AntiCan Cancer Research Results

AntiCan, Anticancer Effect: Click to Expand ⟱
Source:
Type: general indicator
Anticancer Effect


Scientific Papers found: Click to Expand⟱
7356- HibSad,    Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
AntiCan↑, Apoptosis↑, selectivity↑, ChemoSen↑, ROS↑, MMP↓, eff↑,
7454- HNK,    Updated progression of honokiol in lung cancer treatment
- Review, Lung, NA
AntiCan↑, eff↑,
7455- HNK,    Honokiol in cancer: Roles in enhancing combination therapy efficacy and preventing post-transplant malignancies
- Review, Var, NA
ChemoSen↑, Imm↝, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiCan↑, *Inflam↓, *antiOx↑, Synergy↑, *TNF-α↓, *IL1?, *IL6?,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
2082- HNK,    Revealing the role of honokiol in human glioma cells by RNA-seq analysis
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
AntiCan↑, TumCP↑, TumAuto↑, Apoptosis↑, *BioAv↑, *neuroP↑, *NF-kB↑, MAPK↑, GPx4↑, Tf↑, BAX↑, Bcl-2↓, antiOx↑, Hif1a↓, Ferroptosis↑,
4523- HNK,  MAG,  BA,    Honokiol-Magnolol-Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti-PD-1 Immunotherapy in Colorectal Cancer by Triggering GSDME-Dependent Pyroptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, LoVo - in-vivo, CRC, HCT116
AntiCan↑, eff↑, TumCP↓, TumCCA↓, cycD1/CCND1↓, Pyro↑, Apoptosis↑, cl‑GSDME↑, Bcl-2↓, Cyt‑c↑, Casp9↑, TumCG↓,
4522- HNK,  MAG,    Honokiol Is More Potent than Magnolol in Reducing Head and Neck Cancer Cell Growth
- in-vitro, HNSCC, FaDu
AntiCan↑, tumCV↓, eff↑, survivin↓, RadioS↑,
7371- HOO,    Phytochemical characterization of peanut oil and its ozonized form to explore biological activities in vitro
- in-vitro, Colon, NA
Dose↝, AntiBio↑, antiOx↑, AntiCan↑, selectivity↑,
7472- Hops,    Modulation of breast cancer cell survival by aromatase inhibiting hop (Humulus lupulus L.) flavonoids
- in-vitro, BC, SkBr3
CYP19↓, TumCP↓, Apoptosis↑, AntiCan↑,
7528- HT,    Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity
- in-vitro, AML, Jurkat - in-vitro, AML, HL-60 - in-vitro, NA, 1-
*antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, AntiCan↑, TumCCA↑, PI3K↓, MAPK↑, ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, p‑P53↓,
4634- HT,    Hydroxytyrosol in cancer research: recent and historical insights on discoveries and mechanisms of action
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, chemoP↑,
4633- HT,    Unlocking the effective alliance of β-lapachone and hydroxytyrosol against triple-negative breast cancer cells
- in-vitro, BC, NA
AntiCan↑, CSCs↓, antiOx↑, NQO1↑, TumCCA↑, ER Stress↑, Apoptosis↑, UPR↑,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7550- HYP,    Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway
- in-vitro, BC, MCF7 - in-vitro, BC, 4T1
*Inflam↓, AntiCan↑, tumCV↓, TumCMig↓, Apoptosis↑, Bcl-2↓, XIAP↓, BAX↑, cl‑Casp3↑, ROS↓, NF-kB↓, TumVol↓,
7552- HYP,    Hyperoside exerts potent anticancer activity in skin cancer
- vitro+vivo, Melanoma, NA
AntiCan↑, *Inflam↓, *antiOx↑, PI3K↓, Akt↓, mTOR↓, TumCP↓, Apoptosis↑, TumAuto↑, chemoPv↑,
7609- I3C,    Molecular Targets, Anti-cancer Properties and Potency of Synthetic Indole-3-carbinol Derivatives
- Review, Var, NA
AntiCan↑, tumCV↓, HIF-1↓, NF-kB↓, IGF-1↓, PI3K↓, Akt↓, Wnt↓, EstroRS/ERS↓,
7385- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- vitro+vivo, Lung, A549 - in-vitro, BC, 4T1
Apoptosis↑, necrosis↑, ROS↑, mtDam↑, Ca+2↑, MPT↑, MMP↓, AntiCan↑, *AntiBio↑, *Inflam↓, *antiOx↓, *neuroP↑, p‑Akt↓, DHODH↓, Diff↑, MAPK↑,
7801- IBC,    Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter
- in-vitro, CRC, HT-29
PSEN2/PS-2↓, AntiCan↑, Apoptosis↑, Akt↓, ERK↓, *antiOx↑, *Inflam↓, *neuroP↑, *toxicity↓, selectivity↑,
7769- IBC,    Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters
- in-vivo, Var, NA
*AntiCan↑, *AntiAg↑, *AntiFungal↑, CYP2C9↓, UGT1A↓, CYP2D6↓, CYP2E1↓,
7630- Ins,    Modulation of both Insulin Resistance and Cancer Growth by Inositol
- Review, Var, NA - Review, Diabetic, NA
*IRes↓, *AntiDiabetic↑, *glucose↝, AntiCan↑, PI3K↓, Akt↓, Glycolysis↓, STK11/LKB1↑, *FASN↓, *LDL↓, *FFA/NEFA↓, *ROS↓, ROS↑, IGF-1↓,
7629- Ins,    Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol
- in-vivo, Lung, NA
AntiCan↑, TumVol↓, PI3K↓, IL6↓, p‑STAT3↓, chemoPv↑,
7648- Ins,    Suppression of lung and liver carcinogenesis in mice by oral administration of myo-inositol
- in-vivo, Liver, NA
AntiCan↑, Dose↝, Risk↓, chemoPv↑,
7639- Ins,    Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells
- in-vitro, Nor, MCF10
EMT↓, E-cadherin↑, AntiCan↑, MMP9↓,
7641- Ins,    Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis
- Review, CRC, NA
AntiCan↑, p‑Akt↓, TF-Ag↓, *PI3K↓, *AP-1↓, *DNArepair↑, *BioAv↑, *BBB↑, *other↑, *PGE2↓,
7632- Ins,    The paradoxical role of inositol in cancer: a consequence of the metabolic state of a tumor
- Review, Var, NA
AMPK↑, AntiCan⇅, p‑Akt↓, PI3K↓,
7677- iod,    Activation of peroxisome proliferator-activated receptor gamma is crucial for antitumoral effects of 6-iodolactone
- in-vitro, BC, MCF7
TumCP↓, 6IL↑, PPARγ↑, AntiCan↑,
7682- iod,    Molecular Iodine Induces Anti- and Pro-Neoplastic Effects in Prostate Cancer Models
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
PPARγ↑, antiNeop↑, TumCD↑, TumCI↓, AntiCan⇅, antiOx↑, Inflam↓, Apoptosis↑, tumCV↓,
7728- IP6,    G0/G1 arrest and S phase inhibition of human cancer cell lines by inositol hexaphosphate (IP6)
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HT-29
AntiCan↑, TumCCA↑, Ki-67↓, PCNA↓,
7723- IP6,    Prostate cancer and inositol hexaphosphate: efficacy and mechanisms
- Review, Pca, NA
toxicity↓, AntiCan↑, TumCG↓, TumCCA↑, angioG↓,
7726- IP6,    Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation
- in-vitro, BC, MCF7
AntiCan↑, PKCδ↑, ERK↓, Akt↓, p27/CDKN1B↑, p‑pRB↓,
7695- IP6,    The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1β-stimulated colon cancer cells
- in-vitro, Colon, Caco-2
AntiCan↑, TumCA↓, TumCMig↓, MMP13↓, MMP3↓, MMP2↓, TIMP1↓, MMP1↓, MMP9↓, TIMP2↓,
7642- IP6,    Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway
- in-vitro, CRC, NA
AntiCan↑, TumCP↓, Apoptosis↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, AKT1↓, S6K↓, mTOR↓,
7645- IP6,  Ins,    Anticancer Properties of Inositol Hexaphosphate and Inositol: An Overview
- in-vitro, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, Diff↑, p27/CDKN1B↓, pRB↓, PI3K↓, RAS↓, ERK↓, Akt↓, NF-kB↓, Inflam↓, AntiTum↓,
7690- IP6,  Ins,    Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application
- Review, Colon, NA
AntiCan↑, Imm↑, antiOx↑, TumCP↓, Diff↑, TumCG↓, Synergy↑, P21↓, p27/CDKN1B↓, pRB↓, TumCCA↑, PI3K↓, Akt↓, PKCδ↓, RAS↓, ERK↓, NF-kB↓, Inflam↓, MMP9↓, IronCh↑, NK cell↑, selectivity↑, ChemoSen↑, chemoP↑, toxicity↓, Remission↑,
7696- IP6,  Ins,    The Combination of Inositol Hexaphosphate and Inositol Inhibits Metastasis of Colorectal Cancer Cells by Upregulating Claudin 7
- vitro+vivo, Colon, SW48 - in-vitro, Colon, SW-620
AntiCan↑, CLDN7↑, EMT↓, E-cadherin↑, N-cadherin↓, Synergy↑, TumCG↓,
7701- IP6,    Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway
- vitro+vivo, HCC, Hep3B - NA, NA, MHCC-97H
AntiCan↑, ChemoSen↑, LRP6↓, Wnt↓, β-catenin/ZEB1↓, CCN2/CTGF↓, ABCG1↓, TumCP↓, TumCMig↓,
7750- ISL,    Isoliquiritigenin in Breast Cancer: A Systematic Review of Its Preventive and Anti-metastatic Mechanisms
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumAuto↑, mTOR↓, AApath↓, EMT↓, BRCA1↝, PI3K↓, Akt↓, angioG↓, VEGF↓, Hif1a↓, COX2/PTGS2↓, NF-kB↓,
7745- ISL,    Isoliquiritigenin inhibits colorectal cancer progression by targeting the FGFR4/FASN mediated lipid metabolism pathway
- in-vitro, CRC, NA
AntiCan↑, TumCP↓, TumCMig↓, FASN↓, FGFR4/CD334↓, PI3K↓, Akt↓,
7746- ISL,    Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, HCT116
AntiCan↑, tumCV↓, Apoptosis↑, TumCCA↑, TumCG↓, PI3K↓, Akt↓, p‑Akt↓, p‑GSK‐3β↓, CDK1↓, NF-kB↓, Bcl-2↓, ERβ/ESR2↑, BAX↑, Bax:Bcl2↑, ROS↑,
7756- ISL,    Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, MDA-MB-231
AntiCan↑, VEGF↓, TumCI↓, TumCMig↓, Hif1a↓, TumCG↓, angioG↓, VEGFR2/KDR/Flk1↓, Apoptosis↑, toxicity↓, TumCCA↑, Inflam↓, ROS↑,
7763- ISL,    Harnessing Liquiritigenin: A Flavonoid-Based Approach for the Prevention and Treatment of Cancer
- Review, Var, NA
AntiCan↑, *antiOx↓, *Inflam↓, TumCP↓, Apoptosis↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, *AntiArt↑, Casp8↑, Cyt‑c↑, Casp↑, cl‑PARP↑, GutMicro↑, BioAv↑, BioAv↓, Half-Life↓,
7765- ISL,    Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications
- Review, Var, NA
*antiOx↑, *AntiCan↑, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *NRF2↑, *NQO1↝, *HO-1↑, *SOD↑, *toxicity↓, *BioAv↓, *Half-Life↓, *BBB↑, *neuroP↑, *Stroke↓, *GSK‐3β↓, *p‑GSK‐3β↑, *hepatoP↑, *Inflam↓, *ROS↓, *MPO↓, *MDA↓,
7868- isoO,    Isoorientin Suppresses Invasion of Breast and Colon Cancer Cells by Inhibition of CXC Chemokine Receptor 4 Expression
- in-vitro, BC, NA - in-vitro, CRC, NA
*antiOx↑, *AntiCan↑, *Inflam↓, CXCR4↓, NF-kB↓,
7814- ISQ,    Isoquercitrin Attenuates Steatohepatitis by Inhibition of the Activated NLRP3 Inflammasome through HSP90
- in-vivo, Nor, NA
*ROS↓, *AntiCan↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *HSP90↓, *AST↓, *ALAT↓, *antiAll↑,
7800- ISQ,    Isoquercitrin Attenuates Oxidative Liver Damage Through AMPK-YAP Signaling: An Integrative In Silico, In Vitro, and In Vivo Study
- vitro+vivo, Nor, HepG2
*antiOx↑, *Inflam↓, *AntiCan↑, *ROS↓, *MMP↑, *STK11/LKB1↑, *AMPK↑, *p‑AMPK↑, *ACC↑, *ALAT↓, *AST↓, *hepatoP↑,
9173- ITCs,  SFN,    Dietary isothiocyanates and anticancer agents: exploring synergism for improved cancer management
- Review, Var, NA
Synergy↑, AntiCan↑, chemoP↑, ChemoSen?, toxicity↓, ROS↑, NRF2↑, NF-kB↓, CYP1A1↓, CYP1A2↓, CYP1B1↓, TumCCA↑, PI3K↓, Akt↓, mTOR↓, PTEN↑, BAX↑, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Dose↝, Synergy↑,
9193- ITCs,  PEITC,  BITC,  SFN,    Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research
- Review, Var, NA
Risk↓, TumCCA↑, TumCD↑, selectivity↑, TumCP↓, angioG↓, EMT↓, CSCs↓, NF-kB↓, NOTCH↑, BioAv↑, AntiCan↑, Synergy↑, Polyps↓, ROS↑, compIII↓, ChemoSen↑, RadioS↑, *p‑4E-BP1↓,
8001- itraC,    Repurposing itraconazole as an anticancer agent
- Review, Var, NA
*AntiFungal↑, AntiCan↑, P-gp/ABCB1↓, HH↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, angioG↓, LymphAG↓, ChemoSen↑, OS↑, Gli1↓, Ki-67↓, CSCs↓,
8035- IVM,    Ivermectin and non-parasitic disorders: An update
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*AntiP↑, angioG↓, *AntiCan↓, mtDam↑, Apoptosis↑, necrosis↑, TumAuto↑, ROS↑, *neuroP↑, *Stroke↝, *cardioP↑,
8049- IVM,    Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer
- vitro+vivo, BC, NA
*AntiP↑, AntiCan↑, AntiTum↑, PAK1↓, p‑Akt↓, Akt↓, mTOR↓, TumCG↓,

Showing Research Papers: 251 to 300 of 491
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 491

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 23,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 3,   Catalase↑, 3,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 10,   GPx4↑, 1,   GSH↓, 24,   GSH↑, 3,   GSH↝, 1,   GSH∅, 1,   GSH/GSSG↓, 1,   GSTs↑, 4,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 3,   HO-1↑, 1,   HO-2↑, 1,   Iron↓, 1,   Iron↑, 5,   i-Iron↑, 3,   c-Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 11,   MDA↓, 2,   MDA↑, 3,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 10,   NRF2↑, 11,   NRF2↝, 1,   Prx↓, 2,   PrxI↓, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 25,   ROS↑, 167,   ROS⇅, 3,   ROS↝, 2,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   selenoP↓, 1,   SOD↓, 6,   SOD↑, 4,   TAC↓, 1,   TBARS↑, 1,   Thiols↓, 3,   Trx↓, 2,   TrxR↓, 4,   TrxR1↓, 3,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   Mets↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 2,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 4,   compI↓, 1,   compII↓, 1,   compIII↓, 1,   EGF↓, 1,   ETC?, 1,   ETC↓, 3,   HSP60/HSPD1↓, 1,   Insulin↓, 2,   mtDam↑, 12,   OCR↓, 6,   OXPHOS↝, 1,   mt-OXPHOS↑, 1,   PDH↑, 2,   PDH↝, 1,   PHB↓, 1,   SIRT3↑, 1,   TrxR2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 2,   AApath↓, 1,   ACC↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   Alanine↓, 1,   ALAT↓, 2,   AMPK↑, 9,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 11,   i-ATP↓, 1,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   CRM↑, 1,   DHCR24↓, 1,   DHODH↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   GAPDH↓, 1,   glucose↓, 2,   GlucoseCon↓, 2,   GlucoseCon∅, 1,   GlutMet↓, 1,   Glycine↓, 1,   Glycolysis↓, 14,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 1,   H2S↑, 1,   Histones↑, 1,   HK2↓, 5,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 2,   lactateProd∅, 1,   LDHA↓, 3,   LDL↓, 1,   NAD↓, 1,   NADPH↓, 3,   NADPH↑, 2,   PDK1 / PDPK1↓, 2,   PDKs↓, 1,   PFK↓, 1,   PKM2↓, 8,   PLA2↓, 1,   polyA↓, 1,   SIRT1↓, 6,   SIRT1↑, 6,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   TS↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 2,   Apoptosis?, 2,   Apoptosis↓, 2,   Apoptosis↑, 182,   mt-Apoptosis↑, 2,   BAD↓, 3,   BAD↑, 5,   Bak↓, 1,   Bak↑, 7,   BAX↓, 1,   BAX↑, 71,   Bax:Bcl2↑, 15,   Bcl-2↓, 78,   Bcl-2↑, 1,   Bcl-xL↓, 11,   Bcl-xL↑, 1,   BID↓, 1,   BID↑, 3,   p‑BID↓, 1,   BIM↑, 1,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 24,   Casp↝, 1,   Casp12↑, 2,   Casp12↝, 1,   Casp3↓, 3,   Casp3↑, 75,   cl‑Casp3↑, 15,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp7↑, 11,   cl‑Casp7↑, 2,   Casp8↑, 21,   Casp8∅, 1,   cl‑Casp8↑, 1,   Casp9↑, 51,   p‑Casp9↑, 1,   cl‑Casp9↑, 5,   CellShr↑, 1,   cFLIP↓, 2,   Cyt‑c↑, 51,   Diablo↑, 2,   DIDO1/DIO-1↑, 1,   DR5↑, 9,   FADD↑, 3,   Fas?, 1,   Fas↓, 2,   Fas↑, 12,   FasL↑, 5,   Ferroptosis↑, 10,   GRP58↓, 1,   cl‑GSDME↑, 1,   GSDME-N↑, 1,   IAP1↓, 3,   iNOS↓, 5,   iNOS↑, 1,   Mcl-1↓, 4,   p‑Mcl-1↓, 1,   MDM2↓, 3,   MDM2↑, 1,   MOMP↑, 4,   Necroptosis↑, 3,   necrosis↑, 5,   p38↓, 2,   p38↑, 9,   p‑p38↓, 2,   p‑p38↑, 2,   pS2/TFF1↓, 1,   PUMA↓, 1,   PUMA↑, 3,   Pyro↑, 2,   RIP3↓, 1,   survivin↓, 21,   TRAIL↑, 3,   TumCD↓, 1,   TumCD↑, 16,   XIAP↓, 13,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 82,   Akt↑, 3,   p‑Akt↓, 17,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 1,   CIP2A↓, 2,   CK2↓, 2,   CREB↓, 1,   EGFR↓, 18,   EGFR↑, 1,   ERK↓, 33,   ERK↑, 4,   p‑ERK↓, 7,   FGFR1↓, 1,   FGFR4/CD334↓, 1,   FOXD3↑, 1,   HCAR2↑, 2,   HER2/EBBR2↓, 10,   HGF/c-Met↓, 1,   Hippo↑, 1,   IGF-1R↓, 2,   IGFR↓, 1,   IKKα↓, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 8,   JAK3↓, 1,   JNK↓, 1,   JNK↑, 8,   p‑JNK↑, 3,   MAPK↓, 22,   MAPK↑, 11,   MARK4↓, 1,   MEK↓, 2,   MKP1↝, 1,   mTOR↓, 43,   p‑mTOR↓, 7,   mTORC2↓, 1,   p70S6↓, 1,   P70S6K↓, 2,   PDE3B↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 69,   PI3K↑, 2,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PI3K/Akt↑, 1,   PIK3CA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 7,   PKCδ↑, 1,   PTEN↓, 2,   PTEN↑, 10,   Raf↓, 1,   RAS↓, 6,   Rictor↓, 1,   RIP1↓, 1,   S6K↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 2,   Src↓, 1,   STAT↓, 2,   STAT3↓, 36,   STAT3↑, 3,   p‑STAT3↓, 3,   STAT5↓, 1,   STAT6↓, 1,   STK11/LKB1↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   ATF2↓, 2,   ATF4↑, 1,   CBP↓, 1,   ChrMod↑, 1,   cJun↓, 1,   cMyc↓, 16,   cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 6,   EZH2↓, 3,   FOXM1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO3↝, 1,   p‑H3↓, 1,   ac‑H3↑, 2,   ac‑H4↑, 2,   HATs↓, 2,   HATs↑, 1,   HDAC↓, 15,   HDAC1↓, 6,   HDAC2↓, 3,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 4,   miR-106b↓, 1,   miR-155↓, 1,   miR-199↓, 1,   miR-200b↑, 2,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-30a-5p↑, 1,   miR-34a↓, 1,   miR-34a↑, 4,   miR-590-3p↑, 1,   MTA2↓, 1,   Myc↓, 3,   OCT4↓, 6,   other↓, 5,   other↑, 5,   other↝, 18,   other∅, 1,   PCAF↓, 1,   PhotoS↑, 1,   SOX2↓, 3,   SOX4↓, 1,   SOX9↓, 1,   TLE1↓, 1,   tumCV?, 2,   tumCV↓, 41,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 7,   eIF2α↑, 1,   ER Stress↑, 22,   ERStress↑, 1,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 6,   HTRA↓, 1,   PERK↑, 1,   PSMB5↓, 1,   UPR↑, 4,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 5,   LC3B↑, 1,   LC3B-II↑, 1,   LC3II↑, 10,   LC3s↑, 1,   p62↓, 4,   p62↑, 4,   TumAuto↓, 3,   TumAuto↑, 42,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   BRCA1↓, 1,   BRCA1↑, 2,   BRCA1↝, 1,   p‑BRCA1↑, 1,   DFF45↓, 1,   DNAdam↓, 3,   DNAdam↑, 49,   DNArepair↓, 1,   DNArepair↑, 2,   hTERT/TERT↓, 3,   p16↑, 2,   P53↓, 1,   P53↑, 42,   P53↝, 1,   p‑P53↓, 2,   p‑P53↑, 2,   PARP↑, 9,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 32,   PARP1↑, 2,   cl‑PARP1↑, 3,   PCNA↓, 18,   Telomerase↓, 8,   TOP1↓, 7,   TOP2↓, 3,   TOP2↑, 1,   TP53↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 5,   CDK1↑, 1,   CDK2↓, 12,   CDK2↑, 2,   CDK4↓, 26,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 6,   CDKN1C/p57↓, 1,   cellSen↑, 1,   CHK1↓, 1,   CHK1↑, 2,   Chk2↑, 2,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 10,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 34,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 9,   cycE/CCNE↑, 2,   E2Fs↓, 2,   GADD34↑, 1,   Ki-67↓, 12,   MAD↓, 1,   mitA↑, 1,   p19↑, 1,   P21↓, 4,   P21↑, 33,   p27/CDKN1B↓, 5,   p27/CDKN1B↑, 18,   pRB↓, 3,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 2,   TumCCA?, 1,   TumCCA↓, 2,   TumCCA↑, 141,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH↓, 2,   ALDH1A1↓, 1,   cFos↓, 3,   CSCs?, 1,   CSCs↓, 19,   CSCs↑, 1,   CSCsMark↓, 1,   Diff↑, 4,   EIF4E↓, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 12,   IGFBP3↑, 1,   Ki-67↓, 12,   Let-7↑, 2,   LRP6↓, 1,   mTORC1↓, 2,   Nanog↓, 2,   NOTCH↓, 9,   NOTCH↑, 1,   NOTCH1↓, 7,   NOTCH3↓, 1,   p300↓, 2,   Shh↓, 1,   Smo↓, 1,   TumCG↓, 68,   TumCG↑, 3,   TumCP↓, 110,   TumCP↑, 3,   Wnt↓, 22,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↓, 1,   AP-1↓, 3,   AP-1↑, 1,   ATPase↓, 1,   CA↓, 1,   Ca+2↓, 2,   Ca+2↑, 17,   Ca+2↝, 2,   Cal9↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   CTNNB1↓, 1,   E-cadherin↑, 23,   EMT↓, 30,   EMT↑, 1,   EpCAM↓, 3,   FAK↓, 9,   FAK↑, 1,   p‑FAK↓, 2,   hnRNPA1↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   LIMK2↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MMP1↓, 5,   MMP13↓, 3,   MMP2↓, 44,   MMP3↓, 5,   MMP7↓, 3,   MMP9↓, 55,   MMP9↑, 1,   MMPs↓, 12,   MTA1↓, 1,   N-cadherin↓, 11,   NFAT↑, 1,   PAK1↓, 1,   PDGF↓, 3,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 2,   Slug↓, 2,   Smad1↓, 2,   SMAD4↓, 2,   Snail↓, 6,   TET1↑, 1,   TGF-β↓, 11,   TGF-β↑, 1,   TGF-β1↓, 2,   TIMP1↓, 2,   TIMP1↑, 6,   TIMP2↓, 3,   TIMP2↑, 6,   TIMP3↑, 1,   TRIB3↑, 2,   TSP-1↑, 1,   TumCA↓, 5,   TumCI↓, 46,   TumCMig↓, 56,   TumCMig↑, 2,   TumMeta↓, 55,   TumMeta↑, 4,   Twist↓, 6,   TXNIP↑, 1,   uPA↓, 7,   uPAR↓, 1,   Vim↓, 13,   Zeb1↓, 5,   ZEB2↓, 2,   α-tubulin↓, 3,   β-catenin/ZEB1↓, 27,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 78,   angioG↑, 2,   CD31/PECAM-1↓, 1,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 5,   Hif1a↓, 34,   LOX1↓, 2,   LymphAG↓, 1,   NO↓, 2,   PHDs↓, 1,   VEGF↓, 49,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 7,  

Barriers & Transport(tgid=15) ⓘ

ABCG1↓, 1,   AQPs↓, 1,   BBB↑, 3,   CellMemb↓, 1,   CellMemb↑, 2,   CLDN1↑, 1,   CLDN2↓, 1,   CLDN7↑, 1,   EPR↑, 6,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT3↑, 1,   IBI↑, 1,   KCNH2/hERG↓, 1,   LAT↓, 1,   MMP↓, 73,   MMP↑, 3,   MPT↑, 3,   NHE1↓, 1,   OCLN↑, 1,   SLC12A5↓, 1,   SVCT-2↝, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   CD14↓, 1,   CD4+↓, 1,   CD4+↑, 3,   CD44↓, 6,   CD59↑, 1,   CD8+↑, 4,   p‑cDC2↓, 1,   COX2/PTGS2↓, 40,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CXCL12↓, 1,   CXCR4↓, 5,   DCells↑, 1,   Dectin1↝, 1,   DR4↑, 4,   FOXP3↓, 1,   HCAR2↑, 2,   HMGB1↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 3,   Igs↓, 1,   IL1↓, 3,   IL10↓, 3,   IL10↑, 2,   IL12↑, 2,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 7,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL4↑, 2,   IL5↓, 1,   IL6↓, 22,   IL8↓, 7,   Imm↑, 12,   Imm↝, 2,   INF-γ↓, 1,   INF-γ↑, 1,   Inflam↓, 36,   Inflam↝, 1,   IRAK1↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MCT1↓, 1,   MIP-1β↑, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 79,   NF-kB↑, 5,   p‑NF-kB↓, 1,   NK cell↑, 10,   NLRP3↓, 1,   NLRP3↑, 1,   p65↓, 1,   ac‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 5,   PGE2↓, 10,   PSA↓, 11,   PSA∅, 1,   T-Cell↑, 1,   Th1 response↑, 2,   Th2↑, 1,   TLR4↓, 4,   TNF-α↓, 15,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,   e-pH↑, 1,   i-pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN2/PS-2↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↓, 1,   AR↓, 7,   CYP19↓, 2,   ERα/ESR1↓, 1,   ERβ/ESR2↑, 1,   EstroRS/ERS↓, 1,   GR↑, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 5,   RANKL↓, 2,   SRC3↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 36,   BioAv↑, 42,   BioAv⇅, 1,   BioAv↝, 10,   BioEnh↑, 3,   ChemoSen?, 1,   ChemoSen↓, 3,   ChemoSen↑, 124,   ChemoSen⇅, 1,   ChemoSen↝, 1,   ChemoSen∅, 2,   CompStab?, 1,   CompStab↑, 2,   CompStab↝, 3,   CYP1A1↓, 4,   CYP1A1↑, 2,   CYP1A2↓, 2,   CYP1A2↑, 1,   CYP1B1↓, 1,   CYP2A3/CYP2A6↓, 1,   CYP2C9↓, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   CYP2E1↑, 1,   CYP3A2↓, 1,   CYP3A4↓, 3,   Dose?, 5,   Dose↓, 1,   Dose↑, 6,   Dose↝, 47,   Dose∅, 11,   eff↓, 26,   eff↑, 75,   eff↝, 12,   eff∅, 3,   GSTM1↑, 1,   Half-Life↓, 7,   Half-Life↑, 1,   Half-Life↝, 4,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 13,   P-gp/ABCB1⇅, 1,   P450↓, 2,   RadioS↓, 1,   RadioS↑, 28,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 65,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 67,   UGT1A↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   AR↓, 7,   ascitic↓, 1,   BG↓, 1,   BRCA1↓, 1,   BRCA1↑, 2,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CEA↓, 1,   CIT↓, 1,   CRP↓, 2,   EGFR↓, 18,   EGFR↑, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   EZH2↓, 3,   Ferritin↓, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 10,   hTERT/TERT↓, 3,   IL6↓, 22,   LDH↓, 6,   LDH↑, 1,   LDH↝, 1,   Maspin↑, 1,   Myc↓, 3,   PD-L1↓, 5,   Polyps↓, 2,   PSA↓, 11,   PSA∅, 1,   TF-Ag↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan?, 1,   AntiCan↓, 11,   AntiCan↑, 368,   AntiCan⇅, 2,   AntiCan↝, 1,   AntiCan?, 1,   AntiCan∅, 3,   AntiDiabetic↑, 1,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 16,   APG↓, 1,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 10,   CardioT↓, 1,   chemoP↑, 31,   chemoPv↑, 23,   ChemoSideEff↓, 6,   cognitive↑, 1,   FTO↓, 1,   hepatoP↑, 9,   neuroP↑, 5,   Obesity↓, 1,   OS↑, 9,   OS⇅, 1,   Pain↓, 4,   Pin1↓, 1,   QoL↑, 4,   radioP↑, 7,   Remission↑, 2,   RenoP↑, 4,   Risk↓, 30,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 18,   toxicity↑, 3,   toxicity⇅, 1,   toxicity↝, 9,   toxicity∅, 2,   TumNum↓, 1,   TumVol↓, 17,   TumW↓, 7,   Weight↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiViral↑, 1,   Bacteria↓, 2,   Dectin1↝, 1,   GutMicro↑, 6,   GutMicro↝, 2,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 4,  
Total Targets: 832

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 10,   antiOx↑, 150,   ARE↑, 1,   Catalase↑, 40,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 30,   GPx1↑, 2,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 34,   GSR↑, 6,   GSTs↓, 1,   GSTs↑, 12,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 2,   HDL∅, 1,   HO-1↓, 1,   HO-1↑, 16,   HO-1⇅, 1,   hyperG↓, 2,   hyperG↝, 1,   Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   lipid-P↓, 33,   MDA↓, 26,   MDA↑, 2,   MPO↓, 5,   NOX↓, 1,   NQO1↑, 3,   NQO1↝, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 38,   Prx↑, 1,   RNS↓, 2,   ROS?, 1,   ROS↓, 109,   ROS↑, 2,   mt-ROS↓, 1,   SAM-e↑, 1,   selenoP↑, 4,   SOD↑, 50,   mt-SOD↑, 1,   SOD1↑, 6,   SOD2↑, 2,   TAC↑, 3,   TBARS↓, 3,   Trx↑, 1,   uricA↓, 2,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 6,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 2,   Insulin↑, 2,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 1,   PGC-1α↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   5-HETE↓, 1,   5LO↓, 3,   ACC↓, 1,   ACC↑, 1,   Acetyl-CoA↑, 1,   ALAT?, 1,   ALAT↓, 17,   ALAT∅, 1,   AMPK↓, 1,   AMPK↑, 7,   p‑AMPK↑, 2,   ATP↓, 1,   ATP↑, 4,   ATP↝, 1,   CRM↑, 2,   Eic↓, 1,   FASN↓, 2,   FFA/NEFA↓, 1,   glucose↓, 3,   glucose↝, 1,   GlucoseCon↑, 3,   glyC↓, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 1,   H2S↑, 2,   LDL↓, 11,   lipidLev↓, 2,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   SIRT1↑, 4,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 7,   Apoptosis↑, 1,   BAX↓, 8,   Bcl-2↓, 2,   Bcl-2↑, 4,   Casp3↓, 10,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   Casp9↓, 5,   Cyt‑c↓, 2,   Fas↓, 1,   Ferroptosis↓, 2,   GSDMD↓, 1,   iNOS↓, 15,   iNOS↑, 1,   necrosis↓, 1,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 4,   p‑Akt↓, 1,   Akt2↓, 1,   ERK↓, 2,   IGF-1R↓, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↑, 1,   JNK↓, 2,   JNK↑, 2,   MAPK↓, 8,   MAPK↑, 2,   mTOR↓, 4,   mTOR↑, 1,   p‑mTOR↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 4,   PI3K↑, 3,   PKCδ↑, 1,   PP2A↑, 1,   RIP1↓, 1,   STAT↓, 1,   STAT3↓, 2,   STAT3↑, 3,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   ATF4↓, 1,   cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   FOXO3↑, 1,   HATs↓, 2,   HDAC↓, 2,   HDAC2↓, 1,   other?, 1,   other↓, 4,   other↑, 4,   other↝, 20,   PhotoS↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 8,   DNArepair↑, 1,   P53↓, 3,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   GADD45A↑, 1,   Ki-67↓, 1,   P21↓, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   BMPs↑, 1,   EP300↓, 1,   GH↑, 1,   HH↓, 1,   Ki-67↓, 1,   mTORC1↓, 1,   neuroG↑, 4,   TumCP↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 10,   AP-1↓, 4,   Ca+2↓, 2,   Ca+2↑, 1,   Ca+2↝, 3,   Ca+2∅, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 1,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 4,   PAI-1/SERPINE1↓, 1,   ROCK1↓, 1,   serineP↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TIMP1↓, 1,   TumCI↓, 1,   Vim↓, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

eNOS↑, 2,   Hif1a↓, 1,   NO↓, 9,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 4,   BBB↑, 9,   GastroP↑, 4,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   IBI↑, 2,   MMP↑, 7,   OCLN↝, 1,   TJ↑, 1,   TRPM7↓, 1,   TRPV1↑, 3,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD19↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 25,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 4,   IL1?, 1,   IL1↓, 2,   IL10↓, 3,   IL10↑, 3,   IL12↓, 4,   IL17↓, 4,   IL1β↓, 19,   IL22↓, 1,   IL23↓, 1,   IL6?, 1,   IL6↓, 27,   IL6↑, 1,   IL8↓, 6,   Imm↓, 1,   Imm↑, 22,   Imm⇅, 2,   Imm↝, 2,   Inflam?, 1,   Inflam↓, 173,   Inflam↑, 4,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 1,   MCP1/CCL2↓, 3,   MyD88↓, 1,   NF-kB?, 1,   NF-kB↓, 36,   NF-kB↑, 2,   NK cell↑, 2,   NLRP3↓, 3,   NLRP3↑, 1,   PGE2↓, 10,   PGE2↑, 1,   RANTES↓, 1,   TLR1↓, 1,   TLR2↓, 2,   TLR4↓, 4,   TNF-α↓, 40,   TNF-α↑, 1,   TRIF↓, 1,   VitD↑, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   Ach↑, 1,   AChE↓, 17,   ADAM10↑, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 5,   ChAT↑, 2,   NGF↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APOE4↓, 1,   APP↓, 1,   cl‑APP↑, 1,   Aβ↓, 18,   Aβ42↓, 1,   BACE/β-secretase↓, 8,   PSEN1/PS1↑, 1,   tau↓, 5,   p‑tau↓, 5,   XO↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   BNP↓, 1,   PPARγ↑, 2,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 35,   BioAv↑, 47,   BioAv⇅, 2,   BioAv↝, 22,   CompStab↓, 1,   CompStab↑, 4,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 21,   eff↑, 13,   eff↝, 3,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↝, 10,   Half-Life∅, 1,   P450↓, 2,   P450↑, 1,   selectivity↑, 2,   Synergy↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 17,   ALAT∅, 1,   ALB↑, 1,   ALP↓, 2,   AST↓, 18,   AST∅, 1,   BG↓, 2,   BloodF↑, 2,   BMD↑, 4,   BP↓, 11,   BUN↓, 3,   Calcium↑, 1,   colonLen↑, 1,   creat↓, 4,   CRP↓, 3,   HbA1c↓, 1,   HOMA↓, 1,   hs-CRP↓, 3,   IL6?, 1,   IL6↓, 27,   IL6↑, 1,   IRes↓, 1,   IRes↝, 1,   LDH↓, 6,   Mag↑, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 3,   AntiAge↑, 15,   antiAll?, 1,   antiAll↑, 14,   AntiArt↑, 13,   AntiCan?, 1,   AntiCan↓, 4,   AntiCan↑, 105,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 56,   antiM↑, 1,   antiPy↑, 1,   AntiTum↑, 3,   cardioP↓, 1,   cardioP↑, 64,   CardioT↓, 1,   chemoP↑, 9,   chemoPv↑, 5,   ChemoSideEff↓, 1,   cognitive↓, 1,   cognitive↑, 25,   cough?, 1,   diuretic↑, 3,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 60,   Learn↑, 1,   memory↑, 24,   Mood↑, 2,   motorD↑, 4,   neuroP?, 1,   neuroP↓, 1,   neuroP↑, 98,   NP/CIPN↓, 1,   Obesity↓, 15,   OS↑, 3,   Pain↓, 4,   QoL↑, 1,   radioP↑, 4,   RenoP↑, 14,   Risk↓, 1,   Sleep↑, 1,   SoreThr?, 1,   Stress↓, 1,   Stroke↓, 12,   Stroke↝, 1,   toxicity↓, 39,   toxicity↑, 3,   toxicity↝, 17,   toxicity∅, 6,   Weight↓, 4,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 29,   AntiFungal↓, 1,   AntiFungal↑, 11,   AntiP↑, 4,   AntiViral↑, 18,   Bacteria↓, 51,   Diar↓, 2,   GutMicro↑, 25,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↑, 5,   Ingr↝, 14,   Phen↑, 1,   QC↑, 1,  
Total Targets: 442

Scientific Paper Hit Count for: AntiCan, Anticancer Effect
19 Silver-NanoParticles
12 Lycopene
11 Selenium NanoParticles
10 Thymoquinone
10 phytic acid, Inositol hexakisphosphate
9 Emodin
9 Inositol
9 Sulforaphane (mainly Broccoli)
8 Capsaicin
8 Magnolol
8 Phenethyl isothiocyanate
8 Quercetin
7 Allicin (mainly Garlic)
7 Curcumin
7 Gambogic Acid
7 Kaempferol
6 Vitamin C (Ascorbic Acid)
6 Astaxanthin
6 Baicalein
6 Eugenol
6 Honokiol
6 Isoliquiritigenin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Artemisinin
5 EGCG (Epigallocatechin Gallate)
5 Lactoferrin/Talactoferrin
4 chitosan
4 Apigenin (mainly Parsley)
4 Boron
4 Carvacrol
4 Chlorogenic acid
4 Crocetin
4 Dandelion Root
4 Ferulic acid
4 Isovitexin
4 Licochalcone A
4 Licorice
4 Naringin
4 Selenium
3 Cisplatin
3 Melatonin
3 Aloe anthraquinones
3 beta-glucans
3 Biochanin A
3 Benzyl isothiocyanate
3 α-Bisabolol / Chamomile oil
3 Hydroxycinnamic-acid
3 Resveratrol
3 Spermidine
3 Carvone
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Cucurbitacin
3 Date Fruit Extract
3 Diindolylmethane
3 Indole-3-carbinol
3 Lemongrass Extract/Citral
3 Ellagic acid
3 flavonoids
3 Formononetin
3 Flaxseed/Linseed
3 Fucoidan
3 Gallic acid
3 Garcinol
3 Geraniol
3 Ginkgetin
3 HydroxyTyrosol
3 Hyperoside
3 Isobavachalcone
3 Luteolin
3 Matrine
3 Mung Bean Sprouts
3 Propolis -bee glue
3 Pterostilbene
3 salinomycin
3 Silymarin (Milk Thistle) silibinin
3 Vitamin D3
3 Vitamin K2
2 3-bromopyruvate
2 5-fluorouracil
2 Auranofin
2 doxorubicin
2 Alpha-Lipoic-Acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Anethole/trans-Anethole
2 Baicalin
2 Beta-Caryophyllene
2 Boswellia (frankincense)
2 Butyrate
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Chlorophyllin
2 Chrysin
2 Cinnamon
2 Camptothecin
2 Dichloroacetate
2 diet Fermented Foods
2 Ginkgo biloba-EGb 761
2 Flaxseed Oil
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 Hydrogen Gas
2 Hibiscus sabdariffa
2 iodine
2 isoquercitrin
2 Isothiocyanates
2 Ivermectin
2 Juglone
2 SDG/lignans
2 Vitexin
2 Magnetic Fields
2 Morin
2 Bicarbonate(Sodium)
2 Marjoram (Origanum majorana)
2 Purple Corn / Purple Maize
2 Phycocyanin
2 Piperine
2 Rosmarinic acid
2 Rauwolfia serpentina/Indian Snakeroot
2 Sesamin
2 Shikonin
2 Ursolic acid
2 Urolithin
2 VitK3,menadione
1 1,8-Cineole
1 Astragalus
1 Citric Acid
1 Allyl isothiocyanate
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Berberine
1 Betulinic acid
1 Bromelain
1 borneol
1 Black Rice, Oryza sativa
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 Vitamin B3,Niacin
1 Caffeic acid
1 Caffeine
1 urea
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chaetocin
1 Carica papaya leaf extract
1 irinotecan
1 Cranberry
1 Calorie Restriction Mimetics
1 Aspirin
1 Polyphenols
1 Chlorella (Chlorella vulgaris)
1 Diclofenac
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 diet Plant based
1 Ormeloxifene (Centchroman)
1 Electrical Pulses
1 Eurycomanone
1 Evodiamine
1 ferumoxytol
1 Fisetin
1 Paclitaxel/Taxol
1 Gamma-aminobutyric acid
1 Ginkgo biloba
1 Geldanamycin
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 alpha Linolenic acid
1 Graviola
1 Grapeseed extract
1 Germacranolide sesquiterpene lactone
1 Chemotherapy
1 High-Ozonide Oil
1 Hops (Humulus lupulus)
1 isoorientin
1 itraconazole
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Lecithin
1 Linalool
1 Lutein
1 Methylene blue
1 Photodynamic Therapy
1 mebendazole
1 methylseleninic acid
1 Metformin
1 Magnetic Field Rotating
1 Mangiferin
1 Methylglyoxal
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Oleocanthal
1 Oregano
1 Patchouli Oil (Pogostemon cablin)
1 Piperlongumine
1 Psoralidin
1 Parthenolide
1 Gold NanoParticles
1 Salvia officinalis
1 Radiotherapy/Radiation
1 α-Santalol/Sandalwood oil
1 Calcium
1 Terpenoids
1 Aflavin-3,3′-digallate
1 Magnesium
1 Zerumbone
1 Zyflamend
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:813  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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