Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱

Source:

Type: type of cell death

Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.

Scientific Papers found: Click to Expand⟱

6504-

BCP,

β-Caryophyllene Induces PPARγ-Mediated Apoptosis and Enhances the Radiosensitivity in Colorectal Cancer Cells

-

in-vitro,

CRC,

CT26

-

in-vitro,

CRC,

HCT116

RadioS↑, TumCCA↑, γH2AX↑, DNAdam↑, p‑Akt↓, cycD1/CCND1↓, PPARγ↑, Bax:Bcl2↑, Casp3↑, Apoptosis↑,

6509-

BCP,

βcaryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells

-

in-vitro,

Lung,

A549

tumCV↓, TumCP↓, Ki-67↓, PCNA↓, P21↓, P53↑, DNAdam↑, TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑, BAX↑, Bcl-2↓, GSH↑, GPx↑, 4-HNE↑, ROS↓, antiOx↑, lipid-P↓,

5510-

bemA,

Combined inhibition of ACLY and CDK4/6 reduces cancer cell growth and invasion

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

PC,

NA

eff↑, Apoptosis↑, TumCI↓, ACLY↓, LDL↓, eff↑, TumCP↓,

5582-

BetA,

Targeting mitochondrial apoptosis by betulinic acid in human cancers

-

Review,

Var,

NA

Apoptosis↑, MMP↓, Cyt‑c↑, ROS↑, NF-kB↑, angioG↓, mtDam↑, TOP1↓, selectivity↑, ChemoSen↑, TumCG↓, chemoPv↑, RadioS↑,

5592-

BetA,

Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells

-

in-vitro,

Liver,

HepG2

10 to 15 mg/mL

-

in-vitro,

Cerv,

HeLa

Casp3↑, Casp9↑, cl‑PARP↑, Apoptosis↑, Cyt‑c↑, MMP↓,

5587-

BetA,

Rad,

Effects of betulinic acid alone and in combination with irradiation in human melanoma cells

-

in-vitro,

Melanoma,

NA

TumCG↓, RadioS↑, Apoptosis↑, selectivity↑,

5584-

BetA,

Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors

-

in-vitro,

GBM,

A172

-

in-vitro,

GBM,

U118MG

-

in-vitro,

GBM,

U251

Apoptosis↑, P53↑, Cyt‑c↑, AIF↑, Casp↑, AntiTum↑, MMP↓,

2723-

BetA,

Betulinic acid and oleanolic acid modulate CD81 expression and induce apoptosis in triple-negative breast cancer cells through ROS generation

-

in-vitro,

BC,

MDA-MB-231

Apoptosis↑, tumCV↓, ROS↑,

2718-

BetA,

The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis

-

in-vitro,

AML,

U937

TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,

2719-

BetA,

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

-

in-vitro,

CRC,

T24/HTB-9

30 μg/mL BA for 48 h

-

in-vitro,

Bladder,

UMUC3

33.2 μg/mL

-

in-vitro,

Bladder,

5637

 28.5 μg/mL

TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,

2734-

BetA,

Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer

-

in-vitro,

CRC,

HCT116

6.441 µg/mL (14.15 µM)

-

in-vitro,

CRC,

SW480

1.67 µg/mL (3.670 µM)

tumCV↓, HSP70/HSPA5⇅, ROS↑, cl‑Casp3↑, mt-Apoptosis↑, Dose↝,

2724-

BetA,

Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice

-

in-vivo,

Nor,

NA

mice

-

in-vivo,

Stroke,

NA

AntiTum↑, *Inflam↓, *ROS↓, *NOX4↓, *Apoptosis↓, neuroP↑,

2727-

BetA,

Betulinic acid in the treatment of breast cancer: Application and mechanism progress

-

Review,

BC,

NA

mt-ROS↑, Sp1/3/4↓, TumMeta↓, GlucoseCon↓, NF-kB↓, ChemoSen↑, chemoP↑, m-Apoptosis↑, TOP1↓,

2717-

BetA,

Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma

-

in-vitro,

Melanoma,

U266

10-40uM

-

in-vivo,

Melanoma,

NA

Nude Mouse Xenograft Model

-

in-vitro,

Melanoma,

RPMI-8226

Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, NF-kB↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP1↑, MDA↑, SOD↓, SOD2↓, GCLM↓, GSTA1↓, FTH1↓, GSTs↓, TumVol↓,

2733-

BetA,

Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling

-

in-vitro,

Oral,

KB

12.5–100 μM BA for 24–72 h

-

in-vivo,

NA,

NA

BA against OSCC in implanted mice in vivo

TumCP↓, TumVol↓, mt-Apoptosis↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↑, OCR↓, TumCCA↑, ROS↑, eff↓, P53↑, STAT3↓, cycD1/CCND1↑,

2735-

BetA,

Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications

-

Review,

Var,

NA

mt-Apoptosis↑, Casp↑, p38↑, MAPK↓, JNK↓, VEGF↓, AIF↑, Cyt‑c↑, ROS↑, Ca+2↑, ATP↓, NF-kB↓, ATF3↓, TOP1↓, VEGF↓, survivin↓, Sp1/3/4↓, MMP↓, ChemoSen↑, selectivity↑, BioAv↓, BioAv↑, BioAv↑, BioAv↑, BioAv↑,

2736-

BetA,

Chemo,

Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis

-

Review,

Var,

NA

chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,

2757-

BetA,

Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways

-

in-vitro,

GBM,

U251

tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, Ferroptosis↑, HO-1↑, NRF2↑,

2739-

BetA,

Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells

-

in-vitro,

Nor,

HUVECs

10 µM

-

in-vitro,

Nor,

MEF

*Glycolysis↑, *GlucoseCon↑, *Apoptosis↓, *UCP1↓, *AMPK↑, GLUT1↑, mt-ROS↑,

2743-

BetA,

Betulinic acid and the pharmacological effects of tumor suppression

-

Review,

Var,

NA

ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, TumCCA↑, Sp1/3/4↓, STAT3↓, NF-kB↓, EMT↓, TOP1↓, MAPK↑, p38↑, JNK↑, Casp↑, Bcl-2↓, BAX↑, VEGF↓, LAMs↓,

2744-

BetA,

Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential

-

Review,

Var,

NA

Apoptosis↓, TumCCA↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, MMP↓, ROS↑, TOP1↓, NF-kB↓,

2745-

BetA,

Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

-

in-vitro,

CRC,

RKO

-

in-vitro,

CRC,

SW480

-

in-vivo,

NA,

NA

nude mice

Apoptosis↑, TumCG↓, Sp1/3/4↓, survivin↓, VEGF↓, p65↓, EGFR↓, cycD1/CCND1↓, ROS↑, MMP↓,

2750-

BetA,

GEM,

Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation

-

in-vitro,

PC,

Bxpc-3

-

in-vitro,

Lung,

H1299

CHK1↓, ChemoSen↑, tumCV↓, Apoptosis↑, DNAdam↑,

2753-

BetA,

Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells

-

in-vitro,

Cerv,

HeLa

30 µmol/l BA

PI3K↓, p‑Akt↓, ROS↑, TumCCA↑, p27↑, P21↑, mt-Apoptosis↑, BAD↑, Casp9↑, MMP↓, eff↓,

1305-

BetA,

Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells

-

in-vitro,

UEC,

NA

Apoptosis↑, Bcl-2↓, BAX↑,

1285-

BetA,

Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells

-

in-vitro,

Var,

NA

Apoptosis↑, Bcl-2↓, cycD1/CCND1↓, BAX↑,

5722-

BF,

Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells

-

in-vitro,

PC,

PANC1

Apoptosis↑, TumCCA↑, HSP27↓, p‑Akt↓, proCasp3↑, proCasp9↑, Bcl-2↝, BAX↝, eff↑,

5729-

BF,

Bufalin: a potential drug for regulating EGFR-TKIs resistance in lung cancer via the EGFR-PI3K/Akt-mTOR signaling

-

in-vitro,

Lung,

NA

TumCCA↑, Apoptosis↑, TumCG↓, EGFR↓, PI3K↓, Akt↓, mTOR↓, P70S6K↓,

5724-

BF,

A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in Mice

-

vitro+vivo,

Lung,

A549

mice

Apoptosis↑, Casp3↑, cl‑PARP↑,

5726-

BF,

Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain

-

Review,

neuroblastoma,

SK-N-BE

90 and 30 nM at 72 h

Apoptosis↑, TumCP↓, TumCMig↓, MMP↓, ROS↑, ETC↓, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, eff↓, TumCG↓, Ki-67↓, PCNA↓,

5727-

BF,

Bufalin Inhibits Proliferation and Induces Apoptosis in Osteosarcoma Cells by Downregulating MicroRNA-221

-

in-vitro,

OS,

U2OS

TumCP↓, Apoptosis↑, ROS↑, miR-221↓,

5728-

BF,

Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action

-

in-vitro,

Lung,

A549

TumCP↓, Apoptosis↑, TumCCA↑, Bcl-2↝, BAX↝, Cyt‑c↝, Casp3↝, PARP↝, P21↝, cycD1/CCND1↝, COX2↝, p‑VEGFR2↓, EGFR↓, Akt↓, NF-kB↓, p44↓,

5718-

BF,

Bufalin inhibits CYP3A4 activity in vitro and in vivo

-

in-vivo,

Nor,

NA

Wistar rats

CYP3A4↓, Apoptosis↑, AntiTum↑,

5715-

BF,

Bufalin for an innovative therapeutic approach against cancer

-

Review,

Var,

NA

selectivity↑, TumCP↓, TumCCA↓, TumCD↑, Apoptosis↑, TumAuto↑, TumMeta↓, TumCMig↓, TumCI↓, angioG↓, CSCs↓,

1250-

Bif,

Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12

-

in-vitro,

SCC,

NA

TumCG↓, Apoptosis↑, CCL20↑, IL12↑,

5688-

BJ,

Brucea Javanica Oil Emulsion Injection inhibits proliferation of pancreatic cancer via regulating apoptosis-related genes

-

vitro+vivo,

PC,

MIA PaCa-2

Female C57BL/6 mice, aged 4 weeks

TumCG↓, TumCI↓, TumCCA↑, Apoptosis↑, BAX↑, cl‑Casp3↑, Bcl-2↓, MMP2↓, BACE↓, TOP2↓,

5687-

BJ,

Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways

-

vitro+vivo,

AML,

U937

in vitro and in a mouse U937 xenograft tumor model.

Apoptosis↑, Casp8↑, TumCCA↑, cl‑PARP↑, eff↝, TumCG↓, necrosis↑, Fas↑, TumCCA↑, selectivity↑,

5690-

BJ,

BRU,

Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica

-

Review,

Var,

NA

NRF2↓, TumCG↓, ChemoSen↑, ROS↑, NF-kB↓, Akt↓, mTOR↓, TumCCA↑, Apoptosis↑, PARP↑, Casp↑, P53↓, Bcl-2↓, PI3K↓, JAK2↓, EMT↓, p27↑, ROCK1↓, MMP2↓, MMP9↓, NRF2↓, AntiTum↑, HO-1↓, NQO1↓, VEGF↓, MRP1/ABCC1↓, RadioS↑, PhotoS↑, toxicity↝,

5692-

BJ,

Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells

-

vitro+vivo,

AML,

NA

Apoptosis↑, Akt↓, P53↑, FOXO1↑, GSK‐3β↑, TumVol↓, QoL↑, BBB↑, OS↑, Dose↝, MMP↓, ROS↑, XIAP↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, TumCCA↑,

5481-

BM,

Therapeutic potential of Bacopa monnieri extracts against hepatocellular carcinoma through in-vitro and computational studies

-

in-vitro,

HCC,

HepG2

tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, lipid-P↓,

5486-

BM,

Bacopaside I, acting as an aquaporin 1 inhibitor, ameliorates rheumatoid arthritis via suppressing aquaporin 1-mediated autophagy

-

in-vivo,

Arthritis,

NA

rat adjuvant-induced arthritis (AIA)

*AQPs↓, TumCP↓, Apoptosis↑,

5477-

BM,

The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis.

-

in-vitro,

Var,

NA

AQPs↓, tumCV↓, Apoptosis↑, TumCMig↓,

5475-

BM,

The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis

-

in-vitro,

Colon,

HT29

-

in-vitro,

Colon,

SW48

-

in-vitro,

Colon,

SW-620

-

in-vitro,

CRC,

HCT116

AQPs↓, TumCG↓, TumCCA↓, Apoptosis↑, eff↝,

5684-

BML,

Bromelain mediates apoptosis in HeLa cells via ROS-independent pathway

-

in-vitro,

Cerv,

HeLa

 100 μg/ml after 48 h

ROS↑, Apoptosis↑, P53↑, TumCMig↓,

5680-

BML,

Anticancer properties of bromelain: State-of-the-art and recent trends

-

Review,

Var,

NA

*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1↑, IL2↓, IL4↓, IFN-γ↓, COX2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,

5678-

BML,

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy

-

in-vivo,

CRC,

NA

investigated using different CRC cell lines, a zebrafish model, and a xenograft mouse model.

AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, Endoglin↑, Casp3↑, Casp8↑, Casp9↑, ATG5↑, Beclin-1↑, p62↑, PARP↑,

5677-

BML,

Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis

-

in-vitro,

Melanoma,

A431

-

in-vitro,

Melanoma,

A375

TumCP↓, Inflam↓, Akt↓, NF-kB↓, COX2↓, GSH↓, ROS↑, MMP↓, TumCCA↑, Apoptosis↑, ChemoSen↑,

5651-

BNL,

Cisplatin,

Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway

-

in-vitro,

GBM,

U251

-

in-vitro,

GBM,

U87MG

ChemoSen↑, tumCV↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, ATR↑, ATM↑, P53↑, Histones↑, eff↓, Casp3↑, Casp7↑, Casp9↑,

5652-

BNL,

Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway

-

vitro+vivo,

GBM,

NA

SD rat brain glioma

Hif1a↓, Apoptosis↑, mTORC1↓, EIF4E↓, Bcl-2↓, BAX↑, Casp3↑, ChemoSen↑, ROS↑,

5653-

BNL,

Borneol hinders the proliferation and induces apoptosis through the suppression of reactive oxygen species-mediated JAK1 and STAT-3 signaling in human prostate cancer cells

-

in-vitro,

Pca,

PC3

(10, 20, 30 μM) for 24 hours

ROS↑, TumCP↓, cycD1/CCND1↓, cycE1↓, Apoptosis↑, BAX↓, Casp3↑, Bcl-2↓, IL6↓, JAK1↓, STAT3↓,

Showing Research Papers: 301 to 350 of 1398
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1398

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

4-HNE↑, 1, antiOx↑, 1, ATF3↓, 1, Catalase↓, 1, Ferroptosis↑, 1, GCLM↓, 1, GPx↑, 1, GSH↓, 2, GSH↑, 1, GSTA1↓, 1, GSTs↓, 1, HO-1↓, 2, HO-1↑, 1, lipid-P↓, 3, MDA↓, 1, MDA↑, 1, NQO1↓, 1, NRF2↓, 2, NRF2↑, 1, ROS↓, 1, ROS↑, 22, ROS∅, 1, i-ROS↑, 1, mt-ROS↑, 2, SOD↓, 1, SOD↑, 1, SOD2↓, 2,

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

AIF↑, 2, ATP↓, 1, CDC25↓, 1, ETC↓, 1, MMP↓, 14, mtDam↑, 2, OCR↓, 1, XIAP↓, 1, XIAP↑, 1,

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1, ACSL4↑, 1, AMPK↑, 1, CYP3A4↓, 1, GlucoseCon↓, 1, Histones↑, 1, LDL↓, 1, PPARγ↑, 1,

Cell Death ⓘ

Akt↓, 5, p‑Akt↓, 4, APAF1↑, 1, Apoptosis↓, 1, Apoptosis↑, 42, m-Apoptosis↑, 1, mt-Apoptosis↑, 4, BAD↑, 1, BAX↓, 1, BAX↑, 9, BAX↝, 2, Bax:Bcl2↑, 2, Bcl-2↓, 9, Bcl-2↑, 1, Bcl-2↝, 2, Casp↑, 4, Casp3↓, 1, Casp3↑, 14, Casp3↝, 1, cl‑Casp3↑, 3, proCasp3↑, 1, Casp7↑, 3, Casp8↑, 5, Casp9↑, 12, proCasp9↑, 1, Cyt‑c↓, 1, Cyt‑c↑, 8, Cyt‑c↝, 1, Diablo↑, 1, Fas↑, 1, Ferroptosis↑, 1, iNOS↓, 1, JNK↓, 2, JNK↑, 1, MAPK↓, 2, MAPK↑, 1, necrosis↑, 1, p27↑, 2, p38↑, 2, survivin↓, 2, TumCD↑, 2,

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 5,

Transcription & Epigenetics ⓘ

miR-21↓, 1, other↓, 1, PhotoS↑, 1, tumCV↓, 8,

Protein Folding & ER Stress ⓘ

HSP27↓, 2, HSP70/HSPA5⇅, 1,

Autophagy & Lysosomes ⓘ

ATG5↑, 2, Beclin-1↑, 2, LC3I↑, 1, p62↑, 1, TumAuto↑, 1,

DNA Damage & Repair ⓘ

ATM↑, 1, ATR↑, 1, CHK1↓, 1, DNAdam↑, 6, P53↓, 1, P53↑, 7, PARP↓, 1, PARP↑, 2, PARP↝, 1, cl‑PARP↑, 7, cl‑PARP1↑, 1, PCNA↓, 2, γH2AX↑, 1,

Cell Cycle & Senescence ⓘ

CDK2↓, 1, cycA1/CCNA1↓, 2, CycB/CCNB1↓, 2, cycD1/CCND1↓, 4, cycD1/CCND1↑, 1, cycD1/CCND1↝, 1, cycE1↓, 1, P21↓, 1, P21↑, 2, P21↝, 1, TumCCA↓, 2, TumCCA↑, 19,

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1, CSCs↓, 1, EIF4E↓, 1, EMT↓, 2, ERK↓, 1, FOXO1↑, 1, Gli1↓, 1, GSK‐3β↑, 1, mTOR↓, 3, mTORC1↓, 1, P70S6K↓, 1, PI3K↓, 3, p‑PI3K↓, 1, PTCH1↓, 1, STAT3↓, 3, p‑STAT3↓, 1, TOP1↓, 5, TOP2↓, 1, TumCG↓, 11,

Migration ⓘ

Ca+2↑, 1, GLI2↓, 1, Ki-67↓, 2, LAMs↓, 1, miR-221↓, 1, MMP2↓, 4, MMP9↓, 4, p44↓, 1, ROCK1↓, 1, Slug↓, 1, Snail↓, 1, TumCI↓, 6, TumCMig↓, 7, TumCP↓, 11, TumMeta↓, 2, β-catenin/ZEB1↓, 1,

Angiogenesis & Vasculature ⓘ

angioG↓, 2, EGFR↓, 4, Endoglin↑, 1, Hif1a↓, 1, VEGF↓, 6, p‑VEGFR2↓, 1,

Barriers & Transport ⓘ

AQPs↓, 2, BBB↑, 1, GLUT1↑, 1,

Immune & Inflammatory Signaling ⓘ

CCL20↑, 1, COX2↓, 2, COX2↝, 1, IFN-γ↓, 1, IL12↑, 1, IL2↓, 1, IL4↓, 1, IL6↓, 1, Imm↑, 1, Inflam↓, 1, JAK1↓, 2, JAK2↓, 2, NF-kB↓, 10, NF-kB↑, 1, p65↓, 1,

Protein Aggregation ⓘ

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, BioAv↑, 4, ChemoSen↑, 9, Dose↝, 3, eff↓, 6, eff↑, 3, eff↝, 2, MRP1/ABCC1↓, 1, RadioS↑, 5, selectivity↑, 7,

Clinical Biomarkers ⓘ

EGFR↓, 4, IL6↓, 1, Ki-67↓, 2,

Functional Outcomes ⓘ

AntiCan↑, 1, AntiTum↑, 4, chemoP↑, 1, chemoPv↑, 2, neuroP↑, 1, OS↑, 1, QoL↑, 1, toxicity↝, 1, TumVol↓, 3,
Total Targets: 205

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 1, NOX4↓, 1, ROS↓, 2,

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1, GlucoseCon↑, 1, Glycolysis↑, 1,

Cell Death ⓘ

Apoptosis↓, 2,

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Functional Outcomes ⓘ

hepatoP↑, 1, Pain↓, 1, Wound Healing↑, 1,

Infection & Microbiome ⓘ

Bacteria↓, 1, Diar↓, 1,
Total Targets: 15

Scientific Paper Hit Count for: Apoptosis, Apoptosis

68 Curcumin
67 Silver-NanoParticles
43 Magnetic Fields
41 Quercetin
36 Thymoquinone
34 Berberine
31 Sulforaphane (mainly Broccoli)
31 EGCG (Epigallocatechin Gallate)
29 Baicalein
25 Ashwagandha(Withaferin A)
25 Capsaicin
25 Shikonin
23 Betulinic acid
23 Phenethyl isothiocyanate
22 Resveratrol
20 Radiotherapy/Radiation
19 Artemisinin
19 Apigenin (mainly Parsley)
19 Boron
19 Chrysin
19 Selenite (Sodium)
18 Dandelion Root
18 Honokiol
18 Lycopene
18 Urolithin
17 Garcinol
16 Eugenol
15 Chemotherapy
15 Carvacrol
15 Nimbolide
14 Cisplatin
14 Astaxanthin
14 chitosan
14 Crocetin
14 Luteolin
13 Beta-Caryophyllene
13 salinomycin
13 Magnolol
12 Allicin (mainly Garlic)
12 Graviola
12 Selenium NanoParticles
11 Propolis -bee glue
11 Silymarin (Milk Thistle) silibinin
11 Gambogic Acid
10 Copper and Cu NanoParticles
10 Vitamin C (Ascorbic Acid)
10 Alpha-Lipoic-Acid
10 Metformin
10 Chlorogenic acid
10 Phenylbutyrate
10 Piperlongumine
9 α-Bisabolol / Chamomile oil
9 Selenium
9 Cucurbitacin
9 Fisetin
9 Juglone
9 Rosmarinic acid
8 Photodynamic Therapy
8 5-fluorouracil
8 Coenzyme Q10
8 Auranofin
8 Paclitaxel
8 Bufalin/Huachansu
8 Citric Acid
8 Carvone
8 Electrical Pulses
8 Ursolic acid
8 Dichloroacetate
8 Magnetic Field Rotating
7 Gemcitabine (Gemzar)
7 Atorvastatin
7 doxorubicin
7 Biochanin A
7 borneol
7 Boswellia (frankincense)
7 Caffeic acid
7 Carnosic acid
7 Cinnamon
7 Emodin
7 HydroxyTyrosol
7 Vitamin K2
6 Astragalus
6 Andrographis
6 Celecoxib
6 D-limonene
6 Ellagic acid
6 Hydrogen Gas
6 Piperine
6 Parthenolide
6 Terpinen-4-ol / Tea Tree Oil
5 Anethole/trans-Anethole
5 immunotherapy
5 Melatonin
5 Thymol-Thymus vulgaris
5 Celastrol
5 Chlorophyllin
5 Aflavin-3,3′-digallate
5 Genistein (soy isoflavone)
5 Plumbagin
5 Pterostilbene
4 1,8-Cineole
4 3-bromopyruvate
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Disulfiram
4 Eurycomanone
4 Ferulic acid
4 Ginkgo biloba
4 Geraniol
4 γ-linolenic acid (Borage Oil)
4 Linalool
4 Spermidine
3 2-DeoxyGlucose
3 tamoxifen
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Cat’s Claw
3 Cannabidiol
3 Cyclopamine
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Fennel Oil/Foeniculum vulgare
3 Galloflavin
3 Orlistat
3 Hyperthermia
3 Methyl salicylate / Sweet Birch oil
3 Magnesium
3 Naringin
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 α-Santalol/Sandalwood oil
3 Taurine
3 VitK3,menadione
3 Zerumbone
2 cetuximab
2 5-Aminolevulinic acid
2 Fenbendazole
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 DTS(dibenzyl trisulphide) from Anamu
2 Aspirin
2 Sorafenib (brand name Nexavar)
2 Dipyridamole
2 Aloe anthraquinones
2 beta-glucans
2 Docetaxel
2 Bortezomib
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Chocolate
2 irinotecan
2 CUSP9
2 Deguelin
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 Fucoidan
2 Shilajit/Fulvic Acid
2 Ginger/6-Shogaol/Gingerol
2 HydroxyCitric Acid
2 Methylglyoxal
2 Oleuropein
2 Oleocanthal
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Rutin
2 Sulfasalazine
2 polyethylene glycol
2 Vitamin D3
1 5-Hydroxytryptophan
1 Glucose
1 entinostat
1 Trichostatin A
1 Radio Frequency
1 Acetyl-l-carnitine
1 Amodiaquine
1 temozolomide
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Beta‐Lapachone
1 Selenate
1 Prebiotic
1 Choline
1 Hydroxycinnamic-acid
1 Vitamin E
1 Carica papaya leaf extract
1 Camptothecin
1 chemodynamic therapy
1 methylseleninic acid
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 Mistletoe
1 Lemongrass Extract/Citral
1 Evodiamine
1 Exercise
1 Gallic acid
1 carboplatin
1 gefitinib, erlotinib
1 Grapeseed extract
1 hydrogen sulfide
1 Rapamycin
1 Huperzine A/Huperzia serrata
1 Indole-3-carbinol
1 Inoscavin A
1 Ivermectin
1 Licorice
1 Lutein
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Lion’s Mane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Proanthocyanidins
1 isoflavones
1 Vorinostat
1 Oxaliplatin
1 Scoulerine
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Turmerones
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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