BAX Cancer Research Results

BAX, Apoptosis regulator BAX: Click to Expand ⟱
Source:
Type: Proapototic protein
BAX is a member of the Bcl-2 gene family.
Pro-apoptotic protein that forms heterodimers with anti-apoptotic BCL2 proteins; involved in various cellular activities and regulated by p53; mediates the release of cytochrome c from mitochondria.
Scientific Papers found: Click to Expand⟱
170- CUR,    Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis
- vitro+vivo, Pca, PC3
TRAILR↑, BAX↑, P21↑, p27/CDKN1B↑, NF-kB↓, cycD1/CCND1↓, VEGF↓, uPA↓, MMP2↓, MMP9↓, Bcl-2↓, Bcl-xL↓,
1609- CUR,  EA,    Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells
- in-vitro, Cerv, NA
Synergy↑, Dose∅, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑, Dose∅,
6214- CUR,    Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve
- Review, CardioV, NA
TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2/PTGS2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, Synergy↑, PhotoS↑, eff↑, ROS↑, GSH↓,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2/PTGS2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1/CCL2↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *Synergy↑, Synergy↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
9095- CV,    Hot water extract of Chlorella vulgaris induced DNA damage and apoptosis
- in-vitro, Liver, HepG2 - in-vitro, Nor, WRL68
tumCV↓, DNAdam↑, selectivity↑, P53↑, BAX↑, Casp3↑,
9105- CV,  AgNPs,    Apoptosis induction in colon cancer cells (SW480) by BiFe2O4@Ag nanocomposite synthesized from Chlorella vulgaris extract and evaluation the expression of CASP8, BAX and BCL2 genes
- in-vitro, Colon, SW480
selectivity↑, TumCCA↑, Casp8↑, BAX↑, Bcl-2↑, ROS↑,
7445- CYN,    Cynaropicrin Shows Antitumor Progression Potential in Colorectal Cancer Through Mediation of the LIFR/STATs Axis
- vitro+vivo, CRC, RKO - in-vitro, CRC, HCT116 - in-vitro, CRC, DLD1
tumCV↓, STAT↓, LIFR/CD118↓, STAT3↓, STAT4↑, TumCG?, cl‑PARP1↑, Bcl-2↓, BAX↑, STAT3↓, Dose↝, TumVol↓, TumW↓, toxicity↓,
7443- CYN,    Cynaropicrin, a sesquiterpene lactone, triggers apoptotic cell death in triple negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
TumCP↓, Apoptosis↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,
1878- DCA,  5-FU,    Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer
- in-vitro, CRC, LS174T - in-vitro, CRC, LoVo - in-vitro, CRC, SW-620 - in-vitro, CRC, HT-29
tumCV↓, Synergy↑, PDKs↓, lactateProd↓, Glycolysis↓, mitResp↑, TumCCA↑, Bcl-2↓, BAX↑, Casp3↑,
4455- DFE,    Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest
- in-vitro, BC, MCF7 - in-vitro, Nor, 3T3
TumCCA↑, P53↑, BAX↑, Casp3↑, MMP↓, Fas↑, FasL↑, Bcl-2↓, Apoptosis↑, TumCP↓, TUNEL↑, eff↑, selectivity↑,
6289- DL,    D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis
- in-vivo, Var, NA
COX2/PTGS2↓, *GSH↑, *GPx↑, *Catalase↑, Bcl-2↓, BAX↑, *chemoPv↑, *Inflam↓, *ROS↓, *RAS↓,
6290- DL,    Induction of apoptosis by d-limonene is mediated by a caspase-dependent mitochondrial death pathway in human leukemia cells
- in-vitro, AML, K562 - in-vitro, AML, HL-60
BAX↑, Cyt‑c↑, Casp9↑, cl‑Casp3↑, mtDam↑, Apoptosis↑,
6269- DL,    Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells
- in-vitro, CRC, LS174T
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑, cl‑PARP↑, BAX↑, Cyt‑c↑, Bcl-2↓, PI3K↓, Akt↓,
6273- DL,    D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways
- in-vitro, Colon, Caco-2 - in-vitro, Nor, HEK293 - in-vitro, Colon, HCT116
ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,
6288- DL,    From Citrus to Clinic: Limonene’s Journey Through Preclinical Research, Clinical Trials, and Formulation Innovations
- Review, Var, NA - Review, AD, NA
other↑, DDS↑, *antiOx↑, *Inflam↓, *AntiDiabetic↑, *neuroP↑, *Imm↑, *Wound Healing↑, *other↑, *BioAv↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *DNAdam↓, *AntiDiabetic↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, *AChE↓, *BChE↓, *Aβ↓, *ROS↓, *toxicity?,
6281- DL,    Applications of Limonene in Neoplasms and Non-Neoplastic Diseases
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
*antiOx↑, AntiTum↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *ROS↓, *toxicity↓, *BioAv↑, ChemoSen↑, BAX↑, P53↓, Bcl-2↓, iNOS↓, COX2/PTGS2↓, eff↑, ROS↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, TumCMig↓, *lipid-P↓, *GSH↑, *SOD↑, *GPx↑, *hepatoP↑, *glucose↓, *AGEs↓, *Obesity↓, *Aβ↓, *AChE↓,
6280- DL,    Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs
- Review, Var, NA
BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, TGF-β↑, Bcl-2↓, VEGF↓, AntiTum↑, *Inflam↓, *Bacteria↓,
6328- DRE,    Hydroalcoholic extract of Taraxacum officinale induces apoptosis and autophagy in 4T1 breast cancer cells
- in-vitro, BC, 4T1
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, DNAdam↑, BAX↑, Bax:Bcl2↑, P53↑, Beclin-1/ATG6↑, ATG7↑, Bcl-2↓, NO↓,
6343- DRE,    Dandelion root extract affects ESCC progression via regulating multiple signal pathways
- vitro+vivo, ESCC, NA
*Inflam↓, TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↓, TumCG↓, PI3K↓, p‑Akt↓, RAS↓, Raf↓, p‑ERK↓, Bcl-2↓, BAX↑,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
6744- DSF,    Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, T47D
TumCD↑, ChemoSen↑, BAX↑, Apoptosis↑, CSCs↓, ROS↑, eff↝, JNK↑, p38↑, NF-kB↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2/PTGS2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
1610- EA,    Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer
- Review, Cerv, NA
TumCCA↑, STAT3↓, P21↑, IGFBP7↑, Akt↓, mTOR↓, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, Synergy↑, COX2/PTGS2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2/PTGS2↓, Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1/ATG6↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, Synergy↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
6780- EGCG,    The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: A systematic review
- Review, AD, NA
*neuroP↑, *tau↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *AChE↓, *TNF-α↓, *JNK↓, *NGF↑, *SOD↑, *GPx↑, *MDA↓, *NO↓, *ROS↓, *iNOS↓, *COX2/PTGS2↓, *BAX↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *Bcl-2↑, *Dose↑, *BioAv↑, *hepatoP↓,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*Dose∅, *Half-Life∅, *BioAv∅, *BBB↑, *toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
1303- EGCG,    (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation
- in-vitro, EC, NA
TumCP↓, ER-α36↓, cycD1/CCND1↓, ERK↑, Jun↓, BAX↑, Bcl-2↓, cl‑Casp3↑, ROS↑, p38↑,
20- EGCG,    Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
- in-vivo, Liver, NA - in-vivo, Tong, NA
HH↓, Gli1↓, Smo↓, TNF-α↓, COX2/PTGS2↓, *antiOx↑, Hif1a↓, NF-kB↓, VEGF↓, STAT3↓, Bcl-2↓, P53↑, Akt↓, p‑Akt↓, p‑mTOR↓, EGFR↓, AP-1↓, BAX↑, ROS↑, Casp3↑, Apoptosis↑, NRF2↑, *H2O2↓, *NO↓, *SOD↑, *Catalase↑, *GPx↑, *ROS↓,
23- EGCG,    (-)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells
- in-vitro, Chon, SW1353 - in-vitro, Chon, CRL-7891
HH↓, Gli1↓, PTCH1↓, Bcl-2↓, BAX↑, TumCG↓,
668- EGCG,    The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment
- Review, BC, MCF7 - Review, BC, MDA-MB-231
HER2/EBBR2↓, EGFR↓, mtDam↑, ROS↑, PI3K/Akt↓, P53↑, P21↑, Casp3↑, Casp9↑, BAX↑, PTEN↑, Bcl-2↓, hTERT/TERT↓, STAT3↓, TumCCA↑, Hif1a↓,
651- EGCG,    Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications
- Review, Var, NA
ROS↑, p‑AMPK↑, mTOR↓, FAK↓, Smo↓, Gli1↓, HH↓, TumCMig↓, TumCI↓, NOTCH↓, JAK↓, STAT↓, Bcl-2↓, Bcl-xL↓, BAX↑, Casp9↑,
689- EGCG,    EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down regulation of NF-κB and MMP-9
- vitro+vivo, Bladder, SW780
Casp8↑, Casp9↑, Casp3↑, BAX↑, PARP↑, TumVol↓, NF-kB↓, MMP9↓,
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, Var, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27/CDKN1B↑, P21↑,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, Synergy↑, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, Synergy↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?, *antiAll↑,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
6828- EMD,    Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice
- in-vitro, AD, U251
*MMP↑, *ROS↓, *NRF2↑, *HO-1↑, *SOD↑, *Bcl-2↑, *Catalase↑, *BAX↓, *memory↑, *ANXi↓, *Aβ↓, *antiOx↑, *MDA↓,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
1327- EMD,    Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway
- in-vitro, Lung, A549
Cyt‑c↑, Casp2↑, Casp3↑, Casp9↑, ERK↓, Akt↓, ROS↑, MMP↓, Bcl-2↓, BAX↑,
1324- EMD,    Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin
- Review, Var, NA
*toxicity↑, *BioAv↓, Akt↓, ERK↓, ROS↑, MMP↓, Bcl-2↓, BAX↑, TumCCA↑,
1325- EMD,  PacT,    Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo
- vitro+vivo, Lung, A549
TumCP↓, Apoptosis↑, BAX↑, Casp3↑, Bcl-2↓, p‑Akt↓, p‑ERK↓, ChemoSideEff∅, ChemoSen↑,
1326- EMD,    Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells
- in-vitro, Lung, A549
Apoptosis↑, ROS↑, P53↑, BAX↑, ATM↑,
1296- EMD,    Emodin inhibits LOVO colorectal cancer cell proliferation via the regulation of the Bcl-2/Bax ratio and cytochrome c
- in-vitro, CRC, LoVo
BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑,
1330- EMD,    Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway
- in-vitro, Var, NA
tumCV↓, Casp3↑, Casp9↑, MMP↓, Cyt‑c↑, BAX↑, Bax:Bcl2↑,
3460- EP,    Picosecond pulsed electric fields induce apoptosis in HeLa cells via the endoplasmic reticulum stress and caspase-dependent signaling pathways
- in-vitro, Cerv, HeLa
tumCV↓, Apoptosis↑, TumCCA↑, GRP78/BiP↑, GRP94↑, CEBPA↑, CHOP/DDIT3↑, Ca+2↑, Casp12↑, Casp9↑, Casp3↑, Cyt‑c↑, BAX↑, Bcl-2↓, ER Stress↑, MMP↓,

Showing Research Papers: 251 to 300 of 755
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 755

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 5,   antiOx↑, 10,   antiOx⇅, 3,   ARE↑, 1,   Catalase↓, 15,   Catalase↑, 10,   Copper↑, 1,   Fenton↑, 2,   frataxin↑, 1,   GPx↓, 4,   GPx↑, 7,   GPx4↓, 11,   GPx4↑, 1,   GSH↓, 53,   GSH↑, 8,   GSH/GSSG↓, 3,   GSR↑, 2,   GSS↑, 1,   GSSG↓, 1,   GSTs↓, 1,   GSTs↑, 5,   H2O2↑, 8,   HO-1↓, 6,   HO-1↑, 11,   HO-1↝, 1,   Iron↑, 4,   i-Iron↑, 1,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 10,   lipid-P↑, 16,   lipid-P↝, 1,   MDA↓, 6,   MDA↑, 14,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 1,   NQO1↑, 2,   Nrf1↑, 1,   NRF2↓, 18,   NRF2↑, 23,   NRF2⇅, 1,   NRF2↝, 3,   p‑NRF2↓, 1,   Prx↓, 1,   Prx6↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   RNS↑, 2,   ROS?, 5,   ROS↓, 25,   ROS↑, 347,   ROS⇅, 7,   ROS↝, 1,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 4,   mt-ROS↑, 7,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 19,   SOD↑, 11,   SOD1↓, 1,   SOD1↑, 2,   SOD2↓, 3,   SOD2↑, 5,   TAC?, 1,   TAC↓, 1,   TAC↑, 1,   TBARS↑, 2,   Thiols↓, 3,   Trx1↑, 1,   Trx2↓, 1,   TrxR↓, 5,   TrxR1↓, 3,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   IronCh↑, 2,   NCOA4↑, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   BCR↓, 1,   CDC2↓, 9,   CDC2↑, 1,   CDC25↓, 17,   CDC25↑, 1,   p‑CDC25↑, 1,   compI↓, 2,   compIII↓, 1,   compIII↑, 1,   compV↓, 1,   EGF↓, 6,   ETC↓, 4,   HSP60/HSPD1↓, 1,   HSP60/HSPD1↑, 1,   MFN2↑, 1,   mitResp↓, 2,   mitResp↑, 2,   MKK7↓, 1,   mtDam↑, 33,   OCR↓, 6,   OXPHOS↓, 4,   OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 1,   PDH↝, 1,   PHB↓, 1,   PINK1↑, 3,   SIRT3↓, 3,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 5,   5LO↓, 2,   ACC↑, 3,   Acetyl-CoA↓, 1,   ACLY↓, 3,   ACSL4↑, 1,   ALAT↓, 2,   ALAT↝, 1,   ALAT∅, 1,   ALDOA↓, 1,   AMP↑, 1,   AMPK?, 1,   AMPK↓, 2,   AMPK↑, 21,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 17,   ATP∅, 1,   e-ATP↑, 1,   CAIX/CA9↓, 3,   CAIX/CA9↑, 1,   i-Cer↑, 1,   ENO1↓, 1,   FASN↓, 5,   FBI-1↓, 1,   FFA/NEFA↓, 1,   GALNT10↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 2,   GlucoseCon↓, 7,   GlutMet↓, 1,   Glycolysis↓, 25,   GSK‐3β↓, 9,   GSK‐3β↑, 8,   p‑GSK‐3β↓, 5,   H2S↑, 1,   HK1↓, 1,   HK2↓, 16,   HMG-CoA↓, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 9,   lactateProd↑, 1,   LDHA↓, 7,   LDL↓, 3,   MCT4↓, 1,   NAD↝, 1,   NADPH↓, 3,   PCK1↓, 1,   PDK1 / PDPK1↓, 8,   PDKs↓, 1,   PFK↓, 4,   PFKFB4?, 1,   PFKP↓, 1,   PKM2↓, 10,   Pyruv↓, 1,   p‑S6↓, 1,   SIRT1↓, 3,   SIRT1↑, 7,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   TCA?, 1,   TCA↓, 4,   TS↓, 1,   TumCM/A↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↑, 24,   AIF↝, 1,   APAF1↑, 14,   Apoptosis?, 4,   Apoptosis↓, 10,   Apoptosis↑, 369,   Apoptosis↝, 1,   mt-Apoptosis↑, 6,   ASK1↑, 2,   p‑ASK1↑, 1,   BAD?, 1,   BAD↓, 5,   BAD↑, 29,   BAD↝, 1,   Bak↓, 1,   Bak↑, 27,   BAX?, 1,   BAX↓, 17,   BAX↑, 664,   BAX⇅, 2,   BAX↝, 5,   BAX∅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 20,   Bcl-2↓, 504,   Bcl-2↑, 10,   Bcl-2↝, 3,   Bcl-2∅, 2,   cl‑Bcl-2↑, 1,   Bcl-xL↓, 66,   Bcl-xL↑, 2,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 1,   BID↑, 17,   p‑BID↓, 1,   cl‑BID↑, 2,   BIM↓, 1,   BIM↑, 13,   BNIP3?, 1,   BNIP3↓, 1,   BNIP3↑, 5,   BOK↑, 2,   Casp↓, 2,   Casp↑, 40,   Casp↝, 1,   cl‑Casp↑, 1,   cl‑Casp1↑, 1,   Casp10↓, 1,   Casp10↑, 3,   Casp12↑, 6,   Casp12↝, 1,   cl‑Casp12↑, 2,   Casp2↑, 2,   Casp3?, 2,   Casp3↓, 8,   Casp3↑, 313,   Casp3↝, 2,   Casp3∅, 1,   cl‑Casp3↑, 99,   cl‑Casp3⇅, 1,   proCasp3↓, 2,   proCasp3↑, 4,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↑, 2,   Casp7↑, 30,   cl‑Casp7↑, 7,   Casp8↓, 3,   Casp8↑, 67,   cl‑Casp8↑, 17,   proCasp8↑, 4,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 195,   Casp9∅, 1,   p‑Casp9↑, 1,   cl‑Casp9↑, 36,   proCasp9↓, 1,   proCasp9↑, 4,   pro‑Casp9↑, 1,   CellShr↑, 2,   cFLIP↓, 7,   Cupro↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 204,   Cyt‑c↝, 3,   Cyt‑c?, 1,   mt-Cyt‑c↓, 1,   Diablo↑, 8,   DR5↑, 37,   Endon↑, 1,   FADD↑, 11,   Fas↓, 2,   Fas↑, 41,   FasL↓, 1,   FasL↑, 21,   FasL⇅, 1,   Ferroptosis↑, 10,   GranB/GZMB↝, 1,   GSDMD↑, 2,   cl‑GSDMD↑, 1,   GSDME↑, 1,   GSDME-N↑, 2,   HEY1↓, 1,   IAP1↓, 9,   IAP2/BIRC3↓, 3,   ICAD↓, 1,   ICD↑, 3,   iNOS↓, 15,   iNOS↑, 1,   Mcl-1↓, 37,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 15,   MDM2↑, 2,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↓, 1,   MOMP↑, 6,   NAIP↓, 2,   Necroptosis↑, 4,   necrosis↑, 4,   NOXA↑, 6,   p38↓, 5,   p38↑, 32,   p‑p38↓, 5,   p‑p38↑, 10,   Paraptosis↑, 1,   Perforin↝, 1,   PUMA↑, 12,   PUMA⇅, 1,   Pyro↑, 8,   RIP3↑, 3,   p‑RIP3↑, 2,   survivin↓, 71,   survivin↝, 1,   TNFR 1↑, 3,   TRAIL↑, 10,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 2,   TumCD↑, 25,   TUNEL↑, 2,   XIAP↓, 26,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 167,   Akt↑, 6,   Akt↝, 1,   p‑Akt↓, 66,   AKT1↓, 4,   Akt2↓, 1,   AMPKα↑, 1,   BRAF↝, 1,   CaMKII ↓, 2,   Cavin3↓, 1,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 2,   p‑CREB↓, 1,   cSrc↓, 1,   EGFR↓, 34,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   ERK↓, 65,   ERK↑, 15,   p‑ERK↓, 19,   p‑ERK↑, 6,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 12,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 3,   Hippo↓, 1,   Hippo↑, 1,   HRAS↓, 3,   IGF-1R↓, 3,   IGF-1R↑, 1,   IGFR↓, 2,   IKKα↓, 7,   IKKα↑, 2,   p‑IKKα↓, 1,   IκB↓, 1,   IκB↑, 2,   p‑IκB↓, 1,   p‑IκB↑, 1,   JAK↓, 5,   JAK1↓, 5,   JAK1↑, 1,   JAK2↓, 10,   p‑JAK2↓, 2,   JNK↓, 7,   JNK↑, 32,   JNK↝, 1,   p‑JNK↑, 7,   cl‑JNK↑, 1,   LATS1↓, 1,   LIFR/CD118↓, 1,   LIMK1↓, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK?, 1,   MAPK↓, 40,   MAPK↑, 26,   MAPK↝, 2,   p‑MAPK↓, 3,   p‑MAPK↑, 1,   MARK4↓, 1,   MEK↓, 7,   p‑MEK↓, 2,   p‑MEK↑, 1,   MKK4↓, 1,   MKP1↓, 1,   MKP2↓, 1,   Mst1↑, 1,   mTOR↓, 77,   mTOR↑, 3,   mTOR↝, 2,   p‑mTOR↓, 25,   mTORC2↓, 3,   NRAS↓, 1,   p‑p42↑, 1,   p70S6↓, 1,   p70S6↑, 1,   P70S6K↓, 7,   p‑P70S6K↓, 3,   p‑P90RSK↑, 1,   PDE3B↓, 1,   PDGFRA↓, 1,   PI3K↓, 130,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 17,   p‑PI3K↑, 1,   PI3K/Akt↓, 9,   PI3K/Akt↑, 1,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↝, 1,   PIK3CA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 12,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 2,   PTEN↑, 29,   PTEN↝, 2,   Raf↓, 7,   e-Raf↓, 1,   RAS↓, 11,   RAS↑, 1,   RET↓, 1,   Rictor↓, 1,   RIP1↓, 1,   RIP1↑, 1,   RSK2/RPS6KA3/p90RSK2↓, 1,   RTK-RAS↓, 1,   p‑S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 9,   Src↓, 1,   Src↑, 1,   STAT↓, 4,   STAT3↓, 71,   STAT3↑, 4,   p‑STAT3↓, 15,   p‑STAT3↑, 1,   STAT4↑, 1,   STAT5↓, 1,   STAT6↓, 2,   THEM4/CTMP↑, 1,   TSC2↑, 4,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   ATF1↓, 1,   ATF4↓, 1,   ATF4↑, 13,   ATFs↑, 1,   ChrMod↑, 1,   cJun↓, 7,   cJun↑, 5,   p‑cJun↑, 1,   cMyc↓, 37,   cMyc↑, 3,   p‑cMyc↑, 1,   DNMT1↓, 12,   DNMT3A↓, 5,   DNMTs↓, 6,   EZH2↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   FOXO1↓, 3,   FOXO1↑, 3,   FOXO3↓, 2,   FOXO3↑, 2,   FOXO3↝, 1,   p‑FOXO3↓, 2,   FOXO4↓, 1,   H3↓, 3,   p‑H3↓, 1,   ac‑H3↑, 3,   ac‑H4↑, 2,   HATs↓, 4,   HATs↑, 1,   HDAC↓, 22,   HDAC1↓, 7,   HDAC10↑, 1,   HDAC2↓, 4,   HDAC3↓, 4,   HDAC4↓, 1,   HDAC8↓, 2,   HMTs↓, 1,   IRF1↑, 1,   KCNQ1OT1↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-122-5p↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 3,   miR-17↓, 1,   miR-195↑, 1,   miR-21↓, 4,   miR-21↑, 1,   miR-221↓, 1,   miR-224↓, 1,   miR-25-5p↑, 1,   miR-27a-3p↓, 2,   miR-27a-3p↑, 1,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-320a↓, 1,   miR-340↓, 1,   miR-34a↓, 2,   miR-34a↑, 8,   miR-375↓, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-497↑, 1,   miR-548ah-5p↑, 1,   miR-590-3p↑, 1,   Myc↓, 5,   MYCN↓, 1,   NDRG1↑, 1,   NR1D2↓, 1,   OCT4↓, 9,   OCT4↑, 1,   other?, 1,   other↓, 4,   other↑, 2,   other↝, 6,   PAX2↓, 1,   PhotoS↑, 2,   SALL4↓, 1,   Shc↓, 1,   sonoS↑, 2,   SOX2↓, 7,   SOX4↑, 1,   TCF-4↓, 1,   TET3↑, 1,   TFE3↑, 1,   tumCV?, 1,   tumCV↓, 108,   tumCV↑, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 35,   CRT↑, 1,   EDEM↑, 1,   eIF2α↓, 2,   eIF2α↑, 8,   p‑eIF2α↓, 1,   p‑eIF2α↑, 4,   ER Stress↓, 2,   ER Stress↑, 52,   GRP78/BiP?, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 14,   GRP94↑, 2,   HSP27↓, 4,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 4,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 8,   HSP90↑, 2,   IRE1↑, 4,   PERK↑, 10,   p‑PERK↑, 2,   Proteasome↓, 2,   UPR↑, 9,   XBP-1↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 4,   ATG5↑, 10,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 26,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 4,   LC3A↑, 1,   LC3B↑, 2,   LC3B-II↑, 3,   LC3I↓, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 20,   LC3s↑, 3,   MitoP↑, 1,   p62↓, 9,   p62↑, 4,   PARK2↑, 3,   RUBCN↓, 1,   SESN2↑, 3,   TumAuto?, 1,   TumAuto↓, 1,   TumAuto↑, 48,   TumAuto⇅, 1,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1,   ATM↑, 4,   p‑ATM↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   DFF45↓, 2,   DFF45↑, 1,   DNA-PK↑, 1,   DNAdam↓, 2,   DNAdam↑, 81,   DNArepair↓, 7,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC3↑, 1,   ERCC4/XPF↓, 1,   FEN1↓, 1,   hTERT/TERT↓, 12,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 3,   P53?, 1,   P53↓, 4,   P53↑, 187,   P53⇅, 1,   P53↝, 3,   p‑P53↑, 9,   p53 Wildtype↓, 1,   PARP↓, 5,   PARP↑, 34,   PARP↝, 1,   p‑PARP↑, 4,   cl‑PARP↓, 3,   cl‑PARP↑, 115,   cl‑PARP∅, 1,   PARP1↓, 1,   PARP1↑, 4,   cl‑PARP1↑, 5,   PCNA↓, 45,   PCNA↑, 1,   RAD51↓, 1,   RAD51↑, 1,   SIRT6↓, 1,   SMG1↑, 1,   Telomerase↓, 12,   TOP1↓, 3,   TOP1↝, 1,   TOP2↓, 7,   TP53↓, 3,   TP53↑, 1,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 12,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CDK1↓, 30,   CDK1↑, 3,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 39,   CDK2↑, 4,   p‑CDK2↓, 2,   CDK4↓, 48,   CDK4↑, 2,   CDK4↝, 1,   p‑CDK4↓, 1,   CDK6↓, 21,   CDK6↑, 3,   CHK1↓, 2,   CHK1↑, 2,   p‑CHK1↑, 2,   Chk2↓, 2,   Chk2↑, 1,   p‑Chk2↑, 1,   ChrCon↑, 2,   Cyc↓, 4,   Cyc↝, 1,   cycA1/CCNA1↓, 13,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 41,   CycB/CCNB1↑, 4,   cycD1/CCND1↓, 107,   cycD1/CCND1↑, 4,   cycD1/CCND1↝, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 22,   cycE/CCNE↑, 2,   cycE1↓, 3,   cycF↓, 1,   cycF↑, 1,   E2Fs↓, 3,   FBXO5/EMI1↓, 1,   GADD45A↑, 3,   Ki-67↓, 39,   MAD↓, 1,   mitA↓, 1,   p19↑, 1,   P21?, 1,   P21↓, 8,   P21↑, 104,   P21↝, 2,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 39,   PLK1↓, 1,   pRB↓, 2,   pRB↑, 2,   p‑pRB↓, 2,   RB1↓, 2,   RB1↑, 3,   cl‑RB1↓, 1,   Securin↓, 1,   TAp63α↑, 1,   TumCCA?, 2,   TumCCA↓, 8,   TumCCA↑, 267,   WEE1↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 2,   ALDH↓, 3,   ALDH1A1↓, 4,   BMI1↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 5,   CD133↑, 1,   CD24↓, 2,   CD34↓, 1,   CEBPA↑, 1,   cFos↓, 8,   CSCs↓, 28,   Diff↑, 2,   EIF4E↓, 2,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli1↓, 10,   HH↓, 7,   HMGCR↓, 1,   IGF-1↓, 10,   p‑IGF-1↓, 1,   IGF-2↓, 1,   IGFBP3↑, 4,   IGFBP7↑, 1,   Jun↓, 1,   Ki-67↓, 39,   Let-7↑, 3,   MCM2↓, 1,   mTORC1↓, 8,   Nanog↓, 9,   Nanog↑, 1,   Nestin↓, 1,   NICD↓, 1,   NOTCH↓, 11,   NOTCH↑, 1,   NOTCH⇅, 1,   NOTCH1↓, 14,   NOTCH1↑, 1,   NOTCH2↓, 1,   NOTCH3↓, 3,   OGFr↑, 2,   PCLAF↓, 1,   circ‑PLEKHM3↑, 1,   PTCH1↓, 3,   SAL↑, 1,   Shh↓, 8,   Smo↓, 6,   Sufu↑, 1,   TAZ↓, 1,   TumCG?, 2,   TumCG↓, 116,   TumCG↑, 4,   TumCP?, 2,   TumCP↓, 216,   TumCP↑, 5,   tyrosinase↓, 2,   URGCP/URG4↓, 1,   Wnt?, 1,   Wnt↓, 36,   Wnt↑, 1,   Wnt/(β-catenin)↓, 4,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 11,   AP-1↝, 1,   AXL↓, 1,   Ca+2↓, 3,   Ca+2↑, 42,   Ca+2↝, 3,   i-Ca+2↑, 3,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↑, 4,   Cal9↑, 1,   CCN2/CTGF↓, 2,   Cdc42↑, 1,   COL1↓, 2,   COL3A1↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 9,   E-cadherin↑, 51,   EMT?, 1,   EMT↓, 64,   EMT↑, 3,   EpCAM↓, 3,   F-actin↓, 1,   FAK↓, 18,   Fibronectin↓, 4,   GLI2↓, 3,   hnRNPA1↓, 1,   ITGA5↓, 1,   ITGB1↓, 3,   ITGB3↓, 2,   KRAS↓, 3,   LAMs↓, 1,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 3,   MET↑, 2,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 4,   MMP16↓, 1,   MMP2↓, 89,   MMP2↝, 1,   MMP3↓, 8,   MMP7↓, 9,   MMP9↓, 109,   MMPs↓, 28,   MRGPRF↓, 1,   MTA1↓, 2,   N-cadherin↓, 33,   NFAT↑, 1,   p44↓, 1,   p‑p44↓, 1,   p‑p44↑, 1,   PAI-1/SERPINE1↑, 1,   PAK1↓, 1,   PAK1↑, 1,   PDGF↓, 5,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 2,   Slug?, 1,   Slug↓, 7,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 2,   SMAD4↑, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 23,   TET1↑, 3,   TGF-β↓, 16,   TGF-β↑, 2,   TIMP1↓, 5,   TIMP1↑, 12,   TIMP2↓, 4,   TIMP2↑, 16,   TIMP3↑, 1,   TRIB3↑, 1,   TSC1↑, 1,   TSP-1↑, 4,   TumCA↓, 2,   TumCI?, 2,   TumCI↓, 89,   TumCI↑, 1,   TumCMig?, 1,   TumCMig↓, 93,   TumCMig↑, 1,   TumMeta↓, 57,   TumMeta↑, 5,   TumPF↓, 2,   Twist↓, 17,   uPA↓, 23,   uPAR↓, 2,   Vim↓, 39,   Zeb1↓, 8,   Zeb1↑, 1,   ZEB2↓, 2,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 39,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 78,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   ECM/TCF↓, 1,   Endoglin↑, 2,   eNOS↓, 2,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 52,   Hif1a↑, 1,   LOX1↓, 2,   NO↓, 4,   NO↑, 1,   VCAM-1↓, 4,   VEGF↓, 98,   VEGF↝, 1,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 15,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   BBB∅, 1,   CellMemb↓, 1,   CLDN2↓, 2,   EPR↑, 3,   GLUT1↓, 9,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   MMP↓, 192,   MMP↑, 1,   MMP↝, 1,   MPT↑, 4,   TRPM7↓, 2,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   B2M↓, 1,   CB2 / CNR2↑, 3,   CCR7↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 9,   CD8+↑, 3,   cDC2↓, 3,   p‑cDC2↑, 1,   COX2/PTGS2↓, 65,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL12↓, 1,   CXCR2↓, 2,   CXCR3↓, 1,   CXCR4↓, 11,   DR4↑, 11,   DR6↑, 1,   FOXP3↓, 2,   FOXP3↑, 2,   Gal-3↓, 1,   HLA↑, 1,   HMGB1↓, 3,   HMGB1↑, 1,   ICAM-1↓, 5,   IFN-γ↓, 4,   IFN-γ↑, 3,   IL1↓, 5,   IL1↑, 1,   IL10↓, 6,   IL10↑, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 13,   IL1β↑, 3,   IL2↓, 2,   IL2↑, 4,   IL4↓, 1,   IL4↑, 1,   IL6↓, 40,   IL6↑, 1,   IL6↝, 1,   IL7↓, 1,   IL8↓, 10,   Imm↑, 14,   Imm↝, 2,   Inflam↓, 27,   Inflam↝, 1,   LTA/TNF-β↓, 1,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 4,   MDSCs↓, 1,   MIP-1β↑, 1,   NAF1↓, 1,   NF-kB?, 1,   NF-kB↓, 151,   NF-kB↑, 7,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 1,   NOD1↓, 1,   p65↓, 9,   p‑p65↑, 1,   PD-1↓, 1,   PD-L1↓, 8,   PD-L1↑, 1,   PGE2↓, 9,   PSA↓, 8,   PSA↝, 1,   RAGE↓, 2,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 3,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 5,   TNF-α↓, 41,   TNF-α↑, 10,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 5,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 15,   AR↝, 1,   ER-α36↓, 3,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,   Estro↝, 1,   PPARα↓, 1,   PPARα↑, 1,   cl‑PPARα↓, 1,   PPARγ↓, 3,   PPARγ↑, 5,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4,   AKR1B10↓, 1,   BioAv↓, 33,   BioAv↑, 33,   BioAv↝, 6,   BioEnh↑, 1,   ChemoSen?, 2,   ChemoSen↓, 3,   ChemoSen↑, 136,   ChemoSen↝, 1,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 5,   CYP1A1↑, 2,   CYP1A2↓, 2,   CYP1B1↓, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 5,   Dose↝, 52,   Dose∅, 9,   eff↓, 79,   eff↑, 93,   eff↝, 10,   eff∅, 1,   GSTA1↑, 2,   Half-Life↓, 8,   Half-Life↝, 5,   Half-Life∅, 2,   MDR1↓, 5,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 19,   P-gp/ABCB1⇅, 1,   P450↓, 4,   RadioS?, 1,   RadioS↑, 37,   selectivity?, 2,   selectivity↓, 1,   selectivity↑, 100,   selectivity∅, 2,   Synergy?, 1,   Synergy↑, 107,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 4,   ALAT↓, 2,   ALAT↝, 1,   ALAT∅, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 15,   AR↝, 1,   AST↓, 2,   AST↝, 1,   AST∅, 1,   B2M↓, 1,   BRAF↝, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 2,   CRP↓, 2,   E6↓, 3,   E7↓, 3,   EGFR↓, 34,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   ERα/ESR1↓, 1,   EZH2↓, 1,   Ferritin↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 12,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 12,   IL6↓, 40,   IL6↑, 1,   IL6↝, 1,   KRAS↓, 3,   LDH?, 1,   LDH↓, 14,   LDH↑, 8,   LDH↝, 2,   i-LDH↓, 1,   Maspin↑, 2,   Myc↓, 5,   PD-L1↓, 8,   PD-L1↑, 1,   PSA↓, 8,   PSA↝, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TP53↓, 3,   TP53↑, 1,   TRIB3↑, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 61,   AntiCan∅, 1,   antiCG↓, 1,   antiNeop↑, 3,   AntiTum↓, 2,   AntiTum↑, 25,   cachexia↓, 1,   cardioP↑, 9,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 30,   chemoPv↑, 15,   ChemoSideEff↓, 6,   ChemoSideEff∅, 1,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 14,   Mucositis↓, 1,   neuroP↑, 6,   NKG2D↑, 1,   OS↑, 10,   Pain↓, 2,   PFS↑, 1,   Pin1↓, 3,   QoL↑, 2,   QoL∅, 1,   radioP↑, 6,   Remission↑, 1,   RenoP↑, 11,   Risk↓, 12,   Sleep↑, 1,   toxicity?, 1,   toxicity↓, 22,   toxicity↑, 4,   toxicity↝, 8,   toxicity∅, 1,   TumNum↓, 1,   TumVol↓, 30,   TumVol↑, 1,   TumW↓, 17,   Weight↑, 2,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiFungal↑, 1,   Bacteria↓, 3,   GutMicro↑, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 7,  
Total Targets: 1201

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 4,   antiOx↑, 91,   ARE↑, 2,   Bil↓, 1,   Catalase↓, 2,   Catalase↑, 54,   GPx↓, 1,   GPx↑, 42,   GPx4↑, 2,   GSH↓, 1,   GSH↑, 49,   GSH/GSSG↑, 1,   GSR↑, 7,   GSTs↓, 2,   GSTs↑, 9,   H2O2↓, 5,   HDL↑, 3,   HO-1?, 2,   HO-1↓, 2,   HO-1↑, 26,   Iron↓, 2,   Keap1↓, 3,   Keap1↑, 1,   lipid-P↓, 39,   MDA?, 1,   MDA↓, 35,   MDA↑, 2,   MPO↓, 4,   NADH↓, 1,   NOX4↓, 1,   NQO1↑, 3,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 56,   RNS↓, 4,   ROS?, 1,   ROS↓, 113,   ROS↑, 6,   ROS∅, 1,   SOD↓, 3,   SOD↑, 72,   SOD1↑, 2,   SOD2↑, 3,   TAC↑, 5,   TBARS↓, 1,   Trx↑, 1,   uricA↓, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   FIS1↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mtDam↓, 4,   PGC-1α↓, 2,   PGC-1α↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↝, 1,   ACSL4↓, 1,   ALAT↓, 14,   AMPK↓, 1,   AMPK↑, 8,   p‑AMPK↑, 1,   ATP↓, 2,   ATP↑, 3,   DGAT1↓, 1,   FASN↓, 1,   GAPDH↑, 1,   glucose↓, 4,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   H2S↑, 1,   HMG-CoA↓, 2,   LDHA↑, 1,   LDL↓, 4,   lipidLev↓, 3,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 2,   NADPH↑, 1,   PLA2↓, 1,   SIRT1↑, 9,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   APAF1↓, 2,   Apoptosis↓, 27,   Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 3,   BAX↓, 67,   BAX↑, 8,   Bax:Bcl2↓, 1,   Bcl-2↓, 9,   Bcl-2↑, 40,   Bcl-2∅, 1,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   Casp1↓, 2,   Casp12↓, 2,   Casp3↓, 41,   Casp3↑, 2,   cl‑Casp3↓, 10,   Casp8↓, 3,   Casp9↓, 12,   cl‑Casp9↓, 4,   Cyt‑c↓, 12,   Cyt‑c↑, 3,   Fas↓, 3,   FasL↓, 1,   Ferroptosis↓, 4,   iNOS↓, 21,   iNOS↑, 1,   MLKL↓, 1,   p38↓, 3,   p38↑, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 7,   p‑Akt↓, 2,   p‑Akt↑, 8,   Akt2↓, 1,   CaMKII ↓, 1,   CREB↑, 2,   p‑CREB↑, 3,   ERK↓, 2,   ERK↑, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   IκB?, 1,   IκB↑, 1,   JAK↓, 2,   JAK2↑, 1,   JNK↓, 7,   JNK↑, 2,   p‑JNK↓, 1,   MAPK↓, 5,   MAPK↑, 2,   Mst1↓, 2,   mTOR↓, 1,   mTOR↑, 4,   p‑mTOR↑, 2,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 2,   PI3K↑, 6,   PKA↑, 1,   PKCδ↑, 1,   PP2A↑, 1,   p‑PTEN↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT3↓, 1,   STAT3↑, 2,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 6,   ATF4↓, 2,   cJun↓, 2,   p‑cJun↓, 2,   cMyc↓, 1,   HDAC↓, 2,   HDAC3↓, 1,   other↓, 3,   other↑, 3,   other↝, 5,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 4,   IRE1↓, 2,   PERK↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 1,   LC3A↑, 1,   LC3II↓, 1,   LC3II↑, 2,   MitoP↑, 1,   p62↓, 3,   p62↑, 3,   PARK2↑, 2,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 7,   p16↓, 1,   P53↓, 6,   P53↑, 1,   PARP↓, 1,   cl‑PARP↓, 1,   PCNA↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 2,   P21↑, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   Diff↑, 1,   IGF-1↑, 1,   Ki-67↓, 1,   neuroG↑, 2,   TumCP↓, 2,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 2,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↑, 1,   Ca+2↝, 1,   cal2↓, 1,   Cartilage↑, 1,   COL1↓, 1,   COL1↑, 1,   E-cadherin↓, 1,   MLC2/MYL9↝, 1,   MMP1↓, 1,   MMP13↓, 2,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 5,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 3,   TregCell↑, 1,   TumCI↓, 1,   TXNIP↓, 1,   Zeb1↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   E-sel↓, 1,   HIF-1↓, 1,   Hif1a↓, 1,   NO?, 1,   NO↓, 16,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 8,   BBB↝, 2,   BBB∅, 2,   CLDN1↓, 1,   CLDN4↑, 1,   GastroP↑, 5,   GLUT1↑, 1,   GLUT2↑, 2,   GLUT3↑, 2,   GLUT4↑, 1,   IBI↑, 2,   MMP↓, 2,   MMP↑, 12,   MMP∅, 1,   MPT↑, 1,   MUC5AC↓, 1,   OCLN↓, 1,   OCLN↑, 2,   OCLN↝, 1,   TJ↑, 4,   TRPA1↑, 1,   TRPV1↑, 1,   ZO-1↓, 2,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CCL11↓, 1,   CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 32,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 8,   IL10↑, 3,   IL12↓, 1,   IL13↑, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 28,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 31,   IL6↑, 1,   IL8↓, 4,   Imm↓, 1,   Imm↑, 5,   Inflam↓, 99,   Inflam↑, 1,   IRF3↓, 1,   MCP1/CCL2↓, 2,   MyD88↓, 2,   NeuroI↓, 3,   NF-kB?, 1,   NF-kB↓, 40,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NK cell↑, 1,   NLRP3↓, 6,   p65↓, 1,   PGE2↓, 12,   PGE2↑, 1,   PSA∅, 1,   RAGE↓, 4,   RANTES↓, 1,   SOCS-3↓, 1,   TLR2↓, 1,   TLR4↓, 8,   TNF-α↓, 50,   TNF-α↑, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 3,   AChE↓, 20,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 13,   BDNF⇅, 1,   ChAT↑, 2,   GABA↑, 1,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 3,   PSD95↑, 2,   SNAP25↑, 2,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 2,   Aβ↓, 18,   Aβ42↓, 4,   BACE/β-secretase↓, 9,   IDE↑, 1,   tau↓, 4,   p‑tau↓, 6,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 4,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 36,   BioAv↑, 35,   BioAv↝, 13,   BioAv∅, 1,   BioEnh↑, 3,   CompStab↑, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 1,   Dose↑, 1,   Dose↝, 14,   Dose∅, 1,   eff↓, 5,   eff↑, 9,   GSTA1↑, 2,   Half-Life↑, 2,   Half-Life↝, 9,   Half-Life∅, 1,   P-gp/ABCB1↓, 2,   P450↓, 3,   P450↝, 1,   selectivity↑, 2,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 14,   ALP↓, 5,   AST↓, 15,   Bil↓, 1,   BMD↑, 1,   BP↓, 4,   BUN?, 1,   BUN↓, 1,   CEA↓, 1,   colonLen↑, 1,   creat↓, 3,   CRP↓, 6,   hs-CRP↓, 1,   IL6↓, 31,   IL6↑, 1,   LDH↓, 5,   NOS2↓, 1,   PSA∅, 1,   RAGE↓, 4,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 13,   AntiArt↑, 7,   AntiCan↑, 15,   antiCG↑, 2,   antiD↓, 1,   AntiDiabetic↑, 20,   AntiTum↓, 1,   AntiTum↑, 4,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 39,   CardioT↓, 1,   chemoP↑, 7,   chemoPv↑, 4,   cognitive↑, 20,   diuretic↑, 2,   hepatoP↓, 2,   hepatoP↑, 37,   Learn↑, 4,   memory↑, 22,   motorD↑, 6,   Mucositis↓, 2,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 67,   Obesity↓, 4,   Pain↓, 4,   radioP↑, 4,   RenoP↓, 1,   RenoP↑, 14,   Risk↓, 2,   Strength↑, 1,   Stroke↓, 8,   toxicity?, 1,   toxicity↓, 22,   toxicity↑, 4,   toxicity↝, 4,   toxicity∅, 7,   Weight∅, 1,   Wound Healing↑, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 9,   AntiFungal↑, 5,   AntiP↓, 1,   AntiP↑, 3,   AntiViral↑, 10,   Bacteria↓, 15,   Bacteria↑, 1,   Diar↓, 3,   GutMicro↑, 10,   Inf↓, 1,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 6,  
Total Targets: 475

Scientific Paper Hit Count for: BAX, Apoptosis regulator BAX
33 Silver-NanoParticles
27 Quercetin
25 Curcumin
20 Thymoquinone
19 Luteolin
17 Baicalein
15 Apigenin (mainly Parsley)
12 Allicin (mainly Garlic)
12 Propolis -bee glue
12 EGCG (Epigallocatechin Gallate)
11 Emodin
11 Lycopene
10 Sulforaphane (mainly Broccoli)
10 Betulinic acid
10 Fisetin
9 Ashwagandha(Withaferin A)
9 Berberine
9 Kaempferol
9 Matrine
9 Resveratrol
8 Eugenol
8 Ferulic acid
8 Magnetic Fields
8 Graviola
8 Isobavachalcone
8 Juglone
8 Licochalcone A
8 Silymarin (Milk Thistle) silibinin
8 Shikonin
7 Cisplatin
7 Melatonin
7 Carvacrol
7 D-limonene
7 Garcinol
7 Hyperoside
7 Magnolol
7 Phenethyl isothiocyanate
6 Artemisinin
6 Radiotherapy/Radiation
6 Capsaicin
6 Chrysin
6 Ellagic acid
6 Gallic acid
6 Honokiol
6 isoorientin
6 Licorice
6 Morin
6 Nimbolide
5 5-fluorouracil
5 Alpha-Lipoic-Acid
5 Beta-Caryophyllene
5 Benzyl isothiocyanate
5 Cinnamon
5 Formononetin
5 Gambogic Acid
5 Geraniol
5 Hibiscus sabdariffa
5 Isorhamnetin
5 Ivermectin
5 Rosmarinic acid
4 Astragalus
4 Andrographis
4 Isovitexin
4 Astaxanthin
4 Bufalin/Huachansu
4 Boron
4 Boswellia (frankincense)
4 Caffeic acid
4 Carnosic acid
4 chitosan
4 Crocetin
4 Paclitaxel/Taxol
4 Evodiamine
4 Ginkgolide B
4 Indole-3-carbinol
4 Isoliquiritigenin
4 Moringa oleifera
4 Urolithin
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Photodynamic Therapy
3 Gemcitabine (Gemzar)
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Chemotherapy
3 α-Bisabolol / Chamomile oil
3 Thymol-Thymus vulgaris
3 Chlorogenic acid
3 Docetaxel
3 Ursolic acid
3 Dandelion Root
3 Eurycomanone
3 Ginkgetin
3 HydroxyTyrosol
3 isoquercitrin
3 L-Theanine
3 methylseleninic acid
3 Oleuropein
3 Patchouli Oil (Pogostemon cablin)
3 Phycocyanin
3 Piperlongumine
3 Parthenolide
3 Aflavin-3,3′-digallate
2 tamoxifen
2 Allyl isothiocyanate
2 Metformin
2 immunotherapy
2 beta-glucans
2 Berbamine
2 Biochanin A
2 borneol
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Hydroxycinnamic-acid
2 Carvone
2 Polyphenols
2 Chlorella (Chlorella vulgaris)
2 Cynaropicrin
2 Ginkgolic acids
2 Ginger/6-Shogaol/Gingerol
2 Gossypol/AT-101
2 Rutin
2 doxorubicin
2 Vitamin C (Ascorbic Acid)
2 Lactobacillus
2 Laetrile B17 Amygdalin
2 low dose naltrexone
2 Lemongrass Extract/Citral
2 Linalool
2 Lutein
2 Mangiferin
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Naringin
2 Propyl gallate
2 Piperine
2 Plumbagin
2 Pterostilbene
2 Rauwolfia serpentina/Indian Snakeroot
2 salinomycin
2 Selenium
2 Spirulina(Arthrospira/Limnospira)
2 Selenite (Sodium)
2 Vitamin K2
2 Vitexin
1 1,8-Cineole
1 Coenzyme Q10
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Angelica archangelica / Garden Angelica
1 Aspirin
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 Aloe anthraquinones
1 epirubicin
1 Brucea javanica
1 Bromelain
1 Black turtle bean
1 Bullatacin
1 Butyrate
1 Cat’s Claw
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chaetocin
1 Prebiotic
1 Chlorophyllin
1 Citicoline, CDP-Choline
1 Citric Acid
1 Cranberry
1 Copper and Cu NanoParticles
1 Dichloroacetate
1 Date Fruit Extract
1 Disulfiram
1 Electrical Pulses
1 Fenbendazole
1 Flaxseed/Linseed
1 carboplatin
1 olaparib/LYNPARZA
1 Ginkgo biloba
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Hydrogen Gas
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Hyperthermia
1 iodine
1 Isothiocyanates
1 itraconazole
1 lambertianic acid
1 Lapachol
1 SDG/lignans
1 MCT, metronomic chemo
1 Modified Citrus Pectin
1 Methyl Jasmonate
1 Magnetic Field Rotating
1 Moringin
1 Methylglyoxal
1 Zeolite
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 Neem
1 Marjoram (Origanum majorana)
1 Phenylbutyrate
1 sericin
1 Purple Corn / Purple Maize
1 Psoralidin
1 buckwheat sprouts
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 Auranofin
1 Salvia miltiorrhiza
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 triptolide
1 Vitamin D3
1 VitK3,menadione
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:26  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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