RadioS Cancer Research Results

RadioS, RadioSensitizer: Click to Expand ⟱

Source:

Type:

A radiosensitizer is an agent that makes cancer cells more sensitive to the damaging effects of radiation therapy. By using a radiosensitizer, clinicians aim to enhance the effectiveness of radiation treatment by either increasing the damage incurred by tumor cells or by interfering with the cancer cells’ repair mechanisms. This can potentially allow for lower doses of radiation, reduced side effects, or improved treatment outcomes.
Pathways that help Radiosensitivity: downregulating HIF-1α, increase SIRT1, Txr

List of Natural Products with radiosensitizing properties:
-Curcumin:modulate NF-κB, STAT3 and has been shown in preclinical studies to enhance the effects of radiation by inhibiting cell survival pathways.
-Resveratrol:
-EGCG:
-Quercetin:
-Genistein:
-Parthenolide:

How radiosensitizers inhibit the thioredoxin (Trx) system in cellular contexts. Notable radiosensitizers, including:
-gold nanoparticles (GNPs),
-gold triethylphosphine cyanide ([Au(SCN) (PEt3)]),
-auranofin, ceria nanoparticles (CONPs),
-curcumin and its derivatives,
-piperlongamide,
-indolequinone derivatives,
-micheliolide,
-motexafin gadolinium, and
-ethane selenide selenidazole derivatives (SeDs)

Scientific Papers found: Click to Expand⟱

4750-

SSE,

Rad,

Selenium in Radiation Oncology—15 Years of Experiences in Germany

-

Review,

Var,

NA

RadioS∅, radioP↑, eff↑,

5079-

SSE,

Rad,

The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues

-

in-vitro,

Lung,

A549

-

in-vitro,

Nor,

BEAS-2B

chemoP↑, eff↝, ROS↑, MMP↓, Cyt‑c↑, TumCG↓, RadioS↝, other↝,

5078-

SSE,

Rad,

Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer

-

Trial,

Pca,

NA

33 mg dose level,

15 patients with metastatic cancer treated with selenite (5.5 to 49.5 mg) orally as a single dose 2 hours before each radiation therapy (RT) treatment.

Half-Life↝, OS↑, Pain↓, PSA↓, GSH↓, ROS↑, selectivity↑, TumCG↓, AR↓, Dose↑, ChemoSen↑, RadioS↑,

2127-

TQ,

Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways

-

Review,

GBM,

NA

chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2/PTGS2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, Synergy↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,

2084-

TQ,

Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

-

Review,

Var,

NA

*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2/BIRC3↑, XIAP↓, TNF-α↓, COX2/PTGS2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, CompStab↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,

2090-

TQ,

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies

-

Review,

Var,

NA

AntiCan↑, ChemoSen↑, RadioS↑, chemoP↑, *radioP↑,

2106-

TQ,

Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

-

Review,

Var,

NA

Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,

3422-

TQ,

Thymoquinone, as a Novel Therapeutic Candidate of Cancers

-

Review,

Var,

NA

selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, CompStab↝, Synergy↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, Synergy↑, EMT↓, ROS↑, DNMT1↓, Synergy↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *Synergy↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,

4833-

Uro,

Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine

-

Review,

Var,

NA

392 to 566 µM across various breast cancer cell lines

-

Review,

AD,

NA

-

Review,

IBD,

NA

BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,

6894-

VitC,

Rad,

Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue

-

Review,

Var,

NA

AntiTum↑, selectivity↑, H2O2↑, RadioS↑, radioP↑, ChemoSen↑, ROS↑, DNAdam↑,

1740-

VitD3,

Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms

-

Review,

Var,

NA

Risk↓, eff↑, eff↑, Risk↓, Risk↓, ChemoSen↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp9↑, hTERT/TERT↓, Synergy↑, E-cadherin↑, CLDN2↑, ZO-1↑, Snail↓, Zeb1↓, Vim↓, VEGF↓, NK cell↑, Risk↓, eff↑,

4618-

VitD3,

Vitamin D sensitizes cervical cancer to radiation-induced apoptosis by inhibiting autophagy through degradation of Ambra1

-

in-vivo,

Cerv,

NA

Risk↓, RadioS↑, Apoptosis↑, EMT↝,

1824-

VitK2,

Vitamin K and its analogs: Potential avenues for prostate cancer management

-

Review,

Pca,

NA

AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, Synergy↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,

4887-

ZER,

Rad,

Cisplatin,

Zerumbone acts as a radiosensitizer in head and neck squamous cell carcinoma

-

in-vitro,

HNSCC,

CAL27

Apoptosis↑, ChemoSen↑, RadioS↑, tumCV↓,

Showing Research Papers: 301 to 314 of 314
Prev Page 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 314

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2, antiOx↑, 10, Catalase↓, 6, Catalase↑, 1, Catalase∅, 1, cystine↓, 1, Fenton↑, 4, GPx↓, 2, GPx↑, 2, GPx1↓, 1, GPx4↓, 4, GSH↓, 25, GSH↑, 2, GSH/GSSG↓, 1, GSR↓, 1, GSTs↓, 2, GSTs↝, 1, GSTs∅, 1, H2O2↓, 2, H2O2↑, 4, HO-1↓, 9, HO-1↑, 4, HO-2↓, 1, Iron↓, 1, Iron↑, 2, i-Iron↑, 1, ox-Keap1↓, 1, rd-Keap1↑, 1, lipid-P↓, 3, lipid-P↑, 9, MDA↓, 1, MDA↑, 2, NOX4↑, 1, NQO1↓, 2, NQO1↑, 2, NRF2↓, 14, NRF2↑, 11, NRF2∅, 1, Prx↓, 1, Prx4↑, 1, PYCR1↓, 1, ROS?, 1, ROS↓, 12, ROS↑, 163, ROS⇅, 5, ROS↝, 1, mt-ROS↑, 3, RPM↑, 1, SOD↓, 7, SOD↑, 4, SOD1↑, 1, SOD2↓, 5, SOD2↑, 1, TBARS↑, 1, Thiols↓, 1, Trx↓, 3, TrxR↓, 12, TrxR1↓, 1, VitC↓, 1, VitE↓, 1, xCT/SLC7A11↓, 4,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2, Tf↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1, CDC2↓, 2, CDC25↓, 1, compI↓, 2, EGF↓, 2, ETC↓, 1, ETC↑, 1, Insulin↓, 4, mitResp↓, 2, mitResp↑, 1, mtDam↑, 7, OCR↓, 4, OCR↑, 3, mt-OCR↓, 1, OXPHOS↓, 3, OXPHOS↑, 6, p‑PDH↓, 1, SIRT3↓, 1, SIRT3↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2, 5LO↓, 2, ACLY↓, 1, ACSL4↑, 1, ALAT↓, 3, ALAT↑, 1, ALDOA↓, 1, AMP↑, 1, AMPK↑, 16, ATP↓, 10, CAIX/CA9↓, 1, CAIX/CA9↑, 1, CRM↑, 1, ECAR↓, 2, ECAR↝, 1, ENO1↓, 1, FASN↓, 2, GAPDH↓, 1, glucoNG↓, 1, glucose↓, 2, GlucoseCon↓, 5, GlutMet↓, 1, Glycolysis↓, 26, Glycolysis↝, 1, Glycolysis∅, 1, GSK‐3β↓, 3, GSK‐3β↑, 2, p‑GSK‐3β↓, 1, H2S↑, 1, HK2↓, 11, HMG-CoA↓, 2, lactateProd↓, 9, LDHA↓, 4, LDL↓, 1, lipoGen↓, 1, MCT4↓, 2, MethCyc↓, 1, NAD↓, 1, NADH:NAD↓, 1, NADPH↓, 1, NADPH↑, 2, O-Glc↓, 1, PDK1 / PDPK1?, 2, PDK1 / PDPK1↓, 4, PDKs↓, 1, PDKs↑, 1, PFK↓, 4, PKM2↓, 9, polyA↓, 1, PPP↓, 1, PPP↑, 1, Pyruv↓, 2, SIRT1↓, 4, SIRT1↑, 5, SIRT2↓, 1, TCA↓, 1, TCA↑, 1, TS↓, 2, Warburg↓, 5,

Cell Death(tgid=5) ⓘ

AIF↑, 5, APAF1↑, 1, Apoptosis?, 1, Apoptosis↓, 3, Apoptosis↑, 102, ASC↓, 1, BAD↓, 1, BAD↑, 3, Bak↓, 1, Bak↑, 3, BAX↓, 3, BAX↑, 34, Bax:Bcl2↑, 11, Bcl-2↓, 41, Bcl-2↑, 1, Bcl-xL↓, 8, BID↓, 1, BID↑, 2, BIM↑, 2, BNIP3↑, 1, BNIP3↝, 1, Casp↑, 17, cl‑Casp↑, 1, Casp1↓, 1, Casp1↑, 1, Casp12?, 1, Casp3↓, 2, Casp3↑, 45, cl‑Casp3↑, 10, proCasp3↑, 1, pro‑Casp3↑, 1, Casp6↑, 1, Casp7↑, 5, Casp8↑, 11, cl‑Casp8↑, 4, Casp9↓, 1, Casp9↑, 29, cl‑Casp9↑, 5, cFLIP↓, 1, Cupro↑, 1, Cyt‑c↓, 1, Cyt‑c↑, 36, Diablo↑, 3, DR5↑, 7, Fas↑, 7, FasL↓, 1, FasL↑, 4, Ferroptosis↑, 8, GSDME↑, 1, IAP1↓, 3, IAP2/BIRC3↑, 1, iNOS↓, 4, iNOS↑, 1, Mcl-1↓, 8, MDM2↓, 5, p‑MDM2↓, 1, MOMP↑, 3, Necroptosis↑, 1, NOXA↑, 2, p38↑, 5, p‑p38↓, 1, p‑p38↑, 3, Paraptosis↑, 1, PUMA↑, 4, Pyro↑, 1, RIP1↑, 1, RIP3↑, 1, survivin↓, 15, TRAIL↑, 3, TRAIL⇅, 1, TRAILR↑, 1, TumCD↓, 1, TumCD↑, 12, XIAP↓, 9, YAP/TEAD↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 50, Akt↑, 2, p‑Akt↓, 13, AMPKα↑, 1, BRAF↓, 1, p‑CaMKII ↓, 1, CK2↓, 2, cMET↓, 1, cSrc↓, 2, DYRK1B↓, 1, EF-1α↓, 1, EGFR↓, 14, EGFR↑, 2, ERK↓, 20, ERK↑, 3, p‑ERK↓, 4, FGFR1↓, 3, FGFR2↓, 1, FOXD3↑, 2, HCAR2↑, 1, HER2/EBBR2↓, 1, p‑HER2/EBBR2↓, 1, HGF/c-Met↓, 1, IGF-1R↓, 2, IKKα↓, 2, IκB↓, 2, IκB↑, 1, JAK↓, 1, JAK↝, 1, JAK1↓, 4, JAK2↓, 8, JNK↓, 2, JNK↑, 12, p‑JNK↑, 2, MAPK↓, 16, MAPK↑, 6, MEK↓, 3, mTOR↓, 36, mTOR↑, 1, mTORC2↓, 2, p70S6↓, 1, P70S6K↓, 1, P90RSK↓, 2, PAK↓, 1, PI3K↓, 38, PI3K↑, 2, p‑PI3K↓, 2, PI3K/mTOR/ETS2↓, 1, PIK3CA↓, 1, PKCδ↓, 1, PP2A↑, 1, PTEN↓, 1, PTEN↑, 13, Raf↓, 3, RAS↓, 6, p‑S6K↓, 1, SHP1↑, 1, Sp1/3/4↓, 7, Src↓, 1, p‑Src↓, 1, STAT↓, 1, STAT3↓, 27, STAT3↑, 1, p‑STAT3↓, 9, STAT6↓, 2, p‑STAT6↓, 1, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 6, ATF4↝, 1, cJun↓, 5, cMyc↓, 15, cMyc↑, 1, p‑cMyc↑, 1, DNMT1↓, 5, DNMT3A↓, 1, DNMTs↓, 2, EZH2↓, 1, FOXO↑, 2, FOXO1↑, 1, FOXO3↓, 2, FOXO3↑, 1, p‑FOXO3↓, 3, FOXO4↓, 1, FOXO4↑, 1, H3↓, 2, H4↓, 1, HDAC↓, 9, HDAC1↓, 1, HDAC2↓, 2, HDAC3↓, 2, HDAC8↓, 1, miR-143↑, 1, miR-21↓, 1, miR-30a-5p↑, 1, miR-34a↑, 2, miR-375↑, 1, Myc↓, 4, Myc↑, 1, n-MYC↓, 2, OCT4↓, 2, other↓, 1, other↑, 5, other↝, 8, PhotoS↑, 5, Prot↓, 1, sonoS↑, 2, SOX2↓, 4, SOX4↑, 1, TCF-4↓, 2, tumCV↓, 17, tumCV↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 6, eIF2α↑, 2, p‑eIF2α↑, 3, ER Stress↑, 25, GRP78/BiP↓, 1, GRP78/BiP↑, 6, HSF1↓, 1, HSP27↓, 2, HSP70/HSPA5↓, 2, HSP70/HSPA5↑, 3, HSP72↑, 1, HSP90↓, 8, HSPs↑, 2, IRE1↑, 3, PERK↑, 4, Proteasome?, 1, SERPINH1/HSP47↓, 1, UPR↑, 5, XBP-1↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2, ATG7↑, 1, Beclin-1/ATG6↓, 2, Beclin-1/ATG6↑, 4, CTSB↓, 1, CTSD↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3B-II↑, 1, LC3I↑, 1, LC3II↓, 1, LC3II↑, 3, LC3s↓, 1, lysoMP↑, 1, p62↓, 2, p62↑, 2, TumAuto↓, 2, TumAuto↑, 21, TumAuto↝, 2, mt-TumAuto↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

APE1/APEX1↓, 1, BRCA1↓, 1, BRCA1↑, 1, BRCA2↓, 5, BRCA2↑, 1, DFF45↓, 1, DFF45↑, 1, DNAdam↓, 4, DNAdam↑, 51, DNArepair↓, 8, DNArepair↑, 1, hTERT/TERT↓, 8, P53↓, 1, P53↑, 35, P53↝, 1, p‑P53↑, 1, PARP↓, 1, PARP↑, 8, cl‑PARP↑, 21, PCNA↓, 5, POLD1↓, 1, SIRT6↑, 1, Telomerase↓, 11, TOP1↓, 6, TOP2↓, 4, TP53↓, 1, TP53↑, 1, γH2AX↑, 8, γH2AX↝, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5, CDK1↑, 2, p‑CDK1↓, 1, CDK2↓, 14, CDK2↑, 1, CDK4↓, 16, CDK4↑, 1, CDK6↓, 12, CDK6↑, 1, CDK8↓, 2, Cyc↓, 2, cycA1/CCNA1↓, 3, CycB/CCNB1↓, 10, CycB/CCNB1↑, 2, cycD1/CCND1↓, 26, cycE/CCNE↓, 9, E2Fs↓, 2, GADD45A↑, 1, Ki-67↓, 11, mitA↑, 4, P21↓, 2, P21↑, 26, p27/CDKN1B↑, 14, RB1↓, 1, p‑RB1↓, 4, Securin↓, 2, TubPol↓, 1, TumCCA↓, 4, TumCCA↑, 82,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3, ALDH1A1↓, 1, CD133↓, 2, CD34↓, 1, cFos↓, 5, cFos↑, 1, cMYB↓, 1, CSCs?, 1, CSCs↓, 28, CSCsMark↓, 1, Diff↓, 1, Diff↑, 5, EIF4E↓, 1, FGF↓, 2, Gli1↓, 3, HH↓, 5, HMGCR↓, 2, IGF-1↓, 5, IGF-1↑, 1, Ki-67↓, 11, Let-7↑, 1, LRP6↓, 1, mTORC1↓, 7, p‑mTORC1↓, 1, Nanog↓, 3, Nestin↓, 2, NICD↓, 1, NOTCH↓, 9, NOTCH1↓, 3, NOTCH1↑, 2, NOTCH3↓, 1, PTCH1↓, 1, PTCH2↓, 1, Shh↓, 6, Smo↓, 1, STAT1↓, 1, TAZ↓, 1, TumCG↓, 46, TumCG↑, 2, TumCP?, 1, TumCP↓, 61, TumCP↑, 1, tyrosinase↓, 1, Wnt↓, 19, Wnt/(β-catenin)↓, 3,

Migration(tgid=13) ⓘ

AEG1↓, 1, AntiAg↑, 1, AP-1↓, 4, AXL↓, 1, Ca+2↓, 1, Ca+2↑, 16, Ca+2↝, 1, i-Ca+2↑, 1, Cav1↓, 1, Cdc42↓, 1, E-cadherin↓, 5, E-cadherin↑, 16, EMT↓, 37, EMT↝, 1, FAK↓, 3, p‑FAK↓, 1, Fibronectin↓, 1, Furin↓, 1, IQGAP3↓, 1, ITGB1↓, 1, ITGB3↓, 1, KRAS↓, 1, MALAT1↓, 4, MET↓, 1, p‑MET↓, 1, MMP1↓, 3, MMP13↓, 2, MMP2↓, 32, MMP7↓, 5, MMP9↓, 33, MMP9↑, 1, MMPs↓, 8, MUC4↓, 1, N-cadherin↓, 10, NEDD9↓, 1, PAK1↓, 1, PDGF↓, 1, Rac1↓, 3, Rho↓, 2, ROCK1↓, 1, Slug↓, 4, Smad1↑, 1, SMAD2↓, 1, SMAD3↓, 3, Snail↓, 8, TET1↑, 2, TGF-β↓, 8, TGF-β↑, 1, TIMP1↓, 1, TIMP1↑, 3, TIMP2↑, 2, TumCA↓, 1, TumCI↓, 33, TumCMig↓, 27, TumCMig↑, 1, TumMeta?, 1, TumMeta↓, 27, TumMeta↑, 1, Twist↓, 9, Tyro3↓, 1, uPA↓, 6, Vim?, 1, Vim↓, 13, Vim↑, 1, Zeb1↓, 4, ZEB2↓, 1, α-tubulin↓, 2, β-catenin/ZEB1↓, 26,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 48, angioG↑, 1, CD31/PECAM-1↓, 2, Endoglin↑, 1, eNOS↑, 1, HIF-1↓, 3, Hif1a↓, 32, Hif1a↑, 1, Hypoxia↓, 7, LOX1↓, 1, NO↓, 1, NO↑, 3, NO↝, 1, PHDs↓, 1, TXA2↓, 1, VCAM-1↓, 3, VEGF↓, 46, VEGFR2/KDR/Flk1↓, 7,

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1, BBB↑, 6, CellMemb↑, 2, CLDN1↓, 1, CLDN2↓, 1, CLDN2↑, 1, EPR↑, 5, EPR↝, 1, GLUT1↓, 4, GLUT1↑, 1, GLUT2↓, 1, GLUT3↓, 1, GLUT3↑, 1, GLUT4↓, 2, MMP↓, 41, MMP↑, 2, MPT↑, 3, NHE1↓, 1, TRPM7↓, 1, TRPV1↓, 1, TRPV1↝, 1, ZO-1↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1, CCR7↓, 1, CD4+↑, 1, CD44↓, 7, CD8+↑, 1, p‑cDC2↓, 1, COX1↓, 4, COX2/PTGS2↓, 39, COX2/PTGS2↑, 3, CXCR4↓, 5, DCells↑, 1, DR4↑, 1, FOXP3↓, 2, FOXP3↑, 1, Gal-3↓, 1, HCAR2↑, 1, HLA↑, 1, ICAM-1↓, 3, IFN-γ↓, 2, IFN-γ↑, 1, Igs↑, 1, IL1↑, 1, IL10↓, 3, IL10↑, 1, IL12↓, 1, IL1β↓, 10, IL2↓, 2, IL2↑, 2, IL4↓, 2, IL6↓, 17, IL8↓, 4, IL8↑, 1, Imm↑, 19, Inflam↓, 21, M2 MC↓, 1, MCP1/CCL2↓, 2, NF-kB↓, 74, NF-kB↑, 5, p‑NF-kB↓, 3, p‑NF-kB↑, 1, NK cell↑, 4, NLRP3↓, 3, p65↓, 4, p65↑, 1, p‑p65↓, 2, PD-1↓, 3, PD-1↝, 1, PD-L1↓, 6, PD-L1↑, 1, PGE2↓, 10, PSA↓, 2, RANTES↓, 1, SOCS-3↑, 1, T-Cell↑, 2, TCF↓, 2, Th1 response↑, 2, TLR4↓, 2, TNF-α↓, 10, TNF-α↑, 2, Treg lymp↓, 1,

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2, pH↝, 3, e-pH↓, 1, e-pH↑, 1, i-pH↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1, AKR1C3/17β-HSD5/PGF Synthase↓, 1, AR↓, 7, ER-α36↓, 2, ER(estro)↓, 1, Estro↝, 1, PPARγ↓, 1, PPARγ↑, 2, RANKL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 31, BioAv↑, 30, BioAv↝, 8, BioEnh↑, 1, CBR1↓, 1, chemoR↓, 2, ChemoSen?, 1, ChemoSen↓, 5, ChemoSen↑, 153, ChemoSen⇅, 1, ChemoSen∅, 2, CompStab?, 1, CompStab↓, 3, CompStab↑, 4, CompStab↝, 2, CYP1A1↓, 1, CYP3A4↓, 1, Dose?, 4, Dose↓, 2, Dose↑, 9, Dose↝, 36, Dose∅, 8, eff↓, 27, eff↑, 85, eff⇅, 1, eff↝, 10, GSTZ1↓, 1, GSTZ1↝, 1, Half-Life↓, 9, Half-Life↑, 3, Half-Life↝, 8, MDR1↓, 7, MRP1/ABCC1↓, 3, P-gp/ABCB1↓, 9, P450↓, 1, P450↝, 1, RadioS?, 3, RadioS↓, 6, RadioS↑, 304, RadioS↝, 2, RadioS∅, 2, selectivity?, 1, selectivity↓, 1, selectivity↑, 64, Synergy↑, 72, Synergy↝, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3, ALAT↑, 1, ALP↓, 1, AR↓, 7, AST↓, 2, AST↑, 1, BG↓, 2, BloodF↑, 4, BRAF↓, 1, BRCA1↓, 1, BRCA1↑, 1, CEA↓, 3, CRP↓, 1, EGFR↓, 14, EGFR↑, 2, EZH2↓, 1, Ferritin↓, 2, HER2/EBBR2↓, 1, p‑HER2/EBBR2↓, 1, hTERT/TERT↓, 8, IL6↓, 17, KRAS↓, 1, LDH↓, 5, LDH↑, 1, LDH↝, 1, Myc↓, 4, Myc↑, 1, NSE↓, 1, PD-L1↓, 6, PD-L1↑, 1, PSA↓, 2, TP53↓, 1, TP53↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2, AntiCan↓, 1, AntiCan↑, 23, antiNeop↑, 1, AntiTum↑, 13, cachexia↓, 1, cardioP↑, 5, CardioT↓, 2, chemoP↑, 20, chemoPv↑, 7, ChemoSideEff↓, 6, CR↑, 1, fatigue↓, 2, hepatoP↑, 3, hepatoP↝, 1, LC↑, 1, Mucositis↓, 1, neuroP↑, 3, NP/CIPN↓, 1, NP/CIPN↑, 1, OS↑, 20, OS∅, 2, Pain↓, 3, PFS↓, 1, PFS∅, 1, QoL↑, 5, QoL∅, 1, radioP↑, 17, Remission↑, 1, RenoP↑, 1, Risk↓, 13, Risk↑, 1, Risk∅, 1, Sleep↑, 1, toxicity↓, 23, toxicity↑, 3, toxicity⇅, 1, toxicity↝, 10, toxicity∅, 5, TumVol↓, 8, TumW↓, 6,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1, GutMicro↑, 2, GutMicro↝, 2, Sepsis↓, 1,
Total Targets: 777

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1, antiOx↓, 3, antiOx↑, 22, Catalase↑, 12, GPx↑, 10, GPx1↑, 1, GPx4↑, 1, GSH↓, 1, GSH↑, 17, GSH/GSSG↑, 1, GSTs↑, 1, H2O2↓, 1, H2O2↑, 1, HO-1↑, 5, Keap1↓, 1, Keap1↑, 1, ox-Keap1↑, 1, lipid-P↓, 9, MDA↓, 6, MDA↑, 1, NRF2↓, 1, NRF2↑, 12, ROS?, 1, ROS↓, 34, ROS↑, 2, ROS↝, 1, ROS∅, 2, SOD↓, 1, SOD↑, 13, SOD1↑, 1, SOD2↑, 1, TAC↑, 1, TBARS↓, 1, uricA↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1, OCR↑, 1, OXPHOS↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1, AMPK↑, 3, ATP↑, 2, glucose↓, 1, GlucoseCon↑, 1, LDL↓, 1, lipidLev↓, 1, NAD↑, 1, NADPH↑, 1, NADPH∅, 1, SIRT1↑, 3,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3, BAX↓, 1, Bcl-2↑, 1, Casp3↓, 3, Casp9↓, 1, Cyt‑c↓, 2, iNOS↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3, p‑CREB↑, 1, ERK↓, 2, ERK↑, 2, JNK↓, 1, MAPK↓, 1, PI3K↓, 2, STAT3↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

p‑cMyc↑, 1, other↑, 4, other↝, 3,

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1, HSPs↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1, p300↓, 1, Wnt↑, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 1, Ca+2↑, 1, Cartilage↑, 1, FAK↑, 1, MMP13↓, 1, MMP9↓, 1, ROCK1↓, 1, TGF-β↓, 1, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2, HIF-1↓, 1, NO↓, 1, VEGF↑, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2, BBB↝, 1, GastroP↑, 1, MMP↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1, CD8+↑, 1, COX1↓, 1, COX2/PTGS2↓, 5, CXCR4↓, 1, IL10↑, 3, IL17↓, 2, IL18↓, 2, IL1β↓, 6, IL2↓, 1, IL6↓, 7, IL6↑, 1, IL8↓, 1, Imm↑, 2, Inflam↓, 28, NF-kB↓, 3, NLRP3↑, 1, PGE2↓, 1, TNF-α↓, 12,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2, BChE↓, 1, BDNF↑, 1, GABA↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 3, BACE/β-secretase↓, 2,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1, GR↑, 1, p‑PPARγ↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1, BioAv↓, 13, BioAv↑, 10, BioAv↝, 4, BioEnh↑, 1, Dose↑, 1, Dose⇅, 1, Dose↝, 7, eff↑, 4, eff↝, 1, GSTA1↓, 1, Half-Life↓, 2, Half-Life↝, 4, Half-Life∅, 1, RadioS↑, 1, Synergy↑, 2,

Clinical Biomarkers(tgid=22) ⓘ

ALP↓, 1, AST↓, 1, creat↓, 1, CRP↓, 3, IL6↓, 7, IL6↑, 1, LDH↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, AntiArt↑, 1, AntiCan↑, 1, AntiDiabetic↑, 6, AntiTum↓, 1, cardioP↑, 13, CardioT↓, 1, chemoP↑, 3, chemoPv↑, 6, cognitive↑, 4, hepatoP↑, 8, memory↑, 4, motorD↑, 2, neuroP↑, 18, Obesity↓, 2, Pain↓, 2, radioP↑, 8, RenoP↑, 3, Risk↓, 1, Stroke↓, 1, toxicity?, 1, toxicity↓, 15, toxicity↑, 2, toxicity↝, 5, toxicity∅, 5, Wound Healing↑, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2, AntiFungal↑, 1, AntiViral↑, 1, Bacteria↓, 7, Diar↓, 1, GutMicro↑, 3, Inf↓, 1,
Total Targets: 175

Scientific Paper Hit Count for: RadioS, RadioSensitizer

93 Radiotherapy/Radiation
19 Curcumin
18 Hyperthermia
11 Silver-NanoParticles
9 Fisetin
8 Betulinic acid
8 Propolis -bee glue
8 Resveratrol
7 Baicalein
7 Magnetic Fields
6 Chemotherapy
6 Cisplatin
6 Berberine
6 salinomycin
6 diet Methionine-Restricted Diet
6 Ellagic acid
5 Copper and Cu NanoParticles
5 Dichloroacetate
5 Disulfiram
5 Gold NanoParticles
5 mebendazole
5 Melatonin
5 Thymoquinone
4 Atorvastatin
4 Chrysin
4 Honokiol
4 Oxygen, Hyperbaric
4 Luteolin
4 Phenylbutyrate
4 Sulforaphane (mainly Broccoli)
4 Selenium NanoParticles
4 Selenite (Sodium)
3 Selenium
3 Apigenin (mainly Parsley)
3 Ashwagandha(Withaferin A)
3 brusatol
3 Crocetin
3 Eugenol
3 diet FMD Fasting Mimicking Diet
3 Ferulic acid
3 Gambogic Acid
3 Kaempferol
3 Quercetin
3 Metformin
3 Piperlongumine
3 Parthenolide
3 Sulfasalazine
2 3-bromopyruvate
2 Auranofin
2 Allicin (mainly Garlic)
2 Anti-oxidants
2 Vitamin C (Ascorbic Acid)
2 Astaxanthin
2 Beta-Caryophyllene
2 Brucea javanica
2 Caffeic acid
2 Capsaicin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 chemodynamic therapy
2 Celastrol
2 diet Short Term Fasting
2 Diindolylmethane
2 immunotherapy
2 EGCG (Epigallocatechin Gallate)
2 Geldanamycin
2 Gossypol/AT-101
2 Magnolol
2 Methyl Jasmonate
2 methylseleninic acid
2 Niclosamide (Niclocide)
2 Oleuropein
2 Rosmarinic acid
2 Silymarin (Milk Thistle) silibinin
2 Vitamin D3
1 2-DeoxyGlucose
1 Astragalus
1 Alpha-Lipoic-Acid
1 Vitamin A, Retinoic Acid
1 Artemisinin
1 Aspirin
1 Baicalin
1 Berbamine
1 Biochanin A
1 Bromelain
1 borneol
1 Boron
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Zinc
1 Carvacrol
1 Thymol-Thymus vulgaris
1 carboplatin
1 Celecoxib
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Coenzyme Q10
1 Cucurbitacin
1 Diclofenac
1 Electrical Pulses
1 Fenbendazole
1 Formononetin
1 Fucoidan
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Genistein (soy isoflavone)
1 Germanium inorganic
1 Ginkgolide B
1 Ginkgetin
1 Hydroxycinnamic-acid
1 Hyperoside
1 Indole-3-carbinol
1 Isoliquiritigenin
1 isoflavones
1 low dose naltrexone
1 Lycopene
1 Mung Bean Sprouts
1 MCT, metronomic chemo
1 Modified Citrus Pectin
1 Methylglyoxal
1 HydroxyTyrosol
1 Piperine
1 Psoralidin
1 doxorubicin
1 Oxaliplatin
1 Shikonin
1 Urolithin
1 Vitamin K2
1 Zerumbone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1107  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Home Page