NRF2 Cancer Research Results

NRF2, nuclear factor erythroid 2-related factor 2: Click to Expand ⟱
Source: TCGA
Type: Antiapoptotic
Nrf2 is responsible for regulating an extensive panel of antioxidant enzymes involved in the detoxification and elimination of oxidative stress. Thought of as "Master Regulator" of antioxidant response.
-One way to estimate Nrf2 induction is through the expression of NQO1.
NQO1, the most potent inducer:
SFN 0.2 μM,
quercetin (2.5 μM),
curcumin (2.7 μM),
Silymarin (3.6 μM),
tamoxifen (5.9 μM),
genistein (6.2 μM ),
beta-carotene (7.2μM),
lutein (17 μM),
resveratrol (21 μM),
indol-3-carbinol (50 μM),
chlorophyll (250 μM),
alpha-cryptoxanthin (1.8 mM),
and zeaxanthin (2.2 mM)

1. Raising Nrf2 enhances the cell's antioxidant defenses and ↓ROS. This strategy is used to decrease chemo-radio side effects.
2. Downregulating Nrf2 lowers antioxidant defenses and ↑ROS. In cancer cells this leads to DNA damage, and cell death.
3. However there are some cases where increasing Nrf2 paradoxically causes an increase in ROS (cancer cells). Such as cases of Mitochondial overload, signal crosstalk, reductive stress

-In some cases, Nrf2 is overexpressed in cancer cells, which can lead to the activation of genes involved in cell proliferation, angiogenesis, and metastasis. This can contribute to the development of resistance to chemotherapy and targeted therapies.
-Increased Nrf2 expression: Lung, Breast, Colorectal, Prostrate.
Decreased Nrf2 expression: Skine, Liver, Pancreatic.
-Nrf2 is a cytoprotective transcription factor which demonstrated both a negative effect as well as a positive effect on cancer
- "promotes Nrf2 translocation from the cytoplasm to the nucleus," means facilitates the movement of Nrf2 into the nucleus, thereby enhancing the cell's antioxidant and cytoprotective responses. -Major regulator of Nrf2 activity in cells is the cytosolic inhibitor Keap1.

Nrf2 Inhibitors and Activators
Nrf2 Inhibitors: Brusatol, Luteolin, Trigonelline, VitC, Retinoic acid, Chrysin
Nrf2 Activators: SFN, OPZ EGCG, Resveratrol, DATS, CUR, CDDO, Api
- potent Nrf2 inducers from plants include sulforaphane, curcumin, EGCG, resveratrol, caffeic acid phenethyl ester, wasabi, cafestol and kahweol (coffee), cinnamon, ginger, garlic, lycopene, rosemany

Nrf2 plays dual roles in that it can protect normal tissues against oxidative damage and can act as an oncogenic protein in tumor tissue.
– In healthy tissues, NRF2 activation helps protect cells from oxidative damage and maintains cellular homeostasis.
– In many cancers, constitutive activation of NRF2 (often through mutations in NRF2 itself or loss-of-function mutations in KEAP1) leads to an enhanced antioxidant capacity.
– This upregulation can promote tumor cell survival by enabling cancer cells to thrive under oxidative stress, resist chemotherapeutic agents, and sustain metabolic reprogramming.
– Elevated NRF2 levels have been implicated in promoting tumor growth, metastasis, and resistance to therapy in various malignancies.
– High or sustained NRF2 activity is frequently associated with aggressive tumor phenotypes, poorer prognosis, and decreased overall survival in several cancer types.
– While its activation is essential for protecting normal cells from oxidative stress, aberrant or sustained NRF2 activation in tumor cells can lead to enhanced survival, therapeutic resistance, and tumor progression.

NRF2 inhibitors: (to decrease antioxidant defenses and increase cell death from ROS).
-Brusatol: most cited natural inhibitors of Nrf2.
-Luteolin: luteolin can reduce Nrf2 activity in specific cancer models and may enhance cell sensitivity to chemotherapy. However, luteolin is also known as an antioxidant, and its influence on Nrf2 can sometimes be context dependent.
-Apigenin: certain studies to down‑regulate Nrf2 in cancer cells: Dose and context dependent .
-Oridonin:
-Wogonin: although its effects might be cell‑ and dose‑specific.
- Withaferin A

Scientific Papers found: Click to Expand⟱
5228- EMD,    Evaluating anticancer activity of emodin by enhancing antioxidant activities and affecting PKC/ADAMTS4 pathway in thioacetamide-induced hepatocellular carcinoma in rats
- in-vivo, HCC, NA
OS↑, PKCδ↓, ERK5↓, MMP3↓, VEGF↓, NRF2↑, HO-1↑, MDA↓, AFP↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6828- EMD,    Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice
- in-vitro, AD, U251
*MMP↑, *ROS↓, *NRF2↑, *HO-1↑, *SOD↑, *Bcl-2↑, *Catalase↑, *BAX↓, *memory↑, *ANXi↓, *Aβ↓, *antiOx↑, *MDA↓,
6356- Eug,  Cin,    Investigating the Molecular Mechanisms of the Anticancer Effects of Eugenol and Cinnamaldehyde Against Colorectal Cancer (CRC) Cells In Vitro
- in-vitro, CRC, SW-620 - in-vitro, CRC, Caco-2 - in-vitro, Nor, NCM460
P21↑, ChemoSen↑, Casp3↑, IL4↓, IL8↓, ROS↑, NRF2↑, HO-1↑, EMT↓,
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,
6886- FA,  MTX,    Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats
- in-vivo, Nor, NA
*hepatoP↑, *ROS↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *p65↓, *BAX↓, *Casp3↓, *NRF2↑, *HO-1↑, *PPARγ↑, *Inflam↓,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
3778- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review
- Review, AD, NA
*neuroP↑, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK?, *hepatoP↑, *TLR4↓, *PPARγ↑, *NRF2↑, *Fenton↓, *IronCh↑, *MDA↓, *HO-1↑, *Bil↑, *GCLC↑, *GCLM↑, *NQO1↑, *GutMicro↑, *SOD↑, *Ca+2↓, *lipid-P↓, *PGE2↓,
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
6907- FIS,    Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors
- in-vitro, AD, NA
*p‑tau↓, *NRF2↑, *mTORC1↓, *neuroP↑, *memory↑, *Inflam↓, *memory↑, *TFEB↑, *mTOR↓,
6922- FIS,    Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin
- Review, Var, NA
*memory↑, *Inflam↓, *5LO↓, *lipid-P↓, *NF-kB↓, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, *ROS↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumCMig↓, MMPs↓, PSA↓,
2852- FIS,    A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
- Review, CRC, NA
Risk↓, P53↑, MDM2↓, COX2/PTGS2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,
2858- FIS,    Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines
- in-vitro, BC, 4T1
HO-1↑, NRF2↑, MMP2↓, MMP9↓,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2/PTGS2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, Synergy↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2/PTGS2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, Synergy↑, Synergy↑, Synergy↑, RadioS↑, ChemoSen↑, Half-Life↝,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1/ATG6↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2/KDR/Flk1↓, IAP2/BIRC3↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2829- FIS,    Fisetin: An anticancer perspective
- Review, Var, NA
TumCP↓, TumCI↓, TumCCA↑, TumCG↓, Apoptosis↑, cl‑PARP↑, PKCδ↓, ROS↓, ERK↓, NF-kB↓, survivin↓, ROS↑, PI3K↓, Akt↓, mTOR↓, MAPK↓, p38↓, HER2/EBBR2↓, EMT↓, PTEN↑, HO-1↑, NRF2↑, MMP2↓, MMP9↓, MMP↓, Casp8↑, Casp9↑, TRAILR↑, Cyt‑c↑, XIAP↓, P53↑, CDK2↓, CDK4↓, CDC25↓, CDC2↓, VEGF↓, DNAdam↑, TET1↓, CHOP/DDIT3↑, CD44↓, CD133↓, uPA↓, CSCs↓,
2830- FIS,    Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent
- Review, Var, NA
TumCG↓, angioG↓, *ROS↓, TumCMig↓, VEGF↓, MAPK↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, NRF2↑, HO-1↑, ROS↓, Inflam↓, ER Stress↑, ROS↑, TumCP↓, ChemoSen↑, PTEN↑, P53↑, Casp3↑, Casp8↑, Casp9↑, COX2/PTGS2↓, Wnt↓, EGFR↓, Mcl-1↓, survivin↓, IAP1↓, IAP2/BIRC3↓, PGE2↓, β-catenin/ZEB1↓, DR5↑, MMP2↓, MMP9↓, FAK↓, uPA↓, EMT↓, ERK↓, JNK↑, p38↑, PKCδ↓, BioAv↓, BioAv↑, BioAv↑,
2833- FIS,  AgNPs,    Glucose-capped fisetin silver nanoparticles induced cytotoxicity and ferroptosis in breast cancer cells: A molecular perspective
- in-vitro, BC, MDA-MB-231
MMP↓, ROS↑, NRF2↑, NOX↑, selectivity↑,
2838- FIS,    Fisetin induces apoptosis in colorectal cancer cells by suppressing autophagy and down-regulating nuclear factor erythroid 2-related factor 2 (Nrf2)
- in-vitro, CRC, NA
cl‑Casp3↑, cl‑PARP↑, MMP↓, Cyt‑c↑, ROS↑, NRF2↓,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
7012- Fuc,    Fucoidan: A promising natural therapeutic agent for protecting human kidney health
- Review, EC, NA
*RenoP↑, *Inflam↓, *antiOx↑, *ROS↓, *BloodF↑, *diuretic↑, *BioAv↓, *BioAv↑, *MAPK↓, *ERK↑, *NLRP3↓, *NRF2↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *lipid-P↓, *DNAdam↓, *Fibrosis↓, *JAK2↓, *STAT3↓, *uricA↓, *COL1↓, *α-SMA↓, *SIRT1↑, *HO-1↑, *GLP-1R↑, *HMGB1↓, *RAGE↓, *NF-kB↓, *TGF-β1↓, *PI3K↓, *Akt↓, *GutMicro↑, *SCFAs↑, *Buty↑, *IBI↑, *TJ↑, *Dose↝,
4029- FulvicA,  Chemo,    Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2/Keap-1 signaling
- in-vivo, Var, NA
*other↑, *PCNA↑, *SOD↑, *lipid-P↓, *NRF2↑, *Keap1↓, *chemoP↑,
7034- GA,  RES,    The Growth Inhibitory Effect of Resveratrol and Gallic Acid on Prostate Cancer Cell Lines through the Alteration of Oxidative Stress Balance: The Interplay between Nrf2, HO-1, and BACH1 Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TumCG↓, ROS↓, SOD↑, GPx↑, Catalase↑, GSR↑, GSH↑, HO-1↑, NRF2↑,
7040- GA,    Effects of gallic acid on acrylamide-induced endoplasmic reticulum stress, neuroinflammation and neuronal apoptosis in rats
- Trial, AD, NA
*SOD↑, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TNF-α↓, *IL1β↓, *BAX↓, *Casp3↓, *BDNF↑, *NRF2↑, *HO-1↑,
7215- GBE,  Cisplatin,    Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer
- vitro+vivo, NSCLC, NA
AntiCan↑, TumAuto↑, ChemoSen↑, Iron↑, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, ROS↑, NRF2↓, HO-1↓, MMP↓,
1188- GBE,    The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2-mediated antioxidant protection
- Review, Stroke, NA
*NRF2↑, *ROS↓, *Stroke↓,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓, *antiAll↑,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,
7141- GI,    Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability
- Study, Nor, BV2
*eff↑, *CompStab↓, *NRF2↑, *Inflam↓, *eff↑, *antiOx↑, *neuroP↑, *COX2/PTGS2↓, *NF-kB↓, *eff↓, *BioAv↝, *CompStab↑,
7156- GI,    Ginger-derived nanoparticles protect against alcohol-induced liver damage
- in-vivo, Nor, NA
*hepatoP↑, *NRF2↑, *ROS↑,
7242- Gink,  Cisplatin,    Ginkgetin reverses cisplatin resistance in cervical cancer by regulating the Nrf2/HO-1 signaling pathway to induce ferroptosis
- in-vitro, Cerv, HeLa
TumCP↓, NRF2↓, ROS↑, i-Iron↑, GSH↓, SOD↓, Catalase↓, lipid-P↑, ACSL4↑, NO↓, GPx4↓, Ferroptosis↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
7251- Gink,    Ginkgetin: A Promising Multitarget Agent for Diverse Diseases
- Review, Var, NA
*Inflam↓, *antiOx↓, AntiCan↑, *neuroP↑, *cardioP↑, *Bacteria↓, *ROS↓, *lipid-P↓, *NRF2↓, *Keap1↓, *NF-kB↓, *MAPK↓, MMP2↓, M2 MC↓, JAK2↓, STAT3↓, TumCP↓, Casp↑, ChemoSen↑, *BMD↑, *Aβ↓, *Stroke↓, *BioAv↓,
7296- Gins,    Korean Red Ginseng Marc-Derived Gintonin Improves Alzheimer's Cognitive Dysfunction by Upregulating LPAR1
- vitro+vivo, AD, SH-SY5Y
*MAPK↓, *NF-kB↓, *STAT3↓, *ROS↓, *NRF2↑, *HO-1↑, *HNE↑, *LPAR1/EDG2↑, *cognitive↑,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE/β-secretase↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
7484- H2,    Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer's Disease Models
- in-vivo, AD, NA
*Dose↝, *cognitive↑, *ROS↓, *Inflam↓, *neuroP↑, *memory↑, *Catalase↑, *TNF-α↓, *Aβ↓, *GABA↓, *H2O2↓, *GFAP↓, *antiOx↑, *NRF2↑,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,
7926- H2,    Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model
- in-vivo, Asthma, NA
*Dose↝, *Airway↓, *BALF-Infl↓, *Th2↓, *IL4↓, *IgE↓, *MDA↓, *SOD↑, *NF-kB↓, *NRF2↑, *antiAll↑,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *BP∅, *BBB↑,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
3761- H2,    Therapeutic Inhalation of Hydrogen Gas for Alzheimer's Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
- Human, AD, NA
*cognitive↑, *BBB↑, *ROS↓, *NRF2↑, *Inflam↓, *NFAT↓, *FAO↓, *4-HNE↓, *PGC-1α↑, *Ferroptosis↓,
2521- H2,    Oxyhydrogen Gas: A Promising Therapeutic Approach for Lung, Breast and Colorectal Cancer
- Review, CRC, NA - Review, Lung, NA - Review, BC, NA
Inflam↑, ROS↓, ChemoSen↑, p‑PI3K↓, p‑Akt↓, QoL↑, GutMicro↑, chemoP↑, radioP↑, *NRF2↑, *Catalase↑, *GPx↑, *HO-1↑, *SOD↑, *TNF-α↓, *IL4↓, *IL6↓, ChemoSen↑, Appetite↑, cognitive↑, Pain↓, Sleep↑, other?,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, Synergy↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,

Showing Research Papers: 251 to 300 of 687
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 687

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 9,   ARE↓, 1,   ARE↑, 2,   ARE/EpRE↑, 1,   Catalase↓, 13,   Catalase↑, 11,   Copper↑, 1,   Fenton↑, 5,   frataxin↑, 1,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 4,   GPx↑, 7,   GPx1↓, 2,   GPx1⇅, 1,   GPx4↓, 30,   GSH↓, 47,   GSH↑, 12,   i-GSH↓, 1,   GSH/GSSG↓, 5,   GSR↓, 2,   GSR↑, 3,   GSS↑, 1,   GSSG↑, 3,   GSTs↓, 2,   GSTs↑, 5,   GSTs↝, 1,   H2O2↓, 3,   H2O2↑, 4,   HO-1↓, 33,   HO-1↑, 51,   HO-1⇅, 1,   Iron↓, 1,   Iron↑, 19,   i-Iron↓, 1,   i-Iron↑, 3,   Keap1↓, 6,   Keap1↑, 4,   Keap1↝, 2,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↓, 1,   lipid-P↑, 23,   MDA↓, 5,   MDA↑, 20,   i-MDA↑, 1,   MPO↓, 2,   NADH↓, 1,   NFE2L2↑, 1,   NOX↓, 1,   NOX↑, 1,   NOX4↓, 1,   NOX4↑, 2,   NQO1↓, 8,   NQO1↑, 16,   NRF2↓, 119,   NRF2↑, 129,   NRF2⇅, 4,   NRF2↝, 7,   NRF2∅, 3,   p‑NRF2↓, 2,   p‑NRF2↑, 2,   Prx↓, 1,   Prx↑, 1,   Prx4↑, 1,   PrxI↓, 1,   RNS↓, 1,   ROS?, 2,   ROS↓, 40,   ROS↑, 204,   ROS⇅, 5,   ROS↝, 2,   ROS∅, 2,   i-ROS↑, 1,   mt-ROS↓, 1,   mt-ROS↑, 2,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 11,   SOD↑, 15,   SOD1↓, 1,   SOD1↑, 4,   SOD2↓, 8,   SOD2↑, 3,   T-SOD↓, 1,   Trx↓, 3,   Trx↑, 3,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 7,   TrxR↑, 1,   TrxR1↓, 3,   TrxR1↑, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 9,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↓, 2,   FTH1↑, 1,   FTL↑, 1,   IronCh↑, 1,   Mets↑, 1,   NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 5,   CDC25↓, 5,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   EGF↓, 2,   ETC↓, 5,   MFN2↑, 1,   mitResp↓, 2,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↑, 14,   OCR↓, 1,   OCR↑, 1,   OXPHOS↓, 4,   OXPHOS↑, 1,   mt-OXPHOS↓, 1,   PDH↓, 1,   PGC-1α↑, 1,   SDH↓, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 1,   ACC-α↓, 1,   ACC1↓, 2,   ACLY↓, 2,   ACSL4↑, 2,   ALAT↓, 3,   AMPK↑, 17,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 12,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 2,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 5,   G6PD↓, 1,   GLS↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 7,   GlutMet↓, 2,   Glycolysis↓, 24,   GSK‐3β↓, 8,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 4,   H2S↑, 1,   HK2↓, 13,   lactateProd↓, 6,   lactateProd↑, 1,   LDHA↓, 5,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 4,   NADPH↑, 6,   PCK1↓, 1,   PDK1 / PDPK1↓, 7,   PDK3↑, 1,   PFK↓, 1,   PKM2↓, 5,   PKM2↑, 1,   PPP↑, 1,   Pyruv↓, 1,   SCD1↓, 2,   SIRT1↓, 3,   SIRT1↑, 6,   SLC1A5↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 4,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 3,   Apoptosis?, 2,   Apoptosis↓, 3,   Apoptosis↑, 123,   Apoptosis↝, 1,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 1,   p‑ASK1↑, 1,   BAD↑, 3,   Bak↑, 3,   BAX↓, 4,   BAX↑, 63,   BAX↝, 2,   Bax:Bcl2↑, 13,   Bcl-2↓, 61,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 11,   Bcl-xL↝, 1,   BID↑, 4,   BIM↑, 6,   BNIP3↑, 2,   Casp↑, 20,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   cl‑Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 3,   Casp3↓, 2,   Casp3↑, 66,   Casp3↝, 1,   cl‑Casp3↑, 12,   cl‑Casp3⇅, 1,   proCasp3↑, 3,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 16,   Casp8∅, 2,   cl‑Casp8↑, 1,   proCasp8↑, 1,   Casp9↑, 44,   cl‑Casp9↑, 9,   proCasp9↓, 1,   proCasp9↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 55,   Cyt‑c↝, 1,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 20,   Fas↑, 11,   FasL↑, 5,   Ferroptosis↑, 38,   GranB/GZMB↝, 1,   GSDMD↑, 2,   GSDME-N↑, 1,   HEY1↓, 1,   IAP1↓, 4,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   ICAD↑, 1,   iNOS↓, 12,   Mcl-1?, 1,   Mcl-1↓, 8,   Mcl-1↑, 1,   MDM2↓, 8,   p‑MDM2↓, 1,   MOMP↑, 4,   Necroptosis↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p38↓, 5,   p38↑, 11,   p‑p38↓, 2,   p‑p38↑, 3,   Perforin↝, 1,   PUMA↑, 2,   Pyro↑, 4,   RIP3↑, 1,   survivin↓, 27,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 1,   TumCD↑, 8,   XIAP↓, 16,   XIAP↑, 1,   YAP/TEAD↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 93,   Akt↑, 3,   Akt↝, 2,   p‑Akt↓, 24,   p‑Akt↑, 1,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 1,   BRAF↝, 1,   p‑CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   p‑cMET↑, 1,   p‑CREB↑, 1,   EF-1α↓, 1,   EGFR↓, 27,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 22,   ERK↑, 6,   p‑ERK↓, 4,   p‑ERK↑, 3,   ERK5↓, 1,   FGFR1↓, 1,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↝, 1,   HRAS↓, 1,   IKKα↓, 5,   IR↓, 1,   IκB↓, 2,   JAK↓, 3,   JAK↝, 1,   JAK1↓, 2,   JAK2↓, 6,   JNK↓, 2,   JNK↑, 14,   JNK↝, 1,   p‑JNK↑, 4,   MAP2K1/MEK1↓, 1,   MAPK↓, 16,   MAPK↑, 17,   MAPK↝, 3,   p‑MAPK↑, 2,   MARK4↓, 1,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 58,   mTOR↑, 1,   mTOR↝, 3,   p‑mTOR↓, 7,   p‑mTOR↑, 1,   mTORC2↓, 1,   p70S6↓, 2,   P70S6K↓, 4,   P70S6K↑, 1,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PAK↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 73,   PI3K↑, 4,   PI3K↝, 3,   p‑PI3K↓, 6,   p‑PI3K↑, 1,   PI3K/Akt↓, 1,   PI3K/Akt↝, 1,   PKCδ↓, 6,   PKCδ↑, 1,   PTEN↓, 3,   PTEN↑, 15,   PTEN↝, 2,   Raf↓, 2,   c-Raf↓, 1,   RAS↓, 7,   RAS↑, 1,   RET↓, 1,   RIP1↓, 1,   RIP1↑, 1,   SHP1↑, 1,   Sp1/3/4↓, 10,   Src↓, 1,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 53,   STAT3↑, 1,   p‑STAT3↓, 6,   STAT4↓, 1,   STAT5↓, 1,   STAT6↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 9,   ATF4↝, 1,   ATFs↑, 1,   cJun↓, 4,   cJun↑, 1,   cMyc↓, 24,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 4,   DNMT3B↓, 1,   DNMTs↓, 11,   EZH2↓, 1,   FOXM1↓, 2,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 5,   p‑FOXO3↓, 3,   FOXO4↓, 1,   H3↓, 1,   H3↑, 2,   p‑H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 2,   H4↓, 1,   H4↑, 1,   ac‑H4↓, 1,   ac‑H4↑, 2,   HATs↓, 3,   HATs↑, 1,   HDAC↓, 29,   HDAC↑, 1,   HDAC1↓, 6,   HDAC2↓, 6,   HDAC3↓, 6,   HDAC4↓, 1,   HDAC6↓, 1,   HDAC8↓, 3,   HES1↓, 1,   HMTs↓, 1,   KLF4↓, 1,   miR-124-3p↓, 1,   miR-133a-3p↑, 1,   miR-140↑, 1,   miR-155↓, 2,   miR-19b↓, 1,   miR-200c↑, 2,   miR-206↑, 1,   miR-21↓, 1,   miR-21↑, 1,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-30a-5p↑, 1,   miR-34a↓, 1,   miR-34a↑, 3,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-590-3p↑, 1,   Myc↓, 2,   OCT4↓, 11,   other?, 1,   other↓, 3,   other↑, 5,   other⇅, 1,   other↝, 9,   PhotoS↑, 1,   RUNX2↓, 1,   SOX2↓, 8,   SOX4↓, 2,   SOX4↑, 1,   SOX9↓, 2,   TET3↑, 1,   tumCV?, 1,   tumCV↓, 32,   USF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 4,   CHOP/DDIT3↑, 22,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 5,   p‑eIF2α↑, 4,   ER Stress↑, 37,   GRP78/BiP↑, 9,   GRP94↑, 1,   HSP27↓, 4,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 11,   ac‑HSP90↑, 1,   HSPs↑, 1,   IRE1↑, 2,   NQO2↑, 1,   PERK↑, 7,   p‑PERK↑, 1,   UPR↑, 10,   XBP-1↓, 2,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 9,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 1,   LC3B-II↑, 2,   LC3II↑, 3,   LC3s↑, 1,   p62↓, 6,   p62↑, 3,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 20,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   ATM↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 3,   DNAdam↑, 28,   DNAdam⇅, 1,   DNArepair↓, 1,   m-FAM72A↓, 1,   FEN1↓, 1,   hTERT/TERT↓, 10,   MGMT↓, 1,   P53?, 1,   P53↓, 4,   P53↑, 62,   P53↝, 3,   p‑P53↑, 3,   PARP↓, 4,   PARP↑, 10,   cl‑PARP↓, 2,   cl‑PARP↑, 37,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 18,   POLD1↓, 1,   SIRT6↓, 2,   Telomerase↓, 8,   TOP1↓, 2,   TOP2↓, 3,   γH2AX↑, 2,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 14,   CDK1↑, 4,   CDK2↓, 28,   CDK2↑, 2,   CDK4↓, 28,   CDK6↓, 10,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 2,   CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 1,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 7,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 14,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 40,   cycD1/CCND1↑, 2,   cycD1/CCND1↝, 1,   CycD3↓, 1,   CycD3↑, 1,   cycE/CCNE↓, 12,   cycE/CCNE↑, 2,   Ki-67↓, 15,   mitA↑, 1,   p19↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 44,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 16,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 112,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 2,   ALDH1A1↓, 2,   BMI1↓, 2,   BMP7/OP1↓, 1,   BMPs↑, 3,   CD133↓, 4,   CD133↑, 1,   CD34↓, 1,   cFos↓, 4,   cFos↑, 1,   cMYB↓, 2,   CSCs?, 1,   CSCs↓, 25,   Diff↑, 2,   EP4/PTGER4↑, 1,   FGF↓, 2,   Gli↓, 2,   Gli1↓, 4,   HH↓, 3,   IGF-1?, 1,   IGF-1↓, 6,   IGFBP3↑, 1,   Ki-67↓, 15,   Let-7↑, 1,   mTORC1↓, 4,   Nanog↓, 10,   Nestin↓, 2,   NICD↓, 1,   NOTCH↓, 10,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↑, 3,   NOTCH2↑, 1,   NOTCH3↓, 2,   SCF↓, 1,   Shh↓, 5,   Smo↓, 3,   STAT1↓, 3,   TAZ↓, 1,   TumCG↓, 42,   TumCG↑, 1,   TumCP?, 1,   TumCP↓, 88,   TumCP↑, 4,   Wnt↓, 27,   Wnt↝, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   annexin II↓, 1,   AP-1↓, 9,   AP-1↑, 2,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 1,   BACH1↓, 1,   BACH1↑, 1,   Ca+2↓, 1,   Ca+2↑, 15,   Ca+2↝, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↑, 1,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 4,   E-cadherin↑, 26,   EMT↓, 52,   EMT↝, 1,   FAK↓, 12,   FAK↑, 1,   p‑FAK↓, 2,   Fibronectin↓, 3,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB3↓, 2,   KRAS↓, 2,   LAMs↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 3,   MET↑, 3,   p‑MET↓, 1,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 45,   MMP2↑, 1,   MMP2⇅, 1,   MMP2↝, 1,   MMP3↓, 7,   MMP7↓, 9,   MMP9↓, 51,   MMP9↑, 2,   MMP9⇅, 1,   MMPs↓, 22,   N-cadherin↓, 20,   NFAT↑, 1,   PDGF↓, 3,   Rac1↓, 1,   Rho↓, 3,   Rho↑, 1,   ROCK1↓, 6,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 7,   Smad1↓, 2,   Smad1↑, 2,   SMAD2↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   Snail?, 1,   Snail↓, 17,   TET1↓, 1,   TET1↑, 5,   TGF-β↓, 9,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↓, 3,   TIMP2↑, 2,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 2,   TumCI↓, 54,   TumCMig↓, 47,   TumMeta↓, 37,   TumMeta↑, 3,   TumPF↓, 1,   Twist↓, 13,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 18,   uPAR↓, 1,   Vim?, 1,   Vim↓, 24,   Vim↑, 1,   Zeb1↓, 7,   α-SMA↓, 1,   β-catenin/ZEB1↓, 31,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 56,   CD31/PECAM-1↓, 2,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 54,   LOX1↓, 1,   NO↓, 4,   NO↑, 1,   REL↑, 1,   VCAM-1↓, 1,   VEGF↓, 73,   VEGF↑, 1,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   CLDN1↓, 3,   CX43/GJA1↓, 1,   EPR↑, 1,   GLUT1↓, 6,   GLUT4↓, 1,   MMP↓, 60,   MMP↑, 2,   MPT↑, 1,   TRPV1↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD25+↑, 1,   CD4+↑, 1,   CD44↓, 8,   CD47↓, 1,   CD8+↑, 3,   cDC2↓, 2,   COX1↓, 2,   COX2/PTGS2↓, 45,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCR2↓, 1,   CXCR3↓, 1,   CXCR4↓, 6,   DR4↑, 6,   Eos↑, 1,   FOXP3↑, 2,   Gal-3↓, 1,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 8,   IFN-γ↓, 4,   IFN-γ↑, 1,   IL1↓, 6,   IL10↓, 2,   IL10↑, 1,   IL12↓, 2,   IL18↓, 1,   IL1β↓, 13,   IL1β↑, 1,   IL2↓, 3,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL5↓, 1,   IL6↓, 31,   IL6↑, 1,   IL6↝, 1,   IL8↓, 10,   IL8↑, 1,   Imm↑, 6,   Imm↝, 2,   INF-γ↑, 1,   Inflam↓, 19,   Inflam↑, 1,   M1↓, 1,   M2 MC↓, 2,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   NAF1↓, 3,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 99,   NF-kB↑, 4,   NF-kB↝, 3,   p‑NF-kB↑, 1,   NK cell↑, 5,   NK cell⇅, 1,   NLRP3↓, 3,   NLRP3↑, 5,   p65↓, 5,   p‑p65↓, 2,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 13,   PSA↓, 7,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 2,   Th1 response↑, 2,   Th2↑, 1,   TLR1↑, 1,   TLR4↓, 4,   TLR4↝, 1,   TNF-α↓, 23,   TNF-α↑, 1,   TNF-α↝, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   GGT/CD224↑, 1,   pH↝, 1,   pH∅, 1,   e-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,   AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PRNP↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACTH↓, 1,   AhR↓, 2,   AhR↓, 1,   AR↓, 8,   AR↝, 1,   COMT↑, 1,   CYP19↓, 1,   ER-α36↓, 4,   ER(estro)↓, 1,   Estro↝, 1,   FGF21↓, 1,   GR↓, 1,   GR↑, 1,   PPARα↓, 1,   PPARγ↓, 3,   PPARγ↑, 4,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 26,   BioAv↑, 28,   BioAv↝, 9,   BioEnh?, 1,   BioEnh↑, 2,   chemoR↓, 1,   ChemoSen?, 1,   ChemoSen↓, 2,   ChemoSen↑, 118,   ChemoSen⇅, 1,   CYP1A1↓, 3,   CYP1A2↓, 1,   CYP1B1↓, 1,   CYP3A4↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 5,   Dose↝, 26,   Dose∅, 2,   eff↓, 24,   eff↑, 47,   eff↝, 8,   eff∅, 1,   GSTA1↓, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 9,   MDR1↓, 6,   MRP1/ABCC1↓, 4,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↑, 1,   P450↓, 3,   P450↝, 1,   RadioS↓, 2,   RadioS↑, 36,   selectivity?, 1,   selectivity↑, 45,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 76,   TET2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 3,   ALP↓, 2,   AR↓, 8,   AR↝, 1,   AST↓, 2,   BP↓, 1,   BRAF↝, 1,   CEA↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 27,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   Ferritin↑, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 10,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 31,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 2,   LDH↓, 2,   LDH↑, 1,   Myc↓, 2,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 9,   PSA↓, 7,   PSA↝, 1,   PSA∅, 1,   PSADT↑, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan?, 1,   AntiCan↓, 1,   AntiCan↑, 30,   AntiCan∅, 2,   antiNeop↑, 2,   AntiTum↑, 18,   Appetite↑, 1,   cachexia↓, 1,   cardioP↑, 7,   CardioT↓, 2,   chemoP↑, 31,   chemoPv↑, 15,   ChemoSideEff↓, 5,   cognitive↑, 3,   fatigue↓, 1,   hepatoP↑, 6,   memory↑, 1,   Mucositis↓, 1,   neuroP↑, 14,   NP/CIPN↓, 2,   OS↓, 1,   OS↑, 8,   Pain↓, 3,   PFS↑, 1,   QoL↑, 5,   radioP↑, 13,   Remission↑, 1,   RenoP↑, 9,   Risk↓, 12,   Risk↑, 1,   Sleep↑, 2,   toxicity↓, 11,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 8,   TumW↓, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 6,   GutMicro↝, 1,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 984

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 3,   antiOx?, 1,   antiOx↓, 6,   antiOx↑, 194,   ARE↓, 1,   ARE↑, 15,   ARE↝, 1,   Bil↓, 1,   Bil↑, 2,   Catalase↓, 1,   Catalase↑, 115,   Catalase↝, 1,   DUOX1↓, 1,   Fenton↓, 3,   GCLC↑, 6,   GCLC↝, 1,   GCLM↑, 5,   GCLM↝, 1,   GPx↓, 2,   GPx↑, 82,   GPx↝, 1,   GPx1↑, 3,   GPx4↓, 2,   GPx4↑, 12,   GPx4∅, 1,   GSH↓, 4,   GSH↑, 143,   GSH/GSSG↓, 1,   GSH/GSSG↑, 3,   GSR↓, 2,   GSR↑, 11,   GSS↑, 2,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 18,   H2O2↓, 11,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 2,   HNE↓, 1,   HNE↑, 1,   HO-1?, 2,   HO-1↓, 5,   HO-1↑, 208,   HO-1⇅, 1,   HO-1↝, 1,   HO-1∅, 1,   HO-2↓, 1,   hyperG↓, 1,   hyperG↝, 1,   Iron↓, 4,   Iron↝, 1,   i-Iron↓, 3,   Keap1↓, 23,   Keap1↑, 1,   Keap1↝, 2,   ox-Keap1↑, 1,   lipid-P↓, 81,   lipid-P↑, 4,   mt-lipid-P↓, 1,   MDA↓, 120,   MDA↑, 2,   MPO↓, 20,   MPO↑, 1,   NOX↓, 3,   NOX1↓, 1,   NOX2↓, 3,   NOX4↓, 7,   NQO1↑, 56,   NQO1↝, 2,   Nrf1↑, 3,   NRF2?, 1,   NRF2↓, 18,   NRF2↑, 440,   NRF2⇅, 1,   NRF2↝, 2,   NRF2∅, 2,   p‑NRF2↑, 2,   ONOO↓, 1,   Prx↑, 4,   RNS↓, 4,   ROS?, 1,   ROS↓, 324,   ROS↑, 11,   ROS⇅, 4,   ROS∅, 3,   i-ROS↑, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   selenoP↑, 1,   SOD?, 1,   SOD↓, 2,   SOD↑, 167,   SOD↝, 1,   SOD1↑, 11,   SOD2↓, 1,   SOD2↑, 7,   TAC↑, 25,   TBARS↓, 6,   Thiols↑, 1,   TOS↓, 1,   Trx↓, 1,   Trx↑, 7,   Trx1↑, 6,   TrxR↑, 3,   TrxR1↑, 3,   UCPs↑, 1,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↓, 1,   xCT/SLC7A11↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 2,   FTH1↓, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 16,   Mets↝, 1,   NCOA4↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 3,   EGF↓, 1,   FIS1↓, 1,   Insulin↑, 1,   MFN2↑, 2,   mitResp↑, 2,   mtDam↓, 17,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   PDH↑, 1,   PGC-1α↑, 9,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 2,   SIRT3↑, 4,   TFAM↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   3MST/MPST↑, 1,   5LO↓, 5,   ACC↓, 1,   Acetyl-CoA↑, 1,   ACSL4↓, 3,   ACSL4∅, 1,   ALAT↓, 32,   ALDOC↑, 1,   AMPK↓, 2,   AMPK↑, 26,   p‑AMPK↑, 3,   ATP↓, 1,   ATP↑, 15,   Buty↑, 1,   cAMP↑, 3,   CBS↑, 1,   CRM↑, 3,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FAO↓, 1,   FASN↓, 3,   G6PD↑, 2,   GAPDH↑, 1,   glucose↓, 4,   glucose↑, 2,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 6,   Glycolysis↑, 3,   GSK‐3β↓, 24,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 6,   H2S↑, 3,   HK2↓, 1,   HK2↑, 2,   HMG-CoA↓, 1,   LDHA↓, 1,   LDL↓, 12,   lipidLev↓, 1,   lipoGen↓, 1,   NAD↓, 1,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 11,   NADPH↑, 9,   NADPH∅, 1,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PKM2↓, 2,   PKM2↑, 1,   PONs↑, 1,   SCFAs↑, 2,   SIRT1↓, 2,   SIRT1↑, 24,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 4,   Apoptosis↓, 47,   Apoptosis↑, 2,   ASC↓, 1,   ASK1↓, 1,   BAX↓, 23,   BAX↑, 3,   Bax:Bcl2↓, 7,   Bcl-2↓, 4,   Bcl-2↑, 20,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 1,   Casp1↓, 4,   proCasp1↓, 1,   Casp12↓, 2,   Casp3?, 1,   Casp3↓, 39,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 9,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 12,   Casp9↑, 1,   Casp9∅, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 9,   Cyt‑c↑, 2,   Cyt‑c∅, 2,   Fas↓, 2,   Ferroptosis↓, 21,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 53,   iNOS↑, 2,   necrosis↓, 1,   p38↓, 5,   p38↑, 1,   p‑p38↓, 3,   Pyro↓, 2,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 29,   Akt↝, 1,   p‑Akt↑, 6,   e-Akt↑, 1,   AMPKα↑, 2,   CREB↑, 3,   p‑CREB↑, 3,   ERK↓, 11,   ERK↑, 10,   p‑ERK↓, 2,   p‑ERK↑, 3,   e-ERK↑, 1,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB?, 1,   IκB↑, 2,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 10,   JNK↑, 2,   p‑JNK↓, 6,   p‑JNK↑, 1,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 29,   MAPK↑, 4,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   Mst1↓, 1,   mTOR↓, 8,   mTOR↑, 5,   p‑mTOR↓, 3,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PFKFB2↓, 1,   PI3K↓, 6,   PI3K↑, 24,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↓, 2,   PKCδ↑, 3,   PP2A↑, 2,   PTEN↓, 3,   p‑PTEN↑, 1,   PTP1B↓, 1,   RIP1↓, 1,   STAT↓, 4,   STAT3↓, 8,   STAT3↑, 2,   STAT3↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF2↑, 1,   ATF4↓, 4,   ATF4↑, 1,   cJun↓, 3,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 2,   DNMTs↓, 1,   FOXO↑, 1,   FOXO3↑, 3,   HDAC?, 1,   HDAC↓, 4,   HDAC↑, 1,   HDAC2↓, 1,   HDAC3↓, 1,   miR-34a↓, 1,   other↓, 5,   other↑, 9,   other↝, 11,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 9,   CHOP/DDIT3↑, 2,   eIF2α↓, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 15,   GRP78/BiP↓, 9,   GRP78/BiP↑, 4,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 7,   HSP70/HSPA5↝, 1,   HSPs↑, 3,   IRE1↓, 1,   NQO2↑, 1,   PERK↓, 1,   p‑PERK↑, 1,   UPR↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   ATG5↓, 1,   ATG7↓, 1,   autophagy↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 1,   LC3s↓, 1,   MitoP↓, 1,   MitoP↑, 3,   p62↓, 2,   p62↑, 6,   PARK2↑, 3,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 12,   DNArepair↑, 1,   P53↓, 4,   PARP↓, 1,   PARP∅, 1,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   PCNA↑, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   GADD45A↑, 1,   Ki-67↓, 3,   Ki-67↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↓, 1,   CHIP↑, 1,   Choline↑, 1,   Diff↓, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 2,   Ki-67↓, 3,   Ki-67↑, 1,   mTORC1↓, 1,   Nestin↑, 1,   neuroG↑, 9,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 3,   Wnt↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 11,   AP-1↓, 3,   AP-1↑, 1,   mt-ATPase↑, 1,   Ca+2↓, 11,   Ca+2↑, 2,   Ca+2↝, 3,   i-Ca+2↓, 1,   cal2↓, 1,   Cartilage↑, 3,   COL1↓, 2,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 4,   MMP2↑, 2,   MMP7↓, 1,   MMP9↓, 8,   MMP9↑, 1,   MMPs↓, 2,   MUC1↑, 1,   Na+↑, 1,   NFAT↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   SMAD3↓, 1,   p‑T-cadherin↓, 1,   TG2/TGase↓, 1,   TGF-β↓, 9,   TGF-β↑, 2,   TGF-β1↓, 3,   TGF-β1↑, 2,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 4,   TXNIP↑, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 4,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   E-sel↓, 3,   ECM/TCF↑, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 2,   Hif1a↑, 1,   NO↓, 37,   NO↑, 4,   TXA2↓, 1,   VCAM-1↓, 11,   VEGF↓, 5,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 43,   BBB↝, 1,   BBB∅, 2,   CLDN1↑, 2,   CLDN5↑, 1,   GastroP↑, 4,   GLUT1↑, 2,   GLUT2↑, 2,   GLUT3↑, 3,   GLUT4↑, 7,   H+/K+-ATPase↓, 1,   IBI↑, 5,   memfluid↑, 1,   MMP↓, 3,   MMP↑, 24,   MUC5AC↓, 1,   Na+↑, 1,   NHE3↑, 1,   OCLN↓, 1,   OCLN↑, 2,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   TRPV3↑, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   BALF-Infl↓, 1,   CB2 / CNR2↑, 2,   CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD40↓, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 76,   COX2/PTGS2↑, 2,   CXCc↓, 1,   FOXP3↑, 2,   HCAR2↑, 1,   HMGB1↓, 5,   ICAM-1↓, 9,   IFN-γ↓, 8,   IFN-γ↑, 3,   IgE↓, 1,   IL1↓, 5,   IL10↓, 11,   IL10↑, 14,   IL12↓, 5,   IL12↑, 1,   IL17↓, 8,   IL18↓, 3,   IL1α↓, 1,   IL1β↓, 99,   IL2↓, 6,   IL2↑, 1,   IL22↓, 1,   IL23↓, 3,   IL33↓, 2,   IL4↓, 7,   IL4↑, 3,   IL5↓, 1,   IL6↓, 97,   IL6↑, 4,   IL8↓, 14,   Imm↓, 1,   Imm↑, 4,   Imm↝, 1,   INF-γ↓, 3,   Inflam↓, 248,   Inflam↑, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 11,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 3,   NeuroI↓, 8,   NF-kB↓, 146,   NF-kB↑, 3,   NK cell↑, 2,   NLRP3↓, 39,   NLRP3↑, 1,   NOD1↓, 1,   p65↓, 5,   PGE2↓, 23,   PGE2↑, 1,   RAGE↓, 3,   RANTES↓, 2,   Th2↓, 1,   TLR1↓, 1,   TLR2↓, 4,   TLR4↓, 28,   TLR4↑, 1,   TNF-α↓, 139,   TRAF1↓, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 1,   5HT↓, 1,   5HT↑, 6,   Ach↑, 9,   AChE↓, 45,   AChE↑, 1,   ADAM10↑, 2,   BChE↓, 7,   BDNF↓, 1,   BDNF↑, 47,   BDNF⇅, 1,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 8,   ChE↓, 1,   GABA↓, 1,   GABA↑, 3,   GDNF↑, 1,   MAOA↓, 7,   MAOB↓, 2,   NGF↑, 9,   PSD95↑, 6,   RELN↑, 1,   SNAP25↑, 3,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 5,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 9,   Aβ↓, 54,   Aβ42↓, 6,   BACE/β-secretase↓, 25,   IDE↑, 2,   PSEN1/PS1↓, 1,   tau↓, 12,   p‑tau↓, 20,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AhR↑, 3,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   AR↓, 1,   BNP↓, 1,   cortisol↓, 1,   CYP19↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↑, 2,   GR↝, 1,   NR1H4↑, 1,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 18,   p‑PPARγ↓, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv?, 1,   BioAv↓, 44,   BioAv↑, 49,   BioAv↝, 32,   BioEnh↑, 1,   ChemoSen↑, 3,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2C6↑, 1,   CYP2D1↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   CYP3A2↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 39,   eff↓, 8,   eff↑, 40,   eff↝, 3,   GSTA1↓, 1,   GSTA1↑, 2,   GSTP1/GSTπ↓, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 6,   Half-Life↑, 4,   Half-Life↝, 18,   Half-Life∅, 1,   MRP↓, 1,   P-gp/ABCB1↓, 1,   P450↑, 2,   selectivity↑, 2,   Synergy↑, 25,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 32,   ALB↑, 1,   ALP↓, 6,   AR↓, 1,   AST↓, 33,   BG↓, 2,   Bil↓, 1,   Bil↑, 2,   BloodF↑, 3,   BMD↑, 4,   BP↓, 8,   BP↝, 2,   BP∅, 1,   p‑BRCA1↑, 1,   BUN?, 1,   BUN↓, 6,   CEA↓, 1,   colonLen↑, 2,   creat↓, 13,   CRP↓, 10,   Ferritin↑, 2,   IL6↓, 97,   IL6↑, 4,   IRes↑, 1,   IRes↝, 1,   LDH↓, 12,   LDH↑, 3,   NOS2↓, 3,   RAGE↓, 3,   SpO2↑, 1,   TC↓, 3,   TG/TAG↓, 3,   TMAO↓, 1,   Urea↓, 3,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   Analgesic↑, 2,   AntiAge↑, 11,   antiAll?, 1,   antiAll↑, 18,   AntiArt↑, 6,   AntiCan↑, 22,   antiCG↑, 2,   AntiDiabetic↑, 16,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↑, 8,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 79,   CardioT↓, 3,   chemoP↑, 19,   chemoPv↑, 3,   cognitive↓, 1,   cognitive↑, 86,   diuretic↑, 2,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 3,   hepatoP↑, 73,   Learn↑, 14,   memory↑, 76,   Mood↑, 4,   motorD↓, 1,   motorD↑, 11,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 184,   NP/CIPN↓, 3,   Obesity↓, 17,   OS↑, 9,   Pain↓, 6,   QoL↓, 1,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 36,   Risk↓, 2,   Sleep↑, 2,   Strength↑, 5,   Stress↓, 1,   Stroke↓, 18,   toxicity?, 1,   toxicity↓, 32,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 10,   toxicity∅, 7,   Weight↓, 3,   Weight↑, 2,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 12,   AntiFungal↑, 4,   AntiP↑, 2,   AntiViral↑, 11,   Bacteria↓, 19,   Diar↓, 3,   GutMicro↑, 35,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 7,  
Total Targets: 786

Scientific Paper Hit Count for: NRF2, nuclear factor erythroid 2-related factor 2
45 Sulforaphane (mainly Broccoli)
29 Curcumin
23 Luteolin
23 Quercetin
23 Thymoquinone
22 Resveratrol
19 Lycopene
17 EGCG (Epigallocatechin Gallate)
15 Shikonin
14 brusatol
14 Fisetin
13 Chemotherapy
13 Hydrogen Gas
13 Licochalcone A
13 Silymarin (Milk Thistle) silibinin
12 Alpha-Lipoic-Acid
12 Baicalein
11 doxorubicin
11 Ashwagandha(Withaferin A)
10 Cisplatin
10 Apigenin (mainly Parsley)
10 Chrysin
10 isoorientin
9 Silver-NanoParticles
9 Selenite (Sodium)
9 Artemisinin
9 Radiotherapy/Radiation
9 Selenium
8 Vitamin C (Ascorbic Acid)
8 Phenethyl isothiocyanate
8 Boron
8 Chlorogenic acid
8 Propolis -bee glue
8 Isoliquiritigenin
8 Kaempferol
8 Morin
8 Pterostilbene
8 Rosmarinic acid
7 Carnosic acid
7 Hyperoside
7 Piperlongumine
6 Allyl isothiocyanate
6 Allicin (mainly Garlic)
6 Berberine
6 Beta-Caryophyllene
6 Isothiocyanates
6 Honokiol
6 Isovitexin
5 Benzyl isothiocyanate
5 Betulinic acid
5 Boswellia (frankincense)
5 Crocetin
5 isoquercitrin
5 Melatonin
5 Mushroom Lion’s Mane, Hericium erinaceus
4 5-fluorouracil
4 Selenium NanoParticles
4 Vitexin
4 Matrine
4 Urolithin
3 Astaxanthin
3 Berbamine
3 xanthohumol
3 Brucea javanica
3 Capsaicin
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Carvacrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Cichoric acid / Chicoric acid
3 Cynaropicrin
3 Diindolylmethane
3 Disulfiram
3 Copper and Cu NanoParticles
3 Emodin
3 Ferulic acid
3 Gallic acid
3 Ginger/6-Shogaol/Gingerol
3 Ginkgetin
3 Linalool
3 Lutein
3 Magnetic Fields
3 Parthenolide
2 1,8-Cineole
2 Auranofin
2 Lapatinib
2 Thymol-Thymus vulgaris
2 methotrexate
2 Cinnamon
2 Carvone
2 Cucurbitacin
2 Chlorella (Chlorella vulgaris)
2 Cysteamine
2 Eugenol
2 Ginkgo biloba
2 Ginseng
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Isorhamnetin
2 Licorice
2 Magnolol
2 methylseleninic acid
2 Metformin
2 Moringa oleifera
2 Methylsulfonylmethane
2 Nimbolide
2 salinomycin
2 Taurine
1 Andrographis
1 Docetaxel
1 Baicalin
1 Biochanin A
1 Cannabidiol
1 buckwheat sprouts
1 Butyrate
1 Caffeic acid
1 Catechins
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Camu camu
1 Celastrol
1 chaetocin
1 chitosan
1 Calorie Restriction Mimetics
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Ursolic acid
1 Spirulina(Arthrospira/Limnospira)
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 Indole-3-carbinol
1 D-limonene
1 Dandelion Root
1 Ellagic acid
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 Gossypol/AT-101
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Isobavachalcone
1 iodine
1 Juglone
1 lambertianic acid
1 Modified Citrus Pectin
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 Moringin
1 Mangiferin
1 Lemon Balm/Melissa officinalis
1 Zeolite
1 Myricetin
1 Oleuropein
1 Purple Corn / Purple Maize
1 Propyl gallate
1 Phenolic Acids
1 Piperine
1 Plumbagin
1 Polyphenols
1 Sulfasalazine
1 Oxygen, Hyperbaric
1 irinotecan
1 acetazolamide
1 Salvia miltiorrhiza
1 Spermidine
1 erastin
1 Terminalia bellirica
1 Terpenoids
1 triptolide
1 Vanillic Acid
1 Mung Bean Sprouts
1 Vitamin B1/Thiamine
1 Vitamin D3
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:226  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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