MAPK Cancer Research Results

MAPK, mitogen-activated protein kinase: Click to Expand ⟱

Source: CGL-CS

Type:

Mitogen-activated protein kinases (MAPKs) are a group of proteins involved in transmitting signals from the cell surface to the nucleus, playing a crucial role in various cellular processes, including growth, differentiation, and apoptosis (programmed cell death).

MAPK Pathways: The MAPK family includes several pathways, the most notable being:
1.ERK (Extracellular signal-Regulated Kinase): Often associated with cell proliferation and survival.
2.JNK (c-Jun N-terminal Kinase): Typically involved in stress responses and apoptosis.
3.p38 MAPK: Associated with inflammatory responses and apoptosis.

Inhibitors: Targeting the MAPK pathway has become a strategy in cancer therapy. For example, BRAF inhibitors (like vemurafenib) are used in treating melanoma with BRAF mutations.
Altered Expression Levels:
Overexpression: Many cancers exhibit overexpression of MAPK pathway components, such as RAS, BRAF, and MEK. This overexpression can lead to increased signaling activity, promoting cell proliferation and survival.
Downregulation: In some cases, negative regulators of the MAPK pathway (e.g., MAPK phosphatases) may be downregulated, leading to enhanced MAPK signaling.
The expression levels of MAPK pathway components can serve as biomarkers for cancer diagnosis, prognosis, and treatment response. For example, high levels of phosphorylated ERK (p-ERK) may indicate active MAPK signaling and poor prognosis in certain cancers.

Numerous reports indicate that the MAPK pathway plays a major role in tumor progression and invasion, while inhibition of MAPK signaling reduces invasion.

Scientific Papers found: Click to Expand⟱

3559-

TQ,

Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease

-

Review,

AD,

NA

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2/PTGS2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,

5022-

UA,

Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks

-

Review,

Var,

NA

TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,

4869-

Uro,

Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges

-

Review,

AD,

NA

-

Review,

Park,

NA

-

Review,

Stroke,

NA

*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *Synergy↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,

4870-

Uro,

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

-

in-vivo,

AD,

NA

 APP/PS1 mice.

*cognitive↑, *Apoptosis↓, *neuroP↑, *Aβ↓, *AMPK↑, *NF-kB↓, *MAPK↓, *BACE/β-secretase↑, *neuroG↑, *Inflam↓, *memory↑,

4855-

Uro,

Urolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cells

-

in-vitro,

Bladder,

UMUC3

TumCCA↑, PI3K↓, Akt↓, MAPK↓,

3116-

VitC,

Vitamin C Inhibits NF-kB Activation by TNF Via the Activation of p38 Mitogen-Activated Protein Kinase

-

in-vitro,

Nor,

ECV304

-

in-vitro,

Nor,

HUVECs

*NF-kB↓, *p38↑, *MAPK↑,

3135-

VitC,

The interplay between vitamin C and thyroid

-

Review,

Thyroid,

NA

AntiCan↑, ChemoSen↑, radioP↑, MAPK↓, ERK↓, PI3K↓, Akt↓, QoL↑, OS↑,

2281-

VitK2,

The biological responses of vitamin K2: A comprehensive review

-

Review,

Var,

NA

*ROS↓, *12LOX↓, *NF-kB↓, *BMD↑, *hepatoP↑, cycD1/CCND1↓, PKCδ↓, STAT3↓, ERK↑, MAPK↓, ROS↑, PI3K↝, Akt↝, Hif1a↝, *neuroP↑,

1840-

VitK2,

The mechanisms of vitamin K2-induced apoptosis of myeloma cells

-

in-vitro,

Melanoma,

NA

TumCG↓, Apoptosis↑, Casp3↑, ROS↑, p‑MAPK↑,

1817-

VitK2,

Research progress on the anticancer effects of vitamin K2

-

Review,

Var,

NA

TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, Synergy↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, Synergy↑, Synergy↑,

7887-

VT,

IVT,

Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention

-

Review,

AD,

NA

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,

Showing Research Papers: 301 to 311 of 311
Prev Page 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 311

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7, antiOx⇅, 1, Catalase↓, 6, Catalase↑, 3, Fenton↑, 2, GPx↓, 1, GPx↑, 1, GPx4↓, 4, GPx4↑, 1, GSH↓, 21, GSH↑, 5, GSH/GSSG↓, 2, GSR↓, 2, GSR↑, 1, ox-GSSG↑, 1, GSTs↓, 1, GSTs↑, 1, H2O2↑, 3, HNE↑, 1, HO-1↓, 6, HO-1↑, 10, Iron↓, 1, Iron↑, 4, Iron↝, 1, Keap1↝, 1, lipid-P?, 1, lipid-P↓, 5, lipid-P↑, 8, MDA↓, 3, MDA↑, 6, MPO↓, 1, NQO1↓, 2, NQO1↑, 2, NRF2↓, 8, NRF2↑, 13, NRF2↝, 1, RNS↑, 1, ROS?, 1, ROS↓, 16, ROS↑, 131, ROS⇅, 6, ROS∅, 1, i-ROS↑, 1, m-ROS↑, 1, mt-ROS↑, 3, SAM-e↝, 1, SOD?, 1, SOD↓, 6, SOD↑, 6, SOD1↓, 1, SOD2↓, 1, TAC↓, 1, TOS↑, 1, Trx1↑, 1, TrxR↓, 1, TrxR1↓, 1, VitC↓, 1, VitE↓, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1, IronCh↑, 2, Tf↓, 2, Tf↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 7, CDC25↓, 7, compI↓, 2, compIII↓, 2, compV↓, 1, EGF↓, 4, ETC↓, 2, Insulin↓, 1, MFN2↑, 1, mitResp↓, 3, mtDam↑, 9, OCR↓, 2, OXPHOS↑, 2, OXPHOS↝, 1, PDH↝, 1, PINK1↑, 1, SIRT3↓, 1, SIRT3↑, 3,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2, 5LO↓, 2, Acetyl-CoA↓, 1, ACLY↓, 1, ACSL4↑, 1, adiP↑, 1, AMPK?, 1, AMPK↑, 14, ATGL/PNPLA2↓, 1, ATP↓, 9, ATP↑, 1, CAIX/CA9↑, 1, DHODH↓, 1, ECAR↓, 1, FASN↓, 3, FFA/NEFA↓, 1, GAPDH↓, 1, GLO-I↓, 1, glucose↓, 1, GlutMet↓, 1, glyC↓, 1, Glycolysis↓, 12, GSK‐3β↓, 3, GSK‐3β↑, 6, p‑GSK‐3β↓, 1, H2S↑, 1, HK1↓, 1, HK2↓, 5, HSL/LIPE↓, 1, p‑HSL/LIPE↑, 1, lactateProd↓, 3, LDHA↓, 3, NAD↝, 1, NADPH↓, 2, NADPH↑, 1, O-Glc↓, 1, PCK1↓, 2, PDK1 / PDPK1↓, 1, PFK↓, 1, PKM2↓, 5, Pyruv↓, 1, SIRT1↓, 3, SIRT1↑, 3, SREBP2↓, 1, TCA↓, 2, TumCM/A↑, 1, Warburg↓, 6,

Cell Death(tgid=5) ⓘ

AIF↑, 10, APAF1↑, 7, Apoptosis?, 1, Apoptosis↓, 3, Apoptosis↑, 118, mt-Apoptosis↑, 2, ASC↓, 1, BAD↑, 6, Bak↑, 7, BAX↑, 69, Bax:Bcl2↑, 10, Bcl-2↓, 70, Bcl-xL↓, 14, BID↓, 1, BID↑, 6, BIM↓, 1, BIM↑, 3, BNIP3↑, 1, BNIP3↝, 1, BOK↑, 1, Casp↓, 1, Casp↑, 26, cl‑Casp↑, 1, Casp1↓, 1, cl‑Casp12↑, 1, Casp2↑, 1, Casp3↓, 3, Casp3↑, 65, cl‑Casp3↑, 16, cl‑Casp3⇅, 1, proCasp3↑, 1, Casp7↑, 4, cl‑Casp7↑, 3, Casp8↑, 20, cl‑Casp8↑, 1, Casp9↑, 51, cl‑Casp9↑, 7, proCasp9↓, 1, cFLIP↓, 1, Cyt‑c↓, 2, Cyt‑c↑, 49, Diablo↑, 2, DR5↑, 20, FADD↑, 2, Fas↓, 2, Fas↑, 14, FasL↑, 8, Ferroptosis↓, 1, Ferroptosis↑, 11, GSDME↑, 1, HEY1↓, 1, IAP1↓, 3, IAP2/BIRC3↓, 2, cl‑IAP2/BIRC3↑, 1, iNOS↓, 7, Mcl-1↓, 12, Mcl-1↑, 1, MDM2↓, 4, MDM2↑, 1, p‑MDM2↓, 1, MOMP↓, 1, MOMP↑, 1, NAIP↓, 1, Necroptosis↑, 3, necrosis↑, 2, p38↓, 6, p38↑, 30, p‑p38↓, 2, p‑p38↑, 5, PUMA↑, 1, PUMA⇅, 1, Pyro↑, 2, survivin↓, 22, TNFR 1↑, 1, TRAIL↑, 2, TRAILR↑, 1, TumCD↓, 1, TumCD↑, 6, XIAP↓, 13, YAP/TEAD↓, 4,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 91, Akt↑, 3, Akt↝, 2, p‑Akt↓, 13, p‑Akt↑, 2, AKT1↓, 1, Akt2↓, 2, AMPKα↑, 1, BRAF↑, 1, BRAF↝, 1, CIP2A↓, 2, CK2↓, 3, cMET↓, 3, DDIT4↑, 1, EF-1α↓, 1, EGFR↓, 15, EGFR↑, 1, p‑EGFR↓, 2, EphB4↓, 1, ERK↓, 47, ERK↑, 14, ERK↝, 2, p‑ERK↓, 9, p‑ERK↑, 3, p‑ERK⇅, 1, FGFR1↓, 1, FOXD3↑, 1, HER2/EBBR2↓, 11, HGF/c-Met↓, 3, IGF-1R↓, 2, IKKα↓, 5, p‑IKKα↓, 2, IR↓, 1, JAK↓, 8, p‑JAK↓, 1, JAK1↓, 2, JAK2↓, 5, JNK↓, 9, JNK↑, 30, JNK↝, 1, p‑JNK↓, 1, p‑JNK↑, 4, p‑MAP2K1/MEK1↓, 1, MAPK?, 1, MAPK↓, 123, MAPK↑, 75, MAPK↝, 6, p‑MAPK↓, 6, p‑MAPK↑, 12, MEK↓, 3, p‑MEK↓, 2, mTOR↓, 45, mTOR↝, 1, p‑mTOR↓, 5, mTORC2↓, 2, NRAS↓, 1, p42↑, 1, p‑p42↑, 1, p70S6↓, 1, p‑p70S6↑, 1, P70S6K↓, 5, PAK↓, 1, PDE3B↓, 1, PDGFR-BB↓, 1, p‑PDGFR-BB↓, 1, PI3K↓, 80, PI3K↑, 3, PI3K↝, 3, p‑PI3K↓, 3, PI3K/Akt↓, 3, PI3K/Akt↑, 1, PI3K/Akt↝, 1, PI3k/Akt/mTOR↓, 1, PIK3CA↓, 1, PKA↓, 1, p‑PKA↓, 1, PKCδ↓, 7, PTEN↓, 3, PTEN↑, 9, PTEN↝, 1, Raf↓, 5, e-Raf↓, 1, c-Raf↓, 1, RAS↓, 8, RAS↑, 1, RET↓, 1, Rictor↓, 1, Sp1/3/4↓, 5, Src↓, 2, p‑Src↓, 1, STAT↓, 5, p‑STAT↓, 1, STAT3↓, 34, STAT3↑, 2, STAT3↝, 1, p‑STAT3↓, 5, p‑STAT3↑, 1, STAT4↓, 1, STAT5↓, 4, p‑STAT6↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↓, 1, ATF3↑, 1, ATF4↓, 1, ATF4↑, 5, CBP↓, 1, cJun↓, 2, cJun↑, 2, cMyc↓, 12, DNMT1↓, 7, DNMT3A↓, 2, DNMTs↓, 3, EZH2↓, 1, FOXO↓, 1, FOXO↑, 1, FOXO1↓, 2, FOXO1↑, 1, FOXO3↓, 1, FOXO3↑, 2, H3↓, 1, H3↑, 2, p‑H3↓, 1, H4↓, 1, H4↑, 2, HATs↓, 2, HATs↑, 2, HDAC↓, 10, HDAC1↓, 3, HDAC2↓, 1, HDAC3↓, 1, HDAC4↓, 2, HDAC8↓, 1, miR-107↑, 2, miR-139-5p↑, 2, miR-155↓, 3, miR-200b↑, 2, miR-21↓, 6, miR-21↑, 1, miR-218↑, 1, miR-224↓, 2, miR-25-5p↓, 1, miR-29b↑, 1, miR-330-5p↑, 1, miR-340↓, 2, miR-34a↑, 4, miR-384↑, 1, miR-422a↑, 2, Myc↓, 1, MYCN↓, 1, NDRG1↑, 2, OCT4↓, 3, other↓, 3, other↑, 3, other↝, 2, Shc↓, 1, SOX2↓, 6, SOX4↓, 1, TCF-4↓, 1, TFE3↑, 1, tumCV?, 1, tumCV↓, 22,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1, CHOP/DDIT3↑, 12, cl‑CHOP/DDIT3↑, 1, eIF2α↓, 2, eIF2α↑, 4, p‑eIF2α↑, 1, ER Stress↑, 23, GRP78/BiP?, 1, GRP78/BiP↑, 5, HSF1↓, 1, HSP27↓, 2, HSP70/HSPA5↓, 2, HSP70/HSPA5↑, 1, HSP90↓, 8, HSP90↑, 1, HSPs↓, 1, HSPs↑, 1, IRE1↑, 1, PERK↑, 4, Proteasome↓, 1, SERPINH1/HSP47↓, 1, UPR↑, 3,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1, ATG5↑, 5, ATG7↑, 3, Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 13, CTSB↓, 1, CTSD↓, 1, LAMP2↓, 1, LAMP2↑, 1, LC3B↑, 1, LC3B-II↑, 1, LC3I↑, 1, LC3II↑, 15, LC3s↑, 1, p62↓, 3, p62↑, 1, PARK2↑, 1, SESN2↑, 2, TumAuto↑, 30, VMP-1↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2, BRCA1↓, 1, BRCA1↑, 1, DNAdam↑, 34, DNArepair↓, 2, DNArepair↑, 1, ERCC3↑, 1, hTERT/TERT↓, 6, p16↑, 1, P53↓, 1, P53↑, 55, p‑P53↓, 1, p‑P53↑, 2, p53 Wildtype↓, 1, PARP↓, 3, PARP↑, 13, p‑PARP↑, 1, cl‑PARP↑, 26, PARP1↑, 1, PCNA↓, 13, SIRT6↓, 1, Telomerase↓, 5, TOP1↓, 6, TOP2↓, 3, TOP2↑, 1, TP53↑, 2, UHRF1↓, 1, XRCC1↓, 1, γH2AX↑, 6, γH2AX↝, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1, CDK1↓, 10, CDK1↑, 3, CDK2↓, 21, CDK2↑, 2, CDK4↓, 28, CDK4↑, 2, CDK6↓, 6, CDK6↑, 3, CDKN1C/p57↑, 1, CHK1↓, 2, CHK1↑, 1, p‑CHK1↑, 1, Chk2↓, 2, Chk2↑, 1, Cyc↓, 3, cycA1/CCNA1↓, 5, cycA1/CCNA1↑, 1, CycB/CCNB1↓, 13, CycB/CCNB1↑, 1, cycD1/CCND1↓, 36, CycD3↓, 1, cycE/CCNE↓, 8, cycE/CCNE↑, 1, E2Fs↓, 1, E2Fs↑, 1, FBXO5/EMI1↓, 1, Ki-67↓, 14, MAD↓, 1, P21?, 1, P21↓, 2, P21↑, 34, p27/CDKN1B↑, 17, p‑pRB↓, 4, RB1↑, 2, p‑RB1↓, 3, Securin↓, 1, TAp63α↑, 1, TumCCA↓, 3, TumCCA↑, 106,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2, Axin2↑, 1, BMP7/OP1↓, 1, CD133↓, 4, CD24↓, 2, CD34↓, 2, cFos↓, 3, cFos↑, 1, CSCs?, 1, CSCs↓, 16, CSCsMark↓, 2, Diff↓, 1, Diff↑, 2, FGF↓, 2, FGF↑, 1, Gli1↓, 1, IGF-1↓, 9, IGFBP1↑, 1, IGFBP3↑, 2, Jun↓, 2, Ki-67↓, 14, Let-7↑, 1, mTORC1↓, 3, Nanog↓, 4, Nestin↓, 1, NOTCH↓, 12, NOTCH1↓, 5, NOTCH3↓, 1, p300↓, 1, Shh↓, 3, Smo↓, 1, STAT1↓, 1, TumCG↓, 31, TumCG↑, 3, TumCP?, 1, TumCP↓, 81, TumCP↑, 3, TumCP∅, 1, Wnt↓, 29, Wnt↝, 1, Wnt/(β-catenin)↓, 5, ZFX↓, 1,

Migration(tgid=13) ⓘ

AntiAg?, 1, AntiAg↑, 2, AP-1↓, 8, AP-1↑, 3, ATPase↓, 1, AXL↓, 2, Ca+2↓, 1, Ca+2↑, 24, cal2↑, 1, CCN2/CTGF↓, 1, Cdc42↓, 1, Chl↑, 1, Cofilin↓, 1, p‑Cofilin↑, 2, DLC1↑, 1, E-cadherin↓, 2, E-cadherin↑, 20, EMT↓, 37, EMT↑, 1, F-actin↓, 2, FAK↓, 14, FAK↑, 1, p‑FAK↓, 1, fascin↓, 1, Fibronectin↓, 2, IQGAP3↓, 1, ITGA5↓, 2, ITGB1↓, 2, ITGB4↓, 1, LAMs↓, 1, LIMK2↓, 1, MALAT1↓, 1, MET↓, 2, p‑MET↓, 1, MMP-10↓, 1, MMP1↓, 4, MMP11↓, 1, MMP13↓, 3, MMP16↓, 2, MMP2↓, 48, MMP3↓, 3, MMP7↓, 8, MMP9↓, 54, MMP9↑, 1, MMP9:TIMP1↓, 1, MMPs↓, 22, MUC4↓, 1, N-cadherin↓, 13, NEDD9↓, 1, NFAT↑, 1, p44↑, 1, p‑p44↑, 1, PAK1↓, 1, PDGF↓, 5, Rac1↓, 2, Rho↓, 4, ROCK1↓, 2, Slug↓, 3, Smad1↝, 1, SMAD3↓, 2, Snail↓, 6, STAC2↓, 1, TET1↓, 1, TET1↑, 1, TGF-β↓, 13, TGF-β↑, 2, TGF-β↝, 1, TIMP1↓, 1, TIMP1↑, 7, TIMP2↓, 1, TIMP2↑, 4, TRIB3↑, 1, TSP-1↑, 2, TumCA↑, 1, TumCI↓, 46, TumCMig↓, 36, TumCMig↑, 1, TumMeta↓, 44, TumMeta↑, 2, TumPF↓, 1, Twist↓, 9, Tyro3↓, 1, uPA↓, 15, uPAR↓, 3, Vim↓, 17, Vim↑, 1, Zeb1↓, 7, ZEB2↓, 1, α-tubulin↑, 1, β-catenin/ZEB1↓, 31, β-catenin/ZEB1↑, 2,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 47, angioG↑, 2, CCN1/CYR61↓, 1, CD31/PECAM-1↓, 1, eNOS↓, 1, HIF-1↓, 3, Hif1a↓, 24, Hif1a↝, 1, NO↓, 1, NO↑, 1, VCAM-1↓, 1, VEGF↓, 48, VEGFR2/KDR/Flk1↓, 15,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2, CLDN1↓, 2, CLDN1↑, 1, EPR↑, 3, GLUT1↓, 4, GLUT1↑, 1, GLUT3↑, 1, GLUT4↓, 1, IBI↑, 1, memfluid↓, 1, MMP?, 1, MMP↓, 54, MPT↑, 1, OCLN↑, 1, TJ↑, 1, TRPM7↓, 5, ZO-1↑, 2,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1, CD4+↓, 1, CD4+↑, 1, CD44↓, 6, CD8+↑, 1, COX2/PTGS2↓, 39, CXCL1↓, 1, CXCR2↓, 1, CXCR4↓, 6, CXCR4↑, 1, DR4↑, 6, FOXP3↓, 1, HMGB1↓, 2, ICAM-1↓, 2, IFN-γ↓, 2, IFN-γ↑, 3, IL1↓, 6, IL10↓, 4, IL10↑, 1, IL12↓, 2, IL12↑, 1, IL18↓, 2, IL1α↓, 1, IL1β↓, 9, IL2↓, 2, IL2↑, 3, IL4↓, 1, IL5↓, 1, IL6↓, 23, IL8↓, 6, Imm↑, 6, Inflam↓, 21, M2 MC↓, 2, MCP1/CCL2↓, 3, MDSCs↓, 1, MIP2↓, 1, NF-kB?, 2, NF-kB↓, 84, NF-kB↑, 2, NF-kB↝, 1, NK cell↑, 5, NLRP3↓, 4, NLRP3↑, 1, NOD1↓, 1, p65↓, 5, p‑p65↓, 1, PD-1↓, 2, PD-L1↓, 1, PGE2↓, 8, PSA↓, 6, T-Cell↑, 1, Th1 response↓, 1, Th1 response↑, 1, Th2↑, 1, TLR4↓, 2, TNF-α↓, 18, TNF-α↑, 2, Treg lymp↓, 2,

Cellular Microenvironment(tgid=17) ⓘ

pH∅, 1, e-pH↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, PTN↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1, AR↓, 8, ER-α36↓, 1, ER(estro)↓, 1, PPARα↓, 1, PPARγ↑, 2, RANKL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1, BioAv↓, 23, BioAv↑, 27, BioAv↝, 5, ChemoSen?, 1, ChemoSen↓, 1, ChemoSen↑, 78, ChemoSen↝, 1, CompStab↓, 3, CompStab↑, 2, CompStab↝, 1, CYP1A1↓, 3, CYP1A1↑, 3, CYP1A2↓, 1, CYP1B1↑, 1, CYP3A4↓, 1, Dose↑, 4, Dose⇅, 1, Dose↝, 20, Dose∅, 2, DrugR↓, 1, eff↓, 20, eff↑, 37, eff↝, 6, Half-Life↓, 9, Half-Life↝, 4, Half-Life∅, 1, MDR1↓, 2, MRP1/ABCC1↓, 2, P-gp/ABCB1↓, 11, P450↓, 1, RadioS↑, 23, selectivity↑, 30, selectivity∅, 1, Synergy↑, 43, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, ALB↝, 1, AR↓, 8, ascitic↓, 1, BG↓, 1, BRAF↑, 1, BRAF↝, 1, BRCA1↓, 1, BRCA1↑, 1, CA125↓, 1, CEA↓, 1, CRP↓, 1, E6↓, 2, E7↓, 2, EGFR↓, 15, EGFR↑, 1, p‑EGFR↓, 2, EZH2↓, 1, HER2/EBBR2↓, 11, hTERT/TERT↓, 6, IL6↓, 23, IRes↓, 1, LDH↓, 2, LDH↑, 1, i-LDH↓, 1, Maspin↑, 1, Myc↓, 1, NSE↓, 1, PD-L1↓, 1, PSA↓, 6, TP53↑, 2, TRIB3↑, 1, Tumccf↓, 2,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 34, AntiCan?, 1, antiCG↓, 1, AntiDiabetic↑, 2, antiNeop↑, 1, AntiTum↓, 1, AntiTum↑, 16, cachexia↓, 1, cardioP↑, 6, chemoP↑, 16, chemoPv↑, 8, ChemoSideEff↓, 5, cognitive↑, 1, hepatoP↑, 7, neuroP↑, 6, OS↑, 7, Pain↓, 1, QoL↑, 1, radioP↑, 5, RenoP↑, 8, Risk↓, 3, toxicity↓, 7, toxicity↑, 2, toxicity↝, 5, toxicity∅, 2, TumVol↓, 7, TumVol∅, 1, TumW↓, 1, TumW∅, 1, Weight↑, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1, AntiP↑, 1, Bacteria↓, 2, GutMicro↑, 6, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,
Total Targets: 816

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4, antiOx↑, 66, ARE↑, 3, Bil↑, 2, Catalase↑, 32, Fenton↓, 3, GCLC↑, 2, GCLM↑, 2, GPx↑, 22, GPx1↑, 1, GPx4↑, 2, GSH↑, 33, GSR↓, 1, GSR↑, 8, GSTs↓, 1, GSTs↑, 6, H2O2↓, 3, H2O2∅, 1, HDL↑, 2, HNE↓, 1, HNE↑, 1, HO-1↓, 1, HO-1↑, 32, hyperG↝, 1, Keap1↓, 3, lipid-P?, 1, lipid-P↓, 28, MDA↓, 29, MPO↓, 5, NQO1↑, 6, NRF2↓, 3, NRF2↑, 51, Prx↑, 1, RNS↓, 3, ROS↓, 82, ROS↑, 2, SOD↓, 1, SOD↑, 45, SOD1↑, 5, SOD2↑, 2, TAC↑, 8, TBARS↓, 1, Trx↑, 1, uricA↓, 1, VitC↑, 1, VitE↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1, FPN↑, 1, IronCh↑, 4, TfR1/CD71↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1, MFN2↑, 1, mtDam↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1, 15-LOX/ALOX15↓, 1, 5LO↓, 2, ALAT?, 1, ALAT↓, 5, AMP↓, 1, AMPK↓, 1, AMPK↑, 11, AMPK↝, 1, ATP↑, 3, Buty↑, 1, cAMP↑, 2, CRM↑, 1, glucose↑, 1, glucose↝, 1, GlucoseCon↑, 2, Glycolysis↑, 1, GSK‐3β↓, 4, GSK‐3β↑, 1, H2S↑, 1, HMG-CoA↓, 1, LDHA↑, 1, LDL↓, 4, lipidLev↓, 1, NADPH↓, 4, NADPH↑, 2, SCFAs↑, 1, SIRT1↑, 5, SIRT1↝, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 14, BAD↓, 1, BAX↓, 4, BAX↑, 1, Bcl-2↓, 2, Bcl-2↑, 1, Casp3?, 1, Casp3↓, 15, Casp3↑, 1, Casp3∅, 1, cl‑Casp3↓, 1, Casp8↓, 3, cl‑Casp8↓, 1, Casp9↓, 5, Casp9∅, 1, Cyt‑c↓, 2, Cyt‑c∅, 1, Fas↓, 1, Ferroptosis↓, 3, HEY1↑, 1, iNOS↓, 22, iNOS↑, 2, necrosis↓, 2, p38↓, 7, p38↑, 4, p‑p38↓, 5, Pyro↓, 1,

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9, Akt↑, 20, Akt↝, 2, AKT1↓, 1, Akt2↓, 1, CREB↑, 2, EGFR↓, 2, ERK↓, 8, ERK↑, 8, p‑ERK↓, 5, p‑ERK↑, 1, HGF/c-Met↑, 1, IGF-1R↓, 1, IGF-1R↑, 1, IKKα↓, 2, p‑IKKα↓, 1, IκB↓, 1, p‑IκB↓, 1, JAK↓, 2, JAK2↓, 1, p‑JAK2↓, 1, JNK↓, 6, JNK↑, 1, p‑JNK↓, 6, LPAR1/EDG2↑, 1, MAPK?, 1, MAPK↓, 70, MAPK↑, 15, MAPK↝, 4, p‑MAPK?, 1, p‑MAPK↓, 3, mTOR↓, 1, mTOR↑, 3, mTOR↝, 1, PDGFR-BB↓, 2, PDGFRB↓, 1, PI3K↓, 8, PI3K↑, 15, PI3K↝, 2, PKA↑, 3, PKCδ↓, 3, PKCδ↑, 3, PP2A↑, 1, PTEN↓, 4, PTEN↑, 1, RAS↓, 1, RIP1↓, 1, Src↓, 1, p‑Src↑, 1, STAT↓, 3, STAT3↓, 4, STAT3↝, 1, p‑STAT3↓, 1, STAT4↓, 1, STAT5↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2, ATF2↑, 1, cMyc↓, 1, FOXO3↑, 1, HDAC↓, 1, other↓, 2, other↑, 3, other↝, 5, SOX9↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 1, ER Stress↓, 1, GRP78/BiP↑, 1, GRP94↑, 1, HSP27↑, 1, HSP70/HSPA5↑, 2, HSP90↓, 1, HSP90↑, 1, HSPs↓, 1, HSPs↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↑, 1, Beclin-1/ATG6↓, 2, MitoP↑, 1, p62↓, 1, p62↑, 2, PARK2↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2, p16↓, 2, P53↓, 4, P53↑, 1, PARP↓, 1, PARP∅, 1, TP53↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1, E2Fs↑, 1, P21↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1, Diff↑, 1, Diff↝, 1, HH↓, 1, IGF-1↓, 1, IGF-1↑, 1, IGFBP3↑, 1, Jun↓, 1, neuroG↑, 3, NOTCH↑, 1, STAT1↓, 1, TumCP↓, 2, Wnt↑, 1, Wnt↝, 1, Wnt/(β-catenin)↓, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 5, AP-1↓, 5, ARG1/2↑, 1, Ca+2↓, 4, Ca+2↑, 2, Ca+2↝, 1, Cartilage↑, 3, COL1↓, 1, FAK↑, 1, p‑FAK↑, 1, Fibrosis↓, 1, heparanase↑, 1, MLC2/MYL9↝, 1, MMP2↓, 2, MMP9↓, 6, MMP9↑, 1, MMPs↓, 2, TGF-β↓, 1, TGF-β↑, 1, TGF-β1↓, 1, TGF-β1↑, 2, TIMP1↓, 1, TregCell↑, 1, TumCI↓, 1, TXNIP↓, 1, α-SMA↓, 1, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, angioG↑, 2, E-sel↓, 2, eNOS↑, 2, Hif1a↓, 1, NO↓, 15, VCAM-1↓, 10, VEGF↓, 2, VEGF↑, 3,

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1, BBB?, 1, BBB↑, 16, CLDN1↓, 1, GastroP↑, 1, GLUT1↑, 1, GLUT2↑, 1, GLUT4↑, 4, H+/K+-ATPase↓, 1, IBI↑, 3, MMP↑, 8, MUC19↓, 1, MUC2↓, 1, OCLN↓, 1, OCLN↑, 1, OCLN↝, 1, TJ↑, 3, TRPA1↑, 1, TRPV1↑, 1, ZO-1↓, 1, ZO-1↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2, COX2/PTGS2↓, 29, CXCR4↓, 1, HMGB1↓, 1, ICAM-1↓, 8, IFN-γ↓, 3, IFN-γ↑, 2, IL1↓, 2, IL10↑, 9, IL12↓, 2, IL13↑, 1, IL17↓, 2, IL18↓, 1, IL1β↓, 32, IL2↓, 1, IL4↓, 4, IL4↑, 1, IL5↓, 1, IL6?, 1, IL6↓, 30, IL6↑, 1, IL8↓, 7, Imm↑, 2, Imm⇅, 1, Imm↝, 1, Inflam↓, 86, Inflam↑, 1, IRF3↓, 1, Macrophages↓, 1, MCP1/CCL2↓, 4, MIP2↓, 1, MyD88↓, 3, NeuroI↓, 2, Neut↓, 1, NF-kB↓, 70, NF-kB↑, 3, p‑NF-kB↓, 1, NLRP3↓, 13, NLRP3↑, 1, p65↓, 1, p‑p65↓, 1, PAF↓, 1, PGE1↓, 1, PGE2↓, 13, RAGE↓, 1, RANTES↓, 1, Th1 response↓, 1, Th17↓, 1, TLR1↓, 1, TLR2↓, 3, TLR4↓, 12, TLR4↑, 1, TNF-α↓, 45, TNF-α↑, 2, TRIF↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, 5HT↑, 4, Ach↑, 2, AChE↓, 12, ADAM10↑, 1, BChE↓, 2, BDNF↑, 9, BDNF∅, 1, BrainVol↑, 1, ChAT↑, 1, GABA↑, 1, MAOA↓, 3, MAOB↓, 1, NGF↑, 2, TPH1↓, 1, TrkB↑, 3,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2, APP↓, 3, Aβ↓, 17, Aβ42↓, 2, BACE/β-secretase↓, 5, BACE/β-secretase↑, 1, IDE↑, 1, tau↓, 5, p‑tau↓, 4,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1, ACE2↓, 1, GLP-1R↑, 1, GR↑, 1, PPARα↑, 1, PPARγ↓, 3, PPARγ↑, 4, TSHR↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 25, BioAv↑, 23, BioAv↝, 12, BioEnh↑, 2, ChemoSen↑, 1, CYP2D6↓, 1, Dose↑, 1, Dose⇅, 1, Dose↝, 12, eff↓, 1, eff↑, 11, eff↝, 2, GSTA1↓, 1, GSTA1↑, 1, Half-Life↓, 2, Half-Life↑, 2, Half-Life↝, 4, P450↓, 1, Synergy↑, 4,

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1, ALAT↓, 5, ALP↓, 1, anemia↓, 1, AST↓, 5, Bil↑, 2, BloodF↑, 1, BMD↑, 3, BP↓, 1, BP↝, 1, BUN↓, 1, CEA↓, 1, colonLen↑, 1, CRP↓, 6, EGFR↓, 2, Ferritin↓, 1, HemoG↑, 1, hs-CRP↓, 1, IL6?, 1, IL6↓, 30, IL6↑, 1, IRes↑, 1, IRes↝, 1, LDH↓, 5, LDH↑, 1, NOS2↓, 1, RAGE↓, 1, RBC↑, 1, TP53↑, 1,

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1, AntiAge↑, 3, antiAll↑, 7, AntiArt↑, 3, AntiCan↑, 8, antiCG↑, 2, AntiDiabetic↓, 1, AntiDiabetic↑, 6, antiPs↑, 1, AntiTum↑, 1, cardioP↑, 23, chemoP↑, 5, chemoPv↑, 1, cognitive↑, 22, diuretic↑, 2, hepatoP↓, 1, hepatoP↑, 22, memory↑, 21, motorD↑, 2, Mucositis↓, 1, neuroP↑, 59, Obesity↓, 5, Pain↓, 2, radioP↑, 4, RenoP↑, 7, Risk↓, 1, Strength↑, 2, Stroke↓, 6, toxicity?, 1, toxicity↓, 13, toxicity↝, 6, toxicity∅, 3, Wound Healing↑, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6, AntiFungal↑, 4, AntiP↑, 1, AntiViral↑, 7, Bacteria↓, 8, Diar↓, 2, GutMicro↑, 9, Sepsis↓, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 7,
Total Targets: 450

Scientific Paper Hit Count for: MAPK, mitogen-activated protein kinase

13 Quercetin
9 Thymoquinone
8 Allicin (mainly Garlic)
8 Berberine
8 Luteolin
7 Chlorogenic acid
7 Curcumin
7 Magnetic Fields
7 Silymarin (Milk Thistle) silibinin
6 Chrysin
6 Fisetin
6 Licochalcone A
5 Apigenin (mainly Parsley)
5 Isovitexin
5 Betulinic acid
5 Propolis -bee glue
5 Emodin
4 Alpha-Lipoic-Acid
4 Cisplatin
4 Baicalein
4 Caffeic acid
4 Carvacrol
4 EGCG (Epigallocatechin Gallate)
4 isoorientin
4 Kaempferol
4 Lycopene
4 Magnolol
4 Resveratrol
3 beta-glucans
3 Boron
3 Copper and Cu NanoParticles
3 Sulforaphane (mainly Broccoli)
3 Piperine
3 Formononetin
3 Fucoidan
3 Gallic acid
3 Gambogic Acid
3 Garcinol
3 Hyperoside
3 Lactoferrin/Talactoferrin
3 Melatonin
3 Urolithin
3 Vitamin K2
2 1,8-Cineole
2 Anethole/trans-Anethole
2 Chemotherapy
2 Ashwagandha(Withaferin A)
2 Beta-Caryophyllene
2 Bromelain
2 Boswellia (frankincense)
2 brusatol
2 Carnosic acid
2 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Echinacea
2 Cynaropicrin
2 diet FMD Fasting Mimicking Diet
2 Disulfiram
2 Ellagic acid
2 Evodiamine
2 Ferulic acid
2 Flaxseed/Linseed
2 Ginseng
2 Honokiol
2 Isoliquiritigenin
2 Vitexin
2 Juglone
2 Naringin
2 Nimbolide
2 Oxygen, Hyperbaric
2 Phenethyl isothiocyanate
2 Piperlongumine
2 Pterostilbene
2 Rutin
2 salinomycin
2 Aflavin-3,3′-digallate
2 Vitamin C (Ascorbic Acid)
1 3-bromopyruvate
1 Silver-NanoParticles
1 Paclitaxel/Taxol
1 DTS(dibenzyl trisulphide) from Anamu
1 Bicarbonate(Sodium)
1 Astaxanthin
1 Baicalin
1 Berbamine
1 Benzyl isothiocyanate
1 Bacopa monnieri
1 Black Rice, Oryza sativa
1 Bruteridin(bergamot juice)
1 Mung Bean Sprouts
1 Capsaicin
1 Celastrol
1 Cinnamon
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Chlorella (Chlorella vulgaris)
1 Deguelin
1 immunotherapy
1 Eurycomanone
1 Eugenol
1 Trastuzumab
1 Ginkgo biloba
1 Ginkgolide B
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Hydroxycinnamic-acid
1 HydroxyTyrosol
1 Isobavachalcone
1 Inositol
1 isoquercitrin
1 Ivermectin
1 L-Theanine
1 Licorice
1 Linalool
1 Methylene blue
1 Photodynamic Therapy
1 Methyl Jasmonate
1 Methyl salicylate / Sweet Birch oil
1 Radiotherapy/Radiation
1 Magnetic Field Rotating
1 Magnesium
1 Mangiferin
1 Methylglyoxal
1 Morin
1 Mushroom Chaga, Inonotus obliquus
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Myricetin
1 Orlistat
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 Purple Corn / Purple Maize
1 Propyl gallate
1 Phycocyanin
1 Plumbagin
1 Rosmarinic acid
1 buckwheat sprouts
1 Salvia officinalis
1 Oxaliplatin
1 Sanguinarine
1 Selenium
1 Selenium NanoParticles
1 Shikonin
1 Terminalia bellirica
1 5-fluorouracil
1 Ursolic acid

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:181  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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