P21 Cancer Research Results

P21, P21/CDKN1A: Click to Expand ⟱
Source:
Type: Proapototic
cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli.
P21 is a cyclin-dependent kinase inhibitor that plays a crucial role in regulating the cell cycle. It is encoded by the CDKN1A gene and is a key player in the cellular response to stress, including DNA damage.
P21 is often considered a tumor suppressor because its expression is upregulated in response to p53 activation, a well-known tumor suppressor protein. When DNA damage occurs, p53 can activate the transcription of the CDKN1A gene, leading to increased levels of P21, which helps prevent the proliferation of damaged cells.
In many cancers, the p53 pathway is disrupted, leading to decreased levels of P21. p21 is a apoptotic marker protein.
Cell cycle arrest gene p21
Field Suggested Entry
Target CDKN1A / p21 / p21Cip1/Waf1
Full Name Cyclin-dependent kinase inhibitor 1A
Target Class CIP/KIP-family cyclin-dependent kinase inhibitor
Main Binding Partners CDK2, CDK1, CDK4/6, cyclin complexes, PCNA
Primary Biology p53-mediated cell-cycle arrest, DNA damage response, senescence, differentiation, CDK inhibition, RB/E2F pathway suppression, apoptosis regulation
Cancer Relevance High but context-dependent: p21 can suppress tumor growth through cell-cycle arrest and senescence, but can also support apoptosis resistance, senescent-cell survival, and therapy resistance in some tumors
AD Relevance Medium: indirect relevance through neuronal cell-cycle re-entry, senescence, p53 stress signaling, and aging-related cell-cycle dysregulation
Therapeutic Direction Context-dependent. Restore/activate p21 for tumor-suppressive arrest where appropriate; inhibit or bypass p21 where it promotes apoptosis resistance, senescent-cell survival, or treatment resistance.


Scientific Papers found: Click to Expand⟱
9047- PatchO,    Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, Colon, SW480 - in-vitro, BC, MCF7 - in-vitro, PC, Bxpc-3 - in-vitro, Pca, PC3 - in-vitro, Nor, HUVECs
neuroP↑, Inflam↓, TumCG↓, Apoptosis↑, P21↑, cycD1/CCND1↓, CDK4↓, HDAC2↓, cMyc↓, HDAC↓, NF-kB↓,
9048- PatchO,    Patchouli alcohol induces G0 /G1 cell cycle arrest and apoptosis in vincristine-resistant non-small cell lung cancer through ROS-mediated DNA damage
- in-vitro, Lung, A549
ROS↑, CHK1↑, Chk2↑, TumCP↓, Tumccf↓, TumCCA↑, P53↑, P21↑, cycE/CCNE↝, P-gp/ABCB1↓, CD44↓, CD133↓, ChemoSen↑, Dose↝, p‑γH2AX↑, CSCs↓,
9049- PatchO,    Inhibitory effects of patchouli alcohol on hepatocellular carcinoma growth through accumulation of oxidative stress and inactivation of androgen receptor signaling
- vitro+vivo, HCC, HepG2 - in-vivo, Liver, HUH7
ROS?, MMP↓, DNAdam↑, TumCCA↑, Apoptosis↑, P53↑, P21↑, Fas↑, FasL↑, Casp8↑, BAX↑, Casp9↑, ChemoSen↑, AR↓, TumCP↓, selectivity↑, eff↓, Snail↓, Twist↓, ICAM-1↓, VCAM-1↓, MMP9↓, EMT↓, toxicity↓, chemoP↑,
2069- PB,    Toxic and metabolic effect of sodium butyrate on SAS tongue cancer cells: role of cell cycle deregulation and redox changes
- in-vitro, Tong, NA
TumCG↓, ROS↑, P21↑, CycB/CCNB1↓, cDC2↓, CDC25↓, eff↓, TumCCA↑, Apoptosis↑,
2026- PB,    Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: A dose escalation and pharmacologic study
- Trial, GBM, NA
Dose↝, Dose↑, Dose↝, OS↑, HDAC↓, TumCCA↑, P21↑, other↝, BioAv↑, eff↑,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP/DDIT3↑, AR↓, other?,
2035- PB,    Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease
- in-vitro, Nor, glial - in-vivo, NA, NA
*ROS↓, *Inflam↑, *P21↓, *antiOx↑, *GSH↑, *NF-kB↓, *neuroP↑, *HDAC↓, *iNOS↓, *TNF-α↓, *IL1β↓, *LDL↓, ROS↓,
2045- PB,    Phenylbutyrate—a pan-HDAC inhibitor—suppresses proliferation of glioblastoma LN-229 cell line
- in-vitro, GBM, LN229 - in-vitro, GBM, LN-18
HDAC↓, TumCG↓, TumCCA↑, P21↑, Bcl-2↓, Bcl-xL↓, BioAv↑,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2/PTGS2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, Synergy↑, Synergy↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1676- PBG,    Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
- Review, Var, NA
ROS↑, MMP↓, Bcl-2↓, Synergy↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,
1661- PBG,    Propolis: a natural compound with potential as an adjuvant in cancer therapy - a review of signaling pathways
- Review, Var, NA
JNK↓, ERK↓, Akt↓, NF-kB↓, FAK↓, MAPK↓, PI3K↓, Akt↓, P21↑, p27/CDKN1B↑, TRAIL↑, BAX↑, P53↑, ERK↓, ChemoSen↑, RadioS↑, Glycolysis↓, HK2↓, PKM2↓, LDHA↓, PFK↓,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
1666- PBG,    Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
- Review, Var, NA
ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2/PTGS2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27/CDKN1B↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,
2430- PBG,    The cytotoxic effects of propolis on breast cancer cells involve PI3K/Akt and ERK1/2 pathways, mitochondrial membrane potential, and reactive oxygen species generation
- in-vitro, BC, MDA-MB-231
TumCP↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eff↓, MMP↓, LDH↑, ATP↓, Ca+2↑,
4947- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G0/G1   Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
AntiCan↑, chemoPv↑, TumCG↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑,
4948- PEITC,    Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo
- vitro+vivo, Oral, CAL27 - vitro+vivo, Oral, FaDu - vitro+vivo, Oral, SCC4 - vitro+vivo, Oral, SCC9
TumCD↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,
4963- PEITC,    Sensory Acceptable Equivalent Doses of β - Phenylethyl isothiocyanate (PEITC) Induce Cell Cycle Arrest and Retard Growth of p53 Mutated Oral Cancer In Vitro and In Vivo
- vitro+vivo, Oral, CAL27 - vitro+vivo, Oral, FaDu - vitro+vivo, Oral, SCC4 - vitro+vivo, Oral, SCC9
Dose↝, selectivity↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,
4924- PEITC,    Nutri-PEITC Jelly Significantly Improves Progression-Free Survival and Quality of Life in Patients with Advanced Oral and Oropharyngeal Cancer: A Blinded Randomized Placebo-Controlled Trial
- Trial, Oral, NA
QoL↑, P53↑, OS↑, Cyt‑c↝, other↝, ROS↑, selectivity↑, P21↑, TumCCA↑, Dose↝, BioAv↑, Weight↑, chemoP↑,
4940- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G 0/G 1 Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, tumCV↓, ROS↑, Ca+2↑, CDC25↓, CDK6↓, cycD1/CCND1↓, CDK2↓, cycE/CCNE↓, P53↑, p27/CDKN1B↑, P21↑, Casp9↑, Casp3↑, GRP78/BiP↑,
9017- Phyco,    Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
eff↑, TumCP↓, Tumccf↓, TumCCA↑, cycE/CCNE↓, CDK2↓, P21↑, Apoptosis↑, γH2AX↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, TumCMig↓, TumCA↑, angioG↓, COX2/PTGS2↓, PGE2↓, MAPK↓, toxicity↓,
9011- Phyco,    Phycocyanin: A Potential Drug for Cancer Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Imm↑, *RenoP↑, *hepatoP↑, Synergy↑, EMT↓, TumCCA↑, P21↑, cycE/CCNE↓, CDK2↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, Bax:Bcl2↑, MMP↓, ROS↑, CD59↑, Fas?, IL1β↓, IL2↓, IFN-γ↓, TNF-α↓, JAK3↓, STAT3↓, IL4↑, COX2/PTGS2↓, PGE2↓, MMP9↓, MMP2↓, MMP9↓, TIMP2↓, Vim↓, COL1↓, E-cadherin↑, MDR1↓, AP-1↓, ChemoSen↑, chemoP↑, RadioS↑, TumAuto↑,
2957- PL,    Piperlongumine Induces Cell Cycle Arrest via Reactive Oxygen Species Accumulation and IKKβ Suppression in Human Breast Cancer Cells
- in-vitro, BC, MCF7
TumCP↓, TumCMig↓, TumCCA↑, ROS↑, H2O2↑, GSH↓, IKKα↓, NF-kB↓, P21↑, eff↓,
2945- PL,    Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells
- in-vitro, CRC, HCT116
ROS↑, SMAD4↑, ChemoSen↑, P53↑, P21↑, BAX↑, Bcl-2↓, survivin↓, TumCMig↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
1942- PL,    Piperlongumine inhibits antioxidant enzymes, increases ROS levels, induces DNA damage and G2/M cell cycle arrest in breast cell lines
- in-vitro, BC, MCF7
ROS↑, SOD1↑, Trx1↓, Catalase↓, PrxII↓, ROS↑, GADD45A↑, P21↑, DNAdam↑, TumCCA↑,
5162- PLB,    Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells
- vitro+vivo, Melanoma, A172
TumCG↓, TumCCA↑, Apoptosis↑, P21↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDC2↓, CDC25↑, Bax:Bcl2↑, Casp9↑, ROS↑, JNK↑, ERK↑, eff↓,
5161- PLB,    Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
- in-vitro, SCC, SCC25
TumCCA↑, Apoptosis↑, TumAuto↑, Bcl-2↓, Bcl-xL↓, BAX↑, PI3K↓, Akt↓, mTOR↓, GSK‐3β↓, MAPK↓, ROS↑, eff↓, CDC2↓, CycB/CCNB1↓, P21↑, p27/CDKN1B↑, P53↑, Casp9↑, Casp3↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, cycD1/CCND1↓, PCNA↓, P21↑, p27/CDKN1B↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2/PTGS2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3352- QC,    A review of quercetin: Antioxidant and anticancer properties
- Review, Var, NA
*antiOx↑, *lipid-P↓, *TNF-α↓, *NF-kB↓, *COX2/PTGS2↓, *IronCh↑, P53↓, TumCCA↑, HSPs↓, P21↓, RAS↓, ER(estro)↑, OS?,
66- QC,    Emerging impact of quercetin in the treatment of prostate cancer
- Review, Pca, NA
CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓, TumCCA↑, ROS↑, miR-21↓, TumCP↓, selectivity↑, PDGF↓, EGF↓, TNF-α↓, VEGFR2/KDR/Flk1↓, mTOR↓, cMyc↓, MMPs↓, GRP78/BiP↑, CHOP/DDIT3↑,
36- QC,    Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression-independent manner in HPV-positive human cervical cancer-derived cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa
P53↑, P21↑, BAX↑, Casp3↑, Casp7↑, TumCCA↑, ROS↑, TumCCA↑, Apoptosis↑,
84- QC,    Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression
- in-vitro, Pca, PC3
P21↑, cDC2↓, CDK1↓, CycB/CCNB1↓, Casp3↑, Bcl-2↓, Bcl-xL↓, BAX↑, pRB↓, TumCCA↑, Apoptosis↑,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4/6↓, E2Fs↓, PCNA↓, cDC2↓, PTEN↑, MSH2↑, P21↑, EP300↑, BRCA1↑, NF2↑, TSC1↑, TGFβR1↑, P53↑, RB1↑, AKT1↓, cMyc↓, CDC7↓, cycF↓, CDC16↓, CUL4B↑, CBP↑, TSC2↑, HER2/EBBR2↓, BCR↓, TumCCA↑, chemoPv↑,
913- QC,    Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-435
TumCP↓, TumCCA↑, DNAdam↑, Chk2↑, CycB/CCNB1↓, CDK1↓, tumCV↓, p‑RB1↓, P21↑,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,
3088- RES,    Notch signaling mediated repressive effects of resveratrol in inducing caspasedependent apoptosis in MCF-7 breast cancer cells
- in-vitro, BC, MCF7
NOTCH1↓, BAX↑, CDK4↝, Casp3↑, P21↑,
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
TumCG↓, P21↑, p27/CDKN1B↑, CycB/CCNB1↓, ROS↑, ER Stress↑, p‑p38↑, P53↑, p‑eIF2α↑, EP4/PTGER4↑, CHOP/DDIT3↑, Bcl-2↓, BAX↓, TumCCA↑, NRF2↓, ChemoSen↑, GSH↓,
3055- RES,    Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
BioAv↓, BioAv↓, Dose↑, eff↑, eff↑, Dose↑, BioAv↑, ROS↑, MMP↓, P21↑, p27/CDKN1B↑, TumCCA↑, ChemoSen↑, COX2/PTGS2↓, 5LO↓, VEGF↓, IL1↓, IL6↓, IL8↓, AR↓, PSA↓, MAPK↓, Hif1a↓, Glycolysis↓, miR-21↓, PTEN↑, Half-Life↝, *IGF-1↓, *IGFBP3↑, Half-Life↓,
3056- RES,    Less is more for cancer chemoprevention: evidence of a non-linear dose response for the protective effects of resveratrol in humans and mice
- in-vivo, Nor, NA
*AMPK↑, *P21↑, *Dose↓, *chemoPv↑,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoPv↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2/PTGS2↓, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,
2982- RES,    The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1
- in-vitro, Melanoma, MSTO-211H
tumCV↓, Apoptosis↑, Sp1/3/4↓, p27/CDKN1B↓, P21↓, cycD1/CCND1↓, Mcl-1↓, survivin↓,
3035- RosA,    Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling
- in-vitro, PC, NA - in-vivo, NA, NA
Gli1↓, TumCCA↑, TumCMig↓, TumCI↓, CDK2↓, cycE/CCNE↓, P21↑, p27/CDKN1B↑,
3029- RosA,    Rosmarinic Acid, a Component of Rosemary Tea, Induced the Cell Cycle Arrest and Apoptosis through Modulation of HDAC2 Expression in Prostate Cancer Cell Lines
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
TumCP↓, tumCV↓, Apoptosis↑, HDAC2↓, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21↑, DNAdam↑, Casp3↑,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
323- Sal,  AgNPs,    Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy
- in-vitro, BC, MDA-MB-231 - in-vitro, Ovarian, A2780S
TumCD↑, LDH↓, MDA↑, SOD↓, ROS↑, GSH↓, Catalase↓, MMP↓, P53↑, P21↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Apoptosis↑, TumAuto↑,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
4995- Sal,    Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway
- vitro+vivo, BC, MDA-MB-231
ALDH↓, Nanog↓, OCT4↓, SOX2↓, CSCs↓, tumCV↓, cycD1/CCND1↓, P21↑, TumCG↓, CD44↓, Apoptosis∅,

Showing Research Papers: 251 to 300 of 349
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 349

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 3,   antiOx↑, 10,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 4,   Catalase↑, 4,   Copper↑, 1,   Fenton↑, 1,   GPx↓, 1,   GPx↑, 7,   GPx1↓, 1,   GPx4↓, 2,   GSH↓, 21,   GSH↑, 9,   GSH/GSSG↓, 1,   GSR↑, 2,   GSS↑, 1,   GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 12,   HO-2↓, 1,   Iron↓, 1,   i-Iron↑, 1,   lipid-P↓, 6,   lipid-P↑, 2,   MDA↓, 2,   MDA↑, 4,   MPO↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 20,   NRF2↝, 1,   PAO↑, 1,   Prx4↑, 1,   PrxII↓, 1,   ROS?, 1,   ROS↓, 21,   ROS↑, 159,   ROS⇅, 8,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 1,   SAM-e↝, 1,   SOD↓, 5,   SOD↑, 6,   SOD1↑, 2,   SOD2↓, 2,   SOD2↑, 1,   Trx↑, 1,   Trx1↓, 1,   Trx1↑, 1,   TrxR↓, 3,   TrxR↑, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR↓, 1,   CDC16↓, 1,   CDC2↓, 8,   CDC2↑, 1,   CDC25↓, 19,   CDC25↑, 1,   compI↓, 1,   compIII↓, 1,   EGF↓, 3,   ETC↓, 3,   HSP60/HSPD1↓, 2,   Insulin↓, 2,   mitResp↓, 2,   mtDam↑, 14,   OCR↓, 2,   OCR↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 1,   PDH↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5-HETE↓, 1,   5LO↓, 4,   ACC↑, 2,   ALAT↓, 2,   ALAT↝, 1,   ALDOA↓, 1,   AMPK↓, 2,   AMPK↑, 16,   p‑AMPK↑, 1,   ATP↓, 9,   CAIX/CA9↑, 1,   CholSyn↓, 1,   ECAR↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FAO↑, 1,   FASN↓, 5,   G6PD↓, 1,   GlucoseCon↓, 5,   GlucoseCon∅, 1,   Glycolysis↓, 17,   GSK‐3β↓, 11,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 4,   H2S↑, 1,   Histones↑, 1,   HK2↓, 12,   HMG-CoA↓, 1,   lactateProd↓, 5,   lactateProd∅, 1,   LDHA↓, 5,   LDL↓, 3,   MCT4↓, 1,   NAD↓, 1,   NAD↝, 1,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PFK↓, 3,   PKM2↓, 9,   polyA↓, 1,   p‑S6↓, 1,   SIRT1↓, 6,   SIRT1↑, 3,   SIRT2↓, 1,   SIRT2↑, 1,   SREBP1/SREBF1↓, 2,   SSAT↑, 1,   TCA↓, 1,   TS↓, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 14,   APAF1↑, 7,   Apoptosis?, 2,   Apoptosis↓, 6,   Apoptosis↑, 153,   Apoptosis↝, 1,   Apoptosis∅, 1,   mt-Apoptosis↑, 3,   ASK1↑, 1,   BAD↑, 11,   Bak↑, 8,   BAX↓, 5,   BAX↑, 106,   BAX⇅, 1,   BAX↝, 2,   BAX∅, 1,   Bax:Bcl2↑, 35,   Bcl-2↓, 95,   Bcl-2↑, 6,   Bcl-2↝, 2,   Bcl-2∅, 1,   Bcl-xL↓, 36,   Bcl-xL↑, 1,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 1,   BID↑, 7,   p‑BID↓, 1,   BIM↑, 5,   BNIP3↑, 1,   BTG3↑, 1,   Casp↑, 28,   Casp1↑, 3,   Casp10↑, 2,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 3,   Casp3↑, 116,   Casp3↝, 2,   cl‑Casp3↑, 23,   proCasp3↓, 1,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 15,   cl‑Casp7↑, 2,   Casp8↑, 29,   Casp8∅, 1,   cl‑Casp8↑, 6,   proCasp8↓, 1,   Casp9↑, 78,   cl‑Casp9↑, 10,   proCasp9↓, 2,   cFLIP↓, 3,   Cyt‑c↓, 2,   Cyt‑c↑, 67,   Cyt‑c↝, 4,   mt-Cyt‑c↓, 1,   Diablo↑, 9,   DR5↓, 1,   DR5↑, 16,   FADD↑, 3,   Fas?, 1,   Fas↓, 1,   Fas↑, 14,   FasL↑, 7,   Ferroptosis↑, 1,   HEY1↓, 1,   IAP1↓, 6,   IAP2/BIRC3↓, 2,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 11,   iNOS↑, 1,   Mcl-1?, 1,   Mcl-1↓, 11,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 13,   MDM2↑, 1,   necrosis↑, 1,   NOXA↑, 3,   p38↓, 4,   p38↑, 17,   p‑p38↑, 4,   PUMA↓, 1,   PUMA↑, 7,   RIP3↑, 1,   survivin↓, 47,   survivin↝, 1,   TRAIL↑, 7,   TRAILR↑, 1,   TumCD↑, 13,   TUNEL↑, 1,   XIAP↓, 20,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 83,   Akt↑, 4,   Akt↝, 1,   p‑Akt↓, 25,   p‑Akt↑, 1,   AKT1↓, 2,   AMPKα↑, 1,   BRAF↝, 1,   CaMKII ↓, 1,   CDC7↓, 1,   CK2↓, 3,   cMET↓, 3,   EF-1α↓, 1,   EGFR↓, 31,   EGFR↝, 1,   p‑EGFR↓, 1,   ERK↓, 33,   ERK↑, 6,   p‑ERK↓, 8,   p‑ERK↑, 2,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   IGF-1R↓, 2,   IKKα↓, 5,   p‑IKKα↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   JAK↓, 3,   JAK1↓, 2,   JAK2↓, 5,   p‑JAK2↓, 1,   JAK3↓, 1,   p‑JAK3↓, 1,   JNK↓, 6,   JNK↑, 23,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 1,   MAP2K1/MEK1↓, 1,   MAPK↓, 26,   MAPK↑, 10,   MAPK↝, 2,   MEK↓, 1,   p‑MEK↓, 1,   mTOR↓, 46,   mTOR↑, 1,   mTOR↝, 1,   p‑mTOR↓, 7,   mTORC2↓, 2,   p‑p42↓, 1,   p70S6↓, 2,   p70S6↑, 1,   P70S6K↓, 4,   P90RSK↓, 1,   PDGFR-BB↓, 2,   PI3K↓, 58,   PI3K↑, 1,   PI3K↝, 2,   p‑PI3K↓, 1,   PI3K/Akt↓, 2,   PI3K/Akt↝, 1,   PI3K/mTOR/ETS2↓, 1,   PIAS-3↑, 1,   PIK3CA↓, 1,   PKCδ↓, 7,   p‑PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 16,   PTEN↝, 2,   Raf↓, 4,   c-Raf↓, 1,   RAS↓, 11,   RIP1↓, 1,   RIP1↑, 1,   S6K↓, 1,   Sp1/3/4↓, 9,   Src↓, 2,   STAT↓, 2,   STAT3↓, 47,   STAT3↑, 2,   p‑STAT3↓, 6,   STAT5↓, 2,   STAT6↓, 1,   STK11/LKB1↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 9,   ATF4↝, 1,   CBP↑, 2,   ChrMod↑, 1,   cJun↓, 4,   cJun↑, 3,   p‑cJun↑, 1,   cMyc↓, 29,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 3,   DNMTs↓, 4,   EZH2↓, 1,   FOXM1↓, 5,   FOXO↑, 2,   FOXO1↓, 2,   FOXO3↓, 4,   FOXO3↑, 4,   p‑FOXO3↓, 1,   FOXO4↓, 1,   GATA3↑, 1,   H3↓, 1,   H3↑, 3,   p‑H3↑, 1,   ac‑H3↑, 8,   H3K9↓, 1,   H4↑, 1,   ac‑H4↑, 6,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 31,   HDAC1↓, 8,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 6,   HDAC3↓, 5,   HDAC4↓, 2,   HDAC8↓, 3,   HES1↓, 1,   HMTs↓, 1,   IRF1↑, 1,   miR-106b↓, 1,   miR-130a↓, 1,   miR-133a-3p↑, 1,   miR-155↓, 1,   miR-192-5p↑, 1,   miR-203↑, 1,   miR-21↓, 3,   miR-29b↑, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-99↑, 1,   MTA2↓, 1,   Myc↓, 7,   MYCN↓, 1,   MYCN↑, 1,   OCT4↓, 9,   OCT4↑, 1,   OLIG2↓, 1,   other?, 1,   other↑, 1,   other↝, 6,   PAX2↓, 1,   SOX2↓, 6,   SOX4↓, 2,   SOX4↑, 2,   SOX9↓, 2,   SUV39H↓, 2,   TCF-4↓, 2,   TET3↑, 1,   tumCV↓, 41,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↑, 22,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 4,   p‑eIF2α↑, 4,   ER Stress↓, 2,   ER Stress↑, 30,   GRP78/BiP↓, 2,   GRP78/BiP↑, 10,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 5,   HSPs↓, 2,   HTRA↓, 2,   IRE1↑, 4,   PERK↑, 4,   Proteasome↓, 1,   UPR↑, 3,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↓, 1,   ATG5↑, 3,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 7,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 2,   LC3I↓, 1,   LC3II↓, 1,   LC3II↑, 7,   LC3s↑, 1,   p62↓, 3,   p62↑, 3,   TumAuto↓, 2,   TumAuto↑, 19,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 6,   ATR↑, 3,   BRCA1↓, 1,   BRCA1↑, 4,   p‑BRCA1↑, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↓, 1,   DNAdam↓, 3,   DNAdam↑, 56,   DNArepair↓, 1,   DNArepair↑, 1,   hTERT/TERT↓, 10,   MDMX↓, 1,   MSH2↑, 1,   p16↑, 6,   P53↓, 6,   P53↑, 134,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 4,   p53 Wildtype↓, 1,   PARP↓, 2,   PARP↑, 8,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 56,   PARP1↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 29,   PCNA↝, 1,   SIRT6↑, 1,   Telomerase↓, 10,   TOP1↓, 2,   TOP2↓, 7,   TP53↓, 2,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 11,   p‑γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

AURKB↓, 1,   CDK1↓, 21,   CDK1↑, 4,   p‑CDK1↓, 2,   CDK2↓, 61,   CDK2↑, 1,   CDK4↓, 71,   CDK4↑, 2,   CDK4↝, 1,   p‑CDK4↓, 1,   CDK4/6↓, 3,   CDK6↓, 24,   CDK6↑, 3,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN2C/p18↑, 2,   cellSen↑, 1,   CHK1↓, 4,   CHK1↑, 4,   Chk2↓, 4,   Chk2↑, 6,   p‑Chk2↑, 1,   Cyc↓, 6,   Cyc↝, 1,   cycA1/CCNA1↓, 22,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 40,   CycB/CCNB1↑, 4,   cycD1/CCND1↓, 116,   cycD1/CCND1↑, 3,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 3,   cycE/CCNE↓, 45,   cycE/CCNE↑, 1,   cycE/CCNE↝, 1,   cycE1↓, 1,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 7,   E2Fs↑, 1,   GADD45A↑, 4,   Ki-67↓, 18,   mitA↑, 1,   p19↑, 1,   P21?, 2,   P21↓, 22,   P21↑, 316,   P21↝, 2,   p‑P21↑, 1,   p27/CDKN1B↓, 8,   p27/CDKN1B↑, 86,   pRB↓, 4,   pRB↑, 3,   p‑pRB↓, 3,   RB1↓, 1,   RB1↑, 4,   p‑RB1↓, 8,   cl‑RB1↓, 1,   TumCCA?, 3,   TumCCA↓, 2,   TumCCA↑, 219,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 4,   ALDH1A1↓, 3,   BMPs↑, 1,   CD133↓, 6,   CD24↓, 2,   cFos↓, 7,   CSCs↓, 22,   Diff↑, 3,   EIF4E↓, 1,   EP300↑, 1,   EP4/PTGER4↑, 1,   Gli1↓, 3,   HH↓, 1,   HMGCR↓, 2,   IGF-1↓, 7,   IGFBP3↑, 3,   IGFBP7↑, 1,   p‑Jun↓, 1,   Ki-67↓, 18,   Let-7↑, 1,   mTORC1↓, 5,   Nanog↓, 10,   Nanog↑, 1,   Nestin↓, 2,   NF2↑, 1,   NICD↓, 1,   NOTCH↓, 10,   NOTCH1↓, 8,   NOTCH2↑, 1,   NOTCH3↓, 2,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 2,   STAT1↓, 1,   p‑STAT1↓, 1,   TAZ↓, 1,   TOPflash↑, 1,   TumCG?, 2,   TumCG↓, 60,   TumCG↑, 1,   TumCP↓, 119,   TumCP↑, 1,   TumCP⇅, 1,   Wnt?, 1,   Wnt↓, 24,   Wnt↝, 1,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 13,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 20,   Ca+2↝, 1,   i-Ca+2↑, 2,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↓, 1,   cal2↑, 2,   Cdc42↑, 1,   COL1↓, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 4,   E-cadherin↑, 22,   EMT?, 1,   EMT↓, 39,   F-actin↓, 1,   FAK↓, 9,   p‑FAK↓, 3,   Fibronectin↓, 2,   GLI2↓, 2,   ITGA5↓, 1,   ITGB4↓, 1,   LAMs↓, 1,   MALAT1↓, 1,   MET↓, 2,   MMP1↓, 3,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 48,   MMP2↝, 1,   MMP3↓, 3,   MMP7↓, 10,   MMP9↓, 61,   MMP9↑, 1,   MMPs↓, 17,   MUC4↓, 2,   N-cadherin↓, 13,   p44↓, 1,   p‑p44↓, 1,   PAK1↓, 1,   PDGF↓, 5,   Rho↑, 1,   ROCK1↓, 2,   ROCK1↑, 1,   Sharpin↓, 1,   Slug↓, 9,   SMAD3↓, 1,   SMAD3↑, 1,   SMAD4↑, 1,   Snail↓, 15,   TET1↑, 2,   TGF-β↓, 6,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 1,   TIMP2↑, 3,   TRIB3↑, 1,   TSC1↑, 1,   TumCA↓, 1,   TumCA↑, 1,   TumCI↓, 46,   TumCI↑, 1,   TumCMig↓, 43,   TumMeta↓, 43,   TumMeta↑, 5,   Twist↓, 17,   TXNIP↑, 1,   uPA↓, 13,   uPAR↓, 1,   Vim↓, 22,   Zeb1↓, 9,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 28,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 44,   angioG↑, 2,   CD31/PECAM-1↓, 2,   Endoglin↑, 2,   eNOS↓, 2,   eNOS↑, 1,   HIF-1↓, 2,   Hif1a↓, 39,   Hif1a↑, 1,   LOX1↓, 2,   NO↓, 1,   NO↑, 4,   VCAM-1↓, 2,   VEGF↓, 62,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 9,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN2↓, 1,   EPR↑, 2,   GLUT1↓, 3,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 76,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 2,   SVCT-2↝, 1,   TRPM7↓, 2,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CD25+↑, 1,   CD4+↑, 3,   CD44↓, 13,   CD59↑, 1,   CD8+↑, 1,   cDC2↓, 6,   COX1?, 1,   COX1↓, 3,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 54,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCR4↓, 8,   DCells↑, 1,   DR4↑, 4,   Eos↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   Igs↑, 1,   IL1↓, 5,   IL1↑, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 2,   IL1β↓, 11,   IL2↓, 2,   IL2↑, 2,   IL4↓, 2,   IL4↑, 3,   IL6↓, 19,   IL6↝, 1,   IL7↓, 1,   IL8↓, 7,   IL8↑, 1,   Imm↑, 7,   Imm↝, 1,   Inflam↓, 17,   Inflam↝, 1,   IRAK1↓, 1,   MCP1/CCL2↓, 1,   Neut↑, 1,   NF-kB↓, 103,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 2,   p50↓, 1,   p65↓, 8,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-L1↓, 5,   PGD2↓, 1,   PGE2↓, 13,   PSA↓, 12,   PSA↝, 1,   PSA∅, 1,   RANTES↓, 1,   SOCS-3↑, 1,   SOCS1↑, 2,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 1,   TLR4↓, 3,   TNF-α↓, 20,   TNF-α↑, 5,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 2,   AR↓, 19,   AR↝, 1,   ER-α36↓, 3,   ER(estro)↓, 1,   ER(estro)↑, 1,   Estro↝, 1,   FGF21↓, 1,   GR↑, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 6,   RANKL↓, 2,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 24,   BioAv↑, 19,   BioAv↝, 3,   BioEnh↑, 1,   ChemoSen↓, 4,   ChemoSen↑, 90,   ChemoSen⇅, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 4,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   Dose?, 1,   Dose↑, 4,   Dose↝, 32,   Dose∅, 10,   eff↓, 29,   eff↑, 44,   eff↝, 3,   eff∅, 1,   GSTA1↑, 2,   Half-Life↓, 7,   Half-Life↝, 9,   MDR1↓, 7,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 14,   P450↓, 5,   P450↝, 1,   RadioS↑, 30,   selectivity?, 1,   selectivity↑, 60,   selectivity↝, 1,   Synergy↑, 49,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALAT↝, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 19,   AR↝, 1,   AST↓, 2,   AST↝, 1,   B2M↓, 1,   BRAF↝, 1,   BRCA1↓, 1,   BRCA1↑, 4,   p‑BRCA1↑, 1,   E6↓, 4,   E7↓, 4,   EGFR↓, 31,   EGFR↝, 1,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 5,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 19,   IL6↝, 1,   LDH↓, 5,   LDH↑, 1,   Maspin↑, 2,   Myc↓, 7,   PD-L1↓, 5,   PSA↓, 12,   PSA↝, 1,   PSA∅, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 3,   TRIB3↑, 1,   Tumccf↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 35,   AntiTum↑, 10,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 6,   chemoP↑, 13,   chemoPv↑, 11,   ChemoSideEff↓, 2,   fatigue↓, 1,   FTO↑, 1,   hepatoP↑, 10,   Mucositis↓, 1,   neuroP↑, 6,   OS?, 1,   OS↑, 10,   OS⇅, 1,   Pain↓, 2,   PFS↑, 1,   QoL↑, 5,   radioP↑, 5,   Remission↑, 2,   RenoP↑, 7,   Risk↓, 10,   Sleep↑, 2,   Strength↑, 2,   TGFβR1↑, 1,   toxicity↓, 11,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,   TumVol↓, 18,   TumW↓, 8,   Weight↓, 1,   Weight↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,   GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 3,  
Total Targets: 921

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 40,   Catalase↑, 16,   GPx↓, 1,   GPx↑, 14,   GSH↑, 23,   GSR↑, 3,   GSSG↓, 1,   GSTs↑, 5,   HDL↓, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 5,   Iron∅, 1,   Keap1↓, 2,   Keap1↑, 1,   lipid-P↓, 16,   MDA↓, 14,   MPO↓, 2,   MPO↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 19,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 39,   ROS↑, 3,   SOD↓, 1,   SOD↑, 20,   SOD1↑, 2,   SOD2↓, 1,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 1,   Trx↓, 1,   Trx↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   ACSL4↓, 1,   adiP↑, 1,   ALAT↓, 7,   AMPK↓, 1,   AMPK↑, 3,   ATP↓, 1,   ATP↑, 2,   FASN↓, 1,   glucose↓, 2,   glucose↝, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 3,   NAD↓, 1,   NADPH↑, 1,   PONs↓, 1,   SCFAs↑, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↓, 3,   BAX↓, 1,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 2,   Casp3?, 1,   Casp3↓, 4,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 2,   Casp9↓, 3,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 2,   Fas↓, 1,   Fas↑, 2,   Ferroptosis↓, 1,   iNOS↓, 8,   necrosis↓, 1,   p38↓, 2,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 3,   mTOR↓, 1,   PI3K↓, 1,   PKCδ↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   p‑cMyc↑, 1,   HDAC↓, 2,   HDAC3↓, 1,   other↓, 1,   other↑, 1,   other↝, 3,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSPs↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   p16↓, 1,   P53↓, 4,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK5↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 6,   P21↑, 6,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   Ki-67↓, 1,   TumCG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 2,   Rho↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   E-sel↓, 1,   HIF2a↑, 1,   NO↓, 3,   NO↑, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT2↑, 1,   GLUT4↑, 1,   MMP↓, 3,   MMP↑, 1,   MUC5AC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 15,   ICAM-1↓, 1,   IFN-γ↓, 3,   IFN-γ↑, 2,   IL1↓, 1,   IL10↓, 3,   IL17↓, 2,   IL1β↓, 7,   IL23↓, 1,   IL5↓, 1,   IL6↓, 10,   IL8↓, 3,   Imm↓, 1,   Imm↑, 2,   Inflam↓, 38,   Inflam↑, 2,   MCP1/CCL2↓, 1,   NF-kB↓, 15,   NK cell↑, 2,   NLRP3↓, 1,   PGE2↓, 6,   PGE2↑, 1,   RAGE↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 4,   TNF-α↓, 13,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 2,   AChE↑, 1,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 2,   MAOA↓, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 3,   BACE/β-secretase↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   FGF21↑, 1,   GPER↑, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 17,   BioAv↑, 4,   BioAv⇅, 1,   BioAv↝, 5,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↝, 2,   eff↑, 2,   GSTA1↑, 2,   Half-Life↝, 2,   Half-Life∅, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALP↓, 2,   AST↓, 7,   BMD↑, 1,   BP↓, 2,   BP↝, 1,   creat↓, 1,   CRP↓, 2,   IL6↓, 10,   LDH↓, 3,   LDH↑, 1,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 8,   AntiArt↑, 5,   AntiCan↑, 5,   AntiDiabetic↑, 7,   AntiTum↑, 1,   cardioP?, 1,   cardioP↑, 13,   chemoP↑, 5,   chemoPv↑, 3,   cognitive↑, 4,   hepatoP↑, 14,   Learn↑, 1,   memory↑, 7,   neuroP↑, 27,   Obesity↓, 3,   OS↑, 2,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 1,   Stroke↓, 2,   toxicity↓, 14,   toxicity↑, 1,   toxicity↝, 4,   toxicity∅, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 2,   AntiViral↑, 1,   Bacteria↓, 7,   GutMicro↑, 6,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 270

Scientific Paper Hit Count for: P21, P21/CDKN1A
19 Thymoquinone
14 Curcumin
13 Sulforaphane (mainly Broccoli)
12 Apigenin (mainly Parsley)
12 Fisetin
9 Silver-NanoParticles
8 EGCG (Epigallocatechin Gallate)
8 Lycopene
8 Quercetin
7 Magnolol
7 Propolis -bee glue
7 Resveratrol
6 Eugenol
6 Phenethyl isothiocyanate
5 Berberine
5 Indole-3-carbinol
5 Emodin
5 phytic acid, Inositol hexakisphosphate
5 Luteolin
5 Phenylbutyrate
5 Piperlongumine
5 Urolithin
4 Gemcitabine (Gemzar)
4 Allicin (mainly Garlic)
4 Cisplatin
4 Biochanin A
4 Beta-Caryophyllene
4 Boswellia (frankincense)
4 Cucurbitacin
4 Ursolic acid
4 Ellagic acid
4 Diindolylmethane
4 Gallic acid
4 Honokiol
4 Morin
4 Shikonin
3 Allyl isothiocyanate
3 Baicalein
3 Benzyl isothiocyanate
3 Capsaicin
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Ferulic acid
3 Isoliquiritigenin
3 Licochalcone A
3 Magnetic Fields
3 Melatonin
3 Naringin
3 Patchouli Oil (Pogostemon cablin)
3 salinomycin
3 Silymarin (Milk Thistle) silibinin
3 Zyflamend
2 Alpha-Lipoic-Acid
2 Anethole/trans-Anethole
2 Ashwagandha(Withaferin A)
2 Astaxanthin
2 Berbamine
2 Betulinic acid
2 Caffeic acid
2 Carnosic acid
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Chlorogenic acid
2 chaetocin
2 Crocetin
2 diet Methionine-Restricted Diet
2 Fenbendazole
2 Garcinol
2 Genistein (soy isoflavone)
2 HydroxyTyrosol
2 Kaempferol
2 lambertianic acid
2 Linalool
2 mebendazole
2 doxorubicin
2 Oleuropein
2 Marjoram (Origanum majorana)
2 Phycocyanin
2 Plumbagin
2 Rosmarinic acid
1 3-bromopyruvate
1 5-fluorouracil
1 Coenzyme Q10
1 Astragalus
1 Camptothecin
1 Acetyl-l-carnitine
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Artemisinin
1 Atorvastatin
1 epirubicin
1 Bufalin/Huachansu
1 Boron
1 brusatol
1 Bruteridin(bergamot juice)
1 Centella asiatica / Gotu kola → asiaticoside
1 Chrysin
1 Dihydrocaffeic Acid
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 D-limonene
1 Docetaxel
1 Dandelion Root
1 Butyrate
1 Cinnamon
1 Formononetin
1 Flaxseed/Linseed
1 SDG/lignans
1 Gambogic Acid
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Inositol
1 Isorhamnetin
1 isoorientin
1 Isothiocyanates
1 Juglone
1 Lactobacillus
1 Lactoferrin/Talactoferrin
1 Matrine
1 Dordaviprone; Modeyso
1 MCT, metronomic chemo
1 methylseleninic acid
1 Magnetic Field Rotating
1 Moringin
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Methylsulfonylmethane
1 Radiotherapy/Radiation
1 Nimbolide
1 Rutin
1 buckwheat sprouts
1 acetazolamide
1 Aflavin-3,3′-digallate
1 Oxaliplatin
1 Vitamin C (Ascorbic Acid)
1 Magnesium
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:234  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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