cycD1/CCND1 Cancer Research Results

cycD1/CCND1, cyclin D1 pathway: Click to Expand ⟱
Source:
Type:
Also called CCND1 Gatekeeper of Cell-Cycle Commitment
The main function of cyclin D1 is to maintain cell cycle and to promote cell proliferation. Cyclin D1 is a key regulatory protein involved in the cell cycle, particularly in the transition from the G1 phase to the S phase. It is part of the cyclin-dependent kinase (CDK) complex, where it binds to CDK4 or CDK6 to promote cell cycle progression.
Cyclin D1 is crucial for the regulation of the cell cycle. Overexpression or dysregulation of cyclin D1 can lead to uncontrolled cell proliferation, a hallmark of cancer.
Cyclin D1 is often found to be overexpressed in various cancers.
Cyclin D1 can interact with tumor suppressor proteins, such as retinoblastoma (Rb). When cyclin D1 is overexpressed, it can lead to the phosphorylation and inactivation of Rb, releasing E2F transcription factors that promote the expression of genes required for DNA synthesis and cell cycle progression.
Cyclin D1 is influenced by various signaling pathways, including the PI3K/Akt and MAPK pathways, which are often activated in cancer.
In some cancers, high levels of cyclin D1 expression have been associated with poor prognosis, making it a potential biomarker for cancer progression and treatment response.
Scientific Papers found: Click to Expand⟱
4778- Lyco,    Lycopene exerts cytotoxic effects by mitochondrial reactive oxygen species–induced apoptosis in glioblastoma multiforme
- in-vitro, GBM, GBM8401
BBB↑, Apoptosis↑, TumCP↑, P53↑, CycB/CCNB1↓, cycD1/CCND1↓, TumCCA↓, mt-ROS↑, TumCG↓,
4780- Lyco,    Potential inhibitory effect of lycopene on prostate cancer
- Review, Pca, NA
TumCP↓, TumCCA↑, Apoptosis↑, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *Ca+2↝, *antiOx↑, *AntiCan↑, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *TNF-α↓, NF-kB↓, DNAdam↓, PSA↓, P53↓, cycD1/CCND1↓, NRF2↓, Akt2↓, PPARγ↓,
4784- Lyco,    Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives
- Review, Diabetic, NA - Review, CardioV, NA
*antiOx↑, *IL8↓, *IL6↓, *IL1↓, *NF-kB↓, Inflam↓, cycD1/CCND1↓, MMP2↓, MMP9↓, Bcl-2↓, NF-kB↓, *Nrf1↑, *antiOx↑, *BDNF↑, *neuroP↑, *cardioP↑, ROS↑, Dose↝,
4786- Lyco,    Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MCF7 - in-vitro, BC, SkBr3
TumCP↓, TumCCA↑, cl‑PARP↑, ERK↑, cycD1/CCND1↓, P21↓, p‑Akt↓, mTOR↓, BAX↑, AntiCan↑, Risk↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↑, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27/CDKN1B↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,
4795- Lyco,    Updates on the Anticancer Profile of Lycopene and its Probable Mechanism against Breast and Gynecological Cancer
- Review, BC, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↝, BAX↝, cycD1/CCND1↓, ERK↓, Akt↓, STAT3↓, NRF2↝, NF-kB↓, ITGB1↓, ITGA5↓, FAK↓, MMP9↓, EMT↓,
8519- MAG,    Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway
- vitro+vivo, Gall, NA
TumCG?, TumCCA↑, mt-Apoptosis↑, P53↑, P21↑, cycD1/CCND1↓, CDC25↓, CDK2↓, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, cl‑PARP↑,
8518- MAG,    Magnolol suppresses the proliferation and invasion of cholangiocarcinoma cells via inhibiting the NF-κB signaling pathway
- in-vitro, CCA, NA
TumCG↓, TumCMig↓, TumCI↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, p‑IκB↓, p‑p65↓, NF-kB↓,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4516- MAG,    Magnolol Induces Apoptosis and Suppresses Immune Evasion in Non-small Cell Lung Cancer Xenograft Models
- in-vivo, NSCLC, NA
selectivity↑, Apoptosis↑, TumCCA↑, Casp3↑, cycD1/CCND1↓, CDK4↓, VEGF↓, FOXP3↓, IDO1↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, Synergy↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8822- MCP,    Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3
- vitro+vivo, CRC, T24/HTB-9 - in-vitro, Bladder, J82
TumCCA↑, cycD1/CCND1↓, p‑cDC2↓, Casp3↑, cl‑Casp3↑, cl‑PARP↑, Gal-3↓, Akt↓, TumCG↓, Ki-67↓, Dose⇅,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
5800- MET,    Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
- Review, Var, NA
ChemoSen↑, RadioS↑, Imm↑, *AntiDiabetic↑, *AMPK↑, TumCP↓, hepatoP↑, ATP↓, AMP↑, glucoNG↓, ROS↑, compI↓, DNAdam↑, CSCs↓, NP/CIPN↓, chemoP↑, toxicity↓, Trx↓, Synergy↑, cycD1/CCND1↓, CDK4↓, CDK6↓, cycE/CCNE↓, CDK2↓,
8687- MLT,    Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3
TumCP↓, TumCCA↑, Hif1a↓, NF-kB↓, Bcl-2↓, ROS↑, Akt↓, PCNA↓, cycD1/CCND1↓, BAX↓, Apoptosis?, ChemoSen↑, Wnt↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, PI3K↓, Akt↓, P53↑, P21↑, *cardioP?, *NRF2↑, *HO-1↑, *RenoP↑, chemoP↑,
1782- MLT,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, Synergy↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
8610- MO,    Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species
- in-vitro, CRC, HT-29 - in-vitro, Colon, T84
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, CDKN2C/p18↑, P21↑, cl‑Casp3↑, cl‑Casp7↑, Apoptosis↑, ROS↑, eff↓,
8899- MOR,    Morin Inhibits Proliferation, Migration, and Invasion of Bladder Cancer EJ Cells via Modulation of Signaling Pathways, Cell Cycle Regulators, and Transcription Factor-Mediated MMP-9 Expression
- in-vivo, Bladder, NA
TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p‑ERK↑, p‑JNK↓, p‑Akt↓, TumCMig↓, TumCI↓, MMP9↓, AP-1↓, Sp1/3/4↓, NF-kB↓,
8867- MOR,  doxoR,    Morin Sensitizes MDA-MB-231 Triple-Negative Breast Cancer Cells to Doxorubicin Cytotoxicity by Suppressing FOXM1 and Attenuating EGFR/STAT3 Signaling Pathways
- in-vitro, BC, MDA-MB-231
ChemoSen↑, EPR↑, DNAdam↑, γH2AX↑, p‑EGFR↓, p‑STAT3↓, TumCCA↑, P21↑, cycD1/CCND1↓, FOXM1↓, tumCV↓, *p38↑,
8886- MOR,  doxoR,    Morin overcomes doxorubicin resistance in human breast cancer by inducing DNA damage and modulating the LKB1/AMPK/mTORC1 signaling pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
DNAdam↑, DNArepair↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, CycB/CCNB1↓, PARP↓, Bcl-xL↓, p‑AMPK↑, p‑STK11/LKB1↑, p‑mTOR↓, p‑Akt↓, p‑GSK‐3β↓, tumCV↓,
8879- MOR,  doxoR,    Synergistic Effects of Morin and Doxorubicin Overcome Chemoresistance in Ovarian Cancer: Preclinical Insights From in vitro and in vivo Models
- vitro+vivo, Ovarian, OVCAR-3 - NA, Melanoma, A2780S
Dose↝, ChemoSen↑, cycA1/CCNA1↓, cycD1/CCND1↓, TumVol↓, Apoptosis↑, TumCCA↑, ROS↝, chemoP↑, TumAuto↑, ROS↓, SOD↑, Catalase↑, GSH↑, MDA↓, cardioP↑, mTOR↓, PI3K↓, Akt↓, Bcl-2↓, Casp3↑, Casp9↑, LC3A↑, ATG5↑, Beclin-1/ATG6↑,
8860- MOR,    Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis
- in-vitro, Cerv, HeLa - in-vitro, Nor, H4 - in-vitro, Lung, A549
NF-kB↓, IκB↓, survivin↓, Bcl-xL↓, cycD1/CCND1↓, COX2/PTGS2↓, MMP9↓, Akt↓, ChemoSen↑, Synergy↑,
8918- MP,  Cisplatin,    Mucuna pruriens (L.) DC chemo sensitize human breast cancer cells via downregulation of prolactin-mediated JAK2/STAT5A signaling
- in-vitro, BC, T47D - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-231
Dose?, TumCP↓, DNAdam↑, TumCCA↑, PRL↓, JAK2↓, STAT5↓, cycD1/CCND1↓, ChemoSen↑,
8777- MSM,  Tam,    The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts
- in-vitro, BC, MCF7 - in-vitro, BC, T47D
tumCV↓, TumCMig↓, JAK2↓, STAT5↓, ChemoSen↑, cycD1/CCND1↓, VEGF↓, IGF-1↓, IGF-1R↓, MMP2↓, MMP3↓, MMP9↓, TumVol↓, STAT3↓,
8774- MSM,    Methylsulfonylmethane Induces G1 Arrest and Mitochondrial Apoptosis in YD-38 Gingival Cancer Cells
- in-vitro, Oral, YD-38
P21↑, p27/CDKN1B↑, cycD1/CCND1↓, CDK4↓, Apoptosis↑, BAX↑, Bcl-2↓, Bcl-xL↓, Cyt‑c↑, TumCCA↑,
1182- MushCha,    Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29 - in-vitro, CRC, SW-620 - in-vitro, CRC, DLD1
Apoptosis↑, TumCG↓, FASN↓, β-catenin/ZEB1↓, cMyc↓, cycD1/CCND1↓, CDK8↓, Ki-67↓,
8935- MushCha,    Chaga Mushroom Triterpenoids Inhibit Dihydrofolate Reductase and Act Synergistically with Conventional Therapies in Breast Cancer
- in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-10AT
Ingr↝, tumCV↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, cycE/CCNE↓, ChemoSen↑, Imm↑, Dose↝, Ingr?,
8951- mushLions,    Apoptotic mechanisms of gastric cancer cells induced by isolated erinacine S through epigenetic histone H3 methylation of FasL and TRAIL
- vitro+vivo, GC, NA
Apoptosis↑, ROS↑, selectivity↑, TumCG↓, FasL↑, TRAIL↑, PCNA↓, cycD1/CCND1↓, Casp3↑, Casp9↑, Casp8↑, Bcl-2↓, Bcl-xL↓, TumCCA↑, tumCV↓, TumVol↓, TumW↓,
930- MushShi,    Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation
- in-vitro, Ovarian, NA
p‑STAT3↓, PTPN6↑, cycD1/CCND1↓, Bcl-2↓, Mcl-1↓, survivin↓, VEGF↓,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, Var, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2/PTGS2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
1805- NarG,    Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota
- in-vitro, Ovarian, A2780S - in-vivo, NA, NA
TumCP↓, TumCMig↓, PI3K↓, TumVol↓, TumW↓, BioAv↑, GutMicro↑, Dose∅, eff↑, EGFR↓, cycD1/CCND1↓, toxicity∅,
1269- NCL,    Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway
- in-vitro, Pca, DU145
STAT3↓, TumCG↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cMyc↓, Bcl-xL↓,
1267- NCL,    Niclosamide suppresses migration of hepatocellular carcinoma cells and downregulates matrix metalloproteinase-9 expression
- in-vitro, HCC, NA
TumCP↓, cycD1/CCND1↓, MMP9↓, TumCMig↓,
6493- Nimb,    Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment
- in-vivo, CRC, HCT116 - vitro+vivo, CRC, HT29
TumCP↓, Apoptosis↑, NF-kB↓, IKKα↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, cMyc↓, cycD1/CCND1↓, MMP9↓, CXCR4↓, ICAM-1↓, VEGF↓, angioG↓, TumCG↓,
1227- OLST,    Anti-Obesity Drug Orlistat Alleviates Western-Diet-Driven Colitis-Associated Colon Cancer via Inhibition of STAT3 and NF-κB-Mediated Signaling
- in-vivo, CRC, NA
OS↑, Inflam↓, TumCG↓, STAT3↓, NF-kB↓, β-catenin/ZEB1↓, Slug↓, XIAP↓, CDK4↓, cycD1/CCND1↓, Bcl-2↓,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, Synergy↑, Synergy↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1676- PBG,    Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
- Review, Var, NA
ROS↑, MMP↓, Bcl-2↓, Synergy↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,
1664- PBG,    Anticancer Activity of Propolis and Its Compounds
- Review, Var, NA
Apoptosis↑, TumCMig↓, TumCCA↑, TumCP↓, angioG↓, P21↑, p27/CDKN1B↑, CDK1↓, p‑CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, P70S6K↓, CLDN2↓, HK2↓, PFK↓, PKM2↓, LDHA↓, TLR4↓, H3↓, α-tubulin↓, ROS↑, Akt↓, GSK‐3β↓, FOXO3↓, NF-kB↓, cycD1/CCND1↓, MMP↓, ROS↑, i-Ca+2↑, lipid-P↑, ER Stress↑, UPR↑, PERK↑, eIF2α↑, GRP78/BiP↑, BAX↑, PUMA↑, ROS↑, MMP↓, Cyt‑c↑, cl‑Casp8↑, cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑,
4940- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G 0/G 1 Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, tumCV↓, ROS↑, Ca+2↑, CDC25↓, CDK6↓, cycD1/CCND1↓, CDK2↓, cycE/CCNE↓, P53↑, p27/CDKN1B↑, P21↑, Casp9↑, Casp3↑, GRP78/BiP↑,
5185- PEITC,  SFN,    Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
NF-kB↓, p65↓, VEGF↓, cycD1/CCND1↓, Bcl-xL↓, IKKα↓,
2940- PL,    Piperlongumine Induces Reactive Oxygen Species (ROS)-dependent Downregulation of Specificity Protein Transcription Factors
- in-vitro, PC, PANC1 - in-vitro, Lung, A549 - in-vitro, Kidney, 786-O - in-vitro, BC, SkBr3
ROS↑, TumCP↓, Apoptosis↑, eff↓, Sp1/3/4↓, cycD1/CCND1↓, survivin↓, cMyc↓, EGFR↓, cMET↓,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
1938- PL,    Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation
- Study, PSA, NA - in-vivo, NA, NA
ROS↑, Apoptosis↑, MMP↓, TumCCA↑, DNAdam↑, STAT3↓, Akt↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, Bcl-2↓, K17↓, HDAC↓, ROS↑, *IL1β↓, *IL6↓, *TNF-α↓, *IL17↓, *IL22↓,
5160- PLB,  VitK3,    Plumbagin, Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization
- in-vitro, Melanoma, U266
STAT3↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-xL↓, VEGF↓, Casp3↑, cl‑PARP↑, TumCCA↑, ChemoSen↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
4827- QC,  CUR,    Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin
- Review, Var, NA
*AntiCan↑, *Inflam↓, *Bacteria↓, *AntiDiabetic↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *NRF2↑, *Trx↑, *IronCh↑, *MDA↑, cycD1/CCND1↓, PI3K↓, Casp3↑, BAX↑, ChemoSen↑, ROS↑, Synergy↑, MMP↓, Cyt‑c↑, Akt↓, ERK↓,

Showing Research Papers: 251 to 300 of 381
Prev Page 6 of 8 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 381

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,   NA?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 6,   ARE↑, 1,   Catalase↑, 3,   ENOX2↓, 1,   Fenton↑, 1,   GPx↑, 2,   GPx1↓, 1,   GPx4↓, 3,   GSH↓, 14,   GSH↑, 6,   GSH/GSSG↓, 2,   GSR↓, 1,   GSR↑, 1,   GSSG↑, 1,   ox-GSSG↑, 1,   GSTs↓, 1,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 8,   HO-2↓, 1,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 4,   MDA↓, 1,   MDA↑, 2,   MPO↓, 1,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 12,   NRF2↝, 2,   Prx4↑, 1,   PYCR1↓, 1,   ROS↓, 20,   ROS↑, 148,   ROS⇅, 6,   ROS↝, 2,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 2,   mt-ROS↑, 2,   SOD↓, 3,   SOD↑, 5,   SOD1↓, 1,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 3,   TAC?, 1,   Thiols↓, 1,   Trx↓, 1,   TrxR↓, 2,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   BCR↓, 1,   Bfl-1↓, 1,   CDC16↓, 1,   CDC2↓, 6,   CDC25↓, 11,   compI↓, 2,   EGF↓, 2,   ETC↓, 1,   mitResp↓, 2,   MKK7↓, 1,   mtDam↑, 14,   OCR↓, 5,   OCR↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 1,   PDH↝, 1,   PINK1↑, 1,   SIRT3↓, 1,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 6,   ACC↑, 4,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 3,   ALAT↝, 1,   ALDOA↓, 1,   AMACR↓, 1,   AMP↑, 1,   AMPK↓, 3,   AMPK↑, 15,   AMPK↝, 1,   p‑AMPK↑, 1,   ATP↓, 12,   ATP↑, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   CholSyn↓, 1,   ECAR↓, 3,   ECAR↝, 1,   FAO↑, 1,   FASN↓, 4,   G6PD↓, 1,   GLS↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 6,   GlucoseCon∅, 1,   Glycolysis↓, 19,   GSK‐3β↓, 11,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 8,   H2S↑, 1,   Histones↑, 1,   HK1↓, 1,   HK2↓, 15,   IDO1↓, 1,   lactateProd↓, 8,   lactateProd∅, 1,   LDHA↓, 4,   LDL↓, 3,   NADPH↓, 3,   NADPH↑, 1,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   PFK↓, 3,   PKM2↓, 11,   PPP↓, 1,   SIRT1↓, 5,   SIRT1↑, 4,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 11,   APAF1↑, 6,   Apoptosis?, 3,   Apoptosis↓, 6,   Apoptosis↑, 173,   Apoptosis↝, 1,   Apoptosis∅, 1,   mt-Apoptosis↑, 3,   ASC↑, 1,   aSmase↝, 1,   BAD↓, 3,   BAD↑, 7,   Bak↑, 5,   BAX↓, 5,   BAX↑, 106,   BAX⇅, 1,   BAX↝, 3,   Bax:Bcl2↑, 30,   Bcl-2↓, 138,   Bcl-2↑, 3,   Bcl-2↝, 2,   Bcl-xL↓, 56,   Bcl-xL↑, 1,   Bcl-xL↝, 1,   BID↓, 1,   BID↑, 7,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 7,   BNIP3↑, 2,   BOK↑, 1,   Casp↓, 1,   Casp↑, 22,   Casp1↓, 1,   Casp1↑, 2,   Casp10↓, 1,   Casp10↑, 3,   Casp10∅, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3?, 1,   Casp3↓, 3,   Casp3↑, 133,   Casp3↝, 2,   cl‑Casp3↑, 18,   proCasp3↓, 1,   proCasp3↑, 1,   Casp7?, 1,   Casp7↑, 19,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 28,   Casp8∅, 1,   cl‑Casp8↑, 5,   proCasp8↑, 2,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 73,   cl‑Casp9↑, 9,   proCasp9↑, 1,   cFLIP↓, 6,   CSR1↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 66,   Cyt‑c↝, 2,   mt-Cyt‑c↓, 1,   Diablo↑, 15,   DR5↓, 1,   DR5↑, 18,   DR5∅, 1,   FADD↑, 2,   FADD∅, 1,   Fas↓, 1,   Fas↑, 11,   FasL↓, 1,   FasL↑, 3,   Ferroptosis↑, 4,   cl‑GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 13,   IAP2/BIRC3↓, 6,   IAP2/BIRC3↑, 1,   ICAD↓, 1,   ICD↑, 1,   iNOS↓, 17,   iNOS↑, 1,   Mcl-1↓, 28,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 10,   MDM2↑, 1,   NAIP↓, 1,   necrosis↑, 1,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 6,   p38↑, 14,   p‑p38↓, 2,   p‑p38↑, 1,   PUMA↓, 1,   PUMA↑, 6,   Pyro↑, 2,   RIP1↓, 1,   survivin↓, 81,   TNFR 1↑, 1,   TRAIL↑, 5,   TRAILR↑, 2,   TumCD?, 1,   TumCD↓, 1,   TumCD↑, 8,   XIAP↓, 29,   XIAP↝, 1,   YAP/TEAD↓, 4,   β-TRCP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 100,   Akt↑, 4,   Akt↝, 2,   p‑Akt↓, 32,   AKT1↓, 3,   Akt2↓, 2,   CaMKII ↓, 1,   CDC7↓, 1,   CIP2A↓, 1,   CK2↓, 2,   cMET↓, 4,   CREB↓, 1,   p‑CREB↓, 1,   cSrc↓, 3,   EF-1α↓, 1,   EGFR↓, 36,   EGFR↝, 1,   p‑EGFR↓, 3,   EphB4↓, 1,   ERK↓, 31,   ERK↑, 7,   p‑ERK↓, 15,   p‑ERK↑, 1,   FGFR1↓, 1,   FLT4↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 1,   IGF-1R↓, 8,   IGFR↓, 1,   IKKα↓, 10,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 2,   p‑IκB↓, 1,   JAK↓, 5,   JAK1?, 1,   JAK1↓, 7,   p‑JAK1↓, 1,   JAK2↓, 22,   p‑JAK2↓, 3,   JNK↓, 5,   JNK↑, 16,   JNK↝, 1,   p‑JNK↓, 2,   MAPK↓, 20,   MAPK↑, 6,   p‑MAPK↓, 2,   p‑MAPK↑, 1,   MARK4↓, 1,   MEK↓, 4,   MKK4↓, 2,   mTOR↓, 49,   mTOR↝, 2,   p‑mTOR↓, 8,   mTORC2↓, 3,   mTORC2↑, 1,   p70S6↓, 1,   P70S6K↓, 4,   p‑PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 75,   PI3K↝, 2,   p‑PI3K↓, 5,   PI3K/Akt↓, 2,   PKA↓, 1,   PKCδ↓, 7,   PTEN↓, 1,   PTEN↑, 18,   PTEN↝, 1,   PTPN6↑, 1,   Raf↓, 5,   c-Raf↓, 1,   RAS↓, 8,   RSK2/RPS6KA3/p90RSK2↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 3,   Sp1/3/4↓, 13,   Src↓, 2,   c-Src↓, 1,   STAT↓, 4,   STAT3↓, 70,   STAT3↑, 2,   p‑STAT3↓, 21,   p‑STAT3↑, 2,   STAT4↓, 1,   STAT5↓, 6,   STAT6↓, 3,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF1↓, 1,   ATF3↑, 1,   ATF4↓, 1,   ATF4↑, 7,   ATF4↝, 1,   ATFs↑, 1,   CBP↓, 1,   CBP↑, 1,   cJun↓, 6,   cJun↑, 2,   p‑cJun↑, 1,   cMyc↓, 63,   cMyc↑, 2,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 2,   DNMTs↓, 2,   EZH2↓, 5,   FOXM1↓, 7,   FOXO↑, 3,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 2,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 2,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↑, 3,   H4↑, 1,   ac‑H4↑, 2,   ac‑H4∅, 1,   HATs↓, 4,   HATs↑, 2,   HDAC↓, 17,   HDAC1↓, 6,   HDAC10↓, 1,   HDAC2↓, 5,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 2,   IRF1↑, 1,   miR-130a↓, 2,   miR-149↑, 1,   miR-155↓, 1,   miR-192-5p↑, 1,   miR-200b↑, 2,   miR-200c↑, 1,   miR-21↓, 4,   miR-27a-3p↓, 3,   miR-29b↑, 1,   miR-30a-5p↑, 1,   miR-34a↑, 9,   miR-590-3p↑, 1,   miR-99↑, 1,   MTA2↓, 1,   Myc↓, 4,   n-MYC↓, 2,   OCT4↓, 11,   other↓, 3,   other↑, 2,   other↝, 2,   PAX2↓, 1,   PCAF↓, 2,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 9,   SOX4↓, 2,   SOX4↑, 1,   SOX9?, 1,   SOX9↓, 1,   SPP1↓, 1,   SUV39H↓, 1,   TCF-4↓, 2,   TFE3↑, 1,   tumCV?, 1,   tumCV↓, 47,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

c-ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 16,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 4,   p‑eIF2α↑, 4,   ER Stress↓, 1,   ER Stress↑, 32,   GRP78/BiP↓, 1,   GRP78/BiP↑, 12,   GRP78/BiP↝, 1,   Hsc70↓, 1,   HSF1↓, 1,   HSP27↓, 4,   HSP27↝, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 3,   HSP70/HSPA5↝, 1,   HSP90↓, 8,   IRE1↑, 4,   PERK↑, 4,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 5,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   ATG5↑, 3,   ATG7↑, 3,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   LC3B-II↑, 2,   LC3II↓, 2,   LC3II↑, 8,   LC3s↑, 1,   MitoP↓, 1,   p62↓, 3,   p62↑, 2,   PARK2↑, 1,   TumAuto↓, 1,   TumAuto↑, 16,   TumAuto⇅, 1,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 6,   p‑ATM↑, 1,   ATR↑, 2,   p‑ATR↑, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↑, 1,   DNA-PK↓, 1,   DNAdam↓, 3,   DNAdam↑, 53,   DNArepair↓, 3,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC4/XPF↓, 1,   FEN1↓, 1,   HR↓, 1,   hTERT/TERT↓, 14,   Ku70/XRCC6↓, 1,   MSH2↑, 1,   NHEJ↓, 1,   p16↑, 6,   P53?, 1,   P53↓, 5,   P53↑, 83,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 4,   ac‑P53↑, 1,   PARP↓, 2,   PARP↑, 10,   PARP↝, 1,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 67,   proPARP↓, 1,   PARP1↓, 2,   PARP1↑, 4,   PCNA↓, 42,   PCNA↑, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 7,   TOP1↓, 3,   TOP2↓, 5,   TOP2↑, 2,   TP53↓, 1,   TP53↑, 3,   TRF2↓, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 7,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK1↑, 1,   p‑CDK1↓, 2,   CDK1/2/5/9↓, 1,   CDK1/2/5/9∅, 1,   CDK2↓, 75,   CDK2↑, 4,   p‑CDK2↓, 1,   CDK4↓, 106,   CDK4↑, 2,   CDK4∅, 1,   p‑CDK4↓, 1,   CDK4/6↓, 4,   CDK6↓, 39,   CDK6↑, 3,   CDK6∅, 1,   CDK8↓, 2,   CDKN1C/p57↓, 1,   CDKN1C/p57↑, 1,   CDKN2C/p18↑, 1,   CHK1↓, 2,   CHK1↑, 3,   p‑CHK1↑, 1,   Chk2↓, 1,   Chk2↑, 4,   p‑Chk2↑, 1,   Cyc↝, 1,   cycA1/CCNA1↓, 14,   cycA1/CCNA1↑, 3,   CycB/CCNB1↓, 26,   CycB/CCNB1↑, 5,   cycD1/CCND1↓, 366,   cycD1/CCND1↑, 8,   cycD1/CCND1↝, 2,   cycD1/CCND1∅, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 64,   cycE/CCNE↑, 5,   cycE1↓, 5,   cycF↓, 1,   E2F4↑, 1,   E2Fs↓, 10,   FBXO5/EMI1↓, 1,   Ki-67↓, 25,   MAD↓, 1,   mitA↓, 1,   mitA↑, 1,   P21?, 2,   P21↓, 8,   P21↑, 108,   P21↝, 2,   p27/CDKN1B↓, 6,   p27/CDKN1B↑, 56,   pRB↓, 2,   pRB↑, 2,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 4,   p‑RB1↓, 8,   Securin↓, 2,   TumCCA?, 1,   TumCCA↓, 8,   TumCCA↑, 220,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 5,   ALDH1A1↓, 4,   AXIN1↑, 2,   Axin2↓, 1,   BMP2↓, 1,   BMPs↑, 1,   CD133↓, 9,   CD24↓, 1,   cFos↓, 7,   CSCs↓, 33,   Diff↓, 2,   Diff↑, 2,   EIF4E↓, 1,   EP300↑, 1,   FBXW7↝, 1,   FGF↓, 1,   Gli↓, 2,   Gli1↓, 10,   HH↓, 9,   HMGCR↓, 1,   IGF-1↓, 6,   IGF-1↑, 1,   IGF-2↓, 1,   IGFBP3↑, 1,   Jun↓, 1,   p‑Jun↓, 1,   Ki-67↓, 25,   Let-7↑, 4,   LGR5↓, 1,   LRP6↓, 3,   p‑LRP6↓, 1,   mTORC1↓, 8,   p‑mTORC1↓, 1,   Nanog↓, 11,   Nestin↓, 2,   NF2↑, 1,   NICD↓, 1,   NOTCH↓, 12,   NOTCH⇅, 1,   NOTCH1↓, 11,   NOTCH1↑, 2,   NOTCH2↓, 1,   NOTCH3↓, 2,   p300↓, 3,   PTCH1↓, 4,   SCF↓, 1,   SFRP5↑, 1,   Shh↓, 9,   Smo↓, 3,   STAT1↓, 1,   TAZ↓, 1,   TOPflash↓, 1,   TumCG?, 1,   TumCG↓, 73,   TumCG↑, 1,   TumCP?, 1,   TumCP↓, 140,   TumCP↑, 2,   TumCP⇅, 1,   tyrosinase↓, 1,   URGCP/URG4↓, 1,   Wnt↓, 35,   Wnt↑, 1,   Wnt/(β-catenin)↓, 7,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↓, 1,   AP-1↓, 9,   AP-1↝, 1,   APC↑, 1,   ATPase↓, 1,   BACH1↓, 1,   Ca+2↓, 1,   Ca+2↑, 21,   Ca+2↝, 3,   i-Ca+2↑, 2,   cal2↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   Cdc42↑, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 36,   EMT↓, 49,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 6,   p‑FAK↓, 3,   Fibronectin↓, 5,   GIT1↓, 1,   GLI2↓, 4,   GLI3↑, 1,   GnT-V↝, 1,   heparanase↝, 1,   ITGA5↓, 2,   ITGB1↓, 1,   ITGB1↑, 1,   LAMs↓, 2,   LEF1↓, 2,   MALAT1↓, 1,   MET↓, 3,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 2,   MMP2↓, 70,   MMP2↝, 1,   MMP3↓, 5,   MMP7↓, 14,   MMP9↓, 88,   MMP9↑, 1,   MMPs↓, 18,   MUC4↓, 2,   N-cadherin↓, 21,   NCAM↑, 1,   NM23↑, 1,   p44↓, 1,   PAK1↓, 1,   PAK1↑, 1,   p‑pax↓, 1,   PDGF↓, 3,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Slug↓, 10,   Smad1↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 3,   SMAD3↑, 1,   p‑SMAD3↓, 2,   p‑SMAD4↓, 1,   Snail↓, 21,   TET1↑, 2,   TGF-β↓, 13,   TGF-β↑, 1,   TIMP1↓, 2,   TIMP1↑, 9,   TIMP2↑, 7,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 2,   TumCI↓, 54,   TumCI↑, 2,   TumCMig↓, 58,   TumCMig↑, 1,   TumMeta↓, 45,   TumMeta↑, 4,   Twist↓, 19,   uPA↓, 17,   uPAR↓, 1,   Vim↓, 28,   Zeb1↓, 13,   α-SMA↓, 3,   α-tubulin↓, 3,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 56,   β-catenin/ZEB1↑, 1,   β-catenin/ZEB1↝, 1,   p‑β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 55,   angioG↑, 1,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 7,   Endoglin↑, 1,   eNOS↓, 2,   eNOS↑, 1,   HIF-1↓, 2,   Hif1a↓, 42,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 5,   NO↑, 2,   VCAM-1↓, 1,   VEGF↓, 84,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 13,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 2,   CLDN2↓, 2,   EPR↑, 2,   GLUT1↓, 6,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 3,   MMP↓, 79,   MMP↑, 1,   MPT↑, 1,   NHE1↓, 2,   SLC12A5↝, 1,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD44↓, 9,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 72,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 2,   CXCL1↓, 1,   CXCL12↓, 2,   CXCR4↓, 17,   CXCR4↑, 1,   DR4↑, 6,   DR4∅, 1,   FOXP3↓, 3,   FOXP3↑, 1,   Gal-3↓, 1,   HCAR2↑, 1,   HLA↑, 1,   HMGB1↓, 2,   ICAM-1↓, 8,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 8,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 1,   IL4↑, 1,   IL6↓, 37,   IL6↑, 1,   IL6↝, 1,   IL7↓, 1,   IL8↓, 8,   Imm↑, 5,   Imm↝, 1,   Inflam↓, 26,   Inflam↝, 1,   IRAK1↓, 1,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   MIP2↓, 2,   NF-kB↓, 125,   NF-kB↑, 3,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 2,   p65↓, 9,   p‑p65↓, 4,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 2,   PD-L1↓, 5,   PD-L1↑, 1,   PGE2↓, 15,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 1,   RANTES↓, 1,   SOCS1↑, 1,   T-Cell↑, 2,   TCF↓, 4,   TCF↑, 1,   TCF↝, 1,   Th1 response↑, 1,   TLR4↓, 5,   TLR4↝, 1,   TNF-α↓, 26,   TNF-α↑, 6,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   TRADD↑, 1,   TRAF1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   PLC↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   4-OHE1↓, 1,   AhR↓, 2,   AhR↑, 1,   AR↓, 14,   AR↝, 1,   ER-α36↓, 2,   ER(estro)↓, 2,   ERα/ESR1↓, 1,   PPARα↓, 2,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 6,   PRL↓, 1,   RANKL↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 20,   BioAv↑, 24,   BioAv↝, 5,   BioEnh↑, 4,   ChemoSen↓, 3,   ChemoSen↑, 104,   CompStab↑, 2,   CompStab↝, 2,   CYP1A1↓, 3,   CYP1B1↓, 1,   CYP1B1↑, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 26,   Dose∅, 10,   DrugR↓, 1,   eff↓, 26,   eff↑, 38,   eff↝, 7,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↝, 7,   MDR1↓, 5,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 12,   P450↓, 3,   RadioS↑, 27,   selectivity?, 1,   selectivity↑, 52,   Synergy↑, 68,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 3,   ALAT↝, 1,   ALP↓, 3,   ALP↝, 1,   AR↓, 14,   AR↝, 1,   ascitic↓, 2,   AST↓, 1,   AST↝, 1,   BRCA1↑, 3,   p‑BRCA1↑, 1,   CRP↓, 2,   EGFR↓, 36,   EGFR↝, 1,   p‑EGFR↓, 3,   ERα/ESR1↓, 1,   EZH2↓, 5,   Ferritin↓, 1,   FOXM1↓, 7,   HEC1↓, 1,   HER2/EBBR2↓, 8,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 14,   IL6↓, 37,   IL6↑, 1,   IL6↝, 1,   LDH↓, 10,   Myc↓, 4,   NOS2↓, 1,   PD-L1↓, 5,   PD-L1↑, 1,   PSA↓, 9,   PSA↝, 1,   RAGE↓, 1,   TP53↓, 1,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 26,   AntiCan∅, 1,   antiNeop↑, 2,   AntiTum↑, 11,   cachexia↓, 1,   cardioP↑, 7,   CardioT↓, 1,   chemoP↑, 15,   chemoPv↑, 15,   ChemoSideEff↓, 4,   FTO↑, 1,   hepatoP↑, 10,   IMPDH1↓, 1,   IMPDH2↓, 1,   K17↓, 1,   neuroP↑, 7,   NKG2D↑, 1,   NP/CIPN↓, 2,   OS↑, 9,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 5,   TGFβR1↑, 1,   toxicity↓, 9,   toxicity↑, 2,   toxicity↝, 1,   toxicity∅, 2,   TumVol↓, 24,   TumVol↑, 1,   TumW↓, 9,   Weight↓, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 1007

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 46,   ARE↑, 1,   Catalase↑, 20,   GPx↑, 16,   GSH↑, 20,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 8,   H2O2↓, 2,   HDL↑, 2,   HO-1↓, 1,   HO-1↑, 11,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 13,   MDA↓, 14,   MDA↑, 1,   NQO1↑, 4,   Nrf1↑, 1,   NRF2↑, 23,   RNS↓, 1,   ROS↓, 45,   mt-ROS?, 1,   SOD↓, 1,   SOD↑, 23,   Trx↑, 1,   Trx1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   Insulin↑, 1,   PGC-1α↑, 1,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 4,   adiP↑, 1,   ALAT↓, 5,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP↑, 1,   CRM↑, 1,   ECAR∅, 1,   FASN↓, 1,   glucose↓, 5,   glucose↝, 1,   glyC↓, 1,   LDL↓, 1,   lipidLev↓, 2,   NAD↑, 1,   NADPH↑, 2,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 2,   BAX↓, 2,   Bcl-2↑, 1,   Casp↓, 1,   Casp3↓, 4,   Fas↓, 1,   Ferroptosis↓, 1,   iNOS↓, 9,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 1,   CREB↑, 1,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 3,   IκB?, 1,   JNK↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 4,   MAPK↑, 2,   PI3K↓, 3,   PI3K↑, 1,   PTEN↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   other?, 1,   other↝, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   p16↓, 1,   P53↓, 1,   P53↑, 1,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   Ki-67↓, 1,   P21↓, 1,   P21↑, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

ACTA2↓, 1,   AntiAg↑, 6,   Ca+2↓, 1,   Ca+2↝, 2,   COL1A1↓, 1,   LRP1↑, 1,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MUC1↑, 1,   Rho↓, 1,   TGF-β↓, 2,   TumCI↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   E-sel↓, 1,   Hif1a↓, 2,   NO↓, 3,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   GastroP↑, 1,   IBI↑, 2,   MMP↑, 3,   MUC5AC↓, 1,   TRPC1↓, 1,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 15,   COX2/PTGS2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 2,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL22↓, 1,   IL6↓, 16,   IL8↓, 3,   Imm↑, 2,   Inflam↓, 50,   Inflam↑, 1,   IRF3↓, 1,   pol-M2 MC↑, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 23,   NLRP3↓, 1,   PGE2↓, 6,   PGE2↑, 1,   RAGE↓, 2,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 3,   TNF-α↓, 14,   TRIF↓, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 5,   AChE↑, 1,   BDNF↑, 5,   GABA↑, 2,   MAOA↓, 1,   NGF↑, 1,   TPH1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 8,   BACE/β-secretase↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   FGF21↑, 1,   GPER↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 15,   BioAv↑, 16,   BioAv↝, 6,   ChemoSen↑, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↝, 1,   eff↑, 3,   GSTA1↑, 1,   Half-Life↝, 4,   Half-Life∅, 1,   P450↓, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   AST↓, 7,   BMD↑, 2,   BP↓, 4,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 1,   IL6↓, 16,   LDH↓, 4,   LDH↑, 1,   RAGE↓, 2,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 10,   AntiArt↑, 6,   AntiCan↑, 8,   AntiDiabetic↑, 10,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 2,   cardioP?, 1,   cardioP↑, 21,   chemoP↑, 2,   chemoPv↑, 4,   cognitive↑, 9,   hepatoP↑, 15,   Learn↑, 1,   memory↑, 12,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 37,   Obesity↓, 5,   OS↑, 1,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 5,   Risk↓, 1,   Stroke↓, 4,   toxicity↓, 13,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 4,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiP↑, 4,   AntiViral↑, 3,   Bacteria↓, 9,   GutMicro↑, 5,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 263

Scientific Paper Hit Count for: cycD1/CCND1, cyclin D1 pathway
20 Quercetin
19 Thymoquinone
16 Curcumin
14 Fisetin
13 Lycopene
10 Resveratrol
9 Boswellia (frankincense)
8 Garcinol
7 Berberine
7 Chrysin
7 Sulforaphane (mainly Broccoli)
7 Ferulic acid
7 Honokiol
7 Magnolol
6 Silver-NanoParticles
6 Licochalcone A
5 Apigenin (mainly Parsley)
5 Artemisinin
5 Baicalein
5 D-limonene
5 Ellagic acid
5 Eugenol
5 Gallic acid
5 Licorice
5 Morin
5 salinomycin
5 Silymarin (Milk Thistle) silibinin
5 Shikonin
4 Cisplatin
4 Caffeic acid
4 Metformin
4 Indole-3-carbinol
4 Formononetin
4 HydroxyTyrosol
4 Isoliquiritigenin
4 Luteolin
4 doxorubicin
4 Piperlongumine
3 Beta-Caryophyllene
3 Betulinic acid
3 Capsaicin
3 Carvacrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Ursolic acid
3 Diindolylmethane
3 EGCG (Epigallocatechin Gallate)
3 Gambogic Acid
3 Ginkgetin
3 phytic acid, Inositol hexakisphosphate
3 Ivermectin
3 lambertianic acid
3 Propolis -bee glue
3 Vitamin K2
2 Sorafenib (brand name Nexavar)
2 Astragalus
2 Allicin (mainly Garlic)
2 Anethole/trans-Anethole
2 Astaxanthin
2 Berbamine
2 Bufalin/Huachansu
2 Chemotherapy
2 Carnosic acid
2 Celastrol
2 Cucurbitacin
2 Cyclopamine
2 tamoxifen
2 Flaxseed/Linseed
2 Ginger/6-Shogaol/Gingerol
2 Graviola
2 Hibiscus sabdariffa
2 Melatonin
2 Methylsulfonylmethane
2 Mushroom Chaga, Inonotus obliquus
2 Niclosamide (Niclocide)
2 Phenethyl isothiocyanate
2 VitK3,menadione
2 Rosmarinic acid
1 2-DeoxyGlucose
1 Alpha-Lipoic-Acid
1 Andrographis
1 Gemcitabine (Gemzar)
1 Fennel Oil/Foeniculum vulgare
1 Isovitexin
1 Ashwagandha(Withaferin A)
1 Radiotherapy/Radiation
1 borneol
1 Boron
1 Butyrate
1 Caffeine
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chlorogenic acid
1 Chlorophyllin
1 Crocetin
1 Dihydrocaffeic Acid
1 Docosahexaenoic Acid
1 diet Methionine-Restricted Diet
1 Dandelion Root
1 Disulfiram
1 Copper and Cu NanoParticles
1 Emodin
1 Evodiamine
1 Fenbendazole
1 SDG/lignans
1 Fucoidan
1 chitosan
1 Geraniol
1 Ginseng
1 5-fluorouracil
1 Grapeseed extract
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 chaetocin
1 Baicalin
1 isoorientin
1 itraconazole
1 Juglone
1 Kaempferol
1 Lapachol
1 Lemongrass Extract/Citral
1 Lutein
1 Matrine
1 Modified Citrus Pectin
1 Lemon Balm/Melissa officinalis
1 Mucuna pruriens/Velvet Bean
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Mushroom Shiitake, AHCC
1 Myricetin
1 Naringin
1 Nimbolide
1 Orlistat
1 Plumbagin
1 Pterostilbene
1 Paclitaxel/Taxol
1 Rauwolfia serpentina/Indian Snakeroot
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Urolithin
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:73  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page