Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,
6386- Eug,    A comprehensive and systematic review on potential anticancer activities of eugenol: From pre-clinical evidence to molecular mechanisms of action
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, Inflam↝, TumCI↓, TumMeta↓, cycD1/CCND1↓, CycB/CCNB1↓, PCNA↓, NF-kB↓, Bcl-2↓, BAX↑, AIF↑, P21↑, P53↑, ChemoSen↑,
6387- Eug,    Anticancer and antibacterial effects of a clove bud essential oil-based nanoscale emulsion system
- in-vitro, Thyroid, NA - in-vitro, Nor, HEK293
chemoPv↑, TumCP↓, selectivity↑,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *eff↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6335- Eug,    Eugenol with antioxidant activity inhibits MMP-9 related to metastasis in human fibrosarcoma cells
- in-vitro, Nor, NA
*H2O2↓, *ROS↓, *lipid-P↓, MMP9↓, TIMP1↓, *ROS↓, *antiOx↑,
6336- Eug,    Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG
- in-vivo, GC, NA
Apoptosis?, Bcl-2↓, Cyt‑c↝, Casp↑, TumCI↓, angioG↓, MMPs↓, VEGF↓, VEGFR1↓, TIMP2↑, RECK↑,
6337- Eug,    Eugenol alleviated breast precancerous lesions through HER2/PI3K-AKT pathway-induced cell apoptosis and S-phase arrest
- in-vitro, BC, MCF-10AT
TumCP↓, TumCCA↑, HER2/EBBR2↓, Akt↓, PDK1↓, Bcl-2↓, NF-kB↓, BAD↓, cycD1/CCND1↓,
6338- Eug,    Tumor suppressive roles of eugenol in human lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCMig↓, TumCI↓, Akt↓, MMP2↓, *lipid-P↓, *COX2↓, *ROS↓, PI3K↓,
6339- Eug,    Induction of apoptosis by eugenol in human breast cancer cells
- in-vitro, BC, NA
TumCG↓, TumCP↓, TumCD↑, GSH↓, lipid-P↑,
6340- Eug,    Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
tumCV↓, E2Fs↓, survivin↓, NF-kB↓, cycD1/CCND1↓, P21↑, TumCP↓, Apoptosis↑, TumCI↓, angioG↓,
6341- Eug,    A Metabolomic Investigation of Eugenol on Colorectal Cancer Cell Line HT-29 by Modifying the Expression of APC, p53, and KRAS Genes
- NA, Colon, HT29
*antiOx↑, ROS↑, tumCV↓, P53↑, APC↑, KRAS↓, FAO↓, Glycolysis↓,
6325- Eug,    Anticancer Properties of Eugenol: A Review
- Review, Var, NA
*antiOx↑, *AntiCan↑, *Inflam↓, TumCD↑, TumCCA↑, TumCMig↓, TumMeta↓, angioG↓, ChemoSen↑, chemoP↑, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *Bacteria↓, *ROS↓, *IL6↓, *COX2↓, *TNF-α↓, *lipid-P↓, *SOD1↑, *Catalase↑, *GPx1↑, *GSTs↑, ROS↑, MMP↓, Apoptosis↑, COX2↓, TumCCA↑, E2Fs↓, PI3K↓, Akt↓, MMPs↓, CSCs↓, OCT4↓, CD44↓, EpCAM↓, NOTCH1↓, TumVol↓, Casp3↑, P53↑, cl‑PARP↑, MMP2↓, MMP9↓, TIMP1↑, ALDH↓, NF-kB↓, *toxicity↓,
6324- Eug,    Pharmacodynamic, pharmacokinetic, toxicity, and recent advances in Eugenol's potential benefits against natural and chemical noxious agents: A mechanistic review
- Review, Var, NA
*Inflam↑, *antiOx↑, *Apoptosis↑,
6323- Eug,    Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects
- Review, Var, NA - Review, Arthritis, NA
*AntiCan↑, *AntiDiabetic↑, *cardioP↑, *toxicity↝, *GutMicro↑, *neuroP↑, *BioAv⇅, *BioAv↝, *antiOx↑, *Inflam↑, *AntiArt↑, *TNF-α↓, *IL6↓, *IL10↓, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TAC↑, TumCMig↓, TumCI↓, Akt↑, FOXO3↑, Casp3↑, Casp9↑, P21↑, angioG↓, TumCI↓, Apoptosis↑, NF-kB↓, eff↑, eff↑, ChemoSen↑, NA↑, Casp3↑, Casp9↑, *AntiDiabetic↑, *glucose↓, *ROS↓, *Inflam↓, *MDA↓, *GSH↑, *BioAv↑,
6333- Eug,  Cisplatin,  Rad,    Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation
- in-vitro, Cerv, HeLa
TumCP↓, LDH↝, ChemoSen↑, RadioS↑, Casp3↑, BAX↑, Cyt‑c↑, Casp9↑, Bcl-2↓, COX2↓, IL1β↓, ROS↑, NF-kB↓, COX2↓, TumCCA↓, Thiols↓, GSH↓,
6332- Eug,    Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCP↓, MMP2↓, MMP9↓, TIMP1↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑,
6331- Eug,    Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
- in-vitro, BC, MDA-MB-231
Apoptosis↑, TumAuto↑, TumCP↓, Akt↑, FOXO3↑, P21↑, p27↑, Casp3↑, Casp9↑, LC3s↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, E2Fs↓, survivin↓, BAX↑, Cyt‑c↑,
6330- Eug,    Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement
- Review, Var, NA
TumCD↑, TumCCA↑, AntiCan↑, Apoptosis↑, angioG↓, TumCI↓, TumMeta↓, ChemoSen↑, ALDH↓, NF-kB↓, IL6↓, IL8↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Snail↓, E-cadherin↑, SOX2↓, ROS↑, PCNA↓, MMP1↓, Cyt‑c↑, LDH↑, CSCs↓, OCT4↓, NOTCH1↓, EpCAM↓, CD44↓, HER2/EBBR2↓, VEGF↓, TIMP2↑, eff↑, Ca+2↑, TumVol↓, DNAdam↑, GSH↓, H2O2↑, lipid-P↑,
5231- Ex,    Regular Physical Exercise Increase Of Growth Hormone (GH) And Insulin-Like Growth Factor-1 (IGF-1) Activity in Elderly Improve the Aging Process and Quality of Life: A Mini Review
- Human, Nor, NA
*GH↑, *IGF-1↑,
5232- Ex,    Resistance training effect on serum insulin-like growth factor 1 in the serum: a meta-analysis
- Review, Nor, NA
*IGF-1↑, *IGF-1↓,
5233- Ex,    The effect of resistance training on serum insulin-like growth factor 1(IGF-1): A systematic review and meta-analysis
- Review, Nor, NA
*IGF-1↑,
5234- Ex,    Intense Walking Exercise Affects Serum IGF-1 and IGFBP3
- Trial, Nor, NA
*IGF-1↓, *IGFBP3↓,
5235- Ex,    Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men
- Trial, Nor, NA
Insulin↓, IGF-1↓, IGFBP1↑, eff↑,
5230- Ex,    Effects of an acute maximal exercise bout on serum insulin-like growth factor-1 in adults with MDD
- Trial, Nor, NA
*IGF-1↑, Dose↝,
5057- Ex,    Exercise and the growth hormone–insulin-like growth factor axis
- Review, Nor, NA
*IGF-1↑,
5059- Ex,    Physical exercise, IGF-1 and cognition A systematic review of experimental studies in the elderly
- Review, Nor, NA
*IGF-1↑,
5055- Ex,    Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes
- Review, Var, NA
OS↑, IGF-1↓, IGFBP3↑, BRCA1↑, BRCA2↑, RAS↓, P53↑, HSPs↑, Leptin↓, Irisin↓, Resistin↓, NK cell↑, CRP↓, IL6↓, TNF-α↓, PGE1↓, COX2↓, *GSH↑, *Catalase↑, *SOD↑, *monoA↑, *EndoR↑, *testos↑, ROS↑, QoL↑, BMD↑, BowelM↑,
5056- Ex,    Exercise interventions and serum IGF-1 levels in older adults with frailty and/or sarcopenia: a systematic review and meta analysis
- Review, Nor, NA
*IGF-1↑,
5058- Ex,    The Role of Insulin-Like Growth Factor (IGF-1) Signaling During Physical Exercise: A Systematic Review
- Review, Nor, NA
*IGF-1↑,
5064- Ex,    Effect Of Exercise Intervention On Insulin, Igfs And Igfbps In Cancer Patients
- Review, Var, NA
IGF-1↓, IGF-2↓, Insulin↓,
5063- Ex,    A randomized controlled trial on the efficacy of supervised exercise training in reducing IGF-1 levels in breast cancer survivors of the Movis’ cohort
- Trial, BC, NA
IGF-1↓, IGFBP3↓,
5062- Ex,    The Influence of Exercise on the Insulin-like Growth Factor Axis in Oncology: Physiological Basis, Current, and Future Perspectives
- Review, Var, NA
IGF-1↑,
5061- Ex,    Role of physical exercise in modulating the insulin-like growth factor system for improving breast cancer outcomes: A meta-analysis
- Review, BC, NA
IGF-2↓, IGFBP1↓, HOMA↓, glucose∅, IGF-1∅, eff↑,
5060- Ex,    Exercise-induced modulation of IGF-1 in healthy, obese, and cancer populations: a systematic review and meta-analysis
- Review, Var, NA
*IGF-1↑, IGF-1↓, IGFBP3↑,
2143- Ex,    The association between physical activity and bladder cancer: systematic review and meta-analysis
- Review, Bladder, NA
Risk↓, Dose↝,
2144- Ex,    Physical activity, hormone replacement therapy and breast cancer risk: A meta-analysis of prospective studies
- Analysis, NA, NA
Risk↓, Dose?, eff↑,
2145- Ex,    Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies
- Analysis, Var, NA
Risk↓, Dose↝, eff↑,
2146- Ex,    A systematic review and meta-analysis of physical activity and endometrial cancer risk
- Review, Endo, NA
Risk↓, eff↑,
2147- Ex,    The association between physical activity and gastroesophageal cancer: systematic review and meta-analysis
- Review, GC, NA
Risk↓,
2148- Ex,    Effects of Exercise on Cancer Treatment Efficacy: A Systematic Review of Preclinical and Clinical Studies
- Review, Var, NA
ChemoSen↑,
2153- Ex,    The Impact of Exercise on Cancer Mortality, Recurrence, and Treatment-Related Adverse Effects
- Review, Var, NA
eff↑, BMD↑, cognitive↑, OS↑, Remission↑, eff↑,
2151- Ex,    The effects of physical activity on overall survival among advanced cancer patients: a systematic review and meta-analysis
- Review, Var, NA
eff↑, eff↝,
2150- Ex,    Roles and molecular mechanisms of physical exercise in cancer prevention and treatment
- Review, Var, NA
eff↓, Dose↝, TumCP↓, Apoptosis↓, ChemoSen↑, chemoP↑,
2149- Ex,    Physical activity and exercise training in cancer patients
- Analysis, Var, NA
eff↑, Dose↑,
3985- Ex,    The combined effect of physical activity and fruit and vegetable intake on decreasing cognitive decline in older Taiwanese adults
- Study, AD, NA
*cognitive↑,
4140- Ex,    Experimental and clinical evidence of physical exercise on BDNF and cognitive function: A comprehensive review from molecular basis to therapy
- Review, AD, NA
*BDNF↑, *cognitive↑,
4174- Ex,    Exercise-Mediated Neurogenesis in the Hippocampus via BDNF
- Review, NA, NA
*neuroP↑, *cognitive↑, *memory↑, *BDNF↑, *neuroG↑,
4155- Ex,    Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats
- in-vivo, AD, NA
*BDNF↑,
4137- Ex,    The impact of exercise on patients with dementia
- Trial, AD, NA
*Strength↑, *QoL↑, *cognitive∅,
4138- Ex,    Relationship Between Exercise and Alzheimer’s Disease: A Narrative Literature Review
- Review, AD, NA
*other↑, *Risk↓, *cognitive↑,

Showing Research Papers: 3301 to 3350 of 6624
Prev Page 67 of 133 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6624

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

CXCR3↓, 1,   NA↑, 1,  

Redox & Oxidative Stress ⓘ

GSH↓, 3,   H2O2↑, 1,   lipid-P↑, 2,   ROS↑, 6,   Thiols↓, 2,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   Insulin↓, 2,   MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

FAO↓, 1,   glucose∅, 1,   Glycolysis↓, 1,   LDH↑, 1,   LDH↝, 1,   PDK1↓, 2,  

Cell Death ⓘ

Akt↓, 4,   Akt↑, 2,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 8,   BAD↓, 2,   BAX↑, 6,   Bcl-2↓, 6,   Casp↑, 1,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↑, 3,   Cyt‑c↝, 1,   DR4↑, 1,   DR5↑, 1,   p27↑, 1,   survivin↓, 3,   TumCD↑, 3,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 3,  

Transcription & Epigenetics ⓘ

BowelM↑, 1,   tumCV↓, 4,  

Protein Folding & ER Stress ⓘ

HSPs↑, 1,  

Autophagy & Lysosomes ⓘ

LC3s↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 2,   P53↑, 6,   PARP↑, 1,   cl‑PARP↑, 2,   PCNA↓, 2,  

Cell Cycle & Senescence ⓘ

CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   E2Fs↓, 4,   P21↑, 4,   TumCCA↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 2,   CD44↓, 3,   CSCs↓, 3,   EMT↓, 1,   EpCAM↓, 3,   FOXO3↑, 2,   FOXO3↝, 1,   HRAS↓, 1,   IGF-1↓, 5,   IGF-1↑, 1,   IGF-1∅, 1,   IGF-2↓, 2,   IGFBP1↓, 1,   IGFBP1↑, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   mTOR↓, 1,   NOTCH1↓, 3,   OCT4↓, 3,   PI3K↓, 3,   RAS↓, 1,   SOX2↓, 1,   TumCG↓, 2,  

Migration ⓘ

APC↑, 1,   Ca+2↑, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   KRAS↓, 2,   MMP1↓, 1,   MMP2↓, 6,   MMP9↓, 6,   MMPs↓, 2,   N-cadherin↓, 1,   RECK↑, 2,   Snail↓, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↑, 3,   TumCI↓, 8,   TumCMig↓, 4,   TumCP↓, 8,   TumMeta↓, 5,   VEGFR1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 6,   VEGF↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   CRP↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↝, 1,   NF-kB↓, 9,   NK cell↑, 1,   PGE1↓, 1,   Resistin↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

Irisin↓, 1,   Leptin↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 7,   Dose?, 1,   Dose↑, 1,   Dose↝, 5,   eff↓, 1,   eff↑, 12,   eff↝, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

BMD↑, 2,   BRCA1↑, 1,   CRP↓, 1,   HER2/EBBR2↓, 3,   HOMA↓, 1,   IL6↓, 2,   Ki-67↓, 1,   KRAS↓, 2,   LDH↑, 1,   LDH↝, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   antiNeop↑, 1,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 1,   OS↑, 2,   QoL↑, 1,   Remission↑, 1,   Risk↓, 5,   TumVol↓, 2,  
Total Targets: 143

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiArt↑, 2,  

Redox & Oxidative Stress ⓘ

antiOx↑, 6,   Bil↓, 1,   Catalase↑, 4,   GPx↑, 3,   GPx1↑, 1,   GSH↑, 4,   GSTs↑, 2,   H2O2↓, 1,   lipid-P↓, 5,   MDA↓, 2,   NRF2↑, 1,   ROS↓, 6,   SOD↑, 3,   SOD1↑, 1,   TAC↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   glucose↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   iNOS↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

GH↑, 1,   IGF-1↓, 2,   IGF-1↑, 9,   IGFBP3↓, 1,   neuroG↑, 1,  

Migration ⓘ

CEA↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   IL10↓, 1,   IL1β↓, 1,   IL6↓, 3,   Inflam↓, 3,   Inflam↑, 2,   TNF-α↓, 4,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 3,   EndoR↑, 1,   monoA↑, 1,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 5,   BioAv⇅, 1,   BioAv↝, 2,   eff↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   Bil↓, 1,   CEA↓, 1,   GutMicro↑, 1,   IL6↓, 3,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 2,   cardioP↑, 2,   cognitive↑, 4,   cognitive∅, 1,   memory↑, 1,   neuroP↑, 3,   Pain↓, 1,   QoL↑, 1,   Risk↓, 1,   Strength↑, 1,   toxicity↓, 1,   toxicity↝, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 2,  
Total Targets: 63

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page