STAT3 Cancer Research Results

STAT3, Signal transducer and activator of transcription 3: Click to Expand ⟱
Source:
Type: Oncogene
Stat3 (Signal Transducer and Activator of Transcription 3) is a transcription factor that plays a crucial role in various cellular processes, including cell growth, survival, differentiation, and immune response.
Stat3 is frequently found to be constitutively activated in many types of cancers, including breast, prostate, lung, and head and neck cancers. (associated with poor prognosis and reduced survival.)

-STAT3 is typically activated by cytokines (such as IL-6) and growth factors binding to their respective receptors.
-Activated STAT3 upregulates the expression of genes that promote cell cycle progression (e.g., cyclin D1) and anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL).
Scientific Papers found: Click to Expand⟱
1140- SIL,    Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth
- in-vitro, PC, AsPC-1 - in-vivo, PC, NA - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCG↓, Glycolysis↓, cMyc↓, STAT3↓, TumCP↓, Weight∅, Strength↑, DNAdam↑, Casp3↑, Casp9↑, GLUT1↓, HK2↓, LDHA↓, GlucoseCon↓, lactateProd↓, PPP↓, Ki-67↓, p‑STAT3↓, cachexia↓,
2192- SK,    Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation
- in-vitro, ESCC, KYSE-510 - in-vitro, ESCC, Eca109 - in-vivo, NA, NA
TumCP↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, p‑PKM2↓, p‑STAT3↓, GLUT1↓, HK2↓, TumW↓,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,
3047- SK,    Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6/STAT3 signaling pathway
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
TumCG↓, p‑STAT3↓, ADAM17↓, Apoptosis↑, Casp3↑, cl‑PARP↑, cycD1/CCND1↓, cycE/CCNE↓, TumCCA↑, JAK1?, p‑JAK1↓, p‑JAK2↓, p‑eIF2α↑, eff↓, ROS↑, IL6↓,
2120- TQ,    STAT3">Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3
- in-vitro, Melanoma, A431
ROS↑, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp7↑, Casp3↑, STAT3↓, cycD1/CCND1↓, survivin↓, eff↓,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, eff↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,
2083- TQ,    Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro
- in-vitro, GC, HGC27 - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vivo, NA, NA
p‑STAT3↓, JAK2↓, c-Src↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, VEGF↓, Casp3?, Casp7?, Casp9?, *toxicity∅, TumVol↓,
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, NA, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,
2106- TQ,    Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy
- Review, Var, NA
Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,
2108- TQ,    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
- Review, Var, NA
HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, survivin↓, COX2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,
1935- TQ,    Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
- Review, OS, NA
Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, ROS↑, P53↑, Twist↓, E-cadherin↑, N-cadherin↓, NF-kB↓, IL8↓, XIAP↓, Bcl-2↓, STAT3↓, MAPK↓, PI3K↓, Akt↓, ERK↓, MMP2↓, MMP9↓, *ROS↓, HO-1↑, selectivity↑, TumCG↓,
3413- TQ,    Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase
- in-vitro, CRC, HCT116
tumCV↓, Apoptosis↓, BAX↑, Bcl-2↓, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, EGFR↓, ROS↑,
3412- TQ,    Thymoquinone induces oxidative stress-mediated apoptosis through downregulation of Jak2/STAT3 signaling pathway in human melanoma cells
- in-vitro, Melanoma, SK-MEL-28 - in-vivo, NA, NA
Apoptosis↑, JAK2↓, STAT3↓, cycD1/CCND1↓, survivin↓, ROS↑, eff↓,
3411- TQ,    Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone
- Review, Var, NA
p‑STAT3↓, cycD1/CCND1↓, JAK2↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MET↓, p‑Akt↓, p‑mTOR↓, CXCR4↓, Bcl-2↓, BAX↑, ROS↑, Cyt‑c↑, Twist↓, Zeb1↓, E-cadherin↑, p‑p38↑, p‑MAPK↑, ERK↑, eff↑, ERK↓, TumCP↓, TumCMig↓, TumCI↓,
3414- TQ,    Thymoquinone induces apoptosis through inhibition of JAK2/STAT3 signaling via production of ROS in human renal cancer Caki cells
- in-vitro, RCC, Caki-1
tumCV↓, Apoptosis↑, P53↑, BAX↑, Cyt‑c↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, p‑STAT3↓, p‑JAK2↓, STAT3↓, survivin↓, cycD1/CCND1↓, ROS↑, eff↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, eff↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2↓, Ki-67↓, COX2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, eff↑, EMT↓, ROS↑, DNMT1↓, eff↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *eff↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3573- TQ,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, Var, NA
NF-kB↓, XIAP↓, PI3K↓, Akt↓, STAT3↓, JAK2↓, cSrc↓, PCNA↓, MMP2↓, ERK↓, Ki-67↓, Bcl-2↓, VEGF↓, p65↓, COX2↓, MMP9↓,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
119- UA,  CUR,  RES,    Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ROS⇅, p‑STAT3↓, Src↓, AMPK↑, GlutMet↑, TCA↑, glut↓,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4842- Uro,    Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, MCF-7 - in-vitro, BC, 4T1
Inflam↓, IL6↓, TNF-α↓, eff↑, STAT3↓, TumCP↓, TumCMig↓,
1216- VitC,    Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer
- in-vitro, Laryn, FaDu - in-vitro, SCC, SCC-154
Iron↝, ROS↑, tumCV↓, Ki-67↓, TumCCA↑, Ferroptosis↑, GSH↓, ROS↑, MDA↑, STAT3↓, GPx4↓, p‑STAT3↓,
2281- VitK2,    The biological responses of vitamin K2: A comprehensive review
- Review, Var, NA
*ROS↓, *12LOX↓, *NF-kB↓, *BMD↑, *hepatoP↑, cycD1/CCND1↓, PKCδ↓, STAT3↓, ERK↑, MAPK↓, ROS↑, PI3K↝, Akt↝, Hif1a↝, *neuroP↑,
1213- VitK2,    Vitamin K2 Inhibits Hepatocellular Carcinoma Cell Proliferation by Binding to 17β-Hydroxysteroid Dehydrogenase 4
- in-vitro, HCC, HepG2
HSD17B4↓, Akt↓, MEK↓, ERK↓, STAT3↓, TumCP↓,

Showing Research Papers: 251 to 276 of 276
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 276

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 3,   HO-1↑, 1,   Iron↝, 1,   MDA↑, 1,   NRF2↑, 1,   ROS↑, 17,   ROS⇅, 5,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   CDC2↓, 1,   CDC25↓, 1,   MEK↓, 2,   mitResp↓, 1,   MMP↓, 4,   Raf↓, 1,   XIAP↓, 6,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 3,   ATG7↑, 1,   cMyc↓, 6,   FAO↑, 1,   FASN↓, 1,   GlucoseCon↓, 2,   glut↓, 1,   GlutMet↑, 1,   Glycolysis↓, 3,   HK2↓, 3,   HSD17B4↓, 1,   lactateProd↓, 3,   LDH↝, 1,   LDHA↓, 1,   PKM2↓, 3,   p‑PKM2↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   PPP↓, 1,   SIRT1↓, 1,   TCA↑, 1,  

Cell Death ⓘ

Akt↓, 8,   Akt↝, 1,   p‑Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 11,   BAX↑, 6,   Bax:Bcl2↑, 1,   Bcl-2↓, 11,   Bcl-2↑, 1,   Bcl-xL↓, 6,   BID↓, 1,   Casp↑, 3,   Casp3?, 1,   Casp3↑, 9,   cl‑Casp3↑, 1,   Casp7?, 1,   Casp7↑, 4,   Casp8↑, 1,   Casp9?, 1,   Casp9↑, 6,   cl‑Casp9↑, 1,   Chk2↓, 1,   Cyt‑c↑, 4,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   IAP1↓, 2,   IAP2↓, 2,   iNOS↓, 2,   JNK↑, 3,   MAPK↓, 3,   MAPK↑, 2,   p‑MAPK↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   Myc↓, 1,   Necroptosis↑, 1,   p27↑, 3,   p38↑, 2,   p‑p38↑, 1,   survivin↓, 10,   Telomerase↓, 1,   TRAIL↑, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,   cSrc↓, 2,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

eIF2α↓, 1,   p‑eIF2α↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3II↑, 2,   p62↓, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   BRCA1↓, 1,   CHK1↓, 1,   CYP1B1↑, 1,   DNAdam↑, 4,   DNMT1↓, 2,   GADD45A↑, 1,   p16↑, 2,   P53↑, 9,   cl‑PARP↑, 7,   PCNA↓, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 13,   cycE/CCNE↓, 1,   E2Fs↓, 1,   E2Fs↑, 1,   P21↓, 1,   P21↑, 5,   TumCCA↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

cMET↓, 1,   CSCs↓, 1,   EMT↓, 2,   ERK↓, 8,   ERK↑, 2,   p‑ERK↓, 1,   FOXO↑, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   HDAC↓, 3,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   mTOR↓, 5,   p‑mTOR↓, 1,   NOTCH↓, 1,   P70S6K↓, 1,   PI3K↓, 6,   PI3K↑, 1,   PI3K↝, 1,   PTEN↑, 3,   RAS↓, 1,   Src↓, 1,   c-Src↓, 1,   STAT3↓, 18,   p‑STAT3↓, 10,   TumCG↓, 3,   Wnt↓, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 1,   CD31↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 4,   ITGA5↓, 1,   Ki-67↓, 5,   MET↓, 1,   MMP2↓, 4,   MMP7↓, 2,   MMP9↓, 6,   MMPs↓, 1,   N-cadherin↓, 4,   PKCδ↓, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 7,   TumMeta↓, 3,   Twist↓, 5,   Vim↓, 3,   Zeb1↓, 3,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   angioG↑, 2,   EGFR↓, 2,   Hif1a↓, 1,   Hif1a↝, 1,   NO↑, 1,   VEGF↓, 7,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 6,   CXCL1↓, 1,   CXCR4↓, 3,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL2↑, 1,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 2,   JAK1?, 1,   p‑JAK1↓, 1,   JAK2↓, 6,   p‑JAK2↓, 2,   NF-kB↓, 9,   p‑NF-kB↑, 1,   NK cell↑, 1,   p65↓, 3,   TNF-α↓, 2,  

Cellular Microenvironment ⓘ

ADAM17↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 5,   Dose↝, 1,   eff↓, 5,   eff↑, 7,   RadioS↑, 3,   selectivity↑, 4,   TET2↑, 1,  

Clinical Biomarkers ⓘ

BRCA1↓, 1,   EGFR↓, 2,   EZH2↓, 1,   GutMicro↑, 1,   IL6↓, 3,   Ki-67↓, 5,   LDH↝, 1,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   Strength↑, 1,   TumVol↓, 1,   TumW↓, 1,   Weight∅, 1,  
Total Targets: 227

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 5,   GPx↑, 5,   GSH↑, 2,   GSTA1↓, 1,   GSTA1↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   MPO↓, 1,   MPO↑, 1,   ROS↓, 4,   SOD↑, 6,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   NAD↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

BAX↓, 1,   Bcl-2↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↑, 1,  

Migration ⓘ

MMP13↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CRP↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 3,   NF-kB↓, 1,   NF-kB↑, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 1,   eff↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

BMD↑, 1,   CRP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   hepatoP↑, 2,   neuroP↑, 3,   radioP↑, 1,   toxicity∅, 1,  
Total Targets: 47

Scientific Paper Hit Count for: STAT3, Signal transducer and activator of transcription 3
21 Curcumin
15 Thymoquinone
13 Quercetin
12 Apigenin (mainly Parsley)
10 Resveratrol
9 Baicalein
9 Capsaicin
8 Ashwagandha(Withaferin A)
8 EGCG (Epigallocatechin Gallate)
8 Betulinic acid
8 Honokiol
8 Silymarin (Milk Thistle) silibinin
7 Chrysin
6 Berberine
6 brusatol
6 Luteolin
6 Lycopene
5 Artemisinin
5 Caffeic acid
5 Garcinol
5 Pterostilbene
4 Berbamine
4 Sorafenib (brand name Nexavar)
4 Carnosic acid
4 Celastrol
4 Ellagic acid
4 Niclosamide (Niclocide)
4 Piperine
4 Piperlongumine
3 Cisplatin
3 Radiotherapy/Radiation
3 Chemotherapy
3 Boswellia (frankincense)
3 Propolis -bee glue
3 Magnetic Fields
3 Fisetin
3 Sulforaphane (mainly Broccoli)
3 HydroxyTyrosol
3 Oleocanthal
3 Phenethyl isothiocyanate
3 Rosmarinic acid
3 Shikonin
3 Ursolic acid
2 Andrographis
2 Ascorbyl Palmitate
2 Melatonin
2 Arctigenin
2 Baicalin
2 Brucea javanica
2 borneol
2 Boron
2 Emodin
2 Gambogic Acid
2 Genistein (soy isoflavone)
2 Ivermectin
2 Metformin
2 Vitamin C (Ascorbic Acid)
2 Sanguinarine
2 Vitamin K2
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Gemcitabine (Gemzar)
1 Astaxanthin
1 Biochanin A
1 Atorvastatin
1 Bufalin/Huachansu
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carvacrol
1 Cinnamon
1 Oxygen, Hyperbaric
1 methylseleninic acid
1 Deguelin
1 Ferulic acid
1 Gallic acid
1 immunotherapy
1 Paclitaxel
1 Ginkgo biloba
1 Indole-3-carbinol
1 lambertianic acid
1 Magnolol
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Shiitake, AHCC
1 Naringin
1 Oleuropein
1 Orlistat
1 Plumbagin
1 VitK3,menadione
1 Parthenolide
1 salinomycin
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:373  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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