Cyt‑c Cancer Research Results

Cyt‑c, cyt-c Release into Cytosol: Click to Expand ⟱

Source:

Type:

Cytochrome c
** The term "release of cytochrome c" ** an increase in level for the cytosol.
Small hemeprotein found loosely associated with the inner membrane of the mitochondrion where it plays a critical role in cellular respiration. Cytochrome c is highly water-soluble, unlike other cytochromes. It is capable of undergoing oxidation and reduction as its iron atom converts between the ferrous and ferric forms, but does not bind oxygen. It also plays a major role in cell apoptosis.

The term "release of cytochrome c" refers to a critical step in the process of programmed cell death, also known as apoptosis.
In its new location—the cytosol—cytochrome c participates in the apoptotic signaling pathway by helping to form the apoptosome, which activates caspases that execute cell death.
Cytochrome c is a small protein normally located in the mitochondrial intermembrane space. Its primary role in healthy cells is to participate in the electron transport chain, a process that helps produce energy (ATP) through oxidative phosphorylation.
Mitochondrial outer membrane permeability leads to the release of cytochrome c from the mitochondria into the cytosol.
The release of cytochrome c is a pivotal event in apoptosis where cytochrome c moves from the mitochondria to the cytosol, initiating a chain reaction that leads to programmed cell death.

On the one hand, cytochrome c can promote cancer cell survival and proliferation by regulating the activity of various signaling pathways, such as the PI3K/AKT pathway. This can lead to increased cell growth and resistance to apoptosis, which are hallmarks of cancer.
On the other hand, cytochrome c can also induce apoptosis in cancer cells by interacting with other proteins, such as Apaf-1 and caspase-9. This can lead to the activation of the intrinsic apoptotic pathway, which can result in the death of cancer cells.
Overexpressed in Breast, Lung, Colon, and Prostrate.
Underexpressed in Ovarian, and Pancreatic.

Scientific Papers found: Click to Expand⟱

7370-

HibSad,

Hibiscus sabdariffa leaf induces apoptosis of human prostate cancer cells in vitro and in vivo

-

vitro+vivo,

Pca,

LNCaP

n xenograft tumour studies.

-

in-vitro,

Pca,

PC3

-

in-vitro,

Pca,

DU145

eff↑, Dose↝, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, FasL↑, eff↑, TumW↓, TumVol↓, other↝,

7365-

HibSad,

Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L

-

Review,

Var,

NA

chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,

7363-

HibSad,

Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation

-

in-vitro,

GC,

NA

Apoptosis↑, selectivity↑, p‑p38↑, JNK↑, cJun↑, Cyt‑c↑, Fas↑, FasL↑,

7357-

HibSad,

Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells

-

in-vitro,

CRC,

LoVo

0, 1, 2, and 3 mg/mL) were administered over 0, 12, 24, and 48 h

Apoptosis↑, AMPK↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑Casp3↑, Dose↝, mtDam↑, MMP↓, Akt↓,

7350-

HibSad,

Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway

-

in-vitro,

GC,

AGS

TumCD↑, DNAdam↑, P53↑, Bcl-2↓, Mcl-1↓, Cyt‑c↑, FasL↑, Fas↑, p38↑, BAX↑, Dose↝, TumCCA↑,

7463-

HNK,

Honokiol Inhibits Colorectal Cancer Cell Growth: Involvement of Hsp27 as a Molecular Target

-

in-vitro,

CRC,

NA

TumCG↓, TumCCA↑, Cyt‑c↑, Apoptosis↑, cl‑PARP↑, Bcl-2↓, HSP27↓,

2879-

HNK,

Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function

-

in-vitro,

Lung,

H226

-

in-vivo,

NA,

NA

mouse

tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,

2883-

HNK,

Honokiol targets mitochondria to halt cancer progression and metastasis

-

Review,

Var,

NA

ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,

2885-

HNK,

Honokiol: a novel natural agent for cancer prevention and therapy

-

Review,

Var,

NA

NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,

2872-

HNK,

Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis

-

in-vivo,

ALS,

NA

mice

-

NA,

Stroke,

NA

-

NA,

AD,

NA

-

NA,

Park,

NA

*eff↑, *ROS↓, *GSH↑, *NRF2↑, *motorD↑, *OS↑, *neuroP↑, *BBB↑, *cognitive↑, *Stroke↓, *antiOx↑, *Cyt‑c↑, *PGC-1α↑,

2867-

HNK,

Honokiol ameliorates oxidative stress-induced DNA damage and apoptosis of c2c12 myoblasts by ROS generation and mitochondrial pathway

-

in-vitro,

Nor,

C2C12

*antiOx↑, *ROS↓, *Bcl-2↑, *BAX↓, Casp9∅, Casp3∅, cl‑PARP∅, Cyt‑c?,

4523-

HNK,

MAG,

BA,

Honokiol-Magnolol-Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti-PD-1 Immunotherapy in Colorectal Cancer by Triggering GSDME-Dependent Pyroptosis

-

in-vitro,

CRC,

HCT116

-

in-vitro,

CRC,

LoVo

-

in-vivo,

CRC,

HCT116

mice

AntiCan↑, eff↑, TumCP↓, TumCCA↓, cycD1/CCND1↓, Pyro↑, Apoptosis↑, cl‑GSDME↑, Bcl-2↓, Cyt‑c↑, Casp9↑, TumCG↓,

5052-

HPT,

Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells

-

in-vitro,

OS,

U2OS

Apoptosis↑, ROS↑, Casp3↑, mtDam↑, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Bak↑, BAX↓, ER Stress↑, Ca+2↝, cal2↑,

886-

HPT,

Impact of hyper- and hypothermia on cellular and whole-body physiology

-

Analysis,

Var,

NA

MMP↓, OXPHOS↓, ATP↓, ROS↑, Apoptosis↑, Cyt‑c↑,

7535-

HT,

Hydroxytyrosol acetate from olive leaves (Olea Europaea L.) induces apoptosis via mitochondrial pathway in BEL7402 cell line

-

in-vitro,

Liver,

Bel-7402

TumCP↓, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, Apoptosis↑,

4640-

HT,

The anti-cancer potential of hydroxytyrosol

-

Review,

Var,

NA

selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,

7567-

HYP,

Hyperoside: A review on its sources, biological activities, and molecular mechanisms

-

Review,

Var,

NA

*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,

7554-

HYP,

Effect of hyperoside on the apoptosis of A549 human non‑small cell lung cancer cells and the underlying mechanism

-

in-vitro,

NSCLC,

A549

10, 50 and 100 µM

tumCV↓, Apoptosis↑, p‑MAPK↑, JNK↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, AIF↑,

7612-

I3C,

Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells

-

in-vitro,

Nor,

MCF10

selectivity↑, Bax:Bcl2↓, Bcl-xL↓, BAX↑, MMP↓, Cyt‑c↑, TumCD↑,

7586-

I3C,

Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cells

-

in-vitro,

BC,

NA

TumCG↓, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, TumCCA↑,

7591-

I3C,

Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway

-

in-vitro,

NPC,

CNE2

Apoptosis↑, MMP↓, XIAP↓, IAP1↓, survivin↓, Diablo↑, Cyt‑c↑, HTRA2/Omi/PARK13↑, mtDam↑, Fas↑, FasL↑,

7772-

IBC,

Isobavachalcone inhibits acute myeloid leukemia: Potential role for ROS-dependent mitochondrial apoptosis and differentiation

-

vitro+vivo,

AML,

NA

NOD/SCID mice

Apoptosis↑, Diff↑, tumCV↓, TumCP↓, MMP↓, BAX↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, p‑MEK↑, p‑ERK↑, ROS↑, eff↓,

7674-

iod,

Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway

-

in-vitro,

BC,

NA

AntiTum↑, selectivity↑, MMP↓, antiOx↑, Thiols↓, Bcl-2↓, BAX↑, eff↓, Casp↑, ROS↓, ROS↑, Cyt‑c↑, AIF↑,

7724-

IP6,

Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkappaB-mediated cell survival pathway

-

in-vitro,

Cerv,

HeLa

NF-kB↓, Akt↓, MMP↓, Cyt‑c↑, Apoptosis↑, Casp3↑, Casp9↑, PARP↑, eff↑,

7747-

ISL,

Isoliquiritigenin Induces Apoptosis via ROS-Mediated Inhibition of p38/mTOR/STAT3 Pathway in Human Melanoma Cells

-

in-vitro,

Melanoma,

SK-MEL-28

*Inflam↓, *AntiViral↑, *AntiTum↑, *antiOx↑, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Cyt‑c↑, cycD1/CCND1↓, cycD1/CCND1↓, survivin↓, ROS↓, eff↓, p‑mTOR↓, p‑STAT3↓, p‑MAPK↓,

7763-

ISL,

Harnessing Liquiritigenin: A Flavonoid-Based Approach for the Prevention and Treatment of Cancer

-

Review,

Var,

NA

AntiCan↑, *antiOx↓, *Inflam↓, TumCP↓, Apoptosis↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, *AntiArt↑, Casp8↑, Cyt‑c↑, Casp↑, cl‑PARP↑, GutMicro↑, BioAv↑, BioAv↓, Half-Life↓,

7855-

isoO,

Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells

-

in-vitro,

Liver,

HepG2

-

in-vitro,

Nor,

HL7702

TumAuto↑, Beclin-1/ATG6↑, LC3II↑, eff↓, ROS↑, Fas↑, P53↓, PI3K↓, Akt↓, NF-kB↓, Cyt‑c↑, Casp3↑, cl‑PARP↑,

7854-

isoO,

Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells

-

in-vitro,

Liver,

HepG2

TumCD↑, selectivity↑, *toxicity↓, cl‑PARP↑, DNAdam↑, Bax:Bcl2↑, MMP↓, Cyt‑c↑, Casp3↑, ROS↑, NO↑, p‑Akt↓, FOXO4↑, eff↓,

7853-

isoO,

Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review

-

Review,

Var,

NA

Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,

7885-

isoO,

Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway

-

in-vitro,

Liver,

HepG2

Dose↝, tumCV↓, TumCP↓, LDH↑, TumCCA↑, ROS↑, MMP↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp3↑, Casp9↑,

7866-

isoO,

Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects

-

Review,

Var,

NA

TumCP↓, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, *toxicity↓, Bax:Bcl2↑, Cyt‑c↑, Diablo↑, Casp9↑, Casp3↑, cl‑PARP↑, DNAdam↑, γH2AX↑, ROS↑, PCNA↓, MMP2↓, MMP9↓, TumCCA↑, cycD1/CCND1↓, CDK4↓, P21↑, NF-kB↓, HH↓, Ki-67↓, COX2/PTGS2↓, TNF-α↓, ChemoSen↑, chemoP↑, eff↑, angioG↓,

8027-

IVM,

Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin

-

Review,

Var,

NA

*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,

8039-

IVM,

Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy

-

in-vitro,

neuroblastoma,

SH-SY5Y

*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,

8045-

IVM,

Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway

-

in-vitro,

Cerv,

HeLa

tumCV↓, TumCCA↑, DNA-PK↑, ChrMod↝, MMP↓, Bax:Bcl2↑, Cyt‑c↓, Casp9↑, Casp3↑, ROS↑, TumCMig↓,

7893-

IVT,

Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress

-

vitro+vivo,

Liver,

NA

TumCG↓, Apoptosis↑, BAX↑, cl‑Casp3↑, cl‑PARP↑, Cyt‑c↑, TumAuto↑, LC3II↑, ATG3↑, ATG5↑, Beclin-1/ATG6↑, ER Stress↑, IRE1↑, XBP-1↑, CHOP/DDIT3↑, GRP78/BiP↑, *chemoPv↑,

5113-

JG,

Juglone in Oxidative Stress and Cell Signaling

-

Review,

Var,

NA

-

Review,

AD,

NA

ROS↑, Pin1↓, antiOx⇅, *ROS↓, SMAD2↓, GSH↓, lipid-P↑, TumCCA↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Ca+2↑, Cyt‑c↑, AntiFungal↑, Bacteria↓, Akt↓,

5114-

JG,

Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism

-

in-vitro,

AML,

HL-60

IC50 value ∼8 μM

ROS↑, GSH↓, eff↓, cl‑PARP↑, proCasp3↑, proCasp9↑, MMP↓, Cyt‑c↑, Diablo↑,

1927-

JG,

Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway

-

in-vitro,

GC,

SGC-7901

5, 10, 15 and 20 μmol/L 24h

36.51 μmol/L (24h) and 25.37 μmol/L (48 h)

Apoptosis↑, ROS↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, Casp3?, Bax:Bcl2↑,

1926-

JG,

Mechanism of juglone-induced apoptosis of MCF-7 cells by the mitochondrial pathway

-

in-vitro,

BC,

MCF7

11.99 μM

TumCG↓, ROS↑, MMP↓, i-Ca+2↑, BAX↑, Bcl-2↓, Cyt‑c↑, Casp3?,

1924-

JG,

Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway

-

in-vitro,

Lung,

A549

2-8uM

9.47 μM@24h

TumCMig↓, TumCI↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Cyt‑c↑, ROS↑, MDA↑, GPx4↓, SOD↓, PI3K↓, Akt↓, eff↓,

1923-

JG,

Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells

-

in-vitro,

Endo,

NA

20.81 μM

TumCP↓, TumCCA↑, cycA1/CCNA1↓, ROS↑, P21↑, CDK2↓, CDK1↓, CDC25↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Cyt‑c↑,

8095-

KAE,

Kaempferol: A Key Emphasis to Its Anticancer Potential

-

Review,

Var,

NA

*AntiBio↑, *Inflam↓, *AntiTum↓, *antiOx↑, *cardioP↑, *neuroP↑, *AntiDiabetic↑, Risk↓, TumCCA↑, EMT↓, PI3K↓, Akt↓, MMP2↓, Casp3↑, Casp7↑, Casp9↑, PARP↑, *ROS↓, angioG↓, *BioAv↑, BioAv↑, selectivity↑, GLUT1↓, MCT1↓, ROS↓, ROS↑, Trx↓, Cyt‑c↑, MMP↓, miR-21↓, SOCS-3↓, STAT3↓, CDK1↓, CycB/CCNB1↑, HIF-1↓, JAK1↑, PTEN↑,

8105-

KAE,

Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

-

Review,

Var,

NA

Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,

8060-

KAE,

Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells

-

in-vitro,

CRC,

HT-29

TumCCA↑, DNAdam↑, ChrCon↑, cl‑Casp9↑, cl‑Casp3↑, cl‑Casp7↑, cl‑PARP↑, MPT↑, Cyt‑c↑, Bcl-xL↓, Bak↑, Akt↓, BAD↑, Casp↑, MMP↓,

8072-

KAE,

Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation

-

Review,

CRC,

NA

AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, Synergy↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,

8080-

KAE,

Hepatoprotective Effect of Kaempferol—A Review

-

Review,

Nor,

NA

*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,

8055-

KAE,

Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review

-

Review,

Var,

NA

antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,

8161-

LapC,

Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells

-

in-vitro,

ESCC,

KYSE-30

-

in-vitro,

ESCC,

KYSE450

-

in-vitro,

ESCC,

KYSE-510

RSK2/RPS6KA3/p90RSK2↓, TumCG↓, Apoptosis↑, Casp3↑, Casp7↑, PARP↑, Cyt‑c↑, BAX↑, p‑CREB↓, ATF1↓, H3↓, CycB/CCNB1↓, cycD1/CCND1↓, p‑CDK2↓,

8175-

Las,

Lasiodin Inhibits Proliferation of Human Nasopharyngeal Carcinoma Cells by Simultaneous Modulation of the Apaf-1/Caspase, AKT/MAPK and COX-2/NF-κB Signaling Pathways

-

in-vitro,

NPC,

NA

tumCV↓, TumCMig↓, APAF1↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, p‑Akt↓, p‑ERK↓, p‑p38↓, p‑JNK↓, COX2/PTGS2↓, NF-kB↓, chemoPv↑,

8237-

LCA,

Role of Licochalcone A in Potential Pharmacological Therapy: A Review

-

Review,

Var,

NA

*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑, *antiAll↑, *MUC5AC↓, *E-sel↓, *CCL11↓,

Showing Research Papers: 251 to 300 of 464
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 464

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

NA⇅, 1, NA?, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3, antiOx↑, 5, antiOx⇅, 1, Catalase↓, 10, Catalase↑, 3, Ceru↓, 1, Copper↑, 1, Fenton↑, 5, GCLM↓, 1, GPx↓, 5, GPx4↓, 6, GSH↓, 41, GSH↑, 6, mt-GSH↓, 1, GSH/GSSG↓, 6, GSR↓, 1, GSR↑, 1, GSTs↓, 3, GSTs↑, 2, GSTs↝, 1, H2O2↑, 8, i-H2O2↑, 1, mt-H2O2↑, 1, HO-1↓, 8, HO-1↑, 12, HO-1⇅, 1, HO-2↓, 1, Iron↑, 2, c-Iron↑, 1, Keap1↓, 1, lipid-P↓, 4, lipid-P↑, 18, MDA↓, 3, MDA↑, 8, MPO↓, 1, NADH↓, 2, NADPH/NADP+↓, 1, NQO1↓, 2, NQO1↑, 2, NRF2↓, 16, NRF2↑, 15, NRF2⇅, 1, NRF2↝, 1, p‑NRF2↓, 1, p‑NRF2↑, 1, Prx↓, 1, Prx4↑, 1, PrxII↓, 1, ROS?, 1, ROS↓, 19, ROS↑, 274, ROS⇅, 5, ROS↝, 1, i-ROS↑, 4, mt-ROS↑, 8, SOD↓, 15, SOD↑, 5, SOD2↓, 5, SOD2↑, 4, TAC↓, 1, TBARS↓, 1, Thiols↓, 3, Trx↓, 2, Trx1↓, 1, Trx1↑, 1, Trx2↓, 1, TrxR↓, 5, TrxR1↓, 2, VitC↓, 1, VitE↓, 1, xCT/SLC7A11↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2, FTH1↓, 2, IronCh↑, 2, NCOA4↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 7, CDC25↓, 14, compI↓, 2, compIII↓, 1, compV↓, 1, EGF↓, 4, ETC↓, 5, ETC↝, 1, HTRA2/Omi/PARK13↑, 1, MFN2↓, 1, MFN2↑, 1, mitResp↓, 6, mitResp↑, 1, MKK7↓, 1, mtDam↑, 33, OCR↓, 7, OCR↑, 1, OXPHOS↓, 2, OXPHOS↑, 5, mt-OXPHOS↓, 3, PDH↓, 1, PDH↑, 2, PDH↝, 1, PINK1↑, 2, SDH↓, 1, SIRT3↓, 1, SIRT3↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 4, 5LO↓, 1, ACC↓, 1, ACC↑, 2, ACSL4↑, 2, ALAT↓, 1, ALAT∅, 1, AMP↑, 1, AMPK?, 1, AMPK↓, 2, AMPK↑, 20, AMPK↝, 1, p‑AMPK↑, 2, ATP↓, 24, CAIX/CA9↓, 1, ECAR↓, 1, ECAR↝, 1, FABP4↑, 1, FASN↓, 4, GALNT10↓, 1, GAPDH↓, 2, glucoNG↓, 1, GlucoseCon↓, 9, GlutaM↓, 1, GlutMet↓, 1, Glycolysis↓, 29, GSK‐3β↓, 7, GSK‐3β↑, 6, p‑GSK‐3β↓, 6, H2S↑, 1, HK2?, 1, HK2↓, 18, lactateProd↓, 13, lactateProd↑, 2, LDHA↓, 7, LDL↓, 2, NADPH↓, 1, NADPH↑, 2, PCK1↓, 1, PDK1 / PDPK1?, 2, PDK1 / PDPK1↓, 8, PDKs↓, 1, PFK↓, 2, PFKP↓, 1, PKM2↓, 7, PKM2↑, 1, PKM2∅, 1, Pyruv↓, 1, p‑S6↓, 1, SIRT1↓, 9, SIRT1↑, 1, SREBP1/SREBF1↓, 1, TCA?, 1, TCA↓, 2, TS↓, 1, Warburg↓, 3,

Cell Death(tgid=5) ⓘ

AIF↑, 35, AIF↝, 1, APAF1↑, 14, Apoptosis?, 1, Apoptosis↓, 8, Apoptosis↑, 260, Apoptosis↝, 1, mt-Apoptosis↑, 3, ASC↓, 1, ASK1↑, 2, BAD↓, 2, BAD↑, 24, Bak↓, 1, Bak↑, 16, BAX↓, 4, BAX↑, 192, BAX⇅, 1, BAX↝, 2, Bax:Bcl2↓, 1, Bax:Bcl2↑, 44, Bcl-2↓, 173, Bcl-2↑, 1, Bcl-2↝, 2, cl‑Bcl-2↑, 1, Bcl-xL↓, 36, Bcl-xL↑, 2, Bcl-xL↝, 1, BID↑, 14, cl‑BID↑, 4, BIM↓, 1, BIM↑, 7, BNIP3?, 1, BNIP3↓, 1, BNIP3↑, 2, BNIP3↝, 1, BOK↑, 1, Casp↑, 58, cl‑Casp↑, 3, Casp1↓, 1, Casp1↑, 1, cl‑Casp1↑, 1, Casp10↑, 2, Casp12↑, 12, cl‑Casp12↑, 1, Casp2↑, 1, Casp3?, 2, Casp3↓, 6, Casp3↑, 210, Casp3↝, 2, Casp3∅, 2, cl‑Casp3↑, 54, cl‑Casp3⇅, 1, proCasp3↓, 2, proCasp3↑, 3, pro‑Casp3↑, 1, Casp6↑, 4, Casp7↑, 15, cl‑Casp7↑, 6, Casp8↓, 2, Casp8↑, 55, Casp8∅, 3, cl‑Casp8↑, 9, proCasp8↓, 1, proCasp8↑, 1, Casp9?, 1, Casp9↓, 1, Casp9↑, 153, Casp9∅, 1, cl‑Casp9↓, 1, cl‑Casp9↑, 29, proCasp9↓, 3, proCasp9↑, 2, cFLIP↓, 6, Cupro↑, 2, Cyt‑c↓, 5, Cyt‑c↑, 421, Cyt‑c↝, 8, Cyt‑c?, 1, mt-Cyt‑c↓, 1, Diablo↑, 22, DR5↑, 32, Endon↑, 4, FADD↑, 12, Fap1↓, 1, Fas↓, 1, Fas↑, 39, FasL↑, 21, FasL⇅, 1, Ferroptosis↑, 7, cl‑GSDMD↑, 1, cl‑GSDME↑, 1, GSDME-N↑, 1, HEY1↓, 1, IAP1↓, 11, IAP1↑, 1, IAP2/BIRC3↓, 4, cl‑IAP2/BIRC3↑, 1, ICAD↓, 2, ICAD↑, 1, ICD↑, 1, iNOS↓, 14, Mcl-1?, 1, Mcl-1↓, 26, cl‑Mcl-1↑, 1, MDM2↓, 11, MDM2↑, 2, p‑MDM2↓, 2, MLKL↑, 1, p‑MLKL↓, 1, MOMP↓, 2, MOMP↑, 8, NAIP↓, 1, Necroptosis↑, 2, necrosis↑, 2, NOXA↑, 3, p38↓, 5, p38↑, 27, p‑p38↓, 2, p‑p38↑, 7, Paraptosis↑, 1, PUMA↑, 6, Pyro↑, 5, RIP1↓, 1, RIP3↑, 1, p‑RIP3↑, 1, survivin↓, 49, TNFR 1↑, 1, TRAIL↑, 5, TRAILR↑, 1, TumCD?, 1, TumCD↑, 27, XIAP↓, 31, YAP/TEAD↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1, Akt↓, 104, Akt↑, 5, Akt↝, 1, p‑Akt↓, 34, p‑Akt↑, 1, AKT1↓, 3, Akt2↓, 1, AMPKα↑, 1, BRAF↓, 1, CaMKII ↓, 1, CIP2A↓, 1, CK2↓, 4, cMET↓, 1, p‑cMET↑, 1, p‑CREB↓, 1, CREB2↓, 1, cSrc↓, 1, DYRK1B↓, 1, EGFR↓, 33, EGFR↑, 2, EGFR↝, 1, p‑EGFR↓, 3, ERK↓, 41, ERK↑, 10, p‑ERK↓, 14, p‑ERK↑, 3, p‑ERK↝, 1, FGFR1↓, 1, HCAR2↑, 1, HER2/EBBR2↓, 13, HGF/c-Met↓, 3, Hippo↓, 1, IGF-1R↓, 2, IGF-1R↑, 1, IGFR↓, 2, IKKα↓, 3, IKKα↑, 2, IκB↓, 1, IκB↑, 1, p‑IκB↓, 1, p‑IκB↑, 1, JAK↓, 2, JAK1↓, 3, JAK1↑, 1, JAK2↓, 4, p‑JAK2↓, 2, JNK↓, 7, JNK↑, 29, JNK↝, 1, p‑JNK↓, 2, p‑JNK↑, 7, MAP2K1/MEK1↓, 1, MAPK?, 1, MAPK↓, 30, MAPK↑, 14, MAPK↝, 1, p‑MAPK↓, 1, p‑MAPK↑, 2, MEK↓, 8, p‑MEK↑, 1, MKK4↓, 1, MKP1↓, 1, MKP2↓, 1, mTOR↓, 48, mTOR↑, 1, mTOR↝, 3, p‑mTOR↓, 11, mTORC2↓, 4, p70S6↓, 2, p70S6↑, 1, P70S6K↓, 4, p‑P70S6K↓, 1, P90RSK↓, 1, PDGFR-BB↓, 1, PI3K↓, 71, PI3K↑, 2, PI3K↝, 1, p‑PI3K↓, 8, PI3K/Akt↓, 3, PI3k/Akt/mTOR↝, 1, PIK3CA↓, 1, PKA↓, 2, PKCδ↓, 10, PP2A↑, 1, PRAS40↑, 1, PTEN↓, 1, PTEN↑, 15, PTEN↝, 1, Raf↓, 5, RAS↓, 9, RSK2/RPS6KA3/p90RSK2↓, 1, SHP1↑, 1, Sp1/3/4↓, 11, Src↓, 2, p‑Src↓, 1, STAT3↓, 34, STAT3↑, 1, p‑STAT3↓, 13, STAT5↓, 1, STAT6↓, 1, p‑STAT6↓, 1, THEM4/CTMP↑, 1, TSC2↑, 2,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1, ATF1↓, 1, ATF3↓, 1, ATF3↑, 3, ATF4↓, 1, ATF4↑, 13, ATF4↝, 1, ChrMod↑, 1, ChrMod↝, 1, cJun↓, 7, cJun↑, 3, p‑cJun↑, 1, cMyc↓, 21, DNMT1↓, 4, DNMT3A↓, 2, DNMTs↓, 6, FOXM1↓, 2, FOXO↑, 2, FOXO1↓, 2, FOXO3↓, 4, FOXO3↑, 6, p‑FOXO3↓, 1, FOXO4↓, 1, FOXO4↑, 1, H3↓, 4, H3↑, 1, p‑H3↓, 1, p‑H3↑, 1, ac‑H3↑, 1, H4↓, 1, H4↑, 1, ac‑H4↑, 1, HATs↓, 5, HATs↑, 2, HDAC↓, 22, HDAC1↓, 2, HDAC10↑, 1, HDAC3↓, 1, HDAC8↓, 1, HES1↓, 1, KCNQ1OT1↓, 1, miR-122-5p↑, 1, miR-203↑, 1, miR-21↓, 3, miR-21↑, 1, miR-22↑, 2, miR-34a↓, 1, miR-34b-5p↑, 1, miR-384↑, 1, miR-497↑, 1, miR-548ah-5p↑, 1, Myc↓, 3, OCT4↓, 6, other?, 1, other↓, 3, other↑, 3, other↝, 8, PAX2↓, 1, sonoS↑, 1, SOX2↓, 3, SOX4↓, 1, SOX4↑, 1, SOX9↓, 1, TCF-4↓, 2, TFAP2A↓, 1, TFE3↑, 1, tumCV?, 1, tumCV↓, 66, tumCV↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2, cl‑ATF6↑, 2, CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 36, eIF2α↓, 1, eIF2α↑, 7, p‑eIF2α↓, 1, p‑eIF2α↑, 4, ER Stress↓, 1, ER Stress↑, 62, GRP78/BiP?, 1, GRP78/BiP↓, 3, GRP78/BiP↑, 20, GRP94↑, 2, HSF1↓, 1, HSP27↓, 6, HSP27↑, 2, HSP27↝, 1, HSP70/HSPA5↓, 9, HSP70/HSPA5↑, 1, HSP70/HSPA5↝, 1, HSP72↓, 1, HSP90↓, 11, HSPs↓, 2, IRE1↑, 8, PERK↑, 13, UPR↑, 12, XBP-1↓, 1, XBP-1↑, 4,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1, ATG16L1↑, 1, ATG3↑, 2, ATG5↑, 9, ATG7↑, 1, Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 15, CTSB↓, 1, CTSD↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 4, LC3A↑, 2, LC3B↑, 3, LC3B-II↑, 2, LC3I↑, 1, LC3II↑, 13, LC3s↓, 1, LC3s↑, 3, MitoP↑, 2, p62↓, 5, p62↑, 5, PARK2↑, 2, RUBCN↓, 1, SESN2↑, 2, TumAuto↓, 1, TumAuto↑, 37, ULK1/ATG1↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↑, 1, ATM↑, 2, BRCA1↓, 1, BRCA2↓, 1, DFF45↓, 1, DFF45↑, 1, DNA-PK↑, 1, DNAdam↓, 1, DNAdam↑, 65, mt-DNAdam↑, 1, DNArepair↓, 2, ERCC1↓, 1, ERCC4/XPF↓, 1, hTERT/TERT↓, 12, Ku70/XRCC6↓, 1, p16↑, 4, P53?, 1, P53↓, 3, P53↑, 89, P53↝, 4, p‑P53↑, 5, PARP↓, 7, PARP↑, 21, PARP↝, 1, p‑PARP↑, 1, cl‑PARP↓, 2, cl‑PARP↑, 99, cl‑PARP∅, 1, PARP1↑, 1, cl‑PARP1↑, 4, PCNA↓, 24, RAD51↓, 1, SIRT6↓, 1, SIRT6↑, 1, Telomerase↓, 17, TOP1↓, 9, TOP1∅, 1, TOP2↓, 6, TP53↓, 1, TRF2↓, 1, γH2AX↑, 7, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1, CDK1↓, 15, CDK1↑, 1, p‑CDK1↓, 2, CDK2↓, 33, CDK2↑, 3, p‑CDK2↓, 1, CDK4↓, 43, CDK4↑, 2, CDK6↓, 18, CDK6↑, 2, CDK8↓, 1, CHK1↓, 2, CHK1↑, 2, Chk2↓, 2, Chk2↑, 2, ChrCon↑, 1, Cyc↓, 3, Cyc↝, 1, cycA1/CCNA1↓, 9, cycA1/CCNA1↑, 2, CycB/CCNB1↓, 19, CycB/CCNB1↑, 4, cycD1/CCND1↓, 67, cycD1/CCND1↑, 2, cycD1/CCND1↝, 2, CycD3↓, 3, cycE/CCNE↓, 23, cycE/CCNE↑, 1, cycF↓, 1, E2Fs↓, 1, GADD45A↓, 1, Ki-67↓, 16, MAD↓, 1, mitA↓, 1, mitA↑, 3, p19↑, 1, P21↓, 3, P21↑, 67, P21↝, 2, p27/CDKN1B↑, 26, pRB↑, 1, p‑pRB↓, 3, RB1↑, 2, p‑RB1↓, 5, Securin↓, 1, TubPol↓, 1, TumCCA?, 2, TumCCA↓, 9, TumCCA↑, 165, WEE1↑, 2,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 2, p‑4E-BP1↓, 1, ALDH↓, 3, ALDH1A1↓, 1, CD133↓, 3, CD24↓, 1, CD34↓, 2, CEBPA↑, 1, cFos↓, 7, cFos↑, 1, CSCs↓, 22, Diff↑, 2, EIF4E↓, 1, FGF↓, 2, Gli↓, 1, Gli1↓, 6, HH↓, 3, IGF-1↓, 7, IGF-2↓, 1, IGFBP3↓, 1, IGFBP3↑, 5, Jun↓, 1, Ki-67↓, 16, Let-7↑, 1, mTORC1↓, 7, Nanog↓, 4, NOTCH↓, 12, NOTCH1↓, 5, NOTCH1↑, 2, NOTCH3↓, 1, PTCH1↓, 1, PTCH2↓, 1, SCF↓, 1, Shh↓, 4, Smo↓, 3, STAT1↓, 1, TumCG↓, 73, TumCG↑, 2, TumCP?, 1, TumCP↓, 102, TumCP↑, 3, Wnt?, 1, Wnt↓, 27, Wnt↑, 1, Wnt/(β-catenin)↓, 2,

Migration(tgid=13) ⓘ

AntiAg↓, 1, AntiAg↑, 1, AP-1↓, 5, AP-1↝, 1, ATPase↓, 1, AXL↓, 3, BACH1↓, 1, CA↓, 1, Ca+2↓, 3, Ca+2↑, 59, Ca+2↝, 2, i-Ca+2?, 1, i-Ca+2↑, 3, CAFs/TAFs↓, 2, cal2↓, 1, cal2↑, 5, CCN2/CTGF↓, 1, Cdc42↓, 2, E-cadherin↓, 6, E-cadherin↑, 34, EMT↓, 47, EMT↑, 1, EpCAM↓, 1, F-actin↓, 1, FAK↓, 16, p‑FAK↓, 3, Fibronectin↓, 3, GLI2↓, 2, ITGB1↓, 2, ITGB3↓, 1, ITGB4↓, 1, ITGB6↓, 1, KRAS↓, 1, LAMs↓, 2, LRP1↓, 1, MALAT1↓, 1, MET↓, 4, p‑MET↓, 1, MMP-10↓, 3, MMP1↓, 5, MMP13↓, 2, MMP16↓, 1, MMP2↓, 62, MMP2↝, 1, proMMP2↓, 1, MMP3↓, 6, MMP7↓, 10, MMP9↓, 66, MMP9↑, 1, MMPs↓, 24, MRGPRF↓, 1, MTA1↓, 1, MUC4↓, 1, N-cadherin↓, 25, p44↓, 1, PAK1↑, 1, pax↓, 1, PDGF↓, 5, Rac1↓, 2, RECK↑, 1, Rho↓, 5, ROCK1↓, 2, ROCK1↑, 1, Slug?, 1, Slug↓, 8, Smad1↑, 3, SMAD2↓, 1, p‑SMAD2↓, 1, SMAD3↓, 2, p‑SMAD3↓, 1, SMAD4↓, 1, p‑SMAD4↓, 1, Snail?, 2, Snail↓, 23, TET1↓, 1, TET1↑, 3, TGF-β↓, 12, TGF-β↑, 3, TIMP1↓, 1, TIMP1↑, 5, TIMP2↓, 4, TIMP2↑, 9, TIMP3↑, 1, TRIB3↑, 2, TSC1↑, 1, TSP-1↑, 2, TumCA↓, 1, TumCA↑, 1, TumCI↓, 50, TumCI↑, 1, TumCMig↓, 37, TumCMig↑, 1, TumMeta?, 1, TumMeta↓, 47, TumMeta↑, 3, Twist↓, 16, Tyro3↓, 1, uPA↓, 25, uPA↝, 1, uPAR↓, 2, Vim↓, 24, Vim↑, 1, Zeb1↓, 9, Zeb1↑, 1, ZEB2↓, 2, α-SMA↓, 1, α-SMA↑, 1, α-tubulin↓, 1, α-tubulin↑, 1, β-catenin/ZEB1↓, 33, β-catenin/ZEB1↝, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 68, angioG↑, 1, CD31/PECAM-1↓, 3, Endoglin↑, 1, eNOS↓, 1, HIF-1↓, 4, Hif1a↓, 43, Hif1a↑, 2, LOX1↓, 2, NO↓, 3, NO↑, 4, NO↝, 1, VCAM-1↓, 2, VEGF↓, 74, VEGF↝, 1, VEGFR1↓, 3, VEGFR2/KDR/Flk1↓, 14, p‑VEGFR2/KDR/Flk1↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1, BBB↑, 6, BBB∅, 1, CellMemb↓, 1, CLDN1↓, 2, CLDN2↓, 2, CLDN2↑, 1, EPR↑, 4, EPR↝, 1, GLUT1↓, 8, GLUT2↓, 1, GLUT3↓, 1, GLUT4↓, 1, MMP?, 1, MMP↓, 235, MMP↑, 2, MPT↑, 16, NHE1↓, 3, TRPM7↓, 2, TRPV1↑, 5, ZO-1↑, 3,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1, CD4+↓, 1, CD4+↑, 3, CD44↓, 12, CD8+↑, 2, cDC2↓, 1, COX1↓, 2, COX2/PTGS2↓, 59, COX2/PTGS2↑, 2, COX2/PTGS2↝, 2, CXCL12↓, 1, CXCR2↓, 1, CXCR4↓, 9, CXCR4↑, 1, DR4↑, 10, DR4∅, 1, FOXP3↑, 2, HCAR2↑, 1, HMGB1↓, 2, ICAM-1↓, 5, IFN-γ↓, 3, IFN-γ↑, 1, IL1↓, 4, IL1↑, 1, IL10↓, 4, IL12↓, 1, IL12↑, 1, IL1β↓, 13, IL1β↑, 2, IL2↓, 1, IL2↑, 3, IL4↓, 2, IL6↓, 22, IL6↝, 1, IL8↓, 6, IL8↑, 1, Imm↑, 7, Imm↝, 4, Inflam↓, 22, M2 MC↓, 2, MCP1/CCL2↓, 5, MCT1↓, 2, MDSCs↓, 1, NF-kB?, 1, NF-kB↓, 106, NF-kB↑, 10, NF-kB↝, 1, NK cell↑, 1, NLRP3↓, 2, p50↓, 2, p65↓, 3, p‑p65↓, 1, p‑p65↑, 1, PD-1↓, 3, PD-L1↓, 7, PGE2↓, 14, PSA↓, 4, PSA↝, 1, RAGE↓, 1, RANTES?, 1, SOCS-3↓, 1, T-Cell↑, 1, TCF↑, 1, TCF↝, 1, TLR4↓, 6, TNF-α↓, 23, TNF-α↑, 4, TNF-α↝, 1, TNF-α∅, 1, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,

Synaptic & Neurotransmission(tgid=18) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1, AR↓, 12, AR↝, 1, AR-V7?, 1, CYP19?, 1, ER-α36↓, 2, ER(estro)↓, 1, Estro↝, 1, PPARα↓, 1, PPARα↑, 1, cl‑PPARα↓, 1, PPARγ↓, 1, PPARγ↑, 4, SXR↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2, BioAv↓, 23, BioAv↑, 22, BioAv↝, 7, BioEnh↑, 5, ChemoSen?, 1, ChemoSen↑, 100, CompStab↑, 3, CompStab↝, 1, CYP1A1↓, 3, CYP1A1↑, 2, CYP1A2↑, 1, CYP2A3/CYP2A6↓, 1, CYP2E1↑, 1, CYP3A4↓, 4, DDS↑, 1, Dose↓, 2, Dose↑, 4, Dose↝, 42, Dose∅, 6, eff↓, 58, eff↑, 91, eff↝, 13, GSTA1↓, 1, GSTA1↑, 1, GSTZ1↝, 1, Half-Life↓, 6, Half-Life↝, 6, MDR1↓, 4, MRP1/ABCC1↓, 2, P-gp/ABCB1↓, 11, P450↓, 3, P450↝, 1, RadioS?, 1, RadioS↑, 37, RadioS↝, 1, selectivity↓, 1, selectivity↑, 95, selectivity∅, 1, Synergy↑, 67, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2, ALAT↓, 1, ALAT∅, 1, ALP↓, 2, AR↓, 12, AR↝, 1, AST↓, 1, AST∅, 1, BMD↑, 1, BRAF↓, 1, BRCA1↓, 1, CEA↓, 2, creat↓, 1, CRP↓, 2, E6↓, 2, E7↓, 2, EGFR↓, 33, EGFR↑, 2, EGFR↝, 1, p‑EGFR↓, 3, Ferritin↓, 2, FOXM1↓, 2, HER2/EBBR2↓, 13, hTERT/TERT↓, 12, IL6↓, 22, IL6↝, 1, KRAS↓, 1, LDH?, 1, LDH↓, 7, LDH↑, 6, LDH↝, 2, i-LDH↓, 1, Myc↓, 3, NSE↓, 1, PD-L1↓, 7, PSA↓, 4, PSA↝, 1, RAGE↓, 1, TG/TAG↓, 1, TP53↓, 1, TRIB3↑, 2,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 40, antiNeop↑, 1, AntiTum↓, 1, AntiTum↑, 18, cachexia↓, 2, cardioP↑, 9, CardioT↑, 1, chemoP↑, 18, chemoPv↑, 18, ChemoSideEff↓, 2, fatigue↓, 1, hepatoP↓, 1, hepatoP↑, 7, hepatoP∅, 1, Mucositis↓, 1, neuroP↑, 5, NP/CIPN↓, 1, NP/CIPN↑, 1, Obesity↓, 1, OS↑, 9, Pain↓, 1, Pin1↓, 1, QoL↑, 3, radioP↑, 4, Remission↑, 1, RenoP↑, 8, Risk↓, 16, Sleep↑, 1, toxicity↓, 10, toxicity↑, 4, toxicity↝, 6, toxicity∅, 3, TumVol↓, 13, TumW↓, 8, Weight↑, 3, Weight∅, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1, Bacteria↓, 2, GutMicro↑, 5, GutMicro↝, 2, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1, Ingr↝, 1,
Total Targets: 1019

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1, antiOx↓, 2, antiOx↑, 68, ARE↑, 1, Catalase↑, 24, GPx↑, 18, GPx1↑, 1, GPx4↑, 2, GSH↑, 28, GSH/GSSG↑, 1, GSR↓, 1, GSR↑, 4, GSTs↓, 1, GSTs↑, 8, H2O2↓, 3, HDL↑, 1, HO-1↓, 1, HO-1↑, 15, i-Iron↓, 1, Keap1↓, 2, Keap1↑, 1, Keap1↝, 1, lipid-P↓, 20, mt-lipid-P↓, 1, MDA↓, 17, MDA↑, 1, MPO↓, 5, NADH↓, 1, NOX4↓, 1, NQO1↑, 3, Nrf1↑, 1, NRF2↓, 1, NRF2↑, 33, Prx↑, 1, RNS↓, 3, ROS↓, 64, ROS↑, 6, ROS↝, 1, ROS∅, 2, mt-ROS?, 1, SOD↓, 1, SOD↑, 34, SOD1↑, 2, SOD2↓, 1, SOD2↑, 3, TAC↑, 3, TBARS↓, 2, Trx↓, 1, Trx↑, 2, uricA↓, 1, xCT/SLC7A11↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1, Mets↝, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1, FIS1↓, 1, Insulin↑, 1, MFN2↑, 1, mitResp↑, 1, mtDam↓, 3, PGC-1α↑, 4, PGC-1α↝, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2, ALAT↓, 15, AMPK↓, 1, AMPK↑, 4, ATP↓, 1, ATP↑, 4, ATP∅, 1, cytoP450↓, 1, DGAT1↓, 1, FASN↓, 1, GAPDH↑, 1, glucose↓, 3, glucose↝, 1, GSK‐3β↓, 4, p‑GSK‐3β↑, 1, H2S↑, 1, LDHA↑, 1, LDL↓, 3, lipidLev↓, 3, NAD↓, 1, NADH:NAD↑, 1, NADPH↑, 1, PONs↓, 1, SIRT1↑, 7,

Cell Death(tgid=5) ⓘ

AIF↓, 2, AIF↑, 1, APAF1↓, 1, Apoptosis↓, 12, Apoptosis∅, 1, ASK1↓, 1, BAX↓, 14, BAX↑, 2, Bax:Bcl2↝, 1, Bcl-2↓, 2, Bcl-2↑, 9, Bcl-2∅, 1, Bcl-xL↓, 1, Casp12↓, 1, Casp3?, 1, Casp3↓, 16, Casp3∅, 2, cl‑Casp3↓, 3, Casp8↓, 1, Casp9↓, 7, Casp9∅, 1, cl‑Casp9↓, 2, Cyt‑c↓, 24, Cyt‑c↑, 5, Cyt‑c∅, 4, Ferroptosis↓, 2, IAP1↓, 1, iNOS↓, 11, iNOS↑, 1, MLKL↓, 1, necrosis↓, 1, p38↓, 1, RIP1↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5, Akt↑, 1, Akt2↓, 1, CaMKII ↓, 1, CREB↑, 1, ERK↓, 1, ERK↑, 3, IGF-1R↓, 1, IKKα↓, 1, IκB?, 1, JAK↓, 2, JNK↓, 1, p‑JNK↓, 2, MAPK↓, 4, mTOR↑, 1, PDGFR-BB↓, 1, PI3K↓, 5, PI3K↑, 1, PKCδ↓, 1, STAT3↓, 1, STAT3↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1, ATF4↓, 1, p‑cJun↓, 1, p‑cMyc↑, 1, FOXO↑, 1, HDAC↓, 1, HDAC3↓, 1, other↓, 2, other↑, 5, other↝, 7, RUNX2↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1, CHOP/DDIT3↓, 2, ER Stress↓, 2, GRP78/BiP↓, 1, HSP27↓, 1, HSP27↑, 1, HSP70/HSPA5↑, 3, HSP70/HSPA5↝, 1, HSPs↓, 1, HSPs↑, 1, IRE1↓, 1, PERK↓, 1, UPR↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 3, Beclin-1/ATG6↑, 2, LC3II↓, 1, LC3II↑, 1, p62↑, 2,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3, p16↓, 1, P53↓, 4, P53↑, 1, PARP↓, 2, PARP∅, 1, PARP1↓, 1, PCNA↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1, CDK2↓, 1, CDK4↓, 1, CycB/CCNB1↓, 1, cycD1/CCND1↓, 1, cycE/CCNE↓, 1, E2Fs↑, 1, GADD34↓, 1, Ki-67↓, 1, P21↓, 2, P21↑, 1, RB1↓, 1, TumCCA↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, Diff↑, 1, IGF-1↑, 1, Ki-67↓, 1, TumCG↑, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 6, AP-1↓, 1, Ca+2?, 1, Ca+2↓, 1, Ca+2↑, 1, Ca+2↝, 2, cal2↓, 1, COL1↓, 1, COL1↑, 1, E-cadherin↓, 1, MLC2/MYL9↝, 1, MMP13↓, 1, MMP2↓, 1, MMP3↓, 1, MMP9↓, 2, PAI-1/SERPINE1↓, 1, Rho↓, 1, ROCK1↓, 1, p‑SMAD2↓, 1, p‑SMAD3↑, 1, TGF-β↓, 1, TIMP1↓, 1, TregCell↑, 1, Zeb1↓, 1, α-SMA↓, 2,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2, angioG↑, 1, E-sel↓, 1, Hif1a↓, 1, Hif1a↑, 1, HIF2a↑, 1, NO↓, 8, NO↑, 1, VCAM-1↓, 2, VEGF↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2, BBB↑, 10, GastroP↑, 2, GLUT1↑, 1, GLUT3↑, 1, GLUT4↑, 1, MMP↓, 2, MMP↑, 13, MMP∅, 2, MPT↑, 1, MUC5AC↓, 1, OCLN↝, 1, TJ↑, 1, TRPA1↑, 1, TRPV1↑, 1, ZO-1↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCL11↓, 1, CD4+↑, 1, CD8+↑, 1, COX1↓, 3, COX2/PTGS2↓, 16, COX2/PTGS2↑, 1, CXCR4↓, 1, HMGB1↓, 1, ICAM-1↓, 1, IFN-γ↓, 3, IL1↓, 2, IL10↓, 4, IL10↑, 3, IL17↓, 5, IL18↓, 2, IL1β↓, 12, IL2↓, 1, IL23↓, 1, IL4↓, 1, IL6↓, 16, IL6↑, 1, IL8↓, 2, Imm↓, 1, Imm↑, 3, Inflam↓, 66, Inflam↑, 2, pol-M2 MC↑, 1, MCP1/CCL2↓, 1, MyD88↓, 2, NF-kB↓, 21, NF-kB↑, 1, p65↓, 1, PAF↓, 1, PGE2↓, 8, PGE2↑, 1, RAGE↓, 1, SOCS-3↓, 1, Th1 response↓, 1, Th2↑, 2, TLR1↓, 1, TLR4↓, 3, TNF-α↓, 28, TRAF6↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2, AChE↓, 7, BChE↓, 3, BDNF↓, 1, BDNF↑, 4, GABA↑, 1, MAOA↓, 1, NGF↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 11, Aβ42↓, 1, BACE/β-secretase↓, 5, IDE↑, 1, tau↓, 2, p‑tau↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1, Estro↓, 1, PPARα↑, 1, PPARγ↓, 1, PPARγ↑, 5,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 21, BioAv↑, 23, BioAv↝, 4, BioAv∅, 1, BioEnh↑, 2, CompStab↑, 1, CYP2E1↓, 2, Dose⇅, 1, Dose↝, 7, Dose∅, 1, eff↓, 2, eff↑, 16, eff↝, 1, Half-Life↓, 5, Half-Life↑, 1, Half-Life↝, 8, Half-Life∅, 1, P-gp/ABCB1↓, 2, P450↓, 1, P450↝, 1, selectivity↑, 1, Synergy↑, 4,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15, ALB↝, 1, ALP↓, 3, AST↓, 14, BP↓, 4, BUN↓, 3, creat↓, 4, CRP↓, 3, hs-CRP↓, 1, IL6↓, 16, IL6↑, 1, LDH↓, 7, LDH↑, 1, NOS2↓, 1, RAGE↓, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, AntiAge↑, 2, antiAll↑, 12, AntiArt↑, 7, AntiCan↑, 8, antiD↓, 1, AntiDiabetic↑, 12, antiPs↑, 2, AntiTum↓, 1, AntiTum↑, 1, Bone Healing↑, 1, cardioP↑, 24, chemoP↑, 5, chemoPv↑, 4, cognitive↑, 11, diuretic↑, 1, hepatoP↓, 1, hepatoP↑, 20, Learn↑, 1, memory↑, 9, motorD↑, 4, Mucositis↓, 1, neuroP?, 1, neuroP↑, 44, NP/CIPN↓, 1, Obesity↓, 5, OS↑, 1, Pain↓, 3, radioP↑, 2, RenoP↑, 7, Risk↓, 1, Stroke↓, 5, toxicity↓, 21, toxicity↑, 3, toxicity↝, 4, toxicity∅, 4, Wound Healing↑, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 7, AntiFungal↑, 3, AntiP↑, 3, AntiViral↑, 7, Bacteria↓, 12, Diar↓, 1, GutMicro↑, 10, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1, Ingr↝, 4,
Total Targets: 393

Scientific Paper Hit Count for: Cyt‑c, cyt-c Release into Cytosol

16 Silver-NanoParticles
16 Betulinic acid
15 Curcumin
15 Fisetin
14 Baicalein
14 Sulforaphane (mainly Broccoli)
12 Apigenin (mainly Parsley)
12 Quercetin
11 Thymoquinone
10 Berberine
10 Emodin
9 Allicin (mainly Garlic)
9 Capsaicin
9 Luteolin
9 Phenethyl isothiocyanate
8 Carvacrol
8 Chrysin
7 Honokiol
7 Magnolol
7 Kaempferol
7 Licochalcone A
6 EGCG (Epigallocatechin Gallate)
6 Eugenol
6 Gambogic Acid
6 Juglone
6 Magnetic Fields
6 Silymarin (Milk Thistle) silibinin
5 Artemisinin
5 Graviola
5 Hibiscus sabdariffa
5 isoorientin
5 Resveratrol
5 Vitamin K2
4 3-bromopyruvate
4 Propolis -bee glue
4 Cisplatin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Thymol-Thymus vulgaris
4 Lycopene
4 Morin
4 Nimbolide
4 Shikonin
4 Selenite (Sodium)
3 Ashwagandha(Withaferin A)
3 Photodynamic Therapy
3 Crocetin
3 Dichloroacetate
3 D-limonene
3 Dandelion Root
3 Ellagic acid
3 Formononetin
3 Garcinol
3 Ginkgetin
3 Indole-3-carbinol
3 Ivermectin
3 Matrine
3 mebendazole
3 Magnetic Field Rotating
3 Rosmarinic acid
3 Spermidine
2 Chemotherapy
2 Celastrol
2 Citric Acid
2 Copper and Cu NanoParticles
2 Ursolic acid
2 Cynaropicrin
2 salinomycin
2 Diclofenac
2 Electrical Pulses
2 Eurycomanone
2 Radiotherapy/Radiation
2 Evodiamine
2 Flaxseed/Linseed
2 Gossypol/AT-101
2 Hyperthermia
2 HydroxyTyrosol
2 Hyperoside
2 Isoliquiritigenin
2 Licorice
2 methylseleninic acid
2 Methylglyoxal
2 Melatonin
2 Moringa oleifera
2 Methylsulfonylmethane
2 Phenylbutyrate
2 Piperine
2 Piperlongumine
2 Plumbagin
2 Aflavin-3,3′-digallate
1 1,8-Cineole
1 5-fluorouracil
1 Coenzyme Q10
1 Astragalus
1 chemodynamic therapy
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 Gemcitabine (Gemzar)
1 Ajoene (compound of Garlic)
1 Alpha-Lipoic-Acid
1 alpha Linolenic acid
1 Andrographis
1 Metformin
1 2-DeoxyGlucose
1 Biochanin A
1 Bufalin/Huachansu
1 Bromelain
1 Boron
1 Bullatacin
1 Butyrate
1 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
1 Cat’s Claw
1 chaetocin
1 Chlorophyllin
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Cinnamon
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Diindolylmethane
1 Fenbendazole
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Gallic acid
1 Ginkgo biloba
1 Ginkgolide B
1 Hydroxycinnamic-acid
1 Baicalin
1 Isobavachalcone
1 iodine
1 phytic acid, Inositol hexakisphosphate
1 Isovitexin
1 Lapachol
1 Lasiodin
1 Geldanamycin
1 SDG/lignans
1 Methylene blue
1 Methyl Jasmonate
1 magnetic nanoparticles
1 Iron
1 Mangiferin
1 Mistletoe/Viscum album Extracts
1 Pterostilbene
1 Paclitaxel/Taxol
1 Rauwolfia serpentina/Indian Snakeroot
1 α-Santalol/Sandalwood oil
1 Selenium
1 chitosan
1 Selenium NanoParticles
1 Docetaxel
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 VitK3,menadione
1 Vitexin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:77  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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