Hif1a Cancer Research Results

Hif1a, HIF1α/HIF1a: Click to Expand ⟱
Source:
Type:
Hypoxia-Inducible-Factor 1A (HIF1A gene, HIF1α, HIF-1α protein product)
-Dominantly expressed under hypoxia(low oxygen levels) in solid tumor cells
-HIF1A induces the expression of vascular endothelial growth factor (VEGF)
-High HIF-1α expression is associated with Poor prognosis
-Low HIF-1α expression is associated with Better prognosis

-Functionally, HIF-1α is reported to regulate glycolysis, whilst HIF-2α regulates genes associated with lipoprotein metabolism.
-Cancer cells produce HIF in response to hypoxia in order to generate more VEGF that promote angiogenesis

Key mediators of aerobic glycolysis regulated by HIF-1α.
-GLUT-1 → regulation of the flux of glucose into cells.
-HK2 → catalysis of the first step of glucose metabolism.
-PKM2 → regulation of rate-limiting step of glycolysis.
-Phosphorylation of PDH complex by PDK → blockage of OXPHOS and promotion of aerobic glycolysis.
-LDH (LDHA): Rapid ATP production, conversion of pyruvate to lactate;

HIF-1α Inhibitors:
-Curcumin: disruption of signaling pathways that stabilize HIF-1α (ie downregulate).
-Resveratrol: downregulate HIF-1α protein accumulation under hypoxic conditions.
-EGCG: modulation of upstream signaling pathways, leading to decreased HIF-1α activity.
-Emodin: reduce HIF-1α expression. (under hypoxia).
-Apigenin: inhibit HIF-1α accumulation.
Scientific Papers found: Click to Expand⟱
2621- Wog,    Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review
- Review, Var, NA
Hif1a↓, MCT4↓, LDH↓, lactateProd↓, ECAR↓, TumCP↓, Glycolysis↓,
961- Z,    Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo
- in-vitro, RCC, RCC4 - vitro+vivo, GBM, U373MG - in-vitro, Nor, HUVECs
Hif1a↓, HIF-1↓, VEGF↓, TumCI↓,

Showing Research Papers: 301 to 302 of 302
Prev Page 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 302

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

ECAR↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDH↓, 1,   MCT4↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

HIF-1↓, 1,   Hif1a↓, 2,   VEGF↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Hif1a, HIF1α/HIF1a
14 Apigenin (mainly Parsley)
14 Baicalein
14 Resveratrol
14 Sulforaphane (mainly Broccoli)
12 Silymarin (Milk Thistle) silibinin
10 EGCG (Epigallocatechin Gallate)
9 Vitamin C (Ascorbic Acid)
9 Berberine
9 Metformin
8 Curcumin
8 Shikonin
7 Honokiol
6 Thymoquinone
6 Alpha-Lipoic-Acid
6 Chrysin
6 Quercetin
5 Artemisinin
5 Radiotherapy/Radiation
5 Betulinic acid
5 Dichloroacetate
5 Magnetic Fields
5 Propolis -bee glue
5 Phenethyl isothiocyanate
4 Silver-NanoParticles
4 Ashwagandha(Withaferin A)
4 Chlorogenic acid
4 Deguelin
4 Ellagic acid
4 Graviola
4 Rosmarinic acid
4 Vitamin K2
3 Brucea javanica
3 brusatol
3 borneol
3 Boron
3 Capsaicin
3 Cinnamon
3 Citric Acid
3 Magnolol
2 5-fluorouracil
2 Allicin (mainly Garlic)
2 Caffeic acid
2 Carvacrol
2 Celastrol
2 Emodin
2 Electrical Pulses
2 Hydrogen Gas
2 HydroxyTyrosol
2 Luteolin
2 Lycopene
2 Melatonin
2 Oxygen, Hyperbaric
2 Proanthocyanidins
2 Piperlongumine
2 Sanguinarine
2 Wogonin
1 Coenzyme Q10
1 Auranofin
1 alpha Linolenic acid
1 Andrographis
1 Atorvastatin
1 tamoxifen
1 Baicalin
1 Biochanin A
1 Thymol-Thymus vulgaris
1 Sorafenib (brand name Nexavar)
1 Cannabidiol
1 Celecoxib
1 immunotherapy
1 Crocetin
1 Cucurbitacin
1 Bortezomib
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Fucoidan
1 Ferulic acid
1 Fenbendazole
1 Fisetin
1 Ai-Tong-An-Gao-Ji
1 Cisplatin
1 flavonoids
1 Gallic acid
1 Gambogic Acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Geraniol
1 γ-linolenic acid (Borage Oil)
1 HydroxyCitric Acid
1 Ivermectin
1 Juglone
1 Lactobacillus
1 mebendazole
1 metronomic chemo
1 Methylsulfonylmethane
1 Niclosamide (Niclocide)
1 Oroxylin-A
1 Oleuropein
1 doxorubicin
1 Rutin
1 salinomycin
1 Gemcitabine (Gemzar)
1 Salvia miltiorrhiza
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:143  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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