NF-kB Cancer Research Results

NF-kB, Nuclear factor kappa B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
NF-kB signaling
Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival.
NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis.
Scientific Papers found: Click to Expand⟱
5941- Cela,    Celastrol inhibits migration and invasion through blocking the NF-κB pathway in ovarian cancer cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, OVCAR-3
TumCMig↓, TumCI↓, NF-kB↓, p65↓, MMP9↓, eff↑, AntiTum↑, Inflam↓, AntiDiabetic↑,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
5951- Cela,    Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer
- vitro+vivo, Pca, NA
NF-kB↓, AR↓, MCP1↓, Akt↓, HSP90↓, TumCG↓,
6615- Cen,    Asiaticoside suppresses cell proliferation by inhibiting the NF-κB signaling pathway in colorectal cancer
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
Dose↝, TumCP↓, selectivity↑, MMP↓, Apoptosis↑, TumCCA↑, NF-kB↓, CDK4↓, cycD1/CCND1↓, Casp9↑, Casp3↑, Bax:Bcl2↑, TumCG↓, ChemoSen↑, TNF-α↓, IL1β↓, P53↑, P21↑,
6641- Cen,    Asiaticoside Increases Caspase-9 Activity in MCF-7 Cells and Inhibits TNF-α and IL-6 Expression in Nude Mouse Xenografts via the NF-κB Pathway
- in-vitro, BC, MCF7
Casp9↑, TNF-α↓, IL6↓, NF-kB↓, TumCG↓, Inflam↓, TumCP↓, EMT↓,
6018- CGA,    Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems
- Review, Var, NA - Review, RCC, NA
*BioAv↓, *Inflam↓, *TNF-α↓, *NO↓, *COX2↓, *PGE2↓, *NF-kB↓, *IL6↓, *IL1β↓, *TLR2↓, *MAPK↓, *NRF2↓, *HO-1↑, *NQO1↑, *cardioP↑, *neuroP↑, *SOD↑, *GSH↑, *ROS↓, *LDH↓, *MDA↓, *cognitive↑, *eff↑,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *eff↑, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6013- CGA,    Advances in Pharmacological Properties, Molecular Mechanisms, and Bioavailability Strategies of Chlorogenic Acid in Cardiovascular Diseases Therapy
- Review, CardioV, NA
*BioAv↝, *BioAv↝, *BP↓, *ROS↓, *NADPH↓, *AntiAg↑, *TXA2↓, *antiOx↑, *cardioP↑, *Inflam↓, *SOD↑, *Catalase↑, *Ferroptosis↓, *NF-kB↓, *JNK↓, *NRF2↑, *HO-1↑, *toxicity↓, *BioAv↓, *BioAv↑, *BioAv↑, eff↑,
6006- CGA,    Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF-κB signaling pathway
- in-vitro, BC, NA
NF-kB↓, AntiTum↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6011- CGA,    Chlorogenic Acid’s Role in Metabolic Health: Mechanisms and Therapeutic Potential
- Review, Nor, NA
*BioAv↓, *antiOx↑, *Inflam↓, *Bacteria↓, *hepatoP↑, *cardioP↑, *neuroP↑, *ROS↓, *NF-kB↓, *NRF2↑, *Obesity↓, *GutMicro↑, *AntiAg↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *OCLN↓, *VEGF↓, BioAv↝,
6030- CGA,    Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453 - in-vitro, Nor, MCF10
NF-kB↓, AntiTum↑, tumCV↓, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, TumCG↓, OS↑, TumMeta↓, CD4+↑, CD8+↑, Imm↑,
6023- CGA,    Pharmacological advances of the chlorogenic acids family: current insights and future research directions
- Review, AD, NA - Review, Park, NA - Review, IBD, NA
*Aβ↓, *neuroP↑, *cardioP↑, *GastroP↑, *RenoP↑, *hepatoP↑, *Obesity↓, *Bacteria↓, *BioAv↑, *BioAv↑, *BioAv↑, *ROS↓, *GutMicro↑, *IBI↑, *MCT1↓, *NF-kB↓, *DNMT1↓,
5986- Chit,    The natural product chitosan enhances the anti-tumor activity of natural killer cells by activating dendritic cells
- Study, Var, NA
NK cell↑, IFN-γ↑, IL12↑, IL15↑, STAT4↑, NF-kB↑, DCells↑,
6079- CHL,    Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice
- in-vivo, Nor, NA
*eff↑, *GutMicro↑, *NF-kB↓, *MMPs↑, *TIMP1↓, *Inflam↓, *Dysb↓,
6068- CHL,    Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis
- in-vivo, Oral, NA
NF-kB↓, IKKα↓, Apoptosis↓, Bcl-2↑, survivin↓, Casp↑, cl‑PARP↑,
6083- CHOC,    Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer
- Review, Colon, NA
ROS↓, Inflam↓, TumCP↓, Apoptosis↑, *Dose↝, *BioAv↓, *BioAv↑, GSH↑, GSTs↑, PGE2↓, COX1↑, IL8↓, COX2↓, iNOS↓, NF-kB↓, chemoP↑,
6084- CHOC,    Cocoa Polyphenols and Their Potential Benefits for Human Health
- Review, Nor, NA - Review, Stroke, NA - Review, IBD, NA
*lipid-P↓, *ROS↓, *Inflam↓, *BP↓, *cardioP↑, *chemoPv↑, *BioAv⇅, *antiOx↑, *Risk↓, *5LO↓, *AntiAg↑, *Imm↑, *NF-kB↓, *other↓, CYP1A1↓, COX2↓, *Obesity↓, *cognitive↑,
6085- CHOC,    Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model
- in-vivo, PC, NA
selectivity↑, TumCP↓, p‑Akt↓, NF-kB↓, TumCG↓, *BioAv↑, *chemoPv↑,
6133- CHr,    Chrysin in PI3K/AKT and other apoptosis signalling pathways, and its effect on HeLa cells.
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↓, eff↑, CYP19↓, Hif1a↓, VEGF↓, NF-kB↓, PI3K↓, Akt↓,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
2796- CHr,    Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice
- in-vivo, Lung, NA
PCNA↓, COX2↓, NF-kB↓, chemoPv↑, *SOD↑, *Catalase↓, *GR↓, *GPx↓, *lipid-P↓, *COX2↓, *NF-kB↓, *ROS↓,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
6631- Cic,    Chicoric acid is a potent anti-atherosclerotic ingredient by anti-oxidant action and anti-inflammation capacity.
- in-vitro, Nor, NA
*MMP↑, *BAX↓, *DNAdam↓, *Casp3↓, *NF-kB↓, *antiOx↑, *Inflam↓,
6625- Cic,  Ech,    Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB
- in-vivo, NA, NA
*memory↑, *Aβ↓, *BACE↓, *MAPK↓, *NF-kB↓, *NF-kB↓, *iNOS↓, *COX2↓, *IL1β↓, *TNF-α↓, *BDNF∅, *MMPs↓,
6626- Cic,  Ech,    Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer’s Disease Models
- in-vivo, Nor, NA
*antiOx↑, *Obesity↓, *memory↑, *Aβ↓, *MAPK↓, *NF-kB↓, *iNOS↓, *COX2↓, *IL1β↓, *TNF-α↓, *NF-kB↓,
1055- Cin,    Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1
- vitro+vivo, Melanoma, NA - vitro+vivo, CRC, NA - vitro+vivo, lymphoma, NA
TumCP↓, NF-kB↓, AP-1↓, Bcl-2↓, Bcl-xL↓, survivin↓,
6164- Cin,    Advances in pharmacological effects and mechanism of action of cinnamaldehyde
- Review, Var, NA - Review, PSA, NA
*glucose↑, *cardioP↑, *Inflam↓, *lipid-P↓, GutMicro↑, TumCP↓, Apoptosis↑, TumCI↓, TumCMig↓, BAX↑, P53↑, Bcl-2↓, IAP1↓, PI3K↓, Akt↓, *ROS↓, *NRF2↑, *NF-kB↓, NF-kB↑,
6141- Cin,    The role and mechanism of cinnamaldehyde in cancer
- Review, Var, NA
Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, eff↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
1567- Cin,    Cinnamon: Mystic powers of a minute ingredient
- Review, Var, NA
other∅, cognitive↑, antiOx↑, lipid-P↓, Apoptosis↑, NF-kB↓,
6146- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high‐fat diet
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCG↓, SPARC↑, Glycolysis↓, OCR↓, ATP↓, NF-kB↓, Ca+2↑,
6316- Cro,    NF-kB_and_NLRP3_pathway_inhibition">Crocin suppresses prostate cancer progression via TLR4/NF-κB and NLRP3 pathway inhibition
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, 22Rv1
TumCI↓, Apoptosis↑, TLR4↓, NF-kB↓, IKKα↓, NLRP3↓, TumCG↓,
6315- Cro,    Functional Mechanisms of Dietary Crocin Protection in Cardiovascular Models under Oxidative Stress
- in-vivo, NA, NA
*cardioP↑, *Inflam↓, *antiOx↑, *ROS↓, *AntiCan↑, *memory↑, *NF-kB↓, *TLR1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *DNAdam↓, PTEN↓, MMP↓,
6304- Cro,    Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ
- in-vitro, BC, NA
NF-kB↓, tumCV↓, TumCP↓, TNF-α↓, IL1β↓, Inflam↓, PRKCQ/PKCθ↓,
6303- Cro,    Crocetin treatment inhibits proliferation of colon cancer cells through down-regulation of genes involved in the inflammation
- in-vitro, CRC, HCT116 - in-vitro, CRC, DU145
NF-kB↓, VEGF↓, MMP9↓, Inflam↓, HMGB1↓, IL6↓, IL8↓, TumCG↓, Apoptosis↑,
6301- Cro,    Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways
- vitro+vivo, Colon, HT29 - in-vitro, Colon, Caco-2
tumCV↓, selectivity↑, TumCMig↓, TumCI↓, angioG↓, TNF-α↓, NF-kB↓, VEGF↓, TumMeta↓,
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,
6297- Cro,    Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-κB/iNOS Pathway and Nrf2/HO-1 Pathway
- in-vitro, Nor, RAW264.7
*NO↓, *iNOS↓, *Inflam↓, *MEK↓, JNK↓, NF-kB↓, NRF2↑, HO-1↑, hepatoP↑, neuroP↑,
3635- Cro,    A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures
- Review, NA, NA
*memory↑, *cognitive↑, *BioAv↑, *ROS↓, *IL1↓, *TNF-α↓, *NF-kB↓, *neuroP↑, *lipid-P↓, *Thiols↑, *antiOx↑, *AChE↓, *MAOA↝, *SIRT1↑, *PGC-1α↑, *Ach↑,
6529- CRV,    D-Carvone Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting Oxidative Stress and TGF-ß 1/SMAD3 Signaling Pathway
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *SOD↑, *GSH↑, *TAC↑, *eff↑, *TGF-β1↓, *SMAD3↓, *MMP9↑, *NRF2↑, *antiOx↑, *hepatoP↑, *Inflam↓, *NF-kB↓, *NO↓, *cAMP↑, *ROS↓,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,

Showing Research Papers: 251 to 300 of 837
Prev Page 6 of 17 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 837

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PRKCQ/PKCθ↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   CYP1A1↓, 1,   Fenton↑, 1,   GSH↓, 2,   GSH↑, 1,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 4,   lipid-P↓, 1,   lipid-P↑, 2,   NQO1↑, 1,   NRF2↓, 5,   NRF2↑, 3,   Prx↓, 1,   PrxII↓, 1,   ROS↓, 2,   ROS↑, 13,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   mt-ATP↓, 1,   mitResp↓, 1,   MMP↓, 6,   MMP↑, 1,   mtDam↑, 3,   OCR↓, 1,   XIAP↓, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   cMyc↓, 2,   glucose↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 6,   HK2↓, 4,   lactateProd↓, 2,   LDH↓, 1,   LDHA↓, 1,   LDL↓, 1,   PDK1↓, 2,   PDK3↑, 1,   PPARα↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 12,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 20,   Bak↑, 1,   BAX↑, 6,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Bcl-2↑, 1,   Bcl-xL↓, 2,   Casp↑, 4,   Casp3↑, 9,   Casp9↑, 7,   Cyt‑c↑, 5,   hTERT/TERT↓, 4,   IAP1↓, 1,   iNOS↓, 2,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 1,   MAPK↑, 2,   Mcl-1↓, 2,   p38↑, 2,   Pyro↑, 1,   survivin↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   other∅, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↑, 1,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 5,   GRP78/BiP↑, 1,   HSP90↓, 2,   NQO2↑, 1,   PERK↑, 2,   UPR↑, 3,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   DNAdam↑, 3,   P53↑, 4,   p‑P53↑, 1,   PARP↑, 2,   cl‑PARP↑, 4,   PCNA↓, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 5,   CDK4↓, 3,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 7,   cycE/CCNE↓, 1,   P21↑, 3,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

AR-V7?, 1,   CD44↓, 1,   cFos↓, 1,   CSCs↓, 1,   EMT↓, 7,   EMT↝, 1,   ERK↓, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 2,   HDAC8↓, 2,   Let-7↑, 1,   mTOR↓, 6,   Nanog↓, 1,   NOTCH1↑, 3,   OCT4↓, 1,   PI3K↓, 7,   PI3K↑, 1,   PTEN↓, 1,   SCF↓, 2,   SHP1↑, 1,   SOX2↓, 1,   STAT3↓, 5,   STAT3↑, 1,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT4↑, 1,   TOP1↓, 3,   TumCG↓, 10,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 4,   CDKN1C/p57↑, 1,   CLDN1↓, 2,   E-cadherin↑, 5,   FAK↓, 2,   p‑FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   MMP-10↓, 1,   MMP2↓, 3,   MMP9↓, 7,   MMP9↑, 1,   N-cadherin↓, 2,   PDGF↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 1,   SPARC↑, 1,   TET1↑, 3,   TumCI↓, 10,   TumCMig↓, 8,   TumCP↓, 17,   TumMeta↓, 6,   TumMeta↑, 1,   Twist↓, 3,   uPA↓, 1,   VCAM-1↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 11,   ATF4↑, 2,   EGFR↓, 1,   Hif1a↓, 5,   VEGF↓, 9,   VEGFR2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↑, 1,   COX2↓, 7,   COX2↑, 1,   CXCR4↓, 1,   DCells↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IKKα↓, 2,   IL10↓, 1,   IL12↑, 1,   IL15↑, 1,   IL1β↓, 5,   IL2↑, 1,   IL6↓, 5,   IL8↓, 2,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 7,   MCP1↓, 1,   NF-kB↓, 25,   NF-kB↑, 3,   NK cell↑, 1,   p65↓, 1,   PD-L1↓, 1,   PGE2↓, 2,   TLR4↓, 3,   TLR4↝, 1,   TNF-α↓, 7,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,   NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CYP19?, 1,   CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 5,   BioAv↝, 2,   ChemoSen↑, 8,   Dose↝, 3,   eff↑, 16,   Half-Life↓, 1,   Half-Life↝, 1,   RadioS↑, 1,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 2,   BRCA1↓, 1,   EGFR↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 5,   Ki-67↓, 1,   LDH↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiDiabetic↑, 1,   AntiTum↑, 4,   cardioP↑, 2,   CardioT↑, 1,   chemoP↑, 2,   chemoPv↑, 3,   cognitive↑, 1,   hepatoP↓, 1,   hepatoP↑, 1,   neuroP↑, 4,   OS↑, 3,   RenoP↑, 1,   toxicity↓, 1,   toxicity↑, 1,   TumVol↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 237

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Dysb↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 17,   Catalase↓, 1,   Catalase↑, 8,   Ferroptosis↓, 1,   GPx↓, 1,   GPx↑, 6,   GSH↑, 7,   GSR↑, 1,   GSTs↑, 2,   HDL↑, 2,   HO-1↓, 1,   HO-1↑, 7,   Keap1↓, 1,   lipid-P↓, 7,   MDA↓, 7,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 12,   ROS↓, 22,   SOD↑, 11,   SOD1↑, 1,   TAC↑, 1,   TBARS↓, 1,   Thiols↑, 1,   VitC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MEK↓, 1,   MMP↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   cAMP↑, 1,   glucose↓, 1,   glucose↑, 1,   glucose↝, 1,   GLUT2↑, 1,   HMG-CoA↓, 1,   LDH↓, 2,   lipidLev↓, 2,   NADPH↓, 1,   NADPH↑, 1,   PPARα↑, 1,   PPARα↝, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 3,   BAX↓, 2,   Bcl-2↑, 1,   Casp↓, 1,   Casp3↓, 3,   Casp9↓, 2,   Fas↓, 1,   Ferroptosis↓, 1,   HGF/c-Met↑, 1,   iNOS↓, 7,   JNK↓, 3,   MAPK↓, 5,   MCT1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 1,   other↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP↓, 1,   CHOP↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   DNMT1↓, 1,   PCNA↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↑, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   miR-34a↓, 1,   PI3K↓, 1,   PTEN↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 3,   Ca+2↓, 1,   MMP9↑, 1,   MMPs↓, 1,   MMPs↑, 1,   SMAD3↓, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TRPC1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 4,   TXA2↓, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   IBI↑, 1,   OCLN↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 11,   IFN-γ↓, 1,   IL1↓, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 7,   IL2↓, 1,   IL6↓, 3,   Imm↑, 1,   Inflam↓, 21,   NF-kB↓, 27,   PGE2↓, 1,   TLR1↓, 1,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 10,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 3,   BDNF∅, 1,   MAOA↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   BACE↓, 1,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↓, 1,   GR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 11,   BioAv⇅, 1,   BioAv↝, 4,   Dose↝, 1,   eff↑, 4,   P450↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 2,   BP↓, 3,   GutMicro↑, 3,   IL6↓, 3,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 3,   AntiTum↑, 1,   cardioP↑, 13,   cardioP⇅, 1,   chemoPv↑, 4,   cognitive↑, 4,   hepatoP↑, 12,   memory↑, 7,   neuroP↑, 14,   Obesity↓, 4,   RenoP↑, 4,   Risk↓, 1,   toxicity↓, 2,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 3,  
Total Targets: 149

Scientific Paper Hit Count for: NF-kB, Nuclear factor kappa B
71 Curcumin
43 Thymoquinone
28 Resveratrol
24 Propolis -bee glue
22 Quercetin
22 Lycopene
21 EGCG (Epigallocatechin Gallate)
20 Betulinic acid
20 Fisetin
19 Baicalein
19 Silymarin (Milk Thistle) silibinin
18 Sulforaphane (mainly Broccoli)
16 Ashwagandha(Withaferin A)
15 Alpha-Lipoic-Acid
15 Apigenin (mainly Parsley)
14 Eugenol
14 Shikonin
13 Boswellia (frankincense)
12 Silver-NanoParticles
12 Artemisinin
12 Chrysin
11 Cisplatin
11 Berberine
11 Caffeic Acid Phenethyl Ester (CAPE)
11 Honokiol
11 Rosmarinic acid
10 Beta-Caryophyllene
10 Luteolin
9 Magnetic Fields
9 Radiotherapy/Radiation
9 Garcinol
8 Capsaicin
8 Chlorogenic acid
8 Crocetin
8 Disulfiram
8 Hydrogen Gas
8 Phenethyl isothiocyanate
7 Selenite (Sodium)
7 Allicin (mainly Garlic)
7 Caffeic acid
7 Nimbolide
7 Parthenolide
7 Pterostilbene
7 Vitamin K2
6 Deguelin
6 Dandelion Root
6 Copper and Cu NanoParticles
6 Magnolol
5 Anethole/trans-Anethole
5 Boron
5 Celastrol
5 Cinnamon
5 Ellagic acid
5 Piperine
5 Graviola
5 Piperlongumine
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Astaxanthin
4 Docetaxel
4 Berbamine
4 borneol
4 Chemotherapy
4 Hydroxycinnamic-acid
4 Ursolic acid
4 Emodin
3 1,8-Cineole
3 Auranofin
3 Astragalus
3 Citric Acid
3 Gemcitabine (Gemzar)
3 beta-glucans
3 xanthohumol
3 Bromelain
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Carnosic acid
3 Carvacrol
3 Cat’s Claw
3 Celecoxib
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Cucurbitacin
3 Ginger/6-Shogaol/Gingerol
3 Docosahexaenoic Acid
3 eicosapentaenoic acid
3 Ferulic acid
3 Gambogic Acid
3 Geraniol
3 Orlistat
3 HydroxyTyrosol
3 Oleuropein
3 Rutin
3 Sulfasalazine
2 Ajoene (compound of Garlic)
2 5-fluorouracil
2 immunotherapy
2 Baicalin
2 Biochanin A
2 Brucea javanica
2 brusatol
2 Zinc
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorophyllin
2 Echinacea
2 Photodynamic Therapy
2 CUSP9
2 D-limonene
2 Eurycomanone
2 Paclitaxel
2 Proanthocyanidins
2 Melatonin
2 Methyl salicylate / Sweet Birch oil
2 Methylsulfonylmethane
2 Naringin
2 Niclosamide (Niclocide)
2 Phenylbutyrate
2 Plumbagin
2 Psoralidin
2 salinomycin
2 Selenium NanoParticles
2 Aflavin-3,3′-digallate
1 2-DeoxyGlucose
1 Anthocyanins
1 alpha Linolenic acid
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Arctigenin
1 Aloe anthraquinones
1 Cannabidiol
1 Bufalin/Huachansu
1 Bacopa monnieri
1 Selenium
1 Bruteridin(bergamot juice)
1 Carnosine
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chitosan
1 Carvone
1 Lecithin
1 Oxygen, Hyperbaric
1 Galantamine
1 methylseleninic acid
1 Cyclopamine
1 Diclofenac
1 Dipyridamole
1 Evodiamine
1 Ascorbyl Palmitate
1 Genistein (soy isoflavone)
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Grapeseed extract
1 HydroxyCitric Acid
1 Juglone
1 Magnetic Field Rotating
1 Moringa oleifera
1 Mushroom Chaga
1 Neem
1 Oroxylin A
1 Propyl gallate
1 temozolomide
1 Kaempferol
1 Perilla
1 Salvia officinalis
1 Sanguinarine
1 Sesame seeds and Oil
1 Taurine
1 Tomatine
1 Turmerones
1 Thymol-Thymus vulgaris
1 Vitamin B1/Thiamine
1 Vitamin D3
1 probiotics
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:214  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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