Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
4832- EA,    Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid
*antiOx↑, *AntiCan↑, TumCMig↓, angioG↓, ChemoSen↑, RadioS↑, *chemoP↑, *BioAv↓, eff↓, selectivity↑, MMP2↓, MMP9↓, VEGF↓, TumCCA↑, Apoptosis↑, ROS↑, BioAv↑,
4341- EA,    Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation
- in-vitro, NA, NA
*AntiAg↑, *AntiAg↑,
3756- EA,    Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii
- Analysis, AD, NA
*AChE↓, *BACE↓, *MAOB↓,
2402- EA,    Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase
- in-vitro, NA, NA
PKL↓,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
1619- EA,  CUR,    Antimutagenic Effect of the Ellagic Acid and Curcumin Combinations
- in-vitro, Nor, NA
eff↑,
1617- EA,  CUR,    The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin
- in-vitro, Nor, NA
Dose∅, GSTs↓,
1606- EA,    Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells
- in-vitro, Colon, HCT15
TumCP↓, cycD1/CCND1↓, Apoptosis↑, PI3K↓, Akt↓, ROS↑, Casp3↑, Cyt‑c↑, Bcl-2↓, TumCCA↑, Dose∅, ALP↓, LDH↓, PCNA↓, P53↑, Bax:Bcl2↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
1610- EA,    Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer
- Review, Cerv, NA
TumCCA↑, STAT3↓, P21↑, IGFBP7↑, Akt↓, mTOR↓, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑,
1611- EA,    Targeting Myeloperoxidase Activity and Neutrophil ROS Production to Modulate Redox Process: Effect of Ellagic Acid and Analogues
- in-vitro, Mal, NA
*BioAv↓, eff↑, *BioAv↓, ROS↑,
1612- EA,    Negative Effect of Ellagic Acid on Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Cancer Cell
- in-vitro, EC, NA
NHE1↓, i-pH↓, ROS↓, GlucoseCon↓, NHE1↓, Glycolysis↓,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, eff↑, COX2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
1614- EA,    Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice
- Human, Nor, NA
*BioEnh↝, *Half-Life∅,
1615- EA,    Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers
- Human, Nor, NA
*BioAv∅, *ROS∅,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
1110- EA,  GEM,    Ellagic Acid Resensitizes Gemcitabine-Resistant Bladder Cancer Cells by Inhibiting Epithelial-Mesenchymal Transition and Gemcitabine Transporters
- vitro+vivo, Bladder, NA
TGF-β↓, SMAD2↓, SMAD3↓, SMAD4↓,
1037- EA,    Unripe Black Raspberry (Rubus coreanus Miquel) Extract and Its Constitute, Ellagic Acid Induces T Cell Activation and Antitumor Immunity by Blocking PD-1/PD-L1 Interaction
- in-vivo, CRC, NA
AntiTum↑, PD-L1↓,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2↓, Hif1a↓, VEGF↓, VEGFR2↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
6611- Ech,    Proliferative activity of a blend of Echinacea angustifolia and Echinacea purpurea root extracts in human vein epithelial, HeLa, and QBC-939 cell lines, but not in Beas-2b cell lines
- in-vitro, Cerv, HeLa - in-vitro, Nor, BEAS-2B - in-vitro, Nor, HUVECs
Imm↑, TumCP↑, Telomerase↓, Apoptosis↑, DNAdam↑, Casp9↑, cl‑PARP↑, β-catenin/ZEB1↓,
6603- Ech,  doxoR,    The effect of Echinacea purpurea on the pharmacokinetics of docetaxel
- Trial, Var, NA
other∅, other↝, Imm↑, CYP3A4⇅, other↑,
6604- Ech,    Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion
- Human, Nor, NA
*BioAv↑, *Half-Life↝, *Dose↝, Dose?,
6605- Ech,    Bioavailability of Echinacea Constituents: Caco-2 Monolayers and Pharmacokinetics of the Alkylamides and Caffeic Acid Conjugates
- Human, Nor, NA
*Imm↑,
6606- Ech,  Cic,    Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HCT116
TumCP↓, Telomerase↓, Apoptosis↑, DNAdam↑, Casp9↑, cl‑PARP↑, β-catenin/ZEB1↓, eff↑,
6607- Ech,    Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines
- in-vitro, PC, MIA PaCa-2 - in-vitro, CRC, Colo320
tumCV↓, eff↑, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, Imm↑, NK cell↑, PGE2↓, COX1↓, COX2↓, 5LO↓,
6608- Ech,  CBC,    The pro-apoptosis effects of Echinacea purpurea and Cannabis sativa extracts in human lung cancer cells through caspase-dependent pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, ROS↑, Casp3↑, TumCD↑,
6609- Ech,  Cic,    Echinacea purpurea Extract Enhances Natural Killer Cell Activity In Vivo by Upregulating MHC II and Th1-type CD4+ T Cell Responses
- in-vivo, Nor, NA
*Dose↝, *CD4+↑, *Th1 response↑, *NK cell↑, *Imm↑,
6610- Ech,  Cic,    A standardized extract of Echinacea purpurea containing higher chicoric acid content enhances immune function in murine macrophages and cyclophosphamide-induced immunosuppression mice
- in-vivo, Nor, NA
*NK cell↑, *Imm↑, Dose↝,
6614- Ech,    Echinacea: a Miracle Herb against Aging and Cancer? Evidence In vivo in Mice
- in-vivo, Var, NA
*Imm↑, *AntiAge↑, OS↑, NK cell↑, PGE2↓, 5LO↓, COX2↓, Dose↝, eff↑,
6612- Ech,    Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial
- Trial, Nor, NA
*Imm↑, Dose↝, eff↑,
6613- Ech,    Bioavailability and pharmacokinetics of Echinacea purpurea preparations and their interaction with the immune system
- Study, Nor, NA
*TNF-α↓, *IL8↓, Imm↑,
1057- EDM,    Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion
NF-kB↓, TNF-α↓, COX2↓, cycD1/CCND1↓, cMyc↓, MMP9↓, ICAM-1↓, MDR1↓, XIAP↓, Bcl-2↓, Bcl-xL↓, IAP1↓, IAP2↓, cFLIP↓, Bfl-1↓,
1022- EDM,    Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis
- in-vivo, Lung, H1975 - in-vitro, Lung, H1650
TumCG↓, Apoptosis↑, TumCCA↑, PD-L1↓, MUC1-C↓, TumVol↓,
1111- EDM,    Evodiamine exerts inhibitory roles in non‑small cell lung cancer cell A549 and its sub‑population of stem‑like cells
- in-vitro, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, EMT↓,
1012- EGCG,    Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations
- in-vitro, Nor, HEK293
*H2O2↑, *β-catenin/ZEB1↓, *TCF-4↓,
1036- EGCG,    Green Tea Catechin Is an Alternative Immune Checkpoint Inhibitor that Inhibits PD-L1 Expression and Lung Tumor Growth
- in-vitro, Lung, A549 - in-vitro, Lung, LU99
PD-L1↓, EGF↓, Akt↓,
1071- EGCG,    Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase
- in-vitro, Nor, NA
*GDH↓,
1072- EGCG,    Epigallocatechin gallate (EGCG) suppresses epithelial-Mesenchymal transition (EMT) and invasion in anaplastic thyroid carcinoma cells through blocking of TGF-β1/Smad signaling pathways
- in-vitro, Thyroid, 8505C
EMT↓, TumCI↓, TumCMig↓, TGF-β↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓,
1056- EGCG,    EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1α and NFκB, and VEGF expression
- vitro+vivo, BC, E0771
TumW↓, VEGF↓, Weight∅, Hif1a↓, NF-kB↓,
26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
BAD↓, cl‑PARP↑, Casp7↑, IκB↓, Ki-67↓, VEGF↓, EGFR↓, FGF↓, TGF-β↓, TNF-α↓, SCF↓, Bax:Bcl2↑, NF-kB↓, chemoP↑, ChemoSen↑, TumVol↓,
20- EGCG,    Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
- in-vivo, Liver, NA - in-vivo, Tong, NA
HH↓, Gli1↓, Smo↓, TNF-α↓, COX2↓, *antiOx↑, Hif1a↓, NF-kB↓, VEGF↓, STAT3↓, Bcl-2↓, P53↑, Akt↓, p‑Akt↓, p‑mTOR↓, EGFR↓, AP-1↓, BAX↑, ROS↑, Casp3↑, Apoptosis↑, NRF2↑, *H2O2↓, *NO↓, *SOD↑, *Catalase↑, *GPx↑, *ROS↓,
21- EGCG,    Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice
- in-vivo, Liver, NA
HH↓, PTCH1↓, Smo↓, Gli1↓, CD44↓, β-catenin/ZEB1↓,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, eff↑,
23- EGCG,    (-)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells
- in-vitro, Chon, SW1353 - in-vitro, Chon, CRL-7891
HH↓, Gli1↓, PTCH1↓, Bcl-2↓, BAX↑, TumCG↓,
24- EGCG,  GEN,  QC,    Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin
- in-vitro, Pca, 22Rv1
NQO1↑, P53↑, NQO2↑, chemoPv↑, TumCP↓, AR↓,
25- EGCG,  QC,    Quercetin Increased the Antiproliferative Activity of Green Tea Polyphenol (-)-Epigallocatechin Gallate in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
COMT↓, TumCP↑, TumCCA↑, Apoptosis↑,
989- EGCG,  Citrate,    In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
- in-vitro, HCC, NA - in-vivo, NA, NA
PFK↓, Glycolysis↓, lactateProd↓, GlucoseCon↓, TumCP↓, TumCCA↑, Casp3↑, cl‑PARP↑, Apoptosis↑, Casp8↑, Casp9↑, Cyt‑c↝, MMP↓, BAD↑, GLUT2↓, PKM2∅,

Showing Research Papers: 3001 to 3050 of 6612
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6612

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

NA↓, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   GSH↓, 1,   GSTs↓, 1,   GSTs↑, 1,   HO-1↓, 2,   HO-2↓, 1,   MAD↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 12,   TBARS↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   Bfl-1↓, 1,   EGF↓, 1,   MMP↓, 4,   OCR↓, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   AMPK↑, 1,   cMyc↓, 4,   CYP3A4⇅, 1,   ECAR↝, 1,   GlucoseCon↓, 3,   GLUT2↓, 1,   Glycolysis↓, 3,   lactateProd↓, 2,   LDH↓, 2,   PDH↝, 1,   PDK1?, 2,   PDK1↓, 1,   PFK↓, 1,   PKL↓, 1,   PKM2∅, 1,   SIRT1↓, 2,  

Cell Death ⓘ

Akt↓, 8,   Akt↑, 1,   p‑Akt↓, 3,   Apoptosis↑, 14,   BAD↓, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 7,   Bax:Bcl2↑, 4,   Bcl-2↓, 8,   Bcl-xL↓, 3,   Casp↑, 1,   Casp3↑, 10,   Casp7↑, 3,   Casp8↑, 2,   Casp9↑, 4,   cFLIP↓, 1,   Cyt‑c↑, 3,   Cyt‑c↝, 1,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 1,   HEY1↓, 1,   IAP1↓, 1,   IAP2↓, 1,   iNOS↓, 1,   MAPK↓, 2,   Mcl-1↓, 1,   MDM2↓, 1,   Myc↓, 1,   NOXA↑, 1,   PUMA↑, 1,   survivin↓, 3,   Telomerase↓, 3,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 1,   other∅, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   NQO2↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNAdam↑, 6,   P53↑, 6,   cl‑PARP↑, 7,   PCNA↓, 3,   SIRT6↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1/2/5/9↓, 1,   CDK2↓, 3,   CDK2↑, 1,   CDK4↓, 1,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 1,   cycE1↓, 1,   P21↑, 4,   p‑RB1↓, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   CDK8↓, 2,   CIP2A↓, 1,   CSCs↓, 1,   EMT↓, 5,   p‑ERK↓, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 5,   HH↓, 5,   IGFBP7↑, 1,   mTOR↓, 1,   mTOR⇅, 1,   p‑mTOR↓, 1,   Nanog↓, 1,   NOTCH↓, 4,   NOTCH1↓, 1,   NOTCH3↓, 1,   OCT4↓, 1,   P90RSK↓, 1,   PI3K↓, 4,   PTCH1↓, 3,   PTCH2↓, 1,   PTEN↑, 2,   SCF↓, 1,   Shh↓, 3,   Smo↓, 3,   STAT3↓, 4,   p‑STAT3↓, 2,   TumCG↓, 4,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

5LO↓, 2,   AP-1↓, 1,   Ca+2↝, 1,   E-cadherin↑, 2,   p‑FAK↓, 1,   GLI2↓, 2,   Ki-67↓, 2,   MMP2↓, 5,   MMP9↓, 6,   MUC1-C↓, 1,   NEDD9↓, 1,   PKCδ↓, 2,   Slug↓, 1,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 3,   p‑SMAD3↓, 1,   SMAD4↓, 2,   Snail↓, 5,   TGF-β↓, 6,   TGF-β↑, 1,   TSC1↑, 1,   TumCI↓, 5,   TumCMig↓, 5,   TumCP↓, 10,   TumCP↑, 2,   TumMeta↓, 2,   Twist↓, 2,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↓, 3,   Endoglin↑, 1,   Hif1a↓, 6,   VEGF↓, 8,   VEGFR2↓, 3,  

Barriers & Transport ⓘ

GLUT1↓, 1,   NHE1↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 3,   COX2↓, 9,   ICAM-1↓, 1,   IL6↓, 3,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 1,   IκB↓, 1,   JAK↓, 1,   NF-kB↓, 8,   p‑NF-kB↓, 1,   NK cell↑, 2,   PD-1↓, 1,   PD-L1↓, 4,   PGE2↓, 2,   TNF-α↓, 4,  

Cellular Microenvironment ⓘ

i-pH↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 6,   COMT↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 5,   Dose?, 1,   Dose↝, 4,   Dose∅, 4,   eff↓, 1,   eff↑, 14,   MDR1↓, 1,   RadioS↑, 6,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 2,   AR↓, 1,   AST↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 3,   IL6↓, 3,   Ki-67↓, 2,   LDH↓, 2,   Myc↓, 1,   PD-L1↓, 4,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   OS↑, 1,   TumVol↓, 2,   TumW↓, 1,   Weight∅, 1,  
Total Targets: 218

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   H2O2↓, 1,   H2O2↑, 1,   NRF2↓, 1,   ROS↓, 1,   ROS∅, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

GDH↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TCF-4↓, 1,  

Migration ⓘ

AntiAg↑, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   IL8↓, 1,   Imm↑, 5,   Inflam↓, 1,   NK cell↑, 2,   Th1 response↑, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,  

Protein Aggregation ⓘ

BACE↓, 1,   MAOB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 5,   BioAv↑, 2,   BioAv∅, 1,   BioEnh↑, 1,   BioEnh↝, 1,   Dose↝, 2,   Half-Life↝, 1,   Half-Life∅, 2,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   cardioP↑, 1,   chemoP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   toxicity∅, 4,  
Total Targets: 40

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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