P53 Cancer Research Results

P53, P53-Guardian of the Genome: Click to Expand ⟱
Source: TCGA
Type: Proapototic
TP53 is the most commonly mutated gene in human cancer. TP53 is a gene that encodes for the p53 tumor suppressor protein ; TP73 (Chr.1p36.33) and TP63 (Chr.3q28) genes that encode transcription factors p73 and p63, respectively, are TP53 homologous structures.
p53 is a crucial tumor suppressor protein that plays a significant role in regulating the cell cycle, maintaining genomic stability, and preventing tumor formation. It is often referred to as the "guardian of the genome" due to its role in protecting cells from DNA damage and stress.
TP53 gene, which encodes the p53 protein, is one of the most frequently mutated genes in human cancers.
Overexpression of MDM2, an inhibitor of p53, can lead to decreased p53 activity even in the presence of wild-type p53.
In some cancers, particularly those with mutant p53, there may be an overexpression of the p53 protein.
Cancers with overexpression: Breast, lung, colorectal, overian, head and neck, Esophageal, bladder, pancreatic, and liver.
Scientific Papers found: Click to Expand⟱
8262- LE,    Phytochemical profiling, antimicrobial, cytotoxic and apoptotic effects of Glycyrrhiza glabra ethanolic extract
- in-vitro, Liver, HepG2
*Dose↝, *AntiBio↑, Dose↝, P53↑, BAX↑, Bcl-2↓, Apoptosis↑,
8276- LE,  Cisplatin,    Glycyrrhizin enhances the antitumor activity of cisplatin in non‑small cell lung cancer cells by influencing DNA damage and apoptosis
- in-vitro, NSCLC, NA
tumCV↓, ChemoSen↑, Apoptosis↑, TumCCA↑, Bcl-xL↑, cl‑Casp↑, γH2AX↑, P53↑,
8277- LE,    Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights
- Review, Var, NA
*antiOx↑, *AntiTum↑, HMGB1↓, COX2/PTGS2↓, PGE2↓, TumCP↓, TumCCA↑, Synergy↑, MMP↓, p‑P53↑, BAX↑, cl‑PARP↑, proCasp3↑, proCasp8↑, proCasp9↑, ROS↑, TumAuto↑, MMP9↓, TumMeta↓, PI3K↓, Akt↓, eff↑, *chemoP↑, *NRF2↑, *NF-kB↓,
8281- LE,    A Licorice Roots Extract Induces Apoptosis and Cell Cycle Arrest and Improves Metabolism via Regulating MiRNAs in Liver Cancer Cells
- in-vitro, Liver, NA
Apoptosis↑, TumCCA↑, Let-7↑, miR-34b-5p↑, miR-122-5p↑, miR-126↑, miR-195↑, miR-199↑, miR-206↑, miR-326-5p↑, Hif1a↓, PI3K↓, cMyc↓, AMPK↑, P53↑, Glycolysis↓, HK2↓, LDHA↓, PKM2↓, PPP↓, G6PD↓, GlutaM↓, GLS↓, miR-21↑, miR-221↑, miR-222↑,
8131- LF,    Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma
- in-vitro, OS, HSC2 - in-vitro, OS, HSC3 - in-vitro, OS, HSC4 - in-vitro, Nor, RT7
P53↑, Akt↓, SOCS-3↑, mTOR↓, JAK↓, STAT3↓, selectivity↑, TumCP↓, Iron↓, TumCCA↑,
8134- LF,    Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways
- in-vitro, CRC, HT-29
Iron↓, Apoptosis↑, selectivity↑, Casp8↑, P53↑, P21↑,
8140- LF,    Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
P53↑, AChE↑, Ach↓, VEGF↓, Akt↓,
8139- LF,    Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis
- vitro+vivo, Pca, NA
Ferroptosis↓, AR↝, Iron↝, Ferritin↑, P53↓, eff↝, other↝, AntiTum↓,
8187- LGE,    Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- in-vitro, BC, 4T1 - in-vitro, Ovarian, OVCAR-3 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Bcl-2↓, ER Stress↑, CHOP/DDIT3↑, GADD45A↑, EDEM↑, ATF4↑, HSP90↑, ATG5↑, eIF2α↑, ROS↑, P53↑, eff↓,
8184- LGE,    Cytotoxicity of citral against melanoma cells: The involvement of oxidative stress generation and cell growth protein reduction
- in-vitro, Melanoma, B16-BL6 - in-vitro, Nor, HaCaT
TumCP↓, ROS↑, DNAdam↑, P53↝, NO↓, NF-kB↓, ERK↓, Akt↓, selectivity↑,
8183- LGE,    Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
TumCG↓, selectivity↑, MMP↓, ROS↑, GSH↓, eff↓, p‑P53↑, BAX↑, Bcl-2↓, Bcl-xL↓, cl‑Casp3↑,
8333- LIN,    Linalool preferentially induces robust apoptosis of a variety of leukemia cells via upregulating p53 and cyclin-dependent kinase inhibitors
- in-vitro, AML, NA
TumCG↓, Apoptosis↑, selectivity↑, P53↑, CC(CDKs/cyclins)↑,
6480- LIN,    Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs
- in-vitro, lymphoma, U937 - in-vitro, Var, HeLa
TumCD↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, p16↑, CDKN2C/p18↑,
8376- LT,  Cisplatin,    Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization
- vitro+vivo, Var, NA
ChemoSen↑, JNK↑, P53↑,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8391- LT,    Mechanism of luteolin against non-small-cell lung cancer: a study based on network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments
- in-vitro, NSCLC, NA
other↝, TumCP↓, TumCMig↓, Apoptosis↑, p‑Akt↓, MDM2↓, Bcl-2↓, P53↑, BAX↑,
8406- LT,  Cisplatin,    Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase–mediated p53 phosphorylation and stabilization
- vitro+vivo, Liver, HepG2 - in-vitro, Laryn, HEp2
ChemoSen↑, Dose↝, P53↑,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
2915- LT,    Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
- in-vitro, Colon, HT29 - in-vitro, CRC, SNU-407 - in-vitro, Nor, FHC
DNMTs↓, TET1↑, NRF2↑, HDAC↓, tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, ROS↓, GSS↑, Catalase↑, HO-1↑, DNMT1↓, DNMT3A↓, TET1↑, TET3↑, TET2↓, P53↑, P21↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑, *antiAll↑, *Mucositis↓, *TregCell↑, *Beclin-1/ATG6↓, *PI3K↑, *Akt↑, *mTOR↑,
8346- Lut,    Lutein inhibits tumor progression through the ATR/Chk1/p53 signaling pathway in non-small cell lung cancer
- vitro+vivo, NSCLC, A549
TumCP↓, TumCCA↑, Apoptosis↑, P53↑, DNAdam↑, ATR↑, CHK1↑, TumCG↓, OS↑,
8347- Lut,    Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
- in-vitro, BC, NA
TumCG↓, TumCCA↑, selectivity↑, ROS↑, eff↓, P53↑, HSP60/HSPD1↑, cycF↑, CDC25↑, CDK6↑, ANAPC2↑, AURKB↑, GADD45A↑, BAX↑, Casp3↑, CASP4↑, Casp8↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, DR6↑, ChemoSen↑,
8343- Lut,    Association of Lutein with Cancer: A Systematic Review of the Lutein Effects on Cellular Processes Involved in Cancer Progression
- Review, Var, NA
*antiOx↑, *Inflam↓, Risk↓, AntiCan∅, Apoptosis↑, ROS↓, NRF2↓, Akt↓, ERK↓, NF-kB↓, Bcl-2↓, BAX↑, Casp3↑, DNAdam↑, ROS↓, P53↑, PCNA↓, cycD1/CCND1↓, TumCP↓, Hif1a↓, NOTCH↓, miR-590-3p↑, TumCMig↓, TumCI↓, TumMeta↓, TumCA↓, *BioAv↓,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27/CDKN1B↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2/PTGS2↓, lipid-P↓, GSH↑, NRF2↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
1715- Lyco,    Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence
- Review, Var, NA
antiOx↑, ROS↑, ChemoSen↑, selectivity↑, eff↓, Casp3↑, Casp7↑, Casp9↑, P53↑, BAX↑, DNAdam↑, mtDam↑, Synergy↑,
8407- Lyco,    Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines
- in-vitro, Pca, LNCaP
CholSyn↓, HMGCR↓, RAS↓, NF-kB↓, ROS↓, p‑Jun↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, p‑Akt↓, P21↑, p27/CDKN1B↑, P53↑, Bax:Bcl2↑,
4778- Lyco,    Lycopene exerts cytotoxic effects by mitochondrial reactive oxygen species–induced apoptosis in glioblastoma multiforme
- in-vitro, GBM, GBM8401
BBB↑, Apoptosis↑, TumCP↑, P53↑, CycB/CCNB1↓, cycD1/CCND1↓, TumCCA↓, mt-ROS↑, TumCG↓,
4780- Lyco,    Potential inhibitory effect of lycopene on prostate cancer
- Review, Pca, NA
TumCP↓, TumCCA↑, Apoptosis↑, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *Ca+2↝, *antiOx↑, *AntiCan↑, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *TNF-α↓, NF-kB↓, DNAdam↓, PSA↓, P53↓, cycD1/CCND1↓, NRF2↓, Akt2↓, PPARγ↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, Synergy↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, ChemoSen↑,
4797- Lyco,    A mechanistic updated overview on lycopene as potential anticancer agent
- Review, Var, NA
AntiCan↑, antiOx↓, Apoptosis↑, TumCP↓, TumCCA↑, Risk↓, ROS↓, SOD↑, Catalase↑, GSTs↑, ARE↑, NRF2↑, cycD1/CCND1↓, cycE/CCNE↑, CDK2↑, p27/CDKN1B↑, BAX↑, Bcl-2↓, P53↑, ChemoSen↑,
4795- Lyco,    Updates on the Anticancer Profile of Lycopene and its Probable Mechanism against Breast and Gynecological Cancer
- Review, BC, NA
TumCG↓, TumCCA↑, Apoptosis↑, P53↝, BAX↝, cycD1/CCND1↓, ERK↓, Akt↓, STAT3↓, NRF2↝, NF-kB↓, ITGB1↓, ITGA5↓, FAK↓, MMP9↓, EMT↓,
8519- MAG,    Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway
- vitro+vivo, Gall, NA
TumCG?, TumCCA↑, mt-Apoptosis↑, P53↑, P21↑, cycD1/CCND1↓, CDC25↓, CDK2↓, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, cl‑PARP↑,
8497- MAG,    Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway
- in-vitro, BC, MCF7
TumCP↓, Apoptosis↑, *TumCCA↑, *ROS↑, *MMP↓, *Cyt‑c↑, *AIF↑, *BAX↑, *P21↑, *P53↑, *Bcl-2↓, *CycB/CCNB1↓, *CDK1↓,
4518- MAG,  Cisplatin,    Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells
- in-vitro, GC, MKN45
ChemoSen↑, tumCV↓, BAX↑, Bcl-2↓, P21↑, P53↑, MMP9↓,
4514- MAG,    Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
- Review, Var, NA
AntiCan↑, TumCP↓, TumCCA↑, TumMeta↓, angioG↓, NF-kB↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, BioAv↓, *antiOx↑, *Inflam↓, *AntiAg↑, ChemoSen↑, cycD1/CCND1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p27/CDKN1B↑, P21↑, P53↑, PTEN↓, XIAP↓, Mcl-1↓, Casp3↑, Casp9↑, MMP9↑,
4531- MAG,    Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway
- in-vitro, CRC, HCT116
Apoptosis↑, DNAdam↑, Casp3↑, cl‑PARP↑, p‑AMPK↑, Bcl-2↓, P53↑, BAX↑, Cyt‑c↑, TumCMig↓, TumCI↓,
8568- Matr,    Matrine induces apoptosis via targeting CCR7 and enhances the effect of anticancer drugs in non-small cell lung cancer in vitro
- in-vitro, NSCLC, A549
tumCV↓, P53↑, BAX↑, Casp3↑, Bcl-2↓, CCR7↓, ChemoSen↑,
8541- Matr,    Matrine induces ferroptosis and suppresses colorectal cancer through targeting the STAT3/SLC7A11 pathway
- in-vivo, CRC, NA
TumCP↓, necrosis↑, Ferroptosis↑, TumCD↑, lipid-P↑, MDA↑, GSH↓, xCT/SLC7A11↓, P53↑, p‑STAT3↓,
8544- Matr,    Matrine in Liver Diseases: Mechanistic Insights and Therapeutic Potential
- Review, BC, NA
*hepatoP↑, *Inflam↓, *ROS↓, *ER Stress↓, *lipid-P↓, TumCP↓, TumCI↓, TumCMig↓, TumAuto↑, Apoptosis↑, *AST↓, *ALAT↓, *SOD↑, *MDA↓, *TNF-α↓, *IL6↓, *NRF2↑, *HO-1?, *NF-kB↓, *Inflam↓, AFP?, PCNA↓, cMyc↓, Bcl-2↓, BAX↑, EMT↓, MDM2↓, P53↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, NOTCH↑, ChemoSen↑, eff↑, survivin↓, XIAP↓, Synergy↑,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8545- Matr,    Matrine enhances RLS3-induced ferroptosis at non-toxic doses in acute myeloid leukemia cells with MLL rearrangement
- in-vitro, AML, MV411 - in-vitro, ALL, MOLM-13
Ferroptosis↑, Synergy↑, i-Iron↑, ROS↑, MMP↓, GSH↓, xCT/SLC7A11↓, GPx4↓, P53↑,
8636- MBZ,    Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer
- in-vivo, Ovarian, SKOV3
TumCG?, P53↑, P21↑, Synergy↑, Dose↝,
8650- MBZ,    Autophagy Is a Potential Target for Enhancing the Anti-Angiogenic Effect of Mebendazole in Endothelial Cells
- in-vitro, Var, NA
TumCP↓, TumCCA↑, Apoptosis↑, DNAdam↑, P53↑, Casp3↑, TumAuto↑, Synergy↑, eff↑,
994- MET,    Tumor metabolism destruction via metformin-based glycolysis inhibition and glucose oxidase-mediated glucose deprivation for enhanced cancer therapy
- in-vitro, Var, NA
Glycolysis↓, HK2↓, ATP↓, AMPK↑, P53↑, Warburg↓, Apoptosis↑,
1066- MET,    Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma
- in-vitro, SCC, NA
PDH↑, Hif1a↓, TumCMig↓, Casp3↑, P53∅,
2241- MF,    Pulsed electromagnetic therapy in cancer treatment: Progress and outlook
- Review, Var, NA
other↝, p‑ERK↝, P53↝, Cyt‑c↝, OXPHOS↑, Apoptosis↑, ROS↑,
8483- MF,    Magnetic Fields in Cancer Therapy: Mechanistic Insights, Signaling Pathways, and Evidence from Clinical and In Vitro Studies
- Review, Var, NA
Apoptosis↑, TumCP↓, Ferroptosis↑, TumCMig↓, EMT↓, ROS↝, ChemoSen↑, RadioS↑, Telomerase↓, selectivity↑, ROS↑, DNAdam↑, Casp↑, Ca+2↑, MMP↓, lysoMP↑, lipid-P↑, NA↑, other↑, ChemoSen↑, P53↑,
8486- MF,    Silent forces, hidden currents: the influence of static magnetic field stimulation on tumor biophysics
- Review, Var, NA
Ca+2↑, TumCG↓, MMP↓, CellMemb↑, SOX2↓, Nanog↓, cMyc↓, CD44↓, CD133↓, P53↑, ROS↑, DNAdam↑, CDK1↓, CycB/CCNB1↓, TumCCA↑, TumCP↓, pH↓, TumCP↓, Telomerase↓, ChemoSen↑, TRPV1↝, Bax:Bcl2↑, Casp3↑, Akt↓, mTOR↓, mitA↑, ROS↓, P-gp/ABCB1↓, MDR1↓, RadioS↑, Apoptosis↑, GSH↓, lipid-P↑, Iron↑, Iron↓, Fenton↑,

Showing Research Papers: 301 to 350 of 502
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 502

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 5,   antiOx↑, 14,   antiOx⇅, 1,   ARE↑, 1,   Catalase↓, 10,   Catalase↑, 8,   Copper↑, 1,   ENOX2↓, 1,   Fenton↑, 2,   frataxin↑, 1,   GPx↓, 2,   GPx↑, 5,   GPx4↓, 8,   GSH↓, 45,   GSH↑, 12,   GSH/GSSG↓, 1,   GSR↑, 3,   GSS↑, 1,   GSSG↑, 1,   GSTs↓, 2,   GSTs↑, 2,   GSTs↝, 1,   H2O2↑, 7,   HO-1↓, 7,   HO-1↑, 17,   HO-1⇅, 1,   HO-1↝, 1,   HO-2↓, 1,   Iron↓, 3,   Iron↑, 4,   Iron↝, 1,   i-Iron↑, 1,   Keap1↓, 1,   lipid-P↓, 8,   lipid-P↑, 15,   MDA↓, 2,   MDA↑, 10,   MPO↓, 1,   NADH↓, 2,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 3,   NRF2↓, 20,   NRF2↑, 29,   NRF2↝, 2,   PAO↑, 1,   Prx↓, 1,   PYCR1↓, 1,   RNS↑, 1,   ROS?, 1,   ROS↓, 27,   ROS↑, 262,   ROS⇅, 8,   ROS↝, 3,   ROS∅, 1,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 5,   SOD↓, 13,   SOD↑, 13,   SOD1↓, 1,   SOD1↑, 2,   SOD2↓, 2,   SOD2↑, 2,   TAC↓, 2,   TBARS↓, 1,   TBARS↑, 1,   Thiols↓, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 4,   TrxR1↓, 1,   xCT/SLC7A11↓, 6,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR↓, 1,   CDC16↓, 1,   CDC2↓, 7,   CDC2↑, 1,   CDC25↓, 14,   CDC25↑, 1,   CDC25↝, 1,   p‑CDC25↑, 1,   compI↓, 2,   compIII↓, 1,   compV↓, 1,   EGF↓, 5,   ETC↓, 4,   ETC↑, 1,   HSP60/HSPD1↑, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 4,   MKK7↓, 1,   mtDam↑, 22,   OCR↓, 5,   OXPHOS↓, 2,   OXPHOS↑, 4,   PDH↑, 2,   PHB↓, 1,   SDH↑, 1,   SIRT3↓, 2,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   5LO↓, 4,   ACC↑, 3,   ACSL4↑, 1,   ALAT↓, 4,   AMPK↓, 2,   AMPK↑, 28,   p‑AMPK↑, 2,   ATP↓, 14,   ATP↑, 1,   CAIX/CA9↓, 3,   CAIX/CA9↑, 1,   CholSyn↓, 1,   ECAR↓, 2,   ECAR↝, 1,   FAO↓, 1,   FAO↑, 1,   FASN↓, 10,   G6PD↓, 2,   GAPDH↓, 1,   GLO-I↓, 1,   GLS↓, 2,   GlucoseCon↓, 6,   GlutaM↓, 1,   GlutMet↓, 1,   Glycolysis↓, 27,   GSK‐3β↓, 9,   GSK‐3β↑, 6,   p‑GSK‐3β↓, 6,   H2S↑, 1,   Histones↑, 2,   HK1↓, 1,   HK2↓, 14,   HMG-CoA↓, 1,   IDH1↑, 1,   lactateProd↓, 6,   lactateProd↑, 1,   LDHA↓, 7,   LDL↓, 2,   MCT4↓, 1,   NADH:NAD↓, 1,   NADPH↓, 1,   NADPH↑, 1,   O-Glc↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 6,   PDKs↓, 1,   PFK↓, 1,   PFK1↓, 1,   PFKP↓, 1,   PKM2↓, 14,   PPP↓, 1,   p‑S6↓, 1,   SCD1↓, 1,   SIRT1↓, 7,   SIRT1↑, 10,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   SSAT↑, 1,   TCA↓, 1,   TCA↑, 1,   TS↓, 1,   Warburg↓, 6,  

Cell Death(tgid=5) ⓘ

AIF↑, 13,   APAF1↑, 11,   Apoptosis?, 1,   Apoptosis↓, 9,   Apoptosis↑, 250,   Apoptosis↝, 1,   mt-Apoptosis↑, 4,   BAD↓, 3,   BAD↑, 11,   Bak↓, 1,   Bak↑, 13,   BAX↓, 6,   BAX↑, 194,   BAX⇅, 1,   BAX↝, 2,   BAX∅, 1,   Bax:Bcl2↑, 31,   Bcl-2↓, 192,   Bcl-2↑, 4,   Bcl-2↝, 1,   Bcl-2∅, 1,   Bcl-xL↓, 48,   Bcl-xL↑, 2,   Bcl-xL↝, 1,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 10,   p‑BID↓, 1,   BIM↓, 1,   BIM↑, 8,   BNIP3↑, 2,   BNIP3↝, 1,   BOK↑, 1,   Casp↓, 2,   Casp↑, 40,   Casp↝, 1,   cl‑Casp↑, 2,   Casp1↑, 1,   Casp10↓, 1,   Casp10↑, 2,   Casp12↑, 2,   Casp12↝, 1,   Casp2↑, 1,   Casp3↓, 5,   Casp3↑, 180,   Casp3↝, 1,   cl‑Casp3↑, 37,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   proCasp3↑, 1,   CASP4↑, 1,   Casp6↑, 1,   Casp7↑, 22,   cl‑Casp7↑, 5,   Casp8↓, 1,   Casp8↑, 45,   cl‑Casp8↑, 5,   proCasp8↓, 1,   proCasp8↑, 1,   Casp9↑, 116,   p‑Casp9↑, 1,   cl‑Casp9↑, 11,   proCasp9↓, 3,   proCasp9↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 3,   Cyt‑c↑, 95,   Cyt‑c↝, 3,   mt-Cyt‑c↓, 1,   Diablo↑, 9,   DIDO1/DIO-1↑, 1,   DR5↓, 1,   DR5↑, 25,   Endon↑, 1,   FADD↑, 7,   Fap1↓, 1,   Fas↓, 2,   Fas↑, 26,   FasL↑, 10,   Ferroptosis↓, 1,   Ferroptosis↑, 13,   GRP58↓, 1,   GSDME-N↑, 1,   HEY1↓, 1,   IAP1↓, 12,   IAP2/BIRC3↓, 4,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   ICD↑, 2,   iNOS↓, 21,   iNOS↑, 2,   JWA↑, 1,   Mcl-1↓, 22,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 21,   MDM2↑, 3,   p‑MDM2↓, 1,   MLKL↑, 1,   p‑MLKL↓, 1,   MOMP↑, 2,   NAIP↓, 1,   Necroptosis↑, 3,   necrosis↑, 5,   NOXA↑, 6,   p38↓, 5,   p38↑, 22,   p‑p38↓, 3,   p‑p38↑, 3,   PUMA↑, 12,   Pyro↑, 2,   RIP1↑, 2,   RIP3↑, 3,   p‑RIP3↑, 1,   survivin↓, 61,   TNFR 1↑, 1,   TRAIL↑, 7,   TRAIL⇅, 1,   TRAILR↑, 3,   TumCD↓, 2,   TumCD↑, 23,   TUNEL↑, 1,   XIAP↓, 29,   XIAP↑, 1,   YAP/TEAD↓, 4,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 129,   Akt↑, 5,   Akt↝, 1,   p‑Akt↓, 35,   p‑Akt↑, 1,   AKT1↓, 2,   Akt2↓, 2,   AMPKα↑, 2,   CaMKII ↓, 1,   CDC7↓, 1,   CK2↓, 4,   cMET↓, 3,   cSrc↓, 1,   DDIT4↑, 1,   EF-1α↓, 1,   EGFR↓, 40,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 4,   ERK↓, 49,   ERK↑, 7,   ERK↝, 1,   p‑ERK↓, 11,   p‑ERK↑, 3,   p‑ERK⇅, 1,   p‑ERK↝, 1,   e-ERK↑, 1,   FGFR1↓, 4,   FGFR2↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↓, 2,   HRAS↓, 2,   IGF-1R↓, 3,   IGFR↓, 1,   IKKα↓, 7,   IKKα↑, 1,   p‑IKKα↓, 2,   IR↓, 1,   IκB↓, 1,   IκB↑, 1,   p‑IκB↓, 1,   JAK↓, 7,   JAK1↓, 2,   p‑JAK1↓, 1,   JAK2↓, 8,   p‑JAK2↓, 3,   p‑JAK3↓, 1,   JNK↓, 6,   JNK↑, 26,   JNK↝, 1,   p‑JNK↓, 3,   MAP2K1/MEK1↓, 2,   p‑MAP2K1/MEK1↓, 1,   MAPK↓, 39,   MAPK↑, 16,   MAPK↝, 3,   p‑MAPK↓, 1,   MEK↓, 3,   p‑MEK↓, 1,   MKK4↓, 1,   mTOR↓, 66,   mTOR↑, 3,   mTOR↝, 2,   p‑mTOR↓, 9,   mTORC2↓, 1,   p‑p42↓, 1,   p70S6↓, 1,   p70S6↑, 1,   P70S6K↓, 2,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PAK↓, 1,   PDGFR-BB↓, 1,   PDGFRA↓, 1,   PI3K↓, 92,   PI3K↑, 4,   PI3K↝, 2,   p‑PI3K↓, 4,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 1,   PIAS-3↑, 1,   PKA↓, 1,   PKCδ↓, 6,   PP2A↑, 1,   PTEN↓, 2,   PTEN↑, 25,   PTEN↝, 1,   Raf↓, 4,   e-Raf↓, 1,   c-Raf↓, 1,   RAS↓, 12,   RTK-RAS↓, 1,   p‑S6K↓, 1,   Sp1/3/4↓, 7,   Src↓, 2,   Src↑, 1,   STAT↓, 4,   STAT3↓, 62,   STAT3↑, 1,   p‑STAT3↓, 12,   i-STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 4,   STAT6↓, 1,   STK11/LKB1↑, 1,   TSC2↑, 3,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 3,   ATF4↓, 1,   ATF4↑, 11,   CBP↓, 1,   CBP↑, 1,   ChrMod↑, 2,   cJun↓, 6,   cJun↑, 4,   p‑cJun↑, 1,   cMyc↓, 43,   cMyc↑, 1,   p‑cMyc↑, 1,   DNMT1↓, 8,   DNMT3A↓, 2,   DNMT3B↓, 1,   DNMTs↓, 6,   EZH2↓, 1,   FOXM1↓, 2,   FOXO↑, 5,   FOXO1↓, 2,   FOXO1↑, 2,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   H3↓, 1,   H3↑, 2,   ac‑H3↑, 2,   H4↑, 1,   ac‑H4↑, 3,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 16,   HDAC1↓, 8,   HDAC10↓, 1,   HDAC10↑, 1,   HDAC2↓, 4,   HDAC3↓, 4,   HDAC4↓, 2,   HDAC8↓, 1,   miR-107↑, 1,   miR-122-5p↑, 1,   miR-125b↓, 1,   miR-126↑, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 1,   miR-155↓, 2,   miR-195↑, 1,   miR-199↑, 1,   miR-203↓, 1,   miR-206↑, 1,   miR-21↓, 3,   miR-21↑, 2,   miR-210↓, 1,   miR-210↑, 1,   miR-218↑, 1,   miR-221↑, 1,   miR-222↑, 1,   miR-224↓, 1,   miR-326-5p↑, 1,   miR-339-5p↝, 1,   miR-340↓, 1,   miR-34a↓, 1,   miR-34a↑, 7,   miR-34b-5p↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   miR-590-3p↑, 1,   Myc↓, 8,   MYCN↓, 1,   NDRG1↑, 1,   OCT4↓, 9,   other↓, 5,   other↑, 5,   other↝, 10,   PAX2↓, 1,   PhotoS↑, 1,   PRMT6↓, 1,   SOX2↓, 7,   SOX4↓, 2,   TCF-4↓, 1,   TET3↑, 1,   TFE3↑, 1,   tumCV?, 1,   tumCV↓, 60,  

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑ATF6↑, 1,   CHOP/DDIT3↑, 26,   cl‑CHOP/DDIT3↑, 1,   EDEM↑, 1,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 3,   ER Stress↑, 31,   GRP78/BiP↑, 10,   HSF1↓, 1,   HSP27↓, 5,   HSP27↝, 1,   HSP70/HSPA5↓, 5,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 10,   HSP90↑, 1,   HSPs↓, 2,   HSPs↑, 1,   IRE1↑, 4,   NPL4↓, 1,   NQO2↑, 1,   PDI↑, 1,   PERK↑, 3,   Proteasome↓, 1,   SERPINH1/HSP47↓, 1,   UPR↑, 3,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2,   ATG5↓, 1,   ATG5↑, 7,   ATG7↑, 5,   Beclin-1/ATG6↓, 5,   Beclin-1/ATG6↑, 20,   p‑Beclin-1/ATG6↑, 1,   CTSB↓, 1,   CTSD↓, 1,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3A↑, 1,   LC3B↑, 1,   LC3B-II↑, 2,   LC3I↓, 2,   LC3I↑, 1,   LC3II↓, 2,   LC3II↑, 16,   LC3s↑, 1,   lysoMP↑, 1,   p62↓, 7,   p62↑, 6,   SESN2↑, 3,   TumAuto↓, 1,   TumAuto↑, 48,   TumAuto↝, 2,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 9,   p‑ATM↑, 2,   ATR↑, 4,   BRCA1↓, 2,   BRCA1↑, 4,   p‑BRCA1↑, 1,   BRCA2↓, 1,   BRCA2↑, 1,   CUL4B↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 4,   DNAdam↑, 73,   DNArepair↓, 2,   DNArepair↑, 1,   ERCC3↑, 1,   hTERT/TERT↓, 11,   MDMX↓, 1,   MGMT↓, 2,   MSH2↑, 1,   p16↑, 5,   P53?, 3,   P53↓, 24,   P53↑, 422,   P53⇅, 1,   P53↝, 10,   P53∅, 2,   p‑P53↓, 2,   p‑P53↑, 19,   ac‑P53↑, 1,   i-P53↓, 1,   p53 Wildtype∅, 1,   PARP↓, 6,   PARP↑, 22,   p‑PARP↑, 3,   cl‑PARP↓, 1,   cl‑PARP↑, 66,   PARP1↑, 2,   cl‑PARP1↑, 3,   PCNA↓, 36,   SIRT6↓, 1,   SIRT6↑, 1,   Telomerase↓, 14,   TOP1?, 1,   TOP1↓, 2,   TOP2↓, 3,   TRF2↓, 1,   UHRF1↓, 1,   XRCC1↓, 1,   γH2AX↓, 1,   γH2AX↑, 13,   p‑γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   CC(CDKs/cyclins)↓, 1,   CC(CDKs/cyclins)↑, 1,   CDK1↓, 20,   CDK1↑, 4,   CDK1↝, 1,   CDK2↓, 45,   CDK2↑, 2,   CDK4↓, 52,   CDK4↑, 2,   p‑CDK4↓, 1,   CDK4/6↓, 2,   CDK6↓, 23,   CDK6↑, 2,   CDK8↓, 1,   CDKN2C/p18↑, 1,   CHK1↓, 4,   CHK1↑, 4,   CHK1↝, 1,   p‑CHK1↑, 2,   Chk2↓, 4,   Chk2↑, 3,   Cyc↓, 4,   Cyc↝, 1,   cycA1/CCNA1↓, 10,   cycA1/CCNA1↑, 3,   CycB/CCNB1↓, 38,   CycB/CCNB1↑, 2,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 94,   cycD1/CCND1↑, 1,   cycD1/CCND1↝, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 3,   cycE/CCNE↓, 28,   cycE/CCNE↑, 1,   cycE1↓, 1,   cycF↓, 1,   cycF↑, 1,   E2Fs↓, 6,   E2Fs↑, 1,   GADD45A↓, 1,   GADD45A↑, 3,   Ki-67↓, 27,   mitA↓, 1,   mitA↑, 3,   P21?, 2,   P21↓, 9,   P21↑, 133,   P21↝, 1,   p27/CDKN1B↓, 4,   p27/CDKN1B↑, 39,   pRB↑, 2,   p‑pRB↓, 3,   RB1↓, 1,   RB1↑, 4,   p‑RB1↓, 5,   TumCCA↓, 6,   TumCCA↑, 235,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 3,   Axin2↑, 1,   BMPs↑, 1,   CD133↓, 6,   CD133↑, 1,   CD24↓, 2,   cFos↓, 6,   CSCs?, 1,   CSCs↓, 32,   Diff↓, 1,   Diff↑, 2,   EIF4E↓, 1,   EP300↑, 1,   EP4/PTGER4↑, 1,   FGF↓, 4,   Gli1↓, 2,   HH↓, 1,   HMGCR↓, 2,   IGF-1↓, 10,   p‑IGF-1↓, 1,   IGFBP3↑, 3,   IGFBP7↑, 1,   p‑Jun↓, 1,   Ki-67↓, 27,   Let-7↑, 1,   mTORC1↓, 6,   Nanog↓, 9,   Nestin↓, 1,   NF2↑, 1,   NICD↓, 1,   NOTCH↓, 12,   NOTCH↑, 1,   NOTCH1↓, 12,   NOTCH1↝, 1,   NOTCH3↓, 2,   p300↓, 1,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 3,   Smo↓, 2,   STAT1↓, 1,   p‑STAT1↓, 1,   TAZ↓, 1,   TumCG?, 3,   TumCG↓, 74,   TumCG↑, 3,   TumCP?, 1,   TumCP↓, 146,   TumCP↑, 2,   TumCP⇅, 1,   tyrosinase↓, 1,   URGCP/URG4↓, 1,   Wnt?, 1,   Wnt↓, 31,   Wnt↝, 1,   Wnt/(β-catenin)↓, 6,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 10,   AP-1↝, 2,   APC↑, 1,   ATPase↓, 2,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 26,   Ca+2↝, 2,   i-Ca+2?, 1,   CAFs/TAFs↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 2,   Cdc42↓, 1,   COL1↓, 1,   COL3A1↓, 1,   CTNNB1↓, 1,   DLC1↑, 1,   E-cadherin↓, 6,   E-cadherin↑, 30,   EMT↓, 58,   EMT↑, 2,   EMT↝, 1,   EpCAM↓, 2,   FAK↓, 16,   p‑FAK↓, 4,   Fibronectin↓, 2,   GLI2↓, 2,   hnRNPA1↓, 1,   IQGAP3↓, 1,   ITGA5↓, 2,   ITGB1↓, 3,   ITGB3↓, 1,   ITGB4↓, 1,   ITGB6↓, 1,   KAI1/CD82↑, 1,   KRAS↓, 3,   LAMs↓, 2,   LEF1↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP1↓, 4,   MMP13↓, 4,   MMP16↓, 1,   MMP2↓, 61,   MMP2↝, 1,   MMP3↓, 6,   MMP7↓, 6,   MMP9↓, 81,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 32,   MTA1↓, 1,   MUC4↓, 1,   N-cadherin↓, 25,   p‑p44↓, 1,   PAK1↓, 1,   PAK1↑, 1,   pax↓, 1,   p‑pax↓, 1,   PDGF↓, 8,   proline↓, 1,   Rac1↓, 3,   RECK↑, 1,   Rho↓, 4,   ROCK1↓, 4,   Sharpin↓, 1,   Slug↓, 6,   SMAD3↓, 1,   SMAD4↑, 1,   Snail↓, 17,   TET1↓, 1,   TET1↑, 2,   TGF-β↓, 13,   THBS1↑, 1,   TIMP1↓, 1,   TIMP1↑, 9,   TIMP2↓, 2,   TIMP2↑, 9,   TIMP3↑, 1,   TPM4↓, 1,   TRIB3↑, 2,   TSC1↑, 1,   TSP-1↑, 4,   TumCA↓, 1,   TumCI↓, 55,   TumCI↑, 2,   TumCMig↓, 68,   TumCMig↑, 1,   TumMeta↓, 66,   TumMeta↑, 6,   Twist↓, 16,   uPA↓, 17,   uPAR↓, 1,   Vim↓, 31,   Zeb1↓, 8,   ZEB2↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 36,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 68,   angioG↑, 3,   CCN1/CYR61↓, 1,   CD31/PECAM-1↓, 6,   CD31/PECAM-1↑, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 7,   Hif1a↓, 56,   Hif1a↑, 2,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 8,   NO↑, 3,   VCAM-1↓, 2,   VEGF↓, 85,   VEGF↝, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 16,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   BBB∅, 1,   CellMemb↓, 1,   CellMemb↑, 2,   CLDN2↓, 1,   CTR1↑, 2,   EPR↑, 3,   GLUT1↓, 6,   GLUT1↑, 1,   GLUT3↓, 1,   GLUT3↑, 1,   GLUT4↓, 2,   KCNH2/hERG↓, 1,   MMP↓, 122,   MMP↑, 1,   MMP↝, 1,   MPT↑, 2,   NHE1↓, 2,   TRPV1↑, 4,   TRPV1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 3,   CD44↓, 9,   CD8+↑, 4,   cDC2↓, 2,   p‑cDC2↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 83,   COX2/PTGS2↝, 1,   CXCL1↓, 1,   CXCL12↓, 1,   CXCR2↓, 2,   CXCR3↓, 1,   CXCR4↓, 10,   DCells↑, 1,   DR4↑, 8,   DR6↑, 1,   FOXP3↓, 1,   HCAR1↓, 1,   HMGB1↓, 4,   ICAM-1↓, 1,   IFN-γ↓, 5,   IFN-γ↑, 2,   IL1↓, 8,   IL1↑, 1,   IL10↓, 6,   IL12↓, 4,   IL17↓, 1,   IL18↓, 1,   IL1α↓, 1,   IL1β↓, 17,   IL1β↑, 2,   IL2↓, 5,   IL2↑, 3,   IL4↓, 3,   IL4↑, 1,   IL5↓, 1,   IL6↓, 37,   IL6↝, 1,   IL8↓, 8,   Imm↑, 8,   Inflam↓, 30,   Inflam↝, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 3,   MDSCs↓, 1,   MyD88↑, 1,   NAF1↓, 1,   NF-kB↓, 148,   NF-kB↑, 9,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 4,   NLRP3↓, 4,   p50↓, 1,   p65↓, 9,   p65↑, 1,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-1↓, 2,   PD-1↝, 1,   PD-L1↓, 6,   PGE1↓, 1,   PGE2↓, 14,   PSA↓, 10,   PSA↝, 1,   RAGE↓, 2,   Resistin↓, 1,   SOCS-3↑, 2,   SOCS1↑, 1,   T-Cell↑, 1,   TCF↝, 1,   Th1 response↑, 1,   TLR4↓, 4,   TLR4↑, 1,   TNF-α↓, 34,   TNF-α↑, 7,   TNF-α↝, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   Treg lymp↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH↓, 1,   pH↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   Ach↓, 1,   AChE↑, 1,   PTN↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↑, 1,   AR↓, 12,   AR↑, 1,   AR↝, 2,   ER-α36↓, 3,   ER(estro)↓, 2,   ER(estro)↑, 1,   ERα/ESR1↓, 1,   Estro↝, 1,   EstroRS/ERS↓, 1,   FGF21↓, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARα↝, 1,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 7,   RANKL↓, 1,   SRC3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 33,   BioAv↑, 24,   BioAv↝, 8,   chemoR↓, 1,   ChemoSen↓, 2,   ChemoSen↑, 127,   ChemoSen↝, 1,   CompStab?, 1,   CompStab↓, 2,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↓, 4,   CYP1A1↑, 3,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP1B1↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 3,   Dose?, 3,   Dose↓, 1,   Dose↑, 6,   Dose⇅, 1,   Dose↝, 41,   Dose∅, 14,   eff?, 1,   eff↓, 37,   eff↑, 54,   eff↝, 10,   eff∅, 3,   GSTA1↑, 1,   Half-Life↓, 5,   Half-Life↝, 6,   MDR1↓, 5,   MRP1/ABCC1↓, 3,   P-gp/ABCB1↓, 17,   P-gp/ABCB1∅, 1,   P450↓, 4,   P450↝, 1,   RadioS↑, 39,   RadioS↝, 1,   selectivity?, 2,   selectivity↓, 2,   selectivity↑, 84,   Synergy↑, 65,   TET2↓, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 1,   ALAT↓, 4,   ALP↓, 1,   AR↓, 12,   AR↑, 1,   AR↝, 2,   AST↓, 4,   BG↓, 1,   BMD↑, 1,   BRCA1↓, 2,   BRCA1↑, 4,   p‑BRCA1↑, 1,   CEA↓, 1,   creat↓, 1,   CRP↓, 3,   E6↓, 7,   E7↓, 6,   EGFR↓, 40,   EGFR↑, 1,   EGFR↝, 1,   p‑EGFR↓, 4,   ERα/ESR1↓, 1,   EstroRS/ERS↓, 1,   EZH2↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   FOXM1↓, 2,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 11,   IL6↓, 37,   IL6↝, 1,   KRAS↓, 3,   LDH↓, 6,   LDH↑, 2,   i-LDH↓, 1,   Maspin↑, 1,   Myc↓, 8,   PD-L1↓, 6,   PSA↓, 10,   PSA↝, 1,   RAGE↓, 2,   TG/TAG↓, 1,   TRIB3↑, 2,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 36,   AntiCan∅, 1,   antiCG↓, 1,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 16,   Appetite↑, 1,   BowelM↑, 2,   breath↑, 1,   cachexia↓, 1,   cardioP↑, 6,   chemoP↑, 22,   chemoPv↑, 18,   ChemoSideEff↓, 6,   fatigue↓, 1,   hepatoP↑, 10,   motorD↑, 1,   Mucositis↓, 1,   neuroP↓, 1,   neuroP↑, 3,   NP/CIPN↓, 1,   OS?, 1,   OS↑, 16,   OS⇅, 1,   OS∅, 1,   Pain↓, 2,   QoL↑, 5,   radioP↑, 7,   RenoP↑, 6,   Risk↓, 13,   Sleep↑, 2,   Strength↑, 2,   TGFβR1↑, 1,   toxicity?, 1,   toxicity↓, 8,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 2,   TumVol↓, 23,   TumVol↑, 1,   TumW↓, 8,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 8,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↝, 1,  
Total Targets: 1117

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 2,   antiOx↑, 58,   ARE↑, 1,   Bil↓, 1,   Catalase↑, 32,   GPx↑, 27,   GPx1↑, 2,   GPx4↑, 1,   GSH↑, 26,   GSR↑, 5,   GSSG↓, 1,   GSTs↑, 11,   H2O2↓, 3,   HDL↑, 2,   HO-1?, 1,   HO-1↓, 2,   HO-1↑, 14,   Keap1↓, 2,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 30,   MDA↓, 19,   MDA↑, 1,   MPO↓, 3,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 33,   Prx↑, 1,   RNS↓, 3,   ROS↓, 69,   ROS↑, 4,   ROS∅, 2,   mt-ROS?, 1,   SOD↓, 1,   SOD↑, 37,   SOD1↑, 4,   SOD2↑, 5,   TAC↑, 4,   TBARS↓, 3,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   Insulin↑, 1,   MFN2↑, 1,   PGC-1α↝, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↝, 1,   ALAT↓, 11,   AMPK↓, 1,   AMPK↑, 7,   ATP↓, 1,   ATP↑, 4,   FASN↓, 1,   glucose↓, 5,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 2,   Glycolysis↑, 1,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   H2S↑, 1,   HK2↑, 1,   HMG-CoA↓, 1,   LDL↓, 2,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↑, 2,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   AIF↑, 1,   APAF1↓, 1,   Apoptosis↓, 3,   Apoptosis↑, 1,   ASK1↓, 1,   BAX↓, 4,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bax:Bcl2↝, 1,   Bcl-2↓, 2,   Bcl-2↑, 4,   Casp↓, 1,   Casp3?, 1,   Casp3↓, 10,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 7,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 4,   Cyt‑c↑, 1,   Cyt‑c∅, 1,   Fas↓, 1,   Fas↑, 2,   Ferroptosis↓, 1,   GSDMD↓, 1,   iNOS↓, 13,   p38↓, 2,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 3,   Akt2↓, 1,   ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 2,   IκB?, 1,   JAK↓, 2,   JNK↓, 4,   JNK↑, 1,   p‑JNK↓, 1,   MAPK↓, 6,   MAPK↑, 1,   mTOR↓, 1,   mTOR↑, 1,   PDGFR-BB↓, 1,   PI3K↓, 2,   PI3K↑, 2,   PKCδ↓, 1,   STAT3↓, 2,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF2↑, 1,   ATF4↓, 1,   p‑cMyc↑, 1,   FOXO3↑, 1,   HDAC2↓, 1,   other↓, 2,   other↑, 2,   other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   ER Stress↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 1,   LC3II↓, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   p16↓, 1,   P53↓, 12,   P53↑, 7,   P53↝, 1,   cl‑PARP↑, 2,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↑, 1,   E2Fs↑, 1,   GADD34↓, 1,   P21↓, 4,   P21↑, 4,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HH↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   AP-1↓, 3,   Ca+2↓, 2,   Ca+2↝, 1,   MLC2/MYL9↝, 1,   MMP13↓, 1,   MMP2↓, 1,   PAI-1/SERPINE1↓, 1,   TregCell↑, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   eNOS↑, 1,   Hif1a↓, 1,   NO↓, 8,   NO↑, 2,   VCAM-1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 8,   GastroP↑, 3,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 3,   H+/K+-ATPase↓, 1,   MMP↓, 3,   MMP↑, 4,   MMP∅, 1,   OCLN↝, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 21,   COX2/PTGS2↑, 1,   DR4↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 11,   IL4↓, 1,   IL5↓, 1,   IL6↓, 16,   IL6↑, 1,   IL8↓, 4,   Imm↓, 1,   Imm↑, 2,   Inflam↓, 59,   Inflam↑, 1,   pol-M2 MC↑, 1,   NeuroI↓, 1,   NF-kB?, 1,   NF-kB↓, 29,   p‑NF-kB↓, 1,   NLRP3↓, 1,   PGE2↓, 6,   PSA∅, 1,   RAGE↓, 1,   SOCS-3↓, 1,   TLR4↓, 3,   TNF-α↓, 26,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 2,   AChE↓, 14,   BChE↓, 3,   BDNF↓, 1,   BDNF↑, 2,   EndoR↑, 1,   GABA↑, 2,   MAOA↓, 1,   monoA↑, 1,   NGF↑, 1,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 1,   Aβ↓, 8,   BACE/β-secretase↓, 4,   tau↓, 2,   p‑tau↓, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   Estro↓, 1,   GPER↑, 1,   GR↑, 1,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 2,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 25,   BioAv↑, 24,   BioAv↝, 8,   BioAv∅, 1,   BioEnh↑, 1,   CompStab↑, 1,   Dose↝, 8,   Dose∅, 1,   eff↑, 7,   GSTA1↓, 1,   GSTA1↑, 1,   Half-Life↝, 5,   Half-Life∅, 2,   P450↓, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 11,   ALP↓, 4,   AST↓, 10,   Bil↓, 1,   BMD↑, 2,   BP↓, 3,   BUN↓, 1,   CEA↓, 1,   creat↓, 3,   CRP↓, 3,   hs-CRP↓, 1,   IL6↓, 16,   IL6↑, 1,   IRes↝, 1,   LDH↓, 6,   NOS2↓, 2,   PSA∅, 1,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll↑, 11,   AntiArt↑, 4,   AntiCan↑, 12,   antiD↓, 1,   AntiDiabetic↑, 15,   antiPs↑, 1,   AntiTum↑, 3,   Bone Healing↑, 1,   cardioP?, 1,   cardioP↑, 24,   chemoP↑, 6,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 8,   diuretic↑, 2,   hepatoP↓, 1,   hepatoP↑, 20,   Learn↑, 1,   memory↑, 8,   motorD↑, 2,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 40,   Obesity↓, 7,   OS↑, 1,   Pain↓, 3,   radioP↑, 3,   RenoP↑, 5,   Risk↓, 1,   Stroke↓, 5,   toxicity↓, 21,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 2,   Wound Healing↑, 5,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 10,   AntiFungal↑, 5,   AntiP↑, 2,   AntiViral↑, 9,   Bacteria↓, 16,   Bacteria↑, 1,   Diar↓, 1,   GutMicro↑, 8,   Inf↓, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 347

Scientific Paper Hit Count for: P53, P53-Guardian of the Genome
31 Silver-NanoParticles
20 Thymoquinone
18 Curcumin
18 Quercetin
16 Apigenin (mainly Parsley)
14 Fisetin
11 Magnetic Fields
11 Resveratrol
10 EGCG (Epigallocatechin Gallate)
9 Cisplatin
9 Propolis -bee glue
9 Capsaicin
9 Emodin
9 Lycopene
9 Phenethyl isothiocyanate
8 Luteolin
8 Shikonin
7 Silymarin (Milk Thistle) silibinin
7 Allicin (mainly Garlic)
7 Ashwagandha(Withaferin A)
7 Baicalein
7 Berberine
7 Kaempferol
7 Urolithin
6 Alpha-Lipoic-Acid
6 Radiotherapy/Radiation
6 Eugenol
6 Ferulic acid
6 Gambogic Acid
6 Melatonin
5 Chlorogenic acid
5 Ursolic acid
5 Ellagic acid
5 Licorice
5 Magnolol
5 Matrine
5 Sulforaphane (mainly Broccoli)
4 Bromelain
4 Chrysin
4 Selenium NanoParticles
4 Dandelion Root
4 Fenbendazole
4 Gallic acid
4 Lactoferrin/Talactoferrin
4 Nimbolide
4 Marjoram (Origanum majorana)
4 salinomycin
3 Metformin
3 Boron
3 NTP, Non-Thermal Plasma,Cold Atmospheric Plasma
3 D-limonene
3 Eurycomanone
3 Formononetin
3 Flaxseed/Linseed
3 Hibiscus sabdariffa
3 HydroxyTyrosol
3 Ivermectin
3 Juglone
3 Lemongrass Extract/Citral
3 Lutein
3 Magnetic Field Rotating
3 Aflavin-3,3′-digallate
2 Gemcitabine (Gemzar)
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Anethole/trans-Anethole
2 Isovitexin
2 Artemisinin
2 Astaxanthin
2 Berbamine
2 Betulinic acid
2 Brucea javanica
2 brusatol
2 α-Bisabolol / Chamomile oil
2 Carnosic acid
2 Caffeic acid
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Carvacrol
2 Celastrol
2 Crocetin
2 Cucurbitacin
2 Docetaxel
2 Dichloroacetate
2 Genistein (soy isoflavone)
2 Garcinol
2 Geraniol
2 Graviola
2 Honokiol
2 Indole-3-carbinol
2 doxorubicin
2 lambertianic acid
2 Licochalcone A
2 Linalool
2 mebendazole
2 Moringa oleifera
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Oleuropein
2 Piperine
2 Piperlongumine
2 Parthenolide
2 Pterostilbene
2 Selenite (Sodium)
2 Vitamin C (Ascorbic Acid)
2 VitK3,menadione
2 Vitexin
1 1,8-Cineole
1 Astragalus
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Camptothecin
1 tamoxifen
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 Aloe anthraquinones
1 epirubicin
1 Biochanin A
1 Beta-Caryophyllene
1 borneol
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Mung Bean Sprouts
1 Centella asiatica / Gotu kola → asiaticoside
1 Cinnamon
1 Carvone
1 Copper and Cu NanoParticles
1 Cynaropicrin
1 Date Fruit Extract
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Vitamin A, Retinoic Acid
1 Disulfiram
1 Ginkgo biloba-EGb 761
1 Tetrahydroxystilbene glucoside
1 Evodiamine
1 Exercise
1 SDG/lignans
1 Flaxseed Oil
1 olaparib/LYNPARZA
1 Paclitaxel/Taxol
1 carboplatin
1 Ginkgo biloba
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Hyperoside
1 isoorientin
1 Morin
1 Naringin
1 Niclosamide (Niclocide)
1 Neem
1 Oxygen, Hyperbaric
1 Phenylbutyrate
1 Propyl gallate
1 Plumbagin
1 Psoralidin
1 Rosmarinic acid
1 Rutin
1 buckwheat sprouts
1 Selenium
1 irinotecan
1 Oxaliplatin
1 Vitamin K2
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:236  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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