GPx Cancer Research Results

GPx, Glutathione peroxidases: Click to Expand ⟱

Source:

Type:

Glutathione peroxidases (GPXs) are crucial antioxidant enzymes, counteracting reactive oxygen species (ROS).
Glutathione peroxidase (GPx) refers to a family of antioxidant enzymes that play a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides. There are several isoforms of GPx, including GPx1, GPx2, GPx3, and GPx4, each with distinct tissue distributions and functions.
GPX overexpression promotes proliferation and invasion in cancer cells. Glutathione peroxidase-1 (GPX1), the most abundant isoform, contributes to invasion, migration, cisplatin resistance, and proliferation in various cancers.

GPx expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in protecting cancer cells from oxidative stress and contributing to treatment resistance.

Scientific Papers found: Click to Expand⟱

1741-

VitD3,

Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging

-

Review,

Var,

NA

*Inflam↓, *antiOx↑, *eff↑, *ROS↓, *NRF2↑, *GPx↑, *Dose↝, Dose↑,

7887-

VT,

IVT,

Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention

-

Review,

AD,

NA

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,

Showing Research Papers: 251 to 252 of 252
Prev Page 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 252

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1, antiOx↑, 9, Catalase↓, 12, Catalase↑, 13, GPx↓, 20, GPx↑, 28, GPx4↓, 3, GSH↓, 20, GSH↑, 9, GSH⇅, 1, GSH/GSSG↓, 2, GSR↓, 3, GSR↑, 4, GSTs↓, 1, GSTs↑, 1, H2O2↓, 1, H2O2↑, 4, HO-1↓, 2, HO-1↑, 8, Iron↑, 4, Iron↝, 1, lipid-P↓, 5, lipid-P↑, 11, MDA?, 1, MDA↓, 5, MDA↑, 6, MPO↓, 2, NADPH/NADP+↓, 1, NFE2L2↑, 1, NQO1↓, 2, NQO1↑, 1, NRF2↓, 6, NRF2↑, 12, ROS↓, 15, ROS↑, 71, ROS⇅, 1, ROS↝, 1, i-ROS↑, 1, mt-ROS↑, 1, selenoP↑, 1, SOD↓, 12, SOD↑, 15, SOD1↑, 1, SOD2↓, 2, SOD2↑, 1, TAC↓, 1, Thiols↓, 1, Trx↓, 1, Trx1↓, 1, TrxR↑, 1, VitC↓, 1, VitE↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1, FTH1↑, 1, FTL↑, 1, IronCh↑, 2, NCOA4↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↑, 1, CDC25↓, 4, compI↓, 1, compIII↓, 1, compIV↓, 1, MFN2↑, 1, mitResp↓, 1, MKK7↓, 1, mtDam↑, 10, OCR↑, 1, OXPHOS↓, 1, OXPHOS↑, 3, PGC-1α↑, 1, SDH↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3, AMPK↑, 2, ATP↓, 6, ATP↑, 1, mt-ATP↓, 1, CAIX/CA9↑, 1, citrate↓, 1, FAO↑, 1, FASN↓, 1, G6PD↓, 1, GAPDH↓, 1, glucose↓, 1, GlucoseCon↓, 3, Glycolysis↓, 14, GSK‐3β↓, 3, GSK‐3β↑, 2, p‑GSK‐3β↓, 3, HK2↓, 6, lactateProd↓, 5, LDHA↓, 3, LDL↓, 1, MCT4↓, 1, NAD↓, 1, NADPH↓, 2, NADPH↑, 3, PDK1 / PDPK1↓, 2, PDK3↑, 1, PFKP↓, 1, PKM2↓, 3, Pyruv↓, 2, RNR↓, 1, SCD1↓, 1, SIRT1↓, 4, SIRT1↑, 4, TCA↓, 1, TCA↑, 1, Warburg↓, 5,

Cell Death(tgid=5) ⓘ

AIF↑, 4, APAF1↑, 2, Apoptosis↓, 2, Apoptosis↑, 49, ASC↓, 1, BAD↓, 1, BAD↑, 1, BAX↓, 2, BAX↑, 35, Bax:Bcl2↑, 2, Bcl-2↓, 29, Bcl-2↑, 5, Bcl-xL↓, 5, Bcl-xL↑, 1, BID↑, 1, BIM↑, 1, Casp↑, 7, Casp↝, 1, Casp1↓, 1, Casp1↑, 1, Casp3↓, 1, Casp3↑, 39, cl‑Casp3↑, 3, cl‑Casp3⇅, 1, cl‑Casp3∅, 1, Casp6↑, 1, Casp7↑, 8, cl‑Casp7↑, 1, Casp8↑, 12, Casp9↑, 27, cl‑Casp9↑, 1, Cyt‑c↑, 18, mt-Cyt‑c↓, 1, Diablo↑, 1, DR5↑, 5, FADD↑, 1, Fas↑, 7, FasL↑, 2, Ferroptosis↓, 1, Ferroptosis↑, 6, IAP1↓, 2, IAP2/BIRC3↓, 1, iNOS↓, 5, Mcl-1↓, 1, MDM2↓, 1, p‑MDM2↓, 1, Necroptosis↑, 1, NOXA↑, 1, p38↓, 1, p38↑, 7, p‑p38↑, 1, PUMA↑, 2, survivin↓, 8, TumCD↑, 5, XIAP↓, 3,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 33, Akt↑, 2, p‑Akt↓, 9, AMPKα↑, 1, CaMKII ↓, 1, CK2↓, 1, cSrc↓, 1, EGFR↓, 6, EGFR↑, 1, ERK↓, 13, ERK↑, 1, p‑ERK↓, 1, FGFR1↓, 2, FGFR2↓, 1, HER2/EBBR2↓, 2, HGF/c-Met↓, 2, HRAS↓, 1, IGF-1R↓, 3, IKKα↓, 1, JAK↓, 1, JAK1↓, 1, JAK2↓, 1, JNK↑, 6, p‑JNK↓, 1, p‑JNK↑, 2, MAP2K1/MEK1↓, 1, MAPK↓, 5, MAPK↑, 6, MAPK↝, 1, MARK4↓, 1, p‑MEK↓, 1, MKK4↓, 1, mTOR↓, 17, mTOR↝, 1, p‑mTOR↓, 3, P70S6K↓, 1, p‑P70S6K↓, 1, PI3K↓, 25, PI3K↑, 1, p‑PI3K↓, 3, p‑PI3K↑, 1, PI3K/Akt↓, 1, PKCδ↓, 1, PTEN↓, 1, PTEN↑, 8, Raf↓, 2, RAS↓, 2, Sp1/3/4↓, 2, p‑Src↓, 1, STAT↓, 1, STAT3↓, 16, p‑STAT3↓, 3, p‑STAT6↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 2, ATFs↑, 1, cJun↓, 1, cMyc↓, 8, cMyc↑, 1, DNMT1↓, 1, EZH2↓, 2, FOXO1↓, 1, FOXO1↑, 1, FOXO3↓, 2, FOXO3↑, 2, FOXO3↝, 1, FOXO4↓, 1, H3↓, 1, H4↓, 1, HDAC↓, 3, HDAC1↓, 3, HDAC2↓, 2, HDAC3↓, 2, miR-124-3p↓, 1, miR-155↓, 1, miR-25-5p↓, 1, miR-34a↓, 1, miR-34a↑, 1, OCT4↓, 2, other?, 1, other↓, 2, other↑, 1, other↝, 1, PAX2↓, 1, SOX2↓, 1, tumCV↓, 14, USF1↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4, eIF2α↑, 1, p‑eIF2α↑, 1, ER Stress↑, 9, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 1, HSP90↓, 2, NQO2↑, 1, PERK↑, 1, UPR↑, 2,

Autophagy & Lysosomes(tgid=9) ⓘ

autolysosome↑, 1, Beclin-1/ATG6↓, 2, Beclin-1/ATG6↑, 4, CTSB↓, 1, CTSD↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 2, LC3II↓, 1, LC3II↑, 2, LC3s↑, 1, p62↓, 3, TumAuto↓, 1, TumAuto↑, 6, TumAuto↝, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2, DNAdam↓, 1, DNAdam↑, 17, DNArepair↑, 1, P53↓, 3, P53↑, 28, P53↝, 1, p‑P53↑, 1, PARP↑, 6, cl‑PARP↑, 9, cl‑PARP∅, 1, PCNA↓, 13, Telomerase↓, 1, TOP1↓, 1, γH2AX↓, 1, γH2AX↑, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1, CDK1↓, 2, CDK1↑, 2, CDK2↓, 6, CDK2↑, 1, CDK4↓, 11, CDK6↓, 3, CDK6↑, 1, CHK1↓, 1, Chk2↓, 1, Cyc↓, 2, cycA1/CCNA1↓, 1, CycB/CCNB1↓, 5, CycB/CCNB1↑, 1, cycD1/CCND1↓, 16, cycE/CCNE↓, 4, E2Fs↓, 1, Ki-67↓, 10, mitA↑, 1, P21↓, 2, P21↑, 18, p27/CDKN1B↑, 5, pRB↓, 1, pRB↑, 1, RB1↑, 1, TumCCA↑, 45,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1, CD34↓, 1, cFos↑, 1, CSCs?, 1, CSCs↓, 3, Diff↑, 1, EIF4E↓, 1, FGF↓, 1, Gli1↓, 3, HH↓, 1, IGF-1↓, 2, Ki-67↓, 10, mTORC1↓, 1, Nanog↓, 1, NOTCH↓, 1, NOTCH1↓, 4, NOTCH1↑, 1, Smo↓, 1, STAT1↓, 1, TumCG↓, 17, TumCG↑, 2, TumCP↓, 34, TumCP↑, 1, tyrosinase↓, 1, Wnt↓, 4,

Migration(tgid=13) ⓘ

AP-1↓, 2, AXL↓, 2, BACH1↓, 1, BACH1↑, 1, Ca+2↓, 1, Ca+2↑, 2, i-Ca+2↑, 2, CD11b↑, 1, Cdc42↓, 1, E-cadherin↓, 6, E-cadherin↑, 8, EMT↓, 12, EMT↑, 2, EMT↝, 1, EpCAM↓, 1, F-actin↓, 1, FAK↓, 2, p‑FAK↓, 1, ITGB1↓, 1, KRAS↓, 1, LAMs↓, 1, MALAT1↓, 1, MET↓, 1, p‑MET↓, 1, MMP1↓, 1, MMP13↓, 2, MMP2↓, 19, MMP3↓, 2, MMP7↓, 2, MMP9↓, 22, MMP9↑, 2, MMPs↓, 5, N-cadherin↓, 9, PDGF↓, 1, Rac1↓, 1, RECK↑, 1, Rho↓, 3, ROCK1↓, 2, Slug?, 1, Slug↓, 1, Smad1↓, 1, Snail?, 1, Snail↓, 1, TET1↑, 1, TGF-β↓, 2, TIMP1↑, 4, TIMP2↓, 1, TIMP2↑, 3, TIMP3↑, 1, TRIB3↑, 1, TumCI↓, 17, TumCMig↓, 18, TumMeta↓, 17, TumMeta↑, 3, Twist↓, 2, Tyro3↓, 1, uPA↓, 2, uPAR↓, 1, Vim↓, 9, Vim↑, 1, Zeb1↓, 1, ZEB2↓, 1, β-catenin/ZEB1↓, 8,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 20, angioG↑, 1, CD31/PECAM-1↓, 2, HIF-1↓, 2, Hif1a↓, 18, NO↓, 2, NO↑, 2, REL↑, 1, VCAM-1↓, 1, VEGF↓, 23, VEGFR1↓, 2, VEGFR2/KDR/Flk1↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1, CLDN1↓, 1, GLUT1↓, 4, GLUT1↑, 1, GLUT3↑, 1, GLUT4↓, 1, MMP↓, 18, MMP↑, 2, TRPM7↓, 1, TRPV1↓, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1, CD4+↓, 1, CD4+↑, 1, CD44↓, 2, CD47↓, 1, CD8+↑, 2, COX2/PTGS2↓, 24, COX2/PTGS2↑, 1, CXCc↓, 1, CXCR3↓, 1, CXCR4↓, 3, DR4↑, 2, FOXP3↓, 1, FOXP3↑, 1, HMGB1↓, 2, ICAM-1↓, 3, IFN-γ↓, 2, IL1↓, 2, IL1↑, 1, IL10↑, 2, IL1β↓, 3, IL2↓, 1, IL2↑, 3, IL4↓, 1, IL4↑, 2, IL6↓, 15, IL8↓, 2, Imm↑, 5, Inflam↓, 8, Inflam↑, 1, MCP1/CCL2↓, 1, NF-kB↓, 32, NF-kB↑, 1, p‑NF-kB↑, 1, NK cell↑, 5, NLRP3↓, 2, p65↓, 1, p‑p65↓, 1, PD-1↓, 2, PD-L1↓, 2, PGE2↓, 5, PSA↓, 2, PSA∅, 1, T-Cell↑, 1, Th1 response↑, 1, TLR4↓, 1, TNF-α↓, 14, TNF-α↑, 2, Treg lymp↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6, ER-α36↓, 1, Estro↝, 1, GR↑, 1, PPARγ↓, 1, PPARγ↑, 2, PPARγ↝, 1, RANKL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10, BioAv↑, 6, BioAv↝, 4, BioEnh?, 1, ChemoSen↑, 43, CompStab↓, 1, CompStab↝, 1, CYP1A1↓, 1, Dose↑, 5, Dose↝, 15, Dose∅, 2, eff↓, 9, eff↑, 25, eff↝, 1, eff∅, 1, GSTA1↑, 1, Half-Life↓, 1, MRP1/ABCC1↓, 1, P-gp/ABCB1↓, 3, P450↓, 1, RadioS↑, 13, selectivity↑, 23, Synergy↑, 31,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2, ALAT↓, 3, ALP↓, 1, AR↓, 6, AST↓, 2, BP↓, 1, CEA↓, 1, E6↓, 1, E7↓, 1, EGFR↓, 6, EGFR↑, 1, EZH2↓, 2, HER2/EBBR2↓, 2, IL6↓, 15, KRAS↓, 1, LDH↓, 2, LDH↝, 1, NSE↓, 1, PD-L1↓, 2, PSA↓, 2, PSA∅, 1, TG/TAG↓, 1, TRIB3↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, AntiCan↓, 1, AntiCan↑, 20, antiNeop↑, 1, AntiTum↑, 6, Appetite↑, 1, cachexia↓, 2, cardioP↑, 4, chemoP↑, 17, chemoPv↑, 3, ChemoSideEff↓, 1, cognitive↑, 2, fatigue↓, 1, hepatoP↑, 7, Mucositis↓, 1, neuroP↑, 4, NP/CIPN↓, 2, OS↑, 8, Pain↓, 2, PFS↑, 1, Pin1↓, 1, QoL↑, 4, radioP↑, 10, RenoP↑, 2, Risk↓, 9, Sleep↑, 2, toxicity↓, 3, toxicity↝, 1, TumVol↓, 6, TumW↓, 1, Weight↑, 2,

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 565

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 3, antiOx?, 1, antiOx↓, 4, antiOx↑, 102, ARE↑, 2, Bil↓, 2, Catalase↓, 4, Catalase↑, 123, Catalase↝, 1, Copper↓, 2, Fenton↓, 2, GCLC↑, 1, GCLM↑, 1, GPx↓, 6, GPx↑, 202, GPx↝, 1, GPx∅, 1, GPx4↓, 1, GPx4↑, 2, GSH↓, 2, GSH↑, 89, GSH∅, 1, GSH/GSSG↓, 1, GSH/GSSG↑, 1, GSR↓, 2, GSR↑, 25, GSSG↓, 3, GSTs↓, 2, GSTs↑, 24, H2O2↓, 9, HDL↓, 1, HDL↑, 5, HO-1↓, 3, HO-1↑, 51, HO-1⇅, 1, Iron↓, 5, i-Iron↓, 1, i-Iron↑, 1, Keap1↓, 8, Keap1↝, 1, lipid-P↓, 62, MDA↓, 84, MDA↑, 3, MPO↓, 6, NADH↓, 1, NOX↓, 1, NQO1↑, 11, NRF2↓, 1, NRF2↑, 82, Prx↓, 1, Prx↑, 2, RNS↓, 1, ROS?, 2, ROS↓, 164, ROS↑, 4, ROS⇅, 1, ROS∅, 2, mt-ROS?, 1, mt-ROS↓, 2, SAM-e↑, 1, selenoP↑, 5, SOD?, 1, SOD↓, 2, SOD↑, 160, SOD↝, 1, SOD1↑, 4, SOD2↑, 6, TAC↑, 15, TBARS↓, 3, TBARS↑, 1, Thiols↑, 2, Trx↑, 3, Trx1↑, 1, TrxR↓, 1, TrxR↑, 1, uricA↓, 1, VitC↑, 7, VitE↑, 5,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1, Ferritin↑, 1, FPN↑, 1, FTL↓, 1, IronCh↑, 4, TfR1/CD71↓, 1, TfR1/CD71↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1, compIII↑, 1, DRP1/DNM1L↓, 2, EGF↓, 1, ETC↑, 1, Insulin↓, 1, Insulin↑, 2, MFN1↑, 1, MFN2↑, 2, mtDam↓, 2, OCR↑, 1, OPA1↑, 1, OXPHOS↑, 1, PGC-1α↑, 3, PGC-1α↝, 1, SIRT3↑, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 5LO↓, 3, mt-ACC⇅, 1, ACSL4↓, 1, adiP↓, 1, ALAT↓, 25, ALAT↑, 1, AMPK↓, 1, AMPK↑, 6, ATP↓, 1, ATP↑, 11, ATP↝, 1, Buty↑, 1, cAMP↑, 1, DGAT1↓, 1, FAO↑, 1, FASN↓, 1, G6PD↑, 1, glucose↓, 7, glucose↝, 1, GlucoseCon↓, 1, GlucoseCon↑, 3, GlutMet↑, 1, Glycolysis↝, 2, GSK‐3β↓, 10, GSK‐3β↑, 2, p‑GSK‐3β↑, 2, HK2↓, 1, HMG-CoA↓, 2, lactateProd↓, 1, LDHA↓, 1, LDL↓, 13, NAD↓, 1, NAD↑, 1, NAD↝, 1, NADPH↓, 2, NADPH↑, 4, PDKs↑, 1, PFK↓, 1, PFK2↓, 1, PGC1A↑, 1, PKM1↑, 1, PKM2↓, 1, PKM2↑, 1, PONs↑, 1, PPP↓, 1, SCFAs↑, 2, SIRT1↑, 14, SREBP1/SREBF1↓, 1,

Cell Death(tgid=5) ⓘ

AIF↓, 2, Apoptosis↓, 18, BAD↓, 1, BAX↓, 15, BAX↑, 1, Bax:Bcl2↓, 1, Bcl-2↓, 3, Bcl-2↑, 11, Bcl-2↝, 1, Casp↓, 1, Casp12↓, 1, Casp3↓, 26, cl‑Casp3↓, 2, proCasp3↑, 1, Casp8↓, 1, Casp9↓, 11, Cyt‑c↓, 3, Fas↓, 1, Ferroptosis↓, 3, GranB/GZMB↓, 1, iNOS↓, 19, iNOS↑, 1, necrosis↓, 1, p38↓, 2, survivin↓, 1, TUNEL↓, 1, YAP/TEAD↑, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6, Akt↑, 5, p‑Akt↓, 1, p‑Akt↑, 4, CREB↑, 5, p‑CREB↑, 3, ERK↓, 1, ERK↑, 4, p‑ERK↑, 2, HGF/c-Met↑, 1, Hippo↑, 1, IKKα↓, 2, IκB?, 1, JAK2↓, 1, JNK↓, 7, JNK↑, 1, p‑JNK↓, 1, MAPK↓, 11, MAPK↑, 1, MAPK↝, 1, mTOR↓, 3, mTOR↑, 1, p‑mTOR↓, 2, p‑mTOR↑, 1, PI3K↓, 3, PI3K↑, 4, PI3K↝, 1, p‑PI3K↓, 1, PKA↑, 1, PKCδ?, 1, PP2A↑, 1, PTEN↓, 1, RAS↓, 1, STAT↓, 1, STAT3↓, 3, STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1, ATF4↓, 2, cJun↓, 1, cMyc↓, 1, FOXO3↑, 2, HDAC?, 1, HDAC↓, 1, miR-34a↓, 1, other?, 1, other↓, 7, other↑, 12, other↝, 3, RUNX2↑, 1, SOX2↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 6, CHOP/DDIT3↑, 1, p‑eIF2α↓, 1, ER Stress↓, 6, GRP78/BiP↓, 6, GRP78/BiP↑, 1, GRP94↑, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 2, HSPs↑, 1, XBP-1↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 3, LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3II↓, 1, LC3II↑, 2, MitoP↑, 2, p62↑, 3,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 9, P53↓, 1, P53↑, 1, cl‑PARP↓, 1, PARP1↓, 1, PCNA↓, 1, p‑γH2AX↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1, CDK4↓, 1, cycD1/CCND1↓, 2, cycE/CCNE↓, 1, GADD34↓, 1, Ki-67↑, 1, P21↓, 1, RB1↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, BMPs↑, 1, CHIP↑, 1, Diff↑, 1, HH↓, 1, IGF-1↑, 2, Ki-67↑, 1, Nestin↑, 1, neuroG↑, 3, NOTCH1↑, 1, p300↓, 1, TumCP↓, 1, tyrosinase↓, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 5, AP-1↓, 2, AP-1↑, 1, ATPase↑, 1, Ca+2↓, 8, Ca+2↝, 2, COL1↓, 2, COL1↑, 1, E-cadherin↑, 1, EMT↓, 2, Fibrosis↓, 1, MMP13↓, 1, MMP2↓, 1, MMP3↓, 1, MMP9↓, 6, MMP9↑, 1, MUC1↑, 1, serineP↓, 1, p‑T-cadherin↓, 1, TGF-β↓, 4, TGF-β↑, 1, TGF-β1↓, 2, TGF-β1↑, 1, TumCI↓, 1, TXNIP↓, 1, Vim↓, 3, α-SMA↓, 5, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, E-sel↓, 1, HIF-1↓, 1, Hif1a↓, 2, LOX1↓, 1, NO↓, 22, NO↑, 1, VCAM-1↓, 4, VEGF↓, 3, VEGF↑, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2, BBB↑, 16, GastroP↑, 4, GLUT2↑, 1, GLUT3↑, 1, GLUT4↑, 2, H+/K+-ATPase↓, 1, IBI↑, 3, MMP↓, 1, MMP↑, 10, OCLN↑, 1, TJ↑, 1, TRPA1↑, 1, TRPC1↓, 1, TRPM7↓, 2, TRPM7⇅, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1, CD4+↑, 2, CD40↓, 1, COX1↓, 2, COX2/PTGS2↓, 42, COX2/PTGS2↑, 2, Eos↓, 1, GM-CSF↓, 1, HMGB1↓, 2, ICAM-1↓, 4, IFN-γ↓, 5, IFN-γ↑, 2, IgE↓, 1, IL1↓, 1, IL10↓, 7, IL10↑, 12, IL12↓, 2, IL12↑, 1, IL13↓, 1, IL17↓, 5, IL18↓, 1, IL1β↓, 43, IL2↓, 3, IL2↑, 2, IL23↓, 2, IL4↓, 4, IL4↑, 3, IL5↓, 2, IL6↓, 44, IL6↑, 1, IL8↓, 3, IL8↑, 1, Imm↓, 1, Imm↑, 6, INF-γ↓, 2, Inflam↓, 106, Inflam↑, 1, IP-10/CXCL-10↓, 1, IRF3↓, 1, LPS↓, 2, pol-M2 MC↑, 1, MCP1/CCL2↓, 6, MIP‑1α/CCL3↓, 1, MyD88↓, 3, NeuroI↓, 2, NF-kB↓, 49, NF-kB↑, 1, NK cell↑, 2, NLRP3↓, 8, p65↓, 1, PGE2↓, 14, RAGE↓, 2, RANTES↓, 1, SOCS-3↓, 1, TLR2↓, 1, TLR4↓, 13, TNF-α↓, 60, TNF-α↑, 2, TRAF6↓, 1, TRIF↓, 1, VitD↑, 1,

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 6, Ach↑, 9, AChE↓, 31, ADAM10↑, 1, BChE↓, 4, BDNF↓, 1, BDNF↑, 18, BDNF⇅, 1, ChAT↑, 8, GABA↑, 3, MAOA↓, 3, MAOB↓, 1, monoA↓, 1, monoA↑, 1, NGF↑, 4, PSD95↑, 2, SYP↑, 1, TrkB↑, 3,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4, APP↓, 2, Aβ↓, 27, Aβ42↓, 2, BACE/β-secretase↓, 9, tau↓, 8, p‑tau↓, 8, XO↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1, ACE2↓, 1, AHR↓, 1, BNP↓, 1, CYP19↓, 1, ER(estro)↑, 1, GLP-1R↑, 1, GR↓, 1, GR↑, 5, GR↝, 1, PPARα↝, 1, PPARγ↓, 1, PPARγ↑, 4, testos↑, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 20, BioAv↑, 40, BioAv⇅, 1, BioAv↝, 23, BioEnh↑, 2, ChemoSen↑, 1, CompStab↑, 1, CYP2E1↓, 2, Dose?, 2, Dose↑, 2, Dose⇅, 1, Dose↝, 23, eff↓, 3, eff↑, 16, eff↝, 1, GSTA1↓, 1, GSTA1↑, 3, Half-Life↓, 4, Half-Life↑, 2, Half-Life↝, 7, P450↓, 1, selectivity↑, 2, Synergy↑, 11,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 25, ALAT↑, 1, ALP↓, 12, anemia↓, 1, AST↓, 27, AST↑, 1, BG↓, 3, Bil↓, 2, BloodF↑, 1, BMD↑, 1, BP↓, 5, BP↝, 1, BUN↓, 3, Calcium↑, 1, CEA↓, 2, creat↓, 5, CRP↓, 8, Ferritin↓, 1, Ferritin↑, 1, HemoG↑, 1, hs-CRP↓, 1, IL6↓, 44, IL6↑, 1, IRes↝, 1, LDH↓, 10, LDH↑, 1, Mag↑, 1, NLR↓, 1, NOS2↓, 1, RAGE↓, 2, RBC↑, 1, TC↓, 2, TG/TAG↓, 5, Urea↓, 3, VitD↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3, antiAll↑, 12, AntiArt↑, 4, AntiCan↑, 12, AntiDiabetic↑, 18, antiNeop↑, 1, antiPs↑, 3, AntiTum↑, 1, BOLD↑, 1, cardioP↑, 39, CardioT↓, 1, chemoP↑, 11, chemoPv↑, 2, ChemoSideEff↓, 1, cognitive↓, 2, cognitive↑, 36, diuretic↑, 1, hepatoP↓, 2, hepatoP↑, 44, Learn↑, 2, memory↑, 37, motorD↑, 6, neuroP↑, 82, NP/CIPN↓, 1, Obesity↓, 12, OS↑, 2, Pain↓, 4, radioP↑, 3, RenoP↑, 14, Risk↓, 7, Sleep↑, 2, Strength↑, 1, Stroke↓, 8, toxicity↓, 14, toxicity↝, 8, toxicity∅, 5, Weight↓, 1, Weight↑, 1, Wound Healing↑, 3,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 11, AntiFungal↑, 1, AntiViral↑, 5, Bacteria↓, 10, GutMicro↑, 24, Sepsis↓, 5,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2, Ingr↝, 2,
Total Targets: 535

Scientific Paper Hit Count for: GPx, Glutathione peroxidases

9 Lycopene
9 Thymoquinone
8 Melatonin
8 Quercetin
7 Silver-NanoParticles
7 Carvacrol
7 Resveratrol
7 Selenite (Sodium)
6 Selenium
6 EGCG (Epigallocatechin Gallate)
6 Hydrogen Gas
6 Magnetic Fields
6 Selenium NanoParticles
5 Alpha-Lipoic-Acid
5 Propolis -bee glue
5 Curcumin
5 Urolithin
5 Vitamin C (Ascorbic Acid)
4 Apigenin (mainly Parsley)
4 Ashwagandha(Withaferin A)
4 Boron
4 Chlorogenic acid
4 Chrysin
4 Crocetin
4 Radiotherapy/Radiation
4 Ferulic acid
4 Sulforaphane (mainly Broccoli)
4 Rosmarinic acid
4 Silymarin (Milk Thistle) silibinin
3 Capsaicin
3 Chemotherapy
3 D-limonene
3 Eugenol
3 Gallic acid
3 Hyperoside
3 Isoliquiritigenin
3 L-Theanine
3 Licorice
3 Luteolin
3 Moringa oleifera
3 Morin
2 1,8-Cineole
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Berberine
2 Phenethyl isothiocyanate
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Sesame seeds and Oil
2 doxorubicin
2 isoorientin
2 Kaempferol
2 Matrine
2 Cisplatin
2 Methylsulfonylmethane
2 Pterostilbene
2 chitosan
2 Shikonin
1 3-bromopyruvate
1 Annona atemoya Seed Extract
1 Anthocyanins
1 Photodynamic Therapy
1 Camptothecin
1 Astaxanthin
1 Aloe anthraquinones
1 Baicalein
1 Biochanin A
1 Beta-Caryophyllene
1 Betulinic acid
1 Benzyl isothiocyanate
1 Allyl isothiocyanate
1 Bacopa monnieri
1 Boswellia (frankincense)
1 buckwheat sprouts
1 Cichoric acid / Chicoric acid
1 Citicoline, CDP-Choline
1 Citric Acid
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Date Fruit Extract
1 Emodin
1 erastin
1 Fisetin
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 Gold NanoParticles
1 Zinc
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Isobavachalcone
1 Butein
1 Scopoletin
1 Isothiocyanates
1 Juglone
1 Lactoferrin/Talactoferrin
1 Vitamin E
1 Magnolol
1 Mung Bean Sprouts
1 methylseleninic acid
1 Magnetic Field Rotating
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Piperine
1 Piperlongumine
1 salinomycin
1 polyethylene glycol
1 Sesamin
1 Lignans
1 Safflower yellow
1 5-fluorouracil
1 Ursolic acid
1 VitK3,menadione
1 Vitamin D3
1 Vitexin
1 Isovitexin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:418  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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