↑, 6,   Pain↓, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 3,  
Total Targets: 89

Scientific Paper Hit Count for: MMP, ΔΨm, mitochondrial membrane potential
31 Silver-NanoParticles
25 Quercetin
21 Betulinic acid
21 Capsaicin
17 Baicalein
17 Propolis -bee glue
16 Berberine
16 Fisetin
15 Curcumin
15 Shikonin
15 Thymoquinone
14 Magnetic Fields
14 Sulforaphane (mainly Broccoli)
13 Apigenin (mainly Parsley)
13 Emodin
11 Chrysin
11 Resveratrol
10 Ashwagandha(Withaferin A)
10 Electrical Pulses
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
9 Vitamin K2
8 Allicin (mainly Garlic)
8 Dichloroacetate
8 Gambogic Acid
8 Graviola
8 Phenethyl isothiocyanate
7 Radiotherapy/Radiation
7 Dandelion Root
7 EGCG (Epigallocatechin Gallate)
7 Honokiol
7 Phenylbutyrate
7 salinomycin
6 chitosan
6 Beta-Caryophyllene
6 Carvacrol
6 Juglone
6 Luteolin
6 Parthenolide
5 Alpha-Lipoic-Acid
5 Cisplatin
5 Artemisinin
5 doxorubicin
5 Rosmarinic acid
5 Eugenol
5 Lycopene
5 Magnetic Field Rotating
5 Selenium NanoParticles
5 Ursolic acid
4 Auranofin
4 Vitamin C (Ascorbic Acid)
4 Metformin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Selenium
4 Copper and Cu NanoParticles
4 Propyl gallate
4 Taurine
3 SonoDynamic Therapy UltraSound
3 Boron
3 Thymol-Thymus vulgaris
3 Crocetin
3 Carvone
3 Date Fruit Extract
3 Ellagic acid
3 Ferulic acid
3 Garcinol
3 Geraniol
3 HydroxyTyrosol
3 Linalool
3 Piperlongumine
3 Spermidine
3 Urolithin
2 Astragalus
2 Gemcitabine (Gemzar)
2 5-fluorouracil
2 Anethole/trans-Anethole
2 Baicalin
2 Biochanin A
2 Bufalin/Huachansu
2 Celecoxib
2 Celastrol
2 Cinnamon
2 Hydroxycinnamic-acid
2 Citric Acid
2 Coenzyme Q10
2 Gallic acid
2 Paclitaxel
2 γ-linolenic acid (Borage Oil)
2 Gold NanoParticles
2 Hyperthermia
2 Photodynamic Therapy
2 Magnolol
2 Nimbolide
2 Piperine
2 Plumbagin
2 Psoralidin
2 VitK3,menadione
1 2-DeoxyGlucose
1 Glucose
1 Camptothecin
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Astaxanthin
1 Atorvastatin
1 Aloe anthraquinones
1 Berbamine
1 D-limonene
1 Cannabidiol
1 Brucea javanica
1 Bromelain
1 Chemotherapy
1 Bruteridin(bergamot juice)
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chlorogenic acid
1 Chocolate
1 Vitamin E
1 Cucurbitacin
1 Cyclopamine
1 Mistletoe
1 Disulfiram
1 Fenbendazole
1 Shilajit/Fulvic Acid
1 hydroxychloroquine
1 Ginkgo biloba
1 1,8-Cineole
1 Methylene blue
1 Methyl Jasmonate
1 Melatonin
1 Methylglyoxal
1 Moringa oleifera
1 Mushroom Chaga
1 Bicarbonate(Sodium)
1 No Product/Mechanism Only
1 Oleuropein
1 temozolomide
1 Pterostilbene
1 Kaempferol
1 Oxaliplatin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Sulfasalazine
1 polyethylene glycol
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:197  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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