selectivity Cancer Research Results

selectivity, selectivity: Click to Expand ⟱
Source:
Type:
The selectivity of cancer products (such as chemotherapeutic agents, targeted therapies, immunotherapies, and novel cancer drugs) refers to their ability to affect cancer cells preferentially over normal, healthy cells. High selectivity is important because it can lead to better patient outcomes by reducing side effects and minimizing damage to normal tissues.

Achieving high selectivity in cancer treatment is crucial for improving patient outcomes. It relies on pinpointing molecular differences between cancerous and normal cells, designing drugs or delivery systems that exploit these differences, and overcoming intrinsic challenges like tumor heterogeneity and resistance

Factors that affect selectivity:
1. Ability of Cancer cells to preferentially absorb a product/drug
-EPR-enhanced permeability and retention of cancer cells
-nanoparticle formations/carriers may target cancer cells over normal cells
-Liposomal formations. Also negatively/positively charged affects absorbtion

2. Product/drug effect may be different for normal vs cancer cells
- hypoxia
- transition metal content levels (iron/copper) change probability of fenton reaction.
- pH levels
- antiOxidant levels and defense levels

3. Bio-availability
Scientific Papers found: Click to Expand⟱
1971- GamB,    Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, MDA-MB-468 - in-vivo, NA, NA
Paraptosis↑, ER Stress↑, MMP↓, eff↓, selectivity↑, p‑ERK↑, p‑JNK↑, eff↓,
7088- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC4
TumCG↓, TumCP↓, Apoptosis↑, TumCCA↑, selectivity↑, NF-kB↓, COX2/PTGS2↓, VEGF↓,
7233- GAs,    Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis
- in-vitro, Laryn, HEp2
TumCG↓, selectivity↑, Casp3↓, Bcl-2↓, BAX↑, Bax:Bcl2↑, TumCP↓,
7226- GBE,    Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells involving MAPK signaling pathways
- vitro+vivo, Lung, NA
TumCP↓, selectivity↑, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, Casp3↑, Fas↑, FasL↑, Dose↝, TumCG↓,
7216- GBE,    Cytotoxic effect of Ginkgo biloba kernel extract on HCT116 and A2058 cancer cell lines
- in-vitro, Melanoma, A2058 - in-vitro, CRC, HCT116
tumCV↓, selectivity↑,
7100- Geld,  Rad,    Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin
- in-vitro, Var, NA
HSP90↓, Akt↓, RadioS↑, selectivity↑,
7095- Geld,    Mechanistic studies on Hsp90 inhibition by ansamycin derivatives
- Study, Var, NA
HSP90↓, selectivity↑,
7103- GEN,    A Comprehensive Review of Genistein's Effects in Preclinical Models of Cervical Cancer
- Review, Cerv, NA
TumCP↓, Apoptosis↑, RadioS↑, ChemoSen↑, *antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, TumCG↓, TumCI↓, TumCCA↑, cl‑PARP↑, selectivity↑, CycB/CCNB1↓, CDK1↓, p‑cDC2↓, p‑ERK↓, p‑p38↑, p‑JNK↑, MMP9↓, TIMP1↑, BioAv↓, BioAv↑, Half-Life↑,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓, *antiAll↑,
7252- Gink,    STEAP2-associated modulation of PI3K/AKT/mTOR signaling contributes to ginkgetin-induced apoptosis in bladder cancer cells
- in-vitro, Bladder, 5637 - in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, J82 - in-vitro, Nor, SV-HUC-1
tumCV↓, selectivity↑, TumCMig↓, EMT↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, STEAP3↓, Bax:Bcl2↑, cl‑Casp3↑,
7282- Gins,    Ginsenoside Rh2 stimulates the production of mitochondrial reactive oxygen species and induces apoptosis of cervical cancer cells by inhibiting mitochondrial electron transfer chain complex
- in-vitro, Cerv, NA
compI↓, compIII↓, ETC↓, ROS↑, Apoptosis↑, tumCV↓, selectivity↑, MMP↓, ATP↓, OXPHOS↓, ECAR↓, Glycolysis↓,
4513- GLA,    Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines
- in-vitro, Liver, HUH7
TumCP↓, ROS↑, Apoptosis↑, HO-1↑, Trx↑, lipid-P↑, eff↓, MMP↓, DNAdam↑, selectivity↑,
4510- GLA,    Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies
- Review, GBM, NA
Apoptosis↑, selectivity↑, eff↓, ROS↑, lipid-P↑, P53↑, radioP↑, chemoP↑,
4509- GLA,    Gamma-linolenic Acid (GLA) sensitizes pancreatic cancer cells to gemcitabine
- in-vitro, PC, PANC1
tumCV↑, selectivity↑, ChemoSen↑,
7308- GoldNP,    Colloidal gold: a novel nanoparticle for targeted cancer therapeutics
- Review, Var, NA
selectivity↑, eff↑,
7305- GoldNP,  Rad,    The use of gold nanoparticles to enhance radiotherapy in mice
- in-vivo, Var, NA
Dose↝, selectivity↑, toxicity↝, RadioS↑,
1904- GoldNP,  AgNPs,    Unveiling the Potential of Innovative Gold(I) and Silver(I) Selenourea Complexes as Anticancer Agents Targeting TrxR and Cellular Redox Homeostasis
- in-vitro, Lung, H157 - in-vitro, BC, MCF7 - in-vitro, Colon, HCT15 - in-vitro, Melanoma, A375
TrxR↓, selectivity↑, eff↑, eff↝, ROS↑, MMP↓, Apoptosis↑, eff↑,
7313- Gos,    Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand
- in-vitro, Lung, H460
selectivity↑, eff↑,
7314- Gos,    The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro
- in-vitro, Melanoma, A375
Dose↝, ROS↑, selectivity↑, Half-Life↓, MMP↓, BioAv↑,
7336- Gra,    In Vitro Evaluation of Annona muricata Leaf Infusion as a Modulator of Antineoplastic Drug-Induced Cytotoxicity in Cancer Cell Lines
- in-vitro, BC, MDA-MB-231
ChemoSen↑, selectivity↑,
7335- Gra,    Effect of Annona muricata (Soursop) on Patients with Cancer: A Systematic Review
- Review, Var, NA
TumCG↓, Casp↑, Inflam↓, toxicity↓, other↑, TumCCA↑, Apoptosis↑, TumAuto↑, ATP↓, AIF↑, MMP↓, MOMP↑, Cyt‑c↑, selectivity↑, hepatoP∅,
2437- Gra,    Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity
- in-vitro, Pca, LNCaP - in-vitro, Pca, 22Rv1 - in-vitro, Pca, PC3 - in-vitro, Nor, PWR-1E
NOX↓, selectivity↑,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
7330- GSE,    Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
- Review, Var, NA
*BioAv↑, *ROS↓, AntiCan↑, selectivity↑, RenoP↑, *hepatoP↑, *DNAdam↓, *Stroke↓, *Bcl-2↑, cMyc↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,
2526- H2,    Influence of hydrogen-occluding-silica on migration and apoptosis in human esophageal cells in vitro
- in-vitro, ESCC, KYSE-510
*ROS↓, selectivity↑, ROS↓,
2523- H2,    Prospects of molecular hydrogen in cancer prevention and treatment
- Review, Var, NA
ROS↓, TumCP↓, TumMeta↓, AntiTum↑, GutMicro↑, Inflam↓, OS↑, radioP↑, selectivity↑, SOD↑, IL1β↑, IL8↑, TNF-α↑, neuroP↑,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, Synergy↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
2512- H2,    Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch
- in-vivo, Asthma, NA
*selectivity↑, *lactateProd↓, *ATP↑, *HK2↓, *PFK↓, *Hif1a↓, *PGC-1α↑, *Glycolysis↓, *OXPHOS↑, *Dose↝, *antiAll↑,
2509- H2,    Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
- in-vitro, Endo, AN3CA - in-vivo, Endo, NA
selectivity↑, mt-ROS↑, ROS↑, TumW↓, GSDMD↑, Pyro↑, Dose↝, eff↓, TumVol↓,
2528- H2,    Local generation of hydrogen for enhanced photothermal therapy
- in-vitro, Var, NA
Synergy↑, ROS↓, selectivity↑, ROS↑, other↝, ROS↑,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2/PTGS2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27/CDKN1B↑, P53↑, VEGF↓, MAPK↓,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7369- HibSad,    Components in aqueous Hibiscus rosa-sinensis flower extract inhibit in vitro melanoma cell growth
- in-vitro, Melanoma, B16-BL6 - in-vitro, Nor, LA25
TumCG↓, selectivity↑, Dose↝, eff↑,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
7363- HibSad,    Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation
- in-vitro, GC, NA
Apoptosis↑, selectivity↑, p‑p38↑, JNK↑, cJun↑, Cyt‑c↑, Fas↑, FasL↑,
7356- HibSad,    Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
AntiCan↑, Apoptosis↑, selectivity↑, ChemoSen↑, ROS↑, MMP↓, eff↑,
7347- Hne,    Study of potent cytotoxic activity of Helleborus cyclophyllus Boiss against a human adenocarcinoma cell line
- in-vitro, Lung, A549
tumCV↓, selectivity↑, pro‑Casp3↓, cl‑PARP1↑,
7343- Hne,    Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer
- in-vitro, Melanoma, A431 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HaCaT - in-vitro, Nor, JB6
*Dose↝, *antiOx↑, selectivity↑, Bcl-2↓, BAD↑, BAX↑,
7340- Hne,    Differential cytotoxic properties of Helleborus niger L. on tumour and immunocompetent cells
- in-vitro, AML, NA
TumCP↓, Apoptosis↑, selectivity↑,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
2875- HNK,    Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, SCC, H226
HDAC↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, ac‑H3↑, ac‑H4↑, selectivity↑, CDK2↓, CDK4↓,
2879- HNK,    Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function
- in-vitro, Lung, H226 - in-vivo, NA, NA
tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,
2865- HNK,    Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
- in-vitro, MB, DAOY - vitro+vivo, NA, NA
BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1/ATG6↑, ATG7↑, p62↑, Synergy↑, ChemoSen↑, *toxicity↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2/PTGS2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
2892- HNK,    Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H460 - in-vitro, Lung, H385 - in-vitro, Nor, BEAS-2B
TumCCA↑, Apoptosis↑, SIRT3↑, Hif1a↓, selectivity↑, p‑mTOR↓, p70S6↓,
2895- HNK,    Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity
- in-vitro, Lung, PC9
eff↑, TumCP↓, mt-ROS↑, Prx3↑, mt-STAT3↓, *toxicity∅, selectivity↑, ChemoSen↑,
7371- HOO,    Phytochemical characterization of peanut oil and its ozonized form to explore biological activities in vitro
- in-vitro, Colon, NA
Dose↝, AntiBio↑, antiOx↑, AntiCan↑, selectivity↑,

Showing Research Papers: 301 to 350 of 677
Prev Page 7 of 14 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 677

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 3,   NA⇅, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 16,   antiOx⇅, 1,   Catalase↓, 8,   Catalase↑, 3,   ENOX2↓, 2,   Fenton↑, 8,   frataxin↑, 1,   GCLC↑, 1,   GPx↓, 2,   GPx↑, 2,   GPx4↓, 6,   GSH?, 1,   GSH↓, 45,   GSH↑, 5,   i-GSH∅, 1,   GSH/GSSG↓, 8,   GSSG↑, 3,   GSTs↝, 1,   H2O2↓, 2,   H2O2↑, 14,   mt-H2O2↑, 1,   HO-1↓, 3,   HO-1↑, 10,   HO-2↓, 1,   Iron↓, 4,   Iron↑, 4,   i-Iron↓, 1,   Keap1↓, 2,   Keap1↑, 2,   Keap1↝, 1,   lipid-P↓, 2,   lipid-P↑, 20,   lipidDe↓, 1,   MDA↓, 3,   MDA↑, 7,   i-MDA↑, 1,   NADH↓, 3,   NADH↑, 1,   mt-NADH↓, 1,   NADHdeh?, 1,   NOX↓, 2,   NOX↑, 1,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 11,   NRF2↑, 13,   NRF2∅, 1,   p‑NRF2↑, 1,   Prx↓, 1,   Prx3↑, 1,   Prx4↓, 1,   Prx4↑, 1,   PrxI↓, 1,   RNS↑, 3,   ROS?, 4,   ROS↓, 22,   ROS↑, 311,   ROS⇅, 10,   ROS↝, 3,   ROS∅, 4,   i-ROS?, 1,   i-ROS↓, 1,   i-ROS↑, 4,   mt-ROS↑, 22,   RPM↑, 1,   SOD↓, 5,   SOD↑, 5,   SOD2↓, 3,   SOD2↑, 1,   Thiols↓, 3,   Trx↓, 4,   Trx↑, 1,   TrxR↓, 9,   TrxR1↓, 2,   mt-TrxR1↓, 1,   xCT/SLC7A11↓, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   IronCh∅, 1,   STEAP3↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   p‑CDC2↓, 1,   CDC25↓, 5,   CDC25↑, 1,   compI↓, 7,   compII↓, 1,   compIII↓, 2,   compIII↑, 1,   compIV↓, 1,   compV↓, 1,   EGF↓, 2,   ETC↓, 10,   ETC↝, 1,   HSP60/HSPD1↑, 1,   Insulin↓, 3,   mitResp↓, 8,   mitResp↑, 1,   mtDam↑, 38,   OCR↓, 9,   OCR↑, 5,   OXPHOS↓, 9,   OXPHOS↑, 5,   mt-OXPHOS↓, 2,   mt-OXPHOS↑, 2,   PDH↑, 1,   p‑PDH↓, 2,   p‑PDH↑, 1,   PGC-1α↑, 2,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 4,   mt-TrxR2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   p‑ACC↑, 1,   ACLY↓, 1,   ALAT↓, 2,   AminoA↓, 1,   AMP↑, 1,   AMPK↑, 12,   p‑AMPK↑, 3,   ANXA7↑, 2,   ATP↓, 27,   ATP∅, 1,   ATP:AMP↓, 1,   cAMP↓, 1,   ECAR↓, 7,   ECAR↝, 1,   ECAR∅, 1,   FABP4↓, 1,   FAO↓, 1,   FAO↑, 1,   FASN↓, 1,   GAPDH↓, 2,   glucose↝, 1,   GlucoseCon↓, 16,   GlucoseCon∅, 1,   Glycolysis↓, 34,   Glycolysis∅, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 5,   p‑GSK‐3β↓, 1,   H2S↑, 1,   Histones↝, 1,   HK2?, 1,   HK2↓, 11,   HK2∅, 1,   HMG-CoA↓, 5,   IDO1↓, 2,   KeyT↑, 1,   lactateProd↓, 21,   lactateProd↑, 1,   lactateProd∅, 1,   LDHA↓, 5,   LDHA∅, 1,   LDL↓, 2,   lipidLev↓, 1,   lipoGen↓, 2,   MCT4↓, 1,   NAD↓, 2,   NADPH↓, 4,   NADPH↑, 2,   OAA↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 8,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 6,   PDKs↑, 1,   PFK↓, 2,   PFK1↓, 2,   PFKP↓, 1,   PKM1↑, 1,   PKM2↓, 9,   polyA↓, 1,   PPP↑, 1,   Pyruv↓, 1,   SCD1↓, 4,   SIRT1↓, 4,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   TCA?, 1,   TCA↓, 1,   TS↓, 2,   Warburg↓, 9,  

Cell Death(tgid=5) ⓘ

AIF↑, 17,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 11,   Apoptosis↑, 256,   Apoptosis∅, 1,   mt-Apoptosis↑, 4,   aSmase↑, 1,   BAD↓, 2,   BAD↑, 9,   Bak↑, 6,   BAX?, 1,   BAX↓, 2,   BAX↑, 87,   BAX⇅, 2,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 25,   Bcl-2?, 1,   Bcl-2↓, 95,   Bcl-2↑, 1,   Bcl-xL↓, 20,   BID↑, 4,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 2,   BNIP3?, 1,   Casp↓, 2,   Casp↑, 37,   Casp↝, 1,   Casp1↑, 2,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3?, 1,   Casp3↓, 4,   Casp3↑, 120,   cl‑Casp3↑, 25,   proCasp3↓, 1,   pro‑Casp3↓, 1,   pro‑Casp3↑, 1,   CASP4↑, 1,   Casp6↓, 1,   Casp6↑, 2,   Casp7↑, 21,   cl‑Casp7↑, 2,   Casp8↓, 2,   Casp8↑, 38,   cl‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 76,   cl‑Casp9↑, 5,   pro‑Casp9↑, 1,   cFLIP↓, 2,   Cupro↑, 2,   Cyt‑c↓, 2,   Cyt‑c↑, 84,   Cyt‑c↝, 1,   Diablo↑, 4,   DR5↑, 13,   Endon↑, 2,   FADD↑, 2,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 14,   FasL↑, 8,   Ferroptosis↑, 13,   GSDMC↑, 1,   GSDMD↑, 1,   IAP1↓, 2,   IAP1↑, 1,   IAP2/BIRC3↓, 2,   IAP2/BIRC3↑, 1,   ICAD↑, 1,   iNOS↓, 4,   Mcl-1↓, 10,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 6,   MDM2↑, 2,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↓, 2,   MOMP↑, 3,   Necroptosis↑, 3,   necrosis↑, 5,   NOXA↑, 2,   p38↓, 2,   p38↑, 8,   p‑p38↓, 1,   p‑p38↑, 6,   Paraptosis↑, 5,   PUMA↑, 5,   Pyro↑, 5,   RIP1↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   SK↓, 1,   survivin↓, 26,   TNFR 1↑, 1,   TRAIL↑, 5,   TumCD↓, 2,   TumCD↑, 50,   TUNEL↑, 1,   XIAP↓, 13,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 75,   Akt↑, 4,   p‑Akt↓, 28,   p‑Akt↑, 1,   AKT1↓, 3,   AMPKα↑, 1,   CaMKII ↓, 1,   Cavin3↓, 1,   CIP2A↓, 1,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 14,   p‑EGFR↓, 1,   ERK↓, 25,   ERK↑, 4,   p‑ERK↓, 10,   p‑ERK↑, 3,   HER2/EBBR2↓, 2,   Hippo↑, 1,   IGF-1R↓, 1,   p‑IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   IκB↓, 1,   IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK1↑, 1,   JAK2↓, 7,   JNK↓, 6,   JNK↑, 16,   p‑JNK↑, 7,   MAPK↓, 17,   MAPK↑, 8,   p‑MAPK↑, 2,   MARK4↓, 2,   MEK↓, 4,   MKP1↓, 1,   MKP2↓, 1,   mTOR↓, 36,   mTOR↑, 1,   mTOR⇅, 1,   p‑mTOR↓, 7,   mTORC2↑, 1,   p70S6↓, 1,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 47,   PI3K↑, 2,   p‑PI3K↓, 7,   PI3K/Akt↓, 1,   PIAS-3↑, 1,   PKA↓, 2,   PKCδ↓, 4,   PKCδ↑, 2,   PTEN↑, 12,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 4,   p‑S6K↓, 2,   SHP1↑, 1,   Sp1/3/4↓, 8,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 34,   STAT3↑, 1,   p‑STAT3↓, 6,   p‑STAT3↑, 2,   mt-STAT3↓, 1,   STAT4↓, 1,   STAT6↓, 2,   p‑STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1,   ATF3↑, 1,   ATF4↑, 6,   ATF4↝, 1,   BRD4↓, 1,   ChrMod↑, 2,   cJun↑, 3,   cMyc↓, 17,   cMyc↑, 1,   DNMT1↓, 6,   DNMT1↑, 1,   DNMTs↓, 5,   EZH2↓, 4,   FOXO↑, 2,   FOXO3↓, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↑, 2,   GATA3↓, 1,   H3↑, 2,   ac‑H3↑, 4,   ac‑H3↝, 1,   H4↑, 1,   ac‑H4↓, 1,   ac‑H4↑, 4,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 22,   HDAC1↓, 4,   HDAC2↓, 2,   HDAC3↓, 3,   HDAC4↓, 1,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-148a↑, 1,   miR-203↑, 1,   miR-21↓, 2,   miR-34a↑, 1,   miR-375↑, 1,   Myc↓, 1,   n-MYC↓, 1,   OCT4↓, 3,   other?, 1,   other↓, 2,   other↑, 15,   other⇅, 1,   other↝, 22,   other∅, 1,   PhotoS↑, 1,   PRMT6↓, 1,   SETBP1↓, 1,   SOX2↓, 2,   SOX4↓, 1,   SOX4↑, 1,   SUV39H↓, 1,   SUZ12↓, 1,   tumCV?, 1,   tumCV↓, 111,   tumCV↑, 4,   UTF1↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 21,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↓, 1,   p‑eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 40,   ERStress↑, 1,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 9,   HSP27↑, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 3,   HSP90↓, 7,   IRE1↑, 3,   PERK↓, 1,   PERK↑, 7,   p‑PERK↑, 1,   Proteasome?, 1,   Proteasome↓, 1,   UPR↑, 8,   XBP-1↓, 1,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 6,   ATG7↑, 3,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 6,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B↑, 2,   LC3B-II↓, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↑, 9,   LC3s↓, 1,   lysoMP↑, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 6,   p‑p62↑, 1,   PARK2↑, 1,   SESN2↑, 1,   TumAuto?, 1,   TumAuto↓, 1,   TumAuto↑, 30,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DNA-PK↑, 2,   DNAdam↓, 1,   DNAdam↑, 85,   DNArepair↓, 2,   DNArepair↑, 1,   FEN1↓, 1,   G9a↓, 1,   hTERT/TERT↓, 5,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 70,   P53↝, 3,   p‑P53↑, 3,   p53 Wildtype↓, 1,   p53 Wildtype↑, 1,   PARP↓, 9,   PARP↑, 13,   PARP↝, 1,   p‑PARP↑, 2,   cl‑PARP↓, 1,   cl‑PARP↑, 58,   PARP1↑, 2,   cl‑PARP1↑, 2,   PCNA↓, 15,   PCNA↑, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 8,   TOP1↓, 4,   TOP1↝, 1,   TOP2↓, 2,   TOP2↑, 2,   TP53↑, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↑, 9,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   BRD4↓, 1,   CC(CDKs/cyclins)↓, 1,   CC(CDKs/cyclins)↑, 1,   CDK1↓, 7,   CDK1↑, 1,   CDK2↓, 29,   CDK2↑, 1,   CDK4↓, 33,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK6↓, 9,   CDK6↑, 3,   CDK8↓, 1,   CDKN1C/p57↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   CycB/CCNB1↓, 15,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 48,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 16,   cycE1↓, 2,   cycF↑, 1,   E2Fs↓, 2,   FBXO5/EMI1↓, 1,   GADD34↑, 1,   GADD45A↑, 2,   Ki-67↓, 14,   P21?, 1,   P21↓, 5,   P21↑, 48,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 21,   PLK1↓, 1,   pRB↓, 1,   pRB↑, 1,   p‑pRB↓, 2,   p‑RB1↓, 4,   TubPol↓, 1,   TumCCA?, 3,   TumCCA↓, 4,   TumCCA↑, 178,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 2,   ALDH1A3↓, 1,   BMI1↓, 1,   CD133↓, 3,   CD24↓, 4,   cFos↓, 1,   cFos↑, 1,   cMYB↓, 1,   CSCs↓, 36,   CSCs↑, 1,   Diff↓, 3,   Diff↑, 7,   EP4/PTGER4↓, 1,   HH↓, 2,   HH↝, 1,   HMGCR↓, 1,   HMGCR↑, 1,   IGF-1↓, 3,   IGFBP3↑, 1,   Ki-67↓, 14,   mTORC1↓, 1,   p‑mTORC1↓, 1,   Nanog↓, 2,   Nestin↓, 2,   NOTCH↓, 6,   NOTCH↝, 1,   NOTCH1↓, 5,   NOTCH3↓, 2,   p300↓, 1,   SCF↓, 1,   Shh↓, 2,   STAT1↓, 1,   TOPflash↓, 1,   TumCG?, 1,   TumCG↓, 121,   TumCG↑, 4,   TumCG∅, 2,   TumCP?, 1,   TumCP↓, 140,   TumCP↑, 2,   Wnt↓, 21,   Wnt↝, 1,   Wnt/(β-catenin)↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 7,   ATPase↓, 1,   CA↓, 1,   Ca+2↓, 7,   Ca+2↑, 34,   Ca+2↝, 4,   i-Ca+2?, 1,   i-Ca+2↑, 2,   cal2↑, 1,   Cav1↑, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   Cdc42↑, 1,   i-Chl↑, 1,   Cofilin↓, 1,   p‑Cofilin↑, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 20,   EMT↓, 37,   EpCAM↓, 1,   F-actin↓, 2,   FAK↓, 5,   FAK↑, 1,   FAK↝, 1,   p‑FAK↓, 2,   fascin↓, 1,   Fibronectin↓, 2,   FOSB↑, 1,   ITGB1↓, 2,   ITGB3↓, 1,   ITGB6↓, 1,   KRAS↓, 1,   MALAT1↓, 2,   MMP1↓, 1,   MMP2↓, 45,   MMP2↑, 1,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 45,   MMPs↓, 11,   MUC4↓, 1,   N-cadherin?, 1,   N-cadherin↓, 10,   N-cadherin↑, 1,   PAK1↓, 2,   PDGF↓, 4,   Rac1↓, 2,   RECK↑, 2,   Rho↓, 3,   ROCK1↓, 1,   Slug↓, 4,   Smad1↑, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   Snail↓, 9,   TET1↑, 1,   TG2/TGase↓, 1,   TGF-β↓, 6,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↑, 6,   TIMP3↑, 1,   TSC1↑, 1,   TumCA↑, 1,   TumCI↓, 58,   TumCMig↓, 67,   TumMeta↓, 43,   TumMeta↑, 1,   Twist↓, 12,   uPA↓, 7,   Vim↓, 10,   Zeb1↓, 7,   ZEB2↓, 1,   α-tubulin↓, 2,   β-catenin/ZEB1↓, 23,   β-catenin/ZEB1↑, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 55,   angioG↑, 3,   CD31/PECAM-1↓, 1,   CD31/PECAM-1↑, 1,   EGR1↑, 1,   Endoglin↑, 2,   HIF-1↓, 5,   Hif1a↓, 31,   Hif1a↑, 2,   HIF2a↓, 1,   Hypoxia↓, 1,   LOX1↓, 1,   NO↓, 2,   NO↑, 7,   PHDs↓, 1,   VCAM-1↓, 1,   VEGF↓, 43,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 9,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 2,   CellMemb↑, 2,   CLDN1↓, 1,   CTR1↑, 1,   EPR↑, 9,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT2↓, 2,   GLUT4↓, 1,   MMP?, 2,   MMP↓, 152,   MMP↝, 1,   MPT↓, 1,   MPT↑, 9,   NHE1↓, 2,   sonoP↑, 1,   SVCT-2↓, 1,   TRPC1↑, 1,   TRPM7↓, 1,   TRPV1↓, 1,   TRPV1↑, 4,   TRPV2↑, 1,   VGCC↑, 1,   VGSC↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

B2M↓, 1,   CCR7↓, 1,   CD4+↑, 1,   CD44↓, 10,   CD47↓, 1,   CD8+↑, 4,   cDC2↓, 1,   p‑cDC2↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 32,   COX2/PTGS2↑, 4,   CXCc↓, 1,   CXCR4↓, 3,   DCells↑, 2,   DR4↑, 3,   DR6↑, 1,   FOXP3↓, 1,   HMGB1↓, 2,   ICAM-1↓, 3,   Igs↑, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 7,   IL1β↑, 3,   IL2↑, 1,   IL6↓, 15,   IL8↓, 4,   IL8↑, 1,   Imm↑, 9,   Imm↝, 1,   INF-γ↑, 1,   Inflam↓, 28,   LIF↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 1,   NF-kB↓, 71,   NF-kB↑, 9,   p‑NF-kB↑, 2,   NK cell↑, 8,   NLRP3↓, 1,   NLRP3↑, 3,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   PD-L1↓, 3,   PGE2↓, 8,   PSA↓, 5,   RAGE↓, 1,   SOCS-3↓, 1,   SOCS-3↑, 1,   T-Cell↑, 2,   Th1 response↑, 1,   Th2↑, 1,   TLR4↓, 3,   TNF-α↓, 17,   TNF-α↑, 6,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   pH↝, 2,   e-pH↑, 1,   i-pH↓, 1,   i-pH↑, 2,  

Protein Aggregation(tgid=19) ⓘ

PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   AhR↑, 1,   AR↓, 9,   CYP24A1↓, 1,   ER-α36↓, 2,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 31,   BioAv↑, 33,   BioAv↝, 5,   BioEnh↑, 1,   chemoR↓, 2,   ChemoSen↓, 1,   ChemoSen↑, 153,   ChemoSen∅, 3,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 8,   Dose↓, 10,   Dose↑, 15,   Dose⇅, 1,   Dose↝, 81,   Dose∅, 18,   eff?, 1,   eff↓, 87,   eff↑, 140,   eff↝, 22,   GSTP1/GSTπ↓, 1,   GSTZ1↓, 1,   Half-Life?, 1,   Half-Life↓, 6,   Half-Life↑, 4,   Half-Life↝, 11,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1∅, 1,   P450↓, 1,   P450↑, 1,   P450↝, 1,   RadioS↓, 1,   RadioS↑, 64,   selectivity?, 9,   selectivity↓, 10,   selectivity↑, 676,   selectivity↝, 2,   selectivity∅, 4,   Synergy↑, 91,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 9,   AST↓, 1,   B2M↓, 1,   BG↓, 4,   BloodF↑, 1,   BMD↑, 1,   BRCA1↓, 1,   p‑BRCA1↑, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 14,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   EZH2↓, 4,   Ferritin↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 5,   IL6↓, 15,   KeyT↑, 1,   KRAS↓, 1,   LDH?, 1,   LDH↓, 5,   LDH↑, 6,   Maspin↑, 1,   Myc↓, 1,   NOS2↓, 2,   NOS2↑, 1,   PD-L1↓, 3,   PSA↓, 5,   RAGE↓, 1,   SUZ12↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 55,   AntiCan∅, 1,   antiCG↓, 1,   AntiDiabetic↑, 1,   antiNeop↑, 1,   antiNeop∅, 1,   AntiTum↓, 1,   AntiTum↑, 24,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 6,   CardioT↓, 1,   chemoP↑, 29,   chemoPv↑, 21,   ChemoSideEff↓, 3,   fatigue↓, 1,   hepatoP↑, 10,   hepatoP∅, 1,   neuroP↑, 8,   NP/CIPN↓, 1,   OS↑, 30,   OS⇅, 1,   OS∅, 1,   Pain↓, 4,   PDE4↓, 1,   PFS↑, 1,   QoL↑, 9,   radioP↑, 16,   Remission↑, 2,   RenoP↑, 4,   Risk↓, 13,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 28,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 13,   toxicity∅, 5,   TumVol↓, 36,   TumW↓, 17,   Weight↑, 4,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiP↑, 4,   Bacteria↓, 5,   GutMicro↑, 3,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 5,  
Total Targets: 956

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 2,   antiOx↑, 68,   mt-antiOx↑, 1,   ARE↑, 1,   Catalase↑, 21,   Copper↓, 1,   Fenton↓, 2,   GPx↑, 18,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 18,   GSH/GSSG↑, 1,   GSR↑, 2,   GSSG↓, 1,   GSSG∅, 1,   GSTs↑, 7,   H2O2↓, 1,   H2O2↑, 1,   HDL↓, 1,   HDL↑, 3,   HO-1↑, 13,   hyperG↓, 1,   Iron↓, 2,   Iron↑, 1,   Iron∅, 1,   lipid-P↓, 15,   MDA↓, 12,   MPO↓, 2,   NOX↓, 1,   NOX4↓, 1,   Nrf1↑, 1,   NRF2↑, 21,   Prx↑, 1,   Prx4∅, 1,   RNS↓, 3,   ROS?, 2,   ROS↓, 64,   ROS↑, 4,   ROS∅, 18,   SAM-e↑, 1,   selenoP↑, 2,   SOD?, 1,   SOD↓, 1,   SOD↑, 23,   SOD1↑, 3,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 2,   VitC↑, 2,   VitE↓, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   EGF↓, 1,   mitResp↑, 1,   OCR↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ACLY∅, 1,   ALAT↓, 4,   AMPK↑, 1,   ATP↑, 4,   ATP↝, 1,   ECAR↓, 1,   GlucoseCon↑, 2,   Glycolysis↓, 2,   Glycolysis↑, 1,   GSK‐3β↓, 2,   HK2↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDL↓, 4,   lipidLev↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   NADPH∅, 1,   PFK↓, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 3,   Casp3∅, 1,   cl‑Casp8↑, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 5,   p38↓, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↓, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   JAK2↑, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 1,   mTOR↓, 4,   PI3K↑, 2,   PKCδ?, 1,   PTEN↑, 1,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   other↓, 2,   other↑, 2,   other↝, 7,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   p‑PERK↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10,   DNAdam↑, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cellSen↑, 1,   GADD45A↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   Diff↑, 1,   EP2↓, 1,   FGF↑, 1,   neuroG↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 4,   Ca+2↑, 1,   Ca+2↝, 2,   Ca+2∅, 1,   i-Ca+2↓, 1,   MMP13↓, 1,   MMP9↓, 1,   MMPs↑, 1,   PDGF↑, 1,   serineP↓, 1,   TGF-β↑, 2,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   Hif1a↑, 2,   NO↓, 4,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   GastroP↑, 1,   GLUT1↓, 1,   IBI↑, 1,   MMP↑, 2,   MMP∅, 2,   SVCT-2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 10,   FOXP3↑, 1,   HMGB1↓, 1,   IFN-γ↓, 3,   IL1↑, 1,   IL10↓, 1,   IL10↑, 2,   IL17↓, 2,   IL1β↓, 9,   IL23↓, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 8,   IL8↓, 1,   Imm↑, 7,   Inflam↓, 61,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 3,   NF-kB↓, 14,   NLRP3↓, 2,   NLRP3↑, 1,   PGE2↓, 2,   PSA∅, 1,   TLR4↓, 1,   TNF-α↓, 11,   TNF-α↑, 1,   Treg lymp↝, 1,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 3,   AChE↑, 1,   BDNF↑, 5,   MAOA↓, 2,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 7,   BACE/β-secretase↓, 1,   tau↓, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 3,   PPARγ↑, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 19,   BioAv↑, 21,   BioAv↝, 5,   BioEnh↑, 1,   CompStab↑, 2,   CompStab↝, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 13,   eff↑, 9,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 3,   Half-Life∅, 2,   P450↓, 1,   selectivity↑, 13,   selectivity⇅, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 2,   AST↓, 4,   BG↓, 1,   BMD↑, 2,   BP↓, 4,   Calcium↑, 1,   creat↓, 2,   CRP↓, 3,   HbA1c↓, 1,   HOMA↓, 1,   hs-CRP↓, 2,   IL6↓, 8,   LDH↓, 1,   Mag↑, 1,   PSA∅, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 2,   Urea↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 5,   antiAll↑, 7,   AntiArt↑, 2,   AntiCan↓, 1,   AntiCan↑, 9,   AntiDiabetic↑, 10,   antiPs↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 16,   CardioT↓, 1,   chemoP↑, 12,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↑, 5,   diuretic↑, 1,   hepatoP↑, 11,   memory↑, 8,   neuroP↑, 28,   Obesity↓, 4,   OS↑, 3,   Pain↓, 3,   radioP↑, 5,   RenoP↑, 3,   Risk↓, 2,   Stress↓, 1,   Stroke↓, 2,   toxicity?, 2,   toxicity↓, 53,   toxicity↝, 11,   toxicity∅, 19,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiViral↑, 3,   Bacteria↓, 15,   GutMicro↑, 5,   Inf↓, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 313

Scientific Paper Hit Count for: selectivity, selectivity
35 Silver-NanoParticles
30 Magnetic Fields
20 Radiotherapy/Radiation
17 Piperlongumine
14 Selenium NanoParticles
13 Thymoquinone
12 Chemotherapy
12 Betulinic acid
12 Dandelion Root
10 Vitamin C (Ascorbic Acid)
10 doxorubicin
10 chitosan
10 Sulforaphane (mainly Broccoli)
10 Dichloroacetate
10 salinomycin
10 Fisetin
10 Phenethyl isothiocyanate
10 Shikonin
9 Capsaicin
9 Propolis -bee glue
9 Cisplatin
9 Magnetic Field Rotating
8 Carvacrol
8 Copper and Cu NanoParticles
8 Hydrogen Gas
8 Honokiol
8 Ivermectin
8 Magnolol
8 Quercetin
8 Selenite (Sodium)
7 Artemisinin
7 Berberine
7 Curcumin
7 Kaempferol
6 3-bromopyruvate
6 Fenbendazole
6 Apigenin (mainly Parsley)
6 Ashwagandha(Withaferin A)
6 Melatonin
6 Baicalein
6 Chrysin
6 Lemongrass Extract/Citral
6 EGCG (Epigallocatechin Gallate)
6 Gallic acid
6 HydroxyTyrosol
6 Linalool
5 Rosmarinic acid
5 Metformin
5 Boron
5 Selenium
5 Ellagic acid
5 Hibiscus sabdariffa
5 Indole-3-carbinol
5 Licochalcone A
4 Alpha-Lipoic-Acid
4 Phenylbutyrate
4 Gold NanoParticles
4 α-Bisabolol / Chamomile oil
4 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
4 chaetocin
4 diet FMD Fasting Mimicking Diet
4 diet Methionine-Restricted Diet
4 Eurycomanone
4 Eugenol
4 Graviola
4 phytic acid, Inositol hexakisphosphate
4 Lactoferrin/Talactoferrin
4 Luteolin
4 Lutein
4 Lycopene
4 mebendazole
4 Methyl Jasmonate
4 Morin
4 Parthenolide
4 α-Santalol/Sandalwood oil
4 Terpinen-4-ol / Tea Tree Oil
4 VitK3,menadione
3 1,8-Cineole
3 chemodynamic therapy
3 Allicin (mainly Garlic)
3 Astaxanthin
3 Atorvastatin
3 Caffeic acid
3 Centella asiatica / Gotu kola → asiaticoside
3 Citric Acid
3 Coenzyme Q10
3 Cynaropicrin
3 Date Fruit Extract
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Helleborus niger extracts – Christmas Rose
3 Isobavachalcone
3 Isoliquiritigenin
3 isoorientin
3 isoquercitrin
3 Recombinant Methioninase
3 Nimbolide
3 Urolithin
2 Dipyridamole
2 Berbamine
2 Bifidobacterium
2 immunotherapy
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Crocetin
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Hydroxycinnamic-acid
2 Dihydrocaffeic Acid
2 Docosahexaenoic Acid
2 Oxygen, Hyperbaric
2 D-limonene
2 Disulfiram
2 Electrical Pulses
2 Evodiamine
2 Fucoidan
2 Gambogic Acid
2 Ginkgo biloba
2 Geldanamycin
2 Gossypol/AT-101
2 Hyperthermia
2 Hyperoside
2 Inositol
2 iodine
2 Juglone
2 Licorice
2 Methylene blue
2 methylseleninic acid
2 Methylglyoxal
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Marjoram (Origanum majorana)
2 SonoDynamic Therapy UltraSound
2 Plumbagin
2 Sulfasalazine
2 polyethylene glycol
2 Silymarin (Milk Thistle) silibinin
2 Aflavin-3,3′-digallate
2 Vitexin
2 Zerumbone
1 Auranofin
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Sorafenib (brand name Nexavar)
1 5-Aminolevulinic acid
1 Baicalin
1 Bufalin/Huachansu
1 probiotics
1 Brucea javanica
1 Brutieridin–Melitidin Mixture
1 Boswellia (frankincense)
1 Bullatacin
1 Butyrate
1 Carnosic acid
1 urea
1 Thymol-Thymus vulgaris
1 Cat’s Claw
1 Cannabidiol
1 Chocolate
1 Calorie Restriction Mimetics
1 Carvone
1 Polyphenols
1 Cucurbitacin
1 Cysteamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Diclofenac
1 diet Ketogenic
1 Docetaxel
1 Dimethyl Sulfoxide
1 Mistletoe/Viscum album Extracts
1 Echinacea
1 Ginkgo biloba-EGb 761
1 5-fluorouracil
1 PXD, phenoxodiol
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 ferumoxytol
1 Formononetin
1 Flaxseed/Linseed
1 Flaxseed Oil
1 olaparib/LYNPARZA
1 Garcinol
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgetin
1 Ginseng
1 Grapeseed extract
1 High-Ozonide Oil
1 Paclitaxel/Taxol
1 Gemcitabine (Gemzar)
1 isoflavones
1 Isovitexin
1 Lactobacillus
1 lambertianic acid
1 low dose naltrexone
1 Photodynamic Therapy
1 Matrine
1 Mung Bean Sprouts
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Mushroom Chaga, Inonotus obliquus
1 Bicarbonate(Sodium)
1 Oleuropein
1 Propyl gallate
1 temozolomide
1 borneol
1 Psoralidin
1 Pterostilbene
1 Resveratrol
1 irinotecan
1 triptolide
1 Ursolic acid
1 Vitamin B1/Thiamine
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1110  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page