VEGF Cancer Research Results

VEGF, Vascular endothelial growth factor: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
A signal protein produced by many cells that stimulates the formation of blood vessels. Vascular endothelial growth factor (VEGF) is a signal protein that plays a crucial role in angiogenesis, the process by which new blood vessels form from existing ones. This process is vital for normal physiological functions, such as wound healing and the menstrual cycle, but it is also a key factor in the growth and spread of tumors in cancer.
Because of its significant role in tumor growth and progression, VEGF has become a target for cancer therapies. Anti-VEGF therapies, such as monoclonal antibodies (e.g., bevacizumab) and small molecule inhibitors, aim to inhibit the action of VEGF, thereby reducing blood supply to tumors and limiting their growth. These therapies have been used in various types of cancer, including colorectal, lung, and breast cancer.
Scientific Papers found: Click to Expand⟱
4243- Gins,    Effects of Ginseng on Neurological Disorders
- Review, Stroke, NA - Review, AD, NA - Review, Park, NA
*BDNF↑, *TrkB↑, *neuroP↑, *VEGF↑, *p‑tau↓, *memory↑,
4505- GLA,    Gamma linolenic acid suppresses hypoxia-induced proliferation and invasion of non-small cell lung cancer cells by inhibition of HIF1α
- in-vitro, NSCLC, Calu-1
TumCP↓, PCNA↓, Ki-67↓, MCM2↓, Bcl-2↓, BAX↑, cl‑Casp3↑, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
7311- Gos,    Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials
- Review, CLL, NA
Dose↝, toxicity↓, PFS↓, OS↑, Synergy↑, BioAv↑, Bcl-2↓, ROS↑, MOMP↑, Dose↑, Casp3↑, Casp9↑, MMP↑, VEGF↓, APE1/APEX1↓, ChemoSen↑, RadioS↑, toxicity↑, AST↑, ALAT↑,
850- Gra,    Selective cytotoxic and anti-metastatic activity in DU-145 prostate cancer cells induced by Annona muricata L. bark extract and phytochemical, annonacin
- in-vitro, PC, PC3 - in-vitro, Pca, DU145
ROS∅, MMP∅, Casp3↑, Casp7↑, VEGF↓,
1241- GSE,  PACs,    Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietin signaling
- in-vitro, Nor, NA
*VEGF↓, *MMP2↓, *MMP9↓, *p‑VEGFR2/KDR/Flk1↓,
3764- H2,    Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model
- in-vivo, AD, NA
*memory↑, *Aβ↓, *p‑tau↓, *BAX↓, *ROS↓, *NO↓, *Ca+2↓, *MDA↓, *Catalase↓, *GPx↓, *TNF-α↓, *Bcl-2↑, *VEGF↑, *Inflam↓, *cognitive↑,
3768- H2,    Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial
- Trial, AD, NA
*ROS↓, *NO↓, *BACE/β-secretase↓, *BDNF↑, *VEGF↑, *p‑tau↓, *MCP1/CCL2↓, *IL6↓, *cognitive↑, *toxicity∅,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,
7929- H2,    Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma
- in-vivo, Asthma, NA
*IL4↓, *IL5↓, *IL13↓, *TNF-α↓, *AirwayM↓, *MUC5AC↓, *COL3A1↓, *VEGF↓, *NF-kB↓, *Inflam↓, *antiAll↑,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, Synergy↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2/PTGS2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27/CDKN1B↑, P53↑, VEGF↓, MAPK↓,
1649- HCAs,    Anticancer Properties of Hydroxycinnamic Acids -A Review
- Review, Var, NA
*antiOx↑, MMP2↓, MMP9↓, VEGF↓, TGF-β↓, Bax:Bcl2↑, TumCCA↑, COX2/PTGS2↓, NF-kB↓,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2871- HNK,    Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *VEGF↓, *NRF2↑, *SOD2↑, *HO-1↑, *Inflam↓, *Pain↓, *NO↓, toxicity↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,
2897- HNK,    Honokiol Inhibits Proliferation, Invasion and Induces Apoptosis Through Targeting Lyn Kinase in Human Lung Adenocarcinoma Cells
- in-vitro, Lung, PC9 - in-vitro, Lung, A549
TumCP↓, Apoptosis↑, EGFR↓, PI3K↓, Akt↓, STAT3↓, TumCI↓, TNF-α↑, NF-kB↓, VEGF↓, MMP9↓, COX2/PTGS2↓,
7469- Hops,    CHEMOPREVENTIVE PROPERTIES OF SPENT HOPS (HUMULUS LUPULUS L.) EXTRACT AGAINST ANGIOGENESIS, INVASION AND MIGRATION OF COLORECTAL CANCER CELLS
- in-vitro, CRC, SW48 - in-vitro, CRC, HT29
angioG↓, TumCI↓, TumCMig↓, MMP2↓, MMP9↓, VEGF↓, Hif1a↓, chemoPv↑,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7635- Ins,    The Role of Inositols in Endocrine and Neuroendocrine Tumors
- Review, Thyroid, NA
*Dose↝, VEGF↓, Imm↑, NK cell↑, Synergy↑, PI3K↓, Akt↓, EMT↓, MAPK↓, Wnt↓, NF-kB↓, IRes↓, *ROS↓, TumVol↓, *TSHR↓,
7676- iod,    Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)
- in-vivo, BC, NA
TumCP↓, Apoptosis↑, Dose↝, other↑, BloodF↓, VEGF↓, UroPA↓, PPARα↓, DR4↑, Casp3↑, PPARγ↑, antiNeop↑, Risk↓, 6IL↑,
7681- iod,  mCHEMO,    Molecular Iodine Improves the Efficacy and Reduces the Side Effects of Metronomic Cyclophosphamide Treatment against Mammary Cancer Progression
- in-vivo, BC, NA
tumCV↓, Imm↑, chemoP↑, Weight↑, TumCG↓, VEGF↓, survivin↓, ChemoSen↑,
7687- iod,  ESWT,    Shock Wave Application Increases the Antineoplastic Effect of Molecular Iodine Supplement in Breast Cancer Xenografts
- in-vivo, BC, MDA-MB-231
antiNeop↑, CSCsMark↓, CD44↓, SOX2↓, HIF-1↓, VEGF↓, Dose↝, Dose↝, EPR↝, PPARγ↑,
7715- IP6,    Inositol hexaphosphate (IP6) inhibits cellular proliferation in melanoma
- in-vitro, Melanoma, HTB68
TumCP↓, VEGF↓, Apoptosis↑,
7717- IP6,    In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor
- in-vivo, Pca, DU145
TumCG↓, IGFBP3↑, VEGF↓, TumCP↓, angioG↓,
7691- IP6,    Inositol Hexaphosphate Suppresses Growth and Induces Apoptosis in Prostate Carcinoma Cells in Culture and Nude Mouse Xenograft: PI3K-Akt Pathway as Potential Target
- vitro+vivo, Pca, PC3 - in-vitro, Pca, C4-2B
TumCP↓, Apoptosis↑, Casp3↑, cl‑PARP↑, Akt↓, PI3K↓, p‑GSK‐3β↓, cycD1/CCND1↓, TumVol↓, TumW↓, PCNA↓, angioG↓, CD31/PECAM-1↓, ILK↓, VEGF↓, eNOS↓, Hif1a↓,
7750- ISL,    Isoliquiritigenin in Breast Cancer: A Systematic Review of Its Preventive and Anti-metastatic Mechanisms
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumAuto↑, mTOR↓, AApath↓, EMT↓, BRCA1↝, PI3K↓, Akt↓, angioG↓, VEGF↓, Hif1a↓, COX2/PTGS2↓, NF-kB↓,
7749- ISL,    Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1
- in-vitro, GBM, U87MG
angioG↓, COX2/PTGS2↓, mPGES-1↓, CYP4A/CYP4A11/CYP4A22↓, FGF21↓, TGF-β↓, VEGF↓, miR-194↑, NEAT1↓,
7756- ISL,    Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, MDA-MB-231
AntiCan↑, VEGF↓, TumCI↓, TumCMig↓, Hif1a↓, TumCG↓, angioG↓, VEGFR2/KDR/Flk1↓, Apoptosis↑, toxicity↓, TumCCA↑, Inflam↓, ROS↑,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7733- isoFl,    Soy-derived isoflavones as chemo-preventive agents targeting multiple signalling pathways for cancer prevention and therapy
- Review, Var, NA
chemoPv↑, HOTAIR↓, VEGF↓, CXCL12↓, CXCR4↓, ER-α36↝, Shh↓, miR-155↝, miR-34a↝, miR-10a-5p↝, CSCs↓, EMT↓,
7859- isoO,    Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells
- in-vitro, PC, PANC1
tumCV↓, Apoptosis↑, EMT↓, MMPs↓, VEGF↓, AMPK↑, TumCP↓, Dose↝, TumCMig↓, TumCI↓,
2179- itraC,    Repurposing itraconazole for the treatment of cancer
- Review, Var, NA
HH↓, angioG↓, TumCCA↑, MDR1↓, P-gp/ABCB1↓, mTOR↓, VEGF↓, Smo↓, Gli1↓, OS↑, PSA↓,
8007- JG,    Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesis
- in-vitro, GBM, U251
Pin1↓, AntiCan↑, TumCP↓, Apoptosis↑, Casp3↑, TumCMig↓, angioG↓, VEGF↓, CD31/PECAM-1↓, TGF-β1↓,
974- JG,    Juglone down-regulates the Akt-HIF-1α and VEGF signaling pathways and inhibits angiogenesis in MIA Paca-2 pancreatic cancer in vitro
- in-vitro, PC, MIA PaCa-2
Hif1a↓, VEGF↓, p‑Akt↓, TumCP↓, TumCI↓,
5120- JG,    Juglone can inhibit angiogenesis and metastasis in pancreatic cancer cells by targeting Wnt/β-catenin signaling
- in-vitro, PC, NA
angioG↓, Wnt↓, VEGF↓,
5115- JG,    Natural Products to Fight Cancer: A Focus on Juglans regia
- Review, Var, NA
Casp3↑, Casp9↑, MMP↓, AR↓, PSA↓, E-cadherin↑, N-cadherin↓, Vim↓, Akt↓, GSK‐3β↓, EMT↑, TumCI↓, MMP9↓, VEGF↓, MMP2↓, TumCCA↑, ROS↑, Apoptosis↑, GSH↓, Catalase↓, SOD↓, GPx↓, DNAdam↑, γH2AX↑, Synergy↑, BAX↑, Fas↑, Pin1↓,
8085- KAE,    Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, PI3K↓, Akt↓, STAT3↓, AP-1↓, NRF2↓, BioAv↑, Inflam↓, NF-kB↓, TNF-α↓, VEGF↓, BAX↑, Casp↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, NRF2↓, ROS↑, DR5↑, ERK↑, CHOP/DDIT3↑, DR4↑, JNK↑, Ki-67↓, ChemoSen↑,
8097- KAE,    The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells
- in-vitro, CRC, LS174T
ChemoSen↑, tumCV↓, Apoptosis↑, TumCCA↑, ROS↓, Casp3↑, Casp9↑, cl‑PARP↑, p‑STAT3↓, Akt↓, FOXO3↓, NF-kB↓, VEGF↓, TS↓, TK1↓,
8071- KAE,    Cellular reprogramming and signaling control by kaempferol in colorectal cancer
- Review, CRC, NA
*toxicity↓, Risk↓, MMPs↓, VEGF↓, VEGFR1↓, Wnt↓, β-catenin/ZEB1↑, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, *BioAv↓, TumCCA↑, Apoptosis↑, Hif1a↓, ROS↑, TumCMig↓, TumMeta↓, PKM2↓, Glycolysis↓, DNAdam↑, HO-1↑, Ferroptosis↑, eff↑, Dose↝, BioAv↑,
8061- KAE,    Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway
- in-vitro, Ovarian, A2780S - in-vitro, Ovarian, OVCAR-3
TumCP↓, Apoptosis↑, Casp3↑, Casp7↑, Risk↓, VEGF↓, TumCP↓, Dose↝, P53↑,
8076- KAE,    Kaempferol suppresses prostate cancer metastasis and tumor angiogenesis via disrupting the LIMK1/Cofilin pathway
- in-vivo, Pca, NA
AntiTum↑, TumCP↓, TumCCA↑, VEGF↓, CDK4↓, CDK6↓, LIMK1↓, Cofilin↓, angioG↓,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8151- lamb,    Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid
- in-vitro, BC, MCF7 - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCCA↑, cl‑PARP↑, p‑STAT3↓, NF-kB↓, XIAP?, survivin↓, Bcl-2↓, Bcl-xL↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ac‑p65↑, Obesity↓, miR-134↑,

Showing Research Papers: 251 to 300 of 466
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 466

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 8,   antiOx⇅, 1,   ARE↓, 1,   Catalase↓, 8,   Catalase↑, 4,   Copper↑, 1,   Fenton↑, 1,   GPx↓, 3,   GPx↑, 4,   GPx4↓, 4,   GSH↓, 26,   GSH↑, 5,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 9,   HO-1↑, 15,   HO-2↓, 1,   Iron↑, 1,   Iron∅, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 9,   MDA↓, 5,   MDA↑, 4,   MPO↓, 2,   NADH↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↓, 2,   NQO1↑, 3,   NRF2↓, 24,   NRF2↑, 24,   NRF2↝, 1,   p‑NRF2↓, 1,   OSI↑, 1,   Prx4↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROMO1↑, 1,   ROS?, 1,   ROS↓, 16,   ROS↑, 175,   ROS⇅, 12,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 11,   SOD↑, 6,   SOD2↓, 4,   TAC↓, 3,   Thiols↓, 1,   TOS↑, 1,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 5,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC2↓, 8,   CDC25↓, 8,   EGF↓, 6,   ETC↓, 2,   HSP60/HSPD1↓, 2,   mitResp↓, 4,   MKK7↓, 2,   Mortalin↓, 1,   mtDam↑, 10,   OCR↓, 3,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 3,   PINK1↑, 1,   SIRT3↓, 2,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 6,   AApath↓, 1,   ACC↑, 2,   ALAT↓, 5,   ALAT↑, 1,   ALAT↝, 1,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 20,   p‑AMPK↑, 1,   p‑AMT/GCST/T-protein↑, 1,   ARG↓, 1,   ATP↓, 14,   ATP↑, 1,   ATP↝, 1,   i-ATP↓, 1,   mt-ATP↓, 1,   CAIX/CA9↓, 2,   CAIX/CA9↑, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   ECAR↓, 2,   ECAR↝, 1,   ENO1↓, 1,   FABP5/E-FABP↓, 1,   FASN↓, 7,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucose↓, 1,   GlucoseCon↓, 10,   GlutMet↓, 1,   Glycolysis↓, 31,   GSK‐3β↓, 11,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 7,   HK2↓, 12,   IDO1↓, 1,   lactateProd↓, 11,   lactateProd↑, 1,   e-lactateProd↓, 1,   LDHA↓, 9,   LDL↓, 1,   MCT4↓, 1,   NADPH↓, 1,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 11,   PDK3↑, 1,   PFK↓, 1,   PKM2↓, 11,   PKM2↑, 1,   p‑S6↓, 2,   SCD1↓, 1,   SIRT1↓, 6,   SIRT1↑, 8,   SIRT2↓, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 7,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 152,   Apoptosis↝, 1,   mt-Apoptosis↑, 2,   ASC↓, 1,   ASC↑, 1,   ASK1↑, 2,   BAD↓, 3,   BAD↑, 9,   Bak↑, 11,   BAX↓, 2,   BAX↑, 86,   BAX⇅, 1,   BAX↝, 1,   BAX∅, 1,   Bax:Bcl2↑, 26,   Bcl-2↓, 116,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↓, 41,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 4,   BIM↓, 1,   BIM↑, 4,   BNIP3↑, 3,   BNIP3↝, 1,   Casp↓, 1,   Casp↑, 33,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp10↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 118,   Casp3↝, 1,   cl‑Casp3↑, 17,   proCasp3↑, 1,   Casp6↑, 1,   Casp7?, 1,   Casp7↑, 16,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 29,   cl‑Casp8↑, 6,   proCasp8↑, 1,   Casp9?, 1,   Casp9↑, 69,   cl‑Casp9↑, 9,   proCasp9↓, 1,   cFLIP↓, 5,   Cyt‑c↑, 67,   Cyt‑c↝, 3,   mt-Cyt‑c↓, 1,   Diablo↑, 10,   DIDO1/DIO-1↑, 1,   DR5↑, 21,   Endon↑, 1,   FADD↑, 3,   Fas↑, 22,   FasL↑, 6,   Ferroptosis↑, 7,   GSDME↑, 1,   HEY1↓, 2,   IAP1↓, 14,   IAP1↑, 1,   IAP2/BIRC3↓, 7,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICAD↑, 1,   iNOS↓, 21,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 29,   MDM2↓, 9,   MDM2↑, 1,   p‑MDM2↓, 2,   MOMP↑, 2,   Necroptosis↑, 4,   necrosis↑, 3,   NOXA↑, 4,   oncosis↑, 1,   p38↓, 10,   p38↑, 16,   p‑p38↓, 3,   p‑p38↑, 3,   PUMA↑, 5,   Pyro↑, 3,   RIP1↑, 2,   RIP3↑, 2,   survivin↓, 68,   TNFR 1↑, 1,   TRAIL↑, 4,   TRAIL⇅, 1,   TRAILR↑, 4,   TumCD?, 1,   TumCD↑, 6,   TUNEL↑, 1,   XIAP?, 1,   XIAP↓, 35,   XIAP↑, 1,   YAP/TEAD↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 135,   Akt↑, 4,   Akt↝, 1,   Akt∅, 1,   p‑Akt↓, 36,   BRAF↓, 1,   Brk/PTK6↓, 1,   CK2↓, 5,   cMET↓, 3,   p‑cMET↑, 2,   cSrc↓, 3,   DYRK1B↓, 1,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   ERK↓, 52,   ERK↑, 7,   ERK↝, 1,   ERK∅, 1,   p‑ERK↓, 16,   p‑ERK↑, 2,   ERK5↓, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 2,   HER2/EBBR2↓, 9,   HGF/c-Met↓, 1,   Hippo↝, 1,   IGF-1R↓, 6,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 14,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 2,   p‑IκB↓, 1,   JAK↓, 3,   JAK1↓, 4,   p‑JAK1↓, 1,   JAK2↓, 17,   p‑JAK2↓, 3,   JNK↓, 6,   JNK↑, 20,   JNK↝, 1,   p‑JNK↓, 2,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 29,   MAPK↑, 12,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 10,   MKK4↓, 2,   mTOR↓, 81,   mTOR↝, 1,   p‑mTOR↓, 9,   mTORC2↓, 1,   p‑p70S6↓, 2,   P70S6K↓, 5,   p‑P70S6K↓, 2,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 106,   PI3K↝, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 4,   PI3k/Akt/mTOR↓, 1,   p‑PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 11,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 30,   PTEN↝, 1,   p‑PTEN↓, 1,   PTPN6↑, 1,   Raf↓, 7,   e-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   p‑S6K↓, 2,   SHP1↑, 4,   Sp1/3/4↓, 17,   Src↓, 4,   p‑Src↓, 1,   c-Src↓, 1,   STAT↓, 3,   STAT3↓, 86,   p‑STAT3↓, 20,   p‑STAT3↑, 3,   STAT5↓, 4,   STAT6↓, 3,   p‑STAT6↓, 1,   STK11/LKB1↑, 1,   THEM4/CTMP↑, 1,   TK1↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 2,   ATF4↓, 1,   ATF4↑, 5,   ATF4↝, 1,   CBP↓, 1,   cJun↓, 5,   cJun↑, 1,   cMyc↓, 46,   p‑cMyc↑, 1,   DNMT1↓, 7,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 8,   EZH2↓, 2,   FOXM1↓, 6,   FOXO↑, 2,   FOXO1↓, 2,   FOXO3↓, 5,   FOXO3↑, 5,   FOXO3↝, 1,   FOXO4↓, 2,   H3↓, 1,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 3,   H4↓, 1,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 27,   HDAC1↓, 5,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC8↓, 2,   HES1↓, 2,   HOTAIR↓, 1,   KISS1↑, 1,   miR-10a-5p↝, 1,   miR-133a-3p↑, 1,   miR-134↑, 1,   miR-155↝, 1,   miR-194↑, 1,   miR-200b↑, 2,   miR-200c↑, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-21↓, 5,   miR-21↑, 1,   miR-21↝, 1,   miR-210↓, 1,   miR-210↑, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-30a-5p↑, 1,   miR-34a↑, 3,   miR-34a↝, 1,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-548ah-5p↑, 1,   Myc↓, 9,   MYCN↓, 1,   n-MYC↓, 1,   NDRG1↑, 1,   NEAT1↓, 1,   OCT4↓, 7,   other?, 1,   other↓, 1,   other↑, 3,   other↝, 6,   other∅, 1,   PAX2↓, 1,   PCAF↓, 1,   PhotoS↑, 1,   Prot↓, 1,   SOX2↓, 7,   SOX4↓, 1,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   SUV39H↓, 2,   TFAP2A↓, 1,   tumCV↓, 29,   tumCV∅, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 24,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↓, 2,   eIF2α↑, 2,   p‑eIF2α↑, 2,   ER Stress↓, 2,   ER Stress↑, 29,   GRP78/BiP↓, 3,   GRP78/BiP↑, 9,   HSP27↓, 3,   HSP27↑, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 8,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 11,   HSPs↓, 2,   HTRA↓, 2,   IRE1↑, 2,   PERK↑, 3,   p‑PERK↑, 1,   UPR↑, 7,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 5,   ATG5↝, 1,   ATG7↑, 2,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 14,   Beclin-1/ATG6↝, 1,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3B-II↑, 3,   LC3II↓, 2,   LC3II↑, 12,   LC3s↑, 1,   p62↓, 9,   p62↑, 3,   PARK2↑, 1,   RUBCN↓, 1,   TumAuto↓, 1,   TumAuto↑, 28,   TumAuto⇅, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1,   ATM?, 1,   ATM↑, 1,   p‑ATM↑, 2,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   BRCA2↓, 1,   BRCA2↑, 1,   DFF45↓, 2,   DFF45↑, 1,   DNAdam↓, 2,   DNAdam↑, 45,   DNArepair↓, 3,   DNArepair↑, 2,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 14,   p16↑, 5,   P53?, 1,   P53↓, 4,   P53↑, 74,   P53↝, 1,   p‑P53↓, 1,   p‑P53↑, 4,   PARP↓, 3,   PARP↑, 18,   PARP↝, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 57,   PARP1↑, 3,   cl‑PARP1↑, 1,   PCNA↓, 28,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 15,   TOP1↓, 9,   TOP2↓, 6,   TOP2↑, 2,   TP53↓, 1,   TP53↑, 3,   UHRF1↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 7,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 37,   CDK2↑, 1,   CDK4↓, 46,   CDK4↑, 1,   CDK4/6↓, 2,   CDK6↓, 21,   CDK6↑, 1,   CDK8↓, 2,   CDKN1C/p57↑, 1,   CHK1↓, 3,   CHK1↑, 1,   p‑CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 1,   p‑Chk2↑, 2,   Cyc↓, 3,   Cyc↝, 1,   cycA1/CCNA1↓, 8,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 20,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 82,   cycD1/CCND1↑, 1,   cycD1/CCND1↝, 1,   CycD3↓, 2,   cycE/CCNE↓, 15,   cycE/CCNE↑, 2,   cycE1↓, 2,   cycF↓, 1,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   GADD45A↑, 1,   Ki-67↓, 24,   mitA↑, 2,   P21↓, 4,   P21↑, 55,   P21↝, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 27,   pRB↑, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 6,   TubPol↓, 1,   TumCCA↓, 6,   TumCCA↑, 151,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2,   p‑4E-BP1↓, 1,   ALDH↓, 4,   BMP2↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 3,   CD133↓, 5,   CD133↑, 1,   CD24↓, 1,   CD34↓, 2,   cFos↓, 3,   cFos↑, 1,   cMYB↓, 2,   CSCs↓, 39,   CSCsMark↓, 1,   Diff↓, 1,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 4,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 10,   HH↓, 7,   IGF-1?, 1,   IGF-1↓, 11,   IGF-2↓, 1,   IGFBP3↑, 5,   Jun↓, 1,   Ki-67↓, 24,   Let-7↑, 5,   MCM2↓, 1,   mTORC1↓, 2,   p‑mTORC1↓, 1,   Nanog↓, 6,   Nestin↓, 3,   NICD↓, 1,   NOTCH↓, 17,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH3↓, 3,   p300↓, 2,   PTCH1↓, 3,   PTCH2↓, 1,   SCF↓, 2,   Shh↓, 11,   Smo↓, 6,   STAT1↓, 1,   Sufu↓, 1,   TAZ↓, 1,   TumCG↓, 79,   TumCG↑, 2,   TumCP?, 1,   TumCP↓, 115,   TumCP↑, 1,   tyrosinase↓, 2,   Wnt↓, 38,   Wnt↑, 2,   Wnt/(β-catenin)↓, 9,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   ANGPT2↓, 1,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 14,   AP-1↝, 1,   ARG1/2↑, 1,   ATPase↓, 1,   AXL↓, 3,   BACH1↓, 1,   CA↓, 3,   Ca+2↓, 1,   Ca+2↑, 28,   Ca+2↝, 3,   CAFs/TAFs↓, 2,   cal2↓, 1,   cal2↑, 1,   Cav1↓, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 2,   Cdc42↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 10,   E-cadherin↑, 45,   EM↑, 1,   EMT?, 1,   EMT↓, 72,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 3,   F-actin↓, 3,   FAK↓, 22,   p‑FAK↓, 4,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 3,   GIT1↓, 1,   GLI2↓, 4,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB1↑, 1,   ITGB4↓, 1,   LAMs↓, 3,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 2,   MET↓, 2,   p‑MET↓, 1,   MMP-10↓, 3,   MMP1↓, 8,   MMP13↓, 4,   MMP14↓, 1,   MMP16↓, 1,   MMP2↓, 115,   MMP2↝, 1,   MMP3↓, 11,   MMP7↓, 13,   MMP9↓, 146,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 42,   MMPs↝, 1,   MRGPRF↓, 1,   MTA1↓, 1,   MUC4↓, 2,   N-cadherin↓, 28,   NCAM↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 11,   Rac1↓, 3,   RECK↑, 2,   Rho↓, 5,   Rho↑, 1,   ROCK1↓, 5,   ROCK1↑, 2,   Slug↓, 10,   Smad1↓, 1,   Smad1↑, 1,   SMAD2↓, 2,   p‑SMAD2↓, 1,   SMAD3↓, 3,   p‑SMAD3↓, 1,   Snail?, 1,   Snail↓, 24,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 24,   TGF-β↑, 2,   TGF-β1↓, 3,   TIMP1↓, 2,   TIMP1↑, 12,   TIMP2↓, 3,   TIMP2↑, 14,   TIMP3↑, 1,   TSC1↑, 1,   TSP-1↑, 5,   TumCA↓, 2,   TumCI↓, 68,   TumCMig↓, 73,   TumCMig↑, 1,   TumMeta?, 1,   TumMeta↓, 72,   TumMeta↑, 5,   Twist↓, 26,   TXNIP↑, 1,   Tyro3↓, 1,   uPA↓, 29,   uPAR↓, 4,   UroPA↓, 1,   Vim?, 1,   Vim↓, 34,   Vim↑, 1,   Zeb1↓, 12,   Zeb1↑, 1,   ZEB2↓, 3,   α-SMA↓, 4,   α-tubulin↓, 2,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 47,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 169,   angioG↑, 5,   angioS↑, 1,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 14,   EGR1↑, 1,   Endoglin↓, 1,   Endoglin↑, 1,   eNOS↓, 4,   HIF-1↓, 11,   Hif1a↓, 141,   LOX1↓, 3,   NO↓, 8,   NO↑, 2,   NO↝, 1,   VCAM-1↓, 4,   VEGF↓, 412,   VEGF↑, 5,   VEGF↝, 2,   VEGFR1↓, 7,   VEGFR2/KDR/Flk1↓, 29,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 4,   CLDN1↓, 3,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN2↑, 1,   CTR1↑, 2,   CX43/GJA1↓, 1,   EPR↑, 4,   EPR↝, 1,   GLUT1↓, 20,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   MMP↓, 67,   MMP↑, 5,   MMP∅, 1,   MPT↑, 4,   NHE1↓, 2,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 2,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD4+↑, 2,   CD44↓, 14,   CD8+↑, 2,   COX1↓, 3,   COX2/PTGS2↓, 96,   COX2/PTGS2↑, 3,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 4,   CXCL16↓, 1,   CXCR2↓, 1,   CXCR4↓, 20,   CXCR4↑, 1,   DR4↑, 6,   FOXP3↓, 2,   GM-CSF↓, 2,   HLA-I/II↑, 1,   HMGB1↓, 2,   ICAM-1↓, 12,   IFN-γ↓, 3,   IFN-γ↑, 3,   Igs↑, 1,   IL1↓, 10,   IL10↓, 8,   IL10↑, 3,   IL12↓, 4,   IL12↑, 1,   IL1α↓, 2,   IL1β↓, 13,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 7,   IL4↓, 2,   IL4↑, 1,   IL6↓, 52,   IL6↑, 1,   IL6↝, 1,   IL8↓, 16,   Imm↑, 10,   Imm↝, 3,   INF-γ↑, 1,   Inflam↓, 26,   LIF↑, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 6,   MCT1↓, 1,   MDSCs↓, 2,   MIP2↓, 2,   mPGES-1↓, 3,   MyD88↓, 1,   MyD88↑, 1,   NF-kB↓, 157,   NF-kB↑, 1,   NF-kB↝, 2,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 9,   NLRP3↓, 4,   NLRP3↑, 2,   p50↓, 1,   p65↓, 10,   p65↑, 1,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 3,   PD-L1↓, 11,   PGE2↓, 16,   PSA↓, 9,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 8,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 39,   TNF-α↑, 4,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRAF1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↓, 1,   AChE↑, 1,   SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↑, 1,   AhR↓, 1,   AR↓, 18,   AR↝, 1,   CYP19↓, 2,   ER-α36↓, 2,   ER-α36↝, 1,   ER(estro)↓, 2,   Estro↝, 1,   FGF21↓, 2,   GR↑, 1,   PPARα↓, 3,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 9,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   BioAv↓, 42,   BioAv↑, 48,   BioAv↝, 6,   BioEnh↑, 5,   ChemoSen?, 1,   ChemoSen↓, 1,   ChemoSen↑, 128,   ChemoSen⇅, 1,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP1B1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 4,   Dose↓, 1,   Dose↑, 9,   Dose↝, 33,   Dose∅, 7,   eff↓, 16,   eff↑, 54,   eff↝, 15,   eff∅, 1,   Half-Life↓, 13,   Half-Life↑, 3,   Half-Life↝, 8,   Half-Life∅, 2,   MDR1↓, 10,   MRP1/ABCC1↓, 6,   P-gp/ABCB1↓, 15,   P450↓, 4,   RadioS?, 1,   RadioS↑, 46,   selectivity↑, 50,   Synergy↑, 90,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 3,   ALAT↓, 5,   ALAT↑, 1,   ALAT↝, 1,   ALP↓, 4,   ALP↝, 1,   AR↓, 18,   AR↝, 1,   ascitic↓, 3,   AST↓, 4,   AST↑, 1,   AST↝, 1,   BloodF↓, 1,   BloodF↑, 1,   BRAF↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   BRCA1↝, 1,   CEA↓, 1,   CRP↓, 3,   E6↓, 3,   E7↓, 3,   EGFR↓, 45,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 2,   EZH2↓, 2,   Ferritin↓, 1,   FOXM1↓, 6,   HER2/EBBR2↓, 9,   hTERT/TERT↓, 14,   IL6↓, 52,   IL6↑, 1,   IL6↝, 1,   IRes↓, 1,   LDH↓, 2,   LDH↑, 2,   Maspin↑, 1,   Myc↓, 9,   NSE↓, 1,   PD-L1↓, 11,   PSA↓, 9,   PSA↝, 1,   PSA∅, 1,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 40,   AntiCan∅, 1,   antiNeop↑, 7,   AntiTum↑, 14,   cachexia↓, 2,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 23,   chemoPv↑, 19,   ChemoSideEff↓, 7,   fatigue↓, 2,   hepatoP↑, 5,   Mucositis↓, 1,   neuroP↑, 7,   NP/CIPN↓, 1,   Obesity↓, 1,   ORR↑, 1,   OS↑, 19,   Pain↓, 1,   PFS↓, 1,   PFS↑, 1,   Pin1↓, 2,   QoL↑, 4,   radioP↑, 9,   Remission↑, 1,   RenoP↑, 6,   Risk↓, 12,   Risk↑, 1,   Sleep↑, 1,   toxicity↓, 15,   toxicity↑, 3,   toxicity↝, 4,   toxicity∅, 1,   TumVol↓, 24,   TumW↓, 11,   Weight↓, 1,   Weight↑, 2,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 1080

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↓, 1,   antiOx↑, 64,   Catalase↓, 1,   Catalase↑, 36,   Fenton↓, 1,   GPx↓, 1,   GPx↑, 20,   GPx3↑, 1,   GPx4↑, 1,   GSH↑, 24,   GSR↑, 6,   GSTs↑, 9,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 18,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 24,   MDA↓, 22,   MPO↓, 4,   MPO↑, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 40,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 93,   ROS↑, 1,   mt-ROS?, 1,   SOD↑, 37,   SOD1↑, 2,   SOD2↑, 3,   TBARS↓, 2,   TOS↓, 1,   uricA↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   PDH↑, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 4,   5LO↝, 1,   ALAT↓, 15,   AMPK↓, 1,   AMPK↑, 6,   p‑AMPK↑, 1,   ATP↑, 2,   cytoP450↓, 1,   glucose↓, 5,   GlucoseCon↑, 3,   Glycolysis↑, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   H2S↑, 1,   HK1↑, 1,   LDL↓, 4,   lipidLev↓, 1,   NADPH↓, 2,   NADPH↑, 1,   PDKs↓, 1,   SIRT1↑, 8,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 9,   ASC?, 1,   ASC↓, 1,   BAD↓, 1,   BAX↓, 6,   Bax:Bcl2↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 3,   Bcl-xL↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp3?, 1,   Casp3↓, 14,   cl‑Casp8↑, 1,   Casp9↓, 4,   Cyt‑c↓, 4,   Fas↓, 1,   Ferroptosis↓, 2,   IAP1↓, 1,   iNOS↓, 10,   iNOS↑, 2,   p38↓, 3,   p38↑, 1,   Pyro?, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   Akt↑, 6,   p‑Akt↑, 2,   AKT1↑, 1,   CREB↑, 1,   EGFR↓, 1,   ERK↓, 2,   ERK↑, 1,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IKKα↑, 1,   IκB?, 1,   IκB↓, 1,   JAK2↓, 1,   JAK2↑, 2,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 2,   p‑LIMK1↑, 1,   MAPK↓, 8,   MAPK↑, 3,   mTOR↓, 4,   mTOR↑, 2,   P70S6K↓, 1,   PI3K↓, 8,   PI3K↑, 5,   PKA↑, 1,   PKCδ↓, 2,   PKCδ↑, 1,   PTEN↑, 1,   Sp1/3/4↓, 1,   Sp1/3/4↑, 1,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cMyc↓, 2,   HDAC↓, 1,   OCT4↓, 1,   other↓, 2,   other↑, 6,   other↝, 4,   SOX18↑, 1,   SOX9↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSP90↑, 1,   HSPs↑, 1,   PERK↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,   DNAdam↓, 3,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↓, 1,   CD133↑, 1,   Diff↑, 2,   FGF↑, 2,   IGF-1↓, 1,   IGFBP3↑, 1,   MSCs↑, 1,   neuroG↑, 1,   TumCP↓, 3,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↑, 4,   Ca+2↝, 1,   Cartilage↑, 2,   p‑Cofilin↑, 1,   COL1↑, 1,   COL2A1↑, 1,   COL3A1↓, 1,   FAK↑, 1,   ITGB1↑, 1,   p‑MLC2/MYL9↑, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP2↑, 2,   MMP3↓, 1,   MMP9↓, 6,   MMP9↑, 3,   MMPs↑, 1,   MYPT1 / PPP1R12A↑, 1,   p‑MYPT1 / PPP1R12A↑, 1,   N-cadherin↑, 2,   PAI-1/SERPINE1↓, 1,   PDGF↑, 1,   Rac1↑, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↑, 1,   SLIT2↑, 1,   SMAD4↑, 1,   SMAD5↑, 1,   TGF-β↓, 3,   TGF-β↑, 3,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   uPA↓, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   angioG↑, 15,   angioG↝, 1,   CD31/PECAM-1↓, 2,   CD31/PECAM-1↑, 2,   E-sel↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 5,   Hif1a↑, 6,   Hif1a∅, 1,   NO↓, 14,   NO↑, 3,   VCAM-1↓, 6,   VEGF↓, 22,   VEGF↑, 32,   VEGFR2/KDR/Flk1↓, 1,   VEGFR2/KDR/Flk1↑, 1,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 9,   BBB↝, 1,   GLUT2↑, 1,   GLUT3↑, 3,   GLUT4↑, 3,   MMP↑, 6,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 1,   OATPs↓, 1,   OCLN↓, 1,   TRPC1↓, 1,   VGCC↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 29,   COX2/PTGS2↑, 1,   CXCR4↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 5,   IFN-γ↓, 3,   IL1↓, 4,   IL1↑, 1,   IL10↓, 3,   IL10↑, 9,   IL12↓, 2,   IL13↓, 1,   IL17↓, 3,   IL18↓, 3,   IL1β↓, 20,   IL2↓, 3,   IL2↑, 1,   IL23↓, 1,   IL4↓, 6,   IL4↑, 1,   IL5↓, 3,   IL6↓, 31,   IL6↑, 1,   IL8↓, 4,   Imm↑, 5,   Imm⇅, 1,   Inflam?, 1,   Inflam↓, 89,   Inflam↑, 1,   IRF3↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 3,   MyD88↓, 2,   NF-kB↓, 43,   NF-kB↑, 1,   NLRP3↓, 9,   p65↓, 1,   PGE2↓, 13,   PGE2↑, 2,   RAGE↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 5,   TLR4∅, 1,   TNF-α↓, 34,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 1,   AChE↓, 12,   ADAM10↑, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 8,   ChAT↑, 1,   GABA↑, 1,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 4,   PSD95↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 2,   Aβ↓, 13,   Aβ42↓, 1,   BACE/β-secretase↓, 4,   tau↓, 3,   p‑tau↓, 8,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   CYP19↓, 1,   END↑, 1,   Estro↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 32,   BioAv↑, 24,   BioAv↝, 9,   BioEnh↑, 2,   CompStab↑, 2,   Dose↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 9,   eff↓, 1,   eff↑, 11,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 3,   P-gp/ABCB1↓, 1,   P450↓, 2,   selectivity↑, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALP↓, 5,   ascitic↓, 1,   AST↓, 18,   BMD↑, 2,   BP↓, 2,   p‑BRCA1↑, 1,   BUN↓, 1,   creat↓, 1,   CRP↓, 4,   EGFR↓, 1,   IL6↓, 31,   IL6↑, 1,   LDH↓, 7,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 1,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AirwayM↓, 1,   Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 16,   AntiArt↑, 7,   AntiCan↓, 1,   AntiCan↑, 8,   antiD↓, 1,   AntiDiabetic↑, 14,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↑, 1,   cardioP↑, 32,   chemoP↑, 8,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 18,   diuretic↑, 1,   hepatoP↑, 31,   Learn↑, 2,   memory↑, 21,   motorD↑, 4,   Mucositis↓, 1,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 58,   Obesity↓, 9,   OS↑, 2,   Pain↓, 5,   QoL↑, 1,   radioP↑, 5,   RenoP↓, 1,   RenoP↑, 8,   Stroke↓, 6,   toxicity↓, 22,   toxicity↑, 2,   toxicity↝, 6,   toxicity∅, 9,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 3,   AntiViral↑, 10,   Bacteria↓, 16,   Bacteria↑, 1,   GutMicro↑, 13,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 437

Scientific Paper Hit Count for: VEGF, Vascular endothelial growth factor
17 Thymoquinone
16 Apigenin (mainly Parsley)
15 Curcumin
14 Magnetic Fields
13 EGCG (Epigallocatechin Gallate)
12 Resveratrol
11 Betulinic acid
11 Sulforaphane (mainly Broccoli)
10 Quercetin
10 Garcinol
9 Baicalein
9 Berberine
9 Chrysin
8 Silver-NanoParticles
8 Propolis -bee glue
8 Fisetin
8 Kaempferol
7 Artemisinin
7 Boswellia (frankincense)
7 Silymarin (Milk Thistle) silibinin
6 Radiotherapy/Radiation
6 Fucoidan
6 Luteolin
6 Melatonin
5 Beta-Caryophyllene
5 Chlorogenic acid
5 Ellagic acid
5 Emodin
5 Formononetin
5 Gambogic Acid
5 Hydrogen Gas
5 Honokiol
4 Cisplatin
4 Ashwagandha(Withaferin A)
4 Bevacizumab (brand Avastin)
4 Caffeic acid
4 Cinnamon
4 Deguelin
4 D-limonene
4 Ferulic acid
4 Isoliquiritigenin
4 Juglone
4 Lycopene
4 Matrine
4 methylseleninic acid
4 Methylsulfonylmethane
4 Nimbolide
4 Phenethyl isothiocyanate
3 Alpha-Lipoic-Acid
3 Chemotherapy
3 Boron
3 Capsaicin
3 Carvacrol
3 Crocetin
3 Diindolylmethane
3 Eugenol
3 Flaxseed/Linseed
3 Ginkgolide B
3 iodine
3 phytic acid, Inositol hexakisphosphate
3 Licochalcone A
3 Magnolol
3 mebendazole
3 Naringin
3 Piperine
3 Selenite (Sodium)
2 Biochanin A
2 Thymol-Thymus vulgaris
2 Celecoxib
2 Celastrol
2 chaetocin
2 Cucurbitacin
2 Ursolic acid
2 Diclofenac
2 Gallic acid
2 Gemcitabine (Gemzar)
2 Genistein (soy isoflavone)
2 Ginger/6-Shogaol/Gingerol
2 Gossypol/AT-101
2 Proanthocyanidins
2 Hydroxycinnamic-acid
2 HydroxyTyrosol
2 Hyperoside
2 MCT, metronomic chemo
2 lambertianic acid
2 Licorice
2 SDG/lignans
2 Phenylbutyrate
2 Piperlongumine
2 Rosmarinic acid
2 Shikonin
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 Annona atemoya Seed Extract
1 Auranofin
1 Astragalus
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 Andrographis
1 Isovitexin
1 Ascorbyl Palmitate
1 Astaxanthin
1 Aloe anthraquinones
1 beta-glucans
1 immunotherapy
1 Baicalin
1 Berbamine
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Centella asiatica / Gotu kola → asiaticoside
1 chitosan
1 Coenzyme Q10
1 Vitamin E
1 Carvone
1 Dandelion Root
1 Ginkgo biloba-EGb 761
1 Docetaxel
1 Bortezomib
1 olaparib/LYNPARZA
1 Paclitaxel/Taxol
1 Ginkgetin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Grapeseed extract
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 Indole-3-carbinol
1 Inositol
1 Extracorporeal Shock Wave Therapy
1 isoflavones
1 isoorientin
1 itraconazole
1 Lactoferrin/Talactoferrin
1 Methyl Jasmonate
1 vp16, etoposide
1 Moringa oleifera
1 tamoxifen
1 Mistletoe/Viscum album Extracts
1 Mushroom Shiitake, AHCC
1 Myricetin
1 Niclosamide (Niclocide)
1 Neem
1 Oleuropein
1 Marjoram (Origanum majorana)
1 Plumbagin
1 VitK3,menadione
1 Psoralidin
1 Pterostilbene
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Sanguinarine
1 Salvia miltiorrhiza
1 Theobromine
1 Aflavin-3,3′-digallate
1 Urolithin
1 Vitamin D3
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:334  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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