Synergy Cancer Research Results

Synergy, Synergy: Click to Expand ⟱
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Synergy — Interaction in which two or more agents, treatments, or biological interventions produce a combined effect greater than would be expected from their individual effects. In pharmacology and cancer research, synergy commonly refers to enhanced therapeutic efficacy when a compound is combined with chemotherapy, radiation, targeted therapy, or another bioactive agent.

Typical modulation in cancer: ↑ synergy is generally favorable when it increases tumor-cell killing, suppresses proliferation, enhances apoptosis or ferroptosis, or improves sensitivity to anticancer therapy. Synergy should be distinguished from simple additive effects and ideally supported by quantitative combination analysis such as combination index, Bliss independence, Loewe additivity, or related methods.

Typical modulation in Alzheimer’s disease: Context-dependent. Synergy may describe enhanced neuroprotective, anti-inflammatory, antioxidant, or cognitive effects produced by combinations of compounds or treatments, but it is not a disease-specific molecular pathway.
Scientific Papers found: Click to Expand⟱
2387- MET,  GEM,    Metformin Increases the Response of Cholangiocarcinoma Cells to Gemcitabine by Suppressing Pyruvate Kinase M2 to Activate Mitochondrial Apoptosis
- in-vitro, CCA, HCC9810
Synergy↑, tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, PKM2↓, PDHB↓,
5800- MET,    Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
- Review, Var, NA
ChemoSen↑, RadioS↑, Imm↑, *AntiDiabetic↑, *AMPK↑, TumCP↓, hepatoP↑, ATP↓, AMP↑, glucoNG↓, ROS↑, compI↓, DNAdam↑, CSCs↓, NP/CIPN↓, chemoP↑, toxicity↓, Trx↓, Synergy↑, cycD1/CCND1↓, CDK4↓, CDK6↓, cycE/CCNE↓, CDK2↓,
4352- MF,    Differences in lethality between cancer cells and human lymphocytes caused by LF-electromagnetic fields
- in-vitro, lymphoma, K562 - NA, NA, U937 - NA, NA, HL-60
Apoptosis↑, Synergy↑,
6936- MF,  Ex,    Pulsed electromagnetic field with or without exercise therapy in the treatment of benign prostatic hyperplasia
- Trial, BPH, NA
*eff↑, *Synergy↑, *BloodF↑, *Diff↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *UFR↑, *UR↓, *PSA↓, *other↑, *Inflam↓,
523- MF,  MTX,    Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage
- in-vitro, AML, THP1 - in-vitro, NA, PC12 - in-vivo, Cerv, HeLa
H2O2↑, TumCD↑, CellMemb↑, Synergy↑,
595- MFrot,  VitC,  MF,    The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells
- in-vitro, PC, MIA PaCa-2 - in-vitro, CRC, SW-620 - in-vitro, NA, HT1080 - in-vitro, Pca, PC3 - in-vitro, OS, U2OS - in-vitro, BC, MCF7 - in-vitro, Nor, CCD-18Co
TumCD↑, Synergy↑, *TumCG∅,
786- Mg,  VitC,    A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer
Risk↓, *VitD↑, *pH↝, *ROS↓, TumCG↓, Synergy↑,
2257- MNPs,  HPT,    HSP70 Inhibition Synergistically Enhances the Effects of Magnetic Fluid Hyperthermia in Ovarian Cancer
- in-vitro, Ovarian, NA
Synergy↑, Synergy↑,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *Synergy↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
5611- NaHCO3,    NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells
- vitro+vivo, HCC, HepG2
tumCV↓, TumCG↓, pH↑, Synergy↑, Imm↑,
5620- NaHCO3,    Tumor acidity: From hallmark of cancer to target of treatment
- Review, Var, NA
e-pH↑, TumCG↓, ChemoSen↑, OS↑, Synergy↑, BioAv↑,
5607- NaHCO3,    Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review
- Review, Var, NA
AntiCan↑, e-pH↑, TumMeta↓, TumCI↓, TumCG↓, CD8+↑, NK cell↑, Remission↑, Synergy↑, ChemoSen↑, ChemoSen↓,
5606- NaHCO3,    Effects of Alkalization Therapy on Chemotherapy Outcomes in Metastatic or Recurrent Pancreatic Cancer
- Trial, PC, NA
Dose↝, OS↑, Synergy↑,
5605- NaHCO3,    A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis
- Trial, HCC, NA
Synergy↑, Dose↝, other↓, OS↑, toxicity↓, AntiCan↓,
5602- NaHCO3,  immuno,    Immunotherapy Enhancement by Targeting Extracellular Tumor pH in Triple-Negative Breast Cancer Mouse Model
- in-vivo, BC, 4T1
Synergy↑, TumCG↓, OS↑, e-pH↑, IFN-γ↑, IL2↑, IL12↑, Dose↝, PD-L1↓,
1801- NarG,    A Narrative Review on Naringin and Naringenin as a Possible Bioenhancer in Various Drug-Delivery Formulations
- Review, Var, NA
AntiCan↓, CYP19↓, PI3K↓, Akt↓, TumAuto↑, Synergy↑, BioEnh↑,
5253- NCL,    Niclosamide: Beyond an antihelminthic drug
- Review, Var, NA
TumCP↓, Apoptosis↑, EMT↓, β-catenin/ZEB1↓, TumCG↓, toxicity↓, Wnt↓, LRP6↓, Synergy↑, DR5↑, mTORC1↓, pH↓, CSCs↓, IL6↓, JAK1↓, STAT3↓, ChemoSen↑, TumCG↓, tumCV↓, NOTCH↓, NF-kB↓, EGFR↓, ROS↑, RadioS↑, cFos↓, cJun↓, E2Fs↓, cMyc↓, Half-Life↓, BioAv↝,
5254- NCL,    The magic bullet: Niclosamide
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, RAS↓, STAT3↓, NOTCH↓, E2Fs↓, mTOR↓, Synergy↑, PD-1↓, PD-L1↓, BioAv↝, toxicity↓, BioAv↑, ETC↑, NADH:NAD↓, TCA↑, Warburg↓, Diff↑, AMPK↑, P53↑, PP2A↑, HIF-1↓, KRAS↓, Myc↓, RadioS↑, ChemoSen↑, Dose↝, Dose↑,
8430- OM,  T4O,    Exploring the Anticancer Potential of Origanum majorana Essential Oil Monoterpenes Alone and in Combination against Non-Small Cell Lung Cancer
- vitro+vivo, NSCLC, A549 - in-vitro, Lung, LNM35
tumCV↓, TumCG↓, survivin↓, Synergy↑, Dose↝,
2074- PB,  Chemo,    The effect of combined treatment with sodium phenylbutyrate and cisplatin, erlotinib, or gefitinib on resistant NSCLC cells
- in-vitro, Lung, A549 - in-vitro, Lung, Calu-6 - in-vitro, Lung, H1650
TumCG↓, Synergy↑, ChemoSen↑, HDAC↓,
2044- PB,  DCA,    Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate
- in-vivo, NA, NA
PDK1 / PDPK1↓, PDKs↓, Synergy↑, PDH↑,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, Synergy↑, hTERT/TERT↓, cycD1/CCND1↓, Synergy↑, Synergy↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1676- PBG,    Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
- Review, Var, NA
ROS↑, MMP↓, Bcl-2↓, Synergy↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,
4954- PEITC,    Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
- vitro+vivo, Ovarian, SKOV3
ROS↑, GSH↓, selectivity↑, mtDam↑, TumCD↑, OS↑, eff↑, *toxicity↓, H2O2↑, NO↑, eff↓, GPx↓, Dose↝, Synergy↑,
4959- PEITC,    Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment
- in-vitro, Ovarian, NA
CSCs↓, ALDH↓, CSCsMark↓, Synergy↑,
4926- PEITC,    PEITC inhibits the invasion and migration of colorectal cancer cells by blocking TGF-β-induced EMT
- in-vitro, CRC, SW48
TumCI↓, TumCMig↓, EMT↓, Smad1↓, AntiCan↑, Snail↓, Slug↓, Zeb1↓, ZEB2↓, TGF-β1↓, Synergy↑, E-cadherin↑, N-cadherin↓, Vim↓,
4929- PEITC,  PacT,    Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
ChemoSen↑, Apoptosis↑, TumCCA↑, Synergy↑, CDK1↓, Bcl-2↓, BAX↑, cl‑PARP↑, SAL↑,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
3595- PI,    Black pepper and health claims: a comprehensive treatise
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *Synergy↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,
1948- PL,  BNL,    Natural borneol serves as an adjuvant agent to promote the cellular uptake of piperlongumine for improving its antiglioma efficacy
- in-vitro, GBM, NA
selectivity↑, ROS↑, BioAv↓, BioAv↑, Apoptosis↑, TumCCA↑, Synergy↑,
1941- PL,    Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer
- in-vitro, HNSCC, NA
selectivity↑, Synergy↑, ROS↑, toxicity↑, GSH↓, GSSG↑, *GSSG∅, cl‑PARP↑, PUMA↑, GSTP1/GSTπ↓, ChemoSen↑,
2943- PL,    Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin
- in-vitro, CRC, HCT116 - in-vitro, Lung, A549 - in-vitro, BC, MCF7
TrxR1?, TumCD↑, ROS↑, GSH↓, Synergy↑,
2951- PL,  AF,    Synergistic Dual Targeting of Thioredoxin and Glutathione Systems Irrespective of p53 in Glioblastoma Stem Cells
- in-vitro, GBM, U87MG
GSH↓, Synergy↑, GSTP1/GSTπ↓,
3917- PS,    Phosphatidylserine, inflammation, and central nervous system diseases
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *neuroP↑, *cognitive↑, *Choline↑, *IL1β↓, *IL6↓, *TNF-α↓, *Ach↑, *Synergy↑, *Synergy↑, *BioEnh↑, other↑,
4965- PSO,  Cisplatin,    The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis
- vitro+vivo, GC, HGC27 - vitro+vivo, GC, MKN45
TumCP↓, TumCMig↓, TumCI↓, TumCG↓, *toxicity↓, Synergy↑, Ferroptosis↑, ACSL4↑, GPx4↓, ChemoSen↑, chemoP↑, AntiTum↑, Sepsis↓,
1994- PTL,    Parthenolide Inhibits Tumor Cell Growth and Metastasis in Melanoma A2058 Cells
- in-vitro, Melanoma, A2058 - in-vitro, Nor, L929
tumCV↓, selectivity?, ROS?, BAX↑, TumCCA?, MMP2↓, MMP9↓, TumCMig↓, Synergy↑,
4690- PTS,  immuno,    Pterostilbene: Mechanisms of its action as oncostatic agent in cell models and in vivo studies
- Review, Var, NA
eff↑, Half-Life↑, TumCG↓, TumMeta↓, angioG↓, CSCs↓, Apoptosis↑, Synergy↑, CD44↓, CD24↓,
3607- QC,    Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
- Review, AD, NA - Review, Park, NA
*neuroP↑, *NRF2↑, *PONs↑, *antiOx↑, *Inflam↓, *SIRT1↑, *Synergy↑, *ROS↓, *cognitive↑, *Synergy↑, *lipid-P↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑,
3380- QC,    Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
- Review, Var, NA - Review, Park, NA - Review, AD, NA
JAK↓, STAT↓, Inflam↓, NO↓, COX2/PTGS2↓, CRP↓, selectivity↑, *neuroP↑, STAT3↓, cycD1/CCND1↓, MMP2↓, STAT4↓, JAK2↓, TumCP↓, Diff↓, *Synergy↑, *IL6↓, *TNF-α↓, *IL1β↓, *Aβ↓,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2/PTGS2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *Synergy↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2/KDR/Flk1↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2/PTGS2↓, cFLIP↓, cycD1/CCND1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, Synergy↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
3376- QC,    Inhibiting CDK6 Activity by Quercetin Is an Attractive Strategy for Cancer Therapy
- in-vitro, BC, MCF7 - in-vitro, Lung, A549
CDK6↓, tumCV↓, Apoptosis↑, ROS↓, ChemoSen↑, *Synergy↑,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, Synergy↑, HIF-1↓,
97- QC,  HPT,    Effects of the flavonoid drug Quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo
- in-vitro, Pca, PC3
HSP72↑, TumCG↓, Synergy↑, ChemoSen↑, RadioS↑,
94- QC,  HPT,    Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, JCA-1
HSP70/HSPA5↓, TumCCA↑, TumCG↓, Synergy↑,
81- QC,  EGCG,    Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
- in-vivo, Pca, NA
COMT↓, MRP1/ABCC1↓, Ki-67↓, Bax:Bcl2↑, AR↓, Akt↓, p‑ERK↓, COMT↓, Synergy↑, chemoPv↑, BioAv↑,
5030- QC,    Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
- in-vivo, Nor, NA
*MitoP↑, *NRF2↑, Synergy↑, *eff↓, *GutMicro↑,
4827- QC,  CUR,    Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin
- Review, Var, NA
*AntiCan↑, *Inflam↓, *Bacteria↓, *AntiDiabetic↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *NRF2↑, *Trx↑, *IronCh↑, *MDA↑, cycD1/CCND1↓, PI3K↓, Casp3↑, BAX↑, ChemoSen↑, ROS↑, Synergy↑, MMP↓, Cyt‑c↑, Akt↓, ERK↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, Synergy↑, HK2↓, ROS↑, MMP↓,

Showing Research Papers: 301 to 350 of 416
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 416

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

APE1/APEX1↓, 1,   AURKB↓, 1,   CBR1↓, 1,   CD47↓, 1,   CLDN7↑, 1,   compV↓, 1,   ERCC3↑, 1,   H3K9↓, 3,   IRes↓, 1,   KAI1/CD82↑, 1,   miR-107↑, 1,   miR-124-3p↓, 1,   miR-224↓, 1,   miR-375↑, 1,   miR-422a↑, 1,   MMP16↓, 1,   MYCN↑, 1,   NA↑, 2,   OGFr↑, 1,   OLIG2↓, 1,   ORR↑, 1,   PFS↓, 1,   PFS↑, 1,   PLA2↓, 1,   PSEN1/PS1↓, 1,   PTN↓, 1,   RBC↑, 1,   SUV39H↓, 3,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   antiOx⇅, 1,   ATF3↑, 1,   Catalase↓, 3,   Catalase↑, 2,   compI↓, 2,   CYP1A1↑, 1,   Fenton↑, 5,   Ferroptosis↓, 1,   Ferroptosis↑, 15,   frataxin↑, 1,   GPx↓, 3,   GPx↑, 2,   GPx4↓, 5,   GPx4↑, 1,   GSH↓, 21,   GSH↑, 1,   GSH↝, 1,   GSR↑, 1,   GSSG↑, 1,   GSTP1/GSTπ↓, 2,   GSTs↓, 1,   GSTZ1↓, 1,   H2O2↑, 5,   HK1↓, 1,   HO-1↓, 3,   HO-1↑, 10,   hyperG↓, 1,   ICD↑, 2,   Iron↑, 5,   i-Iron↑, 2,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 10,   MDA↓, 1,   MDA↑, 4,   Mets↑, 1,   MFN2↑, 1,   NQO1↑, 3,   NRF2↓, 10,   NRF2↑, 13,   OXPHOS↓, 6,   OXPHOS↑, 4,   OXPHOS↝, 2,   PARK2↑, 1,   PrxI↓, 1,   PYCR1↓, 1,   ROS?, 2,   ROS↓, 18,   ROS↑, 175,   ROS⇅, 3,   i-ROS↑, 1,   mt-ROS↑, 3,   SIRT3↓, 1,   SIRT3↑, 2,   SOD↓, 4,   SOD↑, 3,   Trx↓, 3,   Trx1↓, 1,   Trx2↓, 1,   TrxR↓, 4,   TrxR1?, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 5,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   KLF5↓, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   AIF↑, 2,   ATP↓, 14,   ATP↑, 1,   mt-ATP↓, 1,   BCR-ABL↓, 1,   CDC2↓, 3,   CDC25↓, 1,   compIII↓, 1,   EGF↓, 2,   ETC↓, 1,   ETC↑, 1,   ETC↝, 1,   FGFR1↓, 1,   Insulin↓, 2,   MEK↓, 5,   mitResp↓, 1,   mitResp↑, 3,   MMP↓, 57,   MMP↑, 3,   Mortalin↓, 1,   MPT↑, 4,   mtDam↑, 10,   OCR↓, 2,   OCR↑, 2,   PGC-1α↑, 1,   PINK1↑, 1,   Raf↓, 2,   c-Raf↓, 1,   SDH↓, 1,   XIAP↓, 12,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 3,   ACLY↓, 4,   p‑ACLY↓, 1,   ACSL4↑, 2,   adiP↑, 1,   ALAT↓, 4,   ALAT↑, 1,   AMP↑, 1,   AMPK↑, 17,   ATG7↑, 2,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   citrate↓, 2,   cMyc↓, 23,   CPT1A↓, 1,   CYP3A4↓, 1,   ECAR↓, 1,   FASN↓, 4,   FASN↑, 1,   FGF21↓, 1,   glucoNG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 6,   GlucoseCon↑, 1,   GlutMet↓, 1,   glyC↓, 1,   Glycolysis↓, 33,   Glycolysis↑, 1,   Histones↝, 1,   HK2↓, 16,   HMG-CoA↓, 9,   KeyT↑, 1,   lactateProd↓, 11,   lactateProd↑, 1,   LDH↓, 10,   p‑LDH↓, 1,   LDHA↓, 6,   LDL↓, 3,   lipoGen↓, 2,   NADH:NAD↓, 1,   NADPH↓, 4,   NADPH↑, 2,   PDH↓, 1,   PDH↑, 5,   p‑PDH↑, 1,   PDHB↓, 1,   PDK1 / PDPK1↓, 8,   PDK3↑, 1,   PDKs↓, 10,   PFK↓, 2,   PFK2?, 1,   PFKFB2↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 11,   PKM2↑, 1,   POLD1↓, 1,   PPARα↓, 2,   PPARγ↓, 1,   PPARγ↑, 3,   p‑S6K↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 4,   SIRT2↓, 2,   SREBP2↓, 2,   STK11/LKB1↑, 1,   TCA↓, 2,   TCA↑, 1,   TS↓, 1,   Warburg↓, 10,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis?, 2,   Apoptosis↓, 4,   Apoptosis↑, 119,   ASK1↑, 1,   BAD↑, 4,   BAD↝, 1,   Bak↑, 4,   BAX↓, 3,   BAX↑, 59,   BAX↝, 2,   Bax:Bcl2↑, 16,   Bcl-2↓, 67,   Bcl-2↑, 2,   Bcl-2↝, 1,   Bcl-xL↓, 15,   Bcl-xL↑, 1,   BID↑, 1,   BIM↑, 6,   Casp↑, 18,   Casp1↑, 1,   Casp12?, 1,   Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 3,   Casp3↑, 77,   cl‑Casp3↑, 11,   cl‑Casp3⇅, 1,   proCasp3↑, 2,   pro‑Casp3↑, 1,   Casp7↑, 6,   cl‑Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 8,   cl‑Casp8↑, 2,   proCasp8↑, 2,   pro‑Casp8↑, 1,   Casp9↓, 1,   Casp9↑, 42,   cl‑Casp9↑, 6,   proCasp9↑, 2,   cFLIP↓, 2,   Chk2↓, 1,   CK2↓, 4,   Cupro↑, 1,   Cyt‑c↑, 35,   Diablo↑, 4,   DR4↑, 5,   DR5↑, 14,   FADD↑, 2,   Fas↑, 10,   FasL↑, 2,   Ferroptosis↓, 1,   Ferroptosis↑, 15,   GSDME-N↑, 1,   HEY1↓, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 10,   IAP1↓, 3,   IAP2/BIRC3↓, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 6,   iNOS↑, 2,   JNK↓, 3,   JNK↑, 9,   p‑JNK↓, 3,   p‑JNK↑, 1,   MAPK↓, 8,   MAPK↑, 5,   MAPK↝, 1,   p‑MAPK↓, 1,   Mcl-1↓, 16,   Mcl-1↑, 1,   MDM2↓, 3,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↑, 2,   Myc↓, 4,   Myc↑, 1,   Necroptosis↑, 3,   necrosis↑, 2,   NOXA↑, 1,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 7,   p38↓, 2,   p38↑, 5,   p‑p38↓, 1,   p‑p38↑, 2,   Paraptosis↑, 2,   Proteasome?, 1,   Proteasome↓, 3,   PUMA↑, 3,   Pyro↑, 3,   survivin↓, 24,   Telomerase↓, 6,   TRAIL↑, 1,   TRPV1↑, 1,   TumCD↓, 2,   TumCD↑, 18,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 67,   Akt↑, 11,   p‑Akt↓, 17,   Akt2↓, 1,   AMPKα↑, 1,   cSrc↓, 1,   EF-1α↓, 1,   FOXD3↑, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 7,   miR-25-5p↓, 1,   p70S6↓, 1,   SOX9?, 1,   SOX9↓, 1,   Sp1/3/4↓, 7,   TRPV2↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↝, 1,   cJun↓, 7,   cJun↑, 3,   EZH2↓, 3,   H3↑, 2,   ac‑H3↑, 3,   H3K4↓, 1,   H4↑, 1,   ac‑H4↑, 3,   HATs↓, 3,   HATs↑, 1,   miR-21↓, 2,   miR-27a-3p↓, 1,   other↓, 5,   other↑, 9,   other↝, 11,   PCAF↓, 1,   PhotoS↑, 3,   pRB↓, 1,   p‑pRB↓, 2,   sonoS↑, 2,   tumCV?, 1,   tumCV↓, 31,   tumCV↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 9,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 2,   p‑eIF2α↑, 2,   ER Stress↑, 34,   GRP78/BiP↓, 2,   GRP78/BiP↑, 9,   GRP78/BiP↝, 1,   GRP94↑, 1,   HSP27↓, 4,   HSP70/HSPA5↓, 6,   HSP70/HSPA5↑, 4,   HSP72↑, 1,   HSP90↓, 9,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 3,   PERK↑, 4,   UPR↑, 9,   XBP-1↓, 1,   XBP-1↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 2,   autoF↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 8,   p‑Beclin-1/ATG6↑, 1,   BNIP3↑, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 2,   LC3II↓, 1,   LC3II↑, 9,   LC3s↓, 1,   lysosome↓, 1,   MitoP↑, 1,   p62↓, 5,   p62↑, 6,   SESN2↑, 1,   TumAuto↑, 32,   TumAuto⇅, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   DNA-PK↑, 2,   DNAdam↑, 38,   DNArepair↓, 2,   DNArepair↑, 1,   DNMT1↓, 7,   DNMT3A↓, 2,   DNMT3B↓, 1,   DNMTs↓, 5,   m-FAM72A↓, 1,   GADD45A↑, 1,   MGMT↓, 1,   p16↑, 1,   P53↓, 2,   P53↑, 36,   p‑P53↓, 1,   p‑P53↑, 3,   PARP↑, 9,   p‑PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 35,   cl‑PARP↝, 1,   PARP1↑, 1,   cl‑PARP1↑, 1,   PCNA↓, 13,   SIRT6↓, 1,   TP53↓, 2,   TP53↑, 3,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 9,   CDK2↓, 20,   CDK4↓, 27,   CDK4↑, 3,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   CycB/CCNB1↓, 12,   cycD1/CCND1↓, 41,   CycD3↓, 3,   cycE/CCNE↓, 13,   cycE1↓, 1,   E2Fs↓, 2,   mitA↑, 1,   P21?, 2,   P21↓, 3,   P21↑, 21,   RB1↑, 1,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 4,   TumCCA↑, 87,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 5,   ALDH1A1↓, 1,   CD133↓, 3,   CD133↑, 1,   CD24↓, 1,   CD44↓, 7,   cFos↓, 7,   cMYB↓, 2,   CSCs↓, 35,   CSCsMark↓, 1,   CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   Diff↓, 3,   Diff↑, 6,   EMT↓, 47,   EMT↑, 2,   ERK↓, 13,   ERK↑, 5,   ERK↝, 1,   p‑ERK↓, 11,   FGF↓, 1,   FOXM1↓, 3,   FOXO↑, 1,   FOXO1↓, 2,   FOXO3↓, 1,   FOXO3↑, 7,   FOXO4↓, 1,   FOXO4↑, 1,   Gli↓, 1,   Gli1↓, 4,   GSK‐3β↓, 4,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   HDAC↓, 19,   HDAC1↓, 2,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC8↓, 1,   HH↓, 6,   HMGCR↓, 1,   HMGCR↑, 1,   HMGCR⇅, 1,   HMTs↓, 1,   IGF-1?, 1,   IGF-1↓, 6,   IGF-1R↓, 3,   IGF-1R↑, 1,   IGFBP1↑, 2,   IGFBP3↑, 1,   KLF4↓, 1,   Let-7↑, 2,   LRP6↓, 1,   p‑MAP2K1/MEK1↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   mTOR↓, 41,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 3,   mTORC1↓, 4,   p‑mTORC1↓, 1,   mTORC2↓, 1,   n-MYC↓, 2,   Nanog↓, 9,   Nestin↓, 3,   NOTCH↓, 6,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↑, 4,   NOTCH3↓, 3,   OCT4↓, 7,   p300↓, 1,   P70S6K↓, 3,   p‑P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 51,   PI3K↑, 4,   p‑PI3K↓, 3,   PTCH1↓, 2,   PTCH2↓, 1,   PTEN↑, 11,   RAS↓, 6,   SAL↑, 1,   Shh↓, 3,   SHP1↑, 2,   Smo↓, 1,   SOX2↓, 4,   Src↓, 1,   STAT↓, 2,   STAT3↓, 41,   STAT3↝, 1,   p‑STAT3↓, 9,   p‑STAT3↑, 4,   STAT4↓, 1,   STAT5↓, 1,   STAT6↓, 2,   TCF↓, 1,   TCF↑, 1,   TCF-4↓, 1,   TOP1↓, 5,   TOP2↓, 2,   TOP2↑, 1,   TRPM7↓, 1,   TumCG↓, 71,   TumCG↑, 2,   tyrosinase↓, 1,   Wnt↓, 22,   Wnt↑, 2,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 5,   annexin II↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 5,   AXL↓, 1,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 13,   CAFs/TAFs↓, 1,   cal2↑, 1,   CC(CDKs/cyclins)↓, 1,   CD11b↑, 2,   CDKN1C/p57↑, 1,   CLDN1↓, 3,   CLDN2↓, 1,   CLDN2↑, 1,   Cofilin↓, 1,   CXCL12↓, 2,   E-cadherin↓, 4,   E-cadherin↑, 25,   ER-α36↓, 2,   FAK↓, 5,   p‑FAK↓, 2,   fascin↓, 2,   Fibronectin↓, 5,   GLI2↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   ITGB4↓, 1,   Ki-67↓, 17,   Ki-67↑, 1,   KLF2↓, 1,   KRAS↓, 2,   L-sel↑, 1,   LAMs↓, 2,   MALAT1↓, 3,   MET↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-29b↓, 1,   miR-340↓, 1,   miR-384↑, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP13↓, 1,   MMP15↓, 1,   MMP2↓, 40,   MMP2↑, 1,   MMP3↓, 2,   MMP7↓, 6,   MMP9↓, 49,   MMP9↑, 2,   MMPs↓, 19,   MUC1↑, 1,   MUC4↓, 1,   N-cadherin↓, 16,   PAK1↓, 1,   PDGF↓, 2,   PKA↓, 1,   PKA↑, 1,   PKCδ↓, 5,   RECK↑, 1,   Rho↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   ROCK1↓, 3,   Slug↓, 9,   Smad1↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail?, 1,   Snail↓, 13,   SOX4↓, 2,   STAC2↓, 1,   TET1↑, 4,   TGF-β↓, 11,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 4,   Treg lymp↓, 2,   TRIB3↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI↓, 51,   TumCMig↓, 36,   TumCMig↑, 1,   TumCP?, 1,   TumCP↓, 69,   TumCP↑, 2,   TumMeta↓, 36,   TumMeta↑, 2,   Twist↓, 7,   uPA↓, 9,   uPAR↓, 1,   VEGFR1↓, 1,   Vim?, 1,   Vim↓, 19,   Zeb1↓, 10,   Zeb1↑, 1,   ZEB2↓, 2,   ZO-1↑, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 28,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 53,   angioG↑, 2,   ATF4↓, 1,   ATF4↑, 7,   ECM/TCF↓, 1,   EGFR↓, 19,   eNOS↓, 2,   eNOS↑, 1,   EPR↓, 1,   EPR↑, 1,   HIF-1↓, 4,   Hif1a↓, 34,   Hif1a↑, 1,   Hypoxia↓, 1,   miR-126↑, 1,   NO↓, 4,   NO↑, 2,   PDGFR-BB↓, 2,   p‑PDGFR-BB↓, 1,   VEGF↓, 58,   VEGFR2/KDR/Flk1↓, 7,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   BBB∅, 1,   CellMemb↑, 1,   GLUT1↓, 6,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↝, 1,   P-gp/ABCB1∅, 1,   SMCT1∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD4+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 45,   COX2/PTGS2↑, 3,   CRP↓, 2,   CXCR4↓, 9,   FOXP3↓, 1,   HCAR2↑, 1,   HMGB1↓, 3,   IFN-γ↓, 1,   IFN-γ↑, 3,   IKKα↓, 3,   IL1↓, 1,   IL10↓, 4,   IL10↑, 1,   IL12↓, 1,   IL12↑, 2,   IL1α↓, 1,   IL1β↓, 9,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 4,   IL4↓, 2,   IL4↑, 1,   IL6↓, 21,   IL8↓, 5,   Imm↑, 16,   Imm↝, 3,   INF-γ↑, 1,   Inflam↓, 19,   IκB↑, 1,   JAK↓, 3,   JAK1↓, 2,   JAK2↓, 7,   M2 MC↓, 3,   MCP1/CCL2↓, 4,   MIP2↓, 1,   MyD88↑, 1,   NF-kB↓, 65,   NF-kB↑, 4,   NF-kB↝, 1,   p‑NF-kB↓, 1,   NK cell↑, 9,   p65↓, 4,   ac‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 6,   PD-L1↑, 1,   PGE1↓, 1,   PGE2↓, 19,   PSA↓, 5,   PSA∅, 1,   T-Cell↑, 2,   T-Cell↝, 1,   Th1 response↑, 3,   Th2↑, 1,   TLR4↓, 2,   TLR4↑, 1,   TNF-α↓, 15,   TNF-α↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 2,   pH↑, 1,   e-pH↑, 4,   i-pH↓, 1,   TIM-3↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,   PP2A↑, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 10,   CDK6↓, 8,   CDK6↑, 4,   COMT↓, 2,   CYP19↓, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   GR↑, 1,   RANKL↓, 1,   SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 19,   BioAv↑, 33,   BioAv↝, 13,   BioEnh↑, 1,   chemoR↓, 1,   ChemoSen↓, 3,   ChemoSen↑, 137,   ChemoSen⇅, 2,   CYP1A2↓, 1,   CYP2C9↓, 1,   DDS↑, 1,   Dose?, 1,   Dose↓, 5,   Dose↑, 9,   Dose↝, 50,   Dose∅, 15,   eff↓, 32,   eff↑, 88,   eff↝, 5,   eff∅, 1,   Half-Life↓, 7,   Half-Life↑, 4,   Half-Life↝, 6,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 1,   P450↓, 1,   RadioS↑, 45,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 71,   Synergy↑, 434,   TET2↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 4,   ALAT↑, 1,   ALP↓, 2,   AR↓, 10,   ascitic↓, 1,   AST↓, 2,   AST↑, 1,   BG↓, 3,   BRCA1↓, 1,   CRP↓, 2,   E6↓, 2,   E7↓, 2,   EGFR↓, 19,   ERα/ESR1↓, 1,   EstroRS/ERS↑, 1,   EZH2↓, 3,   Ferritin↓, 2,   FOXM1↓, 3,   GutMicro↑, 6,   HER2/EBBR2↓, 7,   hTERT/TERT↓, 10,   IL6↓, 21,   Ki-67↓, 17,   Ki-67↑, 1,   KRAS↓, 2,   LDH↓, 10,   p‑LDH↓, 1,   Myc↓, 4,   Myc↑, 1,   NOS2↓, 1,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 5,   PSA∅, 1,   TG/TAG↓, 1,   TP53↓, 2,   TP53↑, 3,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 32,   AntiCan∅, 1,   antiNeop↑, 3,   AntiTum↓, 2,   AntiTum↑, 17,   cachexia↓, 1,   cardioP↑, 5,   CardioT↓, 1,   chemoP↑, 19,   chemoPv↑, 7,   ChemoSideEff↓, 11,   fatigue↓, 2,   hepatoP↓, 1,   hepatoP↑, 5,   memory↑, 1,   NDRG1↑, 1,   neuroP↑, 5,   NP/CIPN↓, 3,   OS↑, 30,   PDE4↓, 1,   Pin1↓, 2,   QoL↑, 7,   QoL∅, 1,   radioP↑, 7,   Remission↑, 3,   RenoP↑, 3,   Risk↓, 20,   Risk↑, 2,   Risk∅, 1,   toxicity↓, 20,   toxicity↑, 3,   toxicity↝, 9,   toxicity∅, 5,   TumVol↓, 17,   TumW↓, 8,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   CD8+↑, 7,   Sepsis↓, 2,  
Total Targets: 887

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 6,   compII↑, 1,   diuretic↑, 2,   NA↑, 1,   NeuroI↓, 1,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   Stress↓, 1,   Stroke↓, 3,   TRPA1↑, 1,   UFR↑, 1,   UR↓, 1,   β-HEX↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 5,   antiOx↑, 65,   Catalase↑, 26,   Copper↓, 1,   Fenton↓, 1,   Ferroptosis↓, 3,   GPx↑, 20,   GPx4↑, 1,   GSH↑, 24,   GSR↑, 3,   GSSG↓, 1,   GSSG∅, 1,   GSTA1↑, 1,   GSTs↑, 9,   H2O2↓, 1,   H2O2↑, 1,   H2O2∅, 1,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 1,   HO-1↑, 20,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↝, 1,   lipid-P↓, 23,   MDA↓, 19,   MDA↑, 1,   MPO↓, 4,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 38,   PARK2↑, 1,   Prx↑, 1,   RNS↓, 2,   ROS?, 1,   ROS↓, 73,   ROS↝, 1,   mt-ROS?, 1,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 35,   SOD2↑, 2,   TAC↑, 5,   TBARS↓, 1,   Trx↑, 1,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 2,   ATP↓, 1,   ATP↑, 7,   ATP↝, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   FIS1↓, 2,   Insulin↑, 1,   MMP↑, 5,   mtDam↓, 2,   PGC-1α↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   adiP↑, 1,   ALAT↓, 10,   AMPK↓, 1,   AMPK↑, 8,   p‑cMyc↑, 1,   CREB↑, 1,   CYP3A2↓, 1,   cytoP450↓, 1,   FASN↓, 1,   glucose↓, 5,   glucose↝, 1,   GlucoseCon↑, 2,   GLUT2↑, 1,   H2S↑, 1,   LDH↓, 3,   LDL↓, 6,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NAD↝, 1,   NADPH↓, 1,   NADPH↑, 1,   PONs↑, 1,   PPARγ↓, 2,   PPARγ↑, 2,   p‑PPARγ↓, 1,   SIRT1↑, 6,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 2,   BAX↑, 1,   Bax:Bcl2↓, 2,   Bcl-2↓, 2,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 7,   Casp3↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 2,   Casp9↑, 1,   Cyt‑c↓, 3,   Fas↓, 1,   FasL↓, 1,   Ferroptosis↓, 3,   GADD34↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 10,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 7,   MAPK↑, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 2,   AKT1↓, 1,   TRPV3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 2,   other↓, 3,   other↑, 14,   other↝, 8,   other∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   p‑eIF2α↓, 1,   ER Stress↓, 4,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   GADD45A↑, 1,   P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   Diff↝, 1,   ERK↓, 3,   ERK↑, 2,   GH↑, 1,   GSK‐3β↓, 6,   p‑GSK‐3β↑, 1,   HDAC↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,   mTOR↓, 3,   mTOR↑, 1,   neuroG↑, 1,   PI3K↓, 5,   PI3K↑, 2,   PTEN↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 1,   TumCG∅, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 3,   AntiAg↑, 8,   AP-1↓, 3,   APP↓, 1,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 3,   Cartilage↑, 2,   Ki-67↓, 1,   LRP1↑, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 3,   MUC1↑, 1,   PKCδ?, 1,   PKCδ↓, 2,   PKCδ↑, 2,   RAGE↓, 2,   serineP↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   VCAM-1↓, 4,   ZO-1↑, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 2,   ATF4↓, 2,   EGFR↓, 1,   eNOS↓, 1,   EPR↑, 1,   Hif1a↓, 1,   Hif1a↑, 1,   NO?, 1,   NO↓, 9,   NO↑, 1,   TXA2↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 2,   BBB↑, 12,   BBB↝, 1,   GastroP↑, 2,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 2,   OCLN↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 17,   COX2/PTGS2↑, 1,   CRP↓, 6,   ICAM-1↓, 3,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1?, 1,   IL1↓, 3,   IL10↓, 3,   IL10↑, 3,   IL12↓, 1,   IL17↓, 3,   IL18↓, 2,   IL1β↓, 20,   IL2↓, 2,   IL33↓, 1,   IL4↓, 2,   IL6?, 1,   IL6↓, 32,   IL8↓, 3,   Imm↓, 1,   Imm↑, 7,   Inflam↓, 86,   Inflam↑, 2,   LPS↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   MCP1/CCL2↝, 1,   MUC2↓, 1,   MyD88↓, 1,   NF-kB↓, 28,   PGE2↓, 8,   PSA↓, 2,   TLR2↓, 2,   TLR4↓, 2,   TLR4↑, 1,   TNF-α↓, 38,   TNF-α↑, 1,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   AChE↓, 8,   BChE↓, 2,   BDNF↓, 1,   BDNF↑, 5,   GABA↑, 2,   MAOA↓, 2,   NGF↑, 1,   tau↓, 6,   p‑tau↓, 6,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 16,   BACE/β-secretase↓, 7,   NLRP3↓, 8,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   DHT↓, 1,   Leptin↓, 1,   testos↓, 1,   testos↑, 1,   TSHR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 23,   BioAv↑, 45,   BioAv⇅, 2,   BioAv↝, 15,   BioEnh↑, 3,   ChemoSen↑, 1,   Dose↑, 4,   Dose↝, 25,   eff↓, 1,   eff↑, 15,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 9,   MRP1/ABCC1↓, 1,   P450↓, 2,   selectivity↑, 2,   Synergy↑, 73,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 10,   ALP↓, 2,   AST↓, 13,   BloodF↑, 2,   BMD↑, 3,   BMPs↑, 1,   BP↓, 7,   BP↝, 1,   Calcium↑, 1,   creat↓, 2,   CRP↓, 6,   EGFR↓, 1,   GutMicro↑, 14,   Hcy/homoC↝, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 32,   Ki-67↓, 1,   LDH↓, 3,   Mag↑, 1,   MUC19↓, 1,   PSA↓, 2,   RAGE↓, 2,   Urea↓, 1,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 4,   antiAll↑, 9,   AntiArt↑, 4,   AntiCan↑, 10,   AntiDiabetic↑, 13,   AntiP↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP↓, 1,   cardioP↑, 31,   CardioT↓, 1,   chemoP↑, 10,   chemoPv↑, 5,   ChemoSideEff↓, 1,   cognitive↑, 24,   cognitive↝, 1,   hepatoP↑, 24,   memory↑, 20,   Mood↑, 1,   motorD↑, 3,   neuroP↓, 1,   neuroP↑, 55,   Obesity↓, 8,   Pain↓, 4,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 10,   Risk↓, 4,   Sleep↑, 2,   Strength↑, 1,   toxicity↓, 28,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 6,   toxicity∅, 6,   Weight↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1,   AntiFungal↑, 3,   AntiViral↑, 5,   Bacteria↓, 15,   Diar↓, 2,   IRF3↓, 1,   Sepsis↓, 1,  
Total Targets: 383

Scientific Paper Hit Count for: Synergy, Synergy
23 Curcumin
15 Vitamin C (Ascorbic Acid)
14 Quercetin
13 Chrysin
12 Sulforaphane (mainly Broccoli)
12 Dichloroacetate
11 Metformin
11 Lycopene
10 EGCG (Epigallocatechin Gallate)
9 Chemotherapy
9 Resveratrol
8 Silver-NanoParticles
8 Artemisinin
8 Ashwagandha(Withaferin A)
8 Fisetin
7 Atorvastatin
7 Berberine
7 immunotherapy
6 Radiotherapy/Radiation
6 Hyperthermia
6 Magnetic Fields
6 Apigenin (mainly Parsley)
6 Vitamin K2
6 Silymarin (Milk Thistle) silibinin
6 Inositol
6 Bicarbonate(Sodium)
6 Thymoquinone
5 Melatonin
5 Dipyridamole
5 Carvacrol
5 diet FMD Fasting Mimicking Diet
5 Fenbendazole
5 Formononetin
5 Gambogic Acid
5 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
5 Rosmarinic acid
4 3-bromopyruvate
4 Auranofin
4 Alpha-Lipoic-Acid
4 Gemcitabine (Gemzar)
4 Propolis -bee glue
4 Capsaicin
4 salinomycin
4 diet Methionine-Restricted Diet
4 Dandelion Root
4 Disulfiram
4 Hydrogen Gas
4 Matrine
4 Phenethyl isothiocyanate
4 Piperlongumine
4 Urolithin
4 VitK3,menadione
3 1,8-Cineole
3 Photodynamic Therapy
3 Astaxanthin
3 beta-carotene(VitA)
3 borneol
3 Caffeic acid
3 Carnosic acid
3 chaetocin
3 chitosan
3 5-fluorouracil
3 Copper and Cu NanoParticles
3 Piperine
3 Emodin
3 Eugenol
3 Genistein (soy isoflavone)
3 Honokiol
3 Ivermectin
3 Juglone
3 Kaempferol
3 Luteolin
3 Terpinen-4-ol / Tea Tree Oil
3 Selenium NanoParticles
2 2-DeoxyGlucose
2 cetuximab
2 Vitamin B12
2 Folic Acid, Vit B9
2 chemodynamic therapy
2 Trichostatin A
2 Allicin (mainly Garlic)
2 Andrographis
2 isoquercitrin
2 Aspirin
2 Baicalein
2 Biochanin A
2 Betulinic acid
2 Lutein
2 Zeaxanthin
2 hydroxychloroquine
2 Thymol-Thymus vulgaris
2 Sorafenib (brand name Nexavar)
2 Chlorogenic acid
2 Citric Acid
2 Coenzyme Q10
2 Ellagic acid
2 Bortezomib
2 Docosahexaenoic Acid
2 Oxygen, Hyperbaric
2 Vitamin A, Retinoic Acid
2 erastin
2 Exercise
2 Ferulic acid
2 ferumoxytol
2 Fucoidan
2 Gallic acid
2 Cisplatin
2 Gamma-aminobutyric acid
2 doxorubicin
2 Ginkgetin
2 Gossypol/AT-101
2 HydroxyCitric Acid
2 Spermidine
2 Lecithin
2 Niclosamide (Niclocide)
2 Phenylbutyrate
2 Shikonin
2 Selenite (Sodium)
2 Vitamin D3
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 EMF
1 SonoDynamic Therapy UltraSound
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anti-oxidants
1 Acer okamotoanum
1 5-Aminolevulinic acid
1 almonertinib
1 D-limonene
1 Huperzine A/Huperzia serrata
1 Bufalin/Huachansu
1 Bifidobacterium
1 Boron
1 Boswellia (frankincense)
1 Butyrate
1 Cannabidiol
1 Centella asiatica / Gotu kola → asiaticoside
1 Beta‐Lapachone
1 Chlorophyllin
1 Rutin
1 Trastuzumab
1 Cinnamon
1 Hydroxycinnamic-acid
1 Selenium
1 Cucurbitacin
1 Dasatinib/Phyrago
1 Diclofenac
1 diet Ketogenic
1 Docetaxel
1 Ascorbyl Palmitate
1 Mistletoe/Viscum album Extracts
1 Echinacea
1 Electrical Pulses
1 Beta-Caryophyllene
1 temozolomide
1 Geldanamycin
1 Radicicol/monorden
1 Arsenic trioxide
1 olaparib/LYNPARZA
1 Galloflavin
1 verapamil
1 Garcinol
1 Ginkgo biloba
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginkgolide B
1 Gold NanoParticles
1 Calorie Restriction Mimetics
1 iodine
1 Inulin Prebiotic
1 isoorientin
1 itraconazole
1 Recombinant Methioninase
1 tumor necrosis factor-related apoptosis-inducing ligand
1 lambertianic acid
1 Lapatinib
1 low dose naltrexone
1 Licorice
1 Linalool
1 Vitamin E
1 Magnolol
1 methotrexate
1 Magnetic Field Rotating
1 Magnesium
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Naringin
1 Marjoram (Origanum majorana)
1 Paclitaxel/Taxol
1 Phosphatidylserine
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 Sulfasalazine
1 acetaminophen
1 acetazolamide
1 statins
1 triptolide
1 Turmerones
1 Vitexin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1849  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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