Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
286- HCA,  ALA,    Adding a combination of hydroxycitrate and lipoic acid (METABLOC™) to chemotherapy improves effectiveness against tumor development: experimental results and case report
OS↑,
292- HCA,    Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway
- in-vitro, AML, K562
ACLY↓, AMPK↑, mTOR↑, eIF2α↑, ATFs↑, TumCG↓,
293- HCA,  Tam,    Hydroxycitric acid potentiates the cytotoxic effect of tamoxifen in MCF-7 breast cancer cells through inhibition of ATP citrate lyase
- in-vitro, BC, MCF-7
TumCG↓, Apoptosis↑, ACLY↓, ACC-α↓, Fas↓,
294- HCA,    In Vitro and In Vivo Toxicity of Garcinia or Hydroxycitric Acid: A Review

1415- HCA,    Hydroxycitrate delays early mortality in mice and promotes muscle regeneration while inducing a rich hepatic energetic status
- in-vivo, Nor, NA
*OS↑, *toxicity↓, *AST∅, *ALAT∅, *Strength↑, *memory∅, *other↑, *other↑, *other↑,
1414- HCA,    Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid
- Human, Nor, NA
*BioAv↑,
1413- HCA,    Effects of acute (-)-hydroxycitrate supplementation on substrate metabolism at rest and during exercise in humans
- Human, Nor, NA
*toxicity↓,
1412- HCA,    Identification of ATP Citrate Lyase as a Positive Regulator of Glycolytic Function in Glioblastomas
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
ACLY↓, TumCMig↓,
1637- HCA,  OLST,    Orlistat and Hydroxycitrate Ameliorate Colon Cancer in Rats: The Impact of Inflammatory Mediators
- in-vivo, Colon, NA
TumVol↓, OS↑, *IL6↓, *NF-kB↓, *eff↑, *Casp3↓, *TNF-α↓, *Catalase↑, *NO↓, *ROS↓, *Inflam↓, *Apoptosis↓,
1635- HCA,    Hydroxycitric acid prevents hyperoxaluric-induced nephrolithiasis and oxidative stress via activation of the Nrf2/Keap1 signaling pathway
- vitro+vivo, Nor, NA
*other↓, *ROS↓, *SOD↑, *Catalase↑, *MDA↓, *NRF2↑,
1589- HCA,    ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism
- Review, NA, NA
ACLY↓, eff↑,
1625- HCA,    In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase
- Review, Nor, NA
CRM↑, ACLY↓, TumAuto↑, Inflam↓, TumCG↓, toxicity∅, lipoGen↓, *ROS↓, *OCR↓,
1627- HCA,  CRMs,  Sper,    Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
- Review, Var, NA
ChemoSen↑, eff↑, ACLY↓, LC3‑Ⅱ/LC3‑Ⅰ↑, TumAuto↑, other↓,
1628- HCA,  ALA,    Addition of Hydroxy Citrate improves effect of ALA
- Review, Var, NA
ACLY↓, other↓, ROS↑, eff↑, PDKs↓,
1629- HCA,  Tam,    Hydroxycitric acid reverses tamoxifen resistance through inhibition of ATP citrate lyase
- in-vitro, BC, MCF-7
ACLY↓, eff↓, tumCV↓, eff↑, Casp3↑, BAX↑, Bcl-2↓,
1630- HCA,    Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia
- Review, NA, NA
ACLY↓, FASN↓, lipoGen↓, Weight↓,
1634- HCA,    Hydroxycitrate: a potential new therapy for calcium urolithiasis
- Human, Nor, NA
*other↑, *eff↑,
1633- HCA,    Hydroxycitric Acid Alleviated Lung Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis through the Hif-1α Pathway
- in-vivo, NA, NA - in-vitro, Nor, HUVECs
*other↓, *Inflam↓, *MDA↓, *ROS↓, *Iron↓, *SOD↓, *Hif1a↓, *HO-1↓,
1631- HCA,    An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management
- Review, Obesity, NA
*ACLY↓, *toxicity∅, *Dose∅,
1645- HCAs,    Chapter 8 - Hydroxycinnamic Acids: Natural Sources, Biosynthesis, Possible Biological Activities, and Roles in Islamic Medicine
- Review, Nor, NA
Dose∅, ROS⇅, Dose∅,
1657- HCAs,    Anticancer Activity of Sinapic Acid by Inducing Apoptosis in HT-29 Human Colon Cancer Cell Line 2023
- in-vitro, CRC, HT-29
cl‑Casp3↑, BAX↑, cl‑PARP↑, γH2AX↑, Cyt‑c↑,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27↑, P53↑, VEGF↓, MAPK↓,
1641- HCAs,    Lung cancer induced by Benzo(A)Pyrene: ChemoProtective effect of sinapic acid in swiss albino mice
- in-vitro, Lung, A549 - in-vivo, Lung, NA
AntiCan↑, Igs↓, lipid-P↓, ROS↑, Casp3↑, Casp9↑, ChemoSideEff↓, Dose∅,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
1644- HCAs,  PBG,    Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis
- in-vitro, Pca, LNCaP
NF-kB↓, TRAILR↑, Casp8↑, Casp3↑, MMP↓, Dose?,
1649- HCAs,    Anticancer Properties of Hydroxycinnamic Acids -A Review
- Review, Var, NA
*antiOx↑, MMP2↓, MMP9↓, VEGF↓, TGF-β↓, Bax:Bcl2↑, TumCCA↑, COX2↓, NF-kB↓,
2400- HCAs,    The Mixture of Ferulic Acid and P-Coumaric Acid Suppresses Colorectal Cancer through lncRNA 495810/PKM2 Mediated Aerobic Glycolysis
- in-vitro, CRC, NA - in-vivo, CRC, NA
PKM2↓, Glycolysis↓, TumCG↓,
2407- HCAs,    2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2
- in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
p‑PKM2↓, TumCG↓,
602- HCAs,    Prooxidant activity of hydroxycinnamic acids on DNA damage in the presence of Cu(II) ions: mechanism and structure-activity relationship
- Analysis, NA, NA
ROS↑, DNAdam↑,
1441- HCQ,  Chemo,    Case report: stage 4 pancreatic cancer to remission using paricalcitol and hydroxychloroquine in addition to traditional chemotherapy
- Case Report, GBM, NA
TumAuto↓, Remission↑,
1439- HCQ,    Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine
- in-vitro, Melanoma, NA - in-vitro, CRC, HCT116
TumAuto↓, eff↓, other↓,
1438- HCQ,  Chemo,    Adding Chloroquine to Conventional Treatment for Glioblastoma Multiforme
- Trial, GBM, NA
OS↑, *toxicity∅,
1912- HCQ,  TMZ,    Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy
- in-vivo, GBM, U87MG
LC3B-II↑, CHOP↑, cl‑PARP↑,
1160- HibSad,    Hibiscus sabdariffa anthocyanins are potential modulators of estrogen receptor alpha activity with favourable toxicology: a computational analysis using molecular docking, ADME/Tox prediction, 2D/3D QSAR and molecular dynamics simulation
- Analysis, NA, NA
ER(estro)↓,
1286- HNK,    The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells
- in-vitro, CLL, NA
Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-2↓, BAX↑,
1153- HNK,    Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vivo, NA, NA
tumCV↓, Apoptosis↑, TumCMig↓, TumCI↓, Bcl-2↓, EGFR↓, CD133↓, Nestin↓, Akt↓, ERK↓, Casp3↑, p‑STAT3↓, TumCG↓,
1154- HNK,  MET,    Honokiol inhibits the growth of hormone-resistant breast cancer cells: its promising effect in combination with metformin
- in-vitro, BC, MCF-7 - in-vitro, BC, SkBr3 - in-vitro, BC, MDA-MB-231
cl‑PARP↑, Bcl-2↓, ERα/ESR1↓,
2079- HNK,    Honokiol Microemulsion Causes Stage-Dependent Toxicity Via Dual Roles in Oxidation-Reduction and Apoptosis through FoxO Signaling Pathway
- in-vitro, Nor, PC12
*toxicity↝, *ROS↓, *ROS↑, *Dose⇅, *BioAv↑, *BioAv↓, *ROS⇅, *SOD↓, *toxicity↑,
2071- HNK,    Identification of senescence rejuvenation mechanism of Magnolia officinalis extract including honokiol as a core ingredient
- Review, Nor, HaCaT
*ROS↓, *antiOx↑, *AntiAge↑, *MMP↑, *ECAR↓, *Glycolysis↓, *PAR-2↓, *CXCL12↑, *BMAL1↑, *mt-ROS↓, *OXPHOS↓,
2072- HNK,    Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells
- in-vitro, Thyroid, NA
ROS↑, eff↓,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
2082- HNK,    Revealing the role of honokiol in human glioma cells by RNA-seq analysis
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
AntiCan↑, TumCP↑, TumAuto↑, Apoptosis↑, *BioAv↑, *neuroP↑, *NF-kB↑, MAPK↑, GPx4↑, Tf↑, BAX↑, Bcl-2↓, antiOx↑, Hif1a↓, Ferroptosis↑,
2081- HNK,    Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity
- in-vitro, Colon, RKO - in-vitro, Colon, HCT116 - in-vitro, Colon, SW48 - in-vitro, Colon, HT-29 - in-vitro, Colon, LS174T - in-vitro, Colon, HCT8 - in-vitro, Colon, SW480 - in-vivo, NA, NA
tumCV↓, ROS↑, Iron↑, GPx4↓, mtDam↑, Ferroptosis↑, TumVol↓, TumW↓,
2080- HNK,    Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells
- in-vitro, AML, THP1 - in-vitro, AML, U937 - in-vitro, AML, SK-HEP-1
tumCV↓, TumCCA↑, Ferroptosis↑, lipid-P↑, HO-1↑, GPx4∅,
1021- HNK,    Honokiol suppress the PD-L1 expression to improve anti-tumor immunity in lung cancer
- in-vivo, Lung, NA
PD-L1↓, T-Cell↑, CD4+↑, CD8+↑, TumCG↓,
1087- HNK,    Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of β-Catenin Signaling
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, Lung, H226
TumCMig↓, COX2↓, PGE2↓, NF-kB↓, p65↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓,
1119- HNK,    Honokiol inhibits epithelial—mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E‐cadherin axis
- vitro+vivo, BC, NA
EMT↓, MSCmark↓, EM↑, STAT3↓, Zeb1↓, E-cadherin↑,
1120- HNK,    Honokiol suppresses renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition and cancer stem cell properties through modulating miR-141/ZEB2 signaling
- vitro+vivo, RCC, NA
EMT↓, CSCs↓, TumCG↓, miR-141↑,
1004- HNK,  RAPA,    Honokiol downregulates PD-L1 expression and enhances antitumor effects of mTOR inhibitors in renal cancer cells
- in-vitro, RCC, NA
Apoptosis↑, TumCCA↑, ROS↑, PD-L1↓, IFN-γ↓,
960- HNK,    Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth
- vitro+vivo, BC, MCF-7 - vitro+vivo, BC, MDA-MB-231
OCR↑, ECAR↓, GlucoseCon↓, lactateProd↓, ATP↓, Glycolysis↓, Hif1a↓, GLUT1↓, HK2↓, PDK1↓, Apoptosis↑, LDHA↓,

Showing Research Papers: 3201 to 3250 of 6002
Prev Page 65 of 121 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6002

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↑, 1,   Ferroptosis↑, 3,   GPx↑, 1,   GPx4↓, 1,   GPx4↑, 1,   GPx4∅, 1,   GSH↑, 1,   HO-1↑, 1,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   NRF2↑, 1,   ROS↑, 9,   ROS⇅, 2,   SOD↑, 1,  

Metal & Cofactor Biology ⓘ

Tf↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   MMP↓, 2,   mtDam↑, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACC-α↓, 1,   ACLY↓, 9,   AMPK↑, 1,   CRM↑, 1,   ECAR↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   lipoGen↓, 2,   PDK1↓, 1,   PDKs↓, 1,   PKM2↓, 1,   p‑PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 7,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 6,   Bcl-xL↓, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 3,   Cyt‑c↑, 1,   Fas↓, 1,   Ferroptosis↑, 3,   MAPK↓, 1,   MAPK↑, 1,   p27↑, 1,   survivin↓, 1,   TRAILR↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 3,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

ATFs↑, 1,   CHOP↑, 1,   eIF2α↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 2,   TumAuto↓, 2,   TumAuto↑, 5,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 1,   cl‑PARP↑, 5,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↑, 1,   Cyc↓, 1,   P21↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CSCs↓, 1,   EMT↓, 3,   ERK↓, 1,   p‑ERK↑, 1,   GSK‐3β↓, 1,   MSCmark↓, 1,   mTOR↑, 1,   Nestin↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   TumCG↓, 8,  

Migration ⓘ

Ca+2↑, 1,   E-cadherin↑, 2,   EM↑, 1,   miR-141↑, 1,   MMP2↓, 3,   MMP9↓, 3,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 1,   TumCP↑, 1,   TumMeta↓, 1,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EGFR↓, 1,   Hif1a↓, 2,   VEGF↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   COX2↓, 3,   IFN-γ↓, 1,   Igs↓, 1,   Igs↑, 1,   Inflam↓, 2,   NF-kB↓, 4,   p65↓, 1,   PD-L1↓, 2,   PGE2↓, 1,   T-Cell↑, 1,  

Hormonal & Nuclear Receptors ⓘ

ER(estro)↓, 1,   ERα/ESR1↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   Dose?, 1,   Dose∅, 4,   eff↓, 4,   eff↑, 5,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   ERα/ESR1↓, 1,   PD-L1↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 2,   ChemoSideEff↓, 1,   OS↑, 3,   Remission↑, 1,   toxicity∅, 1,   TumVol↓, 3,   TumW↓, 2,   Weight↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 142

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↑, 2,   HO-1↓, 1,   Iron↓, 1,   MDA↓, 2,   NRF2↑, 1,   OXPHOS↓, 1,   ROS↓, 6,   ROS↑, 1,   ROS⇅, 1,   mt-ROS↓, 1,   SOD↓, 2,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   ALAT∅, 1,   BMAL1↑, 1,   ECAR↓, 1,   Glycolysis↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Casp3↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↑, 4,  

Migration ⓘ

CXCL12↑, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   NF-kB↑, 1,   PAR-2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 3,   Dose⇅, 1,   Dose∅, 1,   eff↑, 2,  

Clinical Biomarkers ⓘ

ALAT∅, 1,   AST∅, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   memory∅, 1,   neuroP↑, 1,   OS↑, 1,   Strength↑, 1,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 2,  
Total Targets: 50

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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