TumAuto Cancer Research Results

TumAuto, Tumor autophagy: Click to Expand ⟱
Source: HalifaxProj(activate)
Type:
Autophagy genes, including Atg3, Atg5, Atg6, Atg7, Atg10, Atg12, and Atg17.
Tumor autophagy refers to the process by which cancer cells degrade and recycle cellular components through autophagy, a cellular mechanism that helps maintain homeostasis and respond to stress. Autophagy can have dual roles in cancer, acting as both a tumor suppressor and a promoter, depending on the context.
Authophagy is the process used by cancer cells to “self-eat” to survive. Authophagy can be both good and bad. If authophagy is prolonged this will become a lethal process to cancer. On the other hand, for a short while (e.g. during chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive.
For example, Chloroquine is a blocker of autophagy and has been used in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy.
Scientific Papers found: Click to Expand⟱
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, Var, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2/PTGS2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
5609- NaHCO3,    Alkalization of cellular pH leads to cancer cell death by disrupting autophagy and mitochondrial function
- in-vitro, Var, NA
eff↑, e-pH↑, MMP↓, OXPHOS↝, AMP↑, TumAuto↑, MPT↑, mtDam↑,
1801- NarG,    A Narrative Review on Naringin and Naringenin as a Possible Bioenhancer in Various Drug-Delivery Formulations
- Review, Var, NA
AntiCan↓, CYP19↓, PI3K↓, Akt↓, TumAuto↑, Synergy↑, BioEnh↑,
6490- Nimb,    Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer
- in-vitro, Oral, SCC4
PI3K↓, Akt↓, GSK‐3β↑, MMP↓, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, TumAuto↑, Beclin-1/ATG6↓, p62↑, PI3K↓, chemoPv↑,
4976- Nimb,    Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition
- vitro+vivo, PC, NA
ROS↑, Apoptosis↑, TumAuto↑, TumCP↓, TumCMig↓, TumCI↓, EMT↓, Dose↓, selectivity↑, Akt↓, eff↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓,
8426- OM,    Origanum majorana Ethanolic Extract Promotes Colorectal Cancer Cell Death by Triggering Abortive Autophagy and Activation of the Extrinsic Apoptotic Pathway
- in-vitro, CRC, HT-29 - in-vitro, Colon, Caco-2
TumCP↓, tumCV↓, mitA↑, DNAdam↑, Casp3↑, Casp7↑, survivin↓, TumAuto↑,
8443- OM,    Natural Remedies for Gut Health: The Role of Plant Extracts in Combating Inflammatory Bowel Disease and Colon Cancer
- Review, IBD, NA - Review, Colon, NA
AntiCan↑, TumAuto↑, AIF↑, tumCV↓, TumCCA↑, *NF-kB?, ROS↑, TumCP↓, TumMeta↓, P53↑, BAX↑,
9045- PatchO,    Patchouli alcohol triggers autophagic cell death in non-small cell lung cancer cells through targeting GNAI1 to dissociate the GNAI1/ARRB1 complex
- vitro+vivo, NSCLC, H1299 - in-vitro, Lung, A549
TumAuto↑, toxicity↓, GNAI1↓, ERK↓, JAK2↓, STAT3↓, mTOR↓, eff↝, TumVol↓, toxicity↓, BioAv↑,
2059- PB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA
TumAuto↑, ROS↑, ER Stress↑, TumCG↓, toxicity↓,
2076- PB,    Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
TumCP↓, TumAuto↑, Apoptosis↑, ER Stress↑, BID↑, CHOP/DDIT3↑, PDI↑, IRE1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, LC3B↑, Beclin-1/ATG6↑, other↝, other↝,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, Synergy↑, Synergy↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
4946- PEITC,    Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Apoptosis↑, TumAuto↑, ROS↑, OXPHOS↓, ATP↓, selectivity↑, ETC↓, eff↓, eff↓, BAX↑,
4921- PEITC,    The Potential Use of Phenethyl Isothiocyanate for Cancer Prevention
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, HDAC↓, Risk↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4925- PEITC,    PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells
- in-vitro, OS, NA
tumCV↓, TumCP↓, TumCCA↑, GSH↓, ROS↑, Ferroptosis↑, Apoptosis↑, TumAuto↑, MAPK↑, TumCG↓, Dose⇅,
5218- PG,    Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy
- in-vitro, HCC, Hep3B
TumCP↓, Apoptosis↑, ROS↑, TumAuto↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, BAD↑, Bcl-2↓, toxicity↓, hepatoP↑, GSH↓,
9016- Phyco,    Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy
- vitro+vivo, PC, PANC1 - in-vitro, PC, Capan1 - in-vitro, Liver, HepG2 - in-vitro, Lung, H460 - in-vitro, Pca, DU145
TumCP↓, TumCCA↑, Beclin-1/ATG6↑, p38↑, JNK↑, ERK↓, PI3K↓, Akt↓, mTOR↓, selectivity↑, Dose↝, toxicity↓, TumW↓, TumVol↓, TumAuto↑,
9011- Phyco,    Phycocyanin: A Potential Drug for Cancer Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Imm↑, *RenoP↑, *hepatoP↑, Synergy↑, EMT↓, TumCCA↑, P21↑, cycE/CCNE↓, CDK2↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, Bax:Bcl2↑, MMP↓, ROS↑, CD59↑, Fas?, IL1β↓, IL2↓, IFN-γ↓, TNF-α↓, JAK3↓, STAT3↓, IL4↑, COX2/PTGS2↓, PGE2↓, MMP9↓, MMP2↓, MMP9↓, TIMP2↓, Vim↓, COL1↓, E-cadherin↑, MDR1↓, AP-1↓, ChemoSen↑, chemoP↑, RadioS↑, TumAuto↑,
5214- PI,    Piperine induces autophagy of colon cancer cells: Dual modulation of AKT/mTOR signaling pathway and ROS production
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW48 - in-vitro, CRC, SW-620
TumCP↓, TumAuto↑, Akt↓, mTOR↓, ROS↑,
5161- PLB,    Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
- in-vitro, SCC, SCC25
TumCCA↑, Apoptosis↑, TumAuto↑, Bcl-2↓, Bcl-xL↓, BAX↑, PI3K↓, Akt↓, mTOR↓, GSK‐3β↓, MAPK↓, ROS↑, eff↓, CDC2↓, CycB/CCNB1↓, P21↑, p27/CDKN1B↑, P53↑, Casp9↑, Casp3↑,
4968- PSO,    Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
- in-vitro, Cerv, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiDiabetic↑, *Bacteria↓, AntiTum↑, CSCs↓, ROS↑, TumAuto↑, Apoptosis↑, ChemoSen↑, RadioS↑, BioAv↓, *cardioP↑, *ROS↓, *LDH↓, TumCP↓, TRAIL⇅, TumCMig↓, EMT↓, NF-kB↓, P53↑, Casp3↑, NOTCH↓, CSCs↓, angioG↓, VEGF↓, Ki-67↓, CD31/PECAM-1↓, TRAILR↑, MMP↓, BioAv↓, BioAv↑,
4967- PSO,    Psoralidin's Anti-Cancer Mechanisms: A Technical Guide
- Review, Var, NA
NF-kB↓, PI3K↓, Akt↓, ITGB1↓, FAK↓, BAX↑, Casp3↑, Apoptosis↑, Bcl-2↓, DR5↑, TumCCA↑, TumAuto↑, TumMeta↓,
1993- PTL,    Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer
- in-vitro, Cerv, HeLa
tumCV↓, TumAuto↑, Casp3↑, BAX↑, Beclin-1/ATG6↑, ATG3↑, ATG5↑, Bcl-2↓, mTOR↓, PI3K↓, Akt↓, PTEN↑, ROS↑, MMP↓,
4704- PTS,  Cisplatin,    Pterostilbene Sensitizes Cisplatin-Resistant Human Bladder Cancer Cells with Oncogenic HRAS
- in-vitro, Bladder, NA
PI3K↓, mTOR↓, P70S6K↓, MEK↑, ERK↑, ChemoSen↑, TumAuto↑,
63- QC,    Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
- in-vitro, Pca, NA
RAGE↓, PI3K↓, mTOR↓, Akt↓, Apoptosis↑, TumAuto↑, ChemoSen↑,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
- Review, Var, NA
tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2/PTGS2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,
2341- QC,    Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
MMP2↓, MMP9↓, VEGF↓, Glycolysis↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, TumAuto↑, Akt↓, mTOR↓, TumMeta↓, MMP3↓, eff↓, GlucoseCon↓, lactateProd↓, TumAuto↑, LC3B-II↑,
882- RES,    Resveratrol: A Double-Edged Sword in Health Benefits
- Review, Var, NA
AntiTum↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↑, NAF1↓, NRF2↑, ROS↑, Apoptosis↑, HDAC↓, TumCCA↑, TumAuto↑, angioG↓, iNOS↓,
323- Sal,  AgNPs,    Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy
- in-vitro, BC, MDA-MB-231 - in-vitro, Ovarian, A2780S
TumCD↑, LDH↓, MDA↑, SOD↓, ROS↑, GSH↓, Catalase↓, MMP↓, P53↑, P21↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Apoptosis↑, TumAuto↑,
4898- Sal,    Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
- Review, Var, NA
CSCs↓, AntiCan↑, ChemoSen↑, RadioS↑, Wnt↓, MAPK↓, TumAuto↑, ATP↓, ROS↑, DNAdam↑, ER Stress↑, CSCsMark↓, Iron↑, *toxicity↝,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp/ABCB1↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
- in-vitro, Var, NA
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, Synergy↑,
4906- Sal,    A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)
- Review, BC, NA
CSCs↓, Casp3↑, cl‑PARP↝, Apoptosis↑, ROS↑, ABC↓, OXPHOS↓, Glycolysis↓, Synergy↑, TumAuto↑, DNAdam↑, Wnt↓, Ferritin↓, Iron↑,
4912- Sal,    Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vitro, Lung, Calu-1 - in-vitro, Lung, H157
CSCs↓, TumAuto↑, ER Stress↑, TumCD↑, ATF4↑, CHOP/DDIT3↑, AKT1↓, mTOR↓,
5124- Sal,    Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance
- in-vitro, BC, NA
CSCs↓, LC3II↑, other↓, lysosome↓, CTSZ↓, CTSB↓, CTSL↓, CTSS↓, autoF↓, TumAuto↓,
6447- SAO,    Autophagy Induction by α-Santalol in Human Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
p‑Akt↓, p‑mTOR↓, TumAuto↑,
9280- SES, SSM,    A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum)
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, Inflam↓, TumMeta↓, angioG↓, ROS↓, TumAuto↓,
2445- SFN,    Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCCA↑, P21↑, p27/CDKN1B↑, NO↑, Akt↓, ATP↓, AMPK↑, TumAuto↑, DNMT1↓, HK2↓, PKM2↓, HDAC3↓, HDAC4↓, HDAC8↓,
1455- SFN,    Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress
- in-vitro, Cerv, HeLa - in-vitro, Nor, 1321N1
*ROS↓, *BioAv↑, LC3II↑, LAMP1?, TumAuto↑, TFEB↑, ROS↑, eff↓,
3298- SIL,    Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells
- in-vitro, BC, MCF7
LC3II↑, Beclin-1/ATG6↑, Bcl-2↓, ROS↑, MMP↓, ATP↓, eff↓, BNIP3?, TumAuto↑, eff↑,
2410- SIL,    Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated BNIP3-dependent nuclear translocation of AIF
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vivo, NA, NA
TumAuto↑, ATP↓, Glycolysis↓, H2O2↑, P53↑, GSH↓, xCT/SLC7A11↓, BNIP3↝, MMP↑, mt-ROS↑, mtDam↑, HK2↓, PFKP↓, PKM2↓, TumCG↓,
2415- SK,    Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways
- in-vivo, Arthritis, NA
Apoptosis?, TumAuto↑, ROS↑, ATP↓, Glycolysis↓, PI3K↓, Akt↓, mTOR↓, *Apoptosis↓, *Inflam↓, *TNF-α↓, *IL6↓, *IL8↓, *IL10↓, *IL17↓, *hepatoP↑, *RenoP↑, PKM2↓, GLUT1↓, HK2↓,
2355- SK,    Pharmacological properties and derivatives of shikonin-A review in recent years
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, TumAuto↑, Necroptosis↑, ROS↑, TrxR1↓, PKM2↓, RIP1↓, RIP3↓, Src↓, FAK↓, PI3K↓, Akt↓, mTOR↓, GRP58↓, MMPs↓, ATF2↓, cl‑PARP↑, Casp3↑, p‑p38↑, p‑JNK↑, p‑ERK↓,
2232- SK,    Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis
- in-vitro, ESCC, EC9706
tumCV↓, TumCMig↓, TumCI↓, TumAuto↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, AMPK↑, mTOR↑, TumVol↓, OS↑, LC3I↑,
2229- SK,    Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways
- in-vitro, Melanoma, A375
Apoptosis↑, TumAuto↑, TumCP↓, TumCCA↑, P21↑, cycD1/CCND1↓, ER Stress↑, p‑eIF2α↑, CHOP/DDIT3↑, cl‑Casp3↑, p38↑, LC3B-II↑, Beclin-1/ATG6↑, ROS↑, eff↓,
5101- SK,    Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis
- vitro+vivo, CRC, SW-620 - vitro+vivo, CRC, HCT116
Apoptosis↑, TumAuto↑, Gal1↑, TumCP↓, ROS↑, eff↑,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,
4891- Sper,    Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms
- Review, Var, NA - Review, AD, NA
TumCCA↑, TumCP↓, TumCG↓, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *mitResp↑, AntiCan↑, TumCD↑, TumAuto↑, *AntiAge↑, LC3B-II↑, ATG5↑, Beclin-1/ATG6↑, mt-ROS↑, H2O2↑, Apoptosis↑, *ROS↑, ChemoSen↑, MMP↓, Cyt‑c↑,

Showing Research Papers: 251 to 300 of 320
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 320

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   ARE↓, 1,   Catalase↓, 4,   Catalase↑, 5,   DJ-1↓, 1,   Fenton↑, 3,   GPx↓, 1,   GPx4↓, 10,   GPx4↑, 1,   GSH↓, 14,   GSH↑, 2,   GSH/GSSG↓, 1,   GSR↑, 1,   GSTs↑, 2,   H2O2↑, 8,   HNE↑, 1,   HO-1↓, 6,   HO-1↑, 3,   Iron↑, 9,   i-Iron↓, 1,   i-Iron↑, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 2,   lipid-P↑, 7,   MDA↓, 2,   MDA↑, 5,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 9,   NRF2↑, 4,   NRF2↝, 1,   Prx↓, 2,   PrxI↓, 1,   PrxII↓, 1,   ROS↓, 14,   ROS↑, 169,   ROS⇅, 2,   ROS↝, 2,   i-ROS↑, 1,   m-ROS↑, 1,   mt-ROS↑, 4,   SOD?, 1,   SOD↓, 3,   SOD↑, 2,   mt-SOD↑, 1,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   TKT↓, 1,   TrxR↓, 2,   TrxR1↓, 3,   xCT/SLC7A11↓, 4,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 6,   FTH1↓, 1,   IronCh↑, 1,   NCOA4↑, 1,   SFXN2↓, 1,   Tf↓, 1,   Tf↑, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 4,   CDC25↓, 8,   compI↓, 4,   compIII↓, 1,   compV↓, 1,   EGF↓, 1,   ETC↓, 3,   Insulin↓, 1,   mitResp↓, 2,   mitResp↑, 1,   Mortalin↓, 1,   mtDam↑, 27,   OCR↓, 6,   OCR↑, 1,   OXPHOS↓, 6,   OXPHOS↑, 5,   OXPHOS↝, 1,   mt-OXPHOS↓, 1,   PDH↓, 2,   PDH↝, 1,   PINK1↑, 5,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AApath↓, 1,   ACC↓, 1,   ACC-α↓, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 4,   ACSL4↑, 1,   ALAT↓, 2,   ALDOA↓, 1,   AMP↓, 1,   AMP↑, 1,   AMPK↑, 26,   p‑AMPK↑, 2,   ATGL/PNPLA2↓, 1,   ATP↓, 26,   ATP↝, 1,   CRM↑, 2,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 2,   FFA/NEFA↓, 1,   GAPDH↓, 1,   GLS↑, 1,   glucose↓, 2,   GlucoseCon↓, 4,   GlucoseCon↑, 1,   GlutMet↑, 1,   Glycolysis↓, 25,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   Histones↝, 1,   HK1↓, 1,   HK2↓, 15,   HK2↑, 1,   HMG-CoA↓, 3,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 12,   lactateProd↑, 1,   LDHA↓, 4,   LDHA↑, 1,   LDL↓, 1,   lipoGen↓, 2,   MCT4↓, 1,   NAD↑, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 3,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFK↓, 1,   PFKP↓, 1,   PKM2↓, 10,   PKM2↑, 1,   PLA2↓, 1,   p‑S6↓, 1,   SCP2↓, 1,   SIRT1↓, 5,   SIRT1↑, 4,   SREBP1/SREBF1↓, 2,   TCA↓, 2,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 4,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 183,   mt-Apoptosis↑, 1,   ASC↓, 1,   BAD↓, 1,   BAD↑, 5,   Bak↑, 1,   BAX↓, 1,   BAX↑, 50,   Bax:Bcl2↑, 15,   Bcl-2↓, 57,   Bcl-2↑, 1,   Bcl-xL↓, 12,   Bcl-xL↑, 2,   BID↑, 2,   cl‑BID↑, 1,   BIM↑, 2,   BNIP3?, 1,   BNIP3↝, 2,   Casp↑, 16,   cl‑Casp↑, 1,   Casp1↓, 2,   proCasp1↓, 1,   Casp12↑, 2,   Casp3↓, 2,   Casp3↑, 62,   cl‑Casp3↑, 29,   proCasp3↓, 1,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp6↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 14,   cl‑Casp8↑, 2,   proCasp8↑, 2,   Casp9↑, 33,   cl‑Casp9↑, 7,   proCasp9↑, 1,   CellShr↑, 1,   cFLIP↓, 3,   Cyt‑c↑, 41,   DR5↑, 9,   Endon↑, 1,   FADD↑, 3,   Fap1↓, 1,   Fas?, 1,   Fas↓, 2,   Fas↑, 13,   FasL↑, 8,   Ferroptosis↓, 1,   Ferroptosis↑, 20,   GRP58↓, 1,   IAP1↓, 4,   ICD↑, 2,   iNOS↓, 5,   iNOS↑, 1,   Mcl-1↓, 4,   MDM2↓, 8,   MLKL↑, 2,   p‑MLKL↓, 1,   MOMP↑, 5,   Necroptosis↑, 4,   necrosis↑, 8,   NOXA↑, 1,   oncosis↑, 2,   P2X7↓, 1,   p38↓, 4,   p38↑, 11,   p‑p38↑, 3,   Paraptosis↑, 2,   PUMA↓, 1,   PUMA↑, 2,   Pyro↑, 2,   RIP3↓, 1,   RIP3↑, 2,   p‑RIP3↑, 2,   survivin↓, 20,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAIL⇅, 1,   TRAILR↑, 2,   TumCD↓, 1,   TumCD↑, 18,   XIAP↓, 7,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 87,   Akt↑, 4,   p‑Akt↓, 21,   p‑Akt↑, 1,   AKT1↓, 3,   AMPKα↑, 3,   BCAP↓, 1,   CaMKII ↓, 1,   Cavin3↓, 1,   CIP2A↓, 2,   cMET↓, 1,   p‑cMET↑, 1,   EGFR↓, 13,   ERK↓, 17,   ERK↑, 3,   ERK↝, 2,   p‑ERK↓, 6,   p‑ERK↑, 3,   FOXD3↑, 1,   GNAI1↓, 1,   HER2/EBBR2↓, 6,   Hippo↓, 1,   IGFR↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB↑, 1,   JAK↓, 2,   JAK1↓, 2,   JAK2↓, 2,   JAK3↓, 1,   JNK↓, 3,   JNK↑, 18,   p‑JNK↑, 2,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 14,   MAPK↑, 11,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 1,   MEK↓, 3,   MEK↑, 1,   MKK4↓, 1,   mTOR↓, 75,   mTOR↑, 7,   mTOR∅, 1,   p‑mTOR↓, 13,   p‑mTOR↑, 1,   mTORC2↓, 2,   p‑p70S6↓, 2,   P70S6K↓, 6,   P70S6K↑, 1,   p‑P70S6K↓, 1,   p‑P70S6K↑, 1,   PDE3B↓, 1,   PDGFR-BB↑, 1,   PDGFRB↓, 1,   PI3K↓, 64,   PI3K↑, 1,   p‑PI3K↓, 3,   PI3k/Akt/mTOR↓, 2,   PIK3CA↑, 1,   p‑PIK3R1↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 3,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 7,   Raf↓, 1,   RAS↓, 5,   Rictor↓, 1,   RIP1↓, 2,   SHP1↑, 1,   Sp1/3/4↓, 7,   Src↓, 1,   STAT↓, 2,   STAT3↓, 19,   STAT3↑, 3,   STAT3↝, 2,   p‑STAT3↓, 1,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 7,   cJun↓, 1,   cJun↑, 2,   cMyc↓, 10,   cMyc↑, 2,   p‑cMyc↑, 1,   COMP↓, 1,   CREBBP↓, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 1,   EZH2↓, 2,   FOXM1↓, 1,   FOXO↓, 1,   FOXO1↓, 1,   FOXO1↑, 3,   FOXO3↓, 2,   FOXO3↑, 3,   FOXO3↝, 1,   FOXO4↑, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HDAC↓, 8,   HDAC∅, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 2,   HES1↓, 1,   HMTs↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-140↑, 1,   miR-155↓, 1,   miR-182-5p↓, 1,   miR-199↓, 1,   miR-200c↑, 1,   miR-21↓, 4,   miR-224↓, 1,   miR-25-5p↓, 1,   miR-29b↓, 1,   miR-340↓, 1,   miR-34a↑, 2,   miR-375↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-486↑, 1,   miR-592↑, 1,   MTA2↓, 1,   Myc↓, 2,   OCT4↓, 4,   other?, 1,   other↓, 5,   other↑, 4,   other↝, 17,   SOX2↓, 1,   SOX4↓, 2,   SUV39H↓, 1,   TFAP2A↓, 1,   TFE3↑, 2,   tumCV?, 1,   tumCV↓, 41,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 19,   CHOP/DDIT3↝, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 1,   eIF2α↑, 6,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 50,   Erlin1↑, 1,   ERStress↑, 1,   GRP78/BiP↓, 3,   GRP78/BiP↑, 9,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 10,   HSP90↑, 1,   HSPs↑, 1,   IRE1↓, 1,   IRE1↑, 2,   p‑IRE1↑, 1,   PDI↑, 2,   PERK↑, 7,   Proteasome↓, 1,   UPR↑, 6,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

APA↑, 1,   ATG13↑, 2,   ATG16L1↑, 1,   ATG3↑, 5,   ATG5↑, 17,   ATG5↝, 1,   ATG7↑, 7,   autoF↓, 2,   autolysosome↑, 1,   AVOs↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 49,   Beclin-1/ATG6↝, 1,   p‑Beclin-1/ATG6↑, 2,   CTSB↓, 2,   CTSD↓, 1,   CTSL↓, 1,   CTSL↑, 1,   CTSS↓, 1,   CTSZ↓, 1,   LAMP1?, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 14,   LC3A↑, 1,   LC3B↑, 5,   LC3B-II↓, 1,   LC3B-II↑, 11,   LC3I↓, 1,   LC3I↑, 2,   LC3II↑, 41,   LC3s↓, 1,   LC3s↑, 3,   LC3s↝, 1,   lysoM↓, 1,   LysoPr↑, 1,   lysosome↓, 3,   MitoP↑, 3,   p62↓, 28,   p62↑, 11,   PARK2↑, 4,   RUBCN↓, 1,   TFEB↑, 1,   TumAuto?, 1,   TumAuto↓, 16,   TumAuto↑, 299,   TumAuto⇅, 2,   TumAuto↝, 3,   mt-TumAuto↑, 2,   ULK1/ATG1↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↝, 1,   DFF45↑, 1,   DNAdam↑, 31,   DNAdam⇅, 1,   DNArepair↓, 1,   DNArepair↑, 1,   ERCC3↑, 1,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 4,   p16↑, 2,   P53↓, 3,   P53↑, 45,   p‑P53↑, 4,   PARP↓, 1,   PARP↑, 10,   p‑PARP↑, 1,   cl‑PARP↑, 34,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 5,   RAD51↓, 1,   Telomerase↓, 4,   TP53↓, 1,   TP53↑, 1,   TRF2↓, 1,   XRCC1↓, 1,   γH2AX↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 5,   CDK1↑, 1,   CDK2↓, 6,   CDK2↑, 2,   CDK4↓, 6,   CDK4↑, 1,   CDK4/6↓, 1,   CDK6↓, 4,   CDK6↑, 1,   CDK7↓, 1,   CDKN1C/p57↓, 1,   p‑CHK1↑, 2,   p‑Chk2↑, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 9,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 18,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 4,   cycE1↓, 1,   E2Fs↓, 2,   Ki-67↓, 11,   MAD↓, 1,   mitA↓, 1,   mitA↑, 1,   P21↓, 2,   P21↑, 21,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 8,   RB1↑, 1,   TumCCA↓, 3,   TumCCA↑, 96,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   4E-BP1↑, 1,   p‑4E-BP1↓, 3,   ALDH↓, 2,   ALDH1A1↓, 1,   BMI1↓, 3,   BMP2↓, 1,   BMP7/OP1↓, 1,   CD133↓, 2,   CD24↓, 1,   cFos↓, 1,   cMYB↓, 1,   CSCs↓, 24,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 2,   EIF4E↓, 1,   Gli1↓, 2,   HH↓, 5,   HMGCR↓, 2,   IGF-1↓, 3,   JAG1↓, 1,   p‑Jun↑, 1,   Ki-67↓, 11,   Let-7↑, 1,   LGR5↓, 1,   mTORC1↓, 9,   Nanog↓, 4,   NICD↓, 1,   NOTCH↓, 6,   NOTCH↑, 1,   NOTCH1↓, 6,   NOTCH1↑, 1,   NOTCH3↓, 1,   Piezo1↑, 1,   PTCH1↓, 1,   Shh↓, 2,   Smo↓, 1,   STAT1↓, 1,   TAZ↓, 1,   TumCG?, 1,   TumCG↓, 60,   TumCG↑, 1,   TumCG⇅, 1,   TumCP?, 1,   TumCP↓, 106,   TumCP↑, 2,   tyrosinase↓, 1,   Wnt↓, 23,   Wnt/(β-catenin)↓, 4,   Wnt/(β-catenin)↑, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AGRN↓, 1,   annexin II↓, 1,   AP-1↓, 2,   AP-1↑, 1,   ASAP2↓, 1,   AXL↓, 1,   Ca+2↓, 2,   Ca+2↑, 19,   CAFs/TAFs↓, 1,   Cal1↑, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 1,   Chl↑, 1,   COL1↓, 2,   COL2A1↓, 1,   COL4A3↓, 1,   COL9A3↓, 1,   E-cadherin↑, 14,   EMT↓, 30,   EMT↑, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 5,   FAK↑, 1,   Fibronectin↓, 1,   GLI2↓, 1,   GP1BB↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 1,   ITGB6↓, 2,   LAMA5↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP15↓, 1,   MMP16↓, 1,   MMP2↓, 27,   MMP3↓, 5,   MMP9↓, 34,   MMP9:TIMP1↓, 1,   MMPs↓, 7,   MTA1↓, 1,   N-cadherin↓, 7,   NCAM↑, 1,   PAK1↓, 3,   PAK1↑, 1,   RECK↑, 1,   Rho↓, 1,   ROCK1↓, 2,   Sharpin↓, 1,   Slug↓, 4,   Smad1↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 9,   STAC2↓, 1,   TET1↑, 2,   TGF-β↓, 6,   TGF-β↑, 2,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 3,   TIMP2↑, 4,   TSC1↑, 1,   TumCA↓, 2,   TumCA↑, 1,   TumCI?, 1,   TumCI↓, 49,   TumCMig↓, 42,   TumMeta↓, 37,   TumMeta↑, 1,   Twist↓, 3,   uPA↓, 6,   uPAR↓, 1,   Vim↓, 14,   Zeb1↓, 3,   ZEB2↓, 1,   α-SMA↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 19,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 50,   angioG↑, 2,   CD31/PECAM-1↓, 2,   ECM/TCF↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 1,   HIF-1↓, 3,   Hif1a↓, 21,   Hif1a↑, 2,   NO↓, 2,   NO↑, 3,   TYMP/ECGF1↓, 1,   VCAM-1↓, 1,   VEGF↓, 30,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 8,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   BBB∅, 1,   CLDN1↓, 1,   CX43/GJA1↓, 1,   EPR↑, 2,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT4↓, 1,   MMP?, 1,   MMP↓, 72,   MMP↑, 1,   MPT↑, 5,   TRPM7↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 6,   CD59↑, 1,   COX2/PTGS2↓, 25,   COX2/PTGS2↑, 1,   CXCL6/GCP-2↓, 1,   CXCR4↓, 3,   DR4↑, 4,   FOXP3↑, 2,   Gal1↑, 1,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 2,   Igs↑, 1,   IL1↓, 4,   IL10↓, 3,   IL17↓, 1,   IL1β↓, 6,   IL1β↑, 1,   IL2↓, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 13,   IL8↓, 3,   Imm↑, 14,   Imm↝, 3,   Inflam↓, 20,   Inflam↝, 1,   IRAK1↓, 1,   LRIG1↑, 1,   pol-M1↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MIP2↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB↓, 51,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 2,   NLRP3↑, 2,   NOD1↓, 1,   p65↓, 1,   PD-1↓, 1,   PD-L1↓, 4,   PGE2↓, 7,   PSA↓, 1,   RAGE↓, 2,   T-Cell↑, 1,   TCF↓, 1,   TCF↝, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 5,   TLR4↑, 1,   TNF-α↓, 11,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,   e-pH↑, 2,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AR↓, 4,   CYP19↓, 1,   ER-α36↓, 1,   Estro↝, 1,   PPARγ↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   ABCG2↓, 2,   BioAv↓, 22,   BioAv↑, 19,   BioAv↝, 5,   BioEnh↑, 2,   CBR1↓, 1,   ChemoSen↓, 4,   ChemoSen↑, 77,   CompStab?, 1,   CompStab↓, 1,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 32,   Dose∅, 7,   eff↓, 46,   eff↑, 57,   eff↝, 5,   eff∅, 1,   GSTZ1↓, 1,   Half-Life↓, 6,   Half-Life↝, 3,   MDR1↓, 7,   P-gp/ABCB1↓, 12,   P-gp/ABCB1↝, 1,   P450↓, 1,   RadioS↑, 27,   selectivity↓, 1,   selectivity↑, 37,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 57,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 4,   AST↓, 2,   BRCA1↓, 1,   BRCA1↝, 1,   CA19-9↓, 1,   CEA↓, 1,   EGFR↓, 13,   EZH2↓, 2,   Ferritin↓, 6,   FOXM1↓, 1,   HER2/EBBR2↓, 6,   hTERT/TERT↓, 4,   IL6↓, 13,   LDH↓, 8,   LDH↑, 2,   p‑LDH↓, 1,   Myc↓, 2,   PD-L1↓, 4,   PSA↓, 1,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 3,   AntiCan↑, 33,   antiD↑, 1,   antiNeop↑, 2,   AntiTum↑, 14,   cachexia↓, 1,   cardioP↑, 4,   CardioT↑, 1,   chemoP↑, 11,   chemoPv↑, 8,   ChemoSideEff↓, 4,   cognitive↑, 1,   fatigue↓, 2,   hepatoP↓, 1,   hepatoP↑, 1,   hepatoP∅, 1,   Mucositis↓, 1,   neuroP↑, 2,   OS↑, 9,   OS∅, 1,   PFS∅, 1,   QoL↑, 4,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 3,   Risk↓, 9,   Sleep↑, 1,   toxicity↓, 15,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 3,   TumVol↓, 21,   TumW↓, 13,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 7,  
Total Targets: 896

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 27,   ARE↑, 1,   Catalase↑, 9,   GPx↑, 7,   GPx1↑, 2,   GPx4↑, 2,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 3,   HO-1?, 1,   HO-1↑, 4,   i-Iron↓, 1,   lipid-P↓, 8,   MDA↓, 5,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 11,   ROS↓, 29,   ROS↑, 1,   SOD↑, 10,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↑, 1,   mtDam↓, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 1,   glucose↓, 2,   glucose↝, 1,   H2S↑, 1,   LDL↓, 3,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 2,   Casp3↓, 4,   Casp9↓, 2,   Cyt‑c↓, 1,   Ferroptosis↓, 1,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↑, 1,   CREB↑, 1,   MAPK↓, 3,   mTOR↓, 1,   mTOR↑, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 1,   PI3K↑, 2,   STAT↓, 1,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   HOTAIR↑, 1,   other↑, 2,   other↝, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNArepair↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 1,   Cartilage↑, 1,   MMP9↓, 1,   PAI-1/SERPINE1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 1,   MUC5AC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 5,   CXCR4↓, 1,   IL10↓, 1,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 8,   IL8↓, 2,   Imm↑, 2,   Imm↝, 1,   Inflam↓, 31,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 10,   NF-kB↑, 1,   NLRP3↓, 3,   NLRP3↑, 2,   PGE2↓, 2,   TNF-α↓, 10,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 4,   GABA↑, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 4,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14,   BioAv↑, 10,   BioAv↝, 5,   CompStab↑, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2D6↓, 1,   Dose⇅, 2,   Dose↝, 10,   eff↑, 1,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 2,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BloodF↑, 1,   BP↓, 1,   BUN↓, 1,   colonLen↑, 1,   creat↓, 1,   CRP↓, 2,   IL6↓, 8,   LDH↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 3,   antiAll↑, 2,   AntiArt↑, 4,   AntiCan↓, 1,   AntiCan↑, 9,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 8,   AntiTum↑, 4,   cardioP↑, 17,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 6,   cough?, 1,   hepatoP↑, 11,   memory↑, 4,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 21,   Obesity↓, 2,   OS↑, 1,   Pain↓, 1,   QoL↑, 1,   RenoP↑, 4,   Risk↓, 1,   SoreThr?, 1,   Stroke↓, 6,   Stroke↝, 1,   toxicity?, 1,   toxicity↓, 11,   toxicity↑, 2,   toxicity↝, 11,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↓, 1,   AntiFungal↑, 2,   AntiP↑, 6,   AntiViral↑, 6,   Bacteria↓, 8,   Diar↓, 1,   GutMicro↑, 4,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 178

Scientific Paper Hit Count for: TumAuto, Tumor autophagy
15 Curcumin
13 Silver-NanoParticles
11 Artemisinin
9 salinomycin
7 Apigenin (mainly Parsley)
7 EGCG (Epigallocatechin Gallate)
7 Gambogic Acid
7 Ivermectin
6 Magnetic Fields
6 Baicalein
6 Kaempferol
5 Celastrol
5 Eugenol
5 Spermidine
5 itraconazole
5 Licochalcone A
5 Luteolin
5 Matrine
5 Melatonin
5 Shikonin
5 Selenite (Sodium)
4 Radiotherapy/Radiation
4 Allicin (mainly Garlic)
4 Berberine
4 Capsaicin
4 Dandelion Root
4 hydroxychloroquine
4 Ginkgetin
4 Hyperoside
4 Juglone
4 Phenethyl isothiocyanate
4 Urolithin
4 Vitamin K2
3 Astragalus
3 Atorvastatin
3 Betulinic acid
3 Cynaropicrin
3 Dichloroacetate
3 diet Short Term Fasting
3 Fisetin
3 Hibiscus sabdariffa
3 Isoliquiritigenin
3 Sulforaphane (mainly Broccoli)
3 Isovitexin
3 Licorice
3 Quercetin
2 2-DeoxyGlucose
2 3-bromopyruvate
2 Photodynamic Therapy
2 Metformin
2 Ashwagandha(Withaferin A)
2 Boron
2 Centella asiatica / Gotu kola → asiaticoside
2 Chrysin
2 Cranberry
2 Resveratrol
2 diet Methionine-Restricted Diet
2 Chemotherapy
2 Emodin
2 Formononetin
2 Paclitaxel/Taxol
2 Cisplatin
2 Gossypol/AT-101
2 Graviola
2 HydroxyCitric Acid
2 Honokiol
2 isoquercitrin
2 Methyl Jasmonate
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Phenylbutyrate
2 Propolis -bee glue
2 Phycocyanin
2 Psoralidin
2 Silymarin (Milk Thistle) silibinin
2 Ursolic acid
1 cetuximab
1 5-Aminolevulinic acid
1 entinostat
1 wortmannin
1 Allyl isothiocyanate
1 Alpha-Lipoic-Acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Bufalin/Huachansu
1 Benzyl isothiocyanate
1 borneol
1 Beetroot
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Celecoxib
1 chaetocin
1 chitosan
1 Citric Acid
1 Coenzyme Q10
1 Copper and Cu NanoParticles
1 Cucurbitacin
1 CUSP9
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Ellagic acid
1 Bortezomib
1 Estrogen
1 Beta-Caryophyllene
1 5-fluorouracil
1 Evodiamine
1 Ferulic acid
1 Gallic acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Hydrogen Gas
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Gemcitabine (Gemzar)
1 Helleborus niger extracts – Christmas Rose
1 Isobavachalcone
1 isoorientin
1 Isothiocyanates
1 Vitexin
1 Magnolol
1 mebendazole
1 immunotherapy
1 Magnetic Field Rotating
1 Magnesium
1 Morin
1 doxorubicin
1 Mushroom Chaga, Inonotus obliquus
1 Myricetin
1 Bicarbonate(Sodium)
1 Naringin
1 Patchouli Oil (Pogostemon cablin)
1 Propyl gallate
1 Piperine
1 Plumbagin
1 Parthenolide
1 Pterostilbene
1 α-Santalol/Sandalwood oil
1 Sesamin
1 Spirulina(Arthrospira/Limnospira)
1 VitK3,menadione
1 Vitamin C (Ascorbic Acid)
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:321  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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