TumMeta Cancer Research Results

TumMeta, Cancer Metastasis: Click to Expand ⟱
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Cancer metastasis is the process by which cancer cells spread from the original (primary) tumor to other parts of the body, forming new (secondary) tumors. This occurs when cancer cells invade surrounding tissues, enter the bloodstream or lymphatic system, and travel to distant organs or tissues.


Scientific Papers found: Click to Expand⟱
8648- MBZ,    Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature
- Review, Var, NA
angioG↓, MMPs↓, MDR1↓, TubPol↓, RadioS?, ChemoSen?, TumCG↓, TumMeta?, OS↑, BioAv↓, BioAv↑, BBB↑, mitA↑, HH↓, Shh↓, Synergy↑, Gli1↓, PTCH2↓, XIAP↓, cl‑PARP↑, Casp3↑, BRAF↓, MEK↓, SYN1↑, Cyt‑c↑, TumVol↓, VEGFR2/KDR/Flk1↓, VEGF↓, VCAM-1↓, DYRK1B↓, QoL↑, Dose↝,
8820- MCP,    Effect of pectasol-c modified citrus pectin (P-MCP) treatment (tx) on PSA dynamics in non- metastatic biochemically relapsed prostate cancer (BRPC) patients (pts): Primary outcome analysis of a prospective phase II study.
- Trial, Pca, NA
toxicity↝, SD↝, PSA↓, PSADT↓, TumMeta∅,
8823- MCP,    Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model
- in-vivo, CRC, CT26
TumMeta↓, Gal-3↓, TumVol↓, Dose↝,
8825- MCP,    modified citrus pectin supplement
- Review, Var, NA
Gal-3↓, *antiOx↑, Imm↑, IronCh↑, TumMeta↓, TumCP↓, PSA↓, NK cell↑, T-Cell↑,
8622- MCT,    Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model
- vitro+vivo, HCC, NA
AntiTum↑, HGF/c-Met↓, TumCG↓, TumMeta↓,
3464- MF,    Progressive Study on the Non-thermal Effects of Magnetic Field Therapy in Oncology
- Review, Var, NA
AntiTum↑, TumCG↓, TumCCA↑, Apoptosis↑, TumAuto↑, Diff↑, angioG↓, TumMeta↓, EPR↑, ChemoSen↑, ROS↑, DNAdam↑, P53↑, Akt↓, MAPK↑, Casp9↑, VEGFR2/KDR/Flk1↓, P-gp/ABCB1↓,
3500- MF,    Moderate Static Magnet Fields Suppress Ovarian Cancer Metastasis via ROS-Mediated Oxidative Stress
- in-vitro, Ovarian, SKOV3
ROS↑, CSCs↓, CD44↓, SOX2↓, cMyc↓, TumMeta↓, TumCI↓, TumCMig↓, CD133↓, Nanog↓,
517- MF,  Rad,    Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasis
- in-vivo, BC, MDA-MB-231
TumMeta↓, TumCG↓,
5242- MFrot,    Rotating magnetic field downregulating type XI collagen to suppress triple-negative breast cancer metastasis by inactivating the ITGB1/FAK/YAP signaling pathway
- in-vitro, BC, NA
TumCI↓, COL11A1↓, TumCG↓, TumMeta↓, ITGB1↓, FAK↓, YAP/TEAD↓, Dose↝,
205- MFrot,  MF,    Intermittent F-actin Perturbations by Magnetic Fields Inhibit Breast Cancer Metastasis
- vitro+vivo, BC, MDA-MB-231
OS↑, F-actin↓, TumCI↓, TumCMig↓, Rho↓, selectivity↑, TumMeta↓,
200- MFrot,  MF,    Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice
- in-vivo, BC, MDA-MB-231 - in-vivo, BC, MCF7
ALAT↓, TumVol↓, TumCCA↑, TumCG↓, TumMeta↓, Imm↑, P53↑, ALAT↓, AST↓,
198- MFrot,  MF,    Biological effects of rotating magnetic field: A review from 1969 to 2021
- Review, Var, NA
AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,
8460- Mg,    Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy
- vitro+vivo, Var, NA
TRPM7↑, TumAuto↓, TumCD↑, TumMeta↓, TumCG?, Apoptosis↑, TumCCA↑, ROS↑, other?,
8662- MLT,    Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis
- vitro+vivo, Bladder, 5637 - in-vitro, CRC, T24/HTB-9 - in-vitro, HNSCC, UM-SCC-1
Glycolysis↓, ENO1↓, ROS↑, TumCP↓, TumMeta↓, TumCCA↑, Casp3↑, BIM↑, Bcl-2↓, γH2AX↑, EMT↓, N-cadherin↓, MMP9↓, Snail↓, Akt↓, eff↓, TumVol↓, PPARγ↓,
8684- MLT,    Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress
- in-vivo, SCC, CAL27 - in-vivo, Tong, SCC9
TumCP↓, TumCG↓, ROS↑, Apoptosis↑, TumCMig↓, TumMeta↓,
8686- MLT,  CAP,    Non-thermal plasma-treated melatonin inhibits the biological activity of HCC cells by increasing intracellular ROS levels and reducing RRM2 expression
- in-vitro, Liver, HepG2 - in-vitro, Liver, HUH7
Synergy↑, TumCI↓, TumCMig↓, Apoptosis↑, TumCP↓, TumMeta↓, radioP↑, ROS↑, RRM2↓,
8682- MLT,    Melatonin suppresses tumor proliferation and metastasis by targeting GATA2 in endometrial cancer
- vitro+vivo, EC, NA
GATA2↑, TumCP↓, TumMeta↓,
1779- MLT,    Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review
- Review, BC, NA
QoL↑, OS↑, Dose∅, antiOx↑, ROS↑, SOD↑, Catalase↑, GPx↑, Risk↓, NK cell↑, IL1β↓, IL6↓, TNF-α↓, radioP↑, chemoP↑, TumVol↓, TumMeta↓, angioG↓, ChemoSen↑, eff↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
8917- MO,    Harnessing Moringa oleifera for Immune Modulation in Cancer: Molecular Mechanisms and Therapeutic Potential
- Review, Var, NA
*Ingr↝, *Inflam↓, *TNF-α↓, *IL1β↓, *iNOS↓, *PGE2↓, *PPARγ↑, pol-TregCell↓, NK cell↑, CD8+↑, CD4+↑, *GutMicro↑, Imm↑, TumCMig↓, TumMeta↓, Synergy↑, *toxicity↓, Apoptosis↑, TumCCA↑,
8765- MSM,    Combination of AG490, a Jak2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway
- vitro+vivo, Bladder, NA
*toxicity↓, tumCV↓, TumCMig↓, TumCG↓, STAT3↓, STAT5↓, IGF-1R↓, VEGF↓, VEGFR2/KDR/Flk1↓, TumMeta↓, Synergy↑,
8943- MushCha,    Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice
- in-vivo, Lung, NA
AntiTum↑, TumVol↓, Dose↝, Weight↓, TumMeta↓,
2938- NAD,    NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling
- in-vivo, BC, NA
TumMeta↓, SIRT1↑,
5598- NaHCO3,    Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
- in-vivo, BC, MDA-MB-231
e-pH↑, TumMeta↓, TumCG⇅, Dose↑,
5616- NaHCO3,  DCA,    Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer
- vitro+vivo, BC, MDA-MB-231
OS↑, e-pH↑, TumMeta↓, eff↝, TumCG↝,
5612- NaHCO3,  immuno,    Neutralization of tumor acidity improves anti-tumor responses to immunotherapies
- vitro+vivo, Var, B16-F10
Imm↑, eff↑, e-pH↑, TumCG↓, TumMeta↓, eff↑,
5608- NaHCO3,    Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism
- Study, Var, NA
TumCG↓, TumMeta↓, e-pH↑, Pyro↑, Imm↑, Na+↑,
5607- NaHCO3,    Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review
- Review, Var, NA
AntiCan↑, e-pH↑, TumMeta↓, TumCI↓, TumCG↓, CD8+↑, NK cell↑, Remission↑, Synergy↑, ChemoSen↑, ChemoSen↓,
5604- NaHCO3,    Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity
- vitro+vivo, Melanoma, B16-BL6 - in-vitro, BC, 4T1
eff↑, eff↑, TumMeta↓, pH↑, CaMKII ↑, CREB↑, PGC-1α↑, AntiTum↑, Imm↑, CD8+↑, TAMS↑,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
6489- Nimb,    Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model
- in-vivo, Pca, DU145 - in-vivo, Pca, LNCaP
tumCV↓, Apoptosis↑, TumCI↓, TumCMig↓, STAT3↓, ROS↑, TumCG↓, TumMeta↓, TumCCA↑, DNAdam↑, Casp3↑, Casp7↑, cl‑PARP↑, p‑STAT3↓, IL6↓, GSR↓,
6488- Nimb,    Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation
- in-vitro, BC, NA
TumCP↓, AntiTum↑, TumMeta↓, selectivity↑,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4970- Nimb,    Insights into Nimbolide molecular crosstalk and its anticancer properties
- Review, Var, NA
chemoPv↑, Apoptosis↑, TumCP↓, TumCD↑, TumMeta↓, angioG↓,
4971- Nimb,    Nimbolide, a Neem Limonoid, Is a Promising Candidate for the Anticancer Drug Arsenal
- Review, Var, NA
TumCP↓, Apoptosis↓, TumCI↓, angioG↓, TumMeta↓, Inflam↓,
4974- Nimb,    Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma
- in-vitro, OS, NA
Apoptosis↑, ER Stress↑, mtDam↑, ROS↑, Casp↑, TumCMig↓, TumMeta↓,
4977- Nimb,    Nimbolide Inhibits SOD2 to Control Pancreatic Ductal Adenocarcinoma Growth and Metastasis
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, PANC1
SOD2↑, TumCG↓, TumMeta↓, ROS↑, Apoptosis↑, PI3K↓, Akt↓, EMT↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, Bcl-2↓,
4628- OLE,    Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases
- in-vitro, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumCI↓, TumMeta↓,
8425- OM,    Anti-metastatic and anti-tumor growth effects of Origanum majorana on highly metastatic human breast cancer cells: inhibition of NFκB signaling and reduction of nitric oxide production
- vitro+vivo, BC, MDA-MB-231
TumCCA↑, Apoptosis↑, E-cadherin↑, TumCMig↓, MMP2↓, MMP9↓, uPAR↓, ICAM-1↓, VEGF↓, p‑IκB↓, NF-kB↓, NO↓, TumCG↓, TumMeta↓,
8435- OM,  Aroma,    Memory-Enhancing Effects of Origanum majorana Essential Oil in an Alzheimer's Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study
- in-vivo, AD, NA
*Dose?, *antiOx↑, *BDNF↑, *cognitive↑, *AntiViral↑, *AChE↝, *TumMeta↓, *TumCG↓, *Ingr↝, *DNAdam↓, *ROS↓, *MDA↓, *memory↑,
8443- OM,    Natural Remedies for Gut Health: The Role of Plant Extracts in Combating Inflammatory Bowel Disease and Colon Cancer
- Review, IBD, NA - Review, Colon, NA
AntiCan↑, TumAuto↑, AIF↑, tumCV↓, TumCCA↑, *NF-kB?, ROS↑, TumCP↓, TumMeta↓, P53↑, BAX↑,
8452- OM,    Sweet Marjoram: A Review of Ethnopharmacology, Phytochemistry, and Biological Activities
- Review, Nor, NA
*hepatoP↑, *cardioP↑, *AntiAg↑, *GastroP↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *TumMeta↓, *AntiTum↑, *AChE↓, *Ingr↝, *antiOx↑, Apoptosis↑, P53↑, Bcl-2↓, E-cadherin↑, MMP2↓, MMP9↓, TumMeta↓, *NO↓, *lipid-P↓,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP/DDIT3↑, AR↓, other?,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, ChemoSen↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4918- PEITC,    Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
- Review, Var, NA
Apoptosis↑, TumCP↓, angioG↓, TumMeta↓, NF-kB↓, Akt↓, MAPK↓, *BioAv↓, ROS↑, lipid-P↑, AIF↑, Cyt‑c↑, DR4↑, DR5↑, TumCCA↑, JAK↓, STAT3↓, MMP2↓, MMP9↓, PKCδ↓, Hif1a↓, JNK↓, Mcl-1↓, COX2/PTGS2↓, MMP↓, Casp3↑, ChemoSen↑, *BioAv↓, Half-Life↓,
4932- PEITC,    Pharmacokinetics and Pharmacodynamics of Phenethyl Isothiocyanate: Implications in Breast Cancer Prevention
- Review, BC, NA
TumCCA↑, ROS↑, GSH↓, ERα/ESR1↓, TumMeta↓, angioG↓,
4933- PEITC,    Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification
- vitro+vivo, Lung, H1299 - vitro+vivo, SCC, H226
AntiCan↓, TumCP↓, TumMeta↓, ChemoSen↑, tumCV↓, TumCI↓, TumCMig↓, FTO↓, TLE1↓, Akt↓, NF-kB↓,
5187- PEITC,    Phenethyl Isothiocyanate Inhibits Migration and Invasion of Human Gastric Cancer AGS Cells through Suppressing MAPK and NF-κB Signal Pathways
- in-vitro, GC, AGS
TumMeta↓, ERK↓, MKK7↓, PKCδ↓, Rho↓, uPA↓, MMP2↓, MMP9↓, RAS↓, VEGF↓, FAK↓, iNOS↓, COX2/PTGS2↓, TumCP↓,

Showing Research Papers: 251 to 300 of 371
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 371

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 16,   antiOx⇅, 1,   Catalase↑, 3,   Fenton↑, 2,   GPx↑, 3,   GPx1↓, 1,   GPx4↓, 5,   GSH↓, 20,   GSH↑, 4,   GSH/GSSG↓, 1,   GSR↓, 2,   GSR↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 3,   HO-1↑, 9,   Iron↑, 2,   lipid-P↓, 2,   lipid-P↑, 9,   MDA↓, 2,   MDA↑, 5,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 1,   NRF2↓, 12,   NRF2↑, 10,   NRF2↝, 1,   Prx↓, 2,   Prx4↑, 1,   ox-PrxI↑, 1,   PrxII↓, 1,   RNS↑, 1,   ROS↓, 17,   ROS↑, 140,   ROS⇅, 4,   ROS↝, 1,   i-ROS↓, 1,   mt-ROS↑, 2,   SOD↓, 1,   SOD↑, 6,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 3,   Thiols↓, 1,   Trx↓, 1,   TrxR↓, 6,   TrxR1↓, 1,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh∅, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC25↓, 4,   compI↓, 1,   EGF↓, 1,   ETC↓, 5,   mitResp↓, 3,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↑, 9,   OCR↓, 5,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   PDH↝, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 2,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 2,   ACC↑, 1,   ALAT↓, 3,   AMPK?, 1,   AMPK↓, 1,   AMPK↑, 14,   p‑AMPK↑, 1,   ATP↓, 14,   ATP↑, 1,   mt-ATP↓, 1,   Buty↑, 1,   CAIX/CA9↑, 1,   ECAR↓, 3,   ENO1↓, 1,   FAO↓, 1,   FASN↓, 5,   G6PD↓, 3,   GAPDH↓, 1,   GLS↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 12,   GlutMet↓, 1,   Glycolysis↓, 31,   GSK‐3β↓, 11,   GSK‐3β↑, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   Histones↑, 1,   HK2↓, 13,   HMG-CoA↓, 1,   lactateProd↓, 10,   lactateProd↑, 1,   LDHA↓, 6,   LDL↓, 3,   NADPH↓, 3,   NADPH↑, 1,   PA↑, 1,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 10,   PPP↓, 1,   Pyruv↓, 1,   SCD1↓, 1,   SCFAs↑, 1,   SIRT1↓, 5,   SIRT1↑, 8,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 7,   Apoptosis↑, 154,   m-Apoptosis↑, 1,   mt-Apoptosis↑, 1,   ASC↑, 1,   ASK1↑, 1,   BAD↓, 3,   BAD↑, 2,   Bak↑, 4,   BAX↓, 1,   BAX↑, 57,   Bax:Bcl2↑, 11,   Bcl-2↓, 65,   Bcl-2↑, 4,   Bcl-xL↓, 18,   BID↓, 1,   BID↑, 3,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 6,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 24,   Casp↝, 1,   Casp∅, 1,   cl‑Casp↑, 1,   Casp1↓, 2,   Casp1↑, 1,   Casp12↑, 1,   Casp3↓, 3,   Casp3↑, 76,   cl‑Casp3↑, 7,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 13,   cl‑Casp7↑, 2,   Casp8↑, 11,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↑, 44,   cl‑Casp9↑, 3,   proCasp9↑, 1,   cFLIP↓, 2,   Cupro↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 46,   Cyt‑c↝, 1,   Diablo↑, 6,   DR5↑, 10,   Endon↑, 1,   FADD↑, 5,   Fas↓, 1,   Fas↑, 10,   FasL↑, 4,   Ferroptosis↑, 11,   GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 5,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 8,   Mcl-1↓, 14,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 6,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 1,   p38↓, 4,   p38↑, 11,   p‑p38↓, 3,   p‑p38↑, 2,   Paraptosis↑, 1,   PUMA↑, 2,   Pyro↑, 3,   survivin↓, 37,   TRAIL↑, 1,   TumCD↑, 14,   TumCD∅, 1,   XIAP↓, 13,   YAP/TEAD↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 111,   Akt↑, 1,   p‑Akt↓, 16,   p‑Akt↑, 1,   AKT1↓, 3,   Akt2↓, 1,   BRAF↓, 1,   CaMKII ↑, 1,   CIP2A↓, 1,   CK2↓, 3,   cMET↓, 2,   CREB↓, 1,   CREB↑, 1,   cSrc↓, 2,   DDIT4↑, 1,   DYRK1B↓, 1,   EF-1α↓, 1,   EGFR↓, 27,   p‑EGFR↓, 1,   ERK↓, 30,   ERK↑, 4,   ERK↝, 1,   p‑ERK↓, 8,   p‑ERK↑, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   Hippo↝, 1,   IGF-1R↓, 4,   IGFR↓, 1,   IKKα↓, 5,   IP6K1↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 4,   JAK1↓, 3,   JAK2↓, 8,   JNK↓, 4,   JNK↑, 13,   p‑JNK↓, 3,   p‑JNK↑, 2,   MAPK?, 1,   MAPK↓, 34,   MAPK↑, 7,   MARK4↓, 1,   MEK↓, 3,   mTOR↓, 50,   mTOR↑, 1,   p‑mTOR↓, 3,   mTORC2↓, 1,   p42↑, 1,   P70S6K↓, 2,   PI3K↓, 78,   p‑PI3K↓, 2,   PKA↓, 1,   PKCδ↓, 7,   PTEN↓, 1,   PTEN↑, 17,   p‑PTEN↓, 1,   Raf↓, 2,   c-Raf↓, 1,   RAS↓, 6,   SHP1↑, 2,   Sp1/3/4↓, 10,   Src↓, 2,   STAT↓, 4,   STAT3↓, 51,   STAT3↑, 1,   STAT3↝, 1,   p‑STAT3↓, 7,   STAT5↓, 2,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↓, 1,   ATF4↑, 4,   ATF4↝, 1,   CBP↓, 3,   ChrMod↑, 1,   circNAV3↓, 1,   cJun↓, 3,   cJun↑, 2,   cMyc↓, 23,   cMyc↑, 1,   DNMT1↓, 5,   DNMT3A↓, 2,   DNMTs↓, 5,   EZH2↓, 2,   FOXM1↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   GATA2↑, 1,   H3↑, 1,   ac‑H3↑, 2,   H4↑, 2,   ac‑H4↑, 2,   HATs↓, 6,   HATs↑, 2,   HDAC↓, 16,   HDAC1↓, 5,   HDAC2↓, 2,   HDAC4↓, 3,   HDAC8↓, 1,   HES1↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-125b↝, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 1,   miR-200b↑, 1,   miR-205↑, 1,   miR-21↓, 4,   miR-218↑, 1,   miR-224↓, 1,   miR-29b↑, 2,   miR-30a-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   miR-422a↑, 1,   miR-590-3p↑, 1,   Myc↓, 4,   NDRG1↑, 2,   OCT4↓, 9,   other?, 3,   other↓, 1,   other↑, 8,   other↝, 12,   PCAF↓, 1,   SD↝, 1,   SOX2↓, 7,   SOX4↓, 1,   SOX4↑, 1,   TCF-4↓, 1,   TLE1↓, 1,   tumCV↓, 26,   tumCV∅, 1,   YMcells↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 11,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↓, 2,   ER Stress↑, 23,   GRP78/BiP↓, 2,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 3,   e-HSP70/HSPA5↓, 1,   HSP90↓, 8,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 2,   PERK↑, 3,   Proteasome↓, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   ATG7↑, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 3,   LC3B-II↑, 1,   LC3II↑, 10,   LC3s↓, 1,   LC3s↑, 1,   p62↓, 4,   p62↑, 1,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↓, 1,   TumAuto↑, 34,   TumAuto↝, 1,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 2,   BRCA1↑, 2,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 38,   DNArepair↓, 2,   DNArepair↑, 1,   m-FAM72A↓, 1,   G9a↓, 1,   hTERT/TERT↓, 5,   P53?, 1,   P53↓, 2,   P53↑, 59,   P53↝, 2,   p‑P53↑, 3,   PARP↑, 5,   cl‑PARP↓, 1,   cl‑PARP↑, 38,   PARP1↑, 3,   PCNA↓, 20,   POLD1↓, 1,   SIRT6↓, 1,   Telomerase↓, 5,   TOP1↓, 5,   TOP2↓, 4,   TP53↑, 1,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 5,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK2↓, 21,   CDK2↑, 1,   CDK4↓, 29,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 9,   CDK6↑, 1,   CDK7↓, 1,   CHK1↓, 2,   CHK1↑, 1,   Chk2↓, 2,   Chk2↑, 2,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 12,   cycD1/CCND1↓, 47,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 11,   E2Fs↓, 5,   E2Fs↑, 1,   GADD45A↓, 1,   Ki-67↓, 22,   Ki-67↑, 1,   MAD↓, 1,   mitA↑, 2,   P21?, 1,   P21↓, 3,   P21↑, 40,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 15,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   RRM2↓, 1,   Securin↓, 1,   TubPol↓, 1,   TumCCA?, 1,   TumCCA↓, 8,   TumCCA↑, 132,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 8,   ALDH1A1↓, 1,   AXIN1↑, 1,   Axin2↑, 1,   BMI1↓, 1,   BMPs↑, 2,   CD133↓, 5,   CD133↑, 1,   CD24↓, 3,   CD34↓, 2,   cFos↓, 5,   cMYB↓, 1,   CSCs↓, 35,   CSCsMark↓, 1,   Diff↑, 4,   Gli1↓, 7,   HH↓, 7,   HMGCR↓, 1,   IGF-1↓, 5,   IGF-2↓, 1,   IGFBP3↑, 2,   Jun↓, 1,   Ki-67↓, 22,   Ki-67↑, 1,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 7,   Nestin↓, 1,   NOTCH↓, 9,   NOTCH1↓, 9,   NOTCH1↑, 2,   NOTCH1↝, 1,   NOTCH3↓, 2,   p300↓, 3,   Piezo1↑, 1,   PTCH1↓, 1,   PTCH2↓, 1,   SCF↓, 1,   Shh↓, 3,   Smo↓, 2,   STAT1↓, 1,   TumCG?, 1,   TumCG↓, 86,   TumCG↑, 4,   TumCG⇅, 1,   TumCG↝, 1,   TumCG∅, 2,   TumCP↓, 133,   TumCP↑, 4,   WDR72↓, 1,   Wnt↓, 29,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   annexin II↓, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 10,   AP-1↝, 1,   ASAP2↓, 1,   AXL↓, 2,   BACH1↑, 1,   Ca+2↓, 2,   Ca+2↑, 14,   CAFs/TAFs↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   Cdc42↑, 1,   COL11A1↓, 1,   CTNNB1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 45,   EMT↓, 80,   EMT↑, 2,   EpCAM↓, 3,   F-actin↓, 2,   FAK↓, 15,   p‑FAK↓, 4,   p‑FAK↑, 1,   Fibronectin↓, 4,   GIT1↓, 1,   GLI2↓, 1,   ITGB1↓, 4,   ITGB4↓, 2,   ITGB6↓, 1,   LAMs↓, 1,   LEF1↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP1↓, 5,   MMP13↓, 5,   MMP15↓, 1,   MMP16↓, 1,   MMP2↓, 76,   MMP3↓, 6,   MMP7↓, 4,   MMP9↓, 95,   MMP9↑, 3,   MMPs↓, 40,   MUC4↓, 2,   N-cadherin↓, 29,   Na+↑, 1,   NEDD9↓, 1,   p44↑, 1,   PAK1↓, 1,   pax↓, 1,   PDGF↓, 4,   Rac1↓, 2,   RECK↑, 2,   Rho↓, 7,   ROCK1↓, 4,   Slug↓, 14,   SMAD2↓, 3,   SMAD3↓, 4,   SMAD4↓, 2,   Snail?, 1,   Snail↓, 27,   TET1↑, 2,   TGF-β↓, 15,   TGF-β↑, 2,   TIMP1↑, 8,   TIMP2↑, 9,   TIMP3↑, 1,   pol-TregCell↓, 1,   TRIB3↑, 2,   TSP-1↑, 2,   TumCA↓, 1,   TumCI?, 1,   TumCI↓, 116,   TumCI↑, 3,   TumCMig↓, 64,   TumCMig↑, 2,   TumMeta?, 1,   TumMeta↓, 354,   TumMeta↑, 20,   TumMeta∅, 1,   TumPF↓, 1,   Twist↓, 18,   TXNIP↑, 1,   uPA↓, 12,   uPAR↓, 2,   Vim?, 1,   Vim↓, 34,   Vim↑, 1,   Zeb1↓, 15,   ZEB2↓, 3,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 40,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 125,   angioG↑, 5,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   ECM/TCF↓, 1,   eNOS↓, 1,   HIF-1↓, 5,   Hif1a↓, 41,   Hif1a↝, 1,   NO↓, 4,   TXA2↓, 2,   VCAM-1↓, 1,   VEGF↓, 76,   VEGFR1↓, 4,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 9,   CellMemb↑, 1,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN2↓, 1,   EPR↑, 9,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 1,   GLUT3↑, 1,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 59,   MPT↑, 2,   Na+↑, 1,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPM7↑, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↓, 1,   CD4+↑, 4,   CD44↓, 11,   CD8+↑, 6,   COX1↓, 5,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 1,   CXCL12↓, 1,   CXCL16↓, 1,   CXCR2↓, 2,   CXCR4↓, 13,   DCells↑, 1,   DR4↑, 5,   FOXP3↓, 1,   Gal-3↓, 2,   HMGB1↓, 2,   ICAM-1↓, 6,   IFN-γ↑, 1,   Igs↑, 1,   IL1↓, 4,   IL1↑, 1,   IL10↓, 3,   IL10↑, 1,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL6↓, 33,   IL6↑, 1,   IL8↓, 9,   IL8↑, 1,   Imm↑, 23,   Imm↝, 3,   Inflam↓, 30,   Inflam↝, 1,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 4,   MCT1↓, 1,   MDSCs↓, 1,   mPGES-1↓, 1,   NF-kB?, 1,   NF-kB↓, 100,   NF-kB↑, 2,   NF-kB↝, 1,   p‑NF-kB↑, 1,   NK cell↑, 7,   NLRP3↓, 5,   NLRP3↑, 1,   p65↓, 4,   p‑p65↓, 2,   PD-1↓, 2,   PD-L1↓, 3,   PGE2↓, 14,   PSA↓, 6,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 1,   TCF7/TCF1↓, 1,   Th1 response↑, 2,   TLR4↓, 2,   TLR4↝, 1,   TNF-α↓, 20,   TNF-α↑, 4,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   e-pH↑, 5,   TAMS↑, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

SYN1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 7,   ERα/ESR1↓, 1,   FGF21↓, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 38,   BioAv↑, 40,   BioAv↝, 8,   BioEnh↑, 2,   ChemoSen?, 1,   ChemoSen↓, 2,   ChemoSen↑, 119,   ChemoSen∅, 1,   CompStab?, 1,   CompStab↓, 3,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 2,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   DDS↑, 4,   Dose?, 2,   Dose↓, 2,   Dose↑, 3,   Dose↝, 37,   Dose∅, 6,   DrugR↓, 1,   eff↓, 15,   eff↑, 73,   eff↝, 4,   eff∅, 2,   GSTA1↑, 1,   GSTP1/GSTπ↓, 1,   Half-Life↓, 12,   Half-Life↑, 3,   Half-Life↝, 8,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 14,   P-gp/ABCB1↑, 1,   P-gp/ABCB1↝, 1,   P450↓, 2,   RadioS?, 1,   RadioS↑, 27,   selectivity?, 1,   selectivity↑, 45,   Synergy↑, 63,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 3,   ALP↓, 1,   AR↓, 7,   ascitic↓, 1,   AST↓, 2,   BP↓, 1,   BRAF↓, 1,   BRCA1↓, 2,   BRCA1↑, 2,   p‑BRCA1↑, 1,   CRP↓, 1,   CTC↓, 1,   EGFR↓, 27,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 2,   FOXM1↓, 2,   HER2/EBBR2↓, 7,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 5,   IL6↓, 33,   IL6↑, 1,   LDH↓, 2,   LDH↑, 2,   e-LDH↑, 1,   Maspin↑, 1,   Myc↓, 4,   NOS2↓, 1,   PD-L1↓, 3,   PSA↓, 6,   PSADT↓, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 2,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 39,   AntiCan∅, 1,   AntiDiabetic↑, 1,   antiNeop↑, 2,   AntiTum↑, 27,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 6,   CardioT↓, 1,   CardioT↑, 1,   chemoP↑, 21,   chemoPv↑, 20,   ChemoSideEff↓, 3,   fatigue↓, 1,   FTO↓, 1,   hepatoP↓, 1,   hepatoP↑, 6,   kidSt↓, 1,   neuroP↑, 7,   OS↑, 20,   OS⇅, 1,   Pain↓, 3,   Pin1↓, 1,   QoL↑, 8,   radioP↑, 11,   Remission↑, 3,   RenoP↑, 3,   Risk↓, 21,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 14,   toxicity↑, 4,   toxicity↝, 5,   toxicity∅, 1,   TumVol↓, 26,   TumVol∅, 1,   TumW↓, 7,   TumW∅, 1,   Weight↓, 1,   Weight↑, 2,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 2,   GutMicro↑, 6,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 2,   Ingr↝, 3,  
Total Targets: 883

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 50,   Catalase↑, 19,   GPx↑, 16,   GPx1↑, 2,   GSH↑, 12,   GSR↑, 4,   GSTs↑, 10,   H2O2↓, 1,   HDL↓, 1,   HO-1↑, 10,   Iron∅, 1,   Keap1↓, 1,   lipid-P↓, 18,   MDA↓, 6,   NRF2↑, 19,   RNS↓, 1,   ROS?, 2,   ROS↓, 50,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 19,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 1,   VitC↑, 1,   VitE↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↓, 1,   AMPK↑, 4,   ATP↓, 1,   cytoP450↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   LDL↓, 2,   lipidLev↓, 2,   NAD↓, 1,   NADPH↑, 1,   SIRT1↑, 2,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↓, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 7,   p38↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt2↓, 1,   CREB↑, 1,   ERK↑, 1,   IKKα↓, 1,   p‑JNK↓, 1,   MAPK↓, 3,   mTOR↓, 1,   PI3K↓, 1,   PKCδ↓, 2,   STAT↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   other↓, 2,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 5,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   GADD34↓, 1,   P21↓, 2,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,   TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 7,   AP-1↓, 2,   Ca+2↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 1,   MMP9↓, 1,   TGF-β↓, 1,   TumMeta↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 5,   TXA2↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   GastroP↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   MMP↓, 1,   MMP↑, 1,   MMP∅, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 13,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL17↓, 2,   IL1β↓, 8,   IL2↓, 1,   IL23↓, 1,   IL6?, 1,   IL6↓, 10,   Imm↓, 1,   Imm↑, 5,   Imm⇅, 1,   Inflam?, 1,   Inflam↓, 53,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB?, 1,   NF-kB↓, 15,   NLRP3↓, 3,   PGE2↓, 6,   TLR4↓, 1,   TLR4↑, 1,   TNF-α?, 1,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 6,   AChE↝, 1,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 2,   MAOA↓, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE/β-secretase↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   Estro↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 17,   BioAv↑, 23,   BioAv↝, 6,   BioEnh↑, 1,   CompStab↑, 2,   Dose?, 1,   Dose↝, 4,   eff↑, 3,   GSTA1↑, 2,   Half-Life↓, 3,   Half-Life↝, 2,   Half-Life∅, 1,   P450↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 3,   AST↓, 4,   BG↓, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 1,   CRP↓, 4,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 10,   IRes↑, 1,   LDH↓, 2,   TC↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 4,   antiAll↑, 2,   AntiArt↑, 4,   AntiCan↑, 11,   AntiDiabetic↑, 12,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP↑, 23,   chemoP↑, 4,   cognitive↓, 1,   cognitive↑, 7,   cough?, 1,   hepatoP↑, 18,   memory↑, 8,   Mood↑, 1,   motorD↓, 1,   neuroP↑, 32,   Obesity↓, 4,   OS↑, 1,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   SoreThr?, 1,   Stroke↓, 1,   toxicity↓, 19,   toxicity↑, 1,   toxicity↝, 6,   toxicity∅, 4,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiFungal↑, 3,   AntiP↑, 1,   AntiViral↑, 6,   Bacteria↓, 8,   GutMicro↑, 9,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↑, 3,   Ingr↝, 8,   Phen↑, 1,   QC↑, 1,  
Total Targets: 224

Scientific Paper Hit Count for: TumMeta, Cancer Metastasis
15 Curcumin
11 Thymoquinone
9 Nimbolide
8 Resveratrol
8 Eugenol
8 Quercetin
7 Melatonin
7 Pterostilbene
6 Chrysin
6 Magnetic Fields
6 Bicarbonate(Sodium)
5 Artemisinin
5 Aspirin
5 chitosan
5 Fisetin
5 Fucoidan
5 Gambogic Acid
5 Honokiol
5 phytic acid, Inositol hexakisphosphate
5 Kaempferol
5 Luteolin
5 Phenethyl isothiocyanate
4 Silver-NanoParticles
4 brusatol
4 Capsaicin
4 Celastrol
4 Flaxseed/Linseed
4 Inositol
4 Ivermectin
4 Magnetic Field Rotating
4 Marjoram (Origanum majorana)
4 Piperlongumine
4 Sulforaphane (mainly Broccoli)
4 Silymarin (Milk Thistle) silibinin
3 Baicalein
3 Berbamine
3 Biochanin A
3 Beta-Caryophyllene
3 Propolis -bee glue
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Chlorogenic acid
3 Cinnamon
3 Copper and Cu NanoParticles
3 Disulfiram
3 immunotherapy
3 EGCG (Epigallocatechin Gallate)
3 Garcinol
3 Ginkgetin
3 Licorice
3 Matrine
3 mebendazole
3 Modified Citrus Pectin
3 Ursolic acid
3 Vitamin C (Ascorbic Acid)
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Isovitexin
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Astaxanthin
2 Betulinic acid
2 Brucea javanica
2 Bromelain
2 Boswellia (frankincense)
2 Bruteridin(bergamot juice)
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Zinc
2 Coenzyme Q10
2 Vitamin K2
2 Cucurbitacin
2 Cyclopamine
2 Deguelin
2 D-limonene
2 Ellagic acid
2 Emodin
2 Sorafenib (brand name Nexavar)
2 Formononetin
2 Gallic acid
2 Ginkgo biloba
2 Isoliquiritigenin
2 isoorientin
2 Juglone
2 Licochalcone A
2 Lycopene
2 Magnolol
2 Radiotherapy/Radiation
2 Rosmarinic acid
2 Selenium
2 Selenium NanoParticles
2 Urolithin
1 1,8-Cineole
1 3-bromopyruvate
1 Astragalus
1 Ajoene (compound of Garlic)
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 almonertinib
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Atorvastatin
1 beta-glucans
1 Berberine
1 Bufalin/Huachansu
1 borneol
1 Butyrate
1 Carnosic acid
1 Caffeic acid
1 urea
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Docetaxel
1 Chocolate
1 Metformin
1 Boron
1 Carica papaya leaf extract
1 Crocetin
1 Dasatinib/Phyrago
1 Diclofenac
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 Dipyridamole
1 Ginkgo biloba-EGb 761
1 Electrical Pulses
1 Ferulic acid
1 ferumoxytol
1 Flaxseed Oil
1 Shilajit/Fulvic Acid
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Inulin Prebiotic
1 capecitabine
1 Gemcitabine (Gemzar)
1 isoflavones
1 isoquercitrin
1 itraconazole
1 Vitexin
1 Lapachol
1 VitK3,menadione
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Lutein
1 MCT oil
1 Magnesium
1 Moringa oleifera
1 Methylsulfonylmethane
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Dichloroacetate
1 Oleuropein
1 Aromatherapy
1 Phenylbutyrate
1 Piperine
1 Sanguinarine
1 Psoralidin
1 salinomycin
1 Sulfasalazine
1 Shikonin
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Whole Body Vibration
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:604  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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