Ca+2 Cancer Research Results

Ca+2, Calcium Ion Ca+2: Click to Expand ⟱
Source:
Type:
In all eukaryotic cells, intracellular Ca2+ levels are maintained at low resting concentrations (approximately 100 nM) by the activity of the major Ca2+ extrusion system, the plasma membrane Ca2+-ATPase (PMCA), which exchanges extracellular protons (H+) for cytosolic Ca2+.
Indeed, sustained elevation of [Ca2+]C in the form of overload, saturating all Ca2+-dependent effectors, prolonged decrease in [Ca2+]ER, causing ER stress response, and high [Ca2+]M, inducing mitochondrial permeability transition (MPT), are considered to be pro-death factors.
In cancer the Ca2+-handling toolkit undergoes profound remodelling (figure 1) to favour activation of Ca2+-dependent transcription factors, such as the nuclear factor of activated T cells (NFAT), c-Myc, c-Jun, c-Fos that promote hypertrophic growth via induction of the expression of the G1 and G1/S phase transition cyclins (D and E) and associated cyclin-dependent kinases (CDK4 and CDK2).
Thus, cancer cells may evade apoptosis through decreasing calcium influx into the cytoplasm. This can be achieved by either downregulation of the expression of plasma membrane Ca2+-permeable ion channels or by reducing the effectiveness of the signalling pathways that activate these channels. Such protective measures would largely diminish the possibility of Ca2+ overload in response to pro-apoptotic stimuli, thereby impairing the effectiveness of mitochondrial and cytoplasmic apoptotic pathways.
Voltage-Gated Calcium Channels (VGCCs): Overexpression of VGCCs has been associated with increased tumor growth and metastasis in various cancers, including breast and prostate cancer.
Store-Operated Calcium Entry (SOCE): SOCE mechanisms, such as STIM1 and ORAI1, are often upregulated in cancer cells, contributing to enhanced cell survival and proliferation.
High intracellular calcium levels are associated with increased cell proliferation and migration, leading to a poorer prognosis. Calcium signaling can also influence hormone receptor status, affecting treatment responses.
Increased Ca²⁺ signaling is associated with advanced disease and metastasis. Patients with higher CaSR expression may have a worse prognosis due to enhanced tumor growth and resistance to apoptosis. -Ca2+ is an important regulator of the electric charge distribution of bio-membranes.
Scientific Papers found: Click to Expand⟱
6809- RF,    Treatment of glioblastoma with tumor-specific amplitude-modulated radiofrequency electromagnetic fields
- in-vitro, GBM, U251
TumCP↓, Dose↝, eff↑, other↝, Dose↝, Dose↝, other↝, VGCC↑, Ca+2↑,
6807- RF,    Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx
- NA, HCC, NA
TumVol↓, Ca+2↑, TumCG↓, Dose↝,
4357- RF,    Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies
- Review, Var, NA
other↝, Dose↝, AntiTum↑, Ca+2↝, eff↝,
3616- RosA,    Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
- Review, AD, NA
*Inflam↓, *memory↑, *toxicity↓, *ROS↓, *Catalase↑, *SOD↑, *NRF2↑, *Aβ↓, *AChE↓, *Ca+2↓, *NO↓, *IL2↓, *COX2/PTGS2↓, *PGE2↓, *MMPs↓, *TNF-α↓, *iNOS↓, *TLR4↓, *cognitive↑, *cortisol↓, *lipid-P↓,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27/CDKN1B↑, CHOP/DDIT3↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
4996- Sal,    The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
CSCs↓, selectivity↑, Wnt↓, ERStress↑, Ca+2↓, UPR↑, CHOP/DDIT3↑, β-catenin/ZEB1↓, CD44↓, CD24↓, PKCδ↑,
5126- Sal,    Salinomycin induces calpain and cytochrome c-mediated neuronal cell death
CSCs↓, Ca+2↑, cal2↑, Casp12↑, Casp9↑, Casp3↑, Cyt‑c↑, MMP↓,
5125- Sal,    Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
- in-vitro, GBM, NA
ER Stress↑, UPR↑, autoF↓, lysosome↝, ROS↑, lipid-P↑, CSCs↓, necrosis↑, ATP↓, MMP↓, MOMP↑, DNAdam↑, AIF↑, lysoMP↑, MitoP↑, Ca+2↑,
2549- SDT,    Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
- Review, Var, NA
sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp/ABCB1↓, ER Stress↑, other↑,
2550- SDT,    Intracellular Delivery and Calcium Transients Generated in Sonoporation Facilitated by Microbubbles
- in-vitro, Nor, NA
*Ca+2↑, sonoP↑, BioEnh↑,
4501- SeNPs,    Mechanisms of the Cytotoxic Effect of Selenium Nanoparticles in Different Human Cancer Cell Lines
- in-vitro, GBM, A172 - in-vitro, Colon, Caco-2 - in-vitro, Pca, DU145 - in-vitro, BC, MCF7 - in-vitro, Nor, L929
*BioAv↑, selectivity↑, AntiCan↑, Apoptosis↑, CHOP/DDIT3↑, GADD34↑, BIM↑, PUMA↑, Ca+2↝,
3658- SFN,    Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
- Review, AD, NA
*NRF2↑, *antiOx↑, *neuroP↑, *Aβ↓, *BACE/β-secretase↓, *NQO1↑, *IL1β↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓, *Ca+2↓, *GSH↑, *MDA↓, *ROS↓, *SOD↑, *HO-1↑, *TrxR↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑,
1735- SFN,    Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane
- in-vitro, GBM, T98G - in-vitro, GBM, U87MG
Apoptosis↑, Ca+2↑, Bax:Bcl2↑, cal2↑, Casp12↑, Casp9↑, Cyt‑c↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
2231- SK,    Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways
- in-vitro, CRC, SNU-407
Apoptosis↑, ER Stress↑, PERK↑, eIF2α↑, CHOP/DDIT3↑, mt-Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, ERK↑, JNK↑, p38↓,
2197- SK,    Shikonin derivatives for cancer prevention and therapy
- Review, Var, NA
ROS↑, Ca+2↑, BAX↑, Bcl-2↓, MMP9↓, NF-kB↓, PKM2↓, Hif1a↓, NRF2↓, P53↑, DNMT1↓, MDR1↓, COX2/PTGS2↓, VEGF↓, EMT↓, MMP7↓, MMP13↓, uPA↓, RIP1↑, RIP3↑, Casp3↑, Casp7↑, Casp9↑, P21↓, DFF45↓, TRAIL↑, PTEN↑, mTOR↓, AR↓, FAK↓, Src↓, Myc↓, RadioS↑,
2188- SK,    Molecular mechanism of shikonin inhibiting tumor growth and potential application in cancer treatment
- Review, Var, NA
ROS↑, EGFR↓, PI3K↓, Akt↓, angioG↓, Apoptosis↑, Necroptosis↑, GSH↓, Ca+2↓, MMP↓, ERK↓, p38↑, proCasp3↑, eff↓, VEGF↓, FOXO3↑, EGR1↑, SIRT1↑, RIP1↑, RIP3↑, BioAv↓, NF-kB↓, Half-Life↓,
3045- SK,    Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2)
- in-vitro, PC, MIA PaCa-2
ECAR↓, Glycolysis↓, ATP↓, PKM2↓, TumCMig↓, Ca+2↑, GlucoseCon↓, lactateProd↓, MMP↓, ROS↑,
2007- SK,    Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
- in-vitro, lymphoma, U937 - in-vitro, BC, MCF7 - in-vitro, BC, SkBr3 - in-vitro, CRC, HCT116 - in-vitro, OS, U2OS - NA, Nor, RPE-1
tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,
3958- Taur,    Evaluation of the neuroprotective effect of taurine in Alzheimer’s disease using functional molecular imaging
- in-vivo, AD, NA
*neuroP↑, *Aβ∅, *cognitive↑, *toxicity↓, *Ca+2↓, *memory↑,
3957- Taur,    Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases
*UPR↑, *Inflam↓, *antiOx↑, *ROS↓, *Apoptosis↓, *Ca+2↓, *neuroP↑,
3955- Taur,    Mechanism of neuroprotective function of taurine
- in-vitro, NA, NA
*Ca+2↓, *MMP↑, *Apoptosis↓, *Bcl-2↑, *cal2↓, *LDH↓,
3950- Taur,    Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes
- Review, Diabetic, NA - Review, Stroke, NA - Review, AD, NA
*Ca+2↝, *neuroP↑, *other↝, *pH↝, *ROS∅, eff↑, *MMP↑, *Apoptosis↓, *other↝, *ER Stress↓, *Bcl-xL↓, *BAX↑, *Cyt‑c↑, *cal2↓, *Casp3↓, *UPR↓, *other↝, *NF-kB↓, *NRF2↑, *GLUT1↑, *GLUT3↑, *memory↑,
3952- Taur,    Taurine and Astrocytes: A Homeostatic and Neuroprotective Relationship
- Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Ca+2↓, *neuroP↑, *other↑, *Dose↝, *PKCδ↓, *VGCC↓, *GABA↑,
3953- Taur,    Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons
- in-vitro, AD, NA
*neuroP↑, *Ca+2↓, *LDH↓,
3956- Taur,    Mechanisms underlying taurine protection against glutamate-induced neurotoxicity
- Review, AD, NA
*MMP↑, *Ca+2↓, *cal2↓, *Bcl-2↑,
3954- Taur,    Mode of action of taurine as a neuroprotector
- in-vitro, AD, NA
*MMP↑, *Ca+2↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
4865- Uro,    Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis
- in-vitro, Diabetic, NA - in-vitro, AD, NA
*antiOx↑, *neuroP↑, *Ca+2↓, *Aβ↓, *BACE/β-secretase↓, *p‑tau↓, *cognitive↑,
1751- WBV,    Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration
- in-vitro, BC, MDA-MB-231 - in-vitro, AML, RAW264.7
BMD↑, YAP/TEAD↑, TumCG↓, Strength↑, TumCI↓, Fas↑, Ca+2↑,
2427- Wog,    Anti-cancer natural products isolated from chinese medicinal herbs
- Review, Var, NA
NO↓, PGE2↓, COX2/PTGS2↓, Ca+2↑, mtDam↑, *toxicity↓, eff↑, eff↓,

Showing Research Papers: 251 to 281 of 281
Prev Page 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 281

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   H2O2↑, 1,   lipid-P↑, 2,   NRF2↓, 1,   ROS↓, 1,   ROS↑, 7,   i-ROS↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 4,   MMP↓, 10,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   PKM2↓, 2,   SIRT1↓, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 6,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   BIM↑, 1,   Casp↑, 1,   Casp12↑, 2,   Casp3↑, 4,   proCasp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 6,   Cyt‑c↑, 5,   Fas↑, 1,   GADD34↑, 1,   JNK↑, 1,   lysoMP↑, 1,   MOMP↑, 1,   Myc↓, 2,   Necroptosis↑, 1,   necrosis↑, 2,   p27/CDKN1B↑, 2,   p38↓, 1,   p38↑, 1,   PUMA↑, 1,   RIP1↑, 2,   survivin↓, 1,   Telomerase↓, 1,   TRAIL↑, 1,   YAP/TEAD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HATs↑, 1,   other↑, 2,   other↝, 3,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 1,   ER Stress↑, 3,   ERStress↑, 1,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

autoF↓, 1,   lysosome↝, 1,   MitoP↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↓, 1,   DNAdam↑, 5,   DNMT1↓, 1,   P53↑, 1,   p‑P53↑, 1,   cl‑PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↓, 1,   P21↑, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD24↓, 1,   CD44↓, 2,   CSCs↓, 4,   EMT↓, 2,   ERK↓, 3,   ERK↑, 1,   FOXO3↑, 1,   Gli1↓, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   IGFBP3↑, 1,   mTOR↓, 2,   NOTCH↓, 1,   PI3K↓, 1,   PTCH1↓, 1,   PTEN↑, 1,   Smo↓, 1,   Src↓, 1,   STAT3↓, 1,   TumCG↓, 4,   VGCC↑, 1,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

CA↓, 1,   Ca+2↓, 2,   Ca+2↑, 15,   Ca+2↝, 2,   mt-Ca+2↑, 1,   cal2↑, 2,   E-cadherin↑, 1,   FAK↓, 2,   GLI2↓, 1,   miR-203↑, 1,   MMP13↓, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 3,   PDGF↓, 1,   PKCδ↓, 1,   PKCδ↑, 1,   RIP3↑, 2,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 2,   TumCMig↓, 4,   TumCP↓, 3,   TumMeta↓, 1,   uPA↓, 2,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   EGFR↓, 2,   EGR1↑, 1,   Hif1a↓, 3,   NO↓, 1,   VEGF↓, 5,  

Barriers & Transport(tgid=15) ⓘ

NHE1↓, 1,   P-gp/ABCB1↓, 1,   sonoP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   IL1↓, 1,   NF-kB↓, 4,   PD-L1↓, 1,   PGE2↓, 2,   PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioEnh↑, 1,   ChemoSen↑, 2,   Dose↝, 8,   eff↓, 2,   eff↑, 5,   eff↝, 3,   Half-Life↓, 2,   Half-Life↝, 2,   MDR1↓, 1,   RadioS↑, 1,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 3,   BMD↑, 1,   EGFR↓, 2,   Myc↓, 2,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 2,   hepatoP↑, 2,   radioP↑, 1,   RenoP↑, 1,   Strength↑, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 1,  
Total Targets: 175

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 2,   GSTs↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 2,   NADH↓, 1,   NQO1↑, 1,   NRF2↑, 3,   RNS↓, 1,   ROS↓, 4,   ROS∅, 1,   SOD↑, 4,   TrxR↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDH↓, 2,   LDL↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↑, 1,   Bcl-2↑, 2,   Bcl-xL↓, 1,   Casp3↓, 1,   Cyt‑c↑, 1,   iNOS↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 2,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,   UPR↓, 1,   UPR↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

VGCC↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↓, 10,   Ca+2↑, 1,   Ca+2↝, 1,   cal2↓, 3,   MMPs↓, 1,   PKCδ↓, 1,   TIMP1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   GLUT1↑, 1,   GLUT3↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 3,   IL1β↓, 1,   IL2↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 5,   NF-kB↓, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   GABA↑, 1,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   Aβ∅, 1,   BACE/β-secretase↓, 2,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   BioAv↝, 1,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   IL6↓, 1,   LDH↓, 2,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↑, 5,   memory↑, 3,   neuroP↑, 7,   Obesity↓, 1,   toxicity↓, 4,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 89

Scientific Paper Hit Count for: Ca+2, Calcium Ion Ca+2
48 Magnetic Fields
17 Capsaicin
10 Electrical Pulses
9 Baicalein
9 Boron
9 Quercetin
8 Citric Acid
8 EGCG (Epigallocatechin Gallate)
8 Taurine
7 Apigenin (mainly Parsley)
7 Magnetic Field Rotating
6 Berberine
6 Chrysin
6 Fisetin
6 Honokiol
5 Silver-NanoParticles
5 Resveratrol
5 Shikonin
4 Allicin (mainly Garlic)
4 Propolis -bee glue
4 Gallic acid
4 salinomycin
3 Betulinic acid
3 Curcumin
3 Eugenol
3 Isobavachalcone
3 Magnolol
3 Phenethyl isothiocyanate
2 Artemisinin
2 Chemotherapy
2 Boswellia (frankincense)
2 Caffeic acid
2 Carvacrol
2 Cannabidiol
2 Chlorogenic acid
2 immunotherapy
2 Dichloroacetate
2 Emodin
2 Ferulic acid
2 Hydrogen Gas
2 Juglone
2 Luteolin
2 Lycopene
2 Melatonin
2 doxorubicin
2 EMF
2 SonoDynamic Therapy UltraSound
2 Sulforaphane (mainly Broccoli)
1 5-Aminolevulinic acid
1 Photodynamic Therapy
1 Anthocyanins
1 Resiquimod
1 Alpha-Lipoic-Acid
1 Aloe anthraquinones
1 Baicalin
1 Berbamine
1 Bacopa monnieri
1 Celecoxib
1 Chocolate
1 Choline
1 Cinnamon
1 Crocetin
1 Copper and Cu NanoParticles
1 Cynaropicrin
1 Diclofenac
1 Dimethyl Sulfoxide
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Evodiamine
1 Folic Acid, Vit B9
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Hibiscus sabdariffa
1 Helleborus niger extracts – Christmas Rose
1 Hyperthermia
1 Isoliquiritigenin
1 isoquercitrin
1 Isovitexin
1 Vitexin
1 magnetic nanoparticles
1 Iron
1 Caffeine
1 Radiotherapy/Radiation
1 Moringa oleifera
1 Mushroom Lion’s Mane
1 Nimbolide
1 Phenylbutyrate
1 temozolomide
1 Piperlongumine
1 Plumbagin
1 Parthenolide
1 Pterostilbene
1 Kaempferol
1 Radio Frequency
1 Rosmarinic acid
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Thymol-Thymus vulgaris
1 Urolithin
1 Whole Body Vibration
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:38  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page