ERK Cancer Research Results

ERK, ERK signaling: Click to Expand ⟱
Source:
Type:
MAPK3 (ERK1)
ERK proteins are kinases that activate other proteins by adding a phosphate group. An overactivation of these proteins causes the cell cycle to stop.
The extracellular signal-regulated kinase (ERK) signaling pathway is a crucial component of the mitogen-activated protein kinase (MAPK) signaling cascade, which plays a significant role in regulating various cellular processes, including proliferation, differentiation, and survival. high levels of phosphorylated ERK (p-ERK) in tumor samples may indicate active ERK signaling and could correlate with aggressive tumor behavior

EEk singaling is frequently activated and is often associated with aggressive tumor behavior, treatment resistance, and poor outcomes.
Scientific Papers found: Click to Expand⟱
8868- MOR,  PacT,    Synergistic effect of morin and paclitaxel impedes cell proliferation through PI3K/AKT/STAT3 signaling axis inhibition in gastric cancer
- in-vitro, GC, HGC27
ChemoSen↑, ROS↑, MMP↓, Apoptosis↑, cFos↓, KRAS↓, p‑ERK↓, PI3K↓, Akt↓, STAT3↓, TumCP↓,
8866- MOR,    Morin Induces Heme Oxygenase-1 via ERK-Nrf2 Signaling Pathway
- in-vitro, Nor, NA
*HO-1↑, *NRF2↑, *ARE↓, *ERK↑, *ROS↓,
8883- MOR,  5-FU,    Morin Mitigates 5-Fluorouracil-Induced Nephrotoxicity by Activating Nrf2/HO-1 and FXR, and Suppressing ERK/VCAM-1 and NF-κB Pathways
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *Dose↝, *Urea↓, *creat↓, *ROS↓, *NRF2↑, *HO-1↑, *NR1H4↑, *RenoP↑, *TNF-α↓, *IL6↓, *ERK↓, *VCAM-1↓, *NF-kB↓, *chemoP↑,
8961- mushLions,    A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation
- in-vivo, CRC, NA
Apoptosis↑, TRAIL↑, TNFR 1↑, DR5↑, p‑Akt↓, p‑ERK↓, Hif1a↓, PCNA↓, NF-kB↓, TumCI↓, TumCMig↓, TumCP↓,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, Var, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2/PTGS2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
1128- Myr,    Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
- vitro+vivo, Ovarian, NA
MAPK↓, ERK↓, PI3K↓, Akt↓, p‑PARP↑, cl‑Casp3↑, Bax:Bcl2↑, TumCMig↓, SMAD3↓,
1799- NarG,    Naringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations based therapeutics
- Review, BC, NA
TumCCA↑, BioAv↑, Half-Life∅, TNF-α↓, Casp8↑, BAX↑, Bak↑, EGF↓, mTOR↓, PI3K↓, ERK↓, Akt↓, NF-kB↓, VEGF↓, angioG↓, antiOx↑, EMT↓, OS↑, MAPK↓, ChemoSen↑, MMP9↓, MMP2↓, ROS↑, ROS↑, GSH↓, Casp3↑, ROS↑,
1271- NCL,    Niclosamide inhibits ovarian carcinoma growth by interrupting cellular bioenergetics
- vitro+vivo, Ovarian, SKOV3
Wnt/(β-catenin)↓, mTOR↓, STAT3↓, NF-kB↓, NOTCH↓, TumCG↓, Apoptosis↑, MEK↓, ERK↓, mitResp↓, Glycolysis↓, ROS↑, JNK↑,
6491- Nimb,    Nanodelivery and anticancer effect of a limonoid, nimbolide, in breast and pancreatic cancer cells
- Review, PC, NA
eff↑, uPA↓, uPAR↓, p‑EGFR↓, VEGFR1↓, NF-kB↓, IKKα↓, MMP2↓, MMP9↓, TIMP2↑, TumCP↓, IGFR↓, Akt↓, ERK↓, TumCCA↓, BAX↑, BAD↑, FasL⇅, Cyt‑c↑, EPR↑,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
4647- OLEC,    Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer
- Review, Var, NA
*Inflam↓, AntiCan↑, *COX2/PTGS2↓, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓, TumCP↓, *AntiAg↑, mTOR↓, STAT3↓, ERK↓, p‑Akt↓, Bcl-2↓, ROS↑, PSA↓,
1811- Oxy,    Hyperbaric oxygen therapy and cancer—a review
- Review, Var, NA
toxicity∅, AntiTum↑, MAPK↑, ERK↓, ChemoSen↑, ChemoSen↑, RadioS↑,
2062- PB,    Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway
- in-vitro, Lung, H460 - in-vitro, Lung, H1792 - in-vitro, Lung, A549 - in-vitro, Lung, SK-LU-1 - in-vitro, Nor, HBE4-E6/E7
JNK↓, ERK↓,
2028- PB,    Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
- Review, Var, NA
HDAC↓, TumCCA↑, P21↑, Dose↝, Telomerase↓, IGFBP3↑, p‑p38↑, JNK↑, ERK↑, BAX↑, Casp3↑, Bcl-2↓, Cyt‑c↝, FAK↓, survivin↓, VEGF↓, angioG↓, DNArepair↓, TumMeta↓, HSP27↑, ASK1↑, ROS↑, eff↑, ER Stress↓, GRP78/BiP↓, CHOP/DDIT3↑, AR↓, other?,
3252- PBG,    Propolis Extract and Its Bioactive Compounds—From Traditional to Modern Extraction Technologies
- Review, Nor, NA
*Inflam↓, *TNF-α↓, *NF-kB↓, *MAPK↓, *ERK↓, *antiOx↑, *NRF2↑, *cardioP↑, *Glycolysis↑, *Ca+2↓, *HO-1↑, *NRF2↑, *neuroP↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
1674- PBG,  SDT,  HPT,    Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells
- in-vitro, PC, PANC1 - in-vitro, Nor, H6c7
tumCV↓, ROS↑, eff↑, Dose∅, selectivity↑, MMP↓, mtDam↑, cl‑PARP↑, p‑ERK↓, p‑JNK↑, p‑p38↑, eff↓, ChemoSen↑,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, ChemoSen↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
1661- PBG,    Propolis: a natural compound with potential as an adjuvant in cancer therapy - a review of signaling pathways
- Review, Var, NA
JNK↓, ERK↓, Akt↓, NF-kB↓, FAK↓, MAPK↓, PI3K↓, Akt↓, P21↑, p27/CDKN1B↑, TRAIL↑, BAX↑, P53↑, ERK↓, ChemoSen↑, RadioS↑, Glycolysis↓, HK2↓, PKM2↓, LDHA↓, PFK↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4943- PEITC,    Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation
- in-vitro, Ovarian, OVCAR-3
TumCD↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Akt↓, ERK↓, cMyc↓, p38↑, JNK↑, eff↓,
5187- PEITC,    Phenethyl Isothiocyanate Inhibits Migration and Invasion of Human Gastric Cancer AGS Cells through Suppressing MAPK and NF-κB Signal Pathways
- in-vitro, GC, AGS
TumMeta↓, ERK↓, MKK7↓, PKCδ↓, Rho↓, uPA↓, MMP2↓, MMP9↓, RAS↓, VEGF↓, FAK↓, iNOS↓, COX2/PTGS2↓, TumCP↓,
1164- PI,    Inhibition of T cell activation by the phytochemical piperine
- in-vitro, Nor, NA
*other↓, *CD25+↓, *IFN-γ↓, *IL2↓, *IL4↓, *IL17↓, *CD69↓, *CTLA-4↓, *p‑ERK↓, *IKKα↓,
1256- PI,    Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
- in-vitro, adrenal, PHEO - in-vivo, NA, NA
Apoptosis↑, ROS↑, TumCMig↓, TumCI↓, EMT↓, angioG↓, Necroptosis↑, MAPK↑, ERK↑,
1059- PI,    Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells
- in-vitro, Lung, A549 - in-vitro, BC, MDA-MB-231 - in-vitro, Liver, HepG2
EMT↓, p‑ERK↓, p‑SMAD2↓,
3589- PI,    Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models
- in-vivo, Arthritis, NA
*IL6↓, *MMP13↓, *PGE2↓, *AP-1↓, *Inflam↓, *5LO↓, *COX1↓, *COX2/PTGS2↓, *ERK↓, *BioEnh↑,
2995- PL,    Piperlongumine overcomes osimertinib resistance via governing ubiquitination-modulated Sp1 turnover
- in-vitro, Lung, H1975 - in-vitro, Lung, PC9 - in-vivo, NA, NA
Sp1/3/4↓, cMET↓, Apoptosis↑, Cyt‑c↑, p‑ERK↓, p‑Akt↓, TumCG↓,
2944- PL,    Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells
- in-vitro, Thyroid, IHH4 - in-vitro, Thyroid, 8505C - in-vivo, NA, NA
ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
5162- PLB,    Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells
- vitro+vivo, Melanoma, A172
TumCG↓, TumCCA↑, Apoptosis↑, P21↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDC2↓, CDC25↑, Bax:Bcl2↑, Casp9↑, ROS↑, JNK↑, ERK↑, eff↓,
4704- PTS,  Cisplatin,    Pterostilbene Sensitizes Cisplatin-Resistant Human Bladder Cancer Cells with Oncogenic HRAS
- in-vitro, Bladder, NA
PI3K↓, mTOR↓, P70S6K↓, MEK↑, ERK↑, ChemoSen↑, TumAuto↑,
3930- PTS,    A Review of Pterostilbene Antioxidant Activity and Disease Modification
- Review, Var, NA - Review, adrenal, NA - Review, Stroke, NA
*BioAv↑, *antiOx↑, *neuroP↑, *Inflam↓, *ROS↓, *H2O2↓, *GSH↑, *GPx↑, *GSR↑, *SOD↑, TumCG↓, PTEN↑, HGF/c-Met↓, PI3K↓, Akt↓, NF-kB↓, TumMeta↓, MMP2↓, MMP9↓, Ki-67↓, Casp3↑, MMP↓, H2O2↑, ROS↑, ChemoSen↑, *cardioP↑, *CDK2↓, *CDK4↓, *cycE/CCNE↓, *cycD1/CCND1↓, *RB1↓, *PCNA↓, *CREB↑, *GABA↑, *memory↑, *IGF-1↑, *ERK↑, TIMP1↑, BAX↑, Cyt‑c↑, Diablo↑, SOD2↑,
4827- QC,  CUR,    Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin
- Review, Var, NA
*AntiCan↑, *Inflam↓, *Bacteria↓, *AntiDiabetic↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *NRF2↑, *Trx↑, *IronCh↑, *MDA↑, cycD1/CCND1↓, PI3K↓, Casp3↑, BAX↑, ChemoSen↑, ROS↑, Synergy↑, MMP↓, Cyt‑c↑, Akt↓, ERK↓,
3353- QC,    Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
- in-vitro, Oral, KON - in-vitro, Nor, MRC-5
tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,
3350- QC,    Quercetin and the mitochondria: A mechanistic view
- Review, Var, NA
*antiOx↑, *Inflam↓, *NRF2↑, ROS⇅, *NRF2↑, *HO-1↑, *PPARα↑, *PGC-1α↑, *SIRT1↑, *ATP↑, ATP↓, ERK↓, cl‑PARP↑, Casp9↑, Casp8↑, BAX↑, MMP↓, Cyt‑c↑, Casp3↑, HSP27↓, HSP72↓, RAS↓, Raf↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
3372- QC,  FIS,  KAE,    Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
- Review, HNSCC, NA
ROCK1↑, TumCCA↓, HSPs↓, RAS↓, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Endon↑, MMP9↓, MMP2↓, MMP7↓, MMP-10↓, VEGF↓, NF-kB↓, p65↓, iNOS↓, COX2/PTGS2↓, uPA↓, PI3K↓, FAK↓, MEK↓, ERK↓, JNK↓, p38↓, cJun↓, FOXO3↑,
61- QC,    Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, ARPE-19
p‑PI3K↓, p‑Akt↓, p‑ERK↓, NF-kB↓, p38↓, ABCG2↓, CD44↓, CD133↓, CSCs↓,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, Synergy↑, HIF-1↓,
41- QC,    Quercetin induces mitochondrial-derived apoptosis via reactive oxygen species-mediated ERK activation in HL-60 leukemia cells and xenograft
- vitro+vivo, AML, HL-60
Casp8↑, Casp9↑, Casp3↑, ROS↑, ERK↑, cl‑PARP↑, MMP↓, eff↓,
95- QC,    Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent
- in-vitro, Pca, PC3
p‑ERK↓, p‑STAT3↓, p‑Akt↓, N-cadherin↓, Vim↓, cycD1/CCND1↓, Snail↓, Slug↓, Twist↓, PCNA↓, EGFR↓, chemoPv↑,
81- QC,  EGCG,    Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
- in-vivo, Pca, NA
COMT↓, MRP1/ABCC1↓, Ki-67↓, Bax:Bcl2↑, AR↓, Akt↓, p‑ERK↓, COMT↓, Synergy↑, chemoPv↑, BioAv↑,
80- QC,    Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway
- in-vitro, Pca, PC3
Vim↓, ERK↓, Snail↓, Slug↓, Twist↓, EGFR↓, p‑Akt↓, EGFR↓, N-cadherin↓, TumMeta↓, EMT↓,
910- QC,    The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism
- Review, Var, NA
tumCV↓, Apoptosis↑, PI3k/Akt/mTOR↓, Wnt/(β-catenin)↓, MAPK↝, ERK↝, TumCCA↑, H2O2↑, ROS↑, TumAuto↑, MMPs↓, P53↑, Casp3↑, Hif1a↓, cFLIP↓, IL6↓, IL10↓, lactateProd↓, Glycolysis↓, PKM2↓, GLUT1↓, COX2/PTGS2↓, VEGF↓, OCR↓, ECAR↓, STAT3↓, MMP2↓, MMP9:TIMP1↓, mTOR↓,
2329- RES,    Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis
- in-vitro, Melanoma, A375
P53↑, Bcl-2↓, BAX↑, Cyt‑c↑, ERK↓, PKM2↓, Apoptosis↑, γH2AX↑, Casp3↑, cl‑PARP1↑,
2443- RES,    Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review
- Review, Var, NA
*antiOx↑, *ROS↓, *PTEN↑, *Akt↓, *Catalase↑, *SOD↑, *ERK↓, *GSH↑, *AMPK↑, *FOXO1↝, *RNS↓, *Catalase↑, *cardioP↑, *PI3K↑, *eNOS↑, hepatoP↑,
2440- RES,    Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway
- in-vitro, Lung, H460 - in-vivo, Lung, NA - in-vitro, Lung, H1650 - in-vitro, Lung, HCC827
AntiTum↑, Glycolysis↓, HK2↓, EGFR↓, Akt↓, ERK↓, GlucoseCon↓, lactateProd↓, TumCG↓, Ki-67↓,
3084- RES,    Resveratrol inhibits the proliferation of estrogen receptor-positive breast cancer cells by suppressing EZH2 through the modulation of ERK1/2 signaling
- in-vitro, BC, MCF7 - in-vitro, BC, T47D
TumCP↓, EZH2↓, p‑ERK↓,

Showing Research Papers: 301 to 350 of 421
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 421

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 1,   antiOx↑, 10,   antiOx⇅, 1,   Catalase↓, 4,   Catalase↑, 1,   ENOX2↓, 1,   Fenton↑, 3,   GPx↓, 1,   GPx↑, 3,   GPx4↓, 4,   GSH↓, 20,   GSH↑, 4,   GSH/GSSG↓, 1,   GSR↑, 1,   H2O2↑, 4,   HO-1↓, 8,   HO-1↑, 7,   HO-2↓, 1,   Iron↑, 3,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 7,   lipid-P↑, 7,   MDA↓, 2,   MDA↑, 3,   NOX4↓, 1,   NQO1↑, 1,   NRF2↓, 11,   NRF2↑, 10,   NRF2↝, 1,   Prx6↑, 1,   PYCR1↓, 1,   ROS?, 2,   ROS↓, 29,   ROS↑, 143,   ROS⇅, 8,   i-ROS↓, 1,   i-ROS↑, 2,   SAM-e↝, 1,   SOD↓, 6,   SOD↑, 6,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 3,   Trx1↑, 1,   TrxR↓, 4,   TrxR1↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 3,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 8,   CDC2↑, 1,   CDC25↓, 11,   CDC25↑, 1,   compI↓, 1,   compIII↓, 1,   compV↓, 1,   CS↓, 1,   EGF↓, 6,   ETC↓, 1,   HSP60/HSPD1↓, 1,   Insulin↓, 1,   mitResp↓, 2,   MKK7↓, 1,   mtDam↓, 1,   mtDam↑, 7,   OCR↓, 3,   OCR↑, 1,   OXPHOS↑, 1,   PDH↓, 1,   PDH↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 2,   5LO↓, 1,   ACC↑, 1,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 4,   ALAT↝, 1,   AMPK↓, 1,   AMPK↑, 16,   p‑AMPK↑, 1,   ATP↓, 14,   CAIX/CA9↓, 1,   cAMP⇅, 1,   ECAR↓, 2,   ECAR↝, 1,   FABP5/E-FABP↓, 1,   FAO↑, 1,   FASN↓, 5,   FASN↑, 1,   G6PD↓, 1,   GAPDH↓, 1,   glucose↝, 1,   GlucoseCon↓, 5,   glut↓, 1,   GlutaM↓, 1,   Glycolysis↓, 20,   GSK‐3β↓, 6,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 4,   ac‑Histones↑, 1,   HK1↓, 1,   HK2↓, 11,   HMG-CoA↓, 1,   HSD17B4↓, 1,   lactateProd↓, 7,   lactateProd↑, 1,   LDHA↓, 2,   LDL↓, 1,   lipoGen↓, 1,   NAD↝, 1,   NADPH↓, 1,   O-Glc↓, 1,   PCK1↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 3,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 1,   PFK1↓, 2,   PFK2↓, 1,   PKM2↓, 8,   PKM2↑, 1,   p‑PKM2↓, 1,   Pyruv↓, 1,   p‑S6↓, 2,   SIRT1↓, 4,   SIRT1↑, 5,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   TCA↓, 1,   TumCM/A↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 8,   Apoptosis?, 1,   Apoptosis↓, 6,   Apoptosis↑, 146,   mt-Apoptosis↑, 2,   ASK1↑, 1,   BAD↓, 2,   BAD↑, 8,   Bak↑, 7,   BAX↓, 2,   BAX↑, 97,   BAX↝, 1,   Bax:Bcl2↑, 27,   Bcl-2↓, 103,   Bcl-2↑, 6,   Bcl-xL↓, 20,   BID↓, 2,   BID↑, 7,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 6,   BNIP3↑, 2,   Casp↑, 21,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp12?, 1,   Casp12↑, 1,   Casp2↑, 3,   Casp3↓, 6,   Casp3↑, 107,   cl‑Casp3↑, 19,   proCasp3↓, 1,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 13,   cl‑Casp7↑, 2,   Casp8↑, 34,   cl‑Casp8↑, 4,   Casp9↓, 1,   Casp9↑, 70,   cl‑Casp9↑, 9,   proCasp9↓, 1,   cFLIP↓, 7,   Cyt‑c↓, 1,   Cyt‑c↑, 65,   Cyt‑c↝, 2,   Diablo↑, 6,   DR5↑, 19,   Endon↑, 2,   FADD↑, 1,   Fas↑, 13,   FasL↑, 5,   FasL⇅, 1,   Ferroptosis↑, 7,   GranB/GZMB↑, 1,   GRP58↓, 1,   GSDME↑, 1,   IAP1↓, 5,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 16,   JWA↑, 1,   Mcl-1↓, 16,   p‑Mcl-1↓, 1,   MDM2↓, 8,   MDM2↑, 1,   p‑MDM2↓, 1,   Necroptosis↑, 3,   necrosis↑, 2,   NOXA↑, 2,   oncosis↑, 1,   p38↓, 16,   p38↑, 29,   p‑p38↓, 8,   p‑p38↑, 14,   p‑p38↝, 1,   Paraptosis↑, 1,   Perforin↑, 1,   PUMA↑, 2,   Pyro↑, 3,   RIP1↓, 2,   RIP1↑, 1,   RIP3↓, 1,   RIP3↑, 1,   survivin↓, 32,   TNFR 1↑, 2,   TRAIL↑, 5,   TRAILR↑, 1,   TumCD↑, 10,   XIAP↓, 15,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 137,   Akt↑, 2,   Akt↝, 2,   Akt∅, 1,   p‑Akt↓, 48,   p‑Akt↑, 4,   AKT1↓, 1,   Akt2↓, 1,   BRAF↓, 1,   BRAF↝, 1,   CaMKII ↓, 1,   CaMKII ↑, 1,   CK2↓, 3,   cMET↓, 6,   p‑cMET↓, 1,   p‑cMET↑, 2,   CREB↓, 1,   p‑CREB↓, 1,   cSrc↓, 3,   EGFR↓, 49,   p‑EGFR↓, 4,   EphB4↓, 1,   ERK↓, 195,   ERK↑, 41,   ERK↝, 4,   ERK∅, 1,   p‑ERK↓, 80,   p‑ERK↑, 22,   p‑ERK⇅, 2,   p‑ERK↝, 2,   e-ERK↑, 1,   FGFR1↓, 2,   FOXD3↑, 1,   HER2/EBBR2↓, 9,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   IGF-1R↓, 3,   IGFR↓, 2,   IKKα↓, 5,   IKKα↑, 2,   IKKα↝, 1,   p‑IKKα↓, 2,   IR↓, 1,   p‑IκB↓, 2,   JAK↓, 4,   p‑JAK↓, 1,   JAK1↓, 4,   JAK2↓, 11,   JNK↓, 14,   JNK↑, 34,   JNK↝, 1,   p‑JNK↓, 9,   p‑JNK↑, 15,   p‑JNK↝, 1,   cl‑JNK↑, 1,   MAP2K1/MEK1↓, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 39,   MAPK↑, 21,   MAPK↝, 4,   p‑MAPK↓, 4,   p‑MAPK↑, 2,   MEK↓, 19,   MEK↑, 2,   p‑MEK↓, 6,   p‑MEK↑, 1,   MKK4↓, 1,   mTOR↓, 48,   p‑mTOR↓, 6,   mTORC2↓, 1,   p70S6↓, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,   P70S6K↓, 6,   p‑P70S6K↓, 2,   p‑P90RSK↑, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 88,   PI3K↑, 1,   PI3K↝, 2,   p‑PI3K↓, 3,   PI3K/Akt↓, 5,   PI3K/Akt↑, 1,   PI3K/Akt↝, 1,   PI3k/Akt/mTOR↓, 2,   PIK3CA↓, 1,   p‑PIK3R1↓, 1,   PKCδ↓, 15,   PKCδ↑, 1,   p‑PKCδ↓, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↑, 19,   PTEN↝, 1,   p‑PTEN↓, 1,   PTK2B / PYK2↓, 1,   Raf↓, 12,   RAS↓, 16,   RAS↑, 1,   p‑RSK↓, 1,   S6K↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 9,   Src↓, 2,   STAT↓, 3,   p‑STAT↓, 1,   STAT3↓, 52,   STAT3↝, 1,   p‑STAT3↓, 12,   p‑STAT3↑, 1,   STAT5↓, 1,   p‑STAT5↓, 1,   STAT6↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF3↑, 1,   ATF4↑, 6,   cJun↓, 6,   cJun↑, 1,   p‑cJun↓, 1,   p‑cJun↑, 2,   cMyc↓, 26,   p‑cMyc↑, 1,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMTs↓, 3,   EZH2↓, 1,   FOXM1↓, 3,   FOXO↓, 1,   FOXO↑, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 5,   p‑FOXO3↓, 1,   FOXO4↑, 2,   ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   HATs↑, 2,   HDAC↓, 11,   HDAC1↓, 3,   HDAC2↓, 1,   HDAC4↓, 1,   HES1↓, 1,   JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-10b-5p↓, 1,   miR-139-5p↑, 1,   miR-155↓, 2,   miR-182-5p↓, 1,   miR-200b↑, 2,   miR-203↓, 1,   miR-203↑, 1,   miR-21↓, 3,   miR-21↑, 1,   miR-210↓, 1,   miR-210↑, 1,   miR-22↑, 1,   miR-224↓, 1,   miR-29b↑, 1,   miR-340↓, 1,   miR-34a↑, 3,   miR-384↑, 1,   miR-422a↑, 1,   miR-590-3p↑, 1,   miR-592↑, 1,   MITF↓, 1,   Myc↓, 4,   n-MYC↓, 1,   NDRG1↑, 1,   OCT4↓, 5,   other?, 2,   other↓, 4,   other↑, 4,   other↝, 6,   SOX2↓, 4,   SOX4↓, 1,   SOX9↓, 1,   SUV39H↓, 1,   TCF-4↓, 1,   TFAP2A↓, 1,   tumCV↓, 43,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   cl‑ATF6↑, 2,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 17,   eIF2α↓, 2,   eIF2α↑, 4,   p‑eIF2α↑, 4,   ER Stress↓, 2,   ER Stress↑, 25,   Erlin1↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 10,   GRP94↑, 1,   HSP27↓, 4,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP72↓, 1,   HSP90↓, 5,   HSPs↓, 2,   IRE1↑, 2,   PERK↑, 3,   p‑PERK↑, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 5,   XBP-1↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 5,   ATG7↑, 3,   Beclin-1/ATG6↑, 10,   CTSB↓, 1,   CTSD↓, 1,   LAMP2↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 4,   LC3I↑, 1,   LC3II↓, 2,   LC3II↑, 10,   lysoMP↑, 1,   p62↓, 5,   p62↑, 3,   RUBCN↓, 1,   TumAuto↑, 27,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DNAdam↓, 2,   DNAdam↑, 39,   DNArepair↓, 4,   ERCC3↑, 1,   HR↓, 1,   hTERT/TERT↓, 9,   p16↑, 2,   P53?, 1,   P53↓, 3,   P53↑, 58,   P53↝, 3,   P53∅, 1,   p‑P53↑, 4,   ac‑P53↑, 1,   PARP↓, 3,   PARP↑, 12,   p‑PARP↑, 2,   cl‑PARP↑, 56,   PARP1↑, 2,   cl‑PARP1↑, 2,   PCNA↓, 19,   RAD51↓, 1,   SAPK↑, 1,   SIRT6↑, 1,   Telomerase↓, 13,   TOP1↓, 4,   TOP2↓, 6,   TOP2↑, 1,   TP53↑, 2,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 14,   p‑CDK1↓, 1,   CDK2↓, 23,   CDK2↑, 1,   CDK4↓, 25,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK4/6↓, 1,   CDK6↓, 11,   CDK6↑, 2,   CDK8↓, 1,   CHK1↓, 2,   p‑CHK1↑, 2,   Chk2↓, 2,   p‑Chk2↓, 1,   p‑Chk2↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 20,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 55,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 11,   cycE/CCNE↑, 1,   cycE1↓, 1,   E2Fs↓, 2,   E2Fs↑, 1,   GADD45A↓, 1,   Ki-67↓, 19,   mitA↑, 1,   P21↓, 6,   P21↑, 42,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 23,   pRB↓, 2,   pRB↑, 1,   p‑pRB↓, 7,   RB1↓, 1,   RB1↑, 3,   p‑RB1↓, 4,   Securin↓, 2,   TumCCA↓, 5,   TumCCA↑, 110,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 3,   ALDH1A1↓, 3,   BMP2↓, 1,   BMPs↑, 2,   CD133↓, 7,   CD24↓, 3,   cFos↓, 6,   p‑cFos↓, 1,   cMYB↓, 2,   CSCs?, 1,   CSCs↓, 14,   Diff↓, 1,   Diff↑, 3,   FGF↓, 2,   Gli1↓, 1,   GREM1↓, 1,   HH↓, 1,   IGF-1↓, 10,   IGFBP3↑, 4,   JAG1↓, 1,   Jun↓, 1,   p‑Jun↑, 1,   Ki-67↓, 19,   Let-7↑, 2,   LGR5↓, 1,   Mel↓, 1,   mTORC1↓, 4,   p‑mTORC1↓, 1,   Nanog↓, 5,   Nestin↓, 3,   NICD↓, 1,   NOTCH↓, 11,   NOTCH1↓, 6,   NOTCH1↑, 1,   Piezo1↑, 1,   Shh↓, 3,   Smo↓, 1,   TAZ↓, 1,   TumCG↓, 54,   TumCP?, 1,   TumCP↓, 106,   TumCP↑, 1,   TumCP∅, 1,   tyrosinase↓, 1,   Wnt↓, 31,   Wnt/(β-catenin)↓, 9,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 14,   AP-1↑, 2,   BACH1↓, 1,   CA↓, 1,   Ca+2↓, 2,   Ca+2↑, 21,   Ca+2↝, 1,   mt-Ca+2↑, 1,   cal2↓, 1,   cal2↑, 1,   Cdc42↓, 1,   Cdc42↑, 1,   Cofilin↓, 1,   DLC1↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 28,   EM↑, 1,   EMMPRIN↓, 1,   EMT↓, 43,   EMT↑, 3,   F-actin↓, 1,   FAK↓, 17,   p‑FAK↓, 5,   p‑FAK↑, 1,   fascin↓, 2,   Fibronectin↓, 3,   Furin↓, 1,   IQGAP3↓, 1,   ITGA5↓, 3,   ITGB1↓, 4,   ITGB1↑, 1,   ITGB4↓, 1,   ITGB6↓, 1,   KRAS↓, 3,   LAMs↓, 2,   MET↓, 2,   MMP-10↓, 3,   MMP1↓, 8,   MMP13↓, 2,   MMP16↓, 1,   MMP2↓, 73,   MMP3↓, 4,   MMP7↓, 9,   MMP9↓, 86,   pro‑MMP9↓, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 18,   MUC1↓, 1,   N-cadherin↓, 20,   NCAM↑, 1,   NFAT↑, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 5,   Rac1↓, 2,   Rho↓, 5,   Rho↑, 1,   ROCK1↓, 2,   ROCK1↑, 2,   Sharpin↓, 1,   Slug↓, 9,   Smad1↑, 1,   Smad1↝, 1,   p‑SMAD2↓, 3,   SMAD3↓, 2,   p‑SMAD3↓, 2,   SMAD4↓, 2,   Snail↓, 15,   TET1↓, 1,   TET1↑, 1,   TGF-β↓, 13,   TGF-β↝, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 7,   TIMP2↓, 2,   TIMP2↑, 7,   TIMP3↑, 1,   TSC1↑, 1,   TSP-1↑, 3,   TumCA↓, 2,   TumCI↓, 59,   TumCI↑, 1,   TumCMig↓, 68,   TumCMig↑, 2,   TumMeta↓, 44,   TumMeta↑, 1,   Twist↓, 18,   uPA↓, 20,   uPAR↓, 2,   Vim↓, 24,   Zeb1↓, 6,   ZEB2↓, 2,   β-catenin/ZEB1↓, 38,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 52,   angioG↑, 3,   angioS↑, 1,   CD31/PECAM-1↓, 2,   ECM/TCF↓, 1,   EGR1↑, 1,   Endoglin↑, 1,   HIF-1↓, 5,   Hif1a↓, 40,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 5,   NO↑, 3,   PHDs↓, 1,   VCAM-1↓, 2,   VEGF↓, 77,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 15,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CellMemb↑, 1,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN2↓, 1,   CTR1↑, 1,   EPR↑, 2,   GLUT1↓, 5,   GLUT4↓, 1,   IBI↑, 1,   memfluid↓, 1,   MMP↓, 82,   MMP↑, 1,   MPT↑, 2,   NHE1↓, 2,   OCLN↑, 1,   TJ↑, 1,   TRPM7↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCR7↓, 1,   CD25+↑, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 9,   p‑cDC2↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 60,   COX2/PTGS2↑, 3,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR4↓, 12,   DR4↑, 5,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 5,   IFN-γ↑, 4,   IL1↓, 7,   IL1↑, 1,   IL10↓, 6,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1α↓, 2,   IL1β↓, 14,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 5,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL4↑, 2,   IL6↓, 31,   IL6↑, 1,   IL8↓, 7,   IL8↑, 1,   Imm↑, 5,   Imm↝, 2,   Inflam↓, 27,   M2 MC↓, 1,   MCP1/CCL2↓, 6,   MDSCs↓, 1,   MIP2↓, 3,   NF-kB?, 1,   NF-kB↓, 113,   NF-kB↑, 4,   NF-kB↝, 3,   p‑NF-kB↑, 2,   NK cell↑, 5,   NLRP3↓, 1,   NLRP3↑, 1,   p50↓, 1,   p65↓, 8,   PD-1↓, 1,   PD-L1↓, 6,   PGD2↓, 1,   PGE2↓, 20,   PSA↓, 7,   SOCS1↑, 1,   T-Cell↑, 2,   TCF↓, 1,   TCF↑, 1,   TLR1↑, 1,   TLR2↑, 1,   TLR4↓, 3,   TLR4↑, 1,   TLR4↝, 1,   TNF-α↓, 30,   TNF-α↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↓, 1,   IM↓, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 13,   COMT↓, 2,   ER-α36↓, 1,   ERα/ESR1↓, 1,   PPARα↓, 2,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 3,   BioAv↓, 24,   BioAv↑, 22,   BioAv↝, 4,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↓, 2,   ChemoSen↑, 87,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 3,   CYP1A1↑, 2,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 4,   Dose↓, 3,   Dose↑, 5,   Dose↝, 26,   Dose∅, 11,   eff?, 1,   eff↓, 26,   eff↑, 43,   eff↝, 8,   eff∅, 1,   GSTA1↑, 1,   Half-Life↓, 4,   Half-Life↑, 1,   Half-Life↝, 9,   Half-Life∅, 1,   MDR1↓, 3,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↝, 1,   P450↓, 2,   RadioS↑, 31,   selectivity?, 2,   selectivity↑, 48,   Synergy↑, 58,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 4,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 13,   ascitic↓, 1,   AST↓, 2,   AST↝, 1,   BMD↑, 1,   BRAF↓, 1,   BRAF↝, 1,   BRCA1↓, 2,   BRCA1↑, 1,   p‑BRCA1↑, 1,   CRP↓, 2,   E6↓, 3,   E7↓, 3,   EGFR↓, 49,   p‑EGFR↓, 4,   ERα/ESR1↓, 1,   EZH2↓, 1,   FOXM1↓, 3,   HER2/EBBR2↓, 9,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 9,   IL6↓, 31,   IL6↑, 1,   KRAS↓, 3,   LDH↓, 3,   LDH↑, 1,   Maspin↑, 1,   Myc↓, 4,   PD-L1↓, 6,   PSA↓, 7,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 32,   AntiCan∅, 1,   antiD↑, 1,   antiNeop↑, 4,   AntiTum↓, 1,   AntiTum↑, 12,   cachexia↓, 1,   cardioP↑, 9,   chemoP↓, 1,   chemoP↑, 22,   chemoPv↑, 10,   ChemoSideEff↓, 7,   ChemoSideEff∅, 1,   cognitive?, 1,   hepatoP↑, 9,   neuroP↑, 5,   NP/CIPN↓, 1,   OS↑, 7,   Pain↓, 1,   QoL↑, 2,   radioP↑, 7,   Remission↑, 1,   RenoP↑, 5,   Risk↓, 8,   toxicity↓, 8,   toxicity↝, 2,   toxicity∅, 4,   TumVol↓, 13,   TumW↓, 7,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiP↑, 1,   Bacteria↓, 1,   GutMicro↑, 5,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 937

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 2,   antiOx↓, 2,   antiOx↑, 62,   ARE↓, 1,   ARE↑, 1,   Catalase↑, 31,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 20,   GPx1↑, 1,   GPx4↑, 3,   GSH↓, 1,   GSH↑, 32,   GSR↑, 4,   GSSG↓, 1,   GSTs↑, 10,   H2O2↓, 2,   H2O2↑, 1,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 2,   HO-1↓, 3,   HO-1↑, 31,   Iron↓, 2,   i-Iron↓, 1,   Keap1↓, 4,   Keap1↑, 1,   Keap1↝, 1,   lipid-P?, 1,   lipid-P↓, 15,   MDA↓, 19,   MDA↑, 1,   MPO↓, 3,   NADH↓, 1,   NOX4↓, 1,   NQO1↑, 2,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 43,   Prx↑, 1,   RNS↓, 3,   ROS?, 1,   ROS↓, 79,   ROS↑, 1,   ROS⇅, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   SOD↑, 39,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 2,   Trx↑, 1,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTL↓, 1,   IronCh↑, 4,   IronCh↝, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compIII↑, 1,   compV↑, 1,   DRP1/DNM1L↓, 1,   p‑DRP1/DNM1L↝, 1,   Insulin↑, 1,   MFN1↝, 1,   MFN2↑, 1,   MFN2↝, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 5,   ACSL4↓, 1,   adiP↑, 1,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 7,   p‑AMPK↑, 1,   ATP↑, 4,   Buty↑, 1,   cAMP↑, 3,   CRM↑, 1,   glucose↓, 1,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 2,   Glycolysis↑, 1,   GSK‐3β↓, 6,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   HMG-CoA↓, 1,   LDL↓, 3,   lipidLev↓, 1,   NADPH↓, 2,   SCFAs↑, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   APAF1↓, 1,   Apoptosis↓, 8,   BAD↓, 1,   BAX↓, 3,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp3↓, 12,   Casp3∅, 1,   Casp6↓, 1,   Casp9↓, 4,   Casp9∅, 1,   Cyt‑c∅, 2,   Fas↓, 1,   Ferroptosis↓, 3,   iNOS↓, 14,   iNOS↑, 2,   necrosis↓, 2,   p38↓, 8,   p38↑, 2,   p‑p38↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 18,   p‑Akt↓, 1,   p‑Akt↑, 5,   e-Akt↑, 1,   Akt2↓, 1,   AMPKα↑, 1,   CREB↓, 1,   CREB↑, 8,   p‑CREB↑, 4,   EGFR↓, 1,   ERK↓, 29,   ERK↑, 31,   p‑ERK↓, 11,   p‑ERK↑, 11,   e-ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 3,   IκB↓, 1,   p‑IκB↓, 1,   JAK2↓, 1,   JNK↓, 10,   JNK↑, 1,   p‑JNK↓, 5,   p‑JNK↑, 2,   MAPK↓, 17,   MAPK↑, 7,   p‑MAPK↓, 1,   p‑MEK↓, 1,   p‑MEK↑, 1,   mTOR↓, 2,   mTOR↑, 4,   P70S6K↓, 1,   p‑P70S6K↑, 1,   PI3K↓, 3,   PI3K↑, 11,   p‑PI3K↑, 1,   PKA↑, 3,   PKCδ↓, 2,   PKCδ↑, 2,   PP2A↑, 1,   PTEN↓, 2,   PTEN↑, 1,   Raf↓, 1,   STAT3↓, 4,   STAT3↑, 1,   p‑STAT3↑, 1,   STAT4↓, 1,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF2↑, 1,   p‑cJun↓, 1,   p‑cMyc↑, 1,   FOXO1↝, 1,   FOXO3↑, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HDAC↓, 1,   HDAC2↓, 1,   HOTAIR↑, 1,   other↓, 3,   other↑, 2,   other↝, 8,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 1,   PARP∅, 1,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK5↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↑, 1,   neuroG↑, 1,   STAT1↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 2,   ARG1/2↑, 1,   Ca+2↓, 4,   Ca+2↝, 1,   p‑Cofilin↓, 1,   COL1↓, 2,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP3↓, 1,   MMP9↓, 4,   N-cadherin↑, 1,   p‑Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 1,   p‑Smad1↑, 1,   SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD5↑, 1,   p‑T-cadherin↓, 1,   TGF-β1↓, 2,   TGF-β1↑, 1,   TIMP1↓, 1,   TregCell↑, 1,   Vim↓, 1,   α-SMA↓, 5,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   CD31/PECAM-1↓, 1,   CD31/PECAM-1↑, 1,   E-sel↓, 1,   eNOS↑, 2,   HIF-1↓, 1,   NO↓, 9,   NO↑, 2,   VCAM-1↓, 8,   VEGF↓, 1,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↑, 11,   BBB↝, 2,   CLDN4↑, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT4↑, 3,   H+/K+-ATPase↓, 1,   IBI↑, 2,   MMP↑, 8,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 1,   OCLN↑, 2,   OCLN↝, 1,   TJ↑, 3,   TRPM7↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CCL11↓, 1,   CD25+↓, 1,   CD69↓, 1,   COX1↓, 3,   COX2/PTGS2↓, 20,   COX2/PTGS2↑, 1,   CTLA-4↓, 1,   Eos↓, 1,   HMGB1↓, 2,   ICAM-1↓, 4,   IFN-γ↓, 3,   IL1↓, 2,   IL10↓, 2,   IL10↑, 2,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 20,   IL2↓, 2,   IL2↑, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 1,   IL6?, 1,   IL6↓, 22,   IL8↓, 3,   Imm↑, 7,   Imm⇅, 1,   Inflam↓, 78,   pol-M2 MC↑, 1,   Macrophages↓, 1,   MCP1/CCL2↓, 2,   MyD88↓, 1,   Neut↓, 1,   NF-kB↓, 41,   p‑NF-kB↓, 3,   NLRP3↓, 4,   p‑p50↓, 1,   p65↓, 1,   p‑p65↓, 2,   PGE2↓, 5,   PGE2↑, 1,   RAGE↓, 2,   Th1 response↓, 2,   Th17↓, 1,   Th2↑, 2,   TLR2↓, 1,   TLR4↓, 7,   TNF-α↓, 27,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 11,   ADAM10↑, 1,   BChE↓, 3,   BDNF↑, 12,   BDNF∅, 1,   GABA↑, 1,   NGF↑, 1,   PSD95↑, 1,   TPH1↓, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 4,   Aβ↓, 16,   Aβ↑, 1,   BACE/β-secretase↓, 3,   IDE↑, 1,   tau↓, 3,   p‑tau↓, 4,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   ERβ/ESR2↑, 1,   Estro↓, 1,   GLP-1R↑, 1,   NR1H4↑, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 16,   BioAv↑, 27,   BioAv↝, 18,   BioEnh↑, 3,   Dose?, 1,   Dose↑, 1,   Dose↝, 7,   eff↓, 2,   eff↑, 9,   GSTA1↑, 2,   Half-Life↓, 1,   Half-Life↑, 2,   Half-Life↝, 6,   P-gp/ABCB1↓, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 2,   AST↓, 8,   BloodF↑, 1,   BMD↑, 2,   BP↓, 4,   BP↝, 1,   creat↓, 2,   CRP↓, 2,   EGFR↓, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 22,   IRes↝, 1,   LDH↓, 3,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 2,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 1,   antiAll↑, 9,   AntiArt↑, 4,   AntiCan↑, 12,   AntiDiabetic↓, 1,   AntiDiabetic↑, 15,   antiPs↑, 1,   AntiTum↑, 3,   cardioP↑, 20,   CardioT↓, 1,   chemoP↑, 5,   chemoPv↑, 3,   cognitive↓, 1,   cognitive↑, 21,   diuretic↑, 2,   hepatoP↓, 1,   hepatoP↑, 20,   Learn↑, 1,   memory↑, 19,   motorD↑, 3,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 55,   Obesity↓, 6,   Pain↓, 3,   radioP↑, 1,   RenoP↑, 8,   Strength↑, 1,   Stroke↓, 3,   toxicity↓, 12,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 3,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiP↑, 1,   AntiViral↑, 8,   Bacteria↓, 13,   Diar↓, 1,   GutMicro↑, 9,   Inf↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 436

Scientific Paper Hit Count for: ERK, ERK signaling
16 Berberine
16 Curcumin
15 Fisetin
15 Quercetin
13 Sulforaphane (mainly Broccoli)
12 Silymarin (Milk Thistle) silibinin
11 Shikonin
10 EGCG (Epigallocatechin Gallate)
10 Magnetic Fields
9 Apigenin (mainly Parsley)
9 Kaempferol
9 Thymoquinone
8 Luteolin
8 Baicalein
7 Artemisinin
7 Caffeic acid
7 Formononetin
6 Radiotherapy/Radiation
6 Propolis -bee glue
6 Honokiol
6 Isobavachalcone
6 Morin
6 Licochalcone A
6 Lycopene
5 Alpha-Lipoic-Acid
5 Chrysin
5 Piperine
5 Resveratrol
4 Silver-NanoParticles
4 Allicin (mainly Garlic)
4 Astaxanthin
4 Carvacrol
4 Emodin
4 Fucoidan
4 Garcinol
4 phytic acid, Inositol hexakisphosphate
4 isoorientin
4 Magnolol
4 Matrine
4 Rosmarinic acid
4 Vitamin K2
3 Cisplatin
3 Berbamine
3 Boswellia (frankincense)
3 Chlorogenic acid
3 Cynaropicrin
3 Paclitaxel/Taxol
3 Ferulic acid
3 Hyperoside
3 Inositol
3 methylseleninic acid
3 Phenethyl isothiocyanate
3 Piperlongumine
3 Ursolic acid
3 Vitamin C (Ascorbic Acid)
2 Andrographis
2 Ashwagandha(Withaferin A)
2 beta-glucans
2 Beta-Caryophyllene
2 Betulinic acid
2 Bromelain
2 Boron
2 Zinc
2 Capsaicin
2 Thymol-Thymus vulgaris
2 chaetocin
2 Crocetin
2 Cucurbitacin
2 Deguelin
2 Dandelion Root
2 Flaxseed/Linseed
2 5-fluorouracil
2 Gambogic Acid
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Ginkgetin
2 isoquercitrin
2 Licorice
2 Lutein
2 Magnetic Field Rotating
2 Myricetin
2 Nimbolide
2 Phenylbutyrate
2 Pterostilbene
2 Sanguinarine
2 Salvia miltiorrhiza
2 Urolithin
2 Vitexin
1 1,8-Cineole
1 Camptothecin
1 alpha Linolenic acid
1 Anethole/trans-Anethole
1 Ascorbyl Palmitate
1 Trastuzumab
1 Baicalin
1 Biochanin A
1 Bacopa monnieri
1 brusatol
1 α-Bisabolol / Chamomile oil
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorophyllin
1 Cinnamon
1 Citric Acid
1 Coenzyme Q10
1 Vitamin E
1 Copper and Cu NanoParticles
1 Dihydrocaffeic Acid
1 Photodynamic Therapy
1 Bicalutamide
1 gefitinib, erlotinib
1 Docosahexaenoic Acid
1 Dipyridamole
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 eicosapentaenoic acid
1 Evodiamine
1 flavonoids
1 Metformin
1 Gallic acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Ginseng
1 Graviola
1 Grapeseed extract
1 Hydrogen Gas
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Huperzine A/Huperzia serrata
1 Isoliquiritigenin
1 Juglone
1 Mung Bean Sprouts
1 Lasiodin
1 Lemongrass Extract/Citral
1 SDG/lignans
1 Linalool
1 mebendazole
1 Methyl Jasmonate
1 vp16, etoposide
1 Methyl salicylate / Sweet Birch oil
1 Magnesium
1 Melatonin
1 Moringa oleifera
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Naringin
1 Niclosamide (Niclocide)
1 Oleocanthal
1 Oxygen, Hyperbaric
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Plumbagin
1 Salvia officinalis
1 Aromatherapy
1 Aflavin-3,3′-digallate
1 Tomatine
1 Turmerones
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:105  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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