Catalase Cancer Research Results

Catalase, Catalase: Click to Expand ⟱
Source:
Type:
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Caspase-1 may have both tumorigenic or antitumorigenic effects on cancer development and progression, but it depends on the type of inflammasome, methodology, and cancer.
Catalase is an enzyme found in nearly all living cells exposed to oxygen. Its primary role is to protect cells from oxidative damage by catalyzing the conversion of hydrogen peroxide (H₂O₂), a potentially damaging byproduct of metabolism, into water (H₂O) and oxygen (O₂). This detoxification process is crucial because excess H₂O₂ can lead to the formation of reactive oxygen species (ROS) that damage proteins, lipids, and DNA.

Catalase and Cancer
Oxidative Stress and Cancer:
Cancer cells often experience increased levels of oxidative stress due to rapid proliferation and metabolic changes. This stress can lead to DNA damage, promoting tumorigenesis.
Catalase helps mitigate oxidative stress, and its expression can influence the survival and proliferation of cancer cells.
Expression Levels in Different Cancers:
Overexpression: In some cancers, such as breast cancer and certain types of leukemia, catalase may be overexpressed. This overexpression can help cancer cells survive in oxidative environments, potentially leading to more aggressive tumor behavior.
Downregulation: Conversely, in other cancers, such as colorectal cancer, reduced catalase expression has been observed. This downregulation can lead to increased oxidative stress, contributing to tumor progression and metastasis.
Prognostic Implications:
Survival Rates: Studies have shown that high levels of catalase expression can be associated with poor prognosis in certain cancers, as it may enable cancer cells to resist apoptosis (programmed cell death) induced by oxidative stress.

Some types of cancer cells have been reported to exhibit lower catalase activity, possibly increasing their vulnerability to oxidative damage under certain conditions. This vulnerability has even been exploited in some therapeutic strategies (for example, approaches that generate excess H₂O₂ or other ROS specifically targeting cancer cells have been researched).
Scientific Papers found: Click to Expand⟱
8770- MSM,  Cisplatin,    Methylsulfonylmethane (MSM) Mitigates Cisplatin-Induced Early Oxidative Testicular Dysfunction Through Modulation of Antioxidant Defense and GPX4 Response
- in-vivo, Nor, NA
*Dose?, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *testos↑, *GPx4↓, *chemoP↑,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
946- Nimb,    Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis
- in-vivo, Var, NA
Apoptosis↑, Bcl-2↓, P53↑, cl‑Casp3↑, Cyt‑c↑, ROS↑, SOD↓, Catalase↓, Glycolysis↓, GLUT3↓, LDHA↓, MCT1↓, NHE1↓, ATPase↓, CAIX/CA9↓,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27/CDKN1B↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
8453- OM,    Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress
- in-vivo, Nor, NA
Dose↝, creat↓, Urea↓, uricA↓, BUN↓, MDA↓, GSH↑, SOD↑, Catalase↑, RenoP↑, *ROS↓,
8434- OM,    Traditional use, phytochemistry, toxicology, and pharmacology of Origanum majorana L
- Review, Var, NA
*Bacteria↓, *AntiFungal↑, *antiOx↑, *AntiP↑, *AntiDiabetic↑, *AntiCan↑, *RenoP↑, *Inflam↓, *Analgesic↑, *antiPy↑, *antiM↑, *Ingr↝, *Ingr↝, *creat↓, *Urea↓, *uricA↓, *BUN↓, *ALAT↓, *AST↓, *ALP↓, *Catalase↑, *SOD↑, *GSTA1↑,
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, Nor, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2/PTGS2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓, *antiAll↑,
3251- PBG,    The Antioxidant and Anti-Inflammatory Effects of Flavonoids from Propolis via Nrf2 and NF-κB Pathways
- Review, AD, NA - Review, Diabetic, NA - Review, Var, NA - in-vitro, Nor, H9c2
*antiOx↑, *Inflam↓, *ROS↓, *SOD↑, *Catalase↑, *HO-1↑, *NO↓, *NOS2↓, *NF-kB↓, *NRF2↑, *hepatoP↑, *MDA↓, *mtDam↓, *GSH↑, *p65↓, *TNF-α↓, *IL1β↓, *NRF2↑, *NRF2↓, *ROS⇅, *BioAv↓, *BioAv↑,
3259- PBG,    Propolis and its therapeutic effects on renal diseases: A review
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *NO↓, *NF-kB↓, TumCP↓, angioG↓, VEGF↓, STAT↓, Hif1a↓, RenoP↑, TLR4↓, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *toxicity∅,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2/PTGS2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,
1767- PG,    Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathione
- in-vitro, Nor, NA
*ROS↑, *GSH↓, *SOD↓, *Catalase↓, eff↓,
3595- PI,    Black pepper and health claims: a comprehensive treatise
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *Synergy↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,
3596- PI,    Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
- in-vivo, Nor, NA
*TBARS↑, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *GSH↑, *ROS↓,
2969- PL,    Piperlongumine induces autophagy by targeting p38 signaling
- in-vitro, OS, U2OS - in-vitro, Cerv, HeLa
p38↑, ROS↑, GPx1∅, SOD∅, Catalase∅,
1942- PL,    Piperlongumine inhibits antioxidant enzymes, increases ROS levels, induces DNA damage and G2/M cell cycle arrest in breast cell lines
- in-vitro, BC, MCF7
ROS↑, SOD1↑, Trx1↓, Catalase↓, PrxII↓, ROS↑, GADD45A↑, P21↑, DNAdam↑, TumCCA↑,
1987- PTL,  Rad,    A NADPH oxidase dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Nor, PrEC
selectivity↑, RadioS↑, ROS↑, *ROS∅, NADPH↑, Trx↓, PI3K↑, Akt↑, p‑FOXO3↓, SOD2↓, Catalase↓, radioP↑, *NADPH∅, *GSH↑, *GSH/GSSG↑, *NRF2↑,
4703- PTS,  RES,    Pterostilbene and resveratrol: Exploring their protective mechanisms against skin photoaging - A scoping review
- in-vivo, Nor, NA
*AntiAge↑, *eff↑, *Inflam↓, *AntiCan↑, *ROS↓, *Catalase↑, *GSR↑, *HO-1↑, *NAD↑, *NQO1↑, *SOD↑, *NRF2↑,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2/PTGS2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2/PTGS2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1/CCL2↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
2343- QC,    Pharmacological Activity of Quercetin: An Updated Review
- Review, Nor, NA
*ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *GPx↑, *Copper↓, *Iron↓, Apoptosis↓, TumCCA↑, MMP2↓, MMP9↓, GlucoseCon↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, ROS↑,
4827- QC,  CUR,    Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin
- Review, Var, NA
*AntiCan↑, *Inflam↓, *Bacteria↓, *AntiDiabetic↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *NRF2↑, *Trx↑, *IronCh↑, *MDA↑, cycD1/CCND1↓, PI3K↓, Casp3↑, BAX↑, ChemoSen↑, ROS↑, Synergy↑, MMP↓, Cyt‑c↑, Akt↓, ERK↓,
5025- QC,    New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
- Review, Nor, NA
*antiOx↑, *Inflam↓, *NRF2↓, *ROS↓, *cardioP↑, *HO-1↑, *Catalase↑, *GPx↑, *NQO1↑, *SIRT1↑,
3349- QC,    Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression
- in-vivo, Sepsis, NA
*Sepsis↓, *ROS↓, *SOD↑, *Catalase↑, *HMGB1↓, *Inflam↓, *TAC↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, Synergy↑, HIF-1↓,
79- QC,    Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats
- in-vivo, Pca, NA
GSH↑, SOD↑, Catalase↑, GPx↑, GSR↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, lipid-P↓, H2O2↓, Raf↓, p‑MEK↓, Bcl-2↑, Bcl-xL↑, Casp3↑, Casp8↑, Casp9↑,
2443- RES,    Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review
- Review, Var, NA
*antiOx↑, *ROS↓, *PTEN↑, *Akt↓, *Catalase↑, *SOD↑, *ERK↓, *GSH↑, *AMPK↑, *FOXO1↝, *RNS↓, *Catalase↑, *cardioP↑, *PI3K↑, *eNOS↑, hepatoP↑,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2/PTGS2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, Synergy↑, Synergy↑, Synergy↑,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2/PTGS2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
3068- RES,    Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation
- in-vitro, lymphoma, U937
p65↓, SOD2↓, Prx↓, Catalase↓, Trx↓, TNF-α↓, IL8↓, MCP1/CCL2↓, SIRT1↑,
3612- RES,    Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential
- Review, AD, NA
*other↑, *Aβ↓, *Inflam↓, *NF-kB↓, *neuroP↑, *HO-1↑, *lipid-P↓, *COX2/PTGS2↓, *AMPK↑, *Catalase↑, *SOD↑, *GSR↑, *ROS↓, *MMP9↓, *cognitive↑, *SIRT1↑, *IL1β↓, *IL6↓,
3616- RosA,    Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders
- Review, AD, NA
*Inflam↓, *memory↑, *toxicity↓, *ROS↓, *Catalase↑, *SOD↑, *NRF2↑, *Aβ↓, *AChE↓, *Ca+2↓, *NO↓, *IL2↓, *COX2/PTGS2↓, *PGE2↓, *MMPs↓, *TNF-α↓, *iNOS↓, *TLR4↓, *cognitive↑, *cortisol↓, *lipid-P↓,
3024- RosA,    rmMANF prevents sepsis-associated lung injury via inhibiting endoplasmic reticulum stress-induced ferroptosis in mice
- in-vivo, Sepsis, NA
*Ferroptosis↓, *GRP78/BiP↓, *PERK↓, *ATF4↓, *Sepsis↓, *GSH↑, *SOD↑, *Catalase↑,
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑, *antiAll↑,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp/ABCB1↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2/PTGS2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
1749- RosA,    Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer
- Review, Var, NA
antiOx↑, eff↑, *toxicity↝, *BioAv↑, *ROS↓, SOD↑, Catalase↑, GPx↑, lipid-P↓, P450↓, chemoP↑, hepatoP↑, ChemoSen↑,
323- Sal,  AgNPs,    Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy
- in-vitro, BC, MDA-MB-231 - in-vitro, Ovarian, A2780S
TumCD↑, LDH↓, MDA↑, SOD↓, ROS↑, GSH↓, Catalase↓, MMP↓, P53↑, P21↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Apoptosis↑, TumAuto↑,
4908- Sal,    Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
tumCV↓, ROS↑, lipid-P↑, UPR↑, ER Stress↑, NRF2↓, NADPH↓, HO-1↓, SOD↓, Catalase↓, GPx↓, eff↓, TumCP↓,
4726- Se,  Oxy,    Oxygen therapy accelerates apoptosis induced by selenium compounds via regulating Nrf2/MAPK signaling pathway in hepatocellular carcinoma
- in-vivo, HCC, NA
eff↝, NRF2↓, p‑p38↑, Apoptosis↑, eff↑, TumVol↓, other↝, toxicity↓, Dose↝, NRF2↝, HO-1↓, Catalase↓, SOD↓, e-pH↓, pH∅, MAPK↑, eff↑,
4601- SeNPs,  AgNPs,    Antioxidant and hepatoprotective role of selenium against silver nanoparticles
- in-vivo, Nor, NA
*TAC↑, *CRP↓, *AST↓, *ALAT↓, *toxicity↓, *GSH↑, *SOD↑, *Catalase↑, *hepatoP↑,
4735- SeNPs,    Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum
- in-vivo, Nor, NA
*MDA↓, *H2O2↓, *Catalase↑, *SOD↑, *GSTs↑, *GSH↑, *NRF2↓, *ATG3↓, *AMPK↓, *ROS↓,
4446- SeNPs,    Antioxidant and Hepatoprotective Effects of Moringa oleifera-mediated Selenium Nanoparticles in Diabetic Rats.
- in-vivo, Diabetic, NA
*glucose↓, *antiOx↑, *GPx↑, *Catalase↑, *SOD↑, *ROS↓, *cardioP↑, *HDL↑, *LDL↓, *hepatoP↑, *TNF-α↓, *IL6↓, *IL1β↓, *lipid-P↓, *Inflam↓, *ALAT↓, *AST↓, *ALP↓, *Dose↝, *Dose↝,
4453- SeNPs,    Selenium Nanoparticles: Green Synthesis and Biomedical Application
- Review, Var, NA
*toxicity↓, *Bacteria↓, ROS↑, MMP↓, ER Stress↑, P53↑, Apoptosis↑, Casp9↑, DNAdam↑, TumCCA↑, eff↑, Catalase↓, SOD↓, GSH↓, selectivity↓, selectivity↑, PCNA↓, eff↑, *ALAT↓, *AST↓, *ALP↓, *creat↓, *Inflam↓, *toxicity↓, selectivity↑,
4444- SeNPs,    Antioxidant and Hepatoprotective Efficiency of Selenium Nanoparticles Against Acetaminophen-Induced Hepatic Damage
- in-vivo, LiverDam, NA
*hepatoP↑, *ROS↓, *Catalase↑, *SOD↑, *GSH↑, *DNAdam↓,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, Nor, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
4199- SFN,    Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders
- Review, AD, NA - Review, Park, NA
*BBB↑, *BDNF↑, *neuroG↑, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *HSPs↑, *GSTs↑, *Trx↑, *GPx↑, *GSR↑, *GSH↑, *NQO1↑, *GutMicro↑, *Inflam↓, *neuroP↑,

Showing Research Papers: 251 to 300 of 346
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 346

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 11,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 44,   Catalase↑, 34,   Catalase↝, 1,   Catalase∅, 2,   GCLM↑, 2,   GPx↓, 8,   GPx↑, 19,   GPx1⇅, 1,   GPx1∅, 1,   GPx4↓, 4,   GSH↓, 30,   GSH↑, 15,   GSH/GSSG↓, 2,   GSR↓, 1,   GSR↑, 4,   GSS↑, 1,   GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 4,   GSTs∅, 1,   H2O2↓, 3,   H2O2↑, 2,   HO-1↓, 6,   HO-1↑, 12,   Iron↑, 1,   i-Iron↑, 1,   lipid-P↓, 5,   lipid-P↑, 9,   MDA?, 1,   MDA↓, 8,   MDA↑, 12,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 3,   NRF2↓, 12,   NRF2↑, 18,   NRF2↝, 1,   Prx↓, 2,   PrxII↓, 1,   ROS↓, 27,   ROS↑, 97,   ROS⇅, 2,   ROS↝, 1,   i-ROS↑, 1,   SAM-e↝, 1,   SOD?, 1,   SOD↓, 27,   SOD↑, 25,   SOD∅, 1,   SOD1↓, 2,   SOD1↑, 3,   SOD2↓, 7,   SOD2↑, 2,   T-SOD↓, 1,   TAC↓, 3,   TBARS↑, 1,   Thiols↓, 1,   TOS↑, 1,   Trx↓, 2,   Trx1↓, 1,   Trx1↑, 1,   TrxR↓, 1,   uricA↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 1,   CDC25↓, 4,   compI↓, 1,   compIII↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 7,   OCR↑, 2,   OXPHOS↑, 4,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↓, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 2,   ALAT↓, 3,   AMP↑, 1,   AMPK↓, 1,   AMPK↑, 5,   ATP↓, 7,   ATP↑, 2,   mt-ATP↓, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 1,   FAO↑, 1,   FASN↓, 3,   G6PD↓, 1,   GAPDH↓, 1,   GLO-I↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 12,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 4,   HK2↓, 4,   lactateProd↓, 4,   LDHA↓, 4,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 2,   NADPH↑, 4,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PKM2↓, 3,   Pyruv↓, 1,   SCD1↓, 1,   SIRT1↓, 4,   SIRT1↑, 4,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 7,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 5,   Apoptosis↓, 5,   Apoptosis↑, 74,   ASC↓, 1,   BAD↓, 1,   BAD↑, 4,   Bak↓, 1,   Bak↑, 2,   BAX↓, 4,   BAX↑, 47,   Bax:Bcl2↑, 6,   Bcl-2↓, 48,   Bcl-2↑, 3,   Bcl-xL↓, 9,   Bcl-xL↑, 1,   BID↑, 2,   BIM↑, 1,   BNIP3↑, 1,   Casp↑, 10,   Casp↝, 1,   Casp1↓, 1,   Casp3↓, 2,   Casp3↑, 53,   cl‑Casp3↑, 7,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 17,   cl‑Casp8↑, 1,   Casp9↑, 37,   cl‑Casp9↑, 6,   proCasp9↓, 1,   cFLIP↓, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 26,   mt-Cyt‑c↓, 1,   Diablo↑, 1,   DR5↑, 6,   FADD↑, 1,   Fas↑, 10,   FasL↑, 2,   Ferroptosis↑, 1,   GSDMD↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 4,   iNOS↑, 1,   Mcl-1↓, 1,   MDM2↓, 3,   p‑MDM2↓, 1,   Necroptosis↑, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 7,   p‑p38↑, 3,   pS2/TFF1↑, 1,   PUMA↑, 3,   survivin↓, 9,   TumCD↑, 9,   XIAP↓, 9,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 44,   Akt↑, 5,   p‑Akt↓, 12,   AMPKα↑, 1,   BRAF↑, 1,   BRAF↝, 1,   CK2↓, 2,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 9,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 16,   ERK↑, 1,   p‑ERK↓, 4,   FGFR1↓, 2,   FGFR2↓, 1,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   IGF-1R↓, 3,   IKKα↓, 1,   JAK↓, 2,   JAK1↓, 1,   JAK2↓, 2,   JNK↓, 2,   JNK↑, 9,   p‑JNK↓, 1,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 9,   MAPK↑, 11,   MAPK↝, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   p‑MEK↓, 2,   MKK4↓, 1,   mTOR↓, 25,   mTOR↝, 1,   p‑mTOR↓, 4,   P70S6K↓, 3,   p‑P70S6K↓, 1,   PI3K↓, 33,   PI3K↑, 3,   p‑PI3K↓, 2,   p‑PI3K↑, 1,   PI3K/Akt↓, 2,   PI3K/Akt↝, 1,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 5,   PTEN↝, 1,   Raf↓, 2,   RAS↓, 5,   RAS↑, 1,   Sp1/3/4↓, 4,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 24,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   p‑STAT6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3,   cJun↓, 1,   cMyc↓, 8,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 2,   EZH2↓, 2,   FOXM1↓, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 3,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HATs↓, 1,   HDAC↓, 8,   HDAC1↓, 3,   HDAC2↓, 5,   HDAC3↓, 3,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-21↓, 1,   miR-22↑, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   OCT4↓, 4,   other?, 1,   other↓, 5,   other↑, 7,   other↝, 1,   PAX2↓, 1,   PhotoS↑, 1,   SOX2↓, 1,   SOX9↓, 1,   TET3↑, 1,   tumCV?, 1,   tumCV↓, 19,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 5,   eIF2α↑, 3,   p‑eIF2α↑, 1,   ER Stress↑, 14,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 5,   HSPs↑, 2,   NQO2↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 7,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 3,   MitoP↑, 1,   p62↓, 2,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 14,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↓, 2,   DNAdam↑, 22,   DNArepair↑, 1,   hTERT/TERT↓, 2,   P53↓, 2,   P53↑, 40,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 8,   cl‑PARP↓, 1,   cl‑PARP↑, 16,   PCNA↓, 13,   SIRT6↓, 1,   Telomerase↓, 3,   TOP1↓, 3,   TOP2↓, 3,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 1,   CDK1↑, 2,   p‑CDK1↓, 1,   CDK2↓, 12,   CDK2↑, 2,   CDK4↓, 16,   CDK6↓, 3,   CDK6↑, 1,   CDKN1C/p57↑, 1,   CHK1↓, 1,   Chk2↓, 1,   Cyc↓, 3,   cycA1/CCNA1↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 21,   cycE/CCNE↓, 4,   cycE/CCNE↑, 1,   E2Fs↓, 2,   GADD45A↑, 1,   Ki-67↓, 8,   mitA↑, 1,   P21↓, 2,   P21↑, 21,   p27/CDKN1B↑, 10,   pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 63,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs↓, 5,   Diff↑, 1,   EIF4E↓, 1,   FGF↓, 2,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 6,   IGFBP3↑, 1,   Ki-67↓, 8,   mTORC1↓, 1,   Nanog↓, 2,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↓, 4,   NOTCH1↑, 1,   Shh↓, 2,   Smo↓, 1,   TumCG↓, 17,   TumCG↑, 2,   TumCP↓, 44,   tyrosinase↓, 1,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   ATPase↓, 1,   AXL↓, 2,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↑, 6,   Ca+2↝, 1,   i-Ca+2↑, 2,   cal2↓, 1,   CD11b↑, 1,   Cdc42↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 12,   EMT↓, 19,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 1,   FAK↓, 5,   p‑FAK↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   LAMs↓, 1,   LRP1↓, 1,   LRP1↑, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 2,   MMP13↓, 2,   MMP2↓, 23,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 28,   MMP9↑, 2,   MMPs↓, 10,   MTA1↓, 1,   N-cadherin↓, 11,   PDGF↓, 2,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   Rho↝, 1,   ROCK1↓, 2,   Slug?, 1,   Slug↓, 1,   Smad1↓, 1,   Smad1↑, 1,   Snail?, 1,   Snail↓, 3,   TET1↑, 3,   TGF-β↓, 3,   TIMP1↑, 4,   TIMP2↓, 2,   TIMP2↑, 4,   TIMP3↑, 1,   TumCI↓, 21,   TumCMig↓, 21,   TumMeta↓, 21,   TumMeta↑, 2,   Twist↓, 6,   Tyro3↓, 1,   uPA↓, 2,   uPAR↓, 1,   Vim↓, 10,   Vim↑, 1,   Zeb1↓, 2,   ZEB2↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 27,   angioG↑, 1,   CD31/PECAM-1↓, 2,   HIF-1↓, 2,   Hif1a↓, 21,   Hif1a↑, 1,   NO↓, 4,   NO↑, 3,   VCAM-1↓, 1,   VEGF↓, 35,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB∅, 1,   CLDN1↓, 2,   GLUT1↓, 4,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   MMP↓, 39,   MMP↑, 2,   NHE1↓, 1,   TRPM7↓, 1,   TRPV1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 4,   CD47↓, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 32,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCR4↓, 4,   DR4↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 4,   IFN-γ↓, 3,   IL1↓, 4,   IL1↑, 1,   IL10↑, 2,   IL1β↓, 6,   IL2↓, 2,   IL2↑, 3,   IL4↓, 2,   IL4↑, 2,   IL6↓, 22,   IL8↓, 6,   Imm↑, 3,   Imm↝, 1,   Inflam↓, 11,   Inflam↑, 1,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MIP2↓, 1,   NF-kB↓, 42,   NF-kB↑, 2,   p‑NF-kB↑, 1,   NK cell↑, 6,   NLRP3↓, 2,   NLRP3↑, 2,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 6,   PGE1↓, 1,   PGE2↓, 10,   PSA↓, 3,   PSA∅, 1,   RAGE↓, 1,   Resistin↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 3,   TNF-α↓, 20,   TNF-α↑, 3,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,   pH∅, 1,   e-pH↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   PRNP↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6,   ERα/ESR1↓, 2,   Estro↝, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARγ↓, 1,   PPARγ↑, 3,   PPARγ↝, 1,   PR↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12,   BioAv↑, 8,   BioAv↝, 5,   ChemoSen↑, 52,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A2↓, 1,   DDS↑, 1,   Dose↑, 2,   Dose↝, 22,   Dose∅, 3,   eff↓, 12,   eff↑, 29,   eff↝, 3,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P-gp/ABCB1↑, 1,   P450↓, 2,   RadioS↑, 17,   selectivity↓, 1,   selectivity↑, 34,   Synergy↑, 38,   TET2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 3,   AR↓, 6,   AST↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 1,   BRAF↑, 1,   BRAF↝, 1,   BRCA1↑, 1,   BUN↓, 1,   CEA↓, 2,   creat↓, 1,   CRP↓, 1,   EGFR↓, 9,   EGFR↑, 2,   p‑EGFR↓, 1,   ERα/ESR1↓, 2,   EZH2↓, 2,   FOXM1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 2,   IL6↓, 22,   KRAS↓, 1,   LDH↓, 2,   LDH↝, 1,   NSE↓, 1,   PD-L1↓, 6,   PSA↓, 3,   PSA∅, 1,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 28,   antiNeop↑, 1,   AntiTum↑, 5,   Appetite↑, 1,   BowelM↑, 1,   cachexia↓, 2,   cardioP↑, 10,   chemoP↑, 19,   chemoPv↑, 5,   ChemoSideEff↓, 1,   cognitive↑, 3,   fatigue↓, 1,   hepatoP↑, 10,   Mucositis↓, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   OS↑, 9,   Pain↓, 3,   PFS↑, 1,   Pin1↓, 1,   QoL↑, 6,   radioP↑, 10,   RenoP↑, 5,   Risk↓, 6,   Sleep↑, 2,   toxicity↓, 4,   toxicity↝, 2,   TumVol↓, 12,   TumW↓, 2,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 671

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx?, 2,   antiOx↓, 2,   antiOx↑, 128,   ARE↑, 5,   Bil↓, 1,   Bil↑, 1,   Catalase↓, 9,   Catalase↑, 265,   Catalase↝, 2,   Copper↓, 1,   Fenton↓, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 5,   GPx↑, 120,   GPx↝, 1,   GPx1↑, 5,   GPx3↑, 1,   GPx4↓, 1,   GPx4↑, 5,   GSH↓, 4,   GSH↑, 131,   GSH∅, 1,   GSH/GSSG↓, 1,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 25,   GSTs↓, 1,   GSTs↑, 36,   H2O2↓, 11,   HDL↓, 1,   HDL↑, 5,   HO-1↓, 3,   HO-1↑, 74,   HO-1⇅, 1,   Iron↓, 2,   i-Iron↓, 1,   i-Iron↑, 1,   Keap1↓, 5,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 88,   MDA↓, 108,   MDA↑, 4,   MPO↓, 6,   MPO↑, 1,   NADH↓, 1,   NOX↓, 3,   NOX4↓, 3,   NQO1↑, 15,   Nrf1↑, 2,   NRF2↓, 4,   NRF2↑, 112,   Prx↑, 4,   RNS↓, 5,   ROMO1↑, 1,   ROS?, 2,   ROS↓, 220,   ROS↑, 4,   ROS⇅, 1,   ROS∅, 2,   mt-ROS?, 1,   mt-ROS↓, 3,   SAM-e↑, 1,   SOD?, 2,   SOD↓, 7,   SOD↑, 220,   SOD↝, 2,   SOD1↑, 9,   SOD2↑, 7,   TAC↑, 18,   TBARS↓, 5,   TBARS↑, 1,   Thiols↑, 3,   TOS↓, 1,   Trx↓, 1,   Trx↑, 3,   Trx1↑, 3,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 8,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   EGF↓, 1,   ETC↑, 1,   HSP60/HSPD1↓, 1,   Insulin↑, 3,   MFN1↑, 1,   MFN2↑, 1,   mtDam↓, 7,   NGB↑, 1,   OCR↑, 1,   OPA1↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 3,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 6,   ACC↓, 1,   ACC↑, 1,   mt-ACC⇅, 1,   ACSL4↓, 1,   ALAT↓, 35,   ALAT↑, 1,   ALAT∅, 1,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 9,   ATP↑, 13,   ATP↝, 1,   Buty↑, 1,   cAMP↑, 1,   CRM↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 2,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 6,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 3,   Glycolysis↝, 1,   GSK‐3β↓, 12,   GSK‐3β↑, 1,   H2S↑, 2,   HK2↓, 1,   HK2↑, 1,   HMG-CoA↓, 2,   IDH1↑, 1,   LDL↓, 14,   NAD↑, 2,   NAD↝, 1,   NADPH↓, 8,   NADPH↑, 7,   NADPH∅, 1,   PDKs↑, 1,   PFK↓, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↑, 15,   SREBP1/SREBF1↓, 1,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 22,   ASC↓, 1,   ASK1↓, 1,   BAD↓, 1,   BAX↓, 19,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-2↑, 16,   Bcl-2↝, 1,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 28,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp8↓, 1,   Casp9↓, 9,   Cyt‑c↓, 4,   Fas↓, 1,   Ferroptosis↓, 5,   GranB/GZMB↓, 1,   iNOS↓, 32,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 6,   p38↑, 1,   p‑p38↓, 1,   survivin↓, 1,   TUNEL↓, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 14,   p‑Akt↓, 1,   p‑Akt↑, 3,   CREB↑, 1,   p‑CREB↑, 3,   ERK↓, 6,   ERK↑, 4,   p‑ERK↓, 2,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   Hippo↑, 1,   IKKα↓, 1,   IKKα↑, 1,   IκB?, 1,   JAK2↓, 2,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 9,   JNK↑, 1,   p‑JNK↓, 5,   MAPK↓, 12,   MAPK↑, 2,   MAPK↝, 1,   p‑MAPK↓, 1,   mTOR↓, 4,   mTOR↑, 6,   p‑mTOR↓, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PFKFB2↓, 1,   PI3K↓, 4,   PI3K↑, 13,   p‑PI3K↓, 1,   PKCδ↑, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 2,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF4↓, 2,   cJun↓, 1,   cMyc↓, 1,   FOXO1↝, 1,   FOXO3?, 1,   FOXO3↑, 3,   HDAC↓, 1,   miR-34a↓, 1,   other↓, 6,   other↑, 14,   other↝, 5,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 4,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 5,   HSPs↑, 1,   PERK↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 1,   p62↑, 4,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 14,   P53↓, 2,   PARP↓, 1,   PARP1↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↑, 1,   Diff↝, 1,   IGF-1↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 1,   NOTCH1↑, 1,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 3,   AP-1↑, 1,   BACH1↓, 1,   Ca+2↓, 10,   Ca+2↑, 1,   Ca+2↝, 1,   i-Ca+2↓, 1,   Cartilage↑, 2,   COL1↓, 2,   COL1↑, 2,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 7,   MMPs↓, 5,   MUC1↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   serineP↓, 1,   TGF-β↓, 5,   TGF-β↑, 3,   TGF-β1↓, 2,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 2,   TXNIP↑, 1,   Vim↓, 2,   α-SMA↓, 6,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 2,   LOX1↓, 2,   NO↓, 33,   NO↑, 6,   TXA2↓, 1,   VCAM-1↓, 5,   VEGF↓, 4,   VEGF↑, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 2,   BBB↑, 19,   BBB↝, 1,   CLDN1↓, 1,   GastroP↑, 5,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 6,   MMP↓, 2,   MMP↑, 24,   OCLN↓, 1,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 3,   TRPM7⇅, 1,   TRPV3↑, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2↓, 58,   COX2/PTGS2↑, 2,   CXCc↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 6,   IFN-γ↓, 5,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 10,   IL10↑, 14,   IL12↓, 4,   IL12↑, 1,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 70,   IL1β↑, 1,   IL2↓, 4,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL4↓, 8,   IL4↑, 4,   IL5↓, 2,   IL6↓, 64,   IL6↑, 5,   IL8↓, 7,   IL8↑, 1,   Imm↑, 10,   INF-γ↓, 2,   Inflam↓, 148,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MyD88↓, 2,   NeuroI↓, 4,   NF-kB↓, 78,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 15,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 19,   PGE2↑, 3,   RAGE↓, 4,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 19,   TNF-α↓, 95,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 2,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 6,   Ach↑, 5,   AChE↓, 40,   AChE↑, 1,   ADAM10↑, 2,   BChE↓, 8,   BDNF↑, 26,   BDNF∅, 1,   ChAT↑, 5,   EndoR↑, 1,   GABA↓, 2,   GABA↑, 3,   MAOA↓, 5,   MAOB↓, 1,   monoA↓, 1,   monoA↑, 1,   NGF↑, 5,   PSD95↑, 2,   RELN↑, 1,   SNAP25↑, 2,   TPH1↓, 1,   TrkB↑, 4,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   APP↓, 6,   Aβ↓, 42,   Aβ42↓, 3,   BACE/β-secretase↓, 10,   PSEN1/PS1↓, 1,   tau↓, 8,   p‑tau↓, 10,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,   cortisol↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 4,   GR↝, 1,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 5,   testos↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 22,   BioAv↑, 50,   BioAv⇅, 1,   BioAv↝, 21,   BioEnh↑, 3,   ChemoSen↑, 1,   CompStab↑, 3,   CYP2D6↓, 1,   CYP2E1↓, 2,   CYP3A2↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose↝, 29,   eff↑, 21,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 6,   Half-Life↓, 1,   Half-Life↑, 2,   Half-Life↝, 8,   P-gp/ABCB1↓, 2,   P450↓, 2,   P450↑, 2,   selectivity↑, 1,   Synergy↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 35,   ALAT↑, 1,   ALAT∅, 1,   ALP↓, 14,   AST↓, 37,   AST↑, 1,   AST∅, 1,   BG↓, 4,   Bil↓, 1,   Bil↑, 1,   BloodF↑, 2,   BMD↑, 3,   BP↓, 11,   BP∅, 1,   BUN?, 1,   BUN↓, 5,   Calcium↑, 1,   creat↓, 10,   CRP↓, 7,   hs-CRP↓, 1,   IL6↓, 64,   IL6↑, 5,   LDH↓, 12,   LDH↑, 2,   Mag↑, 1,   NOS2↓, 2,   RAGE↓, 4,   SpO2↑, 1,   TG/TAG↓, 2,   Urea↓, 4,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll?, 1,   antiAll↑, 17,   AntiArt↑, 8,   AntiCan↑, 18,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↑, 25,   antiM↑, 1,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 3,   antiPy↑, 1,   AntiTum↑, 1,   ANXi↓, 1,   cardioP?, 1,   cardioP↑, 54,   CardioT↓, 1,   chemoP↑, 11,   chemoPv↑, 2,   ChemoSideEff↓, 1,   cognitive↓, 2,   cognitive↑, 53,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 58,   Learn↑, 6,   memory↑, 50,   Mood↑, 1,   motorD↓, 1,   motorD↑, 10,   Mucositis↓, 2,   neuroP?, 1,   neuroP↑, 110,   NP/CIPN↓, 1,   Obesity↓, 10,   OS↑, 2,   Pain↓, 7,   QoL↑, 2,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 26,   Risk↓, 3,   Sleep↑, 3,   Strength↑, 3,   Stroke↓, 9,   toxicity?, 2,   toxicity↓, 23,   toxicity↑, 4,   toxicity↝, 6,   toxicity∅, 5,   Weight↓, 2,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 9,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 12,   AntiFungal↑, 4,   AntiP↑, 2,   AntiViral↑, 8,   Bacteria↓, 17,   Diar↓, 3,   GutMicro↑, 26,   Inf↓, 1,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 1,   Ingr↝, 4,   Phen↑, 1,   QC↑, 1,  
Total Targets: 602

Scientific Paper Hit Count for: Catalase, Catalase
18 Thymoquinone
13 Magnetic Fields
13 Curcumin
12 Hydrogen Gas
11 Luteolin
10 Silver-NanoParticles
10 Lycopene
9 Melatonin
9 Quercetin
8 Resveratrol
8 Carvacrol
8 Ferulic acid
7 Boron
7 Chrysin
7 Silymarin (Milk Thistle) silibinin
6 Selenium NanoParticles
6 Moringa oleifera
6 Rosmarinic acid
5 Apigenin (mainly Parsley)
5 Propolis -bee glue
5 Crocetin
5 EGCG (Epigallocatechin Gallate)
5 Hyperoside
4 Alpha-Lipoic-Acid
4 Radiotherapy/Radiation
4 Betulinic acid
4 Chlorogenic acid
4 Chemotherapy
4 Eugenol
4 Gallic acid
4 Morin
4 Sulforaphane (mainly Broccoli)
4 Urolithin
4 Vitamin C (Ascorbic Acid)
3 Ascorbyl Palmitate
3 Capsaicin
3 doxorubicin
3 D-limonene
3 Fisetin
3 Isoliquiritigenin
3 Licorice
3 Pterostilbene
3 Shikonin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 Selenium
2 Boswellia (frankincense)
2 α-Bisabolol / Chamomile oil
2 buckwheat sprouts
2 Thymol-Thymus vulgaris
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Carvone
2 Copper and Cu NanoParticles
2 Date Fruit Extract
2 Sesame seeds and Oil
2 Shilajit/Fulvic Acid
2 Cisplatin
2 Graviola
2 HydroxyCitric Acid
2 Hibiscus sabdariffa
2 Honokiol
2 isoquercitrin
2 Kaempferol
2 Magnolol
2 Matrine
2 Magnetic Field Rotating
2 Methylsulfonylmethane
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Piperine
2 Piperlongumine
2 salinomycin
2 Selenite (Sodium)
1 1,8-Cineole
1 5-Aminolevulinic acid
1 Annona atemoya Seed Extract
1 Photodynamic Therapy
1 Allicin (mainly Garlic)
1 Andrographis
1 Astaxanthin
1 Aloe anthraquinones
1 Beta-Caryophyllene
1 Bacopa monnieri
1 Bromelain
1 Caffeic acid
1 chaetocin
1 Ginkgo biloba-EGb 761
1 Emodin
1 Exercise
1 Formononetin
1 Fucoidan
1 Germanium inorganic
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Zinc
1 Germacranolide sesquiterpene lactone
1 Orlistat
1 Hydroxycinnamic-acid
1 Isobavachalcone
1 Inositol
1 Butein
1 Scopoletin
1 isoorientin
1 Ivermectin
1 Juglone
1 Linalool
1 Mung Bean Sprouts
1 Methyl Jasmonate
1 Metformin
1 Magnesium
1 Lemon Balm/Melissa officinalis
1 Oleuropein
1 HydroxyTyrosol
1 Propyl gallate
1 Parthenolide
1 Oxygen, Hyperbaric
1 Taurine
1 5-fluorouracil
1 Turmerones
1 Ursolic acid
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:46  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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