Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
843- Gra,    Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling
- in-vitro, NMSC, A431 - in-vitro, NMSC, UW-BCC1 - in-vitro, Nor, NHEKn
TumCG↓, TumCCA↑, Cyc↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, Sufu↑, BAX↑, Bcl-2↓, *toxicity↓,
842- Gra,    Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola)
- in-vitro, NA, NA - in-vitro, Nor, NA
other↓, *toxicity↓,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
840- Gra,    Evaluation of cytotoxicity of aqueous extract of Graviola leaves on squamous cell carcinoma cell-25 cell lines by 3-(4,5-dimethylthiazol-2-Yl) -2,5-diphenyltetrazolium bromide assay and determination of percentage of cell inhibition at G2M phase of cell cycle by flow cytometry: An in vitro study
- in-vitro, SCC, SCC25
TumCCA↑, ATP↓,
839- Gra,    Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway
- in-vitro, Liver, HepG2
tumCV↓, Apoptosis↑, HSP70/HSPA5↑, GRP94↑, ER Stress↑, p‑PERK↑, p‑eIF2α↑, GRP78/BiP↑, CHOP↑,
838- Gra,    Antiproliferative activity of aqueous leaf extract of Annona muricata L. on the prostate, BPH-1 cells, and some target genes
- in-vitro, Pca, BPH1
BAX↑, Bcl-2↓, TumVol↓,
837- Gra,    Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. in normal and immortalized human cell lines
- in-vitro, BC, MDA-MB-435 - in-vitro, Nor, WRL68 - in-vitro, Nor, HaCaT
*toxicity↓,
836- Gra,    Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism
- vitro+vivo, PC, NA
Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,
835- Gra,    Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB
- in-vitro, Lung, A549
ROS↑, MMP↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, Apoptosis↑, TumCCA↑,
834- Gra,    Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review
- Review, NA, NA
EGFR↓, PI3K/Akt↓, NF-kB↓, JAK↓, STAT↓, Hif1a↓, GLUT1↓, GLUT4↓, ROS↑, Catalase↑, SOD↑, HO-1↑,
833- Gra,    Cytotoxic Effect of Annona muricata leaf extracts on tumor cell lines in vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Lung, A549
Apoptosis↑,
847- Gra,    Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I).
NADHdeh↓,
858- Gra,    Annona muricata leaves induce G₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑, BAX↑, Bcl-2↓, TumCMig↓, TumCI↓,
857- Gra,    The Value of Caspase-3 after the Application of Annona muricata Leaf Extract in COLO-205 Colorectal Cancer Cell Line
- in-vitro, CRC, COLO205
Casp3↑, tumCV↓,
856- Gra,    https://pubmed.ncbi.nlm.nih.gov/33048613/
- in-vitro, BC, MCF-7
TumCCA↑, ROS↑, Casp↑,
855- Gra,    Antiproliferative activity of ionic liquid-graviola fruit extract against human breast cancer (MCF-7) cell lines using flow cytometry techniques
- in-vitro, BC, MCF-7
TumCG↓, TumCP↓, TumCCA↑, Apoptosis↑,
854- Gra,  AgNPs,    Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy
- vitro+vivo, AML, THP1 - in-vitro, AML, AMJ13 - vitro+vivo, lymphoma, HBL
TumCP↓, TumAuto↑, IL1↓, NLRP3↓, Apoptosis↑, mtDam↑, P53↑, LDH↓,
853- Gra,  AgNPs,    Solid lipid nanoparticles of Annona muricata fruit extract: formulation, optimization and in vitro cytotoxicity studies
other↑,
852- Gra,    Silver Nanoparticles from Annona muricata Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool
- in-vitro, BC, MCF-7 - in-vitro, Colon, HCT116 - in-vitro, Melanoma, A375
tumCV↓,
851- Gra,    Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, CV1
Bcl-2↓, Casp9↑, Casp3↑, other↑, *toxicity↓,
850- Gra,    Selective cytotoxic and anti-metastatic activity in DU-145 prostate cancer cells induced by Annona muricata L. bark extract and phytochemical, annonacin
- in-vitro, PC, PC3 - in-vitro, Pca, DU145
ROS∅, MMP∅, Casp3↑, Casp7↑, VEGF↓,
849- Gra,    Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis
- in-vitro, Pca, PC3 - in-vitro, Nor, PNT1A - in-vitro, NA, HeLa
Casp9↑, CXCL1↓, *toxicity↓,
848- Gra,  AgNPs,    Synthesis, Characterization and Evaluation of Antioxidant and Cytotoxic Potential of Annona muricata Root Extract-derived Biogenic Silver Nanoparticles
- in-vitro, CRC, HCT116
ROS↑, PUMA↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑,
846- Gra,    Cytotoxic effect of Annona muricata Linn leaves extract on Capan-1 cells
- in-vitro, NA, Ca9-22
other↑,
1234- Gra,    Graviola attenuates DMBA-induced breast cancer possibly through augmenting apoptosis and antioxidant pathway and downregulating estrogen receptors
- in-vivo, BC, NA
Apoptosis↑, BAX↑, P53↑, Casp3↑, ER-α36↓, lipid-P↓,
1233- Gra,    THERAPEUTIC ELIGIBILITY OF GRAVIOLA VERSUS 5-FLUOROURACIL: APOPTOTIC EFFICACY ON HEAD AND NECK SQUAMOUS CELL CARCINOMA AND NORMAL EPITHELIUM CELLS
- in-vitro, HNSCC, NA
Apoptosis↑, MMP↓,
1232- Gra,    Graviola: A Systematic Review on Its Anticancer Properties
- Review, NA, NA
EGFR↓, cycD1/CCND1↓, Bcl-2↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, BAX↑, Cyt‑c↑, Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ATP↓,
2437- Gra,    Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity
- in-vitro, Pca, LNCaP - in-vitro, Pca, 22Rv1 - in-vitro, Pca, PC3 - in-vitro, Nor, PWR-1E
NOX↓, selectivity↑,
2438- Gra,    Emerging therapeutic potential of graviola and its constituents in cancers
- Review, Var, NA
Hif1a↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, MUC4↓, TumCCA↑, MMP↓, NF-kB↓, ROS↓, Bax:Bcl2↑, ER(estro)↓, cycD1/CCND1↓, chemoPv↑, hepatoP↑,
1118- GSE,    Grape Seed Proanthocyanidins Inhibit Migration and Invasion of Bladder Cancer Cells by Reversing EMT through Suppression of TGF- β Signaling Pathway
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, 5637
TumCMig↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Vim↓, Slug↓, E-cadherin↑, ZO-1↑, p‑SMAD2↓, p‑SMAD3↓, p‑Akt↓, p‑ERK↓, p‑p38↓,
1241- GSE,  PACs,    Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietin signaling
- in-vitro, Nor, NA
*VEGF↓, *MMP2↓, *MMP9↓, *p‑VEGFR2↓,
1240- GSE,  PACs,    Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, Hs294T
TumCMig↓, TumCI↓, COX2↓, PGE2↓, NF-kB↓, EMT↓, E-cadherin↑, Vim↓, Fibronectin↓, N-cadherin↓,
1292- GSE,  EGCG,    Antiproliferative and Apoptotic Effects Triggered by Grape Seed Extract (GSE) versus Epigallocatechin and Procyanidins on Colon Cancer Cell Lines
- in-vitro, Colon, Caco-2 - in-vitro, CRC, HCT8
TumCG↓, Apoptosis↑,
108- GSL,    A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, AsPC-1 - in-vitro, PC, C3H10T1/2
HH↓, Gli1↓, cycD1/CCND1↓, TumCP↓,
2511- H2,    Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation
- in-vivo, GBM, U87MG
TumCG↓, OS↑, CD133↓, Ki-67↓, angioG↓, Diff↑, TumCMig↓, TumCI↓, Dose↝, BBB↑, mt-ROS↑,
2525- H2,    Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis
- in-vivo, NA, NA
OS↓, cardioP↑, *AST↓, ALAT↓, *ROS↓, *MDA↓, *hepatoP↑, *Inflam↓, chemoP↑,
2524- H2,    Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy
- Trial, NA, NA
hepatoP↑, ALAT↓, AST↓, Dose↝, Dose↝,
2523- H2,    Prospects of molecular hydrogen in cancer prevention and treatment
- Review, Var, NA
ROS↓, TumCP↓, TumMeta↓, AntiTum↑, GutMicro↑, Inflam↓, OS↑, radioP↑, selectivity↑, SOD↑, IL1β↑, IL8↑, TNF-α↑, neuroP↑,
2522- H2,    A Systematic Review of Molecular Hydrogen Therapy in Cancer Management
- Review, Var, NA
chemoP↑, OS↑, QoL↑, TumVol↑, ROS↑, AntiTum↑, other↝,
2521- H2,    Oxyhydrogen Gas: A Promising Therapeutic Approach for Lung, Breast and Colorectal Cancer
- Review, CRC, NA - Review, Lung, NA - Review, BC, NA
Inflam↑, ROS↓, ChemoSen↑, p‑PI3K↓, p‑Akt↓, QoL↑, GutMicro↑, chemoP↑, radioP↑, *NRF2↑, *Catalase↑, *GPx↑, *HO-1↑, *SOD↑, *TNF-α↓, *IL4↓, *IL6↓, ChemoSen↑, Appetite↑, cognitive↑, Pain↓, Sleep↑, other?,
2520- H2,    The Impact of Molecular Hydrogen on Mitochondrial ROS and Apoptosis in Colorectal Cancer Cells
- in-vitro, CRC, NA
mt-ROS↓, ChemoSen↑, other↝,
2519- H2,    Hydrogen: an advanced and safest gas option for cancer treatment
- Review, Var, NA
antiOx↑, neuroP↓, BBB↑, toxicity∅, TumCP↓, Apoptosis↓, ROS↑, Hif1a↓, NF-kB↓, P53?, OS↑, chemoP↑,
2518- H2,    Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity
- in-vitro, BC, 4T1 - in-vitro, Nor, 3T3
TumCD↑, CD4+↑, ROS↓,
2517- H2,    Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response
- in-vitro, Var, A549 - in-vitro, NA, HCT116 - in-vitro, NA, HeLa - in-vitro, NA, HepG2 - in-vitro, NA, HT1080 - in-vitro, NA, PC3 - in-vitro, NA, SH-SY5Y
TumCP↓, other↝, eff↝, mt-UPR↑,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, eff↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
2515- H2,    Recent Advances in Studies of Molecular Hydrogen against Sepsis
- Review, Sepsis, NA
*Sepsis↓, *Inflam↓, *antiOx↑, *ROS↓, *NADPH↓,
2514- H2,    Hydrogen: A Novel Option in Human Disease Treatment
- Review, NA, NA
*Inflam↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↓, *TNF-α↓, *ROS↓, *HO-1↓, *NRF2↑, *ER Stress↓, H2O2↑,
2513- H2,    Hydrogen therapy: from mechanism to cerebral diseases
- Review, Stroke, NA
*BBB?, *antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Dose↝,
2512- H2,    Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch
- in-vivo, asthmatic, NA
selectivity↑, lactateProd↓, ATP↑, HK2↓, PFK↓, Hif1a↓, PGC-1α↑, Glycolysis↓, OXPHOS↑, Dose↝,
2510- H2,    Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
- in-vivo, Stroke, NA
*ROS↓, *antiOx↑,

Showing Research Papers: 3101 to 3150 of 5995
Prev Page 63 of 120 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5995

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   H2O2↑, 1,   HO-1↑, 1,   lipid-P↓, 2,   NADHdeh↓, 1,   OXPHOS↑, 1,   ROS↓, 4,   ROS↑, 9,   ROS∅, 1,   mt-ROS↓, 1,   mt-ROS↑, 1,   SOD↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 3,   ATP↑, 1,   MMP↓, 6,   MMP∅, 1,   mtDam↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 4,   lactateProd↓, 1,   LDH↓, 2,   LDHA↓, 3,   PFK↓, 1,   PI3K/Akt↓, 1,  

Cell Death ⓘ

p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 12,   BAX↑, 7,   Bax:Bcl2↑, 1,   Bcl-2↓, 7,   Casp↑, 2,   Casp∅, 1,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 5,   Cyt‑c↑, 4,   necrosis↑, 1,   p‑p38↓, 1,   PUMA↝, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other?, 1,   other↓, 1,   other↑, 3,   other↝, 3,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 1,   p‑PERK↑, 1,   mt-UPR↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

P53?, 1,   P53↑, 2,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

Cyc↓, 1,   cycD1/CCND1↓, 3,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   Diff↑, 1,   EMT↓, 2,   p‑ERK↓, 1,   Gli1↓, 2,   HH↓, 2,   p‑PI3K↓, 1,   Shh↓, 1,   Smo↓, 1,   STAT↓, 1,   Sufu↑, 1,   TumCG↓, 6,  

Migration ⓘ

E-cadherin↑, 2,   ER-α36↓, 1,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 1,   Ki-67↓, 2,   MMP2↓, 1,   MMP9↓, 2,   MUC4↓, 2,   N-cadherin↓, 2,   Slug↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 6,   TumMeta↓, 2,   Vim↓, 2,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EGFR↓, 2,   Hif1a↓, 6,   VEGF↓, 2,  

Barriers & Transport ⓘ

BBB↑, 2,   GLUT1↓, 4,   GLUT4↓, 4,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   COX2↓, 1,   CXCL1↓, 1,   IL1↓, 1,   IL1β↑, 1,   IL8↑, 1,   Inflam↓, 1,   Inflam↑, 1,   JAK↓, 1,   NF-kB↓, 6,   PGE2↓, 1,   TNF-α↑, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   Dose↝, 4,   eff↑, 2,   eff↝, 2,   selectivity↑, 5,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   AST↓, 1,   EGFR↓, 2,   GutMicro↑, 2,   Ki-67↓, 2,   LDH↓, 2,  

Functional Outcomes ⓘ

AntiTum↑, 2,   Appetite↑, 1,   cardioP↑, 1,   chemoP↑, 5,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   neuroP↓, 1,   neuroP↑, 1,   OS↓, 1,   OS↑, 4,   Pain↓, 1,   QoL↑, 2,   radioP↑, 3,   Sleep↑, 1,   toxicity∅, 1,   TumVol↓, 1,   TumVol↑, 1,  
Total Targets: 150

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 1,   GPx↑, 1,   HO-1↓, 1,   HO-1↑, 2,   MDA↓, 2,   NRF2↑, 3,   ROS↓, 6,   SOD↑, 2,  

Core Metabolism/Glycolysis ⓘ

NADPH↓, 1,  

Cell Death ⓘ

Apoptosis↓, 2,   Bax:Bcl2↓, 1,   cl‑Casp8↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Migration ⓘ

MMP2↓, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,   p‑VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB?, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↓, 1,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 5,   NF-kB↓, 1,   TNF-α↓, 3,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   Half-Life↓, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

AST↓, 1,   IL6↓, 3,  

Functional Outcomes ⓘ

cardioP↑, 1,   chemoP↑, 2,   hepatoP↑, 2,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 6,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 39

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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