β-catenin/ZEB1 Cancer Research Results

β-catenin/ZEB1, β-catenin/ZEB1: Click to Expand ⟱

Source: HalifaxProj (inactivate)

Type:

β-catenin and ZEB1 are two important proteins that play significant roles in cancer biology, particularly in the processes of cell adhesion, epithelial-mesenchymal transition (EMT), and tumor progression.
β-catenin is a key component of the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and survival. It also plays a role in cell-cell adhesion by linking cadherins to the actin cytoskeleton.
Role in Cancer: ZEB1 is often upregulated in cancer and is associated with increased invasiveness and metastasis. It can repress epithelial markers (like E-cadherin) and promote mesenchymal markers (like N-cadherin and vimentin), facilitating the transition to a more aggressive cancer phenotype.

(MMP)-2 and MMP-9, which are the down-stream targets of β-catenin and play a crucial role in cancer cell metastasis.

Scientific Papers found: Click to Expand⟱

3397-

TQ,

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

-

Review,

CRC,

NA

6-112uM (table 1)

ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,

3427-

TQ,

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

-

in-vitro,

Var,

NA

ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,

1020-

UA,

Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/β-Catenin Pathway

-

in-vitro,

Melanoma,

RPMI-8226

β-catenin/ZEB1↓, TCF↓, cMyc↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Casp7↑,

4837-

Uro,

Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review

-

Review,

Var,

NA

AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,

1820-

VitK3,

Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells

-

in-vitro,

CRC,

SW480

-

in-vitro,

CRC,

SW-620

selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,

4888-

ZER,

5-FU,

Modulation of the tumor microenvironment by zerumbone and 5-fluorouracil in colorectal cancer by target in cancer-associated fibroblasts

-

in-vitro,

CRC,

CT26

TumVol↓, *tumCV↓, survivin↓, β-catenin/ZEB1↓, Vim↓,

Showing Research Papers: 251 to 256 of 256
Prev Page 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 256

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4, Catalase↓, 2, Catalase↑, 1, ENOX2↓, 1, GPx↓, 1, GPx↑, 4, GPx4↓, 6, GPx4↝, 1, GSH↓, 13, GSH↑, 3, GSH∅, 1, GSR↓, 1, GSR↑, 2, GSTs↓, 1, GSTs↑, 2, GSTs↝, 1, H2O2↓, 1, HO-1↓, 3, HO-1↑, 9, HO-2↑, 1, Iron↑, 2, c-Iron↑, 1, lipid-P?, 1, lipid-P↓, 6, lipid-P↑, 5, MDA↓, 2, MDA↑, 2, MPO↓, 1, NADH↓, 2, NQO1↓, 1, NQO1↑, 2, NRF2↓, 5, NRF2↑, 9, NRF2↝, 1, p‑NRF2↓, 1, PAO↑, 1, Prx4↑, 1, PYCR1↓, 1, ROS?, 1, ROS↓, 13, ROS↑, 74, ROS⇅, 4, ROS↝, 2, i-ROS↑, 1, mt-ROS↑, 2, SOD↓, 3, SOD↑, 4, SOD2↓, 2, TAC?, 1, TrxR↓, 3, TrxR1↓, 1, VitC↓, 1, VitE↓, 1, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1, Tf↓, 2,

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 5, CDC2↑, 1, CDC25↓, 3, compI↓, 2, compII↓, 1, compIII↓, 1, compIV↓, 1, compV↓, 2, EGF↓, 1, ETC↓, 3, ETC↑, 1, Insulin↓, 1, mitResp↓, 3, mtDam↑, 5, OCR↓, 4, OXPHOS↓, 3, OXPHOS↑, 1, PDH↝, 1, SIRT3↓, 1, SIRT3↑, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2, ACC↑, 1, ACLY↓, 1, ACSL4↑, 2, ALAT↓, 2, ALAT↝, 1, AMACR↓, 1, AMPK?, 1, AMPK↓, 1, AMPK↑, 19, ATP↓, 4, CAIX/CA9↓, 1, ECAR↓, 1, FAO↓, 1, FASN↓, 4, G6PD↓, 1, GLO-I↓, 1, GLS↓, 1, glucose↝, 1, GlucoseCon↓, 2, GlucoseCon∅, 1, Glycolysis↓, 15, GSK‐3β↓, 16, GSK‐3β↑, 9, GSK‐3β↝, 1, p‑GSK‐3β↓, 9, HK1↓, 1, HK2↓, 8, HMG-CoA↓, 1, lactateProd↓, 3, lactateProd↑, 1, lactateProd∅, 1, LDHA↓, 6, lipoGen↓, 1, MCT4↓, 1, NADH:NAD↓, 1, NADPH↓, 1, NADPH↑, 2, PDK1 / PDPK1↓, 4, p‑PDK1 / PDPK1↓, 1, PKM2↓, 5, PKM2↑, 1, PKM2:PKM1↓, 2, SCD1↓, 1, SIRT1↓, 7, SIRT1↑, 4, SIRT2↓, 1, SREBP1/SREBF1↓, 1, SREBP2↓, 1, SSAT↑, 1, TCA↑, 1, Warburg↓, 5,

Cell Death(tgid=5) ⓘ

AIF↑, 2, APAF1↑, 5, Apoptosis?, 1, Apoptosis↓, 1, Apoptosis↑, 86, Apoptosis↝, 1, mt-Apoptosis↑, 2, ASC↓, 1, ASK1↑, 2, aSmase↝, 1, BAD↑, 2, Bak↑, 4, BAX↓, 2, BAX↑, 38, BAX↝, 1, Bax:Bcl2↑, 12, Bcl-2↓, 44, Bcl-2↑, 4, Bcl-2↝, 1, Bcl-xL↓, 6, Bcl-xL↝, 1, BID↓, 1, BID↑, 3, BIM↓, 1, BIM↑, 5, Casp↓, 1, Casp↑, 15, cl‑Casp↑, 1, Casp1↓, 1, Casp1↑, 1, Casp10↑, 1, Casp12?, 1, Casp12↑, 1, cl‑Casp12↑, 1, Casp3↓, 3, Casp3↑, 48, Casp3↝, 1, cl‑Casp3↑, 13, proCasp3↓, 1, Casp7↑, 8, cl‑Casp7↑, 1, Casp8↑, 14, cl‑Casp8↑, 2, Casp9↑, 30, cl‑Casp9↑, 5, CellShr↑, 1, cFLIP↓, 3, CSR1↑, 1, Cyt‑c↓, 1, Cyt‑c↑, 34, Cyt‑c↝, 1, Diablo↑, 5, DR5↑, 17, FADD↑, 1, Fas↓, 1, Fas↑, 11, FasL↑, 2, Ferroptosis↑, 9, HEY1↓, 1, IAP1↓, 2, IAP2/BIRC3↓, 1, cl‑IAP2/BIRC3↑, 1, ICD↑, 2, iNOS↓, 8, JWA↑, 1, Mcl-1↓, 15, Mcl-1↑, 1, MDM2↓, 4, p‑MDM2↓, 1, MOMP↑, 2, Necroptosis↑, 1, p38↓, 1, p38↑, 10, p‑p38↑, 2, PUMA↑, 1, PUMA⇅, 1, Pyro↑, 1, survivin↓, 32, TNFR 1↑, 1, TRAIL↑, 4, TRAILR↑, 1, TumCD↓, 1, TumCD↑, 5, XIAP↓, 14, XIAP↝, 1, YAP/TEAD↓, 5, β-TRCP↑, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 82, Akt↝, 1, p‑Akt↓, 17, AKT1↓, 1, AMPKα↑, 1, CIP2A↓, 1, CK2↓, 3, cMET↓, 2, p‑cMET↑, 1, CREB↓, 2, DDIT4↑, 1, EF-1α↓, 1, EGFR↓, 21, EGFR↑, 1, EGFR↝, 1, EphB4↓, 1, ERK↓, 25, ERK↑, 5, p‑ERK↓, 7, FGFR1↓, 1, FLT4↓, 1, HER2/EBBR2↓, 3, HGF/c-Met↓, 1, Hippo↝, 1, IGF-1R↓, 4, IGFR↓, 1, p‑IGFR↓, 1, IKKα↓, 7, JAK↓, 6, JAK1↓, 3, JAK2↓, 4, JNK↓, 4, JNK↑, 10, JNK↝, 1, p‑JNK↓, 1, p‑JNK↑, 1, p‑MAP2K1/MEK1↓, 1, MAPK?, 1, MAPK↓, 16, MAPK↑, 9, p‑MAPK↓, 1, p‑MAPK↑, 1, MEK↓, 3, Mst1↑, 1, mTOR↓, 51, mTOR↝, 1, p‑mTOR↓, 4, mTORC2↓, 1, NRAS↓, 1, p‑p42↓, 1, p‑p42↑, 1, p‑p70S6↓, 1, P70S6K↓, 3, PDGFR-BB↓, 1, p‑PDGFR-BB↓, 1, PI3K↓, 62, PI3K↝, 1, p‑PI3K↓, 3, PIAS-3↑, 1, PKCδ↓, 4, PKCδ↑, 1, PP2A↑, 2, PRAS40↑, 1, PTEN↓, 1, PTEN↑, 13, PTEN↝, 1, Raf↓, 3, e-Raf↓, 1, c-Raf↓, 1, RAS↓, 6, Sp1/3/4↓, 8, Src↓, 1, p‑Src↓, 1, STAT↓, 1, STAT3↓, 49, p‑STAT3↓, 3, STAT5↓, 1, STAT6↓, 2, p‑STAT6↓, 1, THEM4/CTMP↑, 1, TSC2↑, 2,

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1, ATF3↑, 1, ATF4↑, 5, ATF4↝, 1, CBP↓, 1, cJun↓, 6, cJun↑, 1, p‑cJun↑, 1, cMyc↓, 41, DNMT1↓, 8, DNMT3A↓, 2, DNMTs↓, 4, FOXM1↓, 1, FOXO↑, 1, FOXO1↓, 2, FOXO1↑, 1, FOXO3↓, 1, FOXO3↑, 4, FOXO4↑, 1, H3↓, 1, H3↑, 2, ac‑H3↑, 1, H4↓, 1, H4↑, 1, ac‑H4↑, 1, HATs↓, 3, HATs↑, 2, HDAC↓, 8, HDAC1↓, 3, HDAC3↓, 2, HDAC4↓, 2, HDAC8↓, 1, HES1↓, 1, JPT1/HN1↓, 1, LINC01116↓, 1, miR-107↑, 2, miR-10b-5p↓, 1, miR-130a↓, 2, miR-133a-3p↑, 1, miR-139-5p↑, 2, miR-155↓, 2, miR-182-5p↓, 1, miR-192-5p↑, 1, miR-200b↑, 1, miR-200c↑, 2, miR-205↑, 1, miR-21↓, 6, miR-210↓, 1, miR-218↑, 1, miR-22↑, 1, miR-224↓, 2, miR-29b↓, 1, miR-340↓, 2, miR-34a↑, 5, miR-384↑, 1, miR-422a↑, 2, miR-592↑, 1, miR-99↑, 1, Myc↓, 3, MYCN↓, 1, n-MYC↓, 2, NDRG1↑, 1, OCT4↓, 9, other↓, 2, other↑, 2, other↝, 3, PCAF↓, 1, Shc↓, 1, SOX2↓, 7, SOX4↓, 3, SOX4↑, 1, SPP1↓, 1, TCF-4↓, 2, tumCV?, 1, tumCV↓, 20,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 13, cl‑CHOP/DDIT3↑, 1, eIF2α↓, 2, eIF2α↑, 1, p‑eIF2α↑, 3, ER Stress↑, 23, Erlin1↑, 1, ERStress↑, 1, GRP78/BiP↓, 2, GRP78/BiP↑, 5, Hsc70↓, 1, HSF1↓, 1, HSP27↓, 4, HSP70/HSPA5↓, 4, HSP70/HSPA5↑, 1, HSP90↓, 6, HSP90↑, 1, HSPs↓, 1, IRE1↑, 3, PERK↑, 3, Proteasome↓, 1, UPR↑, 5, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1, ATG16L1↑, 1, ATG3↑, 1, ATG5↑, 4, ATG7↑, 3, Beclin-1/ATG6↓, 2, Beclin-1/ATG6↑, 7, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3B-II↑, 1, LC3I↑, 1, LC3II↑, 10, LC3s↓, 1, p62↓, 3, p62↑, 2, RUBCN↓, 1, SESN2↑, 1, TumAuto↓, 1, TumAuto↑, 17, mt-TumAuto↑, 1, ULK1/ATG1↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1, DFF45↑, 1, DNA-PK↓, 1, DNAdam↓, 1, DNAdam↑, 19, DNArepair↓, 2, ERCC3↑, 1, hTERT/TERT↓, 3, p16↑, 2, P53?, 1, P53↓, 3, P53↑, 31, P53↝, 1, ac‑P53↑, 1, PARP↑, 6, cl‑PARP↑, 26, proPARP↓, 1, PARP1↓, 1, PARP1↑, 2, cl‑PARP1↑, 1, PCNA↓, 12, PCNA↑, 1, SIRT6↓, 1, Telomerase↓, 8, TOP1↓, 4, TOP2↓, 5, TOP2↑, 1, TP53↑, 1, UHRF1↓, 1, XRCC1↓, 1, γH2AX↓, 1, γH2AX↑, 3, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4, CDK1↑, 1, CDK2↓, 11, CDK2↑, 1, CDK4↓, 19, CDK4↑, 1, CDK6↓, 9, CDK6↑, 1, CDK8↓, 1, CHK1↓, 2, p‑CHK1↑, 1, Chk2↓, 2, Cyc↓, 1, Cyc↝, 1, cycA1/CCNA1↓, 3, CycB/CCNB1↓, 5, CycB/CCNB1↑, 1, cycD1/CCND1↓, 58, cycD1/CCND1↝, 1, CycD3↓, 1, cycE/CCNE↓, 9, E2Fs↓, 4, Ki-67↓, 11, MAD↓, 1, P21?, 1, P21↑, 28, P21↝, 1, p27/CDKN1B↑, 10, pRB↑, 1, p‑pRB↓, 2, RB1↑, 1, p‑RB1↓, 6, Securin↓, 2, TAp63α↑, 1, TumCCA↓, 3, TumCCA↑, 76,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2, p‑4E-BP1↓, 1, ALDH↓, 4, ALDH1A1↓, 5, AXIN1↓, 1, AXIN1↑, 2, Axin2↓, 1, Axin2↑, 1, CD133↓, 14, CD24↓, 3, CD34↓, 1, CDX2↓, 1, CEBPB↓, 1, cFos↓, 6, cFos↑, 1, CLOCK↓, 1, cMYB↓, 1, CSCs↓, 49, CSCs↑, 1, Diff↑, 3, EP2↓, 1, EP4/PTGER4↓, 1, FBXW7↝, 1, Gli↓, 2, Gli1↓, 9, HH↓, 10, HMGCR↓, 1, IGF-1↓, 3, IGFBP1↑, 1, IGFBP3↑, 1, JAG1↓, 1, Jun↓, 1, Ki-67↓, 11, Let-7↑, 2, LRP6↓, 6, p‑LRP6↓, 2, mTORC1↓, 5, Nanog↓, 9, Nestin↓, 3, NKD2↑, 2, NOTCH↓, 17, NOTCH⇅, 1, NOTCH1↓, 8, NOTCH1↝, 1, NOTCH2↓, 2, NOTCH3↓, 3, p300↓, 3, Piezo1↑, 1, PTCH1↓, 3, Shh↓, 8, Smo↓, 5, STAT1↓, 1, p‑STAT1↓, 1, TOPflash↓, 2, TumCG↓, 40, TumCP?, 1, TumCP↓, 76, TumCP↑, 1, Wnt↓, 123, Wnt↑, 1, Wnt/(β-catenin)↓, 2,

Migration(tgid=13) ⓘ

AGRN↓, 1, AntiAg↓, 1, AntiAg↑, 2, AP-1↓, 12, AP-1↝, 2, APC↑, 1, AXL↓, 1, Ca+2↓, 2, Ca+2↑, 11, Ca+2↝, 1, cal2↑, 2, Cal9↑, 1, CCN2/CTGF↓, 2, Cdc42↓, 1, Chl↓, 1, Cofilin↓, 1, COL1↓, 1, COL3A1↓, 1, DLC1↑, 1, E-cadherin↓, 9, E-cadherin↑, 45, EMT↓, 70, F-actin↓, 1, FAK↓, 7, p‑FAK↓, 1, fascin↓, 2, Fibronectin↓, 3, GLI2↓, 3, GLI3↑, 1, GnT-V↝, 1, heparanase↝, 1, ITGA5↓, 1, ITGB1↓, 2, ITGB4↓, 1, KRAS↓, 1, LEF1↓, 5, MALAT1↓, 4, MET↓, 2, MET↑, 1, p‑MET↓, 1, MMP-10↓, 1, MMP1↓, 4, MMP14↓, 1, MMP15↓, 1, MMP16↓, 2, MMP2↓, 45, MMP2↑, 1, MMP2↝, 1, MMP3↓, 3, MMP7↓, 10, MMP9↓, 49, MMPs↓, 18, N-cadherin↓, 29, N-cadherin↑, 1, NCAM↓, 1, NM23↑, 1, p‑p44↓, 1, p‑p44↑, 1, p‑pax↓, 1, PDGF↓, 1, Rac1↓, 1, Rho↓, 3, ROCK1↓, 3, Sharpin↓, 1, Slug↓, 20, Smad1↓, 1, SMAD2↓, 1, p‑SMAD2↓, 3, SMAD3↓, 2, p‑SMAD3↓, 2, Snail↓, 36, TET1↑, 2, TGF-β↓, 10, TGF-β↑, 1, TGF-β1↓, 1, TIMP1↓, 1, TIMP1↑, 1, TIMP2↓, 2, TIMP2↑, 2, TRIB3↑, 2, TSC1↑, 1, TSP-1↑, 3, TumCA↓, 2, TumCI↓, 56, TumCMig↓, 59, TumCMig↑, 1, TumMeta↓, 39, TumMeta↑, 3, TumPF↓, 1, Twist↓, 13, Tyro3↓, 1, uPA↓, 14, uPAR↓, 1, UroPA↓, 1, Vim↓, 47, Vim↑, 2, vinculin↓, 1, Zeb1↓, 15, ZEB2↑, 1, β-catenin/ZEB1↓, 235, β-catenin/ZEB1↑, 6, β-catenin/ZEB1↝, 1, p‑β-catenin/ZEB1↓, 2, p‑β-catenin/ZEB1↑, 1, cl‑β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 36, angioG↑, 2, CCN1/CYR61↓, 1, CD31/PECAM-1↓, 1, ECM/TCF↓, 1, HIF-1↓, 2, Hif1a↓, 25, Hif1a↝, 1, LOX1↓, 1, LymphAG↓, 1, NO↓, 1, NO↑, 1, NO↝, 1, VCAM-1↓, 2, VEGF↓, 47, VEGF↑, 1, VEGF↝, 1, VEGFR1↓, 1, VEGFR2/KDR/Flk1↓, 8,

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1, BBB↓, 1, BBB↑, 1, BBB∅, 1, CLDN1↓, 5, CLDN1↑, 1, CLDN2↓, 1, CTR1↑, 1, GLUT1↓, 8, MMP↓, 35, MPT↑, 3, NHE1↓, 1, ZO-1↓, 1, ZO-1↑, 6,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2, CD44↓, 19, CD44↑, 1, COX1↓, 1, COX2/PTGS2↓, 47, COX2/PTGS2↑, 1, COX2/PTGS2↝, 1, CXCL1↓, 1, CXCL12↓, 1, CXCR2↓, 2, CXCR4↓, 12, DR4↑, 6, HMGB1↓, 1, ICAM-1↓, 3, IFN-γ↓, 2, IFN-γ↑, 2, IL1↓, 1, IL1↑, 1, IL10↓, 3, IL12↓, 2, IL12↑, 1, IL1α↓, 1, IL1β↓, 7, IL2↓, 1, IL2↑, 6, IL4↓, 1, IL4↑, 1, IL6↓, 19, IL6↝, 1, IL8↓, 3, Imm↑, 11, Imm↝, 1, Inflam↓, 16, LIF↑, 1, M2 MC↓, 1, MCP1/CCL2↓, 3, MCT1↓, 1, MDSCs↓, 1, MIP-1β↑, 1, MIP2↓, 1, NF-kB?, 2, NF-kB↓, 79, NF-kB↑, 1, NF-kB↝, 1, p‑NF-kB↑, 1, NK cell↑, 2, NLRP3↓, 1, NLRP3↑, 1, p50↓, 2, p65↓, 4, p65↑, 1, p‑p65↓, 1, PD-1↓, 3, PD-L1↓, 4, PGE2↓, 14, PSA↓, 3, PSA↝, 1, RAGE↓, 1, SOCS-3↑, 1, SOCS1↑, 1, TCF↓, 10, TCF↑, 1, TCF7/TCF1↓, 2, TNF-α↓, 11, TNF-α↑, 3, TNF-α↝, 1, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1, pH↓, 1, PLC↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, ADAM10↓, 1, PTN↓, 1,

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1, AhR↓, 1, AR↓, 10, AR↝, 1, ER-α36↓, 1, Estro↝, 1, PPARα↓, 1, PPARα↑, 1, PPARα↝, 1, PPARγ↓, 1, PPARγ↑, 4,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4, BioAv↓, 14, BioAv↑, 13, BioAv↝, 6, BioEnh?, 1, BioEnh↑, 3, ChemoSen↑, 76, ChemoSen⇅, 1, ChemoSen∅, 1, CompStab↓, 2, CYP1A1↓, 1, CYP1A1↑, 1, CYP1B1↑, 1, Dose?, 1, Dose↑, 3, Dose↝, 17, Dose∅, 4, eff↓, 9, eff↑, 27, eff↝, 6, GSTA1↑, 1, Half-Life↓, 7, Half-Life↝, 2, MDR1↓, 5, MRP1/ABCC1↓, 4, P-gp/ABCB1↓, 13, P450↓, 2, P450↝, 1, RadioS↑, 26, selectivity↑, 27, selectivity↝, 1, Synergy↑, 43, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2, ALAT↝, 1, ALB↑, 1, ALP↓, 1, ALP↝, 1, AR↓, 10, AR↝, 1, ascitic↓, 1, AST?, 1, AST↓, 1, AST↝, 1, CEA↓, 2, DBIL↓, 1, E6↓, 2, E7↓, 2, EGFR↓, 21, EGFR↑, 1, EGFR↝, 1, Ferritin↓, 1, FOXM1↓, 1, HEC1↓, 1, HER2/EBBR2↓, 3, hTERT/TERT↓, 3, IBIL↓, 1, IL6↓, 19, IL6↝, 1, KRAS↓, 1, LDH↓, 3, Myc↓, 3, NOS2↓, 1, NSE↓, 1, PD-L1↓, 4, PSA↓, 3, PSA↝, 1, RAGE↓, 1, TBIL↓, 1, TP53↑, 1, TRIB3↑, 2,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 23, antiD↑, 1, antiNeop↑, 3, AntiTum↑, 7, cachexia↓, 2, cardioP↑, 4, chemoP↑, 14, chemoPv↑, 14, ChemoSideEff↓, 4, fatigue↓, 1, FTO↑, 1, hepatoP↑, 3, IMPDH1↓, 1, IMPDH2↓, 1, Mucositis↓, 1, neuroP↑, 3, NKG2D↑, 1, Obesity↓, 1, OS↑, 7, QoL↑, 5, radioP↑, 4, RenoP↑, 2, Risk↓, 8, Sleep↑, 1, Symptoms∅, 1, toxicity↓, 7, toxicity↑, 1, toxicity↝, 2, TumVol↓, 7, TumVol∅, 1, TumW↓, 5, TumW∅, 1, Wound Healing↓, 1,

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,
Total Targets: 874

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1, antiOx↓, 1, antiOx↑, 29, Catalase↑, 9, Fenton↓, 1, GPx↑, 6, GPx4↑, 2, GSH↑, 7, GSTs↑, 4, H2O2↑, 1, HDL↓, 1, HO-1?, 1, HO-1↑, 10, i-Iron↓, 1, lipid-P↓, 7, MDA↓, 7, MPO↓, 1, NOX↓, 1, NOX4↓, 1, NRF2↑, 18, Prx↑, 1, RNS↓, 1, ROS?, 1, ROS↓, 30, ROS↑, 2, mt-ROS↓, 1, SOD↑, 11, SOD1↑, 1, SOD2↑, 1, TAC↑, 2, TBARS↓, 1, Trx1↑, 1, VitC↑, 1, VitE↓, 1, xCT/SLC7A11↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1, SIRT3↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1, 5LO↓, 2, ALAT↓, 3, AMPK↑, 2, ATP↑, 1, cytoP450↓, 1, FABP4↓, 1, FASN↓, 1, GSK‐3β↓, 5, LDL↓, 1, NADPH↓, 1, SIRT1↑, 1, SIRT1↝, 1, SREBP1/SREBF1↓, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1, BAX↓, 1, Bcl-2↑, 3, Bcl-xL↑, 1, Casp3?, 1, Casp3↓, 4, Casp9↓, 2, Ferroptosis↓, 2, iNOS↓, 1, p38↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2, Akt↝, 1, p‑Akt↓, 1, p‑Akt↑, 2, p‑CREB↑, 2, ERK↓, 1, ERK↑, 2, JAK2↑, 1, JNK↓, 1, MAPK↓, 4, MAPK↑, 1, mTOR↓, 1, mTOR↑, 1, PI3K↑, 2, PKCδ↓, 1, STAT↓, 1, STAT3↓, 1, STAT3↑, 2, p‑STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

HOTAIR↑, 1, miR-34b-5p↓, 1, other↝, 1, RUNX2↑, 1, TCF-4↓, 1, tumCV↓, 2,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, GRP78/BiP↓, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2, P53↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, CEBPA↓, 1, cFos↑, 1, Diff↑, 2, FGF↑, 1, Ki-67↑, 1, TumCP↓, 1, Wnt↓, 2, Wnt↑, 5,

Migration(tgid=13) ⓘ

AntiAg↑, 2, Ca+2?, 1, Ca+2↓, 1, Ca+2↑, 3, Ca+2↝, 1, E-cadherin↑, 1, EMT↓, 1, FAK↑, 1, LAMs↑, 1, LRP1↑, 1, MMP-10↓, 1, MMP1↓, 1, MMP13↓, 1, MMP2↓, 1, MMP9↓, 3, MUC1↑, 1, OPN↑, 1, Smad1↑, 1, Smad7↑, 1, STAC2↑, 1, TGF-β↓, 1, TIMP1↑, 1, TIMP2↑, 1, TumCI↓, 1, TumCMig↓, 1, Vim↓, 1, α-SMA↓, 1, β-catenin/ZEB1↓, 4, β-catenin/ZEB1↑, 10, β-catenin/ZEB1↝, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2, VCAM-1↓, 1, VEGF↓, 1, VEGF↑, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1, BBB↑, 5, GLUT4↓, 1, IBI↑, 2, MMP↑, 1, MUC19↓, 1, MUC2↓, 1, TRPV1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1, CD4+↑, 1, COX1↓, 2, COX2/PTGS2↓, 6, FOXP3↑, 1, HMGB1↓, 1, ICAM-1↓, 1, IFN-γ↓, 2, IL1↓, 1, IL10↓, 1, IL10↑, 3, IL17↓, 1, IL18↓, 1, IL1β↓, 8, IL23↓, 1, IL4↓, 2, IL4↑, 1, IL6↓, 7, IL8↓, 1, Imm↑, 4, INF-γ↑, 1, Inflam?, 1, Inflam↓, 35, Inflam↑, 1, M2 MC↑, 1, MCP1/CCL2↓, 2, NeuroI↓, 1, NF-kB↓, 10, p‑NF-kB↓, 1, NLRP3↓, 2, PGE2↓, 3, RAGE↓, 1, TLR2↓, 1, TLR4↓, 2, TNF-α↓, 11, Treg lymp↝, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1, Ach↑, 1, AChE↓, 6, BDNF↑, 6, NGF↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, APP↓, 1, Aβ↓, 7, BACE/β-secretase↓, 2, tau↓, 2, p‑tau↓, 2, XO↝, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1, PPARγ↓, 1, PPARγ↑, 1, p‑PPARγ↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 14, BioAv↑, 10, BioAv↝, 9, ChemoSen↑, 1, CompStab↑, 1, Dose↓, 1, Dose↑, 3, Dose↝, 8, eff↑, 4, eff↝, 1, GSTA1↑, 1, Half-Life↓, 2, Half-Life↑, 1, Half-Life↝, 5, Half-Life∅, 1, P-gp/ABCB1↓, 1, Synergy↑, 7,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3, ALP↓, 1, ALP↑, 1, AST↓, 4, BMD↑, 3, CRP↓, 1, IL6↓, 7, IRes↑, 1, LDH↓, 1, LDH↑, 1, OCN↑, 1, RAGE↓, 1, SpO2↑, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, antiAll↑, 4, AntiArt↑, 3, AntiCan↑, 3, AntiDiabetic↑, 7, AntiTum↑, 2, cardioP?, 1, cardioP↑, 4, chemoP↑, 1, chemoPv↑, 5, cognitive↑, 5, diuretic↑, 1, hepatoP↑, 12, Learn↑, 1, memory↑, 11, motorD↑, 1, neuroP↑, 23, Obesity↓, 2, OS↑, 1, Pain↓, 2, radioP↑, 2, RenoP↑, 3, Sleep↑, 1, Stress↓, 1, Stroke↓, 1, toxicity↓, 14, toxicity∅, 2, Weight↑, 1, Wound Healing↑, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2, AntiFungal↑, 2, AntiP↑, 2, AntiViral↑, 4, Bacteria↓, 7, Diar↓, 1, GutMicro↑, 4,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,
Total Targets: 264

Scientific Paper Hit Count for: β-catenin/ZEB1, β-catenin/ZEB1

21 Curcumin
11 EGCG (Epigallocatechin Gallate)
10 Quercetin
9 Matrine
9 Resveratrol
7 Apigenin (mainly Parsley)
7 Fisetin
7 Honokiol
6 Luteolin
6 Sulforaphane (mainly Broccoli)
6 salinomycin
5 Astragalus
5 Berberine
5 Ivermectin
5 Lycopene
5 Magnetic Fields
4 Ashwagandha(Withaferin A)
4 Garcinol
4 isoquercitrin
4 Kaempferol
4 Thymoquinone
3 Allicin (mainly Garlic)
3 Boswellia (frankincense)
3 5-fluorouracil
3 Ginkgetin
3 HydroxyTyrosol
3 phytic acid, Inositol hexakisphosphate
3 Naringin
3 Nimbolide
3 Piperine
2 Cisplatin
2 Isovitexin
2 Artemisinin
2 Baicalein
2 Caffeic acid
2 Propolis -bee glue
2 Capsaicin
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Ursolic acid
2 Dandelion Root
2 Echinacea
2 Hydrogen Gas
2 Indole-3-carbinol
2 isoorientin
2 itraconazole
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Magnolol
2 Melatonin
2 Morin
2 Niclosamide (Niclocide)
2 Piperlongumine
2 Pterostilbene
2 α-Santalol/Sandalwood oil
2 Silymarin (Milk Thistle) silibinin
1 1,8-Cineole
1 3-bromopyruvate
1 Alpha-Lipoic-Acid
1 Anethole/trans-Anethole
1 Chemotherapy
1 Baicalin
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Bufalin/Huachansu
1 Brutieridin–Melitidin Mixture
1 Bromelain
1 Boron
1 brusatol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Coenzyme Q10
1 Crocetin
1 Cyclopamine
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Diindolylmethane
1 Dipyridamole
1 Ellagic acid
1 Gemcitabine (Gemzar)
1 Emodin
1 Ferulic acid
1 flavonoids
1 Fucoidan
1 Grapeseed extract
1 Isobavachalcone
1 Inositol
1 Isoliquiritigenin
1 Vitexin
1 lambertianic acid
1 methylseleninic acid
1 Magnetic Field Rotating
1 Zeolite
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Bacopa monnieri
1 L-Theanine
1 Orlistat
1 Phycocyanin
1 isoflavones
1 Rutin
1 buckwheat sprouts
1 Shikonin
1 Salvia miltiorrhiza
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Urolithin
1 VitK3,menadione
1 Zerumbone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:342  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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