Inflam Cancer Research Results

Inflam, inflammation: Click to Expand ⟱
Source:
Type:
Cancer and inflammation are closely linked, with chronic inflammation contributing to the development and progression of cancer. Various inflammatory mediators and cells are involved in this process.
Scientific Papers found: Click to Expand⟱
5890- CAR,    Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways
- Review, Var, NA
selectivity↑, TumCG↓, *Inflam↓, *antiOx↑, TumCCA↑, TumCMig↓, TumCI↓, angioG↓,
5927- CAR,    Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *motorD↑, *toxicity↓, *TRPV3↑, *other↓, *antiOx↑, *LDL↓, *COX2/PTGS2↓, *PPARα↑, *NO↓, *AChE↓, *eff↑, *SOD↑, *Catalase↑, *neuroP↑, *BioAv↝, *BBB↑, *BioAv↑, *CompStab↑,
5932- CAR,    Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
- in-vivo, IBD, NA - in-vivo, Park, NA
*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2/PTGS2↓, *IFN-γ↓, IL1β↓, ADAM10?,
5926- CAR,    An Updated Review of Research into Carvacrol and Its Biological Activities
- Review, Nor, NA - Review, AD, NA - Review, Asthma, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *toxicity↓, *Pain↓, *TRPV3↑, *NRF2↑, *Ca+2↑, *ATP↑, *5LO↓, *COX2/PTGS2↓, PGE2↓, *hepatoP↑, *AntiAg↑, *Diar↓, *cardioP↑, *other↝, *chemoPv↑, *cognitive↑, *AChE↓, *GastroP↑, *Synergy↑, *BChE↓, *CRP↓, *antiAll↑,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2/PTGS2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *Stroke↓, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2/KDR/Flk1↓, NF-kB↓,
3871- Carno,    Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper
- Review, Nor, NA
*ROS↓, *NO↓, *Inflam↓,
3872- Carno,    Carnosine Protects Macrophages against the Toxicity of Aβ1-42 Oligomers by Decreasing Oxidative Stress
- in-vitro, AD, NA
*antiOx↑, *Inflam↓, *Aβ↓, *neuroP↑, *ROS↓, *NO↓,
9143- Cast,    Chestnut (Castanea sativa Mill.) leaf extract and pure castalagin reduce bacterial colonisation and the associated inflammation in gastric organoids and a mouse model of H. pylori infection
- in-vivo, Nor, NA
*Inflam↓, *Bacteria↓, *NF-kB↓, *CXCR2↓, *CXCR3↓,
5914- Cats,    Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells
- in-vitro, AML, HL-60
*Inflam↓, eff↑, DNAdam↑, Cyt‑c↑, Casp3↑, PARP↑, Fas↑, proCasp8↑, cl‑BID↑, BAX↑, Bcl-xL↑, cl‑Mcl-1↑,
5913- Cats,    Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection
- Review, Nor, NA
*Inflam↓, *NF-kB↓, *DPPH↓, *TNF-α↓, *Imm↑,
5811- CBC,    The Potential of Cannabichromene (CBC) as a Therapeutic Agent
- Review, Var, NA
*eff?, *Half-Life↝, *Inflam↓,
6254- CBC/D,    Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
- Review, Var, NA
*neuroP↑, *Imm↑, *Inflam↓, CSCs↓, HH↓, Gli↓, AST↓, ALAT↓, MDA↓, hepatoP↑, *NRF2↑, *HO-1↑, NF-kB?, GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, MMP2↑, MMP9↓, BioAv↑,
9141- CC,    Camu Camu (Myrciaria dubia (Kunth) McVaugh): An Amazonian Fruit with Biofunctional Properties–A Review
- Review, Nor, NA
*Ingr↝, *antiOx↑, *hyperG↓, *Obesity↓, *QoL↓, *AntiBio↑, *Inflam↓, *TumCP↓, *hepatoP↑, *Ingr↝, *eff↝, *antiAll↑, *AntiTum↑, *NRF2↑, *NQO1↑, *NA↑,
9139- CC,    Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice
- in-vivo, Obesity, NA
*antiOx↑, *Inflam↓, *Obesity↓, *hepatoP↑, *GutMicro↑,
9138- CC,    Tropical fruit camu-camu (Myrciaria dubia) has anti-oxidative and anti-inflammatory properties
- Study, Nor, NA
*Ingr↝, *Dose?, *8-oxo-dG↓, *ROS↓, *Inflam↓, *CRP↓, *IL6?, *IL8?, *eff↑, *antiOx↑,
5964- CEL,    Celecoxib pathways: pharmacokinetics and pharmacodynamics
- Review, Var, NA
COX2/PTGS2↓, *Pain↓, *Inflam↓, Apoptosis↑, TumCCA↑, angioG↓, ER Stress↑, VEGF↓, MMP9↓, PDK1 / PDPK1↓, Akt↓, CA↓, CardioT↑,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2/PTGS2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
5938- Cela,    Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
- Review, Var, NA
AntiCan↑, BioAv↓, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, angioG↓, Inflam↓, antiOx↑, ChemoSen↑, HSP90↓, ROS↑, RadioS↑, P53↑, NLRP3↓, CompStab?,
5941- Cela,    Celastrol inhibits migration and invasion through blocking the NF-κB pathway in ovarian cancer cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, OVCAR-3
TumCMig↓, TumCI↓, NF-kB↓, p65↓, MMP9↓, eff↑, AntiTum↑, Inflam↓, AntiDiabetic↑,
5952- Cela,    Celastrol attenuates Alzheimer’s disease-mediated learning and memory impairment by inhibiting endoplasmic reticulum stress-induced inflammation and oxidative stress
- in-vivo, AD, NA
*memory↑, *Inflam↓, *ROS↓, *ER Stress↓, *neuroP↑, *Dose↝, *MDA↓, *SOD↑, *Catalase↑, *Aβ↓, BACE/β-secretase↓, LRP1↑, RAGE↓,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
- Review, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP/DDIT3↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
2393- Cela,    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- in-vivo, Sepsis, NA - in-vitro, Nor, RAW264.7
OS↑, PKM2↓, Glycolysis↓, Warburg↓, Inflam↓, HMGB1↓, ALAT↓, AST↓, TNF-α↓, IL1β↓, IL6↓,
6662- Cen,    Assessment report on Centella asiatica (L.) Urban, herba
- Review, Nor, NA
*cognitive↑, *Inflam↓, *AntiBio↑, *Imm↑, *antiOx↑, *Wound Healing↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *MDA↓, *lipid-P↓, *ROS↓, *memory↑, *GABA↑, *antiPs↑, *BioAv↝,
6656- Cen,    Recent insights into therapeutic potential and nanostructured carrier systems of Centella asiatica: An evidence-based review
- Review, Var, NA - Review, AD, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *antiOx↑, *cardioP↑, *Inflam↓, *hepatoP↑, *AntiAge↑, *AST↓, *ALAT↓, *LDH↓, *lipid-P↓, Casp3↑, *memory↑, *Wound Healing↑, eff↑,
6651- Cen,    Study of the cytotoxicity of asiaticoside on rats and tumour cells
- vitro+vivo, BC, MCF7
Casp3↑, TNF-α↓, IL1β↓, Apoptosis↑, TumCCA↑, TumVol↓, radioP↑, Inflam↓,
6641- Cen,    Asiaticoside Increases Caspase-9 Activity in MCF-7 Cells and Inhibits TNF-α and IL-6 Expression in Nude Mouse Xenografts via the NF-κB Pathway
- in-vitro, BC, MCF7
Casp9↑, TNF-α↓, IL6↓, NF-kB↓, TumCG↓, Inflam↓, TumCP↓, EMT↓,
6647- Cen,    Protective effects of Centella asiatica extract on spatial memory and learning deficits in animal model of systemic inflammation induced by lipopolysaccharide
- in-vivo, AD, NA
*memory↑, *Wound Healing↑, *Inflam↓, *antiOx↑, *neuroP↑,
6648- Cen,    Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *Wound Healing↑, *memory↑, *Inflam↓, *hepatoP↑, *Imm↑, *cardioP↑, *AntiDiabetic↑, *AntiFungal↑, *antiOx↑, *Dose↝, *AChE↓, *BChE↓, *Tyro3↓, *lipid-P↓,
6650- Cen,    Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- Review, AD, NA
*BioAv↝, *BioAv↝, *MDA↓, *GSH↑, *SOD↑, *AChE↓, *memory↑, *Ki-67↑, *Catalase↑, *PI3K↑, *BDNF↑, *NGF↑, *ROS↓, *NRF2↑, *HO-1↑, *NQO1↑, *ATP↑, *OCR↑, *TNF-α↓, *PP2A↑, *GSK‐3β↓, *Bcl-2↑, *TrkB↑, *NOTCH1↑, *SOX2↑, *Nestin↑, *MDA↓, *MAOA↓, *MAOB↓, *GPx↑, *cognitive↑, *ROS↓, *neuroP↑, *glucose↓, *ALAT↓, *AST↓, *PFK↓, *Weight↓, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *cardioP↑, *GutMicro↑, *Sepsis↓, *BioAv↑,
6022- CGA,    Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *BP↓, *Dose↝, *ROS↓, *Fas↓, *HMG-CoA↓, *GutMicro↑,
6018- CGA,    Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems
- Review, Var, NA - Review, RCC, NA
*BioAv↓, *Inflam↓, *TNF-α↓, *NO↓, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *IL6↓, *IL1β↓, *TLR2↓, *MAPK↓, *NRF2↓, *HO-1↑, *NQO1↑, *cardioP↑, *neuroP↑, *SOD↑, *GSH↑, *ROS↓, *LDH↓, *MDA↓, *cognitive↑, *eff↑,
6016- CGA,    Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
antiOx↑, *Bacteria↓, AntiCan↑, *Inflam↓, *cardioP↑, *AntiDiabetic↑, *GutMicro↑, *eff↑, *eff↑, *ROS↓, *IronCh↑, *neuroP↑, *AChE↓, *BChE↓, *chemoPv↑, *BioAv⇅,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *Stroke↓, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6013- CGA,    Advances in Pharmacological Properties, Molecular Mechanisms, and Bioavailability Strategies of Chlorogenic Acid in Cardiovascular Diseases Therapy
- Review, CardioV, NA
*BioAv↝, *BioAv↝, *BP↓, *ROS↓, *NADPH↓, *AntiAg↑, *TXA2↓, *antiOx↑, *cardioP↑, *Inflam↓, *SOD↑, *Catalase↑, *Ferroptosis↓, *NF-kB↓, *JNK↓, *NRF2↑, *HO-1↑, *toxicity↓, *BioAv↓, *BioAv↑, *BioAv↑, Synergy↑,
6008- CGA,    Risk Assessment of Chlorogenic and Isochlorogenic Acids in Coffee By-Products
- Review, Nor, NA
*toxicity↓, *antiOx↑, *Bacteria↓, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *cardioP↑, *BP↓, *other↓, eff↓,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2/PTGS2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6011- CGA,    Chlorogenic Acid’s Role in Metabolic Health: Mechanisms and Therapeutic Potential
- Review, Nor, NA
*BioAv↓, *antiOx↑, *Inflam↓, *Bacteria↓, *hepatoP↑, *cardioP↑, *neuroP↑, *ROS↓, *NF-kB↓, *NRF2↑, *Obesity↓, *GutMicro↑, *AntiAg↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *OCLN↓, *VEGF↓, BioAv↝,
6014- CGA,    Exploring the Pharmacological Potential of Chlorogenic acid as an Anti-Cancer Agent and a Call for Advance Research
- Review, Var, NA
AntiCan↑, *hepatoP↑, *Bacteria↓, *antiOx↓, *AntiDiabetic↑, Apoptosis↓, TumCG↓, angioG↓, TumCI↓, TumCMig↓, ROS↝, Inflam↝,
6034- CGA,    Effect and mechanism of chlorogenic acid on cognitive dysfunction in mice by lipopolysaccharide-induced neuroinflammation
- in-vivo, AD, NA
*cognitive↑, *TNF-α↓, *antiOx↑, *Inflam↓, *neuroP↑, *BBB↑, *eff↑, *memory↑, *AKT1↓, *MMP9↓, *MAPK↓,
2398- CGA,    Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation
- in-vivo, Col, NA
PKM2↓, Glycolysis↓, NLRP3↓, Inflam↓, HK2↓, PDK1 / PDPK1↓, LDHA↓, GLUT1↓, ECAR↓,
7177- CHA,    Chaetocin inhibits the progression of neuroblastoma by targeting JAK2/STAT3 signaling pathway in SH-SY5Y cells
- in-vitro, neuroblastoma, SH-SY5Y
AntiCan↑, Inflam↓, tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, JAK2↓, STAT3↓,
6000- Chit,    Chitosan in Modern Pharmacotherapy: From Drug Encapsulation to Targeted Delivery Systems
- Review, Var, NA
DDS↑, toxicity↓, TJ↓, BioAv↑, *Bacteria↓, *Inflam↓, *antiOx↓, Wound Healing↑, other↝, eff↑, eff↑,
4481- Chit,    Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy
- Review, Var, NA
*BioAv↑, *toxicity↓, *antiOx↑, AntiCan↑, *Inflam↓, *ROS↓, *lipid-P↓, MDA↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, MDA↑, GSH↓, ChemoSen↑,
4487- Chit,  PreB,    Unravelling the Role of Chitin and Chitosan in Prebiotic Activity and Correlation With Cancer: A Narrative Review
- Review, Var, NA
*GutMicro↑, Apoptosis↑, BAX↑, Bcl-2↓, *Inflam↓, AntiTum↑,
6074- CHL,    Study Protocol of a Prospective Phase 2 Study of Chlorophyllin for the Management of Brain Radionecrosis in Patients With Diffuse Glioma (CHROME)
- Study, GBM, NA
*Inflam↓,
6079- CHL,    Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice
- in-vivo, Nor, NA
*eff↑, *GutMicro↑, *NF-kB↓, *MMPs↑, *TIMP1↓, *Inflam↓, *Dysb↓,
6093- CHOC,    The relevance of theobromine for the beneficial effects of cocoa consumption
- Review, Nor, NA - NA, Asthma, NA
*toxicity↓, *eff↑, *Half-Life↑, *antiAll↑, *Inflam↓, *HDL↑, *Obesity↓,
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
6083- CHOC,    Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer
- Review, Colon, NA
ROS↓, Inflam↓, TumCP↓, Apoptosis↑, *Dose↝, *BioAv↓, *BioAv↑, GSH↑, GSTs↑, PGE2↓, COX1↑, IL8↓, COX2/PTGS2↓, iNOS↓, NF-kB↓, chemoP↑,

Showing Research Papers: 251 to 300 of 1306
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1306

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 6,   antiOx↑, 37,   antiOx⇅, 2,   ARE↓, 1,   Catalase↓, 6,   Catalase↑, 6,   Fenton↑, 1,   frataxin↑, 1,   GCLC↑, 1,   GPx↑, 3,   GPx4↓, 5,   GSH↓, 28,   GSH↑, 7,   GSR↑, 1,   GSTs↑, 4,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 4,   HO-1↓, 4,   HO-1↑, 18,   HO-2↓, 1,   Iron↑, 4,   Iron↝, 1,   lipid-P?, 1,   lipid-P↓, 5,   lipid-P↑, 12,   MDA↓, 5,   MDA↑, 10,   MPO↓, 5,   NADH↓, 2,   NOX↓, 1,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 4,   NRF2↓, 16,   NRF2↑, 22,   Prx↓, 2,   Prx4↑, 1,   PrxII↓, 1,   PYCR1↓, 1,   ROS?, 1,   ROS↓, 36,   ROS↑, 218,   ROS⇅, 7,   ROS↝, 2,   i-ROS↓, 1,   i-ROS↑, 3,   mt-ROS↑, 5,   SOD?, 1,   SOD↓, 7,   SOD↑, 7,   SOD1↑, 1,   SOD2↓, 4,   SOD2↑, 1,   ac‑SOD2↓, 1,   Thiols↓, 2,   Trx↓, 2,   TrxR↓, 2,   TrxR1↓, 2,   xCT/SLC7A11↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 4,   IronCh∅, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 2,   CDC25↓, 7,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   EGF↓, 1,   ETC↓, 2,   HSP60/HSPD1↓, 1,   MFN2↑, 1,   mitResp↓, 1,   mitResp↑, 1,   MKK7↓, 1,   mtDam?, 1,   mtDam↓, 1,   mtDam↑, 23,   OCR↓, 2,   OXPHOS↓, 5,   OXPHOS↝, 1,   PDH↑, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 2,   SIRT3↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5-HETE↓, 1,   5LO↓, 6,   ACC↑, 1,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 2,   ACSL4↑, 1,   ALAT↓, 10,   AMPK↓, 1,   AMPK↑, 19,   AMPK↝, 1,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 20,   ATP↑, 1,   mt-ATP↓, 1,   BHB↑, 1,   Buty↑, 1,   CAIX/CA9↓, 3,   CRM↑, 2,   DHODH↓, 1,   ECAR↓, 1,   ECAR↝, 1,   ENO1↓, 1,   FAO↑, 1,   FASN↓, 8,   FFA/NEFA↓, 1,   G6PD↓, 1,   GLS↓, 1,   glucose↓, 2,   GlucoseCon↓, 9,   glut↓, 1,   GlutMet↓, 2,   Glycolysis↓, 32,   Glycolysis↝, 1,   GSK‐3β↓, 11,   GSK‐3β↑, 6,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 5,   HK2↓, 14,   HMG-CoA↓, 1,   HMGCS2↑, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 11,   lactateProd↑, 1,   LDHA↓, 6,   LDL↓, 1,   lipidLev↓, 1,   lipoGen↓, 1,   MCT4↓, 2,   NAD↓, 1,   NAD↑, 2,   NADPH↓, 3,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 6,   PDK3↑, 1,   PFK↓, 2,   PKM2↓, 13,   PLA2↓, 1,   Pyruv↓, 1,   SCD1↓, 2,   SCFAs↑, 1,   SIRT1↓, 8,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   TCA↓, 2,   Warburg↓, 10,  

Cell Death(tgid=5) ⓘ

AIF↑, 10,   APAF1↑, 9,   Apoptosis?, 4,   Apoptosis↓, 10,   Apoptosis↑, 233,   mt-Apoptosis↑, 1,   ASC↑, 1,   BAD↓, 1,   BAD↑, 7,   Bak↓, 1,   Bak↑, 8,   BAX↓, 4,   BAX↑, 96,   Bax:Bcl2↑, 19,   Bcl-2↓, 116,   Bcl-2↑, 3,   Bcl-xL↓, 24,   Bcl-xL↑, 1,   BID↑, 2,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↓, 1,   BIM↑, 3,   BNIP3↑, 1,   Casp↓, 1,   Casp↑, 39,   Casp↝, 1,   Casp1↓, 2,   Casp1↑, 2,   cl‑Casp1↓, 1,   Casp10↑, 1,   Casp12↑, 3,   Casp3↓, 7,   Casp3↑, 131,   cl‑Casp3↑, 19,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 18,   cl‑Casp7↑, 5,   Casp8↓, 2,   Casp8↑, 37,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↓, 2,   Casp9↑, 88,   cl‑Casp9↑, 9,   CellShr↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 3,   Cyt‑c↑, 82,   Diablo↑, 5,   DR5↓, 1,   DR5↑, 15,   DR5↝, 1,   Endon↑, 1,   FADD↑, 3,   Fap1↓, 1,   Fas?, 1,   Fas↓, 2,   Fas↑, 14,   FasL↓, 1,   FasL↑, 4,   Ferroptosis↑, 8,   GranB/GZMB↓, 1,   GranB/GZMB↝, 1,   GSDMD↑, 1,   IAP1↓, 9,   IAP2/BIRC3↓, 4,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 23,   iNOS↑, 1,   Mcl-1↓, 12,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 8,   MDM2↑, 2,   p‑MDM2↓, 1,   MOMP↓, 1,   MOMP↑, 5,   Necroptosis↑, 2,   necrosis↑, 3,   NOXA↑, 3,   p38↓, 4,   p38↑, 17,   p‑p38↓, 4,   p‑p38↑, 4,   Paraptosis↑, 1,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 4,   Pyro↑, 3,   survivin↓, 41,   TNFR 1↑, 1,   TRAIL↑, 3,   TRAIL⇅, 1,   TRAILR↑, 2,   TumCD↓, 2,   TumCD↑, 14,   XIAP↓, 26,   XIAP↑, 1,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 135,   Akt↑, 8,   p‑Akt↓, 31,   AKT1↓, 1,   Akt2↓, 1,   CaMKII ?, 1,   CIP2A↓, 1,   CK2↓, 6,   cMET↓, 1,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 2,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 33,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 47,   ERK↑, 5,   p‑ERK↓, 17,   p‑ERK↑, 1,   FGFR1↓, 1,   FOXD3↑, 1,   HCAR2↑, 4,   HER2/EBBR2↓, 11,   HGF/c-Met↓, 2,   Hippo↑, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGF-2R↑, 1,   IGFR↓, 1,   IKKα↓, 5,   IκB↓, 2,   JAK↓, 5,   JAK1↓, 3,   JAK1↑, 2,   JAK2↓, 18,   p‑JAK2↓, 1,   JAK3↓, 1,   JNK↓, 9,   JNK↑, 18,   p‑JNK↓, 3,   p‑JNK↑, 7,   LIMK1↓, 1,   MAPK↓, 36,   MAPK↑, 14,   MAPK↝, 1,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 4,   MKK4↓, 1,   MKP1↝, 1,   mTOR↓, 75,   mTOR↝, 2,   p‑mTOR↓, 9,   mTORC2↓, 2,   OR13G1?, 1,   p70S6↓, 1,   P70S6K↓, 3,   P90RSK↓, 1,   PDE3B↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 114,   PI3K↑, 2,   p‑PI3K↓, 5,   PIK3CA↓, 1,   PKA↓, 2,   p‑PKA↓, 1,   PKCδ↓, 10,   PRKCQ/PKCθ↓, 1,   PTEN↓, 5,   PTEN↑, 28,   Raf↓, 4,   c-Raf↓, 1,   RAS↓, 10,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 1,   p‑S6K↓, 1,   SHP1↓, 1,   SHP1↑, 2,   Sp1/3/4↓, 12,   STAT↓, 7,   STAT3↓, 78,   STAT3↑, 4,   p‑STAT3↓, 8,   STAT4↓, 1,   STAT6↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 9,   ATF4↝, 1,   CBP↓, 2,   cJun↓, 5,   cJun↑, 1,   p‑cJun↓, 1,   p‑cJun↑, 1,   cMyc↓, 35,   cMyc↑, 1,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMT3B↓, 3,   DNMTs↓, 7,   EZH2↓, 4,   FOXM1↓, 3,   FOXO1↓, 2,   FOXO1↑, 3,   FOXO3↓, 1,   FOXO3↑, 4,   FOXO3↝, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 2,   ac‑H4↓, 1,   ac‑H4↑, 1,   HATs↓, 5,   HATs↑, 3,   HDAC↓, 22,   HDAC1↓, 7,   HDAC2↓, 5,   HDAC3↓, 5,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 3,   HES1↓, 2,   Matr↓, 1,   miR-106b↓, 2,   miR-124-3p↓, 1,   miR-143↑, 1,   miR-148a↑, 1,   miR-155↓, 1,   miR-19b↓, 2,   miR-200b↑, 2,   miR-200c↑, 1,   miR-203↑, 1,   miR-21↓, 5,   miR-218↑, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 2,   miR-34a↓, 2,   miR-34a↑, 6,   miR-590-3p↑, 1,   Myc↓, 5,   n-MYC↓, 1,   OCT4↓, 8,   other?, 1,   other↓, 5,   other↑, 10,   other⇅, 1,   other↝, 16,   PCAF↓, 2,   PhotoS↑, 3,   sonoS↑, 1,   SOX2↓, 6,   SOX4↓, 2,   SOX4↑, 1,   SOX9?, 1,   SUMO↓, 1,   TCF-4↓, 1,   tumCV?, 2,   tumCV↓, 59,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 20,   cl‑CHOP/DDIT3↑, 1,   CUL1↝, 1,   CUL5↝, 1,   eIF2α↑, 6,   p‑eIF2α↓, 1,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 37,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 7,   GRP78/BiP↝, 1,   GRP94↑, 1,   HSP27↓, 5,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 5,   HSP72↓, 1,   HSP90↓, 8,   HSPs↓, 1,   HSPs↑, 1,   HTRA↓, 1,   IRE1↑, 2,   p‑IRE1↓, 1,   NQO2↑, 1,   PERK↑, 8,   p‑PERK↑, 1,   Proteasome↓, 1,   UPR↑, 7,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 7,   ATG7↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 13,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↓, 2,   LC3II↑, 14,   LC3s↑, 1,   MitoP↑, 1,   p62↓, 8,   p62↑, 3,   PARK2↑, 1,   SESN2↑, 2,   TumAuto↓, 1,   TumAuto↑, 47,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   ATM↑, 4,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DFF45↑, 1,   DNAdam↓, 6,   DNAdam↑, 55,   DNArepair↓, 3,   hTERT/TERT↓, 8,   MGMT↓, 1,   NHEJ↓, 1,   p16↑, 1,   P53↓, 3,   P53↑, 78,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 2,   p53 Wildtype↑, 1,   p73↑, 1,   PARP↓, 3,   PARP↑, 14,   cl‑PARP↓, 2,   cl‑PARP↑, 51,   PARP1↑, 3,   cl‑PARP1↑, 2,   PCNA↓, 32,   POLD1↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 11,   TOP1↓, 7,   TOP2↓, 5,   TOP2↑, 2,   TP53↓, 2,   TP53↑, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 14,   CDK1↑, 3,   CDK2↓, 31,   CDK2↑, 2,   CDK4↓, 36,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK6↓, 11,   CDK6↑, 1,   CDK7↓, 1,   CDK8↓, 2,   CHK1↓, 1,   CHK1↑, 1,   Chk2↑, 2,   Cyc↓, 2,   cycA1/CCNA1↓, 7,   CycB/CCNB1↓, 19,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 75,   cycD1/CCND1↑, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 19,   E2Fs↓, 4,   GADD45A↓, 1,   Ki-67↓, 29,   Ki-67↑, 1,   mitA↑, 2,   P21?, 1,   P21↓, 7,   P21↑, 46,   p‑P21↑, 1,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 19,   pRB↓, 3,   p‑pRB↓, 3,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA↓, 3,   TumCCA↑, 186,   WEE1↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 3,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 6,   CD24↓, 1,   CD34↓, 1,   cFos↓, 4,   CSCs?, 1,   CSCs↓, 32,   Diff↓, 2,   Diff↑, 6,   FGF↓, 1,   Gli↓, 2,   Gli1↓, 3,   HH↓, 4,   IGF-1?, 1,   IGF-1↓, 9,   IGF-2↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Jun↓, 1,   Ki-67↓, 29,   Ki-67↑, 1,   Let-7↑, 2,   mTORC1↓, 6,   p‑mTORC1↓, 1,   Nanog↓, 5,   Nestin↓, 3,   NOTCH↓, 14,   NOTCH↑, 1,   NOTCH1↓, 12,   NOTCH1↑, 3,   NOTCH3↓, 2,   p300↓, 3,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 2,   STAT1↓, 2,   TumCG↓, 83,   TumCG↑, 4,   TumCP↓, 163,   TumCP↑, 3,   Wnt↓, 37,   Wnt↑, 2,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 9,   AP-1↑, 1,   ASAP2↓, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 3,   Ca+2↑, 29,   Ca+2↝, 4,   i-Ca+2?, 1,   i-Ca+2↑, 1,   cal2↑, 1,   Cal9↑, 1,   CCN2/CTGF↓, 3,   Cdc42↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 1,   COL1↓, 2,   COL3A1↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 32,   EMT↓, 65,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 2,   FAK↓, 17,   FAK↑, 1,   p‑FAK↓, 5,   fascin↓, 1,   Fibronectin↓, 1,   GIT1↓, 1,   GLI2↓, 1,   ITGB1↓, 3,   ITGB3↓, 1,   ITGB4↓, 1,   KRAS↓, 1,   LAMs↓, 2,   LEF1↓, 2,   LIMK2↓, 1,   LRP1↑, 1,   MALAT1↓, 2,   MET↓, 1,   MET↑, 1,   p‑MET↓, 1,   MMP1↓, 6,   MMP13↓, 3,   MMP2↓, 74,   MMP2↑, 1,   MMP3↓, 4,   MMP7↓, 7,   MMP9↓, 93,   MMP9↑, 4,   MMPs↓, 36,   MUC4↓, 2,   N-cadherin↓, 19,   pax↓, 1,   PDGF↓, 6,   PGF↓, 1,   Rac1↓, 2,   RECK↑, 1,   Rho↓, 5,   ROCK1↓, 3,   Slug↓, 8,   Smad1↓, 1,   SMAD2↓, 1,   SMAD3↓, 2,   Snail↓, 13,   TET1↑, 3,   TGF-β↓, 18,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 2,   TIMP1↑, 8,   TIMP2↓, 1,   TIMP2↑, 7,   TIMP3↑, 1,   pol-TregCell↓, 1,   TRIB3↑, 3,   TSP-1↑, 2,   TumCA↓, 3,   TumCI↓, 98,   TumCMig↓, 90,   TumCMig↑, 1,   TumMeta↓, 86,   TumMeta↑, 7,   TumPF↓, 1,   Twist↓, 14,   TXNIP↑, 1,   uPA↓, 19,   uPAR↓, 1,   Vim?, 1,   Vim↓, 16,   Zeb1↓, 9,   Zeb1↑, 1,   ZEB2↓, 1,   α-SMA↓, 3,   α-SMA↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 50,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 125,   angioG↑, 2,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 5,   Endoglin↑, 1,   eNOS↑, 1,   HIF-1↓, 7,   Hif1a↓, 44,   HIF2a↓, 1,   Hypoxia↓, 1,   LOX1↓, 3,   NO↓, 7,   NO↑, 3,   PGI2↓, 1,   PHDs↓, 1,   VCAM-1↓, 2,   VEGF↓, 100,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 16,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 7,   BBB∅, 1,   CellMemb↑, 1,   CLDN2↓, 1,   CX43/GJA1↓, 1,   EPR↑, 3,   GLUT1↓, 11,   GLUT4↓, 1,   IBI↑, 1,   MMP↓, 111,   MMP↑, 2,   MPT↑, 6,   NHE1↓, 2,   OATPs↓, 1,   TJ↓, 1,   TRPM7↓, 3,   TRPV1↓, 1,   TRPV1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 3,   CCR7↓, 1,   CD25+↓, 1,   CD25+↑, 1,   CD4+↓, 2,   CD4+↑, 2,   CD44↓, 8,   CD47↓, 1,   CD59↑, 1,   CD8+↑, 4,   p‑cDC2↓, 1,   COX1↓, 7,   COX1↑, 1,   COX2/PTGS2↓, 113,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCR4↓, 14,   DR4↑, 4,   Eos↑, 1,   FOXP3↑, 2,   FoxP3+↓, 1,   HCAR2↑, 4,   HLA-I/II↑, 1,   HMGB1↓, 5,   ICAM-1↓, 10,   IFN-γ↓, 8,   IFN-γ↑, 3,   IL1↓, 4,   IL1↑, 1,   IL10↓, 9,   IL10↑, 2,   IL12↑, 2,   IL17↓, 3,   IL17↑, 1,   IL18↓, 1,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 38,   IL1β↑, 3,   IL2↓, 5,   IL2↑, 3,   IL22↓, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 1,   IL5↓, 1,   IL6↓, 61,   IL6↑, 2,   IL8↓, 11,   IL8↑, 1,   Imm↑, 29,   Imm↝, 6,   INF-γ↓, 1,   INF-γ↝, 1,   Inflam↓, 214,   Inflam↑, 3,   Inflam↝, 2,   LPS↓, 1,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 9,   MCT1↓, 2,   MDSCs↓, 1,   MIP-1β↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 1,   MyD88↑, 1,   Neut↑, 2,   NF-kB?, 1,   NF-kB↓, 170,   NF-kB↑, 6,   p‑NF-kB↓, 1,   p‑NF-kB↑, 2,   NK cell↑, 7,   NLRP3↓, 8,   NLRP3↑, 3,   NOD1↓, 1,   p65↓, 4,   p‑p65↓, 3,   PD-1↓, 3,   PD-L1↓, 9,   PGE2↓, 31,   PGE2↑, 1,   PSA↓, 12,   RAGE↓, 2,   RANTES↓, 1,   SOCS-3↓, 1,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 1,   TLR4↓, 10,   TLR4↑, 1,   TNF-α↓, 56,   TNF-α↑, 5,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   GGT/CD224↓, 1,   pH↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 2,   ADAM10?, 1,   ADAM10↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   PSEN2/PS-2↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ADRB2↓, 1,   AR↓, 10,   AR-V7?, 1,   CYP19?, 1,   ER(estro)↓, 1,   EstroRS/ERS↑, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 4,   PPARγ↑, 8,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 55,   BioAv↑, 59,   BioAv⇅, 1,   BioAv↝, 15,   BioEnh↑, 2,   CBR1↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 181,   ChemoSen⇅, 1,   ChemoSen↝, 1,   CompStab?, 1,   CompStab↑, 3,   CompStab↝, 3,   CYP1A1↓, 5,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP3A2↓, 1,   CYP3A4↓, 1,   DDS↑, 2,   Dose?, 5,   Dose↓, 3,   Dose↑, 10,   Dose⇅, 1,   Dose↝, 64,   Dose∅, 9,   DrugR↓, 1,   eff↓, 15,   eff↑, 87,   eff⇅, 1,   eff↝, 18,   eff∅, 4,   GSTM1↑, 1,   Half-Life↓, 15,   Half-Life↑, 2,   Half-Life↝, 16,   MDR1↓, 5,   MRP1/ABCC1↓, 3,   MRP1/ABCC1↝, 1,   NAT↓, 1,   P-gp/ABCB1↓, 16,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   P450↓, 2,   P450↝, 1,   RadioS↑, 53,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 90,   selectivity∅, 1,   Synergy↓, 1,   Synergy↑, 117,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 3,   ALAT↓, 10,   ALB↑, 1,   ALP↓, 2,   AR↓, 10,   ascitic↓, 1,   AST?, 1,   AST↓, 7,   BloodF⇅, 1,   BP↓, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BUN↓, 1,   CA19-9↓, 1,   CEA↓, 2,   creat↓, 2,   CRP↓, 9,   DBIL↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 33,   EGFR↑, 1,   p‑EGFR↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 4,   FOXM1↓, 3,   HER2/EBBR2↓, 11,   hTERT/TERT↓, 8,   IBIL↓, 1,   IL6↓, 61,   IL6↑, 2,   KRAS↓, 1,   LDH↓, 7,   LDH↑, 2,   LDH↝, 1,   Maspin↑, 1,   Myc↓, 5,   NLR↓, 1,   NOS2↓, 1,   NOS2↑, 1,   PC↑, 1,   PD-L1↓, 9,   Polyps↓, 1,   PSA↓, 12,   RAGE↓, 2,   RBC↑, 1,   TBIL↓, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 1,   TRIB3↑, 3,   Tumccf↓, 2,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiArt↑, 1,   AntiCan?, 1,   AntiCan↓, 5,   AntiCan↑, 121,   AntiCan⇅, 1,   AntiCan∅, 1,   antiD↑, 1,   AntiDiabetic↑, 3,   antiNeop↑, 5,   AntiTum↓, 1,   AntiTum↑, 53,   AntiTum∅, 1,   Appetite↑, 1,   cachexia↓, 1,   cardioP↑, 19,   CardioT↑, 2,   chemoP↑, 65,   chemoPv↑, 29,   ChemoSideEff↓, 4,   cognitive?, 1,   cognitive↑, 6,   DCR↑, 1,   fatigue↓, 2,   fatigue∅, 1,   hepatoP↓, 1,   hepatoP↑, 19,   hepatoP∅, 1,   memory↑, 4,   Mood↑, 1,   Mucositis↓, 1,   neuroP↑, 21,   NP/CIPN↓, 3,   Obesity↓, 2,   OS↓, 1,   OS↑, 19,   OS↝, 1,   OS∅, 2,   Pain↓, 6,   PFS↑, 1,   PFS∅, 1,   QoL↑, 8,   QoL∅, 1,   radioP↑, 23,   Remission↑, 1,   RenoP↑, 15,   Risk↓, 41,   Risk↑, 2,   Sleep↑, 2,   toxicity↓, 20,   toxicity↑, 5,   toxicity↝, 13,   toxicity∅, 3,   TumNum↓, 1,   TumVol↓, 16,   TumW↓, 7,   Weight↓, 1,   Weight↑, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiViral↑, 2,   Bacteria↓, 5,   GutMicro↑, 18,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 1,   Ingr↝, 9,  
Total Targets: 1058

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,   NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 4,   antiOx?, 2,   antiOx↓, 37,   antiOx↑, 535,   ARE↑, 7,   ARE↝, 1,   Bil↑, 2,   Catalase↓, 4,   Catalase↑, 152,   Copper↓, 1,   DPPH↓, 2,   DUOX1↓, 1,   Fenton↓, 5,   GCLC↑, 4,   GCLC↝, 1,   GCLM↑, 3,   GCLM↝, 1,   GPx↓, 2,   GPx↑, 112,   GPx1↑, 4,   GPx3↑, 1,   GPx4↓, 1,   GPx4↑, 6,   GSH↓, 4,   GSH↑, 162,   GSR↓, 2,   GSR↑, 24,   GSS↑, 1,   GSSG↓, 2,   GSTs↓, 4,   GSTs↑, 27,   H2O2↓, 8,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 13,   HDL∅, 1,   HNE↓, 3,   HO-1?, 1,   HO-1↓, 4,   HO-1↑, 139,   HO-1⇅, 1,   HO-1↝, 1,   HO-2↓, 1,   hyperG↓, 3,   hyperG↝, 1,   Iron↓, 4,   Iron↑, 1,   Iron↝, 1,   Iron∅, 1,   Keap1↓, 8,   Keap1↑, 1,   Keap1↝, 2,   lipid-P?, 1,   lipid-P↓, 143,   lipid-P↑, 3,   mt-lipid-P↓, 1,   MDA↓, 139,   MDA↑, 4,   MPO↓, 28,   MPO↑, 1,   NADH↓, 1,   NFE2L2↓, 1,   NOX↓, 3,   NOX1↓, 1,   NOX2↓, 2,   NOX4↓, 9,   NQO1↑, 35,   NQO1↝, 2,   Nrf1↑, 2,   NRF2?, 1,   NRF2↓, 7,   NRF2↑, 236,   NRF2↝, 1,   NRF2∅, 1,   Prx↓, 1,   Prx↑, 2,   RNS↓, 8,   ROS?, 5,   ROS↓, 567,   ROS↑, 11,   ROS⇅, 4,   ROS↝, 1,   ROS∅, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   SAM-e↑, 1,   selenoP↑, 10,   SOD↓, 6,   SOD↑, 210,   mt-SOD↑, 1,   SOD1↑, 9,   SOD2↓, 1,   SOD2↑, 9,   TAC↑, 24,   TBARS↓, 9,   Thiols↑, 2,   TOS↓, 2,   Trx↓, 1,   Trx↑, 6,   Trx1↑, 2,   TrxR↑, 1,   TrxR1↑, 1,   UCPs↑, 2,   uricA↓, 5,   VitC↑, 9,   VitE↓, 1,   VitE↑, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 22,   IronCh↝, 1,   Mets↝, 1,   NCOA4↝, 1,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 2,   compII↑, 2,   compIII↑, 2,   compIV↑, 3,   DRP1/DNM1L↓, 1,   EGF↓, 1,   EGF↑, 1,   ETC↑, 3,   HSP60/HSPD1↓, 1,   Insulin↓, 4,   Insulin↑, 3,   MFN2↑, 2,   mitResp↑, 3,   mtDam↓, 10,   mtDam↑, 1,   OCR↓, 1,   OCR↑, 4,   OXPHOS↑, 1,   PDH↑, 1,   PGC-1α↓, 3,   PGC-1α↑, 10,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 2,   SIRT3↑, 8,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   12LOX↓, 2,   12LOX↑, 1,   5-HETE↓, 1,   5LO↓, 19,   5LO↝, 1,   ACC↓, 1,   ACC↑, 2,   Acetyl-CoA↓, 1,   Acetyl-CoA↑, 3,   ACSL4↓, 2,   adiP↓, 1,   adiP↑, 4,   ALAT?, 1,   ALAT↓, 55,   ALAT∅, 1,   AMPK↓, 2,   AMPK↑, 47,   p‑AMPK↑, 3,   ATP↓, 1,   ATP↑, 28,   ATP↝, 1,   BHB↑, 1,   Buty↑, 1,   cAMP↑, 6,   CPT1A↑, 1,   CRM↑, 3,   cytoP450↓, 1,   ECAR↓, 1,   Eic↓, 1,   FABP4↓, 1,   FAO↓, 1,   FAO↑, 3,   FASN↓, 3,   FFA/NEFA↓, 1,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 18,   glucose↑, 2,   glucose↝, 4,   GlucoseCon↓, 1,   GlucoseCon↑, 11,   Glycolysis↓, 3,   Glycolysis↑, 1,   GSK‐3β↓, 25,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 4,   H2S↑, 2,   HK2↓, 2,   HMG-CoA↓, 3,   KeyT↝, 1,   lactateProd↓, 1,   LDHA↓, 2,   LDL↓, 43,   lipidLev↓, 7,   lipoGen↓, 1,   LTB4↓, 1,   LTC4↓, 1,   NAD↓, 1,   NAD↑, 3,   NAD↝, 1,   NADH:NAD↑, 1,   NADPH↓, 15,   NADPH↑, 10,   PDKs↓, 1,   PFK↓, 1,   PFK1↓, 1,   PFKP↓, 1,   PGC1A↑, 1,   PGM1?, 1,   PKM2↓, 8,   PLA2↓, 2,   PONs↓, 1,   PONs↑, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 48,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,   SREBP1/SREBF1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 75,   Apoptosis↑, 2,   ASK1↓, 1,   BAD↓, 1,   BAX↓, 27,   BAX↑, 1,   Bax:Bcl2↓, 5,   Bcl-2↓, 5,   Bcl-2↑, 22,   Bcl-2↝, 1,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 4,   Casp1↓, 3,   Casp12↓, 2,   Casp3↓, 49,   Casp3↑, 3,   Casp3∅, 1,   cl‑Casp3↓, 6,   proCasp3↓, 1,   Casp6↓, 1,   Casp8↓, 2,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 19,   Casp9↑, 2,   Cyt‑c↓, 8,   Cyt‑c↑, 1,   Cyt‑c∅, 2,   Fas↓, 2,   Ferroptosis↓, 14,   GranB/GZMB↓, 1,   GRP58↓, 1,   GSDMD?, 1,   GSDMD↓, 1,   iNOS↓, 88,   iNOS↑, 3,   necrosis↓, 3,   p38↓, 9,   p38↑, 1,   p‑p38↓, 7,   Pyro↓, 1,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   Akt↑, 36,   Akt↝, 1,   p‑Akt↓, 6,   p‑Akt↑, 4,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 2,   CREB↓, 1,   CREB↑, 9,   p‑CREB↑, 3,   DYRK1A↓, 2,   EGFR↓, 1,   ERK↓, 14,   ERK↑, 14,   p‑ERK↓, 4,   p‑ERK↑, 3,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   HGF/c-Met↑, 2,   IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB?, 1,   JAK↓, 3,   JAK2↓, 3,   JAK2↑, 3,   JNK↓, 20,   JNK↑, 1,   p‑JNK↓, 7,   MAPK?, 1,   MAPK↓, 46,   MAPK↑, 5,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   Mst1↓, 1,   mTOR↓, 14,   mTOR↑, 8,   mTOR↝, 1,   p‑mTOR↓, 5,   P70S6K↓, 1,   PDGFR-BB↓, 2,   PDGFR-BB↑, 1,   PDGFRB↓, 1,   PI3K↓, 12,   PI3K↑, 25,   PI3K↝, 1,   PKA↑, 3,   PKCδ↓, 4,   PKCδ↑, 6,   PP2A↑, 4,   PTEN↓, 5,   PTEN↑, 1,   PTP1B↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT↓, 4,   STAT3?, 1,   STAT3↓, 11,   STAT3↑, 5,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT4↓, 1,   STAT5↓, 1,   STEP↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 14,   ATF2↑, 1,   ATF4↓, 4,   cJun↓, 2,   p‑cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 2,   FOXO↑, 3,   FOXO3↑, 6,   HATs↓, 2,   HDAC?, 1,   HDAC↓, 4,   HDAC↑, 2,   HDAC2↓, 2,   HOTAIR↑, 1,   KLF4↑, 1,   miR-155↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other?, 3,   other↓, 19,   other↑, 32,   other↝, 51,   other∅, 1,   SOX2↑, 1,   SOX9↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 13,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 28,   ER Stress↑, 1,   GRP78/BiP↓, 11,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSF1↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 12,   HSP70/HSPA5↝, 1,   HSP90↓, 1,   HSP90↑, 2,   HSPs↓, 1,   HSPs↑, 2,   HSPs↝, 1,   IRE1↓, 3,   NQO2↑, 1,   PERK↓, 1,   p‑PERK↓, 1,   UPR↓, 1,   UPR↑, 2,   XBP-1↓, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 8,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 3,   LC3II↓, 2,   LC3II↑, 4,   MitoP↓, 1,   MitoP↑, 3,   p62↓, 3,   p62↑, 4,   PARK2↑, 4,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   ATR↑, 1,   DNAdam↓, 30,   p16↓, 2,   P53↓, 6,   PARP↓, 2,   PARP1↓, 2,   cl‑PARP1↓, 1,   PCNA↓, 4,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   TP53↑, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK5↓, 2,   cellSen↓, 1,   cellSen↝, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   Ki-67↑, 2,   P21↓, 3,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CEBPA↓, 1,   cFos↑, 1,   CHIP↑, 1,   Choline↑, 2,   Diff↑, 4,   Diff↝, 2,   EP2↓, 1,   FGF↑, 3,   GH↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 4,   IGFBP1↑, 1,   Jun↓, 1,   Ki-67↓, 1,   Ki-67↑, 2,   MSCs↑, 1,   mTORC1↓, 1,   Nestin↑, 1,   neuroG↑, 12,   NOTCH1↑, 1,   STAT1↓, 1,   TumCG↑, 1,   TumCP↓, 5,   tyrosinase↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 5,   AntiAg↑, 43,   AntiAg∅, 1,   AP-1↓, 11,   AP-1↑, 1,   ARG1/2↑, 1,   Ca+2?, 2,   Ca+2↓, 18,   Ca+2↑, 7,   Ca+2↝, 4,   cal2↓, 1,   Cartilage↑, 9,   COL1↓, 2,   COL1↑, 2,   COL2A1↑, 2,   COL3A1↓, 1,   E-cadherin↑, 2,   EMT↓, 2,   EMT↑, 1,   F-actin↑, 1,   FAK↑, 1,   Fibronectin↓, 1,   Fibronectin↑, 1,   Fibrosis↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   LRP1↑, 3,   MLC2/MYL9↝, 1,   MMP-10↓, 2,   MMP-10↝, 1,   MMP1↓, 1,   MMP13↓, 6,   MMP2↓, 7,   MMP2↑, 2,   MMP3↓, 3,   MMP3↑, 1,   MMP9↓, 21,   MMP9↑, 2,   MMPs↓, 3,   MMPs↑, 3,   MUC1↑, 4,   N-cadherin↑, 1,   Na+↑, 1,   NFAT↓, 1,   PDGF↓, 1,   PDGF↑, 1,   p‑Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 4,   serineP↓, 1,   SLIT2↑, 1,   SMAD3↓, 1,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 10,   TGF-β↑, 10,   TGF-β1↓, 4,   TGF-β1↑, 3,   TIMP1↓, 5,   TIMP1↑, 3,   TIMP2↑, 2,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   Twist↑, 1,   TXNIP↓, 6,   Tyro3↓, 1,   uPA↑, 1,   Vim↓, 2,   Vim↑, 1,   α-SMA↓, 6,   α-SMA↑, 1,   α-SMA↝, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   angioG↑, 8,   angioG↝, 1,   CD31/PECAM-1↓, 1,   CD31/PECAM-1↑, 1,   E-sel↓, 5,   ECM/TCF↑, 1,   eNOS↓, 1,   eNOS↑, 4,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 8,   Hif1a↑, 3,   Hif1a↝, 1,   Hif1a∅, 1,   HIF2a↑, 1,   LOX1↓, 1,   NO?, 1,   NO↓, 67,   NO↑, 7,   P-sel↓, 1,   TXA2↓, 3,   VCAM-1↓, 19,   VEGF↓, 13,   VEGF↑, 11,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 2,   BBB↓, 8,   BBB↑, 80,   BBB↝, 6,   BBB∅, 3,   CLDN1↓, 2,   CLDN1↑, 3,   CLDN3↑, 1,   CLDN4↑, 1,   EPR↑, 2,   GastroP↑, 14,   GLUT1↑, 2,   GLUT2↑, 1,   GLUT3↑, 2,   GLUT4↑, 6,   H+/K+-ATPase↓, 1,   IBI↑, 12,   ketosis↑, 1,   memfluid↑, 2,   MMP↓, 2,   MMP↑, 30,   MMP∅, 2,   MUC19↓, 1,   MUC2↓, 1,   MUC2↑, 1,   MUC5AC↓, 2,   Na+↑, 1,   OATPs↓, 1,   OCLN↓, 2,   OCLN↑, 6,   OCLN↝, 1,   TJ↓, 1,   TJ↑, 6,   TRPA1↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 5,   TRPV3↑, 2,   VGCC↓, 1,   VGSC↓, 1,   ZO-1↓, 2,   ZO-1↑, 9,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   BALF-Infl↓, 1,   BALF-Lym↓, 1,   CB2 / CNR2↑, 5,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 5,   CD40↓, 1,   CD8+↑, 1,   cGAS–STING↓, 2,   COX1↓, 14,   COX1↑, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 144,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCL1↓, 1,   CXCL15↓, 1,   CXCR2↓, 1,   CXCR3↓, 1,   CXCR4↓, 1,   Eos↓, 5,   FOXP3↑, 1,   GM-CSF↓, 1,   HCAR2↑, 1,   HMGB1↓, 9,   ICAM-1↓, 17,   IFN-γ↓, 21,   IFN-γ↑, 4,   IFN-γ∅, 1,   IgE↓, 4,   IgG1↓, 1,   IL1?, 1,   IL1↓, 11,   IL1↑, 1,   IL10?, 1,   IL10↓, 16,   IL10↑, 32,   IL12↓, 8,   IL13↓, 6,   IL17↓, 16,   IL17↑, 1,   IL18↓, 4,   IL1RL1/ST2↓, 1,   IL1α↓, 1,   IL1β↓, 164,   IL1β↑, 1,   IL2↓, 15,   IL2↑, 1,   IL22↓, 1,   IL23↓, 3,   IL33↓, 3,   IL4↓, 20,   IL4↑, 7,   IL5↓, 8,   IL5↑, 1,   IL6?, 3,   IL6↓, 197,   IL6↑, 4,   IL8?, 1,   IL8↓, 35,   IL8↑, 1,   ILC2↓, 1,   Imm↓, 1,   Imm↑, 48,   Imm↝, 4,   INF-γ↓, 3,   Inflam?, 6,   Inflam↓, 1076,   Inflam↑, 16,   Inflam∅, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 4,   LPS↓, 2,   LTA/TNF-β↓, 1,   LTA/TNF-β↑, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 21,   MCP1/CCL2↑, 2,   MCP1/CCL2↝, 1,   MIP‑1α/CCL3↓, 2,   MIP2↓, 3,   MyD88↓, 8,   NeuroI↓, 4,   Neut↓, 1,   Neut↑, 2,   NF-kB↓, 249,   NF-kB↑, 2,   p‑NF-kB↓, 4,   NK cell↑, 6,   NLRP3↓, 67,   NLRP3↑, 4,   p65↓, 6,   PAF↓, 2,   PAF↑, 1,   PGE1↓, 1,   PGE2↓, 52,   PGE2↑, 2,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 5,   RANTES↓, 4,   Th1 response↓, 1,   Th17↓, 1,   Th2↓, 2,   TLR1↓, 3,   TLR2↓, 8,   TLR3↓, 1,   TLR4↓, 36,   TLR4↑, 1,   TLR4∅, 1,   TNF-α?, 1,   TNF-α↓, 269,   TNF-α↑, 4,   TRAF1↓, 1,   Treg lymp↑, 1,   Treg lymp↝, 1,   TRIF↓, 3,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,   GGT/CD224↓, 1,   TREM2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 2,   5HT↓, 1,   5HT↑, 16,   Ach↑, 25,   AChE↓, 98,   AChE↑, 1,   AChE∅, 2,   ADAM10↑, 6,   ADAM10↝, 1,   BChE↓, 24,   BChE∅, 1,   BDNF↓, 3,   BDNF↑, 71,   BDNF∅, 2,   proBDNF↑, 1,   BrainVol↑, 2,   ChAT↑, 13,   ChE↓, 1,   GABA↓, 3,   GABA↑, 9,   GABA↝, 1,   MAOA↓, 13,   MAOB↓, 4,   monoA↑, 1,   NGF↑, 9,   PSD95↑, 6,   SNAP25↑, 2,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 8,  

Protein Aggregation(tgid=19) ⓘ

AEP↓, 1,   AGEs↓, 12,   APOE4↓, 1,   APP↓, 15,   APP∅, 1,   cl‑APP↑, 1,   Aβ↓, 164,   Aβ↑, 2,   Aβ∅, 2,   Aβ42↓, 10,   BACE/β-secretase↓, 37,   BACE/β-secretase↑, 1,   IDE↑, 1,   NEP↑, 1,   PSEN1/PS1↑, 1,   tau↓, 37,   p‑tau↓, 49,   XO↓, 2,   XO↝, 1,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AhR↑, 2,   AR↓, 1,   BNP↓, 1,   cortisol↓, 1,   cortisol↑, 1,   CYP19↓, 1,   DHT↑, 1,   ER(estro)↓, 1,   ER(estro)↑, 2,   ERβ/ESR2↑, 1,   Estro↓, 1,   GLP-1R↑, 1,   GR↑, 1,   NR1H4↑, 1,   PPARα↑, 10,   PPARα↝, 1,   PPARγ↓, 5,   PPARγ↑, 24,   RAAS↓, 1,   SHBG↓, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 84,   BioAv↑, 127,   BioAv⇅, 3,   BioAv↝, 74,   BioEnh↑, 12,   ChemoSen↑, 3,   CompStab↓, 2,   CompStab↑, 7,   CompStab↝, 3,   CYP2C19↓, 1,   CYP2C9↓, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 10,   Dose↓, 3,   Dose↑, 9,   Dose↝, 148,   eff?, 1,   eff↓, 9,   eff↑, 88,   eff↝, 11,   GSTA1↑, 7,   Half-Life?, 1,   Half-Life↓, 18,   Half-Life↑, 9,   Half-Life↝, 31,   P-gp/ABCB1↓, 3,   P450↓, 3,   P450↑, 1,   RadioS↑, 1,   selectivity↑, 5,   Synergy↑, 50,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 55,   ALAT∅, 1,   ALB↑, 2,   ALB↝, 1,   ALP↓, 10,   anemia↓, 1,   AR↓, 1,   AST↓, 56,   AST∅, 1,   BG↓, 4,   Bil↑, 2,   BloodF↑, 13,   BMD↑, 8,   BP↓, 30,   BP↝, 1,   BP∅, 1,   BUN?, 1,   BUN↓, 6,   Calcium↑, 1,   Calcium↝, 2,   CEA↓, 1,   CK/CK-MB↓, 1,   colonLen↑, 2,   creat↓, 16,   CRP↓, 22,   EGFR↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   HbA1c↓, 1,   Hcy/homoC↓, 3,   Hcy/homoC↝, 1,   HemoG↑, 2,   HER2/EBBR2↓, 1,   HOMA↓, 1,   hs-CRP↓, 5,   IL6?, 3,   IL6↓, 197,   IL6↑, 4,   IRes↓, 1,   IRes↑, 1,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 19,   LDH↑, 1,   Mag↑, 1,   NLR↓, 1,   NOS2↓, 5,   PSA↓, 1,   PSA∅, 1,   PV↓, 3,   RAGE↓, 5,   RBC↑, 1,   SpO2↑, 1,   TC↓, 5,   TG/TAG↓, 6,   TMAO↓, 1,   TMAO↑, 1,   TP53↑, 1,   UFR?, 1,   UFR↑, 2,   UR↓, 1,   Urea↓, 5,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 2,   AirwayM↓, 4,   Analgesic↑, 6,   AntiAge↑, 35,   antiAll?, 1,   antiAll↑, 47,   AntiArt↑, 18,   AntiCan?, 1,   AntiCan↓, 2,   AntiCan↑, 82,   antiCG↑, 2,   antiD↑, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 93,   antiM↑, 1,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 3,   antiPy↑, 1,   AntiTum↓, 2,   AntiTum↑, 26,   ANXi↓, 1,   BOLD↑, 1,   Bone Healing↑, 1,   cachexia↓, 1,   cardioP?, 1,   cardioP↓, 3,   cardioP↑, 180,   cardioP⇅, 1,   cardioP∅, 1,   chemoP↑, 28,   chemoPv↑, 21,   ChemoSideEff↓, 1,   cognitive↓, 4,   cognitive↑, 221,   cognitive↝, 1,   cognitive∅, 1,   cough?, 1,   diuretic↑, 6,   fatigue↓, 3,   Hear↑, 1,   hepatoP↓, 5,   hepatoP↑, 164,   IPSS↝, 1,   Learn?, 1,   Learn↑, 16,   memory?, 1,   memory↑, 186,   memory∅, 1,   Mood↑, 13,   motorD↓, 1,   motorD↑, 24,   Mucositis↓, 2,   neuroP?, 3,   neuroP↓, 3,   neuroP↑, 405,   neuroP↝, 1,   NP/CIPN↓, 3,   Obesity↓, 39,   OS↑, 15,   Pain↓, 27,   PDE4↓, 1,   QoL↓, 1,   QoL↑, 9,   radioP↑, 16,   RenoP↑, 50,   Risk↓, 19,   Risk↑, 1,   Sleep↑, 8,   SoreThr?, 1,   Strength↓, 1,   Strength↑, 8,   Stress↓, 3,   Stroke↓, 31,   Tinn↓, 1,   toxicity?, 1,   toxicity↓, 93,   toxicity↑, 12,   toxicity⇅, 1,   toxicity↝, 22,   toxicity∅, 11,   Weight↓, 6,   Weight↑, 2,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 21,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 54,   AntiFungal↓, 2,   AntiFungal↑, 24,   AntiP↓, 1,   AntiP↑, 7,   AntiViral↑, 38,   Bacteria↓, 89,   Bacteria↑, 1,   Diar↓, 6,   Dysb↓, 1,   GutMicro↑, 93,   GutMicro↝, 2,   Inf↓, 3,   Sepsis↓, 20,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   CA↑, 1,   Catechins↑, 1,   FA↑, 1,   Fibre↑, 1,   Flav↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↑, 6,   Ingr↝, 35,   LT↑, 1,   Myr↑, 1,   Phen↑, 1,   Poly↑, 1,   QC↑, 2,  
Total Targets: 1030

Scientific Paper Hit Count for: Inflam, inflammation
43 Hydrogen Gas
41 Curcumin
34 Magnetic Fields
33 Thymoquinone
32 Quercetin
30 Silymarin (Milk Thistle) silibinin
24 Resveratrol
20 Lycopene
18 Alpha-Lipoic-Acid
18 Berberine
18 Selenium NanoParticles
18 Fisetin
18 Rosmarinic acid
16 Ashwagandha(Withaferin A)
16 Ferulic acid
16 Sulforaphane (mainly Broccoli)
15 Capsaicin
15 Carvacrol
15 Honokiol
15 Kaempferol
15 Luteolin
15 Urolithin
14 Propolis -bee glue
14 Emodin
14 Eugenol
14 Licochalcone A
13 Silver-NanoParticles
13 Apigenin (mainly Parsley)
13 Beta-Caryophyllene
12 Radiotherapy/Radiation
12 Baicalein
12 Chlorogenic acid
12 Chrysin
11 Cinnamon
11 Isoliquiritigenin
10 Crocetin
10 Chemotherapy
10 Dandelion Root
10 EGCG (Epigallocatechin Gallate)
10 Matrine
10 Pterostilbene
9 Selenite (Sodium)
9 Isovitexin
9 Boron
9 Ginger/6-Shogaol/Gingerol
9 Magnolol
9 Morin
8 Astaxanthin
8 Boswellia (frankincense)
8 α-Bisabolol / Chamomile oil
8 Rutin
8 Diclofenac
8 Fucoidan
8 Licorice
8 Piperlongumine
8 Vitamin C (Ascorbic Acid)
8 Shikonin
7 Allicin (mainly Garlic)
7 Betulinic acid
7 Vitamin B3,Niacin
7 Cisplatin
7 Butyrate
7 Centella asiatica / Gotu kola → asiaticoside
7 D-limonene
7 Gallic acid
7 Hyperoside
7 Moringa oleifera
7 Mushroom Lion’s Mane, Hericium erinaceus
7 Piperine
6 1,8-Cineole
6 Artemisinin
6 Aspirin
6 Caffeic acid
6 Thymol-Thymus vulgaris
6 Hydroxycinnamic-acid
6 Flaxseed/Linseed
6 Garcinol
6 HydroxyTyrosol
6 isoorientin
6 Vitexin
6 L-Theanine
6 Methylsulfonylmethane
5 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
5 Melatonin
5 Folic Acid, Vit B9
5 Phenethyl isothiocyanate
5 doxorubicin
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Celastrol
5 chitosan
5 Chocolate
5 Coenzyme Q10
5 Ellagic acid
5 Shilajit/Fulvic Acid
5 isoquercitrin
5 Mung Bean Sprouts
5 Lactoferrin/Talactoferrin
5 Magnetic Field Rotating
5 Phycocyanin
5 Ursolic acid
4 Isothiocyanates
4 Bacopa monnieri
4 Cichoric acid / Chicoric acid
4 Carvone
4 Ginkgo biloba-EGb 761
4 Formononetin
4 SDG/lignans
4 Ginkgo biloba
4 Geraniol
4 Ginkgetin
4 Isobavachalcone
4 Isorhamnetin
4 Lemongrass Extract/Citral
4 Methylene blue
4 nicotinamide adenine dinucleotide
4 Nimbolide
4 Patchouli Oil (Pogostemon cablin)
4 Taurine
4 Vitamin B5,Pantothenic Acid
4 Vitamin D3
4 Vitamin K2
3 Anethole/trans-Anethole
3 Baicalin
3 Biochanin A
3 Vitamin B12
3 Benzyl isothiocyanate
3 Bromelain
3 Black Rice, Oryza sativa
3 Lecithin
3 Carnosine
3 Camu camu
3 Chyawanprash
3 methotrexate
3 Spermidine
3 Cucurbitacin
3 Date Fruit Extract
3 Docosahexaenoic Acid
3 eicosapentaenoic acid
3 diet Fermented Foods
3 Exercise
3 Gamma-aminobutyric acid
3 Genistein (soy isoflavone)
3 HydroxyCitric Acid
3 Inositol
3 phytic acid, Inositol hexakisphosphate
3 Linalool
3 5-fluorouracil
3 Mangiferin
3 Marjoram (Origanum majorana)
3 Purple Corn / Purple Maize
3 α-Santalol/Sandalwood oil
3 Sulfasalazine
3 Sesamin
3 Vitamin B1/Thiamine
2 Anthocyanins
2 alpha Linolenic acid
2 Fennel Oil/Foeniculum vulgare
2 Allyl isothiocyanate
2 brusatol
2 borneol
2 buckwheat sprouts
2 Paclitaxel/Taxol
2 Cat’s Claw
2 Celecoxib
2 Chlorophyllin
2 Choline
2 Selenium
2 Vitamin E
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Galantamine
2 Huperzine A/Huperzia serrata
2 diet Short Term Fasting
2 Indole-3-carbinol
2 Dipyridamole
2 Echinacea
2 Eurycomanone
2 flavonoids
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 Ginkgolide B
2 Ginseng
2 Grapeseed extract
2 hydrogen sulfide
2 Orlistat
2 Hibiscus sabdariffa
2 Oleuropein
2 iodine
2 Inulin Prebiotic
2 isoflavones
2 Ivermectin
2 Juglone
2 Potassium
2 probiotics
2 Lutein
2 MBE, Maqui berry
2 Methyl salicylate / Sweet Birch oil
2 Metformin
2 Magnesium
2 Lemon Balm/Melissa officinalis
2 Naringin
2 Oleocanthal
2 Phenylbutyrate
2 Phosphatidylserine
2 Salvia officinalis
2 Shankhpushpi
2 Salvia miltiorrhiza
2 Terpinen-4-ol / Tea Tree Oil
2 Aflavin-3,3′-digallate
2 Turmerones
2 Zyflamend
1 2-DeoxyGlucose
1 5-Hydroxytryptophan
1 Annona atemoya Seed Extract
1 Açaí, Euterpe oleracea
1 Astragalus
1 Acetyl-l-carnitine
1 Aloe anthraquinones
1 beta-glucans
1 xanthohumol
1 Cannabidiol
1 beta-carotene(VitA)
1 Vitamin B6,pyridoxine
1 Bifidobacterium
1 Brucea javanica
1 Beetroot
1 Bruteridin(bergamot juice)
1 Black Seed Oil/Nigella sativa
1 Carnosic acid
1 Castalagin
1 Cannabichromene
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chaetocin
1 Prebiotic
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Copper and Cu NanoParticles
1 Rivastigmine
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Deguelin
1 Dihydrocaffeic Acid
1 diet Ketogenic
1 Diindolylmethane
1 Disulfiram
1 immunotherapy
1 Electrical Pulses
1 Evodiamine
1 Ascorbyl Palmitate
1 Flickering Light Stimulation
1 Iron
1 Galloflavin
1 Gambogic Acid
1 Ginkgolic acids
1 Bifidobacterium animalis subsp. lactis GCL2505
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Graviola
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 Helleborus niger extracts – Christmas Rose
1 Hops (Humulus lupulus)
1 Butein
1 Scopoletin
1 Lactobacillus
1 Zeaxanthin
1 Modified Citrus Pectin
1 irinotecan
1 MCT oil
1 Moringin
1 Mucuna pruriens/Velvet Bean
1 Mushroom Chaga, Inonotus obliquus
1 Nasturtium, Indian Cress
1 Neem
1 Oregano
1 Peppermint
1 Propyl gallate
1 Phenolic Acids
1 Propranolol
1 Psoralidin
1 Parthenolide
1 Pumpkin Seed Oil / Cucurbita pepo
1 Tamsulosin
1 EMF
1 Radio Frequency
1 Aromatherapy
1 Gold NanoParticles
1 Sesame seeds and Oil
1 Silicic Acid
1 Spirulina(Arthrospira/Limnospira)
1 cetuximab
1 Terminalia bellirica
1 Terpenoids
1 Thyme
1 Vitamin A, Retinoic Acid
1 Vitamin B2,Riboflavin
1 Walnut
1 Zinc
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:953  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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