Hif1a Cancer Research Results

Hif1a, HIF1α/HIF1a: Click to Expand ⟱
Source:
Type:
Hypoxia-Inducible-Factor 1A (HIF1A gene, HIF1α, HIF-1α protein product)
-Dominantly expressed under hypoxia(low oxygen levels) in solid tumor cells
-HIF1A induces the expression of vascular endothelial growth factor (VEGF)
-High HIF-1α expression is associated with Poor prognosis
-Low HIF-1α expression is associated with Better prognosis

-Functionally, HIF-1α is reported to regulate glycolysis, whilst HIF-2α regulates genes associated with lipoprotein metabolism.
-Cancer cells produce HIF in response to hypoxia in order to generate more VEGF that promote angiogenesis

Key mediators of aerobic glycolysis regulated by HIF-1α.
-GLUT-1 → regulation of the flux of glucose into cells.
-HK2 → catalysis of the first step of glucose metabolism.
-PKM2 → regulation of rate-limiting step of glycolysis.
-Phosphorylation of PDH complex by PDK → blockage of OXPHOS and promotion of aerobic glycolysis.
-LDH (LDHA): Rapid ATP production, conversion of pyruvate to lactate;

HIF-1α Inhibitors:
-Curcumin: disruption of signaling pathways that stabilize HIF-1α (ie downregulate).
-Resveratrol: downregulate HIF-1α protein accumulation under hypoxic conditions.
-EGCG: modulation of upstream signaling pathways, leading to decreased HIF-1α activity.
-Emodin: reduce HIF-1α expression. (under hypoxia).
-Apigenin: inhibit HIF-1α accumulation.
Scientific Papers found: Click to Expand⟱
2446- SFN,  CAP,    The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor
- in-vitro, Pca, LNCaP
AR↓, Bcl-xL↓, TumCP↓, Glycolysis↓, HK2↓, PKA↓, Hif1a↓, PSA↓, ECAR↓, BioAv↑, BioAv↓, *toxicity↓,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
2556- SFN,    The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review
- Review, Var, NA
chemoPv↑, HDAC↓, Hif1a↓, angioG↓, CYP1A1↓, ChemoSen↑, BioAv↑,
1452- SFN,    Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-κB Signaling in Human Gastric Cancer Cells
- in-vitro, GC, AGS
MMP9↓, p38↓, ERK↓, AP-1↓, ROS↓, NF-kB↓, TumCI↓, MMP9↓, HDAC↓, Glycolysis↓, Hif1a↓, *memory↑, *cognitive↑,
1434- SFN,  GEM,    Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity
- in-vitro, CCA, HuCCT1 - in-vitro, CCA, HuH28 - in-vivo, NA, NA
HDAC↓, ac‑H3↑, ChemoSen↑, tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, TumCI↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, eNOS↓, EMT?, TumCG↓, Ki-67↓, TUNEL↑, P21↑, p‑Chk2↑, CDC25↓, BAX↑, *ROS↓, NQO1?,
1509- SFN,    Combination therapy in combating cancer
- Review, Var, NA
NRF2↑, ChemoSideEff↓, eff↑, TumCP↓, Apoptosis↑, TumCCA↑, ChemoSen↑, PSA↓, P53↑, Hif1a↓, CAIX/CA9↓, chemoR↓, 5HT↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, Synergy↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1484- SFN,    Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
- Review, Var, NA - Review, AD, NA
neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,
1732- SFN,    Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
- in-vitro, BC, MCF7 - in-vitro, BC, SUM159 - in-vivo, NA, NA
TumCD↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, *BioAv↑, angioG↓, VEGF↓, Hif1a↓, MMP2↓, MMP9↓, Casp3↑, *Half-Life∅,
1734- SFN,    Sulforaphane Inhibits Nonmuscle Invasive Bladder Cancer Cells Proliferation through Suppression of HIF-1α-Mediated Glycolysis in Hypoxia
- in-vitro, Bladder, RT112
selectivity↑, TumCP↓, Glycolysis↓, Hif1a↓,
1725- SFN,    Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway
- Review, Var, NA
*toxicity∅, AntiCan↑, antiOx↑, NRF2↑, DNMTs↓, HDAC↓, Hif1a↓, VEGF↓, P21↑, TumCCA↑, ac‑H3↑, ac‑H4↑, DNAdam↑, Dose↝,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2/PTGS2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP/DDIT3↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, Synergy↑, Synergy↑, Synergy↑, HER2/EBBR2↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, Synergy↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, Var, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3329- SIL,    Silymarin regulates the HIF-1 and iNOS expression in the brain and Gills of the hypoxic-reoxygenated rainbow trout (Oncorhynchus mykis)
- in-vivo, Nor, NA
*NO↓, *MDA↓, *TAC↑, *Hif1a↓, *iNOS↓,
3328- SIL,    Modulatory effect of silymarin on inflammatory mediators in experimentally induced benign prostatic hyperplasia: emphasis on PTEN, HIF-1α, and NF-κB
- in-vivo, BPH, NA
*NF-kB↓, *Hif1a↓, *PTEN↑, *Weight↓, *NO↓, *IL6↓, *IL8↓, *COX2/PTGS2↓, *iNOS↓,
3327- SIL,    Effects of silymarin on HIF‑1α and MDR1 expression in HepG‑2 cells under hypoxia
- in-vitro, Liver, HepG2
MDR1↓, Hif1a↓, P-gp/ABCB1↓,
3326- SIL,    Silymarin suppresses proliferation of human hepatocellular carcinoma cells under hypoxia through downregulation of the HIF-1α/VEGF pathway
- in-vitro, Liver, HepG2 - in-vitro, Liver, Hep3B
*hepatoP↑, chemoPv↑, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, Hif1a↓, VEGF↓, angioG↓,
3325- SIL,    Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury
- in-vivo, Nor, NA
*Inflam↓, *ROS↓, *Casp3↑, *Casp9↑, *Hif1a↓, *iNOS↓, *SOD↑, *MDA↓,
964- SIL,    Silibinin inhibits hypoxia-induced HIF-1α-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, 22Rv1
TumCP↓, Hif1a↓, NADPH↓, angioG↓, FASN↓, ACC↓,
1001- SIL,    Silibinin down-regulates PD-L1 expression in nasopharyngeal carcinoma by interfering with tumor cell glycolytic metabolism
- in-vitro, NPC, NA
TumCG↓, Glycolysis↓, OXPHOS↑, LDHA↓, lactateProd↓, i-citrate↑, Hif1a↓, PD-L1↓,
965- SK,    Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW-620
Hif1a↓, ROS↓, mTOR↓, p70S6↓, 4E-BP1↓, eIF2α↓, TumCCA↑, TumCP↓, Half-Life↝,
2370- SK,    The role of pyruvate kinase M2 in anticancer therapeutic treatments
- Review, Var, NA
Glycolysis↓, PKM2↓, EGFR↓, PI3K↓, p‑Akt↓, Hif1a↓,
2197- SK,    Shikonin derivatives for cancer prevention and therapy
- Review, Var, NA
ROS↑, Ca+2↑, BAX↑, Bcl-2↓, MMP9↓, NF-kB↓, PKM2↓, Hif1a↓, NRF2↓, P53↑, DNMT1↓, MDR1↓, COX2/PTGS2↓, VEGF↓, EMT↓, MMP7↓, MMP13↓, uPA↓, RIP1↑, RIP3↑, Casp3↑, Casp7↑, Casp9↑, P21↓, DFF45↓, TRAIL↑, PTEN↑, mTOR↓, AR↓, FAK↓, Src↓, Myc↓, RadioS↑,
2195- SK,    Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis
- in-vitro, OS, NA
TumCP↓, Ferroptosis↓, Hif1a↑, HO-1↑, Iron↑, ROS↑, GSH/GSSG↓, GPx4↓,
2194- SK,    Efficacy of Shikonin against Esophageal Cancer Cells and its possible mechanisms in vitro and in vivo
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, EC9706 - in-vivo, NA, NA
tumCV↓, TumCCA↑, Apoptosis↑, EGFR↓, PI3K↓, Hif1a↓, PKM2↓, cycD1/CCND1↓, AntiTum↑,
2193- SK,    Shikonin Suppresses Lymphangiogenesis via NF-κB/HIF-1α Axis Inhibition
- in-vitro, Nor, HMVEC-dLy
*NF-kB↓, *Hif1a↓, other↓,
3051- SK,    Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation
- Review, Var, NA
Nrf1↑, Apoptosis↑, TumCP↓, eff⇅, chemoP↑, eff↑, VCAM-1↓, Hif1a↓,
3041- SK,    Promising Nanomedicines of Shikonin for Cancer Therapy
- Review, Var, NA
Glycolysis↓, TAMS↝, BioAv↓, Half-Life↝, P21↑, ERK↓, ROS↑, GSH↓, MMP↓, TrxR↓, MMP13↓, MMP2↓, MMP9↓, SIRT2↑, Hif1a↓, PKM2↓, TumCP↓, TumMeta↓, TumCI↓,
1192- SM,    Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1
- in-vitro, GC, AGS - in-vitro, Liver, HepG3
Hif1a↓, VEGF↓,
1688- SSE,    Potential Role of Selenium in the Treatment of Cancer and Viral Infections
- Review, Var, NA
IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, Synergy↑,
5331- TFdiG,    Anti-Cancer Properties of Theaflavins
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑Akt↓, p‑mTOR↓, PI3K↓, cMyc↓, P53↑, ROS↑, NF-kB↓, MMP9↓, MMP2↓, TumVol↓, PSA↓, TumCCA↑, VEGF↓, Hif1a↓, CDK2↓, CDK4↓, GSH↓, Dose↑, BioAv↓, BioAv↓, BioAv↑,
962- TQ,    Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways
- in-vitro, PC, PANC1 - in-vitro, Nor, hTERT-HPNE - in-vitro, PC, AsPC-1 - in-vitro, PC, Bxpc-3
TumCMig↓, TumCI↓, Apoptosis↑, Hif1a↓, PI3k/Akt/mTOR↓, TumCCA↑, *toxicity↓, *TumCI∅, *TumCMig∅,
2125- TQ,    Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis
- in-vitro, RCC, RCC4 - in-vitro, RCC, Caki-1
Hif1a↓, eff↝, uPAR↓, VEGF↓, CAIX/CA9↓, PDK1 / PDPK1↓, GLUT1↓, LDHA↓, Glycolysis↓, e-lactateProd↓, i-ATP↓,
2138- TQ,    Thymoquinone has a synergistic effect with PHD inhibitors to ameliorate ischemic brain damage in mice
- in-vivo, Nor, NA
*Hif1a↑, *VEGF↑, *TrkB↑, *PI3K↑, *angioG↑, *neuroG↑, *motorD↑,
2139- TQ,    Thymoquinone regulates microglial M1/M2 polarization after cerebral ischemia-reperfusion injury via the TLR4 signaling pathway
- in-vivo, Nor, NA
*TLR4↓, *NF-kB↓, *Inflam↓, *Hif1a↑, *motorD↑,
3431- TQ,    PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Glycolysis↓, Warburg↓, HK2↓, ATP↓, NADPH↓, PI3K↓, Akt↓, TumCP↓, E-cadherin↑, N-cadherin↓, Hif1a↓, PKM2↓, GlucoseCon↓, lactateProd↓, EMT↓,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
1067- VitC,    Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer
- in-vivo, CRC, NA
PDK1 / PDPK1↓, Hif1a↓, GLUT1↓, ATP↓, MMP↓,
596- VitC,    High-Dose Vitamin C in Advanced-Stage Cancer Patients
- Review, Var, NA
ChemoSideEff↓, ROS↑, H2O2↑, Fenton↑, Hif1a↝, Dose↑, BioAv↓, Dose↝, Half-Life↝, IL1β↓, IL2↓, IL8↓, TNF-α↓,
632- VitC,    High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients
- Review, Var, NA
SVCT-2∅, ROS↑, Hif1a↓, PARP∅, TET2↑,
3146- VitC,    Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes
- in-vivo, Nor, NA
*Obesity↓, *ER Stress↓, *Inflam↓, Hif1a↓, VEGF↓, GLUT1↓, GRP78/BiP↓,
3114- VitC,    Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
- in-vitro, AML, NA
TET2↑, eff↑, ROS↑, Fenton↑, Hif1a↓,
3115- VitC,    The NF-κB Transcriptional Network Is a High-Dose Vitamin C-Targetable Vulnerability in Breast Cancer
- in-vitro, BC, NA
NF-kB↓, Hif1a↓, P53↑,
3107- VitC,    Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment
- Review, Var, NA
Risk↓, *ROS↓, ROS↑, VEGF↓, COX2/PTGS2↓, ER Stress↑, IRE1↑, JNK↑, CHOP/DDIT3↑, Hif1a↓, Synergy↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, Synergy↑, TET1↑,
1219- VitC,    Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells
- in-vitro, Melanoma, NA
Hif1a↓,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,

Showing Research Papers: 301 to 350 of 359
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 359

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 7,   antiOx⇅, 1,   Catalase↓, 4,   Catalase↑, 3,   Fenton↑, 3,   frataxin↑, 1,   GPx↓, 1,   GPx↑, 4,   GPx4↓, 3,   GPx4↑, 1,   GSH↓, 12,   GSH↑, 5,   GSH/GSSG↓, 1,   GSTs↑, 2,   H2O2↓, 3,   H2O2↑, 4,   HO-1↓, 7,   HO-1↑, 9,   HO-2↓, 1,   Iron↑, 3,   Iron∅, 1,   lipid-P↓, 3,   lipid-P↑, 8,   MDA?, 1,   MDA↓, 1,   MDA↑, 3,   MPO↓, 3,   NADH↓, 1,   NADPH/NADP+↓, 1,   NOX4↑, 1,   NQO1?, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↓, 16,   NRF2↑, 21,   p‑NRF2↓, 1,   p‑NRF2↑, 1,   Prx↓, 1,   PrxI↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 19,   ROS↑, 127,   ROS⇅, 4,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↓, 1,   mt-ROS↑, 2,   RPM↑, 1,   SOD↓, 5,   SOD↑, 5,   SOD2↓, 2,   SOD2↑, 1,   TAC↓, 1,   TKT↝, 1,   Trx↓, 1,   ox-Trx1↑, 1,   TrxR↓, 5,   TrxR1↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 1,   NCOA4↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   BCR-ABL↓, 1,   CDC2↓, 1,   CDC25↓, 2,   compI↓, 1,   EGF↓, 1,   ETC↓, 3,   ETC↝, 1,   MCU↓, 1,   mitResp↓, 4,   MKK7↓, 1,   Mortalin↓, 1,   mtDam↑, 8,   OCR↓, 6,   OCR↑, 4,   OXPHOS↓, 1,   OXPHOS↑, 7,   mt-OXPHOS↓, 2,   PDH↓, 3,   PDH↑, 5,   PDH↝, 1,   PGC-1α↑, 1,   SDH↓, 1,   SIRT3↓, 2,   SIRT3↑, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   AApath↓, 1,   ACC↓, 2,   ACLY↓, 1,   Alanine↓, 1,   ALAT↓, 1,   ALAT↝, 1,   ALDOA↓, 1,   AMACR↓, 1,   AMP↓, 1,   AMPK↑, 18,   p‑AMPK↑, 3,   p‑AMT/GCST/T-protein↑, 1,   ATP↓, 21,   ATP↑, 2,   ATP↝, 1,   i-ATP↓, 1,   CAIX/CA9↓, 2,   CAIX/CA9↑, 1,   citrate↓, 2,   i-citrate↑, 1,   CPT1A↓, 1,   ECAR↓, 8,   ECAR↝, 1,   ENO1↓, 2,   FASN↓, 7,   FASN↑, 1,   FDG↓, 1,   G6PD↓, 5,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↓, 3,   glucoNG↓, 1,   GlucoseCon↓, 24,   GlucoseCon↑, 3,   glut↓, 1,   GlutaM↓, 1,   GlutMet↓, 2,   Glycine↓, 1,   Glycolysis↓, 75,   Glycolysis↑, 3,   GPI↓, 1,   GSK‐3β↓, 5,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 5,   HAGH/GLO2↓, 1,   HK1↓, 1,   HK2↓, 34,   HK2↑, 2,   HMG-CoA↓, 2,   IDH1↑, 1,   lact/pyru↓, 1,   lactateProd↓, 22,   lactateProd↑, 4,   e-lactateProd↓, 1,   LAR↓, 1,   LDHA↓, 26,   LDHA↑, 1,   LDL↓, 1,   lipoGen↓, 1,   MCT4↓, 1,   NADPH↓, 4,   NADPH↑, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 19,   p‑PDK1 / PDPK1↓, 1,   PDK3↓, 1,   PDKs↓, 2,   PFK↓, 5,   PFK1↓, 3,   PFK1↑, 1,   PFK2?, 1,   PFKP?, 1,   PFKP↓, 1,   PKM2↓, 39,   PKM2:PKM1↓, 1,   PPP↓, 1,   Pyruv↓, 2,   R5P↝, 1,   p‑S6↓, 2,   SCD1↓, 2,   SHARP↑, 1,   SIRT1↓, 4,   SIRT1↑, 8,   SIRT2↓, 1,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   TCA↓, 3,   TCA↑, 1,   TPI↓, 1,   Warburg↓, 14,   Warburg↑, 1,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 5,   Apoptosis?, 1,   Apoptosis↓, 5,   Apoptosis↑, 101,   mt-Apoptosis↑, 1,   ASK1↑, 1,   aSmase↝, 1,   BAD↓, 1,   BAD↑, 5,   Bak↑, 5,   BAX↓, 2,   BAX↑, 51,   BAX⇅, 1,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 12,   Bcl-2↓, 56,   Bcl-2↑, 2,   Bcl-xL↓, 20,   BID↓, 1,   BID↑, 2,   BIM↓, 1,   BIM↑, 2,   BNIP3↑, 1,   BNIP3↝, 1,   BOK↑, 1,   Casp↑, 13,   Casp↝, 1,   Casp∅, 1,   cl‑Casp↑, 1,   Casp1↑, 1,   Casp12?, 1,   Casp12↑, 2,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 80,   cl‑Casp3↑, 8,   proCasp3↑, 2,   Casp6↑, 1,   Casp7↑, 8,   cl‑Casp7↑, 3,   Casp8↑, 8,   cl‑Casp8↑, 3,   pro‑Casp8↑, 1,   Casp9↑, 45,   cl‑Casp9↑, 5,   cFLIP↓, 5,   CSR1↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 44,   Diablo↑, 5,   DR5↑, 12,   FADD↑, 3,   Fas↓, 1,   Fas↑, 11,   FasL↑, 3,   Ferroptosis↓, 1,   Ferroptosis↑, 10,   GSDME↑, 1,   HEY1↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 12,   JWA↑, 1,   Mcl-1?, 1,   Mcl-1↓, 18,   Mcl-1↑, 1,   MDM2↓, 3,   MDM2↑, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 1,   necrosis↑, 2,   NOXA↑, 1,   oncosis↑, 1,   p38↓, 3,   p38↑, 4,   p‑p38↓, 1,   PUMA↑, 3,   Pyro↑, 1,   RIP1↑, 1,   RIP3↑, 1,   survivin↓, 25,   TNFR 1↑, 1,   TRAIL↑, 3,   TumCD↑, 5,   TUNEL↑, 1,   XIAP↓, 14,   XIAP↝, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 82,   Akt↑, 7,   Akt↝, 1,   Akt∅, 1,   p‑Akt↓, 30,   p‑Akt↑, 2,   AKT1↓, 2,   Akt2↓, 1,   AMPKα↑, 2,   Brk/PTK6↓, 1,   CaMKII ↓, 1,   CIP2A↓, 1,   CK2↓, 5,   cMET↓, 2,   p‑cMET↑, 1,   DDIT4?, 1,   EF-1α↓, 1,   EGFR↓, 29,   EphB4↓, 2,   ERK↓, 29,   ERK↑, 2,   ERK↝, 1,   ERK∅, 1,   p‑ERK↓, 10,   p‑ERK↑, 1,   FLT4↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 7,   HGF/c-Met↓, 1,   HRAS↓, 1,   IGF-1R↓, 5,   IKKα↓, 5,   p‑IKKα↓, 1,   ILK↓, 1,   IκB↓, 1,   JAK↓, 3,   p‑JAK1↓, 1,   JAK2↓, 4,   p‑JAK2↓, 1,   JNK↓, 2,   JNK↑, 12,   p‑JNK↓, 2,   MAPK↓, 19,   MAPK↑, 3,   MAPK↝, 1,   MARK4↓, 1,   MEK↓, 4,   MKK4↓, 1,   mTOR↓, 50,   p‑mTOR↓, 11,   p70S6↓, 2,   p‑p70S6↓, 2,   P70S6K↓, 3,   P70S6K↑, 1,   p‑P70S6K↓, 3,   P90RSK↓, 1,   p‑P90RSK↑, 1,   PAK↓, 1,   PDGFRB↓, 1,   PFKFB2↓, 1,   PI3K↓, 65,   PI3K↑, 3,   PI3K↝, 1,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 2,   p‑PI3k/Akt/mTOR↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 9,   PKCδ↑, 1,   PP2A↑, 1,   PRAS40↑, 1,   PTEN↓, 1,   PTEN↑, 22,   Raf↓, 3,   c-Raf↓, 1,   RAS↓, 1,   p‑S6K↓, 2,   Sp1/3/4↓, 8,   Src↓, 1,   STAT↓, 2,   STAT3↓, 55,   p‑STAT3↓, 6,   p‑STAT3↑, 1,   STAT5↓, 1,   THEM4/CTMP↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ARNT?, 1,   ATF3↑, 1,   ATF4↑, 3,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 27,   DNMT1↓, 5,   DNMT3A↓, 1,   DNMTs↓, 7,   EZH2↓, 3,   FOXM1↓, 2,   FOXO↑, 2,   FOXO3↓, 3,   FOXO3↑, 3,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 1,   H3↑, 1,   ac‑H3↑, 3,   H4↑, 1,   ac‑H4↑, 2,   HATs↓, 2,   HATs↑, 3,   HDAC↓, 22,   HDAC1↓, 2,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC4↓, 2,   HDAC8↓, 1,   HES1↓, 2,   miR-122-5p↑, 1,   miR-124-3p↓, 1,   miR-126↑, 1,   miR-155↓, 2,   miR-195↑, 1,   miR-199↑, 1,   miR-203↓, 1,   miR-203↑, 1,   miR-206↑, 1,   miR-21↓, 3,   miR-21↑, 1,   miR-210↓, 1,   miR-210↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-27a-3p↓, 1,   miR-29b↓, 1,   miR-30a-5p↑, 1,   miR-326-5p↑, 1,   miR-339-5p↝, 1,   miR-34a↑, 1,   miR-34b-5p↑, 2,   miR-375↑, 1,   miR-384↑, 1,   miR-590-3p↑, 1,   Myc↓, 4,   n-MYC↓, 1,   OCT4↓, 4,   other↓, 2,   other↑, 1,   other↝, 6,   SOX2↓, 4,   SOX4↓, 1,   SOX9?, 1,   SPP1↓, 1,   SUV39H↓, 3,   TFAP2A↓, 1,   tumCV?, 1,   tumCV↓, 17,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 11,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 2,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 22,   GRP78/BiP↓, 1,   GRP78/BiP↑, 8,   Hsc70↓, 1,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 1,   HSP90↓, 15,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 1,   PERK↑, 4,   UPR↑, 5,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ATG3↑, 1,   ATG5↑, 2,   ATG5↝, 1,   ATG7↑, 2,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 6,   Beclin-1/ATG6↝, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 3,   LC3B-II↑, 1,   LC3II↓, 1,   LC3II↑, 6,   LC3s↑, 1,   p62↓, 4,   p62↑, 2,   RUBCN↓, 1,   TumAuto↓, 1,   TumAuto↑, 21,   TumAuto↝, 1,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↓, 1,   BRCA1↝, 1,   DFF45↓, 1,   DNA-PK↓, 1,   DNAdam↓, 3,   DNAdam↑, 29,   DNArepair↓, 3,   DNArepair↑, 1,   ERCC1↓, 1,   ERCC4/XPF↓, 1,   m-FAM72A↓, 1,   HR↓, 1,   hTERT/TERT↓, 7,   importin α/β↓, 1,   Ku70/XRCC6↓, 1,   MGMT↓, 1,   p16↑, 3,   P53?, 2,   P53↓, 3,   P53↑, 50,   P53↝, 1,   P53∅, 1,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↓, 1,   PARP↑, 8,   PARP∅, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 29,   PARP1↓, 1,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 18,   POLD1↓, 1,   RAD51↓, 1,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 16,   TOP1↓, 5,   TOP2↓, 4,   TP53↑, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK1/2/5/9↓, 1,   CDK2↓, 18,   CDK2↑, 1,   CDK4↓, 23,   CDK4/6↓, 1,   CDK6↓, 11,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   Chk2↓, 1,   p‑Chk2↑, 2,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 11,   cycD1/CCND1↓, 43,   CycD3↓, 1,   cycE/CCNE↓, 8,   cycE/CCNE↑, 2,   cycE1↓, 2,   E2Fs↑, 1,   Ki-67↓, 11,   MAD↓, 1,   mitA↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 35,   p27/CDKN1B↑, 17,   pRB↑, 1,   p‑pRB↓, 2,   RB1↑, 1,   p‑RB1↓, 3,   TumCCA↓, 4,   TumCCA↑, 88,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 3,   p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 1,   AXIN1↑, 1,   BMPs↑, 1,   CD133↓, 5,   CD24↓, 2,   CD34↓, 1,   cFos↓, 1,   cMYB↓, 2,   CSCs?, 1,   CSCs↓, 24,   Diff↓, 1,   EIF4E↓, 3,   FBXW7↝, 1,   FGF↓, 1,   FGF↑, 1,   Gli↓, 1,   Gli1↓, 7,   HH↓, 3,   IGF-1↓, 10,   IGFBP1↑, 1,   IGFBP3↑, 2,   Ki-67↓, 11,   Let-7↑, 1,   MCM2↓, 1,   mTORC1↓, 8,   p‑mTORC1↓, 1,   Nanog↓, 4,   Nestin↓, 3,   NOTCH↓, 11,   NOTCH1↓, 4,   NOTCH1↑, 1,   NOTCH1↝, 1,   NOTCH3↓, 2,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 6,   Smo↓, 5,   TumCG?, 1,   TumCG↓, 47,   TumCG↑, 2,   TumCP↓, 83,   TumCP↑, 3,   Wnt↓, 14,   Wnt/(β-catenin)↓, 8,  

Migration(tgid=13) ⓘ

annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 6,   AP-1↝, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 4,   Ca+2↑, 16,   Ca+2↝, 1,   CAFs/TAFs↓, 1,   CAFs/TAFs↝, 1,   cal2↑, 1,   CD11b↓, 1,   COL4A3↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 28,   EMT?, 1,   EMT↓, 50,   EMT↝, 1,   FAK↓, 10,   p‑FAK↓, 3,   Fibronectin↓, 2,   GLI2↓, 2,   GnT-V↝, 1,   heparanase↝, 1,   ITGA2↓, 1,   ITGA5↓, 1,   ITGA6↓, 1,   ITGB1↓, 4,   ITGB1↑, 1,   ITGB3↓, 3,   ITGB4↓, 2,   ITGB6↓, 1,   LAMs↓, 2,   MALAT1↓, 3,   MMP-10↓, 2,   MMP1↓, 2,   MMP13↓, 3,   MMP16↓, 1,   MMP2↓, 54,   MMP3↓, 4,   MMP7↓, 5,   MMP9↓, 61,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 24,   MUC4↓, 2,   N-cadherin↓, 18,   NCAM↑, 1,   NM23↑, 1,   PAK1↓, 1,   PDGF↓, 6,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 4,   ROCK1↑, 1,   Slug↓, 4,   SMAD2↓, 2,   p‑SMAD2↓, 1,   SMAD3↓, 4,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 19,   talin↓, 1,   TET1↑, 2,   TGF-β↓, 12,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 5,   TIMP2↓, 1,   TIMP2↑, 3,   TSC1↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 56,   TumCMig↓, 50,   TumMeta↓, 39,   TumMeta↑, 3,   Twist↓, 10,   uPA↓, 12,   uPAR↓, 1,   Vim?, 1,   Vim↓, 24,   Zeb1↓, 7,   ZEB2↓, 1,   α-SMA↓, 2,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 24,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 86,   angioG↑, 1,   CD31/PECAM-1↓, 6,   CD31/PECAM-1↑, 1,   Endoglin↑, 1,   eNOS↓, 2,   HIF-1↓, 2,   Hif1a↓, 314,   Hif1a↑, 12,   Hif1a↝, 4,   HIF2a↓, 1,   Hypoxia↑, 1,   LOX1↓, 2,   NO↓, 4,   NO↑, 2,   PHDs↑, 1,   TYMP/ECGF1↓, 1,   VCAM-1↓, 3,   VEGF↓, 142,   VEGF↑, 2,   VEGFR1↓, 3,   VEGFR2/KDR/Flk1↓, 17,   VHL↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   CLDN1↓, 1,   CLDN2↓, 1,   CTR1↑, 1,   EPR↑, 2,   EPR↝, 1,   GLUT1↓, 41,   GLUT1↑, 3,   GLUT2↓, 1,   GLUT3↓, 3,   GLUT3↑, 1,   GLUT4↓, 4,   MMP↓, 50,   MMP↑, 2,   MPT↑, 2,   NHE1↓, 3,   SVCT-2∅, 1,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ALC∅, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 1,   CD44↓, 8,   CD47↓, 1,   CD8+↑, 3,   COX1↓, 1,   COX2/PTGS2↓, 44,   COX2/PTGS2↑, 3,   CXCL12↓, 3,   CXCL6/GCP-2↓, 1,   CXCR4↓, 8,   DR4↑, 3,   FOXP3↓, 1,   Gal-3↓, 2,   HCAR1↓, 1,   HMGB1↓, 3,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 3,   Igs↑, 1,   IL1↓, 5,   IL1↑, 1,   IL10↓, 5,   IL10↑, 2,   IL12↓, 2,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 3,   IL4↓, 1,   IL4↑, 1,   IL6↓, 27,   IL8↓, 7,   IL8↑, 1,   Imm↑, 5,   Imm↝, 1,   INF-γ↑, 1,   Inflam↓, 11,   M2 MC↓, 1,   pol-M2 MC↓, 1,   MCP1/CCL2↓, 1,   MCT1↓, 2,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 82,   NF-kB↑, 2,   p‑NF-kB↓, 1,   NK cell↑, 5,   NLRP3↓, 2,   p50↓, 1,   p65↓, 3,   PD-1↓, 3,   PD-L1↓, 7,   PGE2↓, 10,   PSA↓, 7,   PSA∅, 1,   RAGE↑, 1,   T-Cell↑, 2,   T-Cell↝, 1,   TCF↓, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 3,   TNF-α↓, 16,   TNF-α↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,   pH↝, 1,   e-pH↑, 1,   i-pH↓, 1,   PLC↓, 1,   TAMS↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↑, 1,   Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AR↓, 8,   ARNT?, 1,   CYP19↓, 1,   ER(estro)↓, 2,   Estro↝, 1,   GR↑, 1,   PPARα↓, 1,   PPARα↝, 1,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 5,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 27,   BioAv↑, 21,   BioAv↝, 4,   BioEnh↑, 5,   chemoR↓, 1,   ChemoSen↑, 85,   ChemoSen⇅, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 4,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   Dose?, 3,   Dose↓, 4,   Dose↑, 9,   Dose↝, 31,   Dose∅, 10,   eff↓, 22,   eff↑, 46,   eff⇅, 1,   eff↝, 12,   eff∅, 1,   GSTZ1↓, 1,   Half-Life↓, 7,   Half-Life↑, 1,   Half-Life↝, 7,   Half-Life∅, 1,   MDR1↓, 4,   P-gp/ABCB1↓, 7,   P-gp/ABCB1↑, 1,   P450↓, 4,   RadioS↑, 34,   selectivity↑, 35,   Synergy↑, 65,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↑, 1,   ALAT↓, 1,   ALAT↝, 1,   ALP↓, 1,   ALP↝, 1,   AR↓, 8,   ascitic↓, 1,   AST↝, 1,   BRCA1↓, 1,   BRCA1↝, 1,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 29,   EZH2↓, 3,   FOXM1↓, 2,   HEC1↓, 1,   HER2/EBBR2↓, 7,   hTERT/TERT↓, 7,   IL6↓, 27,   LDH↓, 9,   LDH↑, 1,   Myc↓, 4,   NOS2↓, 1,   PD-L1↓, 7,   PSA↓, 7,   PSA∅, 1,   RAGE↑, 1,   TP53↑, 2,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 28,   AntiCan∅, 2,   AntiTum↑, 7,   cachexia↓, 1,   cardioP↑, 6,   CardioT↓, 1,   chemoP↓, 1,   chemoP↑, 17,   chemoPv↑, 15,   ChemoSideEff↓, 9,   fatigue↓, 3,   hepatoP↑, 6,   IMPDH1↓, 1,   IMPDH2↓, 1,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 5,   NP/CIPN↓, 2,   OS↑, 12,   PFS↑, 2,   QoL↑, 4,   radioP↑, 5,   RenoP↑, 2,   Risk↓, 6,   Risk↑, 1,   Sleep↑, 1,   toxicity↓, 13,   toxicity↝, 5,   toxicity∅, 2,   TumVol↓, 15,   TumW↓, 12,   Weight∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 3,   GutMicro↝, 1,  
Total Targets: 942

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 30,   Catalase↓, 1,   Catalase↑, 15,   GPx↑, 12,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 14,   GSR↑, 1,   GSTs↑, 5,   H2O2↓, 1,   HO-1↓, 2,   HO-1↑, 9,   Iron↓, 2,   Keap1↓, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 7,   MDA↓, 12,   MDA↑, 1,   MPO↓, 3,   NOX4↓, 1,   NRF2↑, 24,   RNS↓, 1,   ROS↓, 61,   ROS↑, 1,   mt-ROS?, 1,   mt-ROS↑, 1,   SOD↓, 1,   SOD↑, 20,   SOD1↑, 2,   SOD2↑, 2,   TAC↑, 2,   TBARS↓, 2,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↓, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   Insulin↑, 2,   MFN2↑, 1,   mtDam↓, 1,   OXPHOS↑, 1,   PDH↑, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ALAT↓, 5,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP↑, 4,   ECAR↓, 1,   glucose↓, 4,   GlucoseCon↑, 4,   Glycolysis↓, 2,   Glycolysis↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   H2S↑, 1,   HK1↑, 1,   HK2↓, 2,   lactateProd↓, 2,   LDHA↑, 1,   LDL↓, 2,   lipidLev↓, 1,   NADPH↑, 1,   p‑PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 4,   PPP↓, 1,   SIRT1↑, 6,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 3,   BAX↓, 1,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 4,   Casp3↑, 1,   Casp9↓, 1,   Casp9↑, 1,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 12,   p38↓, 2,   Pyro↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 4,   p‑Akt↓, 1,   ERK↓, 1,   IGF-1R↓, 1,   IκB?, 1,   JAK↓, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 3,   mTOR↓, 2,   mTOR↑, 1,   p‑P70S6K↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 6,   PI3K↑, 3,   PKCδ↓, 1,   PKCδ↑, 1,   PTEN↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ARNT↑, 1,   ATF2↑, 1,   ATF4↓, 2,   FOXO1↑, 1,   FOXO3↑, 2,   HDAC↓, 1,   other↓, 3,   other↑, 6,   other↝, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   cl‑eIF2α↑, 1,   ER Stress↓, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 1,   PERK↓, 1,   p‑PERK↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNArepair↑, 1,   P53↓, 1,   PARP1↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 2,   GADD45A↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↑, 1,   FGF↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Jun↑, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 1,   Ca+2↓, 2,   EMT↓, 1,   ITGB1↑, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP9↓, 1,   MMP9↑, 1,   NFAM1↑, 1,   NFAT↑, 2,   Rho↓, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TumCI∅, 1,   TumCMig∅, 1,   Vim↓, 1,   α-SMA↓, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 5,   Hif1a↓, 19,   Hif1a↑, 14,   Hif1a↝, 1,   Hif1a∅, 2,   NO↓, 8,   NO↑, 1,   REL↑, 1,   VCAM-1↓, 3,   VEGF↓, 3,   VEGF↑, 7,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 7,   GLUT1↓, 1,   GLUT3↑, 2,   GLUT4↑, 3,   H+/K+-ATPase↓, 1,   IBI↑, 1,   MMP↓, 1,   MMP↑, 5,   TRPC1↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 15,   COX2/PTGS2↑, 1,   CXCc↑, 1,   CXCR2↑, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↓, 1,   IL10↑, 2,   IL17↓, 1,   IL18↓, 2,   IL1β↓, 5,   IL2↑, 1,   IL4↓, 1,   IL6↓, 10,   IL6↑, 1,   IL8↓, 4,   Imm↑, 3,   Inflam↓, 46,   LIF↑, 1,   LPS↓, 1,   pol-M2 MC↑, 1,   MyD88↓, 1,   NF-kB↓, 20,   NF-kB↑, 1,   NLRP3↓, 3,   OSM↑, 1,   PGE2↓, 4,   TLR4↓, 3,   TNF-α↓, 8,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 1,   AChE↓, 5,   AChE↑, 1,   BDNF↑, 2,   ChAT↑, 1,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 5,   BACE/β-secretase↓, 2,   tau↓, 3,   p‑tau↓, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AhR↑, 1,   ARNT↑, 1,   CYP19↓, 1,   PPARα↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 23,   BioAv↑, 13,   BioAv↝, 7,   BioAv∅, 1,   Dose⇅, 1,   Dose↝, 7,   Dose∅, 1,   eff↓, 1,   eff↑, 4,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↓, 1,   Half-Life↝, 4,   Half-Life∅, 4,   P450↑, 1,   selectivity↑, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 1,   AST↓, 7,   BG↓, 1,   BMD↑, 1,   BP↓, 3,   creat↓, 2,   CRP↓, 1,   IL6↓, 10,   IL6↑, 1,   IRes↝, 1,   LDH↓, 4,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 5,   antiAll↑, 5,   AntiCan↓, 1,   AntiCan↑, 5,   AntiDiabetic↑, 8,   antiPs↑, 3,   AntiTum↑, 1,   cardioP?, 1,   cardioP↑, 16,   cardioP⇅, 1,   CardioT↓, 1,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↑, 9,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 18,   memory↑, 11,   motorD↓, 1,   motorD↑, 3,   neuroP↓, 1,   neuroP↑, 34,   Obesity↓, 7,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 7,   Stroke↓, 5,   toxicity↓, 19,   toxicity↑, 2,   toxicity↝, 4,   toxicity∅, 6,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiViral↑, 2,   Bacteria↓, 7,   GutMicro↑, 7,   Sepsis↓, 1,  
Total Targets: 324

Scientific Paper Hit Count for: Hif1a, HIF1α/HIF1a
14 Apigenin (mainly Parsley)
14 Baicalein
14 Resveratrol
14 Sulforaphane (mainly Broccoli)
12 Silymarin (Milk Thistle) silibinin
10 EGCG (Epigallocatechin Gallate)
9 Vitamin C (Ascorbic Acid)
9 Berberine
9 Metformin
8 Curcumin
8 Melatonin
8 Shikonin
7 Honokiol
6 Thymoquinone
6 Alpha-Lipoic-Acid
6 Chrysin
6 Quercetin
5 Silver-NanoParticles
5 Artemisinin
5 Radiotherapy/Radiation
5 Betulinic acid
5 Dichloroacetate
5 Magnetic Fields
5 Propolis -bee glue
5 Phenethyl isothiocyanate
4 Ashwagandha(Withaferin A)
4 Chlorogenic acid
4 Deguelin
4 Ellagic acid
4 Emodin
4 Graviola
4 Vitexin
4 Rosmarinic acid
4 Vitamin K2
3 Brucea javanica
3 brusatol
3 borneol
3 Boron
3 Capsaicin
3 chaetocin
3 Cinnamon
3 Citric Acid
3 Formononetin
3 Hydrogen Gas
3 HydroxyTyrosol
3 Isoliquiritigenin
3 Kaempferol
3 Licochalcone A
3 Licorice
3 Luteolin
3 Magnolol
3 MCT, metronomic chemo
3 methylseleninic acid
2 5-fluorouracil
2 Allicin (mainly Garlic)
2 Caffeic acid
2 Carvacrol
2 Celastrol
2 Electrical Pulses
2 Cisplatin
2 Fucoidan
2 Gambogic Acid
2 Isovitexin
2 Lutein
2 Lycopene
2 mebendazole
2 Modified Citrus Pectin
2 Oxygen, Hyperbaric
2 Proanthocyanidins
2 Piperlongumine
2 Sanguinarine
2 Wogonin
1 Coenzyme Q10
1 Annona atemoya Seed Extract
1 Auranofin
1 alpha Linolenic acid
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Atorvastatin
1 tamoxifen
1 Baicalin
1 Biochanin A
1 Thymol-Thymus vulgaris
1 Sorafenib (brand name Nexavar)
1 Cannabidiol
1 Celecoxib
1 immunotherapy
1 Crocetin
1 Cucurbitacin
1 Bortezomib
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Diindolylmethane
1 Ormeloxifene (Centchroman)
1 Ferulic acid
1 Fenbendazole
1 Fisetin
1 Ai-Tong-An-Gao-Ji
1 flavonoids
1 Gallic acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgolide B
1 γ-linolenic acid (Borage Oil)
1 HydroxyCitric Acid
1 Hops (Humulus lupulus)
1 phytic acid, Inositol hexakisphosphate
1 itraconazole
1 Ivermectin
1 Juglone
1 Lactobacillus
1 Paclitaxel/Taxol
1 Methylglyoxal
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Niclosamide (Niclocide)
1 Oroxylin-A
1 Oleuropein
1 doxorubicin
1 Rauwolfia serpentina/Indian Snakeroot
1 Rutin
1 salinomycin
1 Gemcitabine (Gemzar)
1 Salvia miltiorrhiza
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:143  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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