| Source: |
| Type: type of cell death |
| Situation in which a cell actively pursues a course toward death upon receiving certain stimuli. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. |
| 5638- | BCA, | Investigating the Anticancer Potential of Biochanin A in KB Oral Cancer Cells Through the NFκB Pathway |
| - | in-vitro, | Oral, | NA |
| 5639- | BCA, | Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition |
| - | in-vitro, | BC, | NA |
| 6517- | BCP, | β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways |
| - | in-vivo, | Nor, | NA |
| 6513- | BCP, | β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products |
| - | in-vitro, | Var, | NA |
| 6512- | BCP, | Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells |
| - | in-vitro, | MM, | NA |
| 6496- | BCP, | β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models |
| - | vitro+vivo, | CRC, | HCT116 | - | in-vitro, | Nor, | HUVECs |
| 6497- | BCP, | Cisplatin, | Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules |
| - | in-vitro, | Lung, | NA |
| 6498- | BCP, | β-Caryophyllene induces apoptosis and inhibits cell proliferation by deregulation of STAT-3/mTOR/AKT signaling in human bladder cancer cells: An in vitro study |
| - | in-vitro, | CRC, | T24/HTB-9 | - | in-vitro, | Bladder, | 5637 |
| 6499- | BCP, | JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation |
| - | in-vitro, | OS, | MG63 |
| 6500- | BCP, | Beta-Caryophyllene Suppresses Ovarian Cancer Proliferation by Inducing Cell Cycle Arrest and Apoptosis |
| - | in-vitro, | Ovarian, | NA |
| 6501- | BCP, | β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study |
| - | in-vitro, | Oral, | KB |
| 6503- | BCP, | The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer |
| - | Review, | Var, | NA |
| 6504- | BCP, | β-Caryophyllene Induces PPARγ-Mediated Apoptosis and Enhances the Radiosensitivity in Colorectal Cancer Cells |
| - | in-vitro, | CRC, | CT26 | - | in-vitro, | CRC, | HCT116 |
| 6509- | BCP, | βcaryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells |
| - | in-vitro, | Lung, | A549 |
| 5510- | bemA, | Combined inhibition of ACLY and CDK4/6 reduces cancer cell growth and invasion |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | PC, | NA |
| 5582- | BetA, | Targeting mitochondrial apoptosis by betulinic acid in human cancers |
| - | Review, | Var, | NA |
| 5592- | BetA, | Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells |
| - | in-vitro, | Liver, | HepG2 | - | in-vitro, | Cerv, | HeLa |
| 5587- | BetA, | Rad, | Effects of betulinic acid alone and in combination with irradiation in human melanoma cells |
| - | in-vitro, | Melanoma, | NA |
| 5584- | BetA, | Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors |
| - | in-vitro, | GBM, | A172 | - | in-vitro, | GBM, | U118MG | - | in-vitro, | GBM, | U251 |
| 2719- | BetA, | Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential |
| - | in-vitro, | CRC, | T24/HTB-9 | - | in-vitro, | Bladder, | UMUC3 | - | in-vitro, | Bladder, | 5637 |
| 2718- | BetA, | The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis |
| - | in-vitro, | AML, | U937 |
| 2717- | BetA, | Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma |
| - | in-vitro, | Melanoma, | U266 | - | in-vivo, | Melanoma, | NA | - | in-vitro, | Melanoma, | RPMI-8226 |
| 2723- | BetA, | Betulinic acid and oleanolic acid modulate CD81 expression and induce apoptosis in triple-negative breast cancer cells through ROS generation |
| - | in-vitro, | BC, | MDA-MB-231 |
| 2724- | BetA, | Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice |
| - | in-vivo, | Nor, | NA | - | in-vivo, | Stroke, | NA |
| 2727- | BetA, | Betulinic acid in the treatment of breast cancer: Application and mechanism progress |
| - | Review, | BC, | NA |
| 2733- | BetA, | Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling |
| - | in-vitro, | Oral, | KB | - | in-vivo, | NA, | NA |
| 2734- | BetA, | Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | SW480 |
| 2735- | BetA, | Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications |
| - | Review, | Var, | NA |
| - | Review, | Var, | NA |
| 2757- | BetA, | Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways |
| - | in-vitro, | GBM, | U251 |
| 2739- | BetA, | Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells |
| - | in-vitro, | Nor, | HUVECs | - | in-vitro, | Nor, | MEF |
| 2743- | BetA, | Betulinic acid and the pharmacological effects of tumor suppression |
| - | Review, | Var, | NA |
| 2744- | BetA, | Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential |
| - | Review, | Var, | NA |
| 2745- | BetA, | Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors |
| - | in-vitro, | CRC, | RKO | - | in-vitro, | CRC, | SW480 | - | in-vivo, | NA, | NA |
| 2750- | BetA, | GEM, | Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation |
| - | in-vitro, | PC, | Bxpc-3 | - | in-vitro, | Lung, | H1299 |
| 2753- | BetA, | Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells |
| - | in-vitro, | Cerv, | HeLa |
| 1305- | BetA, | Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells |
| - | in-vitro, | UEC, | NA |
| 1285- | BetA, | Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells |
| - | in-vitro, | Var, | NA |
| 5722- | BF, | Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells |
| - | in-vitro, | PC, | PANC1 |
| 5729- | BF, | Bufalin: a potential drug for regulating EGFR-TKIs resistance in lung cancer via the EGFR-PI3K/Akt-mTOR signaling |
| - | in-vitro, | Lung, | NA |
| 5724- | BF, | A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in Mice |
| - | vitro+vivo, | Lung, | A549 |
| 5726- | BF, | Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain |
| - | Review, | neuroblastoma, | SK-N-BE |
| 5727- | BF, | Bufalin Inhibits Proliferation and Induces Apoptosis in Osteosarcoma Cells by Downregulating MicroRNA-221 |
| - | in-vitro, | OS, | U2OS |
| 5728- | BF, | Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action |
| - | in-vitro, | Lung, | A549 |
| 5718- | BF, | Bufalin inhibits CYP3A4 activity in vitro and in vivo |
| - | in-vivo, | Nor, | NA |
| 5715- | BF, | Bufalin for an innovative therapeutic approach against cancer |
| - | Review, | Var, | NA |
| 1250- | Bif, | Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12 |
| - | in-vitro, | SCC, | NA |
| 9207- | BITC, | Benzyl isothiocyanate–induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | MCF-10AT |
| 9211- | BITC, | Apoptosis induced by benzyl isothiocyanate in gefitinib-resistant lung cancer cells is associated with Akt/MAPK pathways and generation of reactive oxygen species |
| - | in-vitro, | NSCLC, | NA |
| 9162- | BITC, | Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells |
| - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MCF7 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:14 State#:% Dir#:%
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