Casp9 Cancer Research Results

Casp9, Caspase-9: Click to Expand ⟱
Source:
Type:
Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspase-9:
Role: Initiator caspase in the intrinsic apoptotic pathway.
Cancers: Frequently studied in leukemia and solid tumors.
Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis.
Scientific Papers found: Click to Expand⟱
6917- FIS,    Dietary flavonoid fisetin regulates aluminium chloride-induced neuronal apoptosis in cortex and hippocampus of mice brain
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *Dose↝, *Aβ↓, *ASK1↓, *p‑JNK↓, *P53↓, *Cyt‑c↓, *Casp9↓, *Bax:Bcl2↝,
6918- FIS,  Geld,  Radic,    HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells
- in-vitro, CRC, COLO205
eff↑, cl‑Casp3↑, PARP↑, MMPs↓, cl‑Casp9↑, other↝,
6899- FIS,    Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, 22Rv1
Dose↝, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↑, CDK4↑, CDK6↑, P21↑, p27/CDKN1B↑, Apoptosis↑, cl‑PARP↑, Cyt‑c↑, XIAP↓, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, PI3K↓, Akt↓,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, eff↑, *toxicity↓, *BioAv↑, *BioAv↑, *eff↑,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, eff↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, eff↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6986- Form,    Anti-angiogenesis Function of Ononin via Suppressing the MEK/Erk Signaling Pathway
- in-vitro, NA, NA
other↝, AntiCan↑, VEGF↓, Apoptosis↑, Bax:Bcl2↑, cl‑Casp3↑, cl‑Casp9↑, Cyt‑c↑, Hif1a↓, MEK↓, ERK↓, VEGFR2/KDR/Flk1↓, angioG↓,
6970- Form,    Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells
- in-vitro, Ovarian, NA
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑, Bax:Bcl2↑, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑ERK↓,
7020- Fuc,    Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells
- in-vitro, BC, MCF7 - in-vitro, Cerv, HeLa - in-vitro, Nor, WI38
tumCV↓, selectivity↑, Apoptosis↑, Casp8↑, Casp9↑,
7009- Fuc,    Effects of Fucoidan and Chemotherapeutic Agent Combinations on Malignant and Non-malignant Breast Cell Lines
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF12A
selectivity↑, TumCCA↑, Casp3↑, Casp7↑, Casp9↑, ChemoSen↑, chemoP↑,
7005- Fuc,    Fucoidan and cancer: a multifunctional molecule with anti-tumor potential
- Review, Var, NA
AntiCan↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, MMP↓, Casp9↑, survivin↓, IAP1↓, Cyt‑c↑, Diablo↑, Bak↑, XIAP↓, VEGF↓, angioG↓, MMP2↓, MMP9↓, Akt↓, eff↝, TumMeta↓,
1155- Fuc,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, NA, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
7049- GA,    Pharmacological effects of gallic acid in health and diseases: A mechanistic review
- Review, Var, NA
*antiOx↑, *Inflam↓, *antiNeop↑, *cardioP↑, *Bacteria↓, *AST↓, *ALAT↓, *ALP↓, *lipid-P↓, *GSH↑, *Catalase↑, *GPx↑, *GSTs↑, *Urea↓, *creat↓, tumCV↓, TumCCA↑, i-Ca+2↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, MMP↓, ROS↑, MMPs↓, *GastroP↑, *hepatoP↑, *ROS↓, *AChE↑,
7033- GA,  OL,    Gallic Acid Enhances Olaparib-Induced Cell Death and Attenuates Olaparib Resistance in Human Osteosarcoma U2OS Cell Line
- in-vitro, OS, U2OS
tumCV↓, angioG↓, DNAdam↑, Apoptosis↑, cl‑PARP↓, Bcl-2↓, BAX↑, ROS↓, eff↑, TumCMig↓, VEGF↓, Casp9↑, P53↑, selectivity↑,
7029- GA,    Gallic acid induces G1 phase arrest and apoptosis of triple-negative breast cancer cell MDA-MB-231 via p38 mitogen-activated protein kinase/p21/p27 axis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, Nor, MCF10
AntiTum↑, tumCV↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CDK2↓, P21↑, p27/CDKN1B↑, Casp9↑, Casp3↑, ROS↑, mtDam↑, i-Ca+2↑, *ROS↓, *Apoptosis↓, TumCG↓,
7059- GamB,    Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells
- in-vitro, CRC, HCT15
TumCP↓, Apoptosis↑, JNK↑, TumCCA↑, cycD1/CCND1↓, P53↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, MMP↓, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓,
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, PI3K↓, Akt↓, STAT3↓, STAT5↓, IL6↓, COX2/PTGS2↓, iNOS↓, MMPs↓, Src↓, PKA↓, CXCR4↑, VEGF↓, Bcl-2↓, Bcl-xL↓, IAP1↓, Mcl-1↓, survivin↓, cycD1/CCND1↓, HSP90↓, HSP70/HSPA5↓, MAPK↓, HATs↓, HDAC↓, FAK↓, ROS↑, MMP7↓, MMP9↓, α-tubulin↑, cl‑PARP↑, TNF-α↓, BID↑, BAD↑, Cyt‑c↑, Casp3↑, Casp9↑, *AntiArt↑, *antiPs↑,
1967- GamB,    Gambogic acid induces apoptotic cell death in T98G glioma cells
- in-vitro, GBM, T98G
BAX↑, AIF↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↓, Bcl-2↓, ROS↑,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
5149- GamB,    Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells
- in-vitro, lymphoma, JeKo-1
TumCG↓, Apoptosis↑, selectivity↑, MMP↓, Casp3↑, Casp9↑, Casp8↑, Bax:Bcl2↑,
5151- GamB,    Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway
- in-vitro, ESCC, KYSE-30 - in-vitro, ESCC, KYSE450
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Bcl-2↓, BAX↑, cl‑PARP1↑, cl‑Casp3↑, cl‑Casp9↑, PI3K↓, p‑Akt↓, p‑mTOR↓, PTEN↑,
808- GAR,  CUR,    Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑,
805- GAR,  Cisplatin,  PacT,    Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells
- Review, NA, NA
ERK↓, PI3K/Akt↓, Wnt/(β-catenin)↓, STAT3↓, NF-kB↓, ChemoSen↑, COX2/PTGS2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, VEGF↓, TGF-β↓, HATs↓, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↓, Let-7↑, MMP9↓, TumCCA↑, ROS↑, MMP↓, IL6↓, NOTCH1↓, antiNeop↑,
821- GAR,    Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis
- in-vitro, Liver, Hep3B
ROS↑, CHOP/DDIT3↑, MMP↓, Bax:Bcl2↑, Casp8↑, Casp3↑, Casp9↑, cl‑PARP↑, DFF45↑,
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,
831- GAR,  CUR,    Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, Casp3↑, MMP↓, Cyt‑c↑, proCasp9↑, Bcl-2↓, BAX↑, PARP↓, DNAdam↑, DFF45↓,
795- GAR,    Garcinol—A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, NA, NA
HATs↓, BAX↑, PARP↑, Bcl-2↓, Casp3↑, Casp9↑, DR5↑, cFLIP↓, MMP2↓, MMP9↓, STAT3↓, p‑Akt↓,
7214- GAs,    Ginkgolic Acid Suppresses Nasopharyngeal Carcinoma Growth by Inducing Apoptosis and Inhibiting AKT/NF-κB Signaling
- vitro+vivo, NPC, CNE2
tumCV↓, TumCI↓, Apoptosis↑, Bcl-2↓, BAX↑, PARP↑, Casp3↑, Casp9↑, TumCCA↑, CDK6↓, CycD3↓, ChemoSen↑,
7212- GBE,    The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *mitResp↑, *Casp9↓, *Casp3↓, *Apoptosis↓, *ATP↑, *neuroP↑, *IL1β↓, *IL6↓, *TNF-α↓, *PGE2↓, *memory↑, *cognitive↑, *BloodF↑, *lipid-P↓, *Aβ↓, *MAOA↓, *DA↑, *Dose↝, *toxicity↓,
6567- Ger,    Geraniin inhibits proliferation and induces apoptosis through inhibition of phosphatidylinositol 3-kinase/Akt pathway in human colorectal cancer in vitro and in vivo
- vitro+vivo, CRC, SW480 - in-vitro, CRC, HT29
AntiTum↑, *Inflam↓, *antiOx↓, TumCP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑PI3K↓, p‑Akt↓, Dose↝, TumCG↓,
6569- Ger,    Geraniol inhibits cell growth and promotes caspase-dependent apoptosis in nasopharyngeal cancer C666-1 cells via inhibiting PI3K/Akt/mTOR signaling pathway
- in-vitro, NPC, C666-1
tumCV↓, MMP↓, Apoptosis↑, TBARS↑, GSH↓, SOD↓, BAX↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, mTOR↓, DNAdam↑, ROS↑,
6573- Ger,    Systematic elucidation of the mechanism of geraniol via network pharmacology
- Study, Nor, NA - Study, Var, NA
HO-1↝, HRAS↓, *IL8↓, *AChE↓, NF-kB↓, PCNA↓, BAX↑, Bcl-2↓, P53↑, Casp3↑, Casp8↑, Casp9↑,
7138- GI,    6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Pca, DU145 - in-vitro, Liver, HepG2 - in-vitro, Lung, A549
TumCP↓, TumMeta↓, p‑STAT3↓, JAK2↓, cSrc↓, JNK↑, p38↑, ERK↑, eff↓, ROS↑, cl‑PARP↑, TumCCA↑, Casp8↑, Casp9↑, Casp3↑, eff↑, Bcl-2↑, Bcl-xL↓, survivin↓, MMP9↓, COX2/PTGS2↓, IAP1↓, Dose?,
7261- Gink,    Ginkgetin induces apoptosis in 786-O cell line via suppression of JAK2-STAT3 pathway
- in-vitro, RCC, 786-O
TumCG↓, Casp3↑, Casp8↑, Casp9↑, JAK2↓, STAT3↓,
7247- Gink,    Ginkgetin inhibits growth of breast carcinoma via regulating MAPKs pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT474 - vitro+vivo, BC, MCF7
TumCP↓, Apoptosis↑, TumCG↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, survivin↓, p‑ERK↑, cl‑JNK↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
7260- Gink,    Ginkgetin: A natural biflavone with versatile pharmacological activities
- Review, Var, NA - Review, Stroke, NA - Review, AD, NA
*AntiCan↑, *Inflam↓, *AntiBio↑, *neuroP↑, *TumCCA↑, Apoptosis↑, TumAuto↑, iNOS↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PLA2↓, *neuroP↑, *Stroke↓, *AntiFungal↓, *Bacteria↓, Bcl-xL↓, Bcl-2↓, Casp9↑, Casp3↑, cl‑PARP↑, IL6↓, STAT3↓, JAK1↓, survivin↓, COX2/PTGS2↓, IAP1↓, MMP2↓, MMP9↓, PTEN↑, SHP1↑, eff↑, TumVol↓, TumW↓, *toxicity↓, *ROS↓,
7257- Gink,    Ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through inhibition of STAT3 and activation of caspase-3/9
- in-vitro, OS, NA
TumCG↓, Apoptosis↑, STAT3↓, Casp3↑, Casp9↑,
7284- Gins,  5-FU,    Ginsenoside Rg3 enhances the anticancer effect of 5-FU in colon cancer cells via the PI3K/AKT pathway
- vitro+vivo, CRC, SW-620 - in-vitro, CRC, LoVo
ChemoSen↑, TumCP↓, TumCI↓, TumCMig↓, APAF1↑, Casp9↑, Casp3↑, TumCCA↑, cycD1/CCND1↑, CDK2↑, CDK4↑, PI3K↓, Akt↓,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
7315- Gos,    Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells
- vitro+vivo, CRC, HT29 - in-vitro, CRC, COLO205
TumCD↑, Casp3↑, Casp6↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-xL↓, ROS↑, i-H2O2↑, eff↓, mtDam↑, MMP↓, Cyt‑c↑, AIF↑, TumCG↓,
7311- Gos,    Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials
- Review, CLL, NA
Dose↝, toxicity↓, PFS↓, OS↑, eff↑, BioAv↑, Bcl-2↓, ROS↑, MOMP↑, Dose↑, Casp3↑, Casp9↑, MMP↑, VEGF↓, APE1/APEX1↓, ChemoSen↑, RadioS↑, toxicity↑, AST↑, ALAT↑,
845- Gra,    A Review on Annona muricata and Its Anticancer Activity
- Review, NA, NA
GlucoseCon↓, ATP↓, HIF-1↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ERK↓, Akt↓, Apoptosis↑, NF-kB↓, ROS↑, Bax:Bcl2↑, MMP↓, Casp3↑, Casp9↑, p‑JNK↓,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
835- Gra,    Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB
- in-vitro, Lung, A549
ROS↑, MMP↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, Apoptosis↑, TumCCA↑,
851- Gra,    Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, CV1
Bcl-2↓, Casp9↑, Casp3↑, other↑, *toxicity↓,
849- Gra,    Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis
- in-vitro, Pca, PC3 - in-vitro, Nor, PNT1A - in-vitro, NA, HeLa
Casp9↑, CXCL1↓, *toxicity↓,
848- Gra,  AgNPs,    Synthesis, Characterization and Evaluation of Antioxidant and Cytotoxic Potential of Annona muricata Root Extract-derived Biogenic Silver Nanoparticles
- in-vitro, CRC, HCT116
ROS↑, PUMA↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,

Showing Research Papers: 251 to 300 of 470
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 470

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

APE1/APEX1↓, 1,   CUL1↝, 1,   CUL5↝, 1,   CX43/GJA1↓, 1,   HLA-I/II↑, 1,   PFS↓, 1,   PLA2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ARE↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 2,   i-H2O2↑, 1,   HO-1↓, 1,   HO-1↝, 1,   lipid-P↓, 1,   NRF2↓, 2,   OXPHOS↓, 1,   ROS↓, 1,   ROS↑, 21,   SOD↓, 1,   TBARS↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 2,   MEK↓, 1,   MMP↓, 15,   MMP↑, 1,   mtDam↑, 3,   OCR↓, 1,   XIAP↓, 5,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↑, 1,   AMPK↑, 1,   CYP3A4↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDH↓, 1,   LDHA↓, 1,   PI3K/Akt↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 11,   p‑Akt↓, 4,   APAF1↑, 2,   Apoptosis↑, 22,   BAD↓, 1,   BAD↑, 1,   Bak↑, 2,   BAX↑, 17,   Bax:Bcl2↑, 6,   Bcl-2↓, 24,   Bcl-2↑, 1,   Bcl-xL↓, 5,   BID↓, 1,   BID↑, 2,   Casp↑, 2,   Casp3↑, 38,   cl‑Casp3↑, 6,   Casp6↑, 1,   Casp7↑, 3,   Casp8↑, 14,   cl‑Casp8↑, 2,   Casp9↑, 39,   cl‑Casp9↑, 6,   proCasp9↑, 1,   cFLIP↓, 3,   Cyt‑c↑, 14,   Diablo↑, 1,   DR5↑, 3,   FADD↑, 1,   Fas↓, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 2,   IAP1↓, 4,   iNOS↓, 2,   JNK↑, 2,   p‑JNK↓, 1,   cl‑JNK↑, 1,   MAPK↓, 2,   Mcl-1↓, 4,   MDM2↓, 2,   MOMP↑, 3,   Myc↓, 1,   NOXA↑, 1,   p27/CDKN1B↑, 2,   p38↑, 1,   PUMA↝, 1,   survivin↓, 10,   Telomerase↓, 1,   TumCD↑, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   FOXD3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HATs↓, 3,   other↑, 1,   other↝, 3,   tumCV↓, 9,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↓, 1,   DFF45↑, 1,   DNAdam↑, 4,   DNArepair↓, 1,   P53↓, 1,   P53↑, 5,   PARP↓, 1,   PARP↑, 5,   cl‑PARP↓, 2,   cl‑PARP↑, 11,   cl‑PARP1↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK2↓, 1,   CDK2↑, 2,   CDK4↓, 2,   CDK4↑, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 7,   cycD1/CCND1↑, 1,   CycD3↓, 1,   cycE/CCNE↓, 2,   mitA↑, 1,   P21↑, 3,   TumCCA↑, 16,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   EMT↓, 1,   ERK↓, 6,   ERK↑, 1,   p‑ERK↓, 2,   p‑ERK↑, 1,   FGF↓, 1,   GSK‐3β↑, 1,   HDAC↓, 2,   HRAS↓, 1,   Let-7↑, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   NOTCH1↓, 1,   PI3K↓, 8,   p‑PI3K↓, 1,   PTEN↑, 3,   SHP1↑, 1,   Src↓, 1,   STAT3↓, 8,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT5↓, 1,   TumCG↓, 10,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   i-Ca+2↑, 2,   E-cadherin↑, 1,   EM↑, 1,   FAK↓, 2,   LAMs↓, 1,   MMP2↓, 7,   MMP7↓, 1,   MMP9↓, 10,   MMPs↓, 3,   PKA↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCA↓, 1,   TumCI↓, 9,   TumCMig↓, 7,   TumCP↓, 8,   TumMeta↓, 4,   Twist↓, 1,   Vim↓, 1,   Zeb1↓, 1,   ZEB2↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   EGFR↓, 2,   HIF-1↓, 1,   Hif1a↓, 4,   VEGF↓, 12,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 1,   GLUT4↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   CXCL1↓, 1,   CXCR4↑, 1,   ICAM-1↓, 1,   IL6↓, 4,   Imm↑, 2,   Inflam↓, 1,   JAK1↓, 1,   JAK2↓, 2,   NF-kB↓, 9,   PD-1↓, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   CDK6↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioAv↝, 2,   ChemoSen↑, 13,   Dose?, 1,   Dose↑, 1,   Dose↝, 7,   eff↓, 4,   eff↑, 10,   eff↝, 1,   eff∅, 1,   RadioS↑, 3,   selectivity↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↑, 1,   AST↑, 1,   EGFR↓, 2,   hTERT/TERT↓, 2,   IL6↓, 4,   LDH↓, 1,   Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   antiNeop↑, 1,   AntiTum↑, 3,   chemoP↑, 4,   chemoPv↑, 1,   NP/CIPN↓, 1,   OS↑, 1,   QoL↑, 1,   radioP↑, 2,   toxicity↓, 2,   toxicity↑, 1,   TumVol↓, 3,   TumW↓, 3,  
Total Targets: 245

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 1,   DA↑, 1,   SpO2↑, 1,   Stroke↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   Catalase↑, 4,   Fenton↓, 1,   GPx↑, 3,   GSH↑, 2,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 1,   Keap1↝, 1,   lipid-P↓, 3,   MDA↓, 4,   MPO↓, 1,   NOX4↓, 1,   NRF2↑, 3,   RNS↓, 1,   ROS↓, 8,   mt-ROS?, 1,   SOD↑, 2,   TBARS↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↑, 2,   Insulin↑, 1,   mitResp↑, 1,   MMP↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   BUN↓, 1,   glucose↓, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Apoptosis↓, 3,   ASK1↓, 1,   Bax:Bcl2↝, 1,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp3↓, 4,   Casp9↓, 4,   Cyt‑c↓, 1,   p‑JNK↓, 1,   TUNEL↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 1,   STAT3↑, 1,  

Migration(tgid=13) ⓘ

COL1↓, 1,   E-cadherin↑, 1,   Treg lymp↝, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   VCAM-1↓, 1,   Vim↓, 1,   α-SMA↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 4,   IL4↑, 1,   IL6↓, 4,   IL8↓, 1,   Inflam↓, 6,   JAK2↑, 1,   LPS↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 3,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 4,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 2,   AChE↑, 1,   BDNF↑, 1,   MAOA↓, 1,   NGF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 5,   BioAv↝, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 3,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AST↓, 3,   BloodF↑, 1,   creat↓, 2,   GutMicro↑, 1,   IL6↓, 4,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   antiNeop↑, 1,   antiPs↑, 2,   cardioP↑, 2,   chemoP↑, 2,   cognitive↑, 2,   hepatoP↑, 3,   memory↑, 2,   neuroP↑, 5,   Obesity↓, 1,   OS↑, 1,   toxicity↓, 8,   toxicity↑, 1,   toxicity↝, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1,   AntiViral↑, 1,   Bacteria↓, 3,  
Total Targets: 137

Scientific Paper Hit Count for: Casp9, Caspase-9
20 Quercetin
18 Silver-NanoParticles
18 Baicalein
16 Curcumin
15 Emodin
15 Thymoquinone
14 Fisetin
12 Sulforaphane (mainly Broccoli)
11 Apigenin (mainly Parsley)
9 Allicin (mainly Garlic)
9 Berberine
9 Betulinic acid
9 Chrysin
8 Honokiol
8 Luteolin
8 Silymarin (Milk Thistle) silibinin
7 Cisplatin
7 Artemisinin
7 Alpha-Lipoic-Acid
7 EGCG (Epigallocatechin Gallate)
7 Gambogic Acid
6 Citric Acid
6 D-limonene
6 Eugenol
6 Garcinol
6 Graviola
6 Magnolol
5 Ginkgetin
5 Phenethyl isothiocyanate
5 Shikonin
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Ashwagandha(Withaferin A)
4 Bromelain
4 Boron
4 Capsaicin
4 Carvacrol
4 chaetocin
4 Photodynamic Therapy
4 Formononetin
4 Fucoidan
4 Juglone
4 Lycopene
4 Magnetic Fields
4 Plumbagin
4 Resveratrol
3 5-fluorouracil
3 Berbamine
3 Boswellia (frankincense)
3 α-Bisabolol / Chamomile oil
3 Carnosic acid
3 Chlorogenic acid
3 Radiotherapy/Radiation
3 Dandelion Root
3 Evodiamine
3 Ferulic acid
3 Gallic acid
3 Geraniol
3 Gossypol/AT-101
3 HydroxyTyrosol
3 Hyperoside
3 Isoliquiritigenin
3 isoorientin
3 Vitexin
3 Propolis -bee glue
3 Piperlongumine
3 Selenium NanoParticles
3 Aflavin-3,3′-digallate
2 Astragalus
2 Andrographis
2 Anethole/trans-Anethole
2 Aloe anthraquinones
2 Beta-Caryophyllene
2 Brucea javanica
2 Bullatacin
2 Thymol-Thymus vulgaris
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Carvone
2 Polyphenols
2 Deguelin
2 Echinacea
2 Electrical Pulses
2 Paclitaxel/Taxol
2 Hydrogen Gas
2 Chemotherapy
2 Hibiscus sabdariffa
2 Rutin
2 Isobavachalcone
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 isoquercitrin
2 Nimbolide
2 Oleuropein
2 Rosmarinic acid
2 salinomycin
2 Selenium
2 chitosan
2 Selenite (Sodium)
2 Ursolic acid
1 1,8-Cineole
1 entinostat
1 Camptothecin
1 Resiquimod
1 Gemcitabine (Gemzar)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Fennel Oil/Foeniculum vulgare
1 Metformin
1 2-DeoxyGlucose
1 almonertinib
1 epirubicin
1 Biochanin A
1 Bufalin/Huachansu
1 brusatol
1 borneol
1 Caffeic acid
1 Sorafenib (brand name Nexavar)
1 Celecoxib
1 Chlorophyllin
1 Cinnamon
1 immunotherapy
1 Crocetin
1 Cucurbitacin
1 Cynaropicrin
1 Diclofenac
1 diet Methionine-Restricted Diet
1 Docetaxel
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Geldanamycin
1 Radicicol/monorden
1 olaparib/LYNPARZA
1 Ginkgolic acids
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 Hydroxycinnamic-acid
1 Helleborus niger extracts – Christmas Rose
1 Baicalin
1 Indole-3-carbinol
1 Morin
1 Isovitexin
1 Melatonin
1 Magnetic Field Rotating
1 sericin
1 Propyl gallate
1 Piperine
1 doxorubicin
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 polyethylene glycol
1 Auranofin
1 Terpinen-4-ol / Tea Tree Oil
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Vitamin K2
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:45  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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